LOCUS       NC_015687.1            10795 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  NC_015687.1 Clostridium acetobutylicum DSM 1731, complete sequence.
ACCESSION   NC_015687
VERSION     NC_015687.1
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 6.1.1
            Run date     :: 2024-03-14 15:30:49
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 2577250
            Orig. end    :: 2588045
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..10795
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[2582250:2583045](-)"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193)"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(5001..5795)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193)"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
     cand_cluster    1..10795
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193)"
                     /kind="single"
                     /product="RiPP-like"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..10795
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="RiPP-like"
                     /region_number="5"
                     /rules="(strepbact or Antimicrobial14 or Bacteriocin_IId or
                     BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or
                     Lactococcin or Antimicrobial17 or Lactococcin_972 or
                     Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or
                     TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or
                     TIGR03975 or DUF692 or TIGR01193)"
                     /tool="antismash"
     CDS             835..1380
                     /locus_tag="ctg1_2452"
                     /transl_table=11
                     /translation="MDEKSKKVLENYKDKKLSAEFGEEISDLRSQLSAMECTLNQLKSS
                     GSSVSGRQSFYGTQSQMSQQGQQGQQAQQSQQTATQLMSQIQNFRQQAQQQQQQTQQQL
                     QNSVKQAMDALNQVNQQIVSNEVFGKMNQIINQAQEQLNIMAMGEQQNKQNQGGSTSYM
                     QTNMQKNMQSTMQSGSMQ"
     CDS             complement(1488..2288)
                     /locus_tag="ctg1_2453"
                     /transl_table=11
                     /translation="MKKGKILSAILIALVAAVLGGCSVKSSAKDDKALSYLKKKYGMQF
                     VIDGYYNSNDGKEVERSKIITHPTNNKSKPFIVERVKIGTDTKITYEDDYSCRLIEPMV
                     DKKVKNILGNDSSNIKCASYVSAEDYQNLDDYTSKIDYDAFIKDQGNNSTINIIAVVNH
                     GDNFDKNTEAQKVYSFMKKIVDTKLVKTHMHIEVSFYFVKSQYYNKTNPQAIAYRYNRS
                     MMDSEWLNKNENTTKNYVDHSFTLRSEDGLSYNQDINEIMKNMH"
     CDS             complement(2312..3094)
                     /locus_tag="ctg1_2454"
                     /transl_table=11
                     /translation="MKKRRILSALLIVSIVAVLGGCVKPGVSKEQVQNYLKKKYKKEFV
                     VDGYYHSSKKVDRLKMIAHPKGNPEDKFLVEKYNYDTKSVYEDNYASRVYSHMVDDKIK
                     ATVGNDFPNFKYASYISLYECTKENYINPIDYDKFVEDQGKISTINISVIVNYGDDFNK
                     NTEAQQIYAFMKKIIDNKLVKSPMQVEASFYFVDSKNFAKANAKECAYNDSKSALGQDY
                     SKNDINIYSKYNIDHDCNLESEDGINYNQDIRDIINKL"
     CDS             complement(3115..3948)
                     /locus_tag="ctg1_2455"
                     /transl_table=11
                     /translation="MRKSILAIVLILLSLIGYSKGKVEEPPNISTKNRDVMLNYIEKKY
                     GKKFVFKDYYNIGEGKKDNSKAIFYPKEDKTKRFTVYKVKEVQDVKENGKDVIKTVNTY
                     EDDYALRLIEPIVDKKIKNSVGIGFPNFKYASYITTYGPTKGKYTNKVDYDEFVAKEGQ
                     VAHMNIVIFVNYEKSFDKHKEAEESYSFIKKVIDSKLIKSPMELEAKFYYLNERDYKKI
                     NARKNRYDFGDYMTGEHENTQSVNFKYRVQHFLDLKSKGGINYNQDVLDIENKIK"
     CDS             complement(4309..4728)
                     /locus_tag="ctg1_2456"
                     /transl_table=11
                     /translation="MKFNDEKVKEIVTPFMDEDDLASYYCYGIVTATRLQMFLLGSFSG
                     LANKQYLLTFTNKKLIMTRMGMSGKLKGSEVIEYTNIKSAKISNLFFVFGKKIKLKFND
                     GSKVKFNINRRVMGIKKQGENLQNICQILRGKFAA"
     PFAM_domain     complement(4333..4683)
                     /aSDomain="bPH_3"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF14470.8"
                     /description="Bacterial PH domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_2456_0115"
                     /evalue="5.10E-12"
                     /label="ctg1_2456"
                     /locus_tag="ctg1_2456"
                     /protein_end="132"
                     /protein_start="15"
                     /score="46.1"
                     /tool="antismash"
                     /translation="MDEDDLASYYCYGIVTATRLQMFLLGSFSGLANKQYLLTFTNKKL
                     IMTRMGMSGKLKGSEVIEYTNIKSAKISNLFFVFGKKIKLKFNDGSKVKFNINRRVMGI
                     KKQGENLQNICQI"
     CDS             complement(5001..5795)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: DUF692"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg1_2457"
                     /sec_met_domain="DUF692 (E-value: 4.4e-11, bitscore: 40.2,
                     seeds: 7, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MYIGCNWSKALKFLLEKDEVKIDYIKAGAYGDFENEFSTMRSMKP
                     ILIHGLGKFERTGMKDINLVDFDRANSIIKRCSSPHFGIHLEIKNSDMYEGMRDENIYE
                     YMCKQIQTFKKNIEVPLLLENVPDSPIEHTVFDCYPYFQPKKLTKLFLDNNVDFLLDLT
                     HAKITSKYHKIDVHEYLNGLPLERVREIHVNGSGYDEEGFPMDTHSSMEKEDYDLLRWV
                     LTYSKPYVVTLEYAGTKKEKEADIIASLKTQLREIQNIIISR"
     PFAM_domain     complement(5088..5708)
                     /aSDomain="DUF692"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF05114.15"
                     /description="Protein of unknown function (DUF692)"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_2457_0116"
                     /evalue="1.30E-17"
                     /label="ctg1_2457"
                     /locus_tag="ctg1_2457"
                     /protein_end="236"
                     /protein_start="29"
                     /score="64.0"
                     /tool="antismash"
                     /translation="YGDFENEFSTMRSMKPILIHGLGKFERTGMKDINLVDFDRANSII
                     KRCSSPHFGIHLEIKNSDMYEGMRDENIYEYMCKQIQTFKKNIEVPLLLENVPDSPIEH
                     TVFDCYPYFQPKKLTKLFLDNNVDFLLDLTHAKITSKYHKIDVHEYLNGLPLERVREIH
                     VNGSGYDEEGFPMDTHSSMEKEDYDLLRWVLTYSKPYVVTLEYA"
     CDS             5887..6285
                     /locus_tag="ctg1_2458"
                     /transl_table=11
                     /translation="MIFNSLVPELSVTNIVISKSFYVDILSFKVQYEREEDSFAFISLN
                     GAQLMLDEGANGSWSTALTTYPFGRGINLQFFVEDVEKIITSLNKHNIKLFKDPFISNY
                     RIGPENHTFKEVLVQDPDGYLLRFSQKI"
     CDS             complement(6454..6777)
                     /locus_tag="ctg1_2459"
                     /transl_table=11
                     /translation="VTNNEGYGTLLITNGINRVKLGEKTWIILNANSSTGYVWRLTLDN
                     SKVYRIDKNFYLPSRTGSVGTPGKAVWILKAIKKGEASIVLNYARVFDKEALKSIVYSI
                     IVE"
     PFAM_domain     complement(6490..6723)
                     /aSDomain="Inhibitor_I42"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF09394.12"
                     /description="Chagasin family peptidase inhibitor I42"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_2459_0117"
                     /evalue="2.30E-17"
                     /label="ctg1_2459"
                     /locus_tag="ctg1_2459"
                     /protein_end="96"
                     /protein_start="18"
                     /score="63.3"
                     /tool="antismash"
                     /translation="VKLGEKTWIILNANSSTGYVWRLTLDNSKVYRIDKNFYLPSRTGS
                     VGTPGKAVWILKAIKKGEASIVLNYARVFDKEA"
     CDS             complement(6796..7218)
                     /locus_tag="ctg1_2460"
                     /transl_table=11
                     /translation="LVIEKLRIEDIPQLLKLYNTLAPFESSHKKSLEVYNEMLKDENYL
                     LLAAKKEEEIIGSVLGICCKGLMFPFLVIEDVIVKEEIRGKGVGRKLMKALDEFANRKN
                     CSYAILVSSGFREGAHKFYERVGFKDSVRGFRKIYY"
     PFAM_domain     complement(6835..7152)
                     /aSDomain="Acetyltransf_1"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00583.27"
                     /description="Acetyltransferase (GNAT) family"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_2460_0118"
                     /evalue="3.70E-16"
                     /label="ctg1_2460"
                     /locus_tag="ctg1_2460"
                     /protein_end="128"
                     /protein_start="22"
                     /score="59.5"
                     /tool="antismash"
                     /translation="PFESSHKKSLEVYNEMLKDENYLLLAAKKEEEIIGSVLGICCKGL
                     MFPFLVIEDVIVKEEIRGKGVGRKLMKALDEFANRKNCSYAILVSSGFREGAHKFYERV
                     GF"
     CDS             complement(7398..7571)
                     /locus_tag="ctg1_2461"
                     /transl_table=11
                     /translation="MKDYDNFFLGVEDVKDTYEILKKRGVSFLSDPFKINTGTALEFED
                     TFGNRLGITDYK"
     CDS             complement(7573..7812)
                     /locus_tag="ctg1_2462"
                     /transl_table=11
                     /translation="MKTCIACGMPMNNKGDFAVGDESKDYCKYCAREDGTMQNYNEKLK
                     GMTEFIVRTQGFDVKAAENIAREMMSKLPAWREL"
     PFAM_domain     complement(7582..7806)
                     /aSDomain="Zn_ribbon_2"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF12674.9"
                     /description="Putative zinc ribbon domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_2462_0119"
                     /evalue="3.50E-17"
                     /label="ctg1_2462"
                     /locus_tag="ctg1_2462"
                     /protein_end="77"
                     /protein_start="2"
                     /score="62.9"
                     /tool="antismash"
                     /translation="TCIACGMPMNNKGDFAVGDESKDYCKYCAREDGTMQNYNEKLKGM
                     TEFIVRTQGFDVKAAENIAREMMSKLPAWR"
     CDS             complement(8018..8605)
                     /gene_functions="regulatory (smcogs) SMCOG1057:TetR family
                     transcriptional regulator (Score: 81.5; E-value: 1.8e-24)"
                     /gene_kind="regulatory"
                     /locus_tag="ctg1_2463"
                     /transl_table=11
                     /translation="MKVSQRQIQKQETRKKIIEAAYEKFKNKGIVKTTTSDIAKAAGVS
                     HGTIFAHFKTQEELLREVIQVFCSKIIMHTHSVSEKAVTMREVLSAHLEGIKEFEEFYI
                     RLVSEMNLLPKDSISVFVSIQSALSKHLTEVAEKEIDEGKIKRLPISFIFNTWIGLVNY
                     YLLNRELFAPGESVIDRYKNQLVDNFIELIKK"
     PFAM_domain     complement(8417..8557)
                     /aSDomain="TetR_N"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00440.25"
                     /description="Bacterial regulatory proteins, tetR family"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_2463_0120"
                     /evalue="3.40E-14"
                     /label="ctg1_2463"
                     /locus_tag="ctg1_2463"
                     /protein_end="63"
                     /protein_start="16"
                     /score="52.5"
                     /tool="antismash"
                     /translation="IIEAAYEKFKNKGIVKTTTSDIAKAAGVSHGTIFAHFKTQEELLR
                     EV"
     CDS             8756..9508
                     /locus_tag="ctg1_2464"
                     /transl_table=11
                     /translation="MIFKEFGNKNMPTIVFLHGGGLSFWSFKEELSALKNSYRIVTPII
                     DGHGEDYNNTFISISNSAKHVINYIQESCNGHVFCICGLSLGAQILVEVLSLKHNISEY
                     AVIESALVYPIKLSLNLMVAMNSLAYGLIKKKWFAKLQAKTLNVPQELFETYYKESSKM
                     TKETLINITKSNGSYPMPNSICNTTASTLILVGERELSIMKKSAKLLNETIDNSILNII
                     PKAKHGEISLAYPKQYLDLLNKLFNSKK"
     CDS             9572..9808
                     /locus_tag="ctg1_2465"
                     /transl_table=11
                     /translation="MKNRLKELREAFGLTQEQLGNLIGVSRQAINSIETEKCEPSIWLA
                     YDISKVFHKSIEYIFLFEESEKKSRAKQIRGVI"
     PFAM_domain     9584..9748
                     /aSDomain="HTH_3"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF01381.24"
                     /description="Helix-turn-helix"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_2465_0121"
                     /evalue="5.10E-12"
                     /label="ctg1_2465"
                     /locus_tag="ctg1_2465"
                     /protein_end="59"
                     /protein_start="4"
                     /score="45.7"
                     /tool="antismash"
                     /translation="LKELREAFGLTQEQLGNLIGVSRQAINSIETEKCEPSIWLAYDIS
                     KVFHKSIEYI"
     CDS             9809..10261
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1275:peptide deformylase (Score: 142.7; E-value:
                     1.2e-43)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg1_2466"
                     /transl_table=11
                     /translation="MALRQIRLSEDEILRKKSRPVEVVDDKIRQILDDMLDTLQNTENG
                     AAIAAPQVGILKQLVVIATGEDIIKLVNPKIVKKEGEQEVVEGCLSIPNVYGKLKRPKK
                     VTVEALNENGEKITLTGEGFLAKCFCHEIDHLDGILFTDLVTEYIK"
     PFAM_domain     9821..10246
                     /aSDomain="Pep_deformylase"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF01327.23"
                     /description="Polypeptide deformylase"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_2466_0122"
                     /evalue="1.20E-43"
                     /label="ctg1_2466"
                     /locus_tag="ctg1_2466"
                     /protein_end="146"
                     /protein_start="4"
                     /score="148.6"
                     /tool="antismash"
                     /translation="QIRLSEDEILRKKSRPVEVVDDKIRQILDDMLDTLQNTENGAAIA
                     APQVGILKQLVVIATGEDIIKLVNPKIVKKEGEQEVVEGCLSIPNVYGKLKRPKKVTVE
                     ALNENGEKITLTGEGFLAKCFCHEIDHLDGILFTDLVT"
     aSDomain        9836..10246
                     /aSDomain="TIGR00079"
                     /aSTool="tigrfam"
                     /description="pept_deformyl: peptide deformylase"
                     /detection="hmmscan"
                     /domain_id="TIGRFam_ctg1_2466_0031"
                     /evalue="6.00E-45"
                     /identifier="TIGR00079"
                     /label="ctg1_2466"
                     /locus_tag="ctg1_2466"
                     /protein_end="146"
                     /protein_start="9"
                     /score="150.7"
                     /tool="antismash"
                     /translation="EDEILRKKSRPVEVVDDKIRQILDDMLDTLQNTENGAAIAAPQVG
                     ILKQLVVIATGEDIIKLVNPKIVKKEGEQEVVEGCLSIPNVYGKLKRPKKVTVEALNEN
                     GEKITLTGEGFLAKCFCHEIDHLDGILFTDLVT"
ORIGIN
        1 ttttcttttg gctttatatc atacttaggt acaacttttt taaagccttc ctcaaaagca
       61 ttaaaattct tttgcgcaat atcctcttta aacctaacat taagaacatc aaaagcaaag
      121 gctaaatcct gattaaataa tttcaataaa gcacccaaag caacactacc atatacccta
      181 acattaccta ttttatgagc aatatctctt aaaggtagag cataaactct tttatcttca
      241 tatttaatag aattatcaca aattacaaat ccatctttct ttaactcatt tatatgaagt
      301 tcaatggtac ttagatcaag tgctattatt ccatcaattt cctttacatg ggtacgtatt
      361 tcttcatttc caaatctaat ttgaaaaaaa ttatgtcctc ctcttactcg tgacatgtaa
      421 tcctgtgttg taaatatctc aaaacctttt ttctttaaaa ttttttgaag tatagctgct
      481 aaagtttcca ttccctgtcc tgcagctcct ccaatcaaaa tattataaat cataattatc
      541 cctccttata tgtgaaaggt tattcatttt tttccaaata ttttttacat ttccataata
      601 gcactttatt ctaaaattat caatattaat tattaaataa tatttattat tatttatctt
      661 ttactccaca atattaaata tattataata attcatcgaa attccatata aattaaatct
      721 gcccaccttt tcaatttaat tgccctactg atttagaata agaagaatta taattgggat
      781 aatataatat tgaattataa aataaaaatc ataaatttta aggagtgata ttcgatggat
      841 gaaaagagca aaaaagtact agagaactat aaagataaga aactcagtgc agaatttggt
      901 gaagaaatat cagatcttag aagtcagctt agcgccatgg aatgtacatt aaatcagctt
      961 aaatctagcg gttccagtgt aagtggaaga caaagctttt acggtactca aagccaaatg
     1021 tctcaacaag gccaacaagg acaacaagct cagcaaagtc aacaaaccgc aacacaatta
     1081 atgtctcaaa ttcaaaactt tagacaacaa gctcagcagc agcagcagca aactcaacag
     1141 caattacaaa actctgttaa acaagcaatg gatgctttaa atcaggtaaa tcaacaaata
     1201 gtatctaatg aagtatttgg aaaaatgaat cagattatca accaagcaca ggaacaatta
     1261 aatataatgg ctatgggcga acaacaaaac aagcaaaatc aaggtggttc tacaagctat
     1321 atgcaaacca atatgcagaa aaatatgcaa agcactatgc aaagtggcag catgcagtaa
     1381 aaaacaaagt ggacctgagt ttaatcaagt ccactttatt taactattta aataggctgt
     1441 agtatattca atatatgtac tactcttaac attatattcc ttttaaatta atgcatattc
     1501 ttcataattt catttatatc ttggttataa ctaagtccat cttctgatct caaagtaaac
     1561 gaatgatcta catagttttt agttgtattc tcatttttat ttaaccattc agagtccatc
     1621 attgatctat tatatctata agcaattgct tgagggtttg ttttattata atactgagat
     1681 tttacaaaat aaaatgaaac ctctatatgc atatgtgtct ttactaattt agtatcaact
     1741 atctttttca taaatgaata tactttttga gcttcagtat ttttatcaaa attatctcca
     1801 tgattcacaa ctgctataat atttatagtt gaattattgc cttgatcctt aataaacgca
     1861 tcatagtcaa tcttacttgt ataatcatct aagttttgat agtcctctgc cgaaacatat
     1921 gacgcacact taatgtttga agaatcatta cctaatatat tctttacttt tttatctacc
     1981 ataggttcta ttaatctaca cgaatagtca tcctcataag tgatttttgt atcagttcct
     2041 atcttaaccc tttcaactat aaatggcttg cttttattat ttgtcggatg agttattatt
     2101 ttagaacgct ctacttcttt tccatcatta gaattatagt atccatcaat tacaaattgc
     2161 attccatatt ttttctttaa ataacttaaa gccttgtcat ccttagctga tgatttaaca
     2221 ctgcatccac ctaaaaccgc tgcaaccaat gctattaata tggcacttag tatttttccc
     2281 ttcttcattt attctcctcc tattttacca atcaaagttt atttataata tctcttatgt
     2341 cctgattgta gttaattcca tcttctgatt ctaggttgca atcatgatct atattatact
     2401 tagagtagat attgatatca ttctttgaat aatcctgtcc aagggcactt ttagagtcat
     2461 tgtacgcaca ttcttttgca tttgctttag caaaattctt ggaatctaca aaatagaaag
     2521 aggcttctac ttgcattggg cttttcacca acttattatc aattattttt ttcatgaatg
     2581 catatatttg ctgtgcttct gtattcttat taaagtcgtc accataattt acaataacac
     2641 ttatattaat tgttgaaatt ttaccttgat cctccacaaa tttatcataa tcaattgggt
     2701 ttatataatt ctcttttgtg cattcataaa gcgatatgta cgaagcatat ttaaagtttg
     2761 gaaaatcatt tcctactgta gcttttatct tatcatctac catgtgagaa tatactctag
     2821 atgcataatt atcttcatat acgcttttag tatcataatt atatttttct actaaaaatt
     2881 tatcctctgg atttcccttt ggatgtgcta tcatttttaa tctgtctact tttttactac
     2941 tatggtaata tccatctact acaaattcct ttttatattt cttttttaaa tagttttgaa
     3001 cctgctcttt acttacccct ggtttaacac atccacctaa aactgctaca attgatacta
     3061 ttaataaagc acttaatatt cttctttttt tcatttctct tgctcctaaa tttattattt
     3121 aattttattt tcaatatcta gtacatcctg attataatta attccacctt tagactttaa
     3181 atcaagaaaa tgttgtactc tatacttaaa attcacactt tgagtattct catgttcacc
     3241 cgtcatatag tcaccaaaat cgtatctatt ttttcttgca tttatctttt tatagtctct
     3301 ttcatttaaa tagtaaaact tagcttctaa ctccattgga ctttttatca acttactgtc
     3361 aattactttt tttataaatg aatagctttc ctctgcttcc ttgtgcttat caaagctttt
     3421 ttcatagttt acaaaaatca cgatattcat atgagctact tgtccttctt ttgctacaaa
     3481 ctcatcataa tctactttat ttgtgtattt gccttttgtt ggtccatagg ttgtaatgta
     3541 cgaagcatat ttaaaatttg gaaatcctat tcctactgaa ttttttatct ttttatctac
     3601 tataggttca attaatctaa gggcataatc atcttcatag gtgtttacag ttttgataac
     3661 atccttacca ttttccttta catcctgaac ctctttaact ttatatactg taaatctctt
     3721 tgttttgtct tcttttggat aaaatatagc ttttgaatta tccttttttc cttctccaat
     3781 attgtaataa tctttaaata caaacttttt cccatacttt ttttcaatgt aatttagcat
     3841 tacatctcta ttttttgtgc ttatattagg aggctcttca acttttcctt tactgtatcc
     3901 aataagtgat agcaaaatta atactattgc taatatactc tttctcatat attatctcct
     3961 agttccttaa aaaattattt tgactatcct taacgtaatt atctttgaat tttataattt
     4021 aattaatcac tataaatttt catttaaatt caacttaatt gtataaaatc agctaacttt
     4081 aactaaataa actttatgtg attaagaaat atttttttac cacgaaggat ataatatcac
     4141 atttttagtt atttttccat cttttttaaa caatttttat ataggattaa agtttttgct
     4201 aaatttagaa ttaggatatt tttttcaacg ttgtacttta taaatctata ataataaaag
     4261 aatgttcaat aaattttctt atcaaacatc cctttaatct ataattattt atgcagcaaa
     4321 ttttccccta agtatttggc aaatgttttg tagattttcg ccctgttttt ttattcccat
     4381 aacacgacga tttatgttaa attttacttt tgaaccatca ttaaatttta atttaatttt
     4441 ctttccaaac acaaaaaaca aatttgatat ttttgcactc tttatatttg tatactctat
     4501 aacttctgat ccttttaact ttccagacat acccattcta gtcattatta attttttgtt
     4561 agtaaatgtt aataaatatt gcttattagc caatcctgaa aaacttccta aaagaaacat
     4621 ttgaagtcta gttgctgtta caatgccgta acaataatat gaagctaaat catcttcgtc
     4681 cataaatggt gtaactattt cttttacttt ttcatcatta aatttcataa taaatcctcc
     4741 aaaccttgct aaattccatt taacatatta tcataattta attaaaaaat ctcttataaa
     4801 cttttaaaaa attttctttt ttaagattat gatgtaatat aaggtttgaa tttggccaaa
     4861 aactttttaa atttctctta aatctttcca ctttaggttc taaacgggta gaccggtaaa
     4921 cccttcaatc aaagcttata tgtctttact ataggatttt tttgcataaa attaagcaag
     4981 tatttttcac acctgcctac ctatctactt ataataatat tttgtatttc tctaagctgc
     5041 gtttttaaag aagctataat atcagcctct ttttctttct ttgtaccggc atactctaag
     5101 gtaaccacgt aaggctttga atatgttaaa acccatctaa gaagatcata atcctctttt
     5161 tccatagaac tatgcgtatc cataggaaat ccttcttcat catatcctga accattaaca
     5221 tgaatttctc taacacgttc aagtggaagt ccatttagat attcgtgaac atctatttta
     5281 tgatatttcg aagttatttt ggcatgagtt aaatcaagta aaaaatcaac attattatct
     5341 aaaaataatt ttgtaagttt tttaggctga aaatatggat aacaatcaaa tacggtatgt
     5401 tctattgggg aatctggaac attttctagc aaaagaggaa cttctatatt tttcttgaaa
     5461 gtctgaattt gcttacacat atattcatat atattctcat ctctcattcc ttcgtacata
     5521 tccgaatttt ttatttcaag atgtattcca aaatgaggag aactgcacct tttaataata
     5581 gaatttgcac gatcaaaatc aactaagtta atatccttca tacctgtgcg ttcaaatttt
     5641 cccagcccat gtataagaat tggtttcatt gagcgcatag tagaaaattc attttcaaaa
     5701 tctccatacg cacctgcttt aatataatct atcttaacct catctttttc tagaagaaat
     5761 ttcaaagcct ttgaccaatt acatccaata tacataacta tatctccctt tttcaataat
     5821 atatactttt tccttttata ttatggtaaa ctataaatta ttatagcata tagtgaaggt
     5881 aatcctatga tttttaatag cctggtacct gagttatctg taactaacat agtcatatca
     5941 aaaagctttt atgttgatat actctccttt aaagtccaat atgaaagaga agaagatagt
     6001 tttgccttca tttcacttaa tggtgctcaa ctaatgcttg atgaaggtgc taatggaagc
     6061 tggagtacag ctttgactac ttatcctttc ggaagaggaa ttaaccttca attttttgta
     6121 gaagatgtag aaaaaattat aacttcttta aataaacaca atataaagct atttaaagat
     6181 ccatttatta gcaattacag aataggtcct gaaaatcata ctttcaagga agttttagtt
     6241 caagatcctg atggatatct cttaagattc tcacaaaaaa tttaaaataa attaaatact
     6301 atcttattat tttaaatttc attgaactat aaacttttgc ctttgcccaa ttttgtacat
     6361 ttcattttaa gctggaaggc ttgctatttc tttaagattt aatttaagct tcttacagag
     6421 gttattataa acatatccac tctctaaatt aagttactcc actattattg aatacacaat
     6481 actttttaaa gcttctttat caaagactct agcgtaattt aaaactatag aagcttcccc
     6541 ttttttaatt gcctttaaaa tccatactgc tttccctgga gttcctaccg atcctgttct
     6601 agatggcaaa taaaagttct tatcaattct atatactttg gaattatcta aagttaacct
     6661 ccatacatac ccagttgatg aatttgcatt caatataatc caagtttttt ctccaagctt
     6721 aactctatta atgccgtttg taatgagtaa tgttccatac ccttcattat ttgtcacatt
     6781 tttgcctcct tatatttagt aataaatttt acgaaaacct ctaacactat ctttaaatcc
     6841 aaccctctca taaaatttat gtgcaccttc tctaaatcca gaggatacaa gaattgcata
     6901 cgaacagttt tttctatttg caaattcatc aagagctttc atcaactttc ttccaactcc
     6961 ttttcctcta atttcctctt ttacaattac gtcctcaatc accaaaaatg ggaacattaa
     7021 tcctttgcag catattccaa gtactgatcc tatgatttct tcttcttttt ttgctgctaa
     7081 caagagataa ttttcgtcct ttaacatctc attatatact tcaagtgatt ttttgtgaga
     7141 actttcaaat ggggcaagtg tattataaag ctttaaaagt tgtggaatat cttctatcct
     7201 taatttttct atgaccaaag ttaaaacctc ctttccacct taataattta tcaactagag
     7261 tgaaatcatt tatttccgaa agcaatacat atattatact tcaattgaaa atttttacaa
     7321 aacaattcat ataaaaaatg ttgatattat atattaaacg gattaataac atacaatatc
     7381 aacattttag tttattctta tttgtaatca gtaattccta atctattccc aaaagtatct
     7441 tcaaattcca aagccgtccc tgtatttatt ttaaagggat ctgataaaaa gcttactcct
     7501 ctcttcttaa gtatttcata tgtatcctta acatcttcaa cacctagaaa aaagttatca
     7561 taatccttca ttttaaagct ccctccaagc aggaagctta gacatcattt ccctagcgat
     7621 attttctgca gctttaacat caaatccttg agttctaact ataaattcag tcattccctt
     7681 aagtttttca ttataatttt gcattgttcc atcttctcta gcacagtatt tacagtaatc
     7741 tttactttca tcacctactg caaaatctcc tttgttattc attggcatgc cacaagctat
     7801 acaagttttc ataatttatc ccctttcatt cattgactaa ttactcattg actatatgct
     7861 cattataatt ttaatatttt cctttgtcaa taaaaacgag tgtattttaa aattaattga
     7921 taatccaata acaaaaataa tagaaactat aaaaatttct atatgtaaat taaaacagcc
     7981 cttagttaat tagctatggg ctgtaaattt caatatacta tttttttatt aactctataa
     8041 aattatctac taattgattt ttatatctat ctataacaga ttctcctggt gcaaataatt
     8101 ctctatttaa taaataataa tttacaagtc ctatccaagt attaaaaata aagcttatag
     8161 gcagcctttt tatctttccc tcatctattt ctttttcagc tacttcagtt aaatgctttg
     8221 aaagtgcaga ttgaatagac acaaaaacac ttattgaatc ctttggcaga agattcatct
     8281 cactcacaag ccttatataa aattcttcaa attcttttat tccttcaagg tgagcactta
     8341 aaacttctct catagttaca gccttctctg aaacactatg cgtatgcata attattttac
     8401 tacagaacac ctggattacc tctcttaaaa gctcctcctg tgttttaaaa tgagcaaaaa
     8461 ttgtgccgtg agacacacct gcagcttttg ctatatctga ggttgtagtt tttacaattc
     8521 ctttgttttt aaatttctca tacgcagcct ctattatctt ttttctagtt tcttgttttt
     8581 gaatttgtct ctgtgatacc ttcatttcac cgtctccata ctcactgatt ttatgctcat
     8641 tatattttat agatatatat atgtcaataa tccattcttc acactatata gaactcagat
     8701 ttcatttaat aagtgctata atatatatat cttttatcgg ggggtatact ttcttatgat
     8761 tttcaaggaa tttggtaata aaaatatgcc tactatagtt tttcttcatg gtggaggcct
     8821 ttccttctgg tcctttaaag aagaactatc tgcattaaaa aatagctata gaattgttac
     8881 acctattatt gatggtcacg gagaagacta taataacact tttataagta taagtaactc
     8941 tgctaaacat gttatcaact atattcaaga gagctgtaat ggacatgtct tttgtatttg
     9001 tggtctttct ctcggtgctc agattcttgt tgaagtatta tctttaaagc ataatatttc
     9061 agaatatgct gttatagaaa gtgcattagt ttatcctata aaattatcac ttaatttaat
     9121 ggttgcaatg aacagcctag cctatggact tataaaaaag aagtggtttg caaagcttca
     9181 ggctaaaacc ttaaatgtac ctcaagaatt atttgaaacc tactataaag aaagttcaaa
     9241 gatgacaaaa gaaacattaa taaatattac aaaaagcaat ggatcttatc caatgcctaa
     9301 ttctatatgt aacacaacgg caagtacact tatattagta ggagaaaggg aactatctat
     9361 aatgaaaaag tctgctaaac ttctcaatga aaccatagat aacagcatat taaacattat
     9421 accaaaagct aagcatggcg aaataagttt agcttatcca aaacagtatt tagacttatt
     9481 gaataagctt tttaatagca aaaagtaagg tatacttgac acaaaaaaat acatatgcta
     9541 tattgtgtgt aagatataga ggtgatgatt tatgaaaaac agattaaaag aacttagaga
     9601 agcctttggc ttaactcaag aacagcttgg aaatcttata ggtgtatcta gacaagccat
     9661 taactccata gaaacagaaa agtgtgaacc ttctatatgg ctagcttatg atatttctaa
     9721 ggtttttcat aaatctatag aatatatttt tctttttgaa gaaagtgaaa aaaaatcaag
     9781 agctaaacaa atcagaggtg ttatataaat ggcgttgaga caaattagac tttcagagga
     9841 tgaaatatta agaaaaaaga gcagacctgt tgaggtagtt gatgataaga taagacaaat
     9901 tttagatgac atgctggata cccttcaaaa cacagaaaac ggtgctgcca tagctgctcc
     9961 acaggtagga atattaaaac aactagttgt aatagctaca ggagaagata tcataaagct
    10021 tgttaatcct aaaatagtaa aaaaagaagg agaacaagaa gttgtagagg gctgcttaag
    10081 tattccaaat gtatatggaa aacttaaaag acctaaaaaa gtaacagttg aggctttaaa
    10141 cgaaaatggt gaaaaaatca ctttaacagg agagggtttt ctagcaaaat gtttttgtca
    10201 tgagatagat catttagatg gaattctttt tacagactta gtaactgaat atataaaata
    10261 atccccaagg accgcataat tcaatcaaat tatgcggttt ttctatatat gttttattta
    10321 attaatagta gtgctataat tattatataa atttccttta ttttcaacac ttaatacata
    10381 cctgaaaaat aaacattaat tccaaggggg aataaccatg tttaaggaaa tgagacgaaa
    10441 agaaagagag cttagtttta aggaaactga aaaaatacta aaaagctgtg aatatggtgt
    10501 tttatctacc ataggtgaaa atgggtatcc ctatggtgta ccaataagct acgtatattt
    10561 aaatggcttt atttattttc acagtgccac agaaggacat aaactagaaa atatagaaaa
    10621 taaccccaag ctatgctttt ctattgttgg aaaaacctct gtactgcctg ataagtttac
    10681 tacaaactat gaaagtgtag ttgtatttgg aactgccgaa gaagtcttta atgaagagaa
    10741 aaacgaggtt cttttggaga tattaaaaaa atactcctct tcttacatag aaaaa
//
