LOCUS       c00091_NZ_CBVI..        9070 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  NZ_CBVI010000091.1 Bacteroides timonensis isolate AP1, whole genome
            shotgun sequence.
ACCESSION   NZ_CBVI010000091
VERSION     NZ_CBVI010000091
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 6.1.1
            Run date     :: 2024-03-14 15:53:01
            Original ID  :: NZ_CBVI010000091.1
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 9070
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..9070
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="True"
                     /core_location="[1904:4070](+)"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193)"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      1905..4070
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193)"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
     cand_cluster    1..9070
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193)"
                     /kind="single"
                     /product="RiPP-like"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..9070
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="RiPP-like"
                     /region_number="1"
                     /rules="(strepbact or Antimicrobial14 or Bacteriocin_IId or
                     BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or
                     Lactococcin or Antimicrobial17 or Lactococcin_972 or
                     Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or
                     TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or
                     TIGR03975 or DUF692 or TIGR01193)"
                     /tool="antismash"
     CDS             complement(275..748)
                     /locus_tag="ctg91_1"
                     /transl_table=11
                     /translation="MWFFWNAGRLPEDWTTQKLFEKHPSRPYNPSIANALFRCGDIESW
                     GRGYKRILEAVGSYNLLPPVVQVLSGLMITYYTDVHSQLVSQNLDKRFMPVIEYAAKNG
                     AVTNSDVQRLLNTSKATAYRILSQLDNWLEIQGTTGKGTHYTLKGFTKDSKSE"
     PFAM_domain     complement(548..736)
                     /aSDomain="HATPase_c_4"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF13749.8"
                     /description="Putative ATP-dependent DNA helicase recG
                     C-terminal"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg91_1_0001"
                     /evalue="3.10E-09"
                     /label="ctg91_1"
                     /locus_tag="ctg91_1"
                     /protein_end="67"
                     /protein_start="4"
                     /score="36.9"
                     /tool="antismash"
                     /translation="WNAGRLPEDWTTQKLFEKHPSRPYNPSIANALFRCGDIESWGRGY
                     KRILEAVGSYNLLPPVVQ"
     CDS             complement(714..1616)
                     /locus_tag="ctg91_2"
                     /transl_table=11
                     /translation="MSENQNIEWKESWRDEYLKWICGFANAVGGKIYIGMDDNGKVVGA
                     PNAKKLLEDIPNKVRDVLGVIVDVNLLEENGLEYIEIVVPPYSNPINYKGQYHYRTGST
                     KQELKGGALNRFILQRTGKNWDDFLIAGVTIEDLSTNALRRFRREAAKSNRVDADILND
                     TTEHLLYDLRLIDDDTRQLTRAAVLLFHPDPEKYVRGAYIKIGFFRNDNEDLAFQDEVH
                     GSLMEQIDKAMDLIKTKYLIYSISYEGGARRETPQFPVEALRESLMNCIAHKSYEDATP
                     TQISVYPDHVVFLECRAFA"
     PFAM_domain     complement(1293..1610)
                     /aSDomain="AlbA_2"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF04326.16"
                     /description="Putative DNA-binding domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg91_2_0002"
                     /evalue="2.20E-12"
                     /label="ctg91_2"
                     /locus_tag="ctg91_2"
                     /protein_end="108"
                     /protein_start="2"
                     /score="47.4"
                     /tool="antismash"
                     /translation="ENQNIEWKESWRDEYLKWICGFANAVGGKIYIGMDDNGKVVGAPN
                     AKKLLEDIPNKVRDVLGVIVDVNLLEENGLEYIEIVVPPYSNPINYKGQYHYRTGSTKQ
                     EL"
     CDS             1905..4070
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: TIGR01193"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_C39"
                     /gene_functions="resistance (resist) ABC_efflux (Score:
                     249.1; E-value: 5.4e-76)"
                     /gene_functions="transport (smcogs) SMCOG1288:ABC
                     transporter related protein (Score: 332.8; E-value:
                     6.5e-101)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg91_3"
                     /sec_met_domain="TIGR01193 (E-value: 1.3e-160, bitscore:
                     529.0, seeds: 5, tool: rule-based-clusters)"
                     /sec_met_domain="Peptidase_C39 (E-value: 1e-34, bitscore:
                     112.2, seeds: 36, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKKGTKIKQHDITDCGAACLASVCAHYGLRFPVSRIRQYAFTDQK
                     GTNVLGLIEAANKLGLSAKGVRAQFDALYTIPKPTIAHVLVNHKQLQHFVVIYKVTKTH
                     ITYMDPGDGRMHKVLHEDFRHDWTGILVLMEPEETFKKGNQQTSMSKKFLSLLAPHKSV
                     MLQAVFGALVFSILGLSTSIYVGKITDYVLVDKNTNLLNLMGVIMLIILLLRTFIGAMK
                     SILALKTGQRIDAALILGYYKHLLTLPQQFFDTMRVGEIISRVNDAVKIRNFINNVSLD
                     LVVNIMILVFSLCLMFIYSWKLAVMTLISAPLFLLIFWGFNKLNRKYQRSIMESSADLE
                     SQLVESINSISTIKRFGIEEYANLKTESRFVHLLKNTYRSIYGSILAQGGIQFVSTGIT
                     IAILWLGSILVIDQEMTPGTLMVFYSLVGYVISPIGSLISSNQTIQDALIAADRLFQIM
                     DLEREQDNEQKIILEPDMMGDIIFENVSFRYGSRKEVFNSLNLTIEKGKTTAVIGESGS
                     GKTTLISLLQHIYPIQSGRIRIGDYDIAQIDNRSLRRRVGTVPQQIELFAGTVTENIAL
                     GDTQPDMKRISSLVKQLGLTDFIDRLPNGYMTQVGEHGATLSGGERQRLAIARALYKEP
                     EILIFDEATSSLDSIAERYVKETLDALAGKGKTVIIIAHRLTTVRCADNIVVIDKGKVA
                     ETGTHSQLYDAGGSYFRLWNEQFAMLE"
     PFAM_domain     1923..2318
                     /aSDomain="Peptidase_C39"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF03412.17"
                     /description="Peptidase C39 family"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg91_3_0003"
                     /evalue="1.60E-32"
                     /label="ctg91_3"
                     /locus_tag="ctg91_3"
                     /protein_end="138"
                     /protein_start="6"
                     /score="112.2"
                     /tool="antismash"
                     /translation="IKQHDITDCGAACLASVCAHYGLRFPVSRIRQYAFTDQKGTNVLG
                     LIEAANKLGLSAKGVRAQFDALYTIPKPTIAHVLVNHKQLQHFVVIYKVTKTHITYMDP
                     GDGRMHKVLHEDFRHDWTGILVLMEPEE"
     aSDomain        1929..4046
                     /aSDomain="TIGR01193"
                     /aSTool="tigrfam"
                     /description="bacteriocin_ABC: ABC-type bacteriocin
                     transporter"
                     /detection="hmmscan"
                     /domain_id="TIGRFam_ctg91_3_0001"
                     /evalue="4.80E-159"
                     /identifier="TIGR01193"
                     /label="ctg91_3"
                     /locus_tag="ctg91_3"
                     /protein_end="714"
                     /protein_start="8"
                     /score="529.0"
                     /tool="antismash"
                     /translation="QHDITDCGAACLASVCAHYGLRFPVSRIRQYAFTDQKGTNVLGLI
                     EAANKLGLSAKGVRAQFDALYTIPKPTIAHVLVNHKQLQHFVVIYKVTKTHITYMDPGD
                     GRMHKVLHEDFRHDWTGILVLMEPEETFKKGNQQTSMSKKFLSLLAPHKSVMLQAVFGA
                     LVFSILGLSTSIYVGKITDYVLVDKNTNLLNLMGVIMLIILLLRTFIGAMKSILALKTG
                     QRIDAALILGYYKHLLTLPQQFFDTMRVGEIISRVNDAVKIRNFINNVSLDLVVNIMIL
                     VFSLCLMFIYSWKLAVMTLISAPLFLLIFWGFNKLNRKYQRSIMESSADLESQLVESIN
                     SISTIKRFGIEEYANLKTESRFVHLLKNTYRSIYGSILAQGGIQFVSTGITIAILWLGS
                     ILVIDQEMTPGTLMVFYSLVGYVISPIGSLISSNQTIQDALIAADRLFQIMDLEREQDN
                     EQKIILEPDMMGDIIFENVSFRYGSRKEVFNSLNLTIEKGKTTAVIGESGSGKTTLISL
                     LQHIYPIQSGRIRIGDYDIAQIDNRSLRRRVGTVPQQIELFAGTVTENIALGDTQPDMK
                     RISSLVKQLGLTDFIDRLPNGYMTQVGEHGATLSGGERQRLAIARALYKEPEILIFDEA
                     TSSLDSIAERYVKETLDALAGKGKTVIIIAHRLTTVRCADNIVVIDKGKVAETGTHSQL
                     YDAGGSYFRLWN"
     PFAM_domain     2403..3203
                     /aSDomain="ABC_membrane"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00664.25"
                     /description="ABC transporter transmembrane region"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg91_3_0004"
                     /evalue="5.30E-48"
                     /label="ctg91_3"
                     /locus_tag="ctg91_3"
                     /protein_end="433"
                     /protein_start="166"
                     /score="164.1"
                     /tool="antismash"
                     /translation="AVFGALVFSILGLSTSIYVGKITDYVLVDKNTNLLNLMGVIMLII
                     LLLRTFIGAMKSILALKTGQRIDAALILGYYKHLLTLPQQFFDTMRVGEIISRVNDAVK
                     IRNFINNVSLDLVVNIMILVFSLCLMFIYSWKLAVMTLISAPLFLLIFWGFNKLNRKYQ
                     RSIMESSADLESQLVESINSISTIKRFGIEEYANLKTESRFVHLLKNTYRSIYGSILAQ
                     GGIQFVSTGITIAILWLGSILVIDQEMTPGTLMVFYSLVGYVISP"
     PFAM_domain     3393..3839
                     /aSDomain="ABC_tran"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00005.29"
                     /description="ABC transporter"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg91_3_0005"
                     /evalue="3.90E-32"
                     /label="ctg91_3"
                     /locus_tag="ctg91_3"
                     /protein_end="645"
                     /protein_start="496"
                     /score="111.7"
                     /tool="antismash"
                     /translation="NSLNLTIEKGKTTAVIGESGSGKTTLISLLQHIYPIQSGRIRIGD
                     YDIAQIDNRSLRRRVGTVPQQIELFAGTVTENIALGDTQPDMKRISSLVKQLGLTDFID
                     RLPNGYMTQVGEHGATLSGGERQRLAIARALYKEPEILIFDEATS"
     CDS             4193..5509
                     /gene_functions="transport (smcogs) SMCOG1076:RND efflux
                     system, outer membrane lipoprotein, (Score: 166.8; E-value:
                     1.1e-50)"
                     /gene_kind="transport"
                     /locus_tag="ctg91_4"
                     /transl_table=11
                     /translation="MISVAITTFAFIGNVQAQNRRWSLQECIDHAIRHNIEVKQSRNRI
                     EKLKVEKSTLKNSFLPDLSAGTSQKFDFGRSLNRSNAYEDSNTQSSSFSVSAEMPLFTG
                     FRRSASVSRNKFDLMAAEADKELIENDLSLNVTSCYFQILLNKEIHKIAREQIRLTREQ
                     EDRTLLLIENGKAPQSQLYDVKAQLADDELTATEAKNSLRLSLLDLIQLMELQGHEEFD
                     IDSLDENISRTDTIMPQNIYAAALNCMPQIKQAYYSLQSSSKAIKVAKAGYYPTLSLGA
                     GISTGYYHSGNSINPSFRQQLQNNMQKSVYLSLSIPLFDRFSTRNEVRTARIEESNARL
                     SLENEKKNLYKEIEKAYTDAVNALEKYESTSKAVVANEEAHRYALEKYASGKSAVYEYN
                     EIKMKLAEALSKQSQAKYAYLLKERVLAFYSCRESALSH"
     PFAM_domain     4262..4831
                     /aSDomain="OEP"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF02321.20"
                     /description="Outer membrane efflux protein"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg91_4_0006"
                     /evalue="1.40E-33"
                     /label="ctg91_4"
                     /locus_tag="ctg91_4"
                     /protein_end="213"
                     /protein_start="23"
                     /score="116.4"
                     /tool="antismash"
                     /translation="LQECIDHAIRHNIEVKQSRNRIEKLKVEKSTLKNSFLPDLSAGTS
                     QKFDFGRSLNRSNAYEDSNTQSSSFSVSAEMPLFTGFRRSASVSRNKFDLMAAEADKEL
                     IENDLSLNVTSCYFQILLNKEIHKIAREQIRLTREQEDRTLLLIENGKAPQSQLYDVKA
                     QLADDELTATEAKNSLRLSLLDLIQLM"
     PFAM_domain     4907..5455
                     /aSDomain="OEP"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF02321.20"
                     /description="Outer membrane efflux protein"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg91_4_0007"
                     /evalue="5.60E-24"
                     /label="ctg91_4"
                     /locus_tag="ctg91_4"
                     /protein_end="421"
                     /protein_start="238"
                     /score="85.1"
                     /tool="antismash"
                     /translation="QNIYAAALNCMPQIKQAYYSLQSSSKAIKVAKAGYYPTLSLGAGI
                     STGYYHSGNSINPSFRQQLQNNMQKSVYLSLSIPLFDRFSTRNEVRTARIEESNARLSL
                     ENEKKNLYKEIEKAYTDAVNALEKYESTSKAVVANEEAHRYALEKYASGKSAVYEYNEI
                     KMKLAEALSKQSQAKYAYLL"
     CDS             complement(5886..6788)
                     /locus_tag="ctg91_5"
                     /transl_table=11
                     /translation="MRRFSYFLFLLLLVAAIDGFAQGVIKTEYMPASSFRDEAGNKLGS
                     GDLLKFTGAYTLPFSLKQNASGQPVMWSASVRGTYAMLNNRQMALDIHPDEVLSGSLNL
                     THVRPLSKKWYMIASLGAGIYSAPDAITWQSVLVNGGVIFVYKCRKNLDIGVGAGLTNS
                     FGVPIAMPMFFLNWQLSGNYEVNVNLSSGVEVSGAVRLGDRFKLRLVAMEMDGISSVMD
                     VEGKSMIYASVMMRSYLCPEYKIGKKSCLYLGIGGNWLRSGDLTKRTLKGFVDNMFSDK
                     DDPYFNPTVYFSAGVKCGF"
     PFAM_domain     complement(5895..6734)
                     /aSDomain="DUF6268"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF19783.1"
                     /description="Domain of unknown function (DUF6268)"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg91_5_0008"
                     /evalue="4.20E-88"
                     /label="ctg91_5"
                     /locus_tag="ctg91_5"
                     /protein_end="298"
                     /protein_start="18"
                     /score="295.0"
                     /tool="antismash"
                     /translation="GFAQGVIKTEYMPASSFRDEAGNKLGSGDLLKFTGAYTLPFSLKQ
                     NASGQPVMWSASVRGTYAMLNNRQMALDIHPDEVLSGSLNLTHVRPLSKKWYMIASLGA
                     GIYSAPDAITWQSVLVNGGVIFVYKCRKNLDIGVGAGLTNSFGVPIAMPMFFLNWQLSG
                     NYEVNVNLSSGVEVSGAVRLGDRFKLRLVAMEMDGISSVMDVEGKSMIYASVMMRSYLC
                     PEYKIGKKSCLYLGIGGNWLRSGDLTKRTLKGFVDNMFSDKDDPYFNPTVYFSAGVKC"
     CDS             complement(6922..7926)
                     /locus_tag="ctg91_6"
                     /transl_table=11
                     /translation="MKNKWYILLFIVIIAISLFAFQYVAELLSDAPRSLSLETQYLLNL
                     PACIFVGIVDFLIIVIVHKKLDNINNTMRIFIDLLLASVWVSCFGIAANYILSIILEEP
                     WPEDYALLKMSLPVVLWNSMIVLLIEIFFYQQSQMEAEKKLAIIEKEKIQYQYETLKAQ
                     INPHFLFNSLNVLSSLAYSDAEKTNLFAKKLSGVYRYLLLTNNRPMVTLKEELAFLESY
                     VFLEKIRFEDTLFIEIDEYDLYGTRLIIPVSLQLLVENAIKHNIATLKNPLIVRIGFTD
                     EGIMVSNNLQLRSSVDRGGVGLGNLEKQYALYDKVIDIVKSTTEFVVRVPFLE"
     PFAM_domain     complement(7228..7461)
                     /aSDomain="His_kinase"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF06580.15"
                     /description="Histidine kinase"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg91_6_0009"
                     /evalue="5.50E-24"
                     /label="ctg91_6"
                     /locus_tag="ctg91_6"
                     /protein_end="233"
                     /protein_start="155"
                     /score="84.4"
                     /tool="antismash"
                     /translation="QYETLKAQINPHFLFNSLNVLSSLAYSDAEKTNLFAKKLSGVYRY
                     LLLTNNRPMVTLKEELAFLESYVFLEKIRFEDT"
     CDS             complement(7940..8698)
                     /gene_functions="regulatory (smcogs) SMCOG1008:response
                     regulator (Score: 56.2; E-value: 6.2e-17)"
                     /gene_kind="regulatory"
                     /locus_tag="ctg91_7"
                     /transl_table=11
                     /translation="MMKYLLVEDERFAYEEMKRMMEKLRPDYQLEAWTATVEQTVQFLK
                     HHPVDLVLLDIRLTDGYSFDIFEQMQVTTPVIFTTAYDEHAIQAFKVNSVDYLLKPVEE
                     DDLLAALRKFEQFRVVQPPATDYRKLEEALMSNCKKNRFLIQKGDAYHYVETSDIAFFY
                     SEEKVVFLHTFSDKRYIVDYTLEQIEQLLDERTFFRVSRNCIANINSIRKISKYFNSRL
                     KLSFQPECPHEVLISRVRVPDFLKWVDGVL"
     PFAM_domain     complement(7958..8248)
                     /aSDomain="LytTR"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF04397.17"
                     /description="LytTr DNA-binding domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg91_7_0011"
                     /evalue="1.00E-21"
                     /label="ctg91_7"
                     /locus_tag="ctg91_7"
                     /protein_end="247"
                     /protein_start="150"
                     /score="77.1"
                     /tool="antismash"
                     /translation="YHYVETSDIAFFYSEEKVVFLHTFSDKRYIVDYTLEQIEQLLDER
                     TFFRVSRNCIANINSIRKISKYFNSRLKLSFQPECPHEVLISRVRVPDFLKW"
     PFAM_domain     complement(8366..8686)
                     /aSDomain="Response_reg"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00072.26"
                     /description="Response regulator receiver domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg91_7_0010"
                     /evalue="1.60E-14"
                     /label="ctg91_7"
                     /locus_tag="ctg91_7"
                     /protein_end="111"
                     /protein_start="4"
                     /score="54.1"
                     /tool="antismash"
                     /translation="LLVEDERFAYEEMKRMMEKLRPDYQLEAWTATVEQTVQFLKHHPV
                     DLVLLDIRLTDGYSFDIFEQMQVTTPVIFTTAYDEHAIQAFKVNSVDYLLKPVEEDDLL
                     AAL"
ORIGIN
        1 tcagaaaatc catttttagc caaacaacca tcaaaaaaga agatagatgg cggcataggc
       61 gccacaaaag ctgaaaaaca aaaatagatt gggaacccta agaaaaagga ttcacaatct
      121 attttttgtg tattagggag agacttatta caagtgggga actttttcag tgccctcatt
      181 aaaacaactc tcttttcaat gaaccctttg tgaaccctta ggcgaatata taaacctcta
      241 aatttcaacc tattgagtga gcgcattctt gttttcactc tgattttgaa tcctttgtga
      301 accctttaag cgtgtagtga gttcctttac cggttgttcc ttgtatttct aaccaattat
      361 ccaattgtga taatatccgg tatgcggtag ccttacttgt attcaacaat ctttgcacat
      421 ctgaatttgt tactgctcca ttctttgctg catactcaat aacaggcata aaccgtttat
      481 ccaaattttg cgaaacaagc tgtgaatgta catccgtgta ataggttatc atcaaaccac
      541 ttaatacttg tacgactggt ggcaacagat tataagaacc gacagcctcc aaaatacgtt
      601 tatacccacg tccccaactc tcaatatctc cacacctaaa aagagcattg gcaatggaag
      661 gattataagg acgggacgga tgtttctcaa acagcttctg tgtcgtccag tcttcaggca
      721 aacgcccggc attccaaaaa aaccacatgg tcggggtaaa cacttatctg tgtgggggtt
      781 gcatcctcat aagatttgtg agctatgcaa ttcattaaag actctcttaa tgcttcaacc
      841 ggaaactgtg gagtttcacg gcgggccccc ccctcatagg agatgctata tataagatat
      901 ttggtcttta tcaaatccat agctttgtct atctgttcca ttaaggagcc atgaacctca
      961 tcttgaaacg ccaaatcttc attatcattc cgaaagaaac ctatctttat gtatgcaccc
     1021 cgcacatatt tctcaggatc aggatgaaat agcaatacag ccgcccgagt taattgtcgg
     1081 gtatcatcat ctatcagccg cagatcatag agtaagtgct ctgtcgtatc attcaaaata
     1141 tcagcatcca cacggttgct ttttgcagct tcccggcgga aacgcctcaa tgcattagtc
     1201 gataagtcct ctattgttac acccgctatc agaaaatcat cccaattttt acctgtacgt
     1261 tgcagaataa aacgattcag ggctccgcct tttaattcct gcttcgtact acccgtacga
     1321 taatggtact gacctttata atttatcgga tttgaataag gcggcactac gatttcgatg
     1381 tattccagcc cgttttcttc cagcaagttt acatccacaa ttacgcccag aacatcacgc
     1441 actttattcg gtatatcttc caataacttt ttagcattag gagcccccac cacttttcca
     1501 ttatcgtcca tacctatata tattttaccg cctacggcat tggcgaaacc gcatatccat
     1561 ttcagatatt cgtcacgcca gctttctttc cattctatat tttgattctc actcatatac
     1621 ttgtacttta tcagatgcaa aaagactaaa aacgctaatc attaaagaag aataatgttt
     1681 attctttccc tctaatcaga caacattgca ggaatattct tgtattattc tacgcagcat
     1741 caatttaaca tagcgataac atagcaataa cacaacttct tccactaacc ccgtactttt
     1801 gcttcacaga aaaaatactc cttaaaacaa tacacggcta atgagatgat agcccaaaaa
     1861 cagcaagtaa acattaagta gcaaataata aaaacagaga taaaatgaaa aaaggtacca
     1921 agatcaaaca acatgacatc accgattgcg gagcagcctg tctggcttcc gtatgcgccc
     1981 actacggact gcgcttcccg gtatcgcgca tccgccaata tgcattcacc gaccagaaag
     2041 gtacgaatgt attaggactg atagaagccg ccaacaaact gggattgtcc gccaaaggcg
     2101 tccgcgcaca gttcgatgca ctgtacacga ttcccaagcc aaccatcgca catgtgctgg
     2161 taaatcacaa acaacttcaa cactttgttg taatctacaa agtgacgaag acacacatca
     2221 catatatgga tcccggagac ggacggatgc ataaggtttt acacgaagac ttccggcacg
     2281 actggacagg tatactggta ttgatggaac cggaagagac cttcaaaaag ggaaatcagc
     2341 aaaccagcat gagcaagaaa ttcctttcat tgctggcacc ccataagtcc gtaatgctgc
     2401 aagccgtctt cggtgcactt gttttcagta ttttgggatt atccacttct atctatgtag
     2461 gcaaaatcac agactatgta ctggtcgaca aaaacaccaa tttgctgaat ctgatgggag
     2521 tgattatgct cattatcctg ttgctgcgta ccttcatcgg tgcaatgaaa agcattctgg
     2581 cactgaaaac cggacaaaga atcgatgcag ccctgatcct gggatattac aaacacctgc
     2641 tgaccctgcc tcaacaattc tttgacacca tgcgcgtagg agaaatcatt tcacgcgtga
     2701 acgatgccgt gaaaatacgc aacttcatca acaacgtatc tctcgatctg gtagtgaata
     2761 tcatgatact ggtgttctcc ctgtgcctga tgttcattta ttcctggaaa ctggcagtca
     2821 tgaccctgat atctgcaccg ctattcctgc tcatcttctg gggcttcaac aagctgaacc
     2881 ggaaatacca acgcagcatc atggaaagca gtgccgatct ggaatcccaa ttggtagagt
     2941 ccatcaattc catttcaacc attaagcgtt tcggcatcga agagtatgcc aacctgaaga
     3001 cagaaagtcg ttttgtacat ttattgaaga atacttaccg aagtatttac ggttccatcc
     3061 tggcacaagg aggcatccaa ttcgtatcta caggaatcac aatcgccatc ttgtggctgg
     3121 gcagcattct ggttatcgat caggagatga cacccggcac gctcatggta ttctattctc
     3181 tggtcggtta cgtcatctcg cccatcggtt cgctgatatc atctaaccag actattcagg
     3241 atgcattgat agccgccgac cgtctgtttc agattatgga tttggaaagg gagcaggaca
     3301 atgaacaaaa gatcattctg gaaccggaca tgatgggcga catcattttt gagaatgttt
     3361 ctttcagata cggttcacgc aaggaagtat tcaactccct gaatctaacc atagaaaagg
     3421 gcaagactac tgccgtcatc ggagaaagcg gttcgggtaa aacaacactg atttcccttt
     3481 tacagcacat ctaccccatt caatccggac gcatccgcat tggagactat gacattgcac
     3541 agattgacaa tcgcagcctc cggcgccggg taggtaccgt tccccaacaa atcgagctgt
     3601 ttgccggaac cgtcaccgaa aacatcgcac tcggtgatac gcaaccggac atgaaacgta
     3661 ttagcagtct ggtgaaacag ctcggcctga cagattttat agacaggctg cctaatggct
     3721 acatgactca agtaggcgaa cacggcgcca ccctttccgg aggcgagcgt cagagacttg
     3781 ccatagcccg cgccctgtat aaagaaccgg aaatcctgat tttcgatgaa gccacttcgt
     3841 cactggattc catagccgaa cgttatgtaa aagaaacact ggatgcattg gccggaaagg
     3901 ggaaaacggt aatcatcatt gcccaccgac tgactacagt gagatgtgcc gacaacattg
     3961 tagtgattga caagggtaaa gtggcagaaa ccggcacaca cagccagctc tacgatgcag
     4021 gtggctcata cttcaggctt tggaacgagc agtttgccat gctggaataa tcttaacata
     4081 gcaataacat ttctataaca tcgtttgagc tgtcagtgtt ctatttttgc aacaacaaag
     4141 caatagaatc atacagtaat caaacgatgt tatttttatg aagaaattaa taatgataag
     4201 cgtggcaatc acgactttcg cctttatcgg caatgtacag gcacaaaata gaagatggtc
     4261 tctccaagag tgcatcgatc acgccatccg gcacaatatt gaagtaaaac aaagccggaa
     4321 ccgtattgaa aaactaaaag tagaaaaaag cactttaaaa aacagtttcc tgcccgacct
     4381 cagtgccgga acttctcaga agttcgactt cggacgctca ctcaatcgca gtaatgcata
     4441 cgaagacagc aatacacaaa gttcttcctt ctccgtaagc gcagaaatgc ctctttttac
     4501 aggtttccgg cggagtgcat ccgtatcacg caacaagttc gacctgatgg cagccgaagc
     4561 tgataaggaa cttatagaaa acgatttatc actgaatgtc acaagctgct atttccagat
     4621 tctgctgaac aaggaaatcc ataagattgc ccgggagcaa atccgtttga cccgggaaca
     4681 agaagaccgg acattacttc tgatagaaaa cggcaaagca ccgcaatccc aactatatga
     4741 tgtcaaagct caattggctg acgatgaact gacggcaacg gaagccaaaa actcgctccg
     4801 tctctccctc ctcgacctca tacagctcat ggaactgcaa gggcatgagg agttcgacat
     4861 cgattctctt gatgagaaca tatcccggac agataccatc atgccccaaa acatctatgc
     4921 agccgcactg aactgtatgc ctcaaataaa acaggcctat tattcactgc aaagcagttc
     4981 aaaagccatc aaagtggcca aagcaggata ctaccccacg ctttcattgg gtgcaggtat
     5041 cagtaccggc tattaccatt cggggaacag cataaatcca tccttcaggc agcaactcca
     5101 aaataatatg cagaaaagtg tctatttatc actgagtatc cctcttttcg accgattttc
     5161 aacccggaat gaagtccgca ccgcacgaat agaagagagt aatgcccgtc tgtctctgga
     5221 aaatgagaaa aagaacctat ataaggagat tgaaaaagct tatacggatg cagtgaacgc
     5281 attggaaaaa tacgaatcga cctccaaagc cgtcgttgcc aatgaagagg cacatcgcta
     5341 tgctttggag aagtatgctt cggggaagtc agccgtatat gaatacaacg aaataaaaat
     5401 gaaactggca gaggcattat cgaaacaatc acaagcaaag tatgcgtatc tgctaaaaga
     5461 gcgagtattg gcattctact catgcagaga atcagcacta agccattgat tatttctttt
     5521 tgcccggttg tttctgtatc tctacagtaa gcattaccgg gtgttaacct tggctgacaa
     5581 gcctgccaac cttggttaac cggctcgtca accaaggttg ataggcctgt taacctaggt
     5641 caacacccgg ctacccctaa gggtaaaggg atagatcact ggttctcaac acaataaccc
     5701 ctgatataaa gtaaatatat gcatcatcct gatccggatt gattgcaaga gtgagagctc
     5761 cttttttgct ctcactctta aaagttgctc tcactaacac ttaagattct tattattact
     5821 gctttatata caaagtgaga gcagtgagag caacttgatc caactttttg ttgaacgcat
     5881 tctgtctaaa acccacactt cactccggcg gaaaagtaaa ccgtcggatt gaaatacgga
     5941 tcatctttat cactgaacat attgtctaca aaccctttaa gcgtacgttt agtcagatct
     6001 ccagacctga gccaattgcc ccctatcccc aaatacaggc acgacttctt acctattttg
     6061 tattccggac agagataaga tcgcatcata accgaagcat atatcataga cttcccctct
     6121 acatccatca cagaagatat cccatccatt tccattgcca ccaacctcag cttaaaccga
     6181 tctcccaaac gtaccgcccc ggacacctca acaccggaag agagattcac attgacctca
     6241 taattaccgg aaagctgcca gttaagaaag aacatcggca tggcaatagg cactccaaat
     6301 gaattcgtca atccagcccc aacacctata tccagatttt tcctgcattt atacacaaaa
     6361 atcactcccc cattcaccaa tacactctgc caggtaattg catccggtgc cgaataaata
     6421 cctgctccca aactggctat catgtaccac ttcttcgaca agggccgtac atgtgtcagg
     6481 ttaaggctgc cactcaacac ctcatccgga tgtatatcca aagccatctg tcgattatta
     6541 agcatcgcat aagtccctct gaccgatgcc gaccacatga caggttgtcc tgatgcattc
     6601 tgcttcagcg aaaagggcag cgtatatgct ccggtgaatt ttaataaatc gcccgaaccc
     6661 aatttattcc ccgcttcatc tctgaaagaa gaggcaggca tatactccgt tttaataact
     6721 ccttgtgcaa aaccatcgat tgctgccacc aagagcaaca gaaataaaaa ataagagaat
     6781 cgtctcattg ctaataaatt agattatttt attgcaaaga aaagagatta gcttgtccgg
     6841 tataagtctt ttccgacgaa ctgcatgaaa gacctgttga atttcattat cccaaagatg
     6901 gaacaaaagg aaaaaagaag attattcgag gaaaggtact ctcactacaa attctgtagt
     6961 acttttcacg atatcaatta ctttatcata caaggcgtat tgtttttcca gattccctaa
     7021 tcctacacca cctctatcta ctgaactccg caattgcaga ttattggaaa ccatgatccc
     7081 ctcatcggta aagcctatcc gaacaataag tggattcttt aaagtagcta tattatgctt
     7141 aatcgcattt tctaccagca gttgcaagct gacgggaatg attaatctgg ttccgtacaa
     7201 atcatattcg tctatctcga tgaacaatgt atcttcaaag cgaatcttct ccagaaatac
     7261 atagctttcc agaaaagcca gttcttcctt caaagtaacc atcggacgat tgtttgtcaa
     7321 caacagataa cggtagacac ctgacagctt tttagcaaac agattggtct tttccgcatc
     7381 actataggcc agtgaggata gcacattcag actattgaac aggaaatgtg gatttatctg
     7441 ggctttcaag gtttcatact gatactgaat cttctctttc tctataattg ccagtttctt
     7501 ctctgcttcc atttggcttt gctgataaaa gaatatctca atcagaagaa caatcatgct
     7561 attccaaagt actaccggca gagacatttt cagcagagca taatcttccg gccaaggttc
     7621 ctccagaata atggacagga tataatttgc cgctatgccg aagcaactca cccatacgga
     7681 tgccaacaat aaatcgataa agattctcat tgtattgtta atgttgtcca gcttcttatg
     7741 gacaataaca atgatgagaa agtcaacaat ccccacaaaa atgcaggcag gtaaattgag
     7801 cagatactgt gtctccaaac tcaggctccg gggagcgtca gaaagaagct ccgccacata
     7861 ctggaatgca aacagagaaa ttgcaatgat cactatgaaa agcaggatat accatttatt
     7921 cttcatcccc aaatgtattt taaagcacac catccaccca cttcaggaaa tcaggaaccc
     7981 gcacacgact gattaaaacc tcgtgcggac attcaggctg gaagctcaac ttcaacctac
     8041 tattgaagta cttggatatc ttacggatag aattgatatt ggcaatgcaa ttgcgggaaa
     8101 cacggaagaa agtcctctca tccagcaact gctctatctg ttccaaagta tagtccacaa
     8161 tatagcgttt atctgaaaag gtatgcagaa agactacttt ctcttcactg tagaagaaag
     8221 cgatatccga agtctccaca taatgatatg catcaccttt ctggataagg aaacggttct
     8281 ttttacaatt actcatcaat gcttcttcca gtttcctgta atcggtagcg ggaggttgca
     8341 caaccctgaa ctgttcaaat ttcctcaatg ccgccagtaa atcatcttcc tccacaggct
     8401 tcagcagata atccacacta ttcaccttaa atgcctgtat ggcatgctca tcataggcgg
     8461 tagtaaagat aacaggcgtc gtaacctgca tctgctcaaa aatgtcgaaa ctgtatccat
     8521 ccgtcaaccg gatatccagc aacaccaaat ctaccggatg atgtttcaga aattgtacgg
     8581 tctgctccac agtggctgtc catgcctcca attgataatc ggggcgtaac ttctccatca
     8641 tccgcttcat ttcttcgtaa gcgaaacgtt cgtcttctac taacaggtat ttcatcatcc
     8701 gtcactcaat ttataggaat ctgccgtaac cgaaaactga cattatttct tcagtaaccg
     8761 ccgcgtcaaa tagtgcaccg gataccacac cgaaaggaat ccgacagtaa tcaccgtaat
     8821 aaatatcagt actacatccg ttgcatgcac actgactgga taagcatcca caataaagct
     8881 gccactaccg ccacctaagg agatgatgcc aaaacgctgc tggatatagc aaagcaacag
     8941 ccccaaaaca ataccggaaa gtgcaccgaa cagggaaata agccgacctt caaacaaaaa
     9001 tatacgggct atcaagcggt catcagctcc aagattacgc agagtctcca cgtcttcgcg
     9061 tttatccagg
//
