LOCUS       NZ_CP013019.1          17848 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  NZ_CP013019.1 Clostridium pasteurianum strain M150B chromosome,
            complete genome.
ACCESSION   NZ_CP013019
VERSION     NZ_CP013019.1
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 6.1.1
            Run date     :: 2024-03-14 15:30:35
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 2670329
            Orig. end    :: 2688177
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     CDS             complement(1..345)
                     /locus_tag="ctg1_2428"
                     /transl_table=11
                     /translation="MKKSKKIIAVLALLAILVPYTNAKATTDMVTSAGHSFNNDWEASV
                     TSSRYKYIYGYNTSWINEDYVHAIHYDYQHDAAVSNGGGGSGRDSAGPNSWAKIEITHK
                     SSAVNYGIIY"
     protocluster    1..17848
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[2678527:2679097](+)"
                     /cutoff="20000"
                     /detection_rule="(TIGR04223 or AgrB)"
                     /neighbourhood="10000"
                     /product="cyclic-lactone-autoinducer"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      8199..8768
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(TIGR04223 or AgrB)"
                     /neighbourhood="10000"
                     /product="cyclic-lactone-autoinducer"
                     /protocluster_number="1"
     cand_cluster    1..17848
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(TIGR04223 or AgrB)"
                     /kind="single"
                     /product="cyclic-lactone-autoinducer"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..17848
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="cyclic-lactone-autoinducer"
                     /region_number="7"
                     /rules="(TIGR04223 or AgrB)"
                     /tool="antismash"
     CDS             complement(627..1340)
                     /locus_tag="ctg1_2429"
                     /transl_table=11
                     /translation="VYQLFLKRGKAVVKQNYKKKIIYCNNTLFITIALFLVVILTVIFS
                     RRIIPYLLMSVNNKNIGVIHKISGFEIQALLEDTKVKSIILVKNDKDAENMAKKYEKLL
                     FGSNFQDYKVNILQRNKDFWRLELRAKNPSEKTYYTGGEYFISPSGELLGFQMLDFNTK
                     SSAALNNESVREEASKAAKEILQSLGYEDDYTLQLREHDIVITRLSVRYQPMYLSFGMY
                     ENKLYLLNMKGNWTD"
     CDS             complement(1288..2730)
                     /gene_functions="regulatory (smcogs) SMCOG1003:sensor
                     histidine kinase (Score: 176.6; E-value: 1.8e-53)"
                     /gene_kind="regulatory"
                     /locus_tag="ctg1_2430"
                     /transl_table=11
                     /translation="MRFWQKIFLSGYIVLFLSFNVIGILWLSRDYSDMVKRENSVALLA
                     HQSFQQSLYTSLVYWKNQLADSPDIYKVYQSDIILKLTHTGDNSRQVIVTNSNNEIIFS
                     NTSDTIKNNIENTMNKLDKDISYGMYKLDKDRVIIAGNSFKVGDDSFNLYTINNITEEY
                     NYQNKKINDFIEFGSIICILAAGILGIISYLLTKPLRKLETITKHISEGDYSRRVPLVG
                     NDEIYHLTEQINLMAETIDNREKKLKSIAEQRQRFVENFTHELKTPLTSIIAYADLMRT
                     VKQEPYEMDEGLNYISSEGKRLSSMAHKLMTMFHLKSGDLELKTTPLDIIFEQVHDILK
                     LRLKEKNIELKIHCDDISLNIERDLFKTLLINLLDNSIKASTYGDEIYLAGKEQDDKII
                     IEIIDKGFGIPEKELSYIMEPFYMVDKSRTRKHNGAGLGLTLCNEIVVLHHAVMNIKSE
                     ENKGTCVSIIFKKGKSGGETEL"
     PFAM_domain     complement(1318..1638)
                     /aSDomain="HATPase_c"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF02518.28"
                     /description="Histidine kinase-, DNA gyrase B-, and
                     HSP90-like ATPase"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_2430_0150"
                     /evalue="2.00E-20"
                     /label="ctg1_2430"
                     /locus_tag="ctg1_2430"
                     /protein_end="471"
                     /protein_start="364"
                     /score="73.4"
                     /tool="antismash"
                     /translation="LFKTLLINLLDNSIKASTYGDEIYLAGKEQDDKIIIEIIDKGFGI
                     PEKELSYIMEPFYMVDKSRTRKHNGAGLGLTLCNEIVVLHHAVMNIKSEENKGTCVSII
                     FKK"
     PFAM_domain     complement(1792..1971)
                     /aSDomain="HisKA"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00512.27"
                     /description="His Kinase A (phospho-acceptor) domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_2430_0149"
                     /evalue="1.60E-08"
                     /label="ctg1_2430"
                     /locus_tag="ctg1_2430"
                     /protein_end="313"
                     /protein_start="253"
                     /score="34.5"
                     /tool="antismash"
                     /translation="RQRFVENFTHELKTPLTSIIAYADLMRTVKQEPYEMDEGLNYISS
                     EGKRLSSMAHKLMTM"
     PFAM_domain     complement(2011..2160)
                     /aSDomain="HAMP"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00672.27"
                     /description="HAMP domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_2430_0148"
                     /evalue="1.40E-10"
                     /label="ctg1_2430"
                     /locus_tag="ctg1_2430"
                     /protein_end="240"
                     /protein_start="190"
                     /score="41.5"
                     /tool="antismash"
                     /translation="ISYLLTKPLRKLETITKHISEGDYSRRVPLVGNDEIYHLTEQINL
                     MAETI"
     CDS             complement(2734..3384)
                     /gene_functions="regulatory (smcogs) SMCOG1008:response
                     regulator (Score: 192.4; E-value: 1.3e-58)"
                     /gene_kind="regulatory"
                     /locus_tag="ctg1_2431"
                     /transl_table=11
                     /translation="MNNILVVEDEIPISNVICKYLKVAGYDTETAYNGQEALHKIETDK
                     FDLVLLDVMIPYLNGFDLIKILKPKNISVIFLTAKDELTDKLQGFRLGADDYITKPFEY
                     QELLARIRAVLNRNNKLTNKIVYGDVEINLDSHEVIKNGKQIELLPKEYELLILFIKNR
                     HIALTREVLMQKVWGYDFMGETRTIDAHVQRIRKKLGWKNEIKTIFKTGYRLE"
     PFAM_domain     complement(2740..2958)
                     /aSDomain="Trans_reg_C"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00486.30"
                     /description="Transcriptional regulatory protein, C
                     terminal"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_2431_0152"
                     /evalue="9.40E-21"
                     /label="ctg1_2431"
                     /locus_tag="ctg1_2431"
                     /protein_end="215"
                     /protein_start="142"
                     /score="73.8"
                     /tool="antismash"
                     /translation="GKQIELLPKEYELLILFIKNRHIALTREVLMQKVWGYDFMGETRT
                     IDAHVQRIRKKLGWKNEIKTIFKTGYRL"
     PFAM_domain     complement(3049..3375)
                     /aSDomain="Response_reg"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00072.26"
                     /description="Response regulator receiver domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_2431_0151"
                     /evalue="2.40E-26"
                     /label="ctg1_2431"
                     /locus_tag="ctg1_2431"
                     /protein_end="112"
                     /protein_start="3"
                     /score="92.2"
                     /tool="antismash"
                     /translation="ILVVEDEIPISNVICKYLKVAGYDTETAYNGQEALHKIETDKFDL
                     VLLDVMIPYLNGFDLIKILKPKNISVIFLTAKDELTDKLQGFRLGADDYITKPFEYQEL
                     LARIR"
     CDS             complement(3650..4294)
                     /gene_functions="transport (smcogs) SMCOG1000:ABC
                     transporter ATP-binding protein (Score: 159.1; E-value:
                     2.5e-48)"
                     /gene_kind="transport"
                     /locus_tag="ctg1_2432"
                     /transl_table=11
                     /translation="MNNLAVCVNDVCKAFKENQVLKNVSINFEKNKIHGLIGRNGSGKT
                     MLLKCICGFVPITSGEIIVNDKRIGKDTDVPKDVGIIIETPGFLPNYNGYKNLKFLASI
                     NNIIDKKDIKSVIKRVGLDPESKKWVGKYSLGMRQRLGMAQAIMENPSILLLDEPLNGI
                     DKHGVKDMRELLIKLRDEGKTIILASHSAEDIEMLCDTVSEMDSGVLTVLR"
     PFAM_domain     complement(3812..4234)
                     /aSDomain="ABC_tran"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00005.29"
                     /description="ABC transporter"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_2432_0153"
                     /evalue="1.50E-27"
                     /label="ctg1_2432"
                     /locus_tag="ctg1_2432"
                     /protein_end="161"
                     /protein_start="20"
                     /score="96.8"
                     /tool="antismash"
                     /translation="LKNVSINFEKNKIHGLIGRNGSGKTMLLKCICGFVPITSGEIIVN
                     DKRIGKDTDVPKDVGIIIETPGFLPNYNGYKNLKFLASINNIIDKKDIKSVIKRVGLDP
                     ESKKWVGKYSLGMRQRLGMAQAIMENPSILLLDEPLN"
     CDS             complement(4333..5187)
                     /locus_tag="ctg1_2433"
                     /transl_table=11
                     /translation="MANLQKTFFISINNIRKWASNPRIYILAALLFLMLWNYVNPILSF
                     SKIVNYRVAPWLFPYISNWYFTQMLMMLGIVFLFCDAPFMDECQTYLMVRSGRIPWGAG
                     QVLYIMLGTAIYFLFIVIISILILSPSLFLSNGWGKVLGTLAQTNAGQKYGILLPISYN
                     IQLQYTPIEALLLSFLLQWCAGTMVGLVMFIINIYLKRSIGAIVGSSIVLFDFVVANSL
                     PYYYYHFSPSSMARLTILDPTGMSPRPTNLYAYIFFIIGIIVLSVISVISVRKRQIEVL
                     PPV"
     CDS             complement(5180..5962)
                     /locus_tag="ctg1_2434"
                     /transl_table=11
                     /translation="MNRIIHTIFMDIRRAFISYGFWASVIAVCIFYYAASWNEMKIASD
                     GLYLFKYASEASGIGALVIILCVLPYTNSFCTDWNSQYIKFIAVRSGIKNYGVSKVISC
                     ALSSGCAIAIGMILFFISLMPWIKLVSTSAANFESFATQTLGGIYLSQGHYIMYFAVYV
                     YLAFLTGAFWSVVGLCASAYLPNKYVALCTPFIASSLINIVTYKFPVWLRLNRIAEGSF
                     IIKGTFFSLVYATVLYSILIICIGLLFVNSGKRRLSNG"
     CDS             complement(5973..7109)
                     /locus_tag="ctg1_2435"
                     /transl_table=11
                     /translation="MLKLNKALLSLTTIFFILTFSACTTEEIIKTDKSTKNNSTEVSGK
                     ELSADQSGKYKASLGNNIVVDAVVDKPNINNASILQVEDAVFDEKKLCDIFLGSSVVKK
                     EKSPYSTQYSIGGRILDIPFKAPFKVNTPLSKHIDTIVNTLQSGNLNKFKSQELPFMTK
                     EKAIEEARKVLMELSIIPYGSPTVYALDNKTIKQEQERLLREDKAFKDFVDMGKIRLKD
                     NWSNEDDSYYIFFRNSIRSIPCDPFGYAVTNTDIQAEGSEVSILISKNGIQSFFINGTV
                     YREKSVKKSNLPLITISQALISIEKKYSDVILSDKIVVSGISLVYSPVVTNSKGENRNI
                     ELIPTWLFNINQRESKGKEETQIYTNVRINAVDGKEIR"
     CDS             complement(7484..7867)
                     /locus_tag="ctg1_2436"
                     /transl_table=11
                     /translation="MKKLIMSGIVSLIILAISVPAFADTALFDFTLNPGQSGYSSFVHK
                     ADSEQRAYVSITSSNFINSDKTWFRVRDSADNIKTETKWANANISFTLNYISTGYAGDY
                     YRLKGQQDSASPYYVHVAGRWTP"
     CDS             8199..8768
                     /gene_functions="biosynthetic (rule-based-clusters)
                     cyclic-lactone-autoinducer: AgrB"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg1_2437"
                     /sec_met_domain="AgrB (E-value: 2.8e-38, bitscore: 129.0,
                     seeds: 181, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MINKCAFKITEYIKYNSDISNSDDLDKINYVLQVILGELFKIIIL
                     ILVFSILGRLHYFLFSMIVLISTRIFIGGYHCKTTLRCLLSSAFFFIITSLIVSSFSNV
                     NALVYYGISILSILIIILYAPFPNFKRPVKTEKRRYNLKLISVFSVLTWICILLFKVDN
                     PSYLNCGFSTILLEVLQIFLLGGENK"
     PFAM_domain     8220..8747
                     /aSDomain="AgrB"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF04647.17"
                     /description="Accessory gene regulator B"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_2437_0154"
                     /evalue="6.70E-38"
                     /label="ctg1_2437"
                     /locus_tag="ctg1_2437"
                     /protein_end="183"
                     /protein_start="7"
                     /score="130.0"
                     /tool="antismash"
                     /translation="KITEYIKYNSDISNSDDLDKINYVLQVILGELFKIIILILVFSIL
                     GRLHYFLFSMIVLISTRIFIGGYHCKTTLRCLLSSAFFFIITSLIVSSFSNVNALVYYG
                     ISILSILIIILYAPFPNFKRPVKTEKRRYNLKLISVFSVLTWICILLFKVDNPSYLNCG
                     FSTILLEVLQIFL"
     CDS             8765..8905
                     /locus_tag="ctg1_2438"
                     /transl_table=11
                     /translation="MINKKLHKSILNKAGFCLIAVASFITVSSSLFLLGEPTPPKSLYN
                     D"
     CDS             complement(9081..10349)
                     /locus_tag="ctg1_2439"
                     /transl_table=11
                     /translation="MIEFIKTFSNIFIELITIIFLWSKLFLKEESNLSKNLSVIFISSI
                     AVTFIDLMDINTVFGFLITIFAIKFLYCKKLIKTILEFVILGAVLIILQLIGIFFLQQY
                     INEMYSERFMSDITINILILIIAILGYYLIFNKRKKSIQIIDSKVIYYFSINIGMCLII
                     SKIIWEYNKNIILYNVMIYIVCLVIIFLVQIYLFIYISKIIEEKRVLEVQKEYSSIIEA
                     TIDEVKRKQHDFKNYINTINGMIEVTDEKLLKSQLKEYIKSSISANKNIEDILYINNTI
                     IKAIVYNKKCEAERLKIKFLYNVKDKYLENKLRDYEISDILGNLLNNAFEAVQIQEEYK
                     NNIKTVILNILIENNKSIIEVKNNGIPIKEEQINSIFKSGFSTKEGKNRGYGLYNVKKI
                     VKGKGGDIQMFFDEDYTVFKIII"
     PFAM_domain     complement(9084..9407)
                     /aSDomain="HATPase_c_5"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF14501.8"
                     /description="GHKL domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_2439_0155"
                     /evalue="9.50E-12"
                     /label="ctg1_2439"
                     /locus_tag="ctg1_2439"
                     /protein_end="422"
                     /protein_start="314"
                     /score="44.8"
                     /tool="antismash"
                     /translation="DYEISDILGNLLNNAFEAVQIQEEYKNNIKTVILNILIENNKSII
                     EVKNNGIPIKEEQINSIFKSGFSTKEGKNRGYGLYNVKKIVKGKGGDIQMFFDEDYTVF
                     KIII"
     CDS             complement(10374..11108)
                     /locus_tag="ctg1_2440"
                     /transl_table=11
                     /translation="VKNILVAEDDIKQCENLKKMLYMIDAEFNIHEAQDKDQALKISNN
                     VHIDLFFIDISLKNSSGLELALDLRKISRYEFSWMVFLTTHVEYLTQAFKQAHCYDYIV
                     KPYDKDEIISMIKKFSAHAKNNSVQEKERKSVFLDLKSGVSMKFYIDEIIFIESSMRTC
                     IVNTIRDSYTLKKVSLKNILKLINCNYIIQSYKSFLVNINYIKFIEKIDSRLSELYFEK
                     SSKKALLGYKFKNSVLEKLKGK"
     PFAM_domain     complement(10389..10667)
                     /aSDomain="LytTR"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF04397.17"
                     /description="LytTr DNA-binding domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_2440_0157"
                     /evalue="1.20E-06"
                     /label="ctg1_2440"
                     /locus_tag="ctg1_2440"
                     /protein_end="240"
                     /protein_start="147"
                     /score="28.8"
                     /tool="antismash"
                     /translation="FYIDEIIFIESSMRTCIVNTIRDSYTLKKVSLKNILKLINCNYII
                     QSYKSFLVNINYIKFIEKIDSRLSELYFEKSSKKALLGYKFKNSVLEK"
     PFAM_domain     complement(10761..11099)
                     /aSDomain="Response_reg"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00072.26"
                     /description="Response regulator receiver domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_2440_0156"
                     /evalue="4.60E-16"
                     /label="ctg1_2440"
                     /locus_tag="ctg1_2440"
                     /protein_end="116"
                     /protein_start="3"
                     /score="59.1"
                     /tool="antismash"
                     /translation="ILVAEDDIKQCENLKKMLYMIDAEFNIHEAQDKDQALKISNNVHI
                     DLFFIDISLKNSSGLELALDLRKISRYEFSWMVFLTTHVEYLTQAFKQAHCYDYIVKPY
                     DKDEIISMI"
     CDS             complement(11361..12014)
                     /locus_tag="ctg1_2441"
                     /transl_table=11
                     /translation="MGLWFVVILLIAIVSNTDSLAVGISYGTRNILIPFLSNILIALIG
                     GIGTLMSMYIGKGISAILNPKIAGYMGSAIIIIVGVWICIGEIKNNMKKSSAEEKEKTS
                     GTGLSSYSFFGRIPKVLENPFLADWDFSGYISVKESLVLGIALAVNNMANGIGAGMAGI
                     NPVITSIVAFLVSLFAIWIGIKLGHEYVHRWLGKLAAPAAGIILILIGIYEIFF"
     aSDomain        complement(11370..11996)
                     /aSDomain="TIGR02840"
                     /aSTool="tigrfam"
                     /description="spore_YtaF: putative sporulation protein
                     YtaF"
                     /detection="hmmscan"
                     /domain_id="TIGRFam_ctg1_2441_0042"
                     /evalue="1.80E-53"
                     /identifier="TIGR02840"
                     /label="ctg1_2441"
                     /locus_tag="ctg1_2441"
                     /protein_end="215"
                     /protein_start="6"
                     /score="179.0"
                     /tool="antismash"
                     /translation="VILLIAIVSNTDSLAVGISYGTRNILIPFLSNILIALIGGIGTLM
                     SMYIGKGISAILNPKIAGYMGSAIIIIVGVWICIGEIKNNMKKSSAEEKEKTSGTGLSS
                     YSFFGRIPKVLENPFLADWDFSGYISVKESLVLGIALAVNNMANGIGAGMAGINPVITS
                     IVAFLVSLFAIWIGIKLGHEYVHRWLGKLAAPAAGIILILIGIYEI"
     PFAM_domain     complement(11379..11618)
                     /aSDomain="Mntp"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF02659.17"
                     /description="Putative manganese efflux pump"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_2441_0158"
                     /evalue="6.50E-08"
                     /label="ctg1_2441"
                     /locus_tag="ctg1_2441"
                     /protein_end="212"
                     /protein_start="132"
                     /score="32.6"
                     /tool="antismash"
                     /translation="GYISVKESLVLGIALAVNNMANGIGAGMAGINPVITSIVAFLVSL
                     FAIWIGIKLGHEYVHRWLGKLAAPAAGIILILIGI"
     CDS             12325..12720
                     /locus_tag="ctg1_2442"
                     /transl_table=11
                     /translation="LDKYEQLLQTLVTEISGIKNELGGIKSEISNIKEDISDLKSGQQR
                     LEGNQQRLEVNQQKLEENQQKFQTDMNEVKSDIKELKAIVSDLEPKNANRHLEIEQDLT
                     EIKNNLKKLEVVTGLNCVDITYLKSVK"
     CDS             complement(13047..16694)
                     /locus_tag="ctg1_2443"
                     /transl_table=11
                     /translation="MKCSIKDLLDKKIVILDGAMGTCIQSFRLEEEDYRGNLQCNINQK
                     GNNDILNITKPEIIKEIHRQYFEAGADVVETNTFNGTSISQSDYGMEDKIYEINFNGAR
                     LAREVADDFNSKDPEKPRFVAGSVGPTNRTASLSPDVENPGFRNVTFDELSKAYGDQIE
                     GLIDGGVDFIIIETIFDALNARTAIFAAKNAFEKKGIKLPIMISGTIADKSGRILSGQT
                     LEAFAETMRDEDVLIIGLNCSFGAKDLIPFIRQLSKTQNKYISFYPNAGLPNSMGEYDE
                     HPDDTAAFVKEIAREGHINIVGGCCGTTPDHIKAISKAVSDVQPRRIPELEMETVFCGL
                     EALKINKSNNFVNVGERTNVAGSAKFARLIREKKYEEALTVAKNQVENGAQIIDVNFDD
                     ALLDAKTEMDTFLKLVASEPEISRVPIMIDSSKFEVLEAGLKAIQGKAIVNSISLKVGE
                     EEFIRQAQLIKKYGAGAVVMAFDEKGQADTYERRISICKRAYDILVNKVGFLPCNVIFD
                     PNILAIATGIEEHNNYAVDYINTTKWIKENLPYAKVSGGVSNLSFSFRGNNVIREAMHS
                     VFLYHAIKAGMDMGIVNPGMIQIYDEIDKDLLEKVEAVVLNKTPNAAEELVEFAENYKA
                     AEGKENDNKHSWRDKDCKERLTHALVKGIVEYIDEDVEECRVQHHRALEVIEGPLMDGM
                     KTVGKLFGEGKMFLPQVVKSARVMKKAVSFLLPYIEEEKKEGGSTSAGKVVFATVKGDV
                     HDIGKNIVSVVLSCNNFEVVDLGVMVPAETILETAKKEKADIIALSGLITPSLEEMANV
                     AEEMEQQGFKIPLMVGGATTSKTHTALKIETQYSNGVVHTTDASKAVEAAKKLVDPEKR
                     EAYIKEVQQEYKNIRENYSKIDRKLVTIEEAREKSLKLDWNKDIVETPNFTGIKKFLNF
                     PIKELRKYIDWTFFFIAWDMGMIYPKIMEDPKYGEEAKKLYKDANDMLDILERENILTA
                     NAVFGIFPANSVGDNIELYSGDKAETFNMLRQQEVSKKNVYRCLSDYVAPKESGIKDYI
                     GGFIATAGIGAAEYANRLKEKGDEYGAAMVKILADRLAEAFSEYLHMEVRKNYWGYSPH
                     ENIEISKVLKGDYMGIRPAFGYPSLRDHAEKTKLFDILDPERELGINLTDSYMMNPVAS
                     TCGLYFGNKEAKYFDINKIGKDQVDDYAKRNNKEYREIERVLNTILIYK"
     PFAM_domain     complement(13104..13901)
                     /aSDomain="Met_synt_B12"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF02965.19"
                     /description="Vitamin B12 dependent methionine synthase,
                     activation domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_2443_0163"
                     /evalue="5.90E-108"
                     /label="ctg1_2443"
                     /locus_tag="ctg1_2443"
                     /protein_end="1197"
                     /protein_start="931"
                     /score="360.5"
                     /tool="antismash"
                     /translation="IKELRKYIDWTFFFIAWDMGMIYPKIMEDPKYGEEAKKLYKDAND
                     MLDILERENILTANAVFGIFPANSVGDNIELYSGDKAETFNMLRQQEVSKKNVYRCLSD
                     YVAPKESGIKDYIGGFIATAGIGAAEYANRLKEKGDEYGAAMVKILADRLAEAFSEYLH
                     MEVRKNYWGYSPHENIEISKVLKGDYMGIRPAFGYPSLRDHAEKTKLFDILDPERELGI
                     NLTDSYMMNPVASTCGLYFGNKEAKYFDINKIGKDQVDDYAKRN"
     aSDomain        complement(13149..16670)
                     /aSDomain="TIGR02082"
                     /aSTool="tigrfam"
                     /description="metH: methionine synthase"
                     /detection="hmmscan"
                     /domain_id="TIGRFam_ctg1_2443_0043"
                     /evalue="0.00E+00"
                     /identifier="TIGR02082"
                     /label="ctg1_2443"
                     /locus_tag="ctg1_2443"
                     /protein_end="1182"
                     /protein_start="8"
                     /score="1771.5"
                     /tool="antismash"
                     /translation="LDKKIVILDGAMGTCIQSFRLEEEDYRGNLQCNINQKGNNDILNI
                     TKPEIIKEIHRQYFEAGADVVETNTFNGTSISQSDYGMEDKIYEINFNGARLAREVADD
                     FNSKDPEKPRFVAGSVGPTNRTASLSPDVENPGFRNVTFDELSKAYGDQIEGLIDGGVD
                     FIIIETIFDALNARTAIFAAKNAFEKKGIKLPIMISGTIADKSGRILSGQTLEAFAETM
                     RDEDVLIIGLNCSFGAKDLIPFIRQLSKTQNKYISFYPNAGLPNSMGEYDEHPDDTAAF
                     VKEIAREGHINIVGGCCGTTPDHIKAISKAVSDVQPRRIPELEMETVFCGLEALKINKS
                     NNFVNVGERTNVAGSAKFARLIREKKYEEALTVAKNQVENGAQIIDVNFDDALLDAKTE
                     MDTFLKLVASEPEISRVPIMIDSSKFEVLEAGLKAIQGKAIVNSISLKVGEEEFIRQAQ
                     LIKKYGAGAVVMAFDEKGQADTYERRISICKRAYDILVNKVGFLPCNVIFDPNILAIAT
                     GIEEHNNYAVDYINTTKWIKENLPYAKVSGGVSNLSFSFRGNNVIREAMHSVFLYHAIK
                     AGMDMGIVNPGMIQIYDEIDKDLLEKVEAVVLNKTPNAAEELVEFAENYKAAEGKENDN
                     KHSWRDKDCKERLTHALVKGIVEYIDEDVEECRVQHHRALEVIEGPLMDGMKTVGKLFG
                     EGKMFLPQVVKSARVMKKAVSFLLPYIEEEKKEGGSTSAGKVVFATVKGDVHDIGKNIV
                     SVVLSCNNFEVVDLGVMVPAETILETAKKEKADIIALSGLITPSLEEMANVAEEMEQQG
                     FKIPLMVGGATTSKTHTALKIETQYSNGVVHTTDASKAVEAAKKLVDPEKREAYIKEVQ
                     QEYKNIRENYSKIDRKLVTIEEAREKSLKLDWNKDIVETPNFTGIKKFLNFPIKELRKY
                     IDWTFFFIAWDMGMIYPKIMEDPKYGEEAKKLYKDANDMLDILERENILTANAVFGIFP
                     ANSVGDNIELYSGDKAETFNMLRQQEVSKKNVYRCLSDYVAPKESGIKDYIGGFIATAG
                     IGAAEYANRLKEKGDEYGAAMVKILADRLAEAFSEYLHMEVRKNYWGYSPHENIEISKV
                     LKGDYMGIRPAFGYPSLRDHAEKTKLFDILDPERELGINLTDSYMMNPVASTCGLYFGN
                     KEAKYFDI"
     PFAM_domain     complement(14184..14468)
                     /aSDomain="B12-binding"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF02310.21"
                     /description="B12 binding domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_2443_0162"
                     /evalue="1.40E-20"
                     /label="ctg1_2443"
                     /locus_tag="ctg1_2443"
                     /protein_end="837"
                     /protein_start="742"
                     /score="73.6"
                     /tool="antismash"
                     /translation="KVVFATVKGDVHDIGKNIVSVVLSCNNFEVVDLGVMVPAETILET
                     AKKEKADIIALSGLITPSLEEMANVAEEMEQQGFKIPLMVGGATTSKTHT"
     PFAM_domain     complement(14520..14735)
                     /aSDomain="B12-binding_2"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF02607.19"
                     /description="B12 binding domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_2443_0161"
                     /evalue="1.30E-23"
                     /label="ctg1_2443"
                     /locus_tag="ctg1_2443"
                     /protein_end="725"
                     /protein_start="653"
                     /score="83.3"
                     /tool="antismash"
                     /translation="ERLTHALVKGIVEYIDEDVEECRVQHHRALEVIEGPLMDGMKTVG
                     KLFGEGKMFLPQVVKSARVMKKAVSFL"
     PFAM_domain     complement(14916..15632)
                     /aSDomain="Pterin_bind"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00809.24"
                     /description="Pterin binding enzyme"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_2443_0160"
                     /evalue="7.30E-55"
                     /label="ctg1_2443"
                     /locus_tag="ctg1_2443"
                     /protein_end="593"
                     /protein_start="354"
                     /score="186.4"
                     /tool="antismash"
                     /translation="GERTNVAGSAKFARLIREKKYEEALTVAKNQVENGAQIIDVNFDD
                     ALLDAKTEMDTFLKLVASEPEISRVPIMIDSSKFEVLEAGLKAIQGKAIVNSISLKVGE
                     EEFIRQAQLIKKYGAGAVVMAFDEKGQADTYERRISICKRAYDILVNKVGFLPCNVIFD
                     PNILAIATGIEEHNNYAVDYINTTKWIKENLPYAKVSGGVSNLSFSFRGNNVIREAMHS
                     VFLYHAIKAGMDMGIVN"
     PFAM_domain     complement(15735..16655)
                     /aSDomain="S-methyl_trans"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF02574.18"
                     /description="Homocysteine S-methyltransferase"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_2443_0159"
                     /evalue="4.20E-79"
                     /label="ctg1_2443"
                     /locus_tag="ctg1_2443"
                     /protein_end="320"
                     /protein_start="13"
                     /score="266.4"
                     /tool="antismash"
                     /translation="VILDGAMGTCIQSFRLEEEDYRGNLQCNINQKGNNDILNITKPEI
                     IKEIHRQYFEAGADVVETNTFNGTSISQSDYGMEDKIYEINFNGARLAREVADDFNSKD
                     PEKPRFVAGSVGPTNRTASLSPDVENPGFRNVTFDELSKAYGDQIEGLIDGGVDFIIIE
                     TIFDALNARTAIFAAKNAFEKKGIKLPIMISGTIADKSGRILSGQTLEAFAETMRDEDV
                     LIIGLNCSFGAKDLIPFIRQLSKTQNKYISFYPNAGLPNSMGEYDEHPDDTAAFVKEIA
                     REGHINIVGGCCGTTPDHIKAISKAV"
     CDS             17210..17848
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1101:phosphoglycerate mutase (Score: 134; E-value:
                     8.2e-41)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg1_2444"
                     /transl_table=11
                     /translation="MSTSIMLIRHGETEWNALGKFQGSKDIDLSKEGILQAEFLKNRFK
                     KNFDYIYCSPLKRALKTAKIISEDMNLHPIIYPQLREIDFGEWEGLTVKDIKNNYPELF
                     KLWLIDDTTGPLCGGDGSLKKASIRATDAILEIVKENKNKNIAVVAHGGIIKAALIGIF
                     NWNMSMYHKIRLGNTSITRLYFDDNMNPLILCLNDTSHLPDDYNIKSYV"
     PFAM_domain     17222..17800
                     /aSDomain="His_Phos_1"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00300.24"
                     /description="Histidine phosphatase superfamily (branch 1)"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_2444_0164"
                     /evalue="4.00E-54"
                     /label="ctg1_2444"
                     /locus_tag="ctg1_2444"
                     /protein_end="197"
                     /protein_start="4"
                     /score="183.3"
                     /tool="antismash"
                     /translation="IMLIRHGETEWNALGKFQGSKDIDLSKEGILQAEFLKNRFKKNFD
                     YIYCSPLKRALKTAKIISEDMNLHPIIYPQLREIDFGEWEGLTVKDIKNNYPELFKLWL
                     IDDTTGPLCGGDGSLKKASIRATDAILEIVKENKNKNIAVVAHGGIIKAALIGIFNWNM
                     SMYHKIRLGNTSITRLYFDDNMNPLILCLN"
ORIGIN
        1 ctaatatatt attccataat ttactgctga acttttatgt gtaatctcga ttttcgccca
       61 gctattagga cctgcactat ctctaccaga tccaccacct ccatttgaaa ctgctgcatc
      121 atgctggtag tcataatgaa ttgcatgtac ataatcttca tttatccaag atgtgttata
      181 tccatatata tatttatacc tagaactagt tacagaagct tcccaatcat tattaaagct
      241 atgtcctgca ctagttacca tatcagtagt agctttggca tttgtatatg gaacaagtat
      301 tgctaaaaga gctaaaacag caattatttt ttttgatttt ttcatataaa atttcctcca
      361 taaattaata ttttgctaat ttaatatgac aaaataactg tacaatcaaa tttttggatt
      421 tcaaaatatt ttgtatagat acgtacctta cacatttatt cttacataaa gttcactaaa
      481 tttaaaccta ttatgtacaa actgttaatt ttcaagcata aactgcaata tatttgtgat
      541 atcatttcat gttctactta agagatattg ataaattatt aagggctgtc atatgttatt
      601 tccactgagt atagactaat tttatgttag tctgtccaat tacctttcat attcaataga
      661 taaagtttat tttcatacat tccaaaagat aaatacattg gctgatatct aactgataat
      721 ctggttatca ctatatcatg ttctctcaac tgcaatgtat aatcatcctc ataacctaag
      781 ctttgaagta tctcctttgc tgccttagaa gcctcttctc taactgattc gttatttaaa
      841 gctgcactgg attttgtatt aaaatctaac atttgaaaac ctaaaagttc accacttgga
      901 gatataaaat attcaccacc agtatagtaa gttttttcag atggattttt tgctcttaat
      961 tctaatctcc aaaaatcctt atttctttga agtatattta ccttataatc ctgaaaattg
     1021 ctgccaaaaa gtagtttttc atattttttt gccatgtttt ctgcatcttt atcatttttt
     1081 actaatataa tacttttcac tttagtatct tctaataaag cttgaatttc aaagccgctt
     1141 atcttatgga ttacacctat attcttattg ttaacactca tcaacagata aggtattatt
     1201 ctcctgctga atataactgt cagtataacc acaagaaaca gtgctattgt tataaataat
     1261 gtattattac agtaaattat tttcttttta taattctgtt tcaccaccgc ttttcccctt
     1321 tttaaaaata attgatacac aagtaccttt attttcctca cttttaatat tcataacagc
     1381 atgatgtaat acaacaattt cattacaaag agttaagcca agacctgcac cattgtgttt
     1441 acgagttcta gatttatcca ccatataaaa tggttccatt atgtatgaca attccttttc
     1501 gggtattcca aaacctttat ctataatttc aataataatt ttatcatcct gttctttacc
     1561 cgcaagatag atttcatctc catatgtgct tgcctttata gaattatcca gtagatttat
     1621 cagtagagtt ttaaaaagat ctctttctat attgagagaa atatcatcac aatgaatttt
     1681 aagttcaata ttcttttcct ttaaacgtaa tttaagaatg tcatgcacct gttcaaatat
     1741 aatatccaat ggtgtagttt taagttcaag gtccccactt tttaggtgaa acatagtcat
     1801 aagcttatgg gccatagaag aaagtctttt cccttcactg gatatataat taagtccttc
     1861 atccatttca tagggttcct gctttactgt acgcataaga tcggcatagg ctataataga
     1921 tgtaagtggc gtttttaatt catgagtaaa gttttccaca aatctctgtc tctgttcagc
     1981 tatactttta agtttcttct ctctattatc tattgtttct gccataaggt ttatttgctc
     2041 agtcaagtga taaatttcat catttccaac caaaggtact cttctggaat aatccccttc
     2101 tgatatgtgc ttagtaatag tttcaagttt tctaagaggt ttagtaagta aatatgaaat
     2161 aatacctaat atacctgcag caagaataca aattatagag ccaaactcta taaaatcatt
     2221 tattttttta ttttgatagt tatattcttc agtaatatta tttatggtat aaagattaaa
     2281 ggaatcatct ccaactttaa agctattccc agcaataatc actctgtcct tatctaactt
     2341 atacatacca taagaaatat ctttatcaag cttattcata gtattttcta tgttattttt
     2401 tattgtatca ctggtatttg aaaaaataat ttcattattg gaatttgtta ctataacctg
     2461 ccttgaatta tctcctgtat gggtaagctt taatataata tctgattggt aaaccttata
     2521 tatatctggt gagtctgcca gttgattttt ccaataaaca agactggtat atagagactg
     2581 ctgaaaggat tgatgagcta aaagtgcaac ggaattttct ctttttacca tatcactata
     2641 atctctgcta agccatagta tgccaatcac attgaaagat aagaatagca caatatatcc
     2701 gctaagaaaa attttttgcc aaaatctcat attttactcc aatctatagc ctgttttaaa
     2761 aattgtttta atttcatttt tccatcctaa tttttttctt atgcgctgca catgagcatc
     2821 tatagttctt gtttctccca taaaatcata accccatacc ttttgcatga gaacttctct
     2881 tgtcaaagca atatgcctgt tctttatgaa taaaatcaac aattcatatt ccttaggcag
     2941 caattctatc tgtttaccat tctttataac ttcatgacta tctaaattaa tttctacatc
     3001 accataaaca attttatttg taagtttgtt atttctgttt agtacagctc ttatacgtgc
     3061 caataattcc tgatattcaa aaggttttgt aatataatca tctgcaccta atctaaaacc
     3121 ctgaagctta tctgtcagtt catccttagc tgttaaaaag attacagaaa tattcttagg
     3181 tttaagaatt tttatcaaat caaaaccatt tagataagga atcataacat ccaataatac
     3241 taaatcgaat ttatctgttt caattttatg taaagcctct tgtccattat aagctgtttc
     3301 tgtatcatat ccggctactt ttaaatattt gcatattaca tttgaaatag gtatttcatc
     3361 ttccactact agaatattgt tcattgaatc acctgctttt ttcatagata tgtacaatat
     3421 tatagcattt actgttacgt cagacagact ttttatttaa attttacaaa ataaatacat
     3481 cctagctttt tgggtaactt aaaaagggat gttgaaaaag catccctttc tcttataaac
     3541 tgctcttcta aattgtatat tgattaccaa agtatactac tatgaacatc tttcactatt
     3601 tcccgttacc tatgattcaa aaatatatag aaattttgtt gcatatttct tatctaagga
     3661 cagtgagtac ccctgaatcc atttcactta cagtatcgca aagcatttca atgtcttctg
     3721 cactgtggct ggcaagtata atggttttcc cttcatcccg tagtttaatc aataattcac
     3781 gcatatcctt taccccatgt ttatcaatgc cgtttaatgg ttcatccaat agtaaaatag
     3841 atggattctc cattatagcc tgagccatac ctaatctttg acgcatcccg agagagtatt
     3901 tccctaccca ctttttactt tcaggatcaa gtccaactcg ctttataact gatttaatat
     3961 cttttttatc aataatatta ttaatagaag caagaaattt cagattttta taaccattat
     4021 aatttggtaa aaaccctgga gtttctataa ttatccctac atctttagga acatctgtat
     4081 cctttccaat ccttttgtca tttacaatta tttcgccaga agttataggt acaaaaccac
     4141 atatacattt taaaagcatt gttttaccag aaccatttcg tccaattaaa ccatgtatct
     4201 tgtttttctc aaaatttata gaaacatttt ttaaaacctg attttcttta aatgctttgc
     4261 aaacatcatt aacacatact gccaaattat tcatgcacga ttcctccttt atttttatgt
     4321 tctttcaaaa ttttaaactg gcggaagcac ttctatctgc cgcttacgta ctgatataac
     4381 tgaaatgacg cttagcacta ttataccaat gataaagaat atgtaagcat aaaggtttgt
     4441 aggccttggt gacattcccg ttgggtcaag tattgttaac cgcgccatgg aggatggtga
     4501 aaaatgatag tagtaataag gcaagctatt tgcaactacg aaatcaaata gcacaataga
     4561 agaaccaact atggcaccaa ttgaacgctt taaataaata tttattataa acatcacaag
     4621 tccaaccata gtacctgcac accattgtag tagaaagctt agtaaaagag cttctatggg
     4681 agtatattgc aattgtatat tataacttat tggtaaaagt attccatatt tttgacctgc
     4741 atttgtttga gctaaagtgc caagcacttt tccccaacca ttacttaaaa ataagcttgg
     4801 agataatatt aatatactta taatcacaat aaataaaaaa taaatagctg tacccaacat
     4861 tatatataga acctgacctg caccccaagg tatacgtcca cttcttacca taagataggt
     4921 ctgacattca tccataaagg gtgcatcaca gaagaggaag actataccca gcatcattag
     4981 catctgtgta aaataccagt ttgatatata tggaaataac caaggtgcaa ctctataatt
     5041 tacaatttta gaaaaactta atataggatt gacatagttc catagcatca aaaaaagtaa
     5101 tgcagctaaa atataaattc gaggatttga tgcccatttt ctaatgttat taatggatat
     5161 aaaaaaagtt ttttgtaaat tagccattag ataacctcct ttttccacta ttcacaaata
     5221 ataaaccaat acaaattata agtatactat acaacactgt agcatatacc aaactaaaaa
     5281 aagttccctt tattataaag cttccttcag ctattctatt taatcttaac catacaggaa
     5341 atttgtaggt gactatattg atcaaagagg atgcaataaa aggtgtgcac aatgcaacat
     5401 atttattggg aagataagcg gatgcgcaaa gtcctacaac agaccaaaat gcacctgtaa
     5461 ggaaagcaag atatacatat actgcaaaat acataatata atgcccctgc gaaaggtaaa
     5521 taccacctaa agtttgagta gcaaaagatt caaaatttgc tgcagaggtt gaaacaagtt
     5581 ttatccatgg catcagggat ataaaaaaca atatcattcc tatggctata gcacagccag
     5641 aggataatgc acagctaata acctttgaga caccataatt ttttatacca ctgcgtactg
     5701 ctataaattt tatatattga ctattccaat cagtacaaaa actattagtg tatggtaata
     5761 cacataatat tattaccaaa gcacctatac cacttgcttc agaagcatat ttgaaaagat
     5821 aaagaccgtc tgacgcaatt ttcatttcat tccatgaagc tgcatagtaa aaaatacata
     5881 cggcaattac agatgcccaa aaaccatagg atataaaagc tctccgtata tccatgaata
     5941 tagtgtgaat aatacgattc ataaaaatcc tcctaacgaa tttcctttcc atctactgca
     6001 ttgatacgaa cattagtata aatttgtgtc tcttctttcc ctttactttc tctctgatta
     6061 atattaaaaa gccatgtagg tattaattct atatttcgat tttccccttt tgaattagtt
     6121 actacaggtg aatacactaa agatatacca gacactacta ttttatctga taatatcacg
     6181 tcagaatatt ttttttcaat actgataagt gcctgagata ttgtaattaa aggtaaatta
     6241 ctttttttta cggatttctc acgatatact gtaccattta taaaaaaaga ttgtatacca
     6301 tttttagaaa taagtatact tacctcacta ccttctgcct gaatatcagt atttgtaact
     6361 gcataaccaa atggatcaca aggaatactt ctaatagagt tacgaaaaaa tatataatag
     6421 ctgtcatctt cgttgctcca gttatctttc agtcttatct ttcccatatc tacaaaatcc
     6481 ttaaaagctt tatcctccct aagaagtcgc tcctgctctt gcttaatagt tttattgtct
     6541 aatgcataaa cagtaggcga accataagga ataatactta gctccatcaa aactttacgt
     6601 gcctcttcaa ttgctttttc ctttgtcata aatggaagtt cttgagattt aaatttatta
     6661 agattaccac tttgtaatgt gttaacaatg gtatcaatat gttttgataa aggtgtatta
     6721 actttaaatg gagctttaaa aggaatatca agtattcttc ccccaataga atattgtgta
     6781 ctatatggag atttttcttt ttttactaca ctagaaccta aaaatatatc acatagcttt
     6841 ttttcgtcaa atacagcatc ttcaacttgt aatatagatg cattatttat atttggcttg
     6901 tctaccacag catctaccac tatattattt cctagtgatg ccttatattt tcccgactga
     6961 tctgcactta attctttacc acttacctct gtactattat tttttgtact tttatccgtt
     7021 tttataattt cctcagtggt acatgctgaa aacgtgagaa taaaaaaaat tgttgttaaa
     7081 cttaataagg ccttgtttaa ttttaacatt agcttaatga acctcccgct ttgtaaatga
     7141 aatttataag taatttataa tcacttgtat tatggtatca atttactttt ataaagtttt
     7201 catggaaatg ttgtgaaatt gtaaaaatta tttattatat agaaatttat atattttttg
     7261 tacattacta caaccgttaa tataacaata aaaaaggtac tatcgttatc atcaatgttt
     7321 tcttataaat aaattaaaat tcataagaat ataataattt tttatgattt attcattctt
     7381 acataattaa aaaattaata aaatcttaaa taggtttaag atttttatca taaaaaataa
     7441 atgatcaagc tgctagtaag cttgaccact tattttattg ttattatggt gtccaacgac
     7501 cagctacatg cacatagtaa ggactagctg aatcttgttg acctttaagt ctataataat
     7561 caccagcata tcctgttgat atataattca atgtaaaact tatatttgca ttagcccact
     7621 tagtttcagt ttttatatta tcagcagaat ctcttacacg aaaccatgtt ttatcactgt
     7681 ttataaaatt gctgctcgta atacttacat aagctcgttg ttcactatct gccttatgca
     7741 caaagctaga ataaccagat tgtcctggat taagtgtaaa atcaaataga gctgtatcag
     7801 caaaagctgg tacacttatt gctaatatta taagagaaac aatacctgac ataattaatt
     7861 ttttcatgtt tacccctcca tcataataat tttataccta atctgtattg tttattaact
     7921 agcataaaat atacagtaaa aggatctgat ttaataaaac agtgtaactt tatagaaaaa
     7981 tatttttatg tactgcttat ctacaaattt attttcacat aaaaatcacc aaatttaaac
     8041 ctattataca caaaacgtta atttctaaac ataaactgca gtatattttt taaaaataac
     8101 tgtttatgtt caaaaaatga cgtttcatgc cttgctcata tacatttgtt taaattttta
     8161 gtatcttaga agtcaaatga tacataaaag gtgataaaat gataaataaa tgtgcattca
     8221 agataactga atatataaag tacaatagtg atataagcaa ttctgatgat ttagataaaa
     8281 taaattatgt attacaggtt attttaggcg aactatttaa gataatcatc ttaattttag
     8341 tattttctat tttaggaagg ttacattatt tcttattttc tatgattgtt ttaatttcca
     8401 ctaggatttt cataggtggt taccattgta aaactactct gaggtgttta ttatcttcag
     8461 cattcttttt tataattaca tctttgatag tttcttcatt ttctaatgtt aatgcattag
     8521 tttattatgg aatttcaata ttgagtatac tgataatcat tttatatgca ccttttccga
     8581 attttaaaag gcctgttaaa acagaaaaaa gaaggtataa tttaaaattg atatcagttt
     8641 tttctgtgtt gacttggata tgtattttgt tatttaaagt tgataatcca agctatttaa
     8701 attgtggatt ctctacaatt ttattagaag ttcttcaaat ttttctactg ggaggtgaaa
     8761 ataaatgatt aataaaaaac tacataaatc catcttaaat aaggcaggct tttgtttaat
     8821 tgctgtagcc agctttataa ctgtgtctag ttctttattc cttctagggg aacctacccc
     8881 gcctaaaagt ttatataatg attaattttc tacattattt cctttcagcc taggtatata
     8941 cgatattctt attttaaatc tagtggaagt cttttacttt cactaaatag aatttatcct
     9001 gttacagcga cacgttccta gataatttat ctaaacttag ttggagttcg aactccaact
     9061 aagtaagatt cattgatgat ttaaatgata attttaaaga cagtgtaatc ttcatcaaaa
     9121 aacatttgaa tgtcaccacc ttttcctttc actatttttt tcacattgta cagtccatat
     9181 cctctatttt taccttcctt agtagaaaac ccacttttaa atatactatt aatctgttct
     9241 tcttttatgg gtattccatt atttttaact tctattatac ttttattatt ttcaattaat
     9301 atgttcaaaa taactgtttt aatattattt ttatattcct cttgaatctg taccgcttca
     9361 aaggcattat ttaaaagatt gccaagtata tctgatattt cataatctcg caacttattt
     9421 tctaaatact tatcttttac attgtataaa aactttattt taagtctttc tgcttcacat
     9481 ttcttattat atactatagc ttttattatt gtattattta tgtataatat atcttctata
     9541 tttttatttg cagaaattga tgatttaata tattctttta attgactttt taacagtttt
     9601 tcatccgtta cttcaatcat tccatttatg gtatttatat aatttttaaa atcatgctgt
     9661 tttctcttaa cttcatcaat ggtagcctct ataatggaac tatattcctt ttgtacttct
     9721 aacacccttt tttcttctat aatttttgat atatatataa acaaatatat ctgtactaaa
     9781 aagattatta ctaaacatac tatgtaaatc atcacattat ataaaataat atttttatta
     9841 tattcccata ttatcttgga tattattaaa cacattccaa tatttatgga aaaatagtat
     9901 ataactttag aatctataat ttgtatactt ttttttcttt tattgaatat taaatagtaa
     9961 cccaatatag ctataattaa aataagtata ttgattgtaa tatcactcat aaatctttct
    10021 gaatacattt cattaatata ttgctgtaga aaaaatatac ctattaattg cagtataata
    10081 agaactgcac ctaatattac aaattcaaga attgttttaa ttaatttttt acagtacaaa
    10141 aatttaattg caaatatggt aatcaaaaat ccaaaaacag tattaatatc catcaaatca
    10201 ataaaggtta ctgctattga acttataaaa attacagata gattttttga caggttactt
    10261 tcttctttta agaaaagttt agaccacaaa aatataattg taatcaattc aataaaaata
    10321 ttgctaaaag ttttaataaa ttcaatcatt ctatccccct tggttaatat aatttatttt
    10381 ccttttaatt tttccaaaac actattttta aatttatatc ccaaaagagc ttttttactg
    10441 gatttttcaa agtaaagctc acttaatctg gaatctatct tttcaataaa ctttatataa
    10501 ttaatattta ctaaaaaaga tttataactt tgaattatat aattacagtt tataagcttc
    10561 aatatatttt ttaaggatac tttctttaag gtgtaactgt cccttatagt atttactatg
    10621 catgtcctca tactgctttc aataaagatt atttcatcaa tataaaattt catgctgact
    10681 ccgcttttta agtcaagaaa tacagacttt ctttcctttt cctgaacaga attattttta
    10741 gcatgagcac taaatttttt aatcatactt ataatctcat ctttatcata gggcttaaca
    10801 atataatcat aacaatgtgc ctgtttaaaa gcctgagtta aatattctac atgagtagtt
    10861 aaaaaaacca tccaactgaa ttcatatcta gatatttttc taaggtcaag agcaagctct
    10921 aatcctgaag aattttttaa agaaatgtct ataaaaaata aatctatatg tacattattt
    10981 gaaattttta atgcctgatc tttatcctga gcttcatgta tattaaattc agcatctatc
    11041 atgtatagca ttttctttaa attttcacat tgtttaatat catcttctgc cactagaata
    11101 tttttcacta gatatatcac ctgcctgtag taatactaat ttaatatttt taacaataaa
    11161 aatatctatt taacaatttt tctatattta tatactatca tagcttttat tatatttaaa
    11221 atacactttt tgccaatata taatcaaaac aattacatat taacaatttt tatttattat
    11281 ggaactctat tttattgaca aaatctaagc ccaatttaaa taaaattcat aaattaagcc
    11341 tagacttatt aaaaaattcc ttaaaaaaat atttcataaa ttccgataag tataagtata
    11401 atgcctgctg caggtgcagc caattttcca agccagcggt gtacatattc gtgtcccagc
    11461 tttataccta tccaaattgc aaatagactt acaagaaatg caactattga agtgattaca
    11521 ggattgatcc ctgccatgcc ggctccaata ccatttgcca tattatttac tgccagggca
    11581 attcccagca ccaaactctc tttaacacta atataaccag aaaaatccca gtcagctaaa
    11641 aatggatttt ctaaaacctt tggaatcctg ccgaaaaaag agtaactgct gagacctgtc
    11701 cctgaggttt tttccttttc ttctgctgaa gacttcttca tattgttttt tatttcccct
    11761 atacagatcc aaactcctac tattattata attgccgatc ccatatatcc agcaatttta
    11821 gggtttaaaa tagctgatat tcccttacct atatacattg acataagagt tccaatacct
    11881 cctatcaatg ctataagtat atttgataaa aagggtataa gtatatttct tgtaccatag
    11941 gaaatcccaa cagctaaact atccgtatta ctaactattg ctataagtaa tattactaca
    12001 aaccataagc ccataaccag cttccaccct tcatattact acctatgagt tagtatatga
    12061 cgctagttat ttattggtta cctattacta tttagcaata atgctttcta taatttacca
    12121 aagtaaaatt gaagcaagtt cttaattcag gtggggattc ttttacacca tctgaatttt
    12181 agaactgcaa atacatggtt tacttggcgt tgagccccca cttgaaaaag ggggagactt
    12241 actccaagtt aatcaggtga aaaataatgc ttcaaaattg cttattaata atatataatt
    12301 agaatatcgg aggtgattcg taaattggat aaatatgagc agttgttaca aacattagtt
    12361 actgaaatca gtggaattaa aaatgaactt ggcggcatta aaagtgaaat cagtaacatt
    12421 aaagaggata tatccgactt aaaatcaggt cagcaaagac ttgaaggaaa tcagcaaagg
    12481 cttgaagtaa atcaacaaaa acttgaagaa aatcagcaaa aatttcaaac tgacatgaac
    12541 gaagttaagt cagatataaa agaactaaaa gctatcgtgt ccgacttaga acctaagaat
    12601 gctaatcgtc atttagaaat tgaacaggac ttaactgaaa taaaaaataa cttaaaaaaa
    12661 ttagaagttg taacaggttt aaactgtgta gatattacat atctaaaatc tgtaaaatag
    12721 taaggaggga aataatccct cctttttatc cgttcctata tagtacgcct aaatattgct
    12781 atctttacat tcataataat aaagcttaaa ataaccttca taggcttgct atgtgaattg
    12841 tagagatatc ctcgaataaa ttattagaaa aacttacctt ggcgactttg aaattcgtta
    12901 agtgactttt actgtttaaa cgaagtgagt ttaaaagtca tagaatttca aattaagcca
    12961 aggttagctt ttcttaatga aatgaaggat atcctaaatc acatagcaag cctgcttttg
    13021 aaggttattt taaagcttat tctcatttac ttataaatca atattgtatt taatactctt
    13081 tctatttctc tatattcttt attatttctc tttgcataat catctacctg atccttgcct
    13141 atcttgttta tatcaaaata ttttgcctct ttatttccaa aataaagtcc acaggtactg
    13201 gctacaggat tcatcatata gctgtcagtt aaatttattc ccaattccct ttctgggtct
    13261 aaaatatcaa agagctttgt cttttctgca tgatctctta aggatggata accaaaggct
    13321 ggtcttattc ccatgtaatc gcccttcagc acctttgaaa tttctatatt ttcatgagga
    13381 gaatatcccc aatagttctt tcttacttcc atgtgaagat attcagaaaa agcttctgct
    13441 aatctgtctg caagaatttt taccatggca gctccatatt catcgccttt ttctttcagt
    13501 ctgtttgcat attcagctgc acctatacca gccgtagcaa taaatccacc tatatagtcc
    13561 tttattccac tttccttagg ggctacataa tcagaaagac atctatatac atttttcttt
    13621 gaaacctcct gctgtcttag catattaaag gtttcagctt tatcaccact atataattca
    13681 atattatctc ctacggagtt cgcaggaaaa attccaaaaa cagcattagc agtgagtata
    13741 ttttctcttt ctaaaatgtc cagcatatca ttagcatcct tgtaaagttt ctttgcctct
    13801 tcaccatatt taggatcttc cataatttta ggatatatca ttcccatatc ccaggcaatg
    13861 aagaaaaatg tccaatctat atactttcta agctccttta ttggaaagtt gagaaatttt
    13921 ttaattccag taaagtttgg agtttccaca atatccttat tccagtcaag ttttaatgac
    13981 ttttctcttg cttcttctat agttacaagc tttctatcta ttttagaata attttctctt
    14041 atatttttat attcttgttg tacttccttt atatatgctt ctctcttctc tggatcaact
    14101 aatttttttg ccgcttccac tgcttttgag gcatctgtag tatgaactac tccattagaa
    14161 tactgtgttt caatttttaa tgctgtatga gttttagagg tagttgctcc acctaccatt
    14221 aaaggtattt taaagccctg ctgctccatt tcttcagcaa catttgccat ctcttctaag
    14281 gatggagtta taagcccact aagtgctatt atatctgcct tttccttttt tgcagtttcc
    14341 aaaatagttt ctgcaggtac cattactcca aggtcaacca cttcaaaatt gttacaggag
    14401 agaactactg atactatatt tttacctata tcatgtacat cacctttaac cgtagcaaag
    14461 acaacttttc ccgcactggt gctgcctccc tctttctttt cctcttcaat ataaggtagt
    14521 aaaaaactca ctgctttttt cataacccta gcacttttaa ctacctgagg aagaaacatc
    14581 tttccctctc caaataattt acctacagtt ttcattccat ccattaaagg tccttctatt
    14641 acttccaatg ctctatggtg ctgaactctg cattcttcta catcttcatc aatatactca
    14701 actatcccct ttacaagagc atgagttaat ctttctttgc aatctttatc tctccaggaa
    14761 tgtttattgt cattttcttt tccctctgca gccttataat tttctgcaaa ttctaccagt
    14821 tcctctgctg catttggtgt tttattcaat actactgctt ctactttttc aagaagatcc
    14881 ttatcaattt catcatatat ttgaatcatt ccagggttta caattcccat atccataccc
    14941 gcttttatag catgatacag gaatactgaa tgcattgctt ctcttataac attgtttccc
    15001 ctgaaagaga aggataaatt acttacccct ccgctcacct ttgcataagg aagattttcc
    15061 tttatccact ttgtagtatt tatataatct actgcataat tattatgttc ttctattccc
    15121 gtagcaatgg ccaaaatatt aggatcaaag ataacattgc aaggtaaaaa tcctacttta
    15181 tttactagta tgtcataggc tcttttacat atggaaattc ttctctcata agtatctgcc
    15241 tgaccttttt catcaaaggc cataactaca gctcccgctc catatttttt aatcaattga
    15301 gcctgcctta taaattcttc ttctcctacc tttagactta tggaatttac tatagcttta
    15361 ccttgaattg ccttaagtcc agcttcaagc acttcaaact ttgaagaatc tatcattatt
    15421 ggtactcttg agatttccgg ttcactggca acaagtttta aaaatgtgtc catttccgtt
    15481 ttagcgtcta aaagagcatc atcaaaattt acatctataa tctgtgctcc attttccact
    15541 tggtttttag ctaccgttag tgcttcttcg tatttctttt cccttataag tcttgcaaat
    15601 tttgcagaac cggctacatt tgttctctct cccacattta caaaattatt tgatttattt
    15661 atctttagag cttcaagacc gcaaaagaca gtttccattt caagttctgg aattcttctc
    15721 ggctgtacat cgctgacggc tttacttatg gctttaatat ggtcaggtgt agttccacag
    15781 cagccaccta caatattaat gtgcccttcc cttgcaattt cttttacaaa tgctgcagta
    15841 tcgtcaggat gttcatcata ttctcccatg gaattaggca gacctgcatt aggataaaaa
    15901 cttatatatt tattttgagt ttttgacaac tgccttataa agggaataag atcctttgct
    15961 ccaaaagaac aattgagtcc tataatgagt acatcctcat ctctcatagt ctctgcaaaa
    16021 gcttcaagag tctgcccaga taaaattctt ccgcttttat ctgcaatagt tcctgaaatc
    16081 attataggaa gttttattcc ctttttttca aatgcatttt ttgcagcaaa tatggcagtt
    16141 cttgcattta gagcatcaaa tatagtttct ataattataa aatccacacc accatctata
    16201 agtccttcta tctgatctcc ataagccttt gaaagttcat caaaagttac atttctaaag
    16261 cctggatttt ctacatctgg tgaaagggaa gccgttctat ttgtaggtcc tacagagcca
    16321 gctacaaaac gaggtttttc aggatctttg ctgttaaaat catcagctac ttctcttgca
    16381 agccttgctc cattaaaatt tatctcatat attttatctt ccataccata atcactttga
    16441 gagatgctgg ttccattaaa agtatttgtt tcaactacat ccgcaccagc ttcaaaatat
    16501 tgcctatgta tttcttttat tatctctggt tttgtaatgt ttaatatatc attgtttccc
    16561 ttctgattta tattacactg aaggtttcct ctataatctt cttcttccag tctaaagctt
    16621 tgaatacaag tacccattgc tccatcaagt atcacaattt ttttatcaag taaatcttta
    16681 atactgcact tcataaatag caagccccct aacctgtaaa taacgtaaat ttaatattat
    16741 aaatagacta aacatcttat atagattttc caagtgtaaa atcaaaaata aaaactgcct
    16801 ctcctaagaa aagcagtaaa taacgcatac tcacttcttc tcttatcttt cagaaaacct
    16861 ctgctggaat taacaccgcc acattttcca ttaaatgccg gttgtcgggt ttcatagggc
    16921 cagtccctcc acctctcttg ataagattaa aaattaaaat tattaaattt ctttatttca
    16981 tatgatatat atttttcaca taactgtcaa tggattttac aaaaattatt aatagaattt
    17041 tatttaaatt tattttactt agcattatca gtattatatt atgtatatat ttttataact
    17101 tcactttata tgttaaactt aaaatataaa attctaaagc ttgacaattt aattatatga
    17161 tttatgctta tgataattaa taaaaacaaa taatacatgg aggttttgaa tgagcacttc
    17221 aataatgcta ataagacacg gagaaactga atggaatgcc ttaggaaaat ttcaaggaag
    17281 taaagatata gatttgtcaa aagagggtat attacaagca gaatttttaa agaacagatt
    17341 taaaaaaaat tttgactata tatattgtag tccattaaag agagctttaa aaactgcaaa
    17401 aatcatatca gaggatatga atcttcaccc cataatctat ccacaattac gtgaaataga
    17461 ttttggtgaa tgggaaggtt taactgtaaa agatataaaa aataattacc ctgaactatt
    17521 taagctctgg ctgatagatg atactacagg tcctctttgc ggcggagatg gcagcctaaa
    17581 gaaagccagt ataagagcca cagatgccat tttagaaatc gttaaagaaa acaagaataa
    17641 aaatattgca gtagttgctc atggaggtat cataaaggca gctttgatag gtatctttaa
    17701 ctggaatatg agtatgtatc acaaaattcg tctaggtaat acttctataa ccagattata
    17761 ctttgatgat aatatgaatc ctcttatatt gtgtttaaat gataccagtc atcttcctga
    17821 tgattataat ataaagtcat atgtttag
//
