LOCUS       NZ_HE998568.1          20558 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  NZ_HE998568.1 Holdemania massiliensis AP2, whole genome shotgun
            sequence.
ACCESSION   NZ_HE998568
VERSION     NZ_HE998568.1
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 6.1.1
            Run date     :: 2024-03-14 13:55:36
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 353454
            Orig. end    :: 374012
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..20558
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[363454:364012](-)"
                     /cutoff="20000"
                     /detection_rule="(TIGR04223 or AgrB)"
                     /neighbourhood="10000"
                     /product="cyclic-lactone-autoinducer"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..10558)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(TIGR04223 or AgrB)"
                     /neighbourhood="10000"
                     /product="cyclic-lactone-autoinducer"
                     /protocluster_number="1"
     cand_cluster    1..20558
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(TIGR04223 or AgrB)"
                     /kind="single"
                     /product="cyclic-lactone-autoinducer"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..20558
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="cyclic-lactone-autoinducer"
                     /region_number="2"
                     /rules="(TIGR04223 or AgrB)"
                     /tool="antismash"
     CDS             complement(9178..9588)
                     /locus_tag="ctg2_304"
                     /transl_table=11
                     /translation="MQGKRGLLLILILSLLAGCQSKTQMSAEQQYLQTLQKSQAELTAL
                     FENGQPQSPDWLAQLSAIGEQWSEPEETYHGSDEEVAGLAQAYEKMGKQVCVIAEALQH
                     QATEKAIDELEKLKSEAGKNGEKLNEIVQRWN"
     CDS             complement(9748..9855)
                     /locus_tag="ctg2_305"
                     /transl_table=11
                     /translation="MRQRFWKTAAMLVLAMAAISKLTISQWGWYQPEED"
     CDS             complement(10001..10558)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     cyclic-lactone-autoinducer: AgrB"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg2_306"
                     /sec_met_domain="AgrB (E-value: 5.6e-27, bitscore: 90.0,
                     seeds: 181, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRNFSLKLGRWLNGQLNEPVNENDLRFGIENLLIQGILILCMTGI
                     ALVFNCVQEMLVFMLSLMAVRSFTGGIHLHRFSHCLLVTHSVCFGCIALTQFIPNPGIY
                     VLLDLLSLGIIWKWAPDMRYKRRKTEQDRQRARRLSRILTSICGIFSVIELLAINQGMG
                     RIIACSLTASAISLALAQKTVQ"
     PFAM_domain     complement(10031..10498)
                     /aSDomain="AgrB"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF04647.17"
                     /description="Accessory gene regulator B"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg2_306_0019"
                     /evalue="9.00E-26"
                     /label="ctg2_306"
                     /locus_tag="ctg2_306"
                     /protein_end="176"
                     /protein_start="20"
                     /score="90.4"
                     /tool="antismash"
                     /translation="NENDLRFGIENLLIQGILILCMTGIALVFNCVQEMLVFMLSLMAV
                     RSFTGGIHLHRFSHCLLVTHSVCFGCIALTQFIPNPGIYVLLDLLSLGIIWKWAPDMRY
                     KRRKTEQDRQRARRLSRILTSICGIFSVIELLAINQGMGRIIACSLTASAIS"
     CDS             complement(10551..11828)
                     /locus_tag="ctg2_307"
                     /transl_table=11
                     /translation="MNAFVIEFSFCLLEMLSVTLLVQKFFALRVSLPVLLLSLLGFAAV
                     EYSMEFWMADPTLLVLLMFLNMMIMIRLVFTGKTMNLGILVLLFYIAEGILSVISFQVL
                     TLGAKIPIEVLMQENWLRTLGGYFNKLAILTPIVLMKKKPELLRYENLSWMFRFSCLLL
                     FLCVFFNYLICCTFNDRRIRILSAALSAALFGFFVLMNWVFLQYRQMRESKKRLEIEHN
                     CNTLKAVWLAETLENQEKYRKQRHDLKHLLGLLELYLSQERSLEALEYIRSTMKTVEDI
                     SRKEHTGDPIIDSLLNRTIESEPHLQFHLETGRVQWSLKEVDTCILISNLLSNAVEAAK
                     LSQQKEIKLYLKEDETTIYLTLINSVKPNLRINLKRSSKSDWEEHGYGIESIRTIVKQA
                     EGELDFHLASDRFEVRILLPKEEKHA"
     PFAM_domain     complement(10572..10871)
                     /aSDomain="HATPase_c_5"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF14501.8"
                     /description="GHKL domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg2_307_0020"
                     /evalue="1.40E-20"
                     /label="ctg2_307"
                     /locus_tag="ctg2_307"
                     /protein_end="419"
                     /protein_start="319"
                     /score="73.1"
                     /tool="antismash"
                     /translation="KEVDTCILISNLLSNAVEAAKLSQQKEIKLYLKEDETTIYLTLIN
                     SVKPNLRINLKRSSKSDWEEHGYGIESIRTIVKQAEGELDFHLASDRFEVRILLP"
     CDS             complement(11825..12526)
                     /locus_tag="ctg2_308"
                     /transl_table=11
                     /translation="MIKAAIVDDDLEFLEMMSGELEKTQLFGEIKTYNDPQKLIATLGQ
                     IASDVLFLDIEMPNINGFSVAKALREQPVSPLIVYVTAEEHYMAEAFGFHVIGFLVKSK
                     LQEQLAGMIIKINEEIAYRQVTVETTQGKISIRRDQILMLSCFNRKVTLTLQGGIKYEL
                     RGRVLNDAVCVLAMREYLVQINRSEVVNLMNVEKIKANTLFIRGLSQPLMISKYQKAEV
                     LRRFSDYKVMV"
     PFAM_domain     complement(11858..12127)
                     /aSDomain="LytTR"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF04397.17"
                     /description="LytTr DNA-binding domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg2_308_0022"
                     /evalue="5.60E-05"
                     /label="ctg2_308"
                     /locus_tag="ctg2_308"
                     /protein_end="223"
                     /protein_start="133"
                     /score="23.4"
                     /tool="antismash"
                     /translation="ISIRRDQILMLSCFNRKVTLTLQGGIKYELRGRVLNDAVCVLAMR
                     EYLVQINRSEVVNLMNVEKIKANTLFIRGLSQPLMISKYQKAEVL"
     PFAM_domain     complement(12194..12511)
                     /aSDomain="Response_reg"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00072.26"
                     /description="Response regulator receiver domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg2_308_0021"
                     /evalue="1.10E-15"
                     /label="ctg2_308"
                     /locus_tag="ctg2_308"
                     /protein_end="111"
                     /protein_start="5"
                     /score="57.8"
                     /tool="antismash"
                     /translation="IVDDDLEFLEMMSGELEKTQLFGEIKTYNDPQKLIATLGQIASDV
                     LFLDIEMPNINGFSVAKALREQPVSPLIVYVTAEEHYMAEAFGFHVIGFLVKSKLQEQL
                     AG"
     CDS             complement(12648..14624)
                     /locus_tag="ctg2_309"
                     /transl_table=11
                     /translation="MNKLKKILISFAVLGMITGCSPVPDSSSGSGPVTLRIGTWNIASQ
                     KHPDPQAMAAVLAKHRLDAVGIQEVDVQNNRNSQDLAQAFVNDDVPYVHFAKGRDFADG
                     AFGIGIVSQHELLQVSSIPLESTGSRATKTLERVVIEKDGVQIALYNTHLSWENLDLRR
                     RQIAQVIQRVNADPMEYKVITGDFNTDQHEYEYSMFLDNFNVANGYKSMWYDTYREADD
                     PSMNVFTIDNVLCTKNMRITDIQRVESDLSDHDLFYAEFELLGEVEGLANSDNRALGQN
                     VIVSSLNEEISPYLLVDYDTKTPWVSDAADQQFITIELDRVYAVDQIHVLWDTVKAKQY
                     LVSGSLDGESYQTLAEIQDVKDSDAIAVNNQPVKFVRLELSGKKAANQGYEITEIQIFG
                     DPLSPQIDSANRLPQGSFEVWNGNQPEGWNWTVVQAEEHSGSAAFVLSADTAAKTAGSS
                     SLMLTQSGIRSGIDGVLSTSAAVKPNTTYQLVFDHRAQQLSSTDFTIEMTQKTANGESI
                     STHQVTLNDNLCMSEEWAVYSLNFVTAYSADSLDLSFRLSGAEGTLWLDDVQIREAVPT
                     ENIFLKTEAAALKAGEKTTVTGERLPEAASDVTLHWFSSDERVAVVDEQGQVTAVKPGK
                     AYIGLCSGSELRVESSLLVTVEE"
     PFAM_domain     complement(12696..12893)
                     /aSDomain="Big_2"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF02368.20"
                     /description="Bacterial Ig-like domain (group 2)"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg2_309_0025"
                     /evalue="3.20E-09"
                     /label="ctg2_309"
                     /locus_tag="ctg2_309"
                     /protein_end="643"
                     /protein_start="577"
                     /score="36.6"
                     /tool="antismash"
                     /translation="NIFLKTEAAALKAGEKTTVTGERLPEAASDVTLHWFSSDERVAVV
                     DEQGQVTAVKPGKAYIGLCSG"
     PFAM_domain     complement(13479..13763)
                     /aSDomain="F5_F8_type_C"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00754.27"
                     /description="F5/8 type C domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg2_309_0024"
                     /evalue="5.90E-09"
                     /label="ctg2_309"
                     /locus_tag="ctg2_309"
                     /protein_end="382"
                     /protein_start="287"
                     /score="36.2"
                     /tool="antismash"
                     /translation="NEEISPYLLVDYDTKTPWVSDAADQQFITIELDRVYAVDQIHVLW
                     DTVKAKQYLVSGSLDGESYQTLAEIQDVKDSDAIAVNNQPVKFVRLELSG"
     PFAM_domain     complement(14004..14513)
                     /aSDomain="Exo_endo_phos"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF03372.25"
                     /description="Endonuclease/Exonuclease/phosphatase family"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg2_309_0023"
                     /evalue="6.10E-11"
                     /label="ctg2_309"
                     /locus_tag="ctg2_309"
                     /protein_end="207"
                     /protein_start="37"
                     /score="42.5"
                     /tool="antismash"
                     /translation="GTWNIASQKHPDPQAMAAVLAKHRLDAVGIQEVDVQNNRNSQDLA
                     QAFVNDDVPYVHFAKGRDFADGAFGIGIVSQHELLQVSSIPLESTGSRATKTLERVVIE
                     KDGVQIALYNTHLSWENLDLRRRQIAQVIQRVNADPMEYKVITGDFNTDQHEYEYSMFL
                     DNFNVAN"
     CDS             14785..15690
                     /gene_functions="regulatory (smcogs) SMCOG1014:LysR family
                     transcriptional regulator (Score: 141.2; E-value: 6.6e-43)"
                     /gene_kind="regulatory"
                     /locus_tag="ctg2_310"
                     /transl_table=11
                     /translation="MLDYRLKTFLLLSKTLNYTKTAQQLHMSQPAVSQHIRYLEQTYNI
                     KLFEYYNRRLQLTEMGQRFYQQVLALEVQSQDIIERLRQEQENRRLLRFDCTFTFGEYI
                     MPPLICRWMKENPNTELCMRILGTAACLEALDQGEIDFALVEGFFDKAVYESRLVKMTH
                     MGLVVPVGHPLTQKKEVMLNDLIAYPLVVRQKESRMRGILPTGLAEHNLSYESFAGMVQ
                     CGSMNVMKTLIKNGCGIGFLHEDIIHADLVEGTLVEIPVVDFVLKRELNMVYLPHHQDP
                     ALLDQIYQDLCEHLRQLGTD"
     PFAM_domain     14797..14970
                     /aSDomain="HTH_1"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00126.29"
                     /description="Bacterial regulatory helix-turn-helix
                     protein, lysR family"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg2_310_0026"
                     /evalue="1.20E-15"
                     /label="ctg2_310"
                     /locus_tag="ctg2_310"
                     /protein_end="62"
                     /protein_start="4"
                     /score="57.3"
                     /tool="antismash"
                     /translation="RLKTFLLLSKTLNYTKTAQQLHMSQPAVSQHIRYLEQTYNIKLFE
                     YYNRRLQLTEMGQ"
     PFAM_domain     15040..15642
                     /aSDomain="LysR_substrate"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF03466.22"
                     /description="LysR substrate binding domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg2_310_0027"
                     /evalue="8.30E-35"
                     /label="ctg2_310"
                     /locus_tag="ctg2_310"
                     /protein_end="286"
                     /protein_start="85"
                     /score="120.2"
                     /tool="antismash"
                     /translation="QENRRLLRFDCTFTFGEYIMPPLICRWMKENPNTELCMRILGTAA
                     CLEALDQGEIDFALVEGFFDKAVYESRLVKMTHMGLVVPVGHPLTQKKEVMLNDLIAYP
                     LVVRQKESRMRGILPTGLAEHNLSYESFAGMVQCGSMNVMKTLIKNGCGIGFLHEDIIH
                     ADLVEGTLVEIPVVDFVLKRELNMVYLPHHQDPALLDQ"
     CDS             complement(16002..16709)
                     /locus_tag="ctg2_311"
                     /transl_table=11
                     /translation="MMRGWNPESHRQFLTDFYTGQALGSFAEGESDPESGRCYGTLASW
                     AGCGRAMDHHEPYELENSCRRVLLLQGLSLAMRGMPLLSDGDELGALNDVSFRLDPDKE
                     QDRRWLQRPVYIEEKAQQRFQLLSLEYRIFQSLKAMLQVRSDYPDWNCGQEQILDTGND
                     ALLVWSRSCKKQRLLFLFNFTESPQYCPLTSLFNKEEQARELLTGRRISGSQETLDLKA
                     YEFLWLIVEAGVD"
     PFAM_domain     complement(16038..16202)
                     /aSDomain="Glyco_hydro_42C"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF08533.12"
                     /description="Beta-galactosidase C-terminal domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg2_311_0028"
                     /evalue="1.30E-05"
                     /label="ctg2_311"
                     /locus_tag="ctg2_311"
                     /protein_end="224"
                     /protein_start="169"
                     /score="25.0"
                     /tool="antismash"
                     /translation="RSCKKQRLLFLFNFTESPQYCPLTSLFNKEEQARELLTGRRISGS
                     QETLDLKAYE"
     CDS             complement(16723..17760)
                     /locus_tag="ctg2_312"
                     /transl_table=11
                     /translation="MSAGEFLQRLQPLMAEMEAAFFRIYQPFHVQEETFDALLAMLDEQ
                     RLNRSLLHRGKDRGPAWFCSAPAGMRLNYSAAQSAAQISLRAKELRELGIGWVQLSEVP
                     FPHTQRSRQVLQTEIDAWHAEGFAVGIDFDVAGTPQDDPWASQALKGDLSMQQRYWMIA
                     DAKLASLYSPFSKENETGVFYKLEKIHQYVYRSPQTGGWLLDYKNPQVLSVMLKRFCSL
                     ADLGVDAIELRQLDHMWKECKAQPLYPQIPDLFALFVAAGKLVCPSVLVIGHSEAAAHD
                     LQILAQRAPQSASVLDQAAMINSWNSLATRDTKMQRADLIFSCADPSHDRDSPGGLRSG
                     PPLEF"
     CDS             complement(17764..18729)
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1276:PfkB domain protein (Score: 226.7; E-value:
                     6.5e-69)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg2_313"
                     /transl_table=11
                     /translation="MKICSFGETLIDFTPVGVSENGNILFERNPGGAPANLAVAAVKHG
                     VQASFIGEVGDDIFGQFLNEKLKGEGVDTEYMVINSRYKTTLAFVQLDEKGERSFCFYR
                     NPGADTMIESQEVNLRAIDECELFHYGSVSMTHNPARITTFELIKYAQQKGKLLSFDPN
                     LRMPLWNSEEEARHEIRHGLQFCDILKVAEEELIFLTGCKTLEEGARQIAKKYKTPLIL
                     VTEGSQGSHALIHDYYINAPAFPVSVVDTTGAGDGFLGCFLASFLKSEKTLEQLSGEDV
                     YQMLRLANASGALSVTRKGGMPSLVTTEEAQALLDQQPES"
     PFAM_domain     complement(17815..18726)
                     /aSDomain="PfkB"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00294.26"
                     /description="pfkB family carbohydrate kinase"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg2_313_0029"
                     /evalue="2.40E-63"
                     /label="ctg2_313"
                     /locus_tag="ctg2_313"
                     /protein_end="305"
                     /protein_start="1"
                     /score="214.3"
                     /tool="antismash"
                     /translation="KICSFGETLIDFTPVGVSENGNILFERNPGGAPANLAVAAVKHGV
                     QASFIGEVGDDIFGQFLNEKLKGEGVDTEYMVINSRYKTTLAFVQLDEKGERSFCFYRN
                     PGADTMIESQEVNLRAIDECELFHYGSVSMTHNPARITTFELIKYAQQKGKLLSFDPNL
                     RMPLWNSEEEARHEIRHGLQFCDILKVAEEELIFLTGCKTLEEGARQIAKKYKTPLILV
                     TEGSQGSHALIHDYYINAPAFPVSVVDTTGAGDGFLGCFLASFLKSEKTLEQLSGEDVY
                     QMLRLANASGALSVTRKGGMPSL"
     CDS             complement(19065..20048)
                     /locus_tag="ctg2_314"
                     /transl_table=11
                     /translation="MNEEHFWDDPKAAQNVIRQCNGMKELEAKYHQMEQALASLQETVD
                     ELNQNFDEELKELLDMEYQDTLSQFEEFEVMVLLSHPYDKNNAILELHPGAGGTESQDW
                     ASMLYRMYCRWAERKGYKVTLLDYQEGEEAGIKSASILIEGDMAYGYLKAEKGVHRLVR
                     ISPFDSSGRRHTSFASLDVMPQFADEIEITIDEKDLDVVTMRASGAGGQHINKTDSAVR
                     MTHKPTGIVVSCQTERSQIQNRERCMNMLKSKLYQRMIEEQEAKLAAIRGEQKNIEWGS
                     QIRSYVFCPYTMVKDHRTGYEMGSVQNVMDGDLDGFIFSYLKSQIQ"
     aSDomain        complement(19074..20048)
                     /aSDomain="TIGR00020"
                     /aSTool="tigrfam"
                     /description="prfB: peptide chain release factor 2"
                     /detection="hmmscan"
                     /domain_id="TIGRFam_ctg2_314_0003"
                     /evalue="1.70E-144"
                     /identifier="TIGR00020"
                     /label="ctg2_314"
                     /locus_tag="ctg2_314"
                     /protein_end="325"
                     /protein_start="0"
                     /score="479.2"
                     /tool="antismash"
                     /translation="MNEEHFWDDPKAAQNVIRQCNGMKELEAKYHQMEQALASLQETVD
                     ELNQNFDEELKELLDMEYQDTLSQFEEFEVMVLLSHPYDKNNAILELHPGAGGTESQDW
                     ASMLYRMYCRWAERKGYKVTLLDYQEGEEAGIKSASILIEGDMAYGYLKAEKGVHRLVR
                     ISPFDSSGRRHTSFASLDVMPQFADEIEITIDEKDLDVVTMRASGAGGQHINKTDSAVR
                     MTHKPTGIVVSCQTERSQIQNRERCMNMLKSKLYQRMIEEQEAKLAAIRGEQKNIEWGS
                     QIRSYVFCPYTMVKDHRTGYEMGSVQNVMDGDLDGFIFSYLKSQ"
     PFAM_domain     complement(19155..19487)
                     /aSDomain="RF-1"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00472.22"
                     /description="RF-1 domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg2_314_0031"
                     /evalue="1.80E-41"
                     /label="ctg2_314"
                     /locus_tag="ctg2_314"
                     /protein_end="298"
                     /protein_start="187"
                     /score="140.8"
                     /tool="antismash"
                     /translation="DEIEITIDEKDLDVVTMRASGAGGQHINKTDSAVRMTHKPTGIVV
                     SCQTERSQIQNRERCMNMLKSKLYQRMIEEQEAKLAAIRGEQKNIEWGSQIRSYVFCPY
                     TMVKDHR"
     PFAM_domain     complement(19512..20048)
                     /aSDomain="PCRF"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF03462.20"
                     /description="PCRF domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg2_314_0030"
                     /evalue="3.30E-59"
                     /label="ctg2_314"
                     /locus_tag="ctg2_314"
                     /protein_end="179"
                     /protein_start="0"
                     /score="200.0"
                     /tool="antismash"
                     /translation="MNEEHFWDDPKAAQNVIRQCNGMKELEAKYHQMEQALASLQETVD
                     ELNQNFDEELKELLDMEYQDTLSQFEEFEVMVLLSHPYDKNNAILELHPGAGGTESQDW
                     ASMLYRMYCRWAERKGYKVTLLDYQEGEEAGIKSASILIEGDMAYGYLKAEKGVHRLVR
                     ISPFDSSGRRHTSFAS"
ORIGIN
        1 tctttcattt ccagaggaac ctgcctagct ccctctaaag gattggattg gacttgcttc
       61 attgccattt gttcattgag atcattaggt attactcttc ccgtacttcc tttaccttca
      121 actttaacag gattgccaac accgatatta gattcttctt tttctttctc acctgttgtt
      181 cccgacgatc caccaccatt aacaatcgca gattgagtga tgcctaaagc ttcactgatt
      241 gctggattcg aggctgctgc gccttccaag gttaatgtat agccaataag ctgtccacca
      301 ttgactgccg cacttccatc cggctgcatt gtcattcctg ttgaactgcc gccgctgatg
      361 tttccctgag ctccaagtgc tccgatcgtg gtaactgctg atagaccgat catcttaaga
      421 tcttgtacgc ctttttcttt atctccgctc tcatattcat agatagcata gactgtcgct
      481 ccaccataag cggccgctgc agtatgtcca agaactgctg ccaatgcagg taaggttcca
      541 aacgaagctg ctgtcaaata cagcgctgcc gctccacctc ctattatcac cagattttcc
      601 accggatgat ccaagaagct ttgaatcgta ttcttcgtca acctcgtggc tgcatcccaa
      661 gcttccccag ctttttcgcc aacccattga attccctggc tcactttttc cttttgttca
      721 ctgcaccagc cgctaactcg attcgctatc gatccaattt tatcggttac atccttaaag
      781 ttaatgccct taaaactatt caagttgact tgtacacttc gtcttgcttc ttctttcttt
      841 gcatattccg atgtaatttt tttcatcgtg cttgtcagaa ctccatgctg ctcttctatt
      901 cgctgtttta atagttcagc agcttttttc gcatcttcct gactctttcg cgttgtgttt
      961 tttccagaag aagtattctt tgaagaactg ttggaattat tctgatatac tgtcgaattc
     1021 gaataattcg tgttattcga cggatactgg atcgccttat catattgctt atagatcggc
     1081 ggcgctgttc tcgcatccgt tggattcatt ggatttgatg gctgactctt cggcgtactc
     1141 ttctttgtat tggaggaact tggcgtgctt ttcttgcttg gcgttgtttt tttcggggta
     1201 aaggcattct ttaccgtatt cacaaccttg ttcaccgtat tggtgattgc tccccaaata
     1261 ctccacattc cccttggatc aaagtactta ttcgggttgt ttcggctata gttgtaccgg
     1321 ttctggctta acggatcctg ccaatcccca cgatacccat ccgcactgat gaacagttcc
     1381 gtcacggtat cataataccg cgctcttaag tactgcgttt catcactgtt gtgtgcttct
     1441 gagcgatacc catattcgtc actgctgctg acaaacggat tgtatttctt atctctcctt
     1501 ccataatcgc tgtagctgta tgtcgacagc acctgattgg atccgcttaa cagcattgta
     1561 acgcttcctt gaccatcgta caaatagaaa tcgtcattgg tgcacaatct ctcattgcca
     1621 taccaatact ttgtttttgc actgtcctgc gtcttcacca agacgacggg atactcggcc
     1681 agctcgtcgt tgagatactg aatcgtcgtc gtgttgccgc tgactgaccg cgtcgttgct
     1741 gagcttgcgt tctggtgcgt ttctgcggct tccagcggcg tttgtttcag ctgggcgatc
     1801 aaggtgtcga tactgtcgga aatcgcctga ggcgaggtca caggcacggt attcgtccgg
     1861 ccggcagtct gttggatccg attgcctgct ccgtcatacg catacgtcgt taccgttccg
     1921 tcgaagtcct tcactttcac cagctgattc agcttgttgt acgtgtattc cttcaccttg
     1981 ttgtcatccc ggccttcccg aatccggttg ccgttagcgt cataggcata ggtgaagtga
     2041 taagtaccat cataataggt cttgatccgg ttgaagtcgt cataggtcgc acggtaggtg
     2101 acctgccctt ccgtcacttc cgtcttattg ccagtcagtg tgatcacggt ttccgttgtc
     2161 gttttcgttg atccttgcgt cttcaccgtt ttgatcagct cgtcgttttc attgtagctg
     2221 tactctttga cggtcgttgc cccgttgagg atttccgtct gcttggccac gctgttgatc
     2281 gcgttgtaaa cataggtgta agagctgagg gttttggttc ccagcttggt cagctgggtt
     2341 aactgattcc cattgttgtc atagctcttg gtgatgacga cattgttgca catccactcc
     2401 ttggtcatcc ggcccagcgc gtcatattca taattggaat aatgcgacgc gttgacagtc
     2461 ttggtcatcc ggcctgccag atcgtattgg taggtgatgg acgtattatc cggataggtg
     2521 atcttggtgc ggttgccgta agcgtcatat tgatactgga tcgtctgatt atcccggacc
     2581 accttgattg tattgcctgc ggcatcatag gtgtattggg ttgagccatg atcgtcagtc
     2641 attgtcgcaa tccggtctaa agcgtcatac gtgaaggccg cgtccggctt ggtcagcaca
     2701 ttctggttcg cgtcataagt atacgtcaga actgtgccgt ccttctgctt tagggttaac
     2761 agattgccgt ttttatcgta ggtatattct tccgacttct tgtcttcatc tgtcgctttg
     2821 atcaattgac ctgaggtatt gtagacatac agaacctctg tttggtcata gtagcggcga
     2881 atgatcttgc ccatcttgtt cagcgtatag ttcagcttga atccgcgggc atcctgaaca
     2941 gaagtcatat tcccagcggc gtcataggta tacgtaacca aatgattcag cggatccttt
     3001 tcctgaatca ggttgtagac ggaatcataa accttttcat agcgctggcc attggcgtcg
     3061 acccgggctg tttcatagcc ggcggcattg tactccacgg ttgaaacatg gtttaatgcg
     3121 tcggtgattt tgacaagctg ctgattcaga tcataatcat agcgcgtcgt gtttccgaca
     3181 ggatcggttt cactcagaat ctggttgaac gcgtcgtagg tccaggtggt cgtcttcgcg
     3241 ttgttgactt tttcagtgag cttgttgccg gcggcatcgt aggtatagac cgttttgatg
     3301 ccggcctcat cggtcatgct gagaatccgg tcttctgggt cataagtata cgtccgcgtc
     3361 tggttcagcg catttttctg ctgaatgacg cggccggtct tatcatactg ccagcttgtt
     3421 ttgtgccgca gcgcatcgta agcctcggtc ttattgccga tcacgtcata gacattctcc
     3481 gcaaccaact tgtcatcctg ccatgttttc agcagctggt tgtaggcatt ataggaatac
     3541 ttccaaaccg agccgttggt catcgtttca ctgaccttct ggtttaaagc gttataggtt
     3601 gcggtttcaa tgccgccgtc gggatacgtt gttttcttga cattgccgaa aatatcgtat
     3661 tcgtaggctg tgattccgcc gatcttggat gtttccttaa tgcattgatt cagtgcattg
     3721 tactgccgct ggatcgtatt gcccttcgca tccttcgtag cggtcaaatt gtcatggtca
     3781 tcataggtgt attccgtcgc gtagcccagc ggatccaccg ttttggaaac cagaccggcg
     3841 ggattgtaca ccgtctgcgt gatgccgcct aagccgtcgg tttccttgat cagccggcca
     3901 tcggcgtcat aagcagtttg ccggattgtt ttgttatcca ccttttccgt taccttttga
     3961 ttcaaggcgt tgtagacaga ctgggtcgta tgaccgttgg acgtcatcgt cagcacgttg
     4021 ccttctccat cataagtcga tgtcgtgacg ttgttgttgc ggtcggtcac gctgatgaca
     4081 tggccgaaag tgtcataggc ataaagaatc gtatccccgt tgatggtttc cttgatcagg
     4141 cggtttaagg catcatattc cagcgttttg gtattctgaa ggctgtcgct ttccgagatc
     4201 ttattcccgt ttaaatcata ggtaaactgc gtcgtcacgc cgcggctgac ctgcttgatg
     4261 atcttgccgt catcgttgat cgtgtaggtc gtggtgctgc cgtaagcgtc ggtttcggaa
     4321 gtcacctgat cataaacgtc ataggtatac gtatgattga tttcaccgtt aaccttgacc
     4381 tgcgtcagcc ggtgcagcgc atccagcgtg ttctcagtga ctaagcccgt cggctcggtt
     4441 gtcttaatca gctgatcgta ggcatcatag acaaatgtcg tggttaagcc caggatagtc
     4501 tgggaggtca gattgccgaa ggtatcataa acatagcttt caatgacttt gccattgcgt
     4561 gtcttctgtg ttagatgccc gtgaacatca tagtgatagc cggtctggtt gcccagcggc
     4621 gtggtcgtta agattgtccg tccgcggctg tcgacggtca ttgtcgtgcg gttgttcagc
     4681 gcgtccttcg tttcaattac ctgatgattg ccattgtaga cataggtcgt cgtgtggccg
     4741 ttggtatcgg tagaagtgag gatattgcct tcatgatcat acgtccagct gcgcgtcttt
     4801 tccgccttgg tttcactgag cacccggccc atcgcgtcat aggtataggt tgtttcctgt
     4861 cccaaggcat ccgtcatttt tgtctttaag cctttggcgt aggtataggt tgtcgtgtgc
     4921 cccagcggat ccttgacgct tgtcagatga cccatcgcgt cgtaagtctt ttccgtcacc
     4981 ttggcctgat cattgctcgt cagcgtctgc ttgacttcat gacccagggc atcgtattca
     5041 aacgtggtcg tctgacgggt agttgcctga ctgagccgct gacctttcgc gtcataggta
     5101 taggtcgtca cattgcctgc tttgtccgta gcggttaaaa tccggcctaa gacatcgtag
     5161 gtgttgatcg tttcctttcc atcgaaatcc gtcgttttaa tgacgttgcc cagcgtgtca
     5221 taggtatagg ttttaatttg cttatgggca ttggtttctg tcgcgacacc gaactgattg
     5281 taggtgtagc tttttgtcaa accgttggct gtttccgtca ctgtccggcc gcggctgtca
     5341 accgtgcgcg atgtgactgc gccgtcgggg taggtggttt tcgtcagatt ctgattttta
     5401 tcataggtat aggttgtgac gttcccttcc gagtccgtca ttttgacaac attgccatag
     5461 agatcgtatt cataggcggt gatgtttccg tcatagtcgc tctccgtcag cttgttgccg
     5521 gccgcgtcat agatgaacga cttcgttccc ccgtccggat tgataatctg aacgatttca
     5581 ttgcgggcgt tgaggacatg ggtggttgta tgattgtcct gatcggtggc ggttaacaga
     5641 tagcctgccg cattgtaggt ataggtaaaa taggttccgt caggataggt aatcttactt
     5701 acccggccct gatcgttata ttcatagctt gtcgtctgat tcaatggatt ggtttcactg
     5761 atcagctgct tcagatcgtt gtaagcatag gttgttttat gccccagggc atcggtgtag
     5821 ctagtcttgt tgttgtgggc gtcataggtc caggcttcat tctgaccagc cgtattggac
     5881 tttgttaaca ggttgttctt ggcgtcatag gtgcgggttt ccttgaagcc gtcgctgcgc
     5941 gtcgcagtca gctgattgcc gcggtcatca taggtatagg tccagcgcac gccgttttcc
     6001 aaggtttctt ccgttaacag tcctttgaca aaggtcttta aaacctggcg gctgtccgcg
     6061 tattcaacct tggtcgtctg cccattggca tcaaaccagg tcgtttccac attgcctaac
     6121 gcgtccgtcg tctttgtgcg gccttccaga tactccaagg tcatgatgtt gccctggccg
     6181 tcgacctgtt ttgtgacgcg gtgctgatcg tcataggtat tggtgatgac taacgcctca
     6241 ttctgattcg tccacgaggt catattgtga tctgcatcat acgtgtattc gatcaccgcg
     6301 ccggtctggt cggtaaagga gatcagattc aggttggcat catagccata gctgacctta
     6361 tccgtttctg acagccggat ttcatcaacc agattctccg cattgtaatg gaaggtcatc
     6421 gtcttgccgt cttttaaagt gatcgtcttc ggcagacctt gagtgtaggt aaacgttgtt
     6481 tcgcgtccct gcttgtcgat gttcttggtt actaatccct gggcgttgta aatccaggtt
     6541 gtatcctgat ttttcagcac aaagtgatcg gtatcccagc tcagcttcat cgtcgttgtc
     6601 agcgtgttgg cataggtgcc gtcggcttgc ttcgcgaagt aatatttcgt gccgtcttcc
     6661 agcatcacgg ttgcgccctg atcgtcgctg gcaacccggg ataatccgct gaacgcccag
     6721 cccatgccga agatgctgaa gactccggcg gcgctgctgt tgtaagcgcg ggagaatgta
     6781 aacgtttcat ccagcacgtt catcgcgaaa tcctgacttt ccaggataaa gttgccggtg
     6841 ttcaggttaa tcggctcaaa gccgaattcg cactgcacat cgcgtccgcg cagcgccgcg
     6901 tcgacctgct tcttctgatc tgtcgacagg tcttcctcca cataatcgac gtctttgttt
     6961 ttctgcggtt cgcggataaa cagaatattt ccctgagtga tcaattcatc ctgcaggttg
     7021 ttgtccttca tcagggtttc tttggaaatc ccgtagaagg aagcgatcga gctgactaag
     7081 tcaaaacctt tcacctcata ggttctaaag taggtttcct tgaccgcgct cttctgggtt
     7141 cccttcaccg attggaattg cacggtatac agcttgcccg gctcaaagct gtcaaagaac
     7201 ttcccggttt gataattgct gaccttgacg ccattgtagc tttgtgtttt ctcaatttcc
     7261 ggatagtccg gataacggta aaagttatct accgcttcca tggtttccgt aaacttcacg
     7321 gtttccccgt ctttaatcgt aacggttgtc tgggcatgat acggcgccgt gccgtcaaat
     7381 ccgaccgcga ctaaatacgc taagccttcc tgatagtcat atttgacaaa cgggcggaca
     7441 ttgaacgtaa actgattgac gtcggtcatc gtgacatccg ggctgtcgta atattccgct
     7501 tcaacatacg gcgtatcctc accggtgccg gtgatgtaat aatattctga agcgtacatc
     7561 tccagatagc tggattccgg atccttcagg gttaacagca cgccgttgtt gggcttgttg
     7621 ttttccgcaa cgtctttaac atagggtgta atatcgagcg aatgcagcca aaagccctcc
     7681 caggtccaat cgctggtaaa gcagtcgtaa ttggccggca tgttcaaata agtcgctttg
     7741 gaaatatcat aagtccccgg gatgctgcag gcaagcagct cattggtcgt ccccggcttg
     7801 gtttttccct gaacgatatt cagcgttgct tttttgatgt atttgccttt caagacttca
     7861 ttcatgcggt catcgttaat tttataaaag ctgaaggcgt gcgcataacg cggatgatta
     7921 ccgataaaca aaaacgcgtc gtcatagttt tttaacaccc agccgtccgc ttccatattc
     7981 ggattgccca gcgtcttggt cggacggctt tgagaaacac tgacgtcagt tccgttgtga
     8041 gcatagccga aataattggg atcgatcacg actggataaa cccggtcttc gctcatcagc
     8101 cagctctcgt ccacgctgta atgaacaaga ttttcttcta aggacacgaa aacctcggtt
     8161 tcattgcccg ctgcatcctt agccttcggc gcccggatca gcatggccag ctgttcgttc
     8221 tgatcgacaa caaccaagcc atgctcgtcg ccctgccgga ctgttccgtt ttcaacggtg
     8281 atctggctgt caaaagtatt cgctgccggc ttttcataca gaaccagttc ctcttccacc
     8341 caggccggca tgaccgtata gcgcagattc acctgatttt ccatcggata gatcagctgc
     8401 gccccctcca cgctcggttc gccgatttgt ttcagctgcg gaattactgt aatccgaaca
     8461 tcgtcttttt ccaagacaac gccggttttg gaatccgctg gataatagct gcggacaaca
     8521 ttcgccgtat tctgcacaaa aataccctgg ccctcctcag aaagcaggtt cactgccggc
     8581 gtcagctggg tatcaatcgg cgcaaagcca ttctccgtct tataattccg aatgacgccc
     8641 atgaccattt ttttcagatt ctggtcttct ttattggtgt aaatcactgt tctttcatcc
     8701 acaatttccg gattcgtata atcctcaggc tgagaatctg ccggattcgt atccgtctgt
     8761 gtaaattcca gcggtgccgc ggacgctggt gtttcaccgg ctgttggcgt cggcaccagc
     8821 gtcggctgag gtgtttgtac aggaatctgc gttggttctg ccgagggttc tgtcgagggg
     8881 tcagccgttg gctgcgcagt cggctcctcc gttatttccg gtgtttcagc cggcttgggt
     8941 tcggctgttg catcaacact cggcgtgggc tggagttctt cgccctctgt tggctcactc
     9001 ccattttctg attcttccga atctttgttg ttgacgggat cattttcagt aatatcaacg
     9061 ttgtagtaag gtcctgtctg attgtatttt tcaatgattc tgcgctcatt gactgcccgg
     9121 atcatatccg tgttctgtat cagcatacag aaactgaaca gacagatcat aagcttttta
     9181 attccaccgc tgaacgattt catttaattt ttccccattc tttcctgctt cagattttag
     9241 tttttccagt tcatcaatcg ctttttctgt ggcttgatgt tgtaaggcct cagcgatcac
     9301 acagacttgc tttcccattt tttcataggc ctgtgctaag cctgcgactt cctcgtcgct
     9361 gccgtggtaa gtctcctccg gttcactcca ttgctcgccg attgcactaa gctgtgccag
     9421 ccagtccggc gactgcggct gaccattttc aaataaggcg gtcagctcag cctggctttt
     9481 ctgcaatgtc tgcagatatt gctgctccgc actcatttgc gtttttgact gacaaccagc
     9541 aagcagactg agtatcaaaa tcagaagtaa tcctcgtttt ccctgcatat cggtctcctt
     9601 ttgggcataa taaaagcgcc tatgagaaaa tcataggcag aaagagaaat gaattgttct
     9661 gaccttcagt gaatgagagc ggacttttgc gcatttgcac cgatgatcaa ttccctgttc
     9721 tttcccctgt tgttgaaaat tccctgatta gtcttcttcc ggctgatacc agccccattg
     9781 tgaaattgtc agcttgctga tggctgccat tgctaaaacg agcatcgccg cagttttcca
     9841 gaaacgctgt ctcatgcttt tctccccttt ctttccattt gataatttta ttatagaaaa
     9901 ttttacggaa atgtctttag tttgggaacc aataggcagt ttttgggagc gaatagacat
     9961 atttcgacaa atttaaggct tagcagaaaa aaagacagtt tcactgcact gtcttctgag
    10021 ccaaagctaa agatatggcg ctggcagtta gggagcaggc aataatccgc cccattccct
    10081 gattgattgc cagcagttca atcactgaga aaataccgca gatactggtt aatatccgac
    10141 ttaaccgtcg ggctcgctga cgatcctgct cggttttgcg gcgtttgtag cgcatgtcag
    10201 gagcccattt ccaaatgatg cccagggata agagatcaag caggacataa attccaggat
    10261 tagggatgaa ctgtgtgagg gcaatgcatc cgaaacaaac gctgtgggtc acaagcagac
    10321 aatgggaaaa gcggtgcaga tggattccac cggtaaagga acggactgcc atcagactga
    10381 gcataaaaac cagcatttcc tgaacacagt tgaagaccaa ggcaataccg gtcatgcaca
    10441 ggatcagaat tccttgaatt aataaattct cgatgccaaa gcgcagatca ttctcattca
    10501 cgggttcgtt cagctgtccg ttgagccagc ggcccagctt taaagaaaaa ttacgcatgt
    10561 ttttcctcct tcggcagtaa aatccggact tcaaaacggt ctgaagccaa gtgaaaatca
    10621 agctcgcctt cagcctgctt cacaatcgtg cggatactct caattccata accatgttct
    10681 tcccaatctg actttgaact tcgttttaga ttgatgcgta gattcggctt aaccgaattg
    10741 atcaacgtca gataaattgt cgtttcatct tctttaagat agagtttaat ttctttctgc
    10801 tgtgacagct ttgcggcttc cacagcattg ctcagcagat tggaaattaa aatacaggta
    10861 tcgacttcct ttaacgacca ttgtacgcgg ccggtttcca gatgaaactg aagatggggc
    10921 tcactctcta tcgttcgatt taagagactg tcaatgattg gatctccggt atgttccttc
    10981 cttgagatat cctctaccgt tttcatagtt gatcgaatgt attcaagagc ttccaggctg
    11041 cgttcctgtg ataaatataa ttcaagcagc cccagcaaat gtttcagatc atgacgctgc
    11101 ttacggtact tctcctgatt ttccaaggtc tccgcaagcc aaactgcttt cagcgtattg
    11161 caattatgtt caatctcaag ccgtttctta ctttcccgca tttgacgata ttgcaaaaac
    11221 acccaattca tcagcacaaa gaatccaaat aaagctgcgc tgagcgcggc cgagagaatc
    11281 cgaatccgcc ggtcattgaa ggtgcagcag atcagataat taaagaacac gcagagaaac
    11341 aataaaagac agctaaaccg aaacatccag cttaaatttt catatcggag caattccggt
    11401 ttcttcttca tcaggacaat cggcgtcaaa atcgccagtt tattaaaata accacccagc
    11461 gttcgcagcc agttctcctg catcaagact tcgatcggga ttttggcacc cagcgttaaa
    11521 acctgaaacg aaatcactga gaggattcct tctgcgatgt aaaacaacaa aactaaaatt
    11581 cccaggttca tggttttccc tgtgaagact aagcgaatca tgatcatcat attcaaaaac
    11641 atcagaagaa ctagtaaagt tggatcagcc atccaaaatt ccatcgaata ttcaacagcg
    11701 gcaaatccca gcagggacaa aagcaggact ggaagggaaa cccgcagggc aaaaaatttc
    11761 tgcactaata gggtgacact gagcatttca agcaggcaaa aactgaattc gatcacaaat
    11821 gcattcatac catcacctta taatctgaaa agcgccgaag aacctctgcc ttctgatact
    11881 tgctgatcat taaaggctga ctcagtccgc ggataaacaa ggtattggct ttgatttttt
    11941 ccacattcat taggttcacg acttccgatc gattaatctg aaccaaatat tcacgcattg
    12001 ccagcacaca gacagcatcg tttaaaacac gtccgcgcaa ttcatatttt atcccgccct
    12061 gcaatgtcag tgttaccttg cggttaaaac agctgagcat taaaatctga tcgcggcgaa
    12121 ttgagatttt gccttgtgtc gtttccactg tcacctgacg ataggcaatt tcctcgttga
    12181 ttttaatgat cattcccgcc agctgttcct ggagttttga cttgacaaga aagccgatca
    12241 catgaaaacc gaacgcttcc gccatatagt gttcctcggc tgtaacataa acaatcaagg
    12301 gggaaactgg ctgttcccgc aaagctttcg ccacagaaaa accattaata ttcggcattt
    12361 caatgtccaa gaataaaaca tcagaagcaa tttgaccgag tgtggcgatc aatttctgcg
    12421 gatcattata cgtcttaatt tcaccaaata gctgagtctt ttccagttcg cctgacatca
    12481 tttcaagaaa ttccagatca tcatctacaa ttgctgcttt tatcatgatt aacgcctccc
    12541 ttaggtcgtc atactccatc cttatttata acacaaacgc tgagcgacta caaaaaaagc
    12601 cgggctgtca aaatgtgaaa tccaacagcc cagcctaagc cttcattcta ttcttccact
    12661 gtgactaaca gagatgactc cacgcgcagt tcactgccgc tgcacaatcc aatataggcc
    12721 ttgcccggct tcactgcggt gacctgacct tgttcatcaa caactgcgac ccgttcatcc
    12781 gaggaaaacc aatgcagtgt gacatcgctt gccgcctccg gcaatctctc acccgtcacc
    12841 gttgtctttt ctccggcttt caaagctgca gcttccgtct tcaggaaaat gttttctgtc
    12901 ggcaccgctt cccgaatctg aacgtcatcc agccacaatg tcccttcagc accgctcagc
    12961 ctgaagctga gatccaatga gtccgcagaa taggctgtga caaagtttaa actgtaaacc
    13021 gcccactcct cgctcatgca cagattatcg ttgagtgtaa cctgatgcgt tgaaatggat
    13081 tcgccgttag ccgtcttctg cgtcatttca atcgtgaagt cagtgctgct cagctgctgc
    13141 gctctgtgat cgaaaacaag ctgatatgtt gtattcggct tcaccgcggc agaggtgctc
    13201 agaactccat caatgcctga tctgattcct gattgggtga gcatcaggga cgaactgccc
    13261 gctgtttttg cagcagtgtc tgcacttaaa acaaatgcag ccgatccgct gtgttcctcc
    13321 gcctgcacta ccgtccagtt ccagccttcc ggctgattcc cattccaaac ttcaaaactg
    13381 ccctgcggca aacgattggc agaatcaatc tgcggtgaca atggatcccc aaaaatctga
    13441 atttcagtga tttcataacc ttggttcgcg gcctttttcc ccgacagctc caagcggaca
    13501 aacttgactg gctggttatt caccgcaatg gcatcgctgt ctttcacatc ctgaatttca
    13561 gcaagagttt gatagctttc gccgtccaga gagccggaaa ctagatactg tttggctttc
    13621 actgtatccc acagcacatg gatctgatca actgcgtaca cccgatccag ttcaatcgta
    13681 atgaattgct gatccgcagc atcggacacc cacggtgttt tcgtgtcata gtccacaagc
    13741 aaatacggag agatttcttc attcaaagaa gaaacgatga cattttgccc cagcgcccga
    13801 ttgtcagaat tggcaaggcc ttccacttca cccagcaatt caaattccgc atagaacaga
    13861 tcatgatcag acagatcact ttcaacccgc tgaatatctg tgatccgcat attctttgta
    13921 cataagacat tgtctatcgt aaaaacattc atggacggat catccgcttc ccgataggta
    13981 tcataccaca tggacttata tccattcgct acgttgaagt tatccagaaa catcgaatat
    14041 tcatattcat gctgatcggt attgaaatct ccggtaatca ctttgtactc catcggatca
    14101 gcattgaccc gctgaatgac ctgtgcaatc tgacggcggc gcagatcaag attttcccag
    14161 cttagatgcg tattgtataa cgcgatctgg actccgtctt tctcgatgac cacccgttcc
    14221 aacgtctttg ttgcccgact gccggtactt tctaacggaa tggaactaac ctgcagcagc
    14281 tcgtgctgac tcacgatgcc aattccaaag gccccatccg caaaatcccg acctttggca
    14341 aaatgaacgt aaggaacgtc atcattcaca aaagcctgag ccagatcctg tgaattccgg
    14401 ttgttctgca catccacttc ctgaattcca acagcgtcaa gacggtgctt ggccagcaca
    14461 gccgccatgg cctgcggatc cggatgtttt tgggaagcga tgttccatgt tccaatccgc
    14521 agcgttacag gaccgctgcc cgaagatgaa tccggtaccg ggctgcagcc tgtgatcatg
    14581 ccaaggacag caaagctgat tagtattttt tttaacttat tcatacattc ctccgggtat
    14641 tcttttgatt gagatttcat ttttcttaac tatagtgtac ccatgttccg cggtcttgtc
    14701 catgtatgat ttctttctat aagttgattt tcatgatcca taaattcatc ttatgatata
    14761 ataaaaccag aatcgaggga tagtatgctg gattatcgcc taaagacctt tctgcttctc
    14821 agcaaaacgc tgaattacac gaaaacagcc cagcagctgc atatgagcca acccgccgtt
    14881 tcgcagcata tccgctacct ggaacaaacc tacaacatca agctgtttga gtattataat
    14941 cgccggctgc agctgacgga aatgggacag cggttttatc agcaggttct ggcgctggaa
    15001 gtgcagagtc aggatatcat cgaacggctg cggcaggaac aggaaaaccg tcgtttactg
    15061 cggtttgact gtaccttcac ttttggcgaa tacatcatgc cgccactgat ctgccggtgg
    15121 atgaaagaaa atccaaacac cgagctgtgc atgcggattc tgggaactgc cgcttgcctg
    15181 gaagcgctgg atcagggaga aattgatttc gctttggttg agggattctt tgataaagcg
    15241 gtctatgaaa gccggctggt gaaaatgacc cacatgggtc tggttgttcc cgtaggccat
    15301 ccgctgacgc agaaaaaaga ggttatgctg aatgacctga ttgcttatcc gctggttgtg
    15361 cgtcaaaagg aatcgcggat gcgcggaatt ctgccgactg ggttggctga acacaattta
    15421 tcctatgaga gctttgccgg aatggttcag tgcggaagca tgaatgtcat gaagacgttg
    15481 attaaaaatg gatgcggaat cggttttctg catgaagata tcattcatgc tgatctggtt
    15541 gaaggaaccc tggtggaaat tccggttgtc gattttgttt tgaagcggga gctgaacatg
    15601 gtttacctgc cgcatcatca agatccggcg ctattagatc agatctatca ggatttgtgt
    15661 gaacatctgc ggcagctggg gacagattaa tccgccttct aagcagaaat catagaagac
    15721 ggatgatgga ttatttatgc gtaaaattct atttctattc ttgtttatgt tgtgattggg
    15781 cagatgttct ttaagcagaa cgatgtgtca tccgcttcgc ttgatcccaa aacgaagaga
    15841 tttccttacg tgtgtcatca agggtattat acctttccag cctctgcggc tgatgcaatg
    15901 gatatacgca caggatggtt cgcgaaagat tgccgaaacc ttcttcttac ggacaacgaa
    15961 agcctgagaa tacgatcatc accgaaacat agtcaatgaa tttaatcaac gccggcttca
    16021 acaatcagcc atagaaattc atacgcttta agatccaatg tttcctgact gccgctgatc
    16081 cggcggcctg tcagcagctc ccgcgcctgt tcttccttat taaacaagga tgtcagcggg
    16141 caatactgcg gagattccgt aaagttgaac aaaaacagaa gccgctgctt tttacaggat
    16201 cggctccata ccaacaaagc atcattgccc gtatccagaa tctgttcctg tccgcagttc
    16261 cagtccggat aatctgaacg gacctgaagc atggctttta aactttggaa tatccggtat
    16321 tccaagctca gcagctgaaa gcgctgctgg gctttttctt cgatataaac cggtctttgc
    16381 agccatcgtc gatcttgttc tttgtctgga tccaggcgga agctgacatc attcagcgcg
    16441 cccagttcat cgccatctga caacagcggc attccccgca tcgccagact taatccctga
    16501 agcagcagca cacgccggca gctgttctcc aattcgtaag gctcatgatg atccatcgcc
    16561 cggccgcatc cagcccagct tgccaaggtt ccgtaacagc gcccgctttc cggatcgctt
    16621 tccccttcgg caaagctgcc caaagcctgt ccggtataga aatccgtcaa aaactgccga
    16681 tgcgactccg gattccatcc gcgcatcatc gccgcttcct cattaaaatt ccagcggagg
    16741 ccctgatcgc agcccaccgg gtgaatcgcg atcgtggctg gggtcagcgc atgaaaaaat
    16801 cagatcggcc cgctgcattt tcgtatcgcg ggtcgccagc gaattccagc tgttgatcat
    16861 ggcggcttga tcgaggacgg atgcggactg cggagcacgc tgggccagaa tttgtaagtc
    16921 atgagctgct gcttcgctgt gaccgatcac cagcacggat gggcatacca gctttccagc
    16981 cgcaacaaaa agcgcaaaca ggtctggaat ctgcggataa agcggctgag ctttgcattc
    17041 tttccacata tgatccagct gccgcagctc aatcgcatcc acacctaaat ccgcaagcga
    17101 acaaaagcgt ttcagcatca cgctcagcac ctgaggattt ttataatcca acagccatcc
    17161 gccagtctgc gggctgcggt agacatattg atgaatcttt tccagcttat aaaatacacc
    17221 ggtttcattt tctttggaaa acggactgta taaagaggca agcttagcat cagcaatcat
    17281 ccaataccgc tgctgcatcg aaagatcccc ttttagcgcc tggcttgccc aaggatcgtc
    17341 ctgcggagtt ccagccacgt caaaatctat gcccaccgca aagccttccg catgccacgc
    17401 gtcaatctcg gtttgaagga cttgccgtga acgttgcgta tgcggaaaag ggacctcgct
    17461 gagctgtacc cagccgatcc ctaactcccg cagttcctta gcccgcaggg atatctgcgc
    17521 tgcagactgc gcggcagaat aattcagccg catgcctgcc ggcgccgagc agaaccaagc
    17581 tgggccgcgg tctttcccgc gatgaagcag actgcgattg agcctctgtt catccagcat
    17641 tgccaaaagc gcatcgaatg tttcttcctg aacatgaaac ggctgataga tcctaaagaa
    17701 agccgcttcc atttctgcca taagcggctg cagccgctgc aggaattcgc cggcgctcat
    17761 ccctcagctc tccggctgct gatccagcaa agcctgtgct tcttcggttg tgaccaggga
    17821 cggcattccg cccttacgag ttacggacaa agccccggaa gcattcgcca gccgcagcat
    17881 ctgatagaca tcctcaccgc tgagctgttc cagcgttttt tccgatttta ggaaactggc
    17941 cagaaagcag cctaagaaac catcgccagc gccggttgta tccaccaccg ataccgggaa
    18001 agctggagcg ttaatatagt aatcgtgaat taaggcatga ctgccctgac tgccctcggt
    18061 gacgaggatc agcggcgttt tgtatttctt cgcaatctgc cgtgctcctt cttccagcgt
    18121 cttgcagccg gttagaaaaa tcaattcttc ttccgcaact ttgaggatat cgcagaactg
    18181 cagaccatgc cggatttcat gccgggcttc ttcttcactg ttccacagcg gcatcctgag
    18241 attcgggtca aatgaaagca gcttcccttt ctgctgggca tattttatga gttcaaaagt
    18301 cgtaatccgc gccggattgt gagtcattga cactgaacca taatggaaga gttcacactc
    18361 gtcgatcgcc cgcagattga cttcctgact ttcaatcatc gtatctgccc ccggattgcg
    18421 gtaaaagcaa aaggaccgtt cacctttttc atcgagctga acgaaggcca acgttgtttt
    18481 ataacgggaa ttgatcacca tatattccgt gtcaacaccc tcgcccttga gcttttcatt
    18541 caaaaactga ccgaagatat cgtcgccgac ctcgccgata aagcttgcct gtacgccatg
    18601 cttcaccgca gccaccgcca aatttgcggg ggctccgccc ggattgcgtt caaataggat
    18661 atttccattt tcactgacgc ctaccggcgt aaaatcaatc aaggtttcac caaatgagca
    18721 tattttcatc tttagttcct cctgcctaag attttgagtc tttcctatct tattctaaca
    18781 cgaaccgaac ttttcccaaa ccctaatcgc aagcgttttc atcttctttt tctttgctga
    18841 cttcctgttt tccatataaa aataatcatc cttattcgtt atagccaaca ggagaaagcg
    18901 acggaataaa ggtttttact cgatttcggg cagggataaa atttccatac aaaaagcagg
    18961 cagaatgaag cagtatataa aactttatcc tgccctatct ctaattctag aacgggcaat
    19021 gcttcaaatc aaaaaggtgc ttcgcttgga aacacctttt taatttactg aatctgactt
    19081 ttgagatagc tgaagatgaa cccgtccaga tcgccatcca tgacattctg aacactaccc
    19141 atttcatagc cggtacgatg atccttgacc atggtatacg gacagaagac atacgaacgg
    19201 atctgcgatc cccattcaat gtttttctgt tcgccgcgga tcgctgccag cttggcttcc
    19261 tgttcctcga tcatccgctg atacagcttg gatttcagca tgttcatgca gcgttcccgg
    19321 ttctgaatct gactgcgctc agtctggcag gataccacaa tgccggtcgg cttgtgcgtc
    19381 atgcgcacag cgctgtcggt cttgttgata tgctgtccgc cggctccgct ggcccgcatc
    19441 gttacgacgt ccagatcttt ttcatcaatc gtaatttcaa tttcatccgc gaactgcggc
    19501 atcacgtcca gggaagcaaa cgaggtgtgc cgacggccgg aggaatcaaa cggagaaatc
    19561 cgcaccagcc ggtgcacgcc cttttccgct ttcagataac cgtaggccat atcgccctcg
    19621 atcagaatgc tcgccgattt aatcccggct tcttcgcctt cctgatagtc cagcaaggta
    19681 accttatagc ccttccgttc agcccagcgg caatacatcc gataaagcat gcttgcccag
    19741 tcctgacttt ccgtgccgcc ggctcccgga tgcagctcca gaatcgcgtt gtttttgtca
    19801 taaggatgcg aaagcagcac catgacttca aactcttcaa actgactgag cgtatcctga
    19861 tattccatat ccagcagctc tttcagttcc tcatcaaaat tctggttcag ctcatccacg
    19921 gtttcctgca atgaggctaa agcctgttcc atctgatgat atttagcttc caactctttc
    19981 atgccgttgc attggcgaat gacattctga gccgctttcg gatcgtccca gaaatgttct
    20041 tcgttcatct tcgcttccag ttcttcaatt tgtttttgct ttgcagctaa gtcaaagaga
    20101 gtcgcctaac tgctttaact tcgttaccga agcggttagg ccttgtcgaa tctcatacag
    20161 ttccatcgtt atttcttacg ctcctctatt acaattctta cattcaggca gaaagtgaca
    20221 acttcctgcg caattcgtgc catcatgtct tcaaacagct gatagccttc ggaaacatac
    20281 gcctgcagcg ggttggactg ggcataggat cgcagatgaa taccgtcgcg cagcttgctc
    20341 atggtatcga tatgatccac ccagttgcgg tcgataactt ttaacaccat cgtcttttct
    20401 atcggcagga catgcacctt gatcggttca atcttgcctt catagacatc ccaagccgct
    20461 ttgcagcaca gctcgctgat ctccggaata ctcttgcctt ccagatccgt ttccgtcaga
    20521 ctttcatgga agcccatctt gcctaacgat tccagcag
//
