LOCUS       c00004_NZ_CCDM..       10387 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  NZ_CCDM010000004.1 Oceanobacillus jeddahense strain S5, whole genome
            shotgun sequence.
ACCESSION   NZ_CCDM010000004
VERSION     NZ_CCDM010000004
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 6.1.1
            Run date     :: 2024-03-14 16:03:26
            Original ID  :: NZ_CCDM010000004.1
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 121253
            Orig. end    :: 131640
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..10387
                     /aStool="rule-based-clusters"
                     /category="other"
                     /contig_edge="False"
                     /core_location="[126253:126640](+)"
                     /cutoff="20000"
                     /detection_rule="ectoine_synt"
                     /neighbourhood="5000"
                     /product="ectoine"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      5001..5387
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="ectoine_synt"
                     /neighbourhood="5000"
                     /product="ectoine"
                     /protocluster_number="1"
     cand_cluster    1..10387
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="ectoine_synt"
                     /kind="single"
                     /product="ectoine"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..10387
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="ectoine"
                     /region_number="1"
                     /rules="ectoine_synt"
                     /tool="antismash"
     CDS             1388..1570
                     /locus_tag="ctg4_115"
                     /transl_table=11
                     /translation="MDNNNRNFNRNERRNRNNENQRNQEIDNVEFANENEFVDENTFKD
                     NNNRNNERRNNRNRK"
     CDS             2075..2803
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1235:polysaccharide deacetylase (Score: 108.7;
                     E-value: 5.7e-33)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg4_116"
                     /transl_table=11
                     /translation="MKKKILYTITFLLLTSCFFFIIHEEIHAKNRFDFEKDGDIFWDAK
                     TEEKVIALTFDDGPHSKYTPAVLNILSEYGAKATFFVLGAHAEKFPDIIYRQVMEGHEI
                     GNHTYDHTTKLSRLSQEMKETSDIIYAITGNRPKLFRPVGGEYNNAIVRKAKENQLHPV
                     LWSWDQDTKDWNDTDYKTIADNVIRNVSPGDVILFHDAGGNREETVKALPLILDYLAEH
                     EYETITVSEMMKKDERITEN"
     PFAM_domain     2207..2554
                     /aSDomain="Polysacc_deac_1"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF01522.23"
                     /description="Polysaccharide deacetylase"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg4_116_0001"
                     /evalue="4.00E-32"
                     /label="ctg4_116"
                     /locus_tag="ctg4_116"
                     /protein_end="160"
                     /protein_start="44"
                     /score="110.9"
                     /tool="antismash"
                     /translation="KTEEKVIALTFDDGPHSKYTPAVLNILSEYGAKATFFVLGAHAEK
                     FPDIIYRQVMEGHEIGNHTYDHTTKLSRLSQEMKETSDIIYAITGNRPKLFRPVGGEYN
                     NAIVRKAKENQL"
     CDS             3150..3674
                     /locus_tag="ctg4_117"
                     /transl_table=11
                     /translation="MTLTIEKENDFYFREPAKDDGAAVWELIKDTKVLDLNSSYSYLMW
                     CDIFSETSIVAEKNGKTLGFISGYKNPNNTNKLFIWQVAVDASARGNGLATKMLRQLLK
                     REACKEINYVEATVSPSNQPSQSLFKGLAKKLDTDCHISDYYVTEDFPDEEEEHEDELL
                     FTIGPIATENK"
     aSDomain        3186..3656
                     /aSDomain="TIGR02406"
                     /aSTool="tigrfam"
                     /description="ectoine_EctA: diaminobutyrate
                     acetyltransferase"
                     /detection="hmmscan"
                     /domain_id="TIGRFam_ctg4_117_0001"
                     /evalue="8.60E-59"
                     /identifier="TIGR02406"
                     /label="ctg4_117"
                     /locus_tag="ctg4_117"
                     /protein_end="169"
                     /protein_start="12"
                     /score="196.0"
                     /tool="antismash"
                     /translation="FREPAKDDGAAVWELIKDTKVLDLNSSYSYLMWCDIFSETSIVAE
                     KNGKTLGFISGYKNPNNTNKLFIWQVAVDASARGNGLATKMLRQLLKREACKEINYVEA
                     TVSPSNQPSQSLFKGLAKKLDTDCHISDYYVTEDFPDEEEEHEDELLFTIGPI"
     PFAM_domain     3258..3539
                     /aSDomain="Acetyltransf_1"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00583.27"
                     /description="Acetyltransferase (GNAT) family"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg4_117_0002"
                     /evalue="7.70E-16"
                     /label="ctg4_117"
                     /locus_tag="ctg4_117"
                     /protein_end="130"
                     /protein_start="36"
                     /score="58.5"
                     /tool="antismash"
                     /translation="NSSYSYLMWCDIFSETSIVAEKNGKTLGFISGYKNPNNTNKLFIW
                     QVAVDASARGNGLATKMLRQLLKREACKEINYVEATVSPSNQPSQSLFK"
     CDS             3692..4969
                     /NRPS_PKS="Domain: Aminotran_3 (31-366). E-value: 2e-79.
                     Score: 258.9. Matches aSDomain:
                     nrpspksdomains_ctg4_118_Aminotran_3.1"
                     /NRPS_PKS="type: other"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Aminotran_3"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1013:aminotransferase class-III (Score: 381.8;
                     E-value: 6.2e-116)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg4_118"
                     /sec_met_domain="Aminotran_3 (E-value: 4.3e-82, bitscore:
                     270.5, seeds: 13, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="LTTATWNDAKMKTFENLESEVRSYSRGWPTVFEKSKGYKLWDTDG
                     KEYIDFFAGAGTLNYGHNDDAMQEKLIEYIKNDGVIHSLDMATIPRQDFLERFNEVILK
                     PRNLDYKIMFPGPTGTNTVESALKIARKITGRETVISFTNAFHGMTIGSLSVTGNSFKR
                     HGAGVPLHHAVSMPFDNYVEDNDSIAYLDRFLEDSGSGVALPAAIILETVQGEGGINAA
                     RMEWLKKVEALCRRWDILLIVDDVQAGNGRTGTFFSFEPAGIKPDVVCLSKSIGGIGLP
                     MAITLIKSEYDQWGPGEHNGTFRGNNMAFLAATEALKNWENDNFANAVQEKGVFLKSEI
                     NRLIDQYPELNGEARGRGLMQGIAVEKEALAGEICAEAFNRGLIVETSGPDDEVVKFLP
                     PLIIDQEGLEKGIDILEDSIKHVLKK"
     aSDomain        3722..4963
                     /aSDomain="TIGR00709"
                     /aSTool="tigrfam"
                     /description="dat: 2,4-diaminobutyrate 4-transaminase"
                     /detection="hmmscan"
                     /domain_id="TIGRFam_ctg4_118_0003"
                     /evalue="1.30E-163"
                     /identifier="TIGR00709"
                     /label="ctg4_118"
                     /locus_tag="ctg4_118"
                     /protein_end="424"
                     /protein_start="10"
                     /score="542.7"
                     /tool="antismash"
                     /translation="MKTFENLESEVRSYSRGWPTVFEKSKGYKLWDTDGKEYIDFFAGA
                     GTLNYGHNDDAMQEKLIEYIKNDGVIHSLDMATIPRQDFLERFNEVILKPRNLDYKIMF
                     PGPTGTNTVESALKIARKITGRETVISFTNAFHGMTIGSLSVTGNSFKRHGAGVPLHHA
                     VSMPFDNYVEDNDSIAYLDRFLEDSGSGVALPAAIILETVQGEGGINAARMEWLKKVEA
                     LCRRWDILLIVDDVQAGNGRTGTFFSFEPAGIKPDVVCLSKSIGGIGLPMAITLIKSEY
                     DQWGPGEHNGTFRGNNMAFLAATEALKNWENDNFANAVQEKGVFLKSEINRLIDQYPEL
                     NGEARGRGLMQGIAVEKEALAGEICAEAFNRGLIVETSGPDDEVVKFLPPLIIDQEGLE
                     KGIDILEDSIKHVLK"
     aSDomain        3728..4951
                     /aSDomain="TIGR02407"
                     /aSTool="tigrfam"
                     /description="ectoine_ectB: diaminobutyrate--2-oxoglutarate
                     aminotransferase"
                     /detection="hmmscan"
                     /domain_id="TIGRFam_ctg4_118_0002"
                     /evalue="2.10E-207"
                     /identifier="TIGR02407"
                     /label="ctg4_118"
                     /locus_tag="ctg4_118"
                     /protein_end="420"
                     /protein_start="12"
                     /score="686.6"
                     /tool="antismash"
                     /translation="TFENLESEVRSYSRGWPTVFEKSKGYKLWDTDGKEYIDFFAGAGT
                     LNYGHNDDAMQEKLIEYIKNDGVIHSLDMATIPRQDFLERFNEVILKPRNLDYKIMFPG
                     PTGTNTVESALKIARKITGRETVISFTNAFHGMTIGSLSVTGNSFKRHGAGVPLHHAVS
                     MPFDNYVEDNDSIAYLDRFLEDSGSGVALPAAIILETVQGEGGINAARMEWLKKVEALC
                     RRWDILLIVDDVQAGNGRTGTFFSFEPAGIKPDVVCLSKSIGGIGLPMAITLIKSEYDQ
                     WGPGEHNGTFRGNNMAFLAATEALKNWENDNFANAVQEKGVFLKSEINRLIDQYPELNG
                     EARGRGLMQGIAVEKEALAGEICAEAFNRGLIVETSGPDDEVVKFLPPLIIDQEGLEKG
                     IDILEDSIK"
     PFAM_domain     3779..4945
                     /aSDomain="Aminotran_3"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00202.23"
                     /description="Aminotransferase class-III"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg4_118_0003"
                     /evalue="2.10E-80"
                     /label="ctg4_118"
                     /locus_tag="ctg4_118"
                     /protein_end="418"
                     /protein_start="29"
                     /score="270.5"
                     /tool="antismash"
                     /translation="TVFEKSKGYKLWDTDGKEYIDFFAGAGTLNYGHNDDAMQEKLIEY
                     IKNDGVIHSLDMATIPRQDFLERFNEVILKPRNLDYKIMFPGPTGTNTVESALKIARKI
                     TGRETVISFTNAFHGMTIGSLSVTGNSFKRHGAGVPLHHAVSMPFDNYVEDNDSIAYLD
                     RFLEDSGSGVALPAAIILETVQGEGGINAARMEWLKKVEALCRRWDILLIVDDVQAGNG
                     RTGTFFSFEPAGIKPDVVCLSKSIGGIGLPMAITLIKSEYDQWGPGEHNGTFRGNNMAF
                     LAATEALKNWENDNFANAVQEKGVFLKSEINRLIDQYPELNGEARGRGLMQGIAVEKEA
                     LAGEICAEAFNRGLIVETSGPDDEVVKFLPPLIIDQEGLEKGIDILEDS"
     aSDomain        3785..4789
                     /aSDomain="Aminotran_3"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg4_118_Aminotran_3.1"
                     /evalue="2.00E-79"
                     /label="ctg4_118_Aminotran_3.1"
                     /locus_tag="ctg4_118"
                     /protein_end="366"
                     /protein_start="31"
                     /score="258.9"
                     /tool="antismash"
                     /translation="FEKSKGYKLWDTDGKEYIDFFAGAGTLNYGHNDDAMQEKLIEYIK
                     NDGVIHSLDMATIPRQDFLERFNEVILKPRNLDYKIMFPGPTGTNTVESALKIARKITG
                     RETVISFTNAFHGMTIGSLSVTGNSFKRHGAGVPLHHAVSMPFDNYVEDNDSIAYLDRF
                     LEDSGSGVALPAAIILETVQGEGGINAARMEWLKKVEALCRRWDILLIVDDVQAGNGRT
                     GTFFSFEPAGIKPDVVCLSKSIGGIGLPMAITLIKSEYDQWGPGEHNGTFRGNNMAFLA
                     ATEALKNWENDNFANAVQEKGVFLKSEINRLIDQYPELNGEARGRGLMQGIAVE"
     PFAM_domain     5001..5375
                     /aSDomain="Ectoine_synth"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF06339.14"
                     /description="Ectoine synthase"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg4_119_0004"
                     /evalue="6.30E-59"
                     /label="ctg4_119"
                     /locus_tag="ctg4_119"
                     /protein_end="125"
                     /protein_start="0"
                     /score="197.9"
                     /tool="antismash"
                     /translation="MIVKSLEDLVGTEDETKSENWESRRFILKKDGVGFSMNDTIIKAG
                     TDNFFWYKNHIEAVYCIEGEGEVEKVSTGDVYQLKPGTMYLLDENDKHRLRARTQMRMV
                     CVFNPPLVGTETHNEEGYYPL"
     CDS             5001..5387
                     /gene_functions="biosynthetic (rule-based-clusters)
                     ectoine: ectoine_synt"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg4_119"
                     /sec_met_domain="ectoine_synt (E-value: 7.9e-53, bitscore:
                     172.3, seeds: 10, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIVKSLEDLVGTEDETKSENWESRRFILKKDGVGFSMNDTIIKAG
                     TDNFFWYKNHIEAVYCIEGEGEVEKVSTGDVYQLKPGTMYLLDENDKHRLRARTQMRMV
                     CVFNPPLVGTETHNEEGYYPLLTE"
     CDS             complement(6093..6527)
                     /locus_tag="ctg4_120"
                     /transl_table=11
                     /translation="MQWKKPGSEDYPALIELWEKSVLATHDFLASEDRESLKKGIPAYF
                     PQLDMKMWFEDTTFIGFSGVNASQLEMLFLDPEQIRKGFGSRILNDLIEKDGIKLVDVN
                     KDNKPALAFYLKNNFQITGESEQDDQGRDYPILHLGLKAE"
     PFAM_domain     complement(6171..6371)
                     /aSDomain="Acetyltransf_1"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00583.27"
                     /description="Acetyltransferase (GNAT) family"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg4_120_0005"
                     /evalue="1.70E-05"
                     /label="ctg4_120"
                     /locus_tag="ctg4_120"
                     /protein_end="119"
                     /protein_start="52"
                     /score="25.1"
                     /tool="antismash"
                     /translation="WFEDTTFIGFSGVNASQLEMLFLDPEQIRKGFGSRILNDLIEKDG
                     IKLVDVNKDNKPALAFYLKNNF"
     CDS             complement(6595..8118)
                     /locus_tag="ctg4_121"
                     /transl_table=11
                     /translation="MEHMGWLSLIPPVLAVILAILTKNVIISLFLGAFVGVLIIVGGNP
                     LTATTETIGNFLFPQLTDSYNAAVLVLLFFIGGFVALIEKSGGGAALAAKTVKSINSKV
                     KAQLSAWFGGLIIFFSDLGTPLIVGPIFEKIFDKARISREKLAYIIDSTSSPVAVLIPF
                     IGWGVYIMGLIRSEFDALGITTSEFDTFVQVIPFQFYAISAVLMIPLMTLFKLDFGPMA
                     KAERRVRETGELYWKDSKPLRRPDKEAEDNQESKAILIWLPLLVLFVTLFGLLSTKGFP
                     FEPVDGNDFRVSLTTAYLFAAITIFILLIGFRMKKFAEIFDIYTSGMQKMVYVAATLVL
                     AWSLGTVISEMGTANYIVELMQGRVPAFIIPALLFIIGAIVSLASGSSWGTFAIMLPIA
                     IPMAVALDAQLLVCIGAVLSGGIFGDHSSPISDTSILSSTGAGADHIDHVKTQFPYALT
                     NAIIAVIGFVVAGLTGSPWTVILTIVLLILAAFVLSKLTKNKYESKMNV"
     PFAM_domain     complement(6703..7650)
                     /aSDomain="Na_H_antiporter"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF03553.16"
                     /description="Na+/H+ antiporter family"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg4_121_0006"
                     /evalue="6.10E-71"
                     /label="ctg4_121"
                     /locus_tag="ctg4_121"
                     /protein_end="472"
                     /protein_start="156"
                     /score="239.2"
                     /tool="antismash"
                     /translation="VAVLIPFIGWGVYIMGLIRSEFDALGITTSEFDTFVQVIPFQFYA
                     ISAVLMIPLMTLFKLDFGPMAKAERRVRETGELYWKDSKPLRRPDKEAEDNQESKAILI
                     WLPLLVLFVTLFGLLSTKGFPFEPVDGNDFRVSLTTAYLFAAITIFILLIGFRMKKFAE
                     IFDIYTSGMQKMVYVAATLVLAWSLGTVISEMGTANYIVELMQGRVPAFIIPALLFIIG
                     AIVSLASGSSWGTFAIMLPIAIPMAVALDAQLLVCIGAVLSGGIFGDHSSPISDTSILS
                     STGAGADHIDHVKTQFPYALTNAIIAVIGFVVAGL"
     CDS             complement(8478..8711)
                     /locus_tag="ctg4_122"
                     /transl_table=11
                     /translation="MSNNEKRSSKSGKPNRNEERRTMLDEHEEQMFVDDVPLEDLKIEA
                     RDEKRKTKSKDESQSEKKHKEKQNEDKDTKNP"
     PFAM_domain     9058..9210
                     /aSDomain="YfhD"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF14151.8"
                     /description="YfhD-like protein"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg4_123_0007"
                     /evalue="4.40E-18"
                     /label="ctg4_123"
                     /locus_tag="ctg4_123"
                     /protein_end="51"
                     /protein_start="0"
                     /score="65.3"
                     /tool="antismash"
                     /translation="MGRDEHKKRKNNFLSQTPKNQISDGIDVEFSDELADAEDKKAQAR
                     SRASDK"
     CDS             9058..9225
                     /locus_tag="ctg4_123"
                     /transl_table=11
                     /translation="MGRDEHKKRKNNFLSQTPKNQISDGIDVEFSDELADAEDKKAQAR
                     SRASDKTKLH"
     CDS             complement(9222..9692)
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1111:GCN5-related N-acetyltransferase (Score: 84.2;
                     E-value: 1.8e-25)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg4_124"
                     /transl_table=11
                     /translation="LMKLPEVTLRELKLEDAEDRYKWCLDKEVTKYLNIPDTYPPFTME
                     ETKNWIQKCMDKSNGYEQKAILTGNGKHIGWVDLKNIDAFNQQAELGITIGNKDFWRKG
                     YGMAAMEKMLQWGFRELHLHKVWLRVDMDNQRAIKSYKTKRTLSGRRTKTPT"
     PFAM_domain     complement(9276..9674)
                     /aSDomain="Acetyltransf_3"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF13302.9"
                     /description="Acetyltransferase (GNAT) domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg4_124_0008"
                     /evalue="6.70E-25"
                     /label="ctg4_124"
                     /locus_tag="ctg4_124"
                     /protein_end="139"
                     /protein_start="6"
                     /score="88.5"
                     /tool="antismash"
                     /translation="VTLRELKLEDAEDRYKWCLDKEVTKYLNIPDTYPPFTMEETKNWI
                     QKCMDKSNGYEQKAILTGNGKHIGWVDLKNIDAFNQQAELGITIGNKDFWRKGYGMAAM
                     EKMLQWGFRELHLHKVWLRVDMDNQRAIK"
ORIGIN
        1 tctttggcaa tacacgaaac ccatggaata cgctgtatat gccaggtgga tcaagtggcg
       61 gtggaactgc ttccttagct gcaggtctag caatacttgc aactggctca gacacatttg
      121 gatccatacg cttgcccgct tccatgtgcg gtgtgtacgg actaaagaca acttatgggt
      181 tagtcagtac ggatggcatt tttcctacag ctatgtcttt agatactgcc ggccctatgg
      241 caagatctgt ttctgatttg gcattgatgc tttattatat ggcaggcttc gatgtaaacg
      301 atcctggaag cttggatgta cctgttccaa attatatgga agatttaaat aaaggaatca
      361 aaggtataaa aattggtatc cctgcttact ttctccaaga ccttgctccg gatgtcgaaa
      421 gtctttttaa acgtgccatg gcaacactcc actatttagg tgctgaaata atcgaggtgg
      481 agattcctga attaagttta tcaacctttt ccggttatac gatagcggca ggagaagcat
      541 ctgctttaca tcataaatgg ctgcagacgc attcaagcga ttattctgca gacatacgaa
      601 gtttctttat ggctggcgca ttaacaaaca caccacaata cattcaagcg caacaagcgc
      661 ggagaaaaat ggttaaaggg tttcagaaag cttttaacca tgttgatata ttgcttggtc
      721 caacaatacc tatcactcct catatttata gcgaacattg ggtagagcaa aacatggaag
      781 ttataagtag atgtctgcca tttactgtac ctgttaattt aaccggtaca ccaagcctgg
      841 ctgttccaat gggattggat agtaatagcc ttccggttgg tatgcagttg attggaaaac
      901 ctctttctga aaaattgtta ttacgggcag gtaaagcttg ggaaagtacc tcgccattac
      961 attttcggat tcagaattaa ggtaaggacc ttcttatttg ccaccattta attttggcaa
     1021 tgttttcgtg atttactttt tgagtatcag ctctgtttaa tcatgactga tttcagcatc
     1081 tgtcataggt acgtcgctga tatcaaaaaa accaattttt cttttcattc cgaataacga
     1141 taatttacta tgaccattta aaatgctttt tatcttttgt attaaaaagt ttgacctgcc
     1201 atttcagcaa aatgagaacc ctgctgaccc tttttcaaat aacaaaatat ggctttcgaa
     1261 atagcgagtg attttttaat aaaggggtaa aatattattc gaggacggca tttgtattgg
     1321 aaatacctgc ttcacaacat ttccaaaata aatgtttacc tcatacagaa tattgggagg
     1381 gttttcaatg gacaacaata atcgtaattt caaccgcaat gaacgaagaa atcgcaataa
     1441 cgagaaccaa cgtaatcaag aaatagataa cgtggaattt gcaaatgaga atgaatttgt
     1501 tgacgaaaac acttttaaag acaacaataa ccgcaacaac gagcgacgca ataaccgtaa
     1561 tcgcaaatag gtaaccatta tttttaaaga tacctgaatc aatggatgaa aaattcctga
     1621 ttcaggtatc ttttttatga ttaaattttg tgtcattaaa ccaaacttga tccttttcgt
     1681 aattgttttt ttgcagatgt tcctcctctc caaaattttc atgtgttcat gtatgataaa
     1741 aaagccttca ccagcaaata atagagatag aacatagcca atttcattta taaaacgaaa
     1801 cttcactcag tgggagtttt cgacgcacag ctctttacga tgggacgagt aatcgcagtc
     1861 ccagtgccag ctccagtccc aggacgtcgc gaacgtagtc tgctgctttt ctcccactga
     1921 gttagcctaa gtgattcagg gagttagctc acctaatctc ccgcctaaat aagtttattt
     1981 tcacgcttta ttttgagacg ggagttttac ggacggttct ccgtgataaa taatacgtca
     2041 tgtttcattg acttttgaga attagaggtg ccaaatgaag aaaaaaatac tttatacgat
     2101 tactttcctg cttctgactt cttgtttttt cttcataatc catgaagaga tacatgcaaa
     2161 aaatagattt gattttgaaa aagacggaga tattttctgg gatgcgaaaa cggaagaaaa
     2221 agtaatcgca ttaacatttg atgatggccc acactcaaaa tatactcctg ccgttctgaa
     2281 tattttaagt gaatacggag ccaaagctac tttttttgta ctgggcgccc acgcagaaaa
     2341 atttccggat attatttatc gtcaagtaat ggaaggacac gaaattggta atcacaccta
     2401 tgatcacacc acaaaactca gccggcttag tcaagaaatg aaagaaacct ccgatatcat
     2461 ctacgctatc acaggaaacc ggccaaaact atttcgacct gttggcgggg aatataataa
     2521 tgcgattgtc cgaaaagcta aagaaaatca gttacatcct gttttatggt catgggatca
     2581 agatacaaaa gattggaacg acacggatta taaaacgatt gcagataatg tcatccgtaa
     2641 tgtgtctcct ggggatgtta ttctttttca tgatgcagga gggaatagag aagaaacagt
     2701 aaaagcactt ccacttatcc tcgattatct ggctgaacat gaatatgaaa caattacagt
     2761 atctgaaatg atgaagaagg atgaaagaat aacagaaaat tagcaggata ttctccattc
     2821 caactgttat tcatttcttt cttcacccat cattttaaaa aatctactct gctaatgtaa
     2881 cattttttcc aattgaacat ttggcctcgc ttcacactcc gcttccctgc caatttttct
     2941 aaatctttaa aaacaggctt atttctatta tattcaaagc tattgatagg cagtggcagg
     3001 cattttactc ttatccgctc tcaccataaa taatcgctga atttccggtt ttatgcgttt
     3061 tgacgttatt tttccttatg ttagtctaat atggtaagta aaaaatccac tcaggaggtg
     3121 agagcattaa tacaaacaca acaaatgaca tgacattaac tattgaaaaa gaaaacgatt
     3181 tttattttcg cgaacctgca aaagatgatg gggcagctgt ttgggaactg attaaagata
     3241 ccaaggtgct tgatctcaat tcttcctaca gttacttaat gtggtgtgat attttttcag
     3301 agacctccat cgttgcagaa aaaaacggga aaacacttgg ttttatttcc gggtataaaa
     3361 atccgaataa tacgaataaa ctatttatct ggcaagttgc tgtagatgct tccgctcgag
     3421 gtaacggatt agcaacaaaa atgctgcgcc aattattaaa gcgcgaagct tgtaaagaga
     3481 ttaattatgt ggaagcaacc gtttccccat ccaatcaacc ttcccaatct ttatttaaag
     3541 gtctcgctaa aaagctggat acggattgtc atatcagtga ctactacgta acggaagatt
     3601 ttccggatga agaggaagaa catgaagatg agttactgtt tacaattgga ccaattgcta
     3661 cagaaaataa ataattaaag gaatgatttc attgacaaca gcaacatgga atgatgcgaa
     3721 aatgaaaacg tttgaaaatt tagaatcaga agtaagaagc tacagcagag gatggccgac
     3781 ggtttttgaa aaatcaaaag gctacaagct ttgggatacg gatggaaaag aatatattga
     3841 tttctttgcg ggtgcaggca cattgaatta tggtcacaat gacgatgcca tgcaagagaa
     3901 attaattgaa tatattaaaa atgatggcgt gattcacagt cttgatatgg ctacaattcc
     3961 aagacaagat ttcctggagc gttttaatga ggtgattctc aagccgcgaa atttggatta
     4021 taaaatcatg ttccctggcc ccactggcac aaacaccgta gaaagtgccc tgaaaatcgc
     4081 cagaaaaata accggacggg aaaccgtaat cagctttacc aatgcgtttc atggaatgac
     4141 gattggttcc ctttctgtga caggaaattc attcaagcga cacggtgcgg gagttccgtt
     4201 acatcatgct gtttcgatgc catttgataa ttatgtggaa gacaatgatt cgattgctta
     4261 tctggaccgc tttttagaag acagcggaag tggtgttgcc ctccctgctg caatcattct
     4321 ggaaaccgtt cagggagaag gcgggattaa cgctgcacgc atggaatggc tgaaaaaagt
     4381 agaagcacta tgcagacgct gggatattct cctgatcgtg gatgatgtac aggctggaaa
     4441 tggacgtacg ggcactttct tcagctttga accggctgga attaaaccgg atgtggtctg
     4501 tctgtctaaa tccattgggg gaattggtct gccgatggcg attacattaa tcaaatcaga
     4561 gtatgaccag tggggacccg gcgagcataa cggaaccttc cgaggcaata atatggcttt
     4621 ccttgctgca accgaagcgc tgaaaaattg ggagaacgat aattttgcca atgccgtaca
     4681 agaaaaaggc gtatttctca aatcagaaat caacagattg atcgaccaat atccagaatt
     4741 aaatggagaa gccagaggca gaggtttaat gcagggcatt gccgttgaaa aagaagcgtt
     4801 agcaggtgaa atttgtgcgg aagcatttaa ccgcggtctt attgtggaaa cctccggccc
     4861 ggatgatgaa gtggtgaaat tcctgccgcc attgattatt gatcaggaag gtctggaaaa
     4921 aggaatagat attctggaag atagtataaa acatgtatta aaaaaataga gatgctgttc
     4981 acggaaagga gaatttataa atgatcgtaa aatcactgga agacttagtt ggaacagaag
     5041 atgaaacaaa atccgaaaat tgggaaagcc gtcgttttat cttaaaaaaa gatggtgtcg
     5101 gcttcagcat gaacgatacc attatcaaag caggaacaga taatttcttc tggtataaaa
     5161 accatattga agcagtttac tgcattgaag gtgaaggtga agtcgaaaag gtttctacgg
     5221 gagatgtata ccagcttaag cctggcacca tgtatctgtt agatgaaaat gataagcacc
     5281 gtctccgggc acgcacacaa atgcgtatgg tctgtgtatt caacccgcct ttagtcggaa
     5341 cggaaacgca taatgaagaa ggatattatc cgcttttaac agaataaatc accttcaaaa
     5401 aatcctctga tcaagggtat cccctatcag aggatttttt ccgctttgac ttgaactact
     5461 ccatcttgat ttcaagcaaa atctgaagat ggagattcct gcgaacacca atgcatccat
     5521 cagttatttt agcaggctct acccgtagtc cctacggtga atgctttgat actttatacg
     5581 acggcttcac cgcacaccct attttagctt ggttttcgca acttcagtgt gtgcgtgtca
     5641 agtagtgctt ggatatttca cgtgacaaag catttcttgt cacaaccctg tatacccagt
     5701 tctcaaagaa tgtttcgtat attgatattg caccacgaga acgtaagttt gtatacaaaa
     5761 aaaagacgat tcatctccac cctagcttcg cttgaggatg gagtcttctc gaccaaaatg
     5821 ataaattcga tgtatggact gagattcgtc cggggttttt gtaagaaaac ttggcattca
     5881 ttaaggatta ctctccccac cgaagtaatt ttgcgattaa tcgtcccatt aaaaacgctg
     5941 ctctttcacc gacatagatt ggttatcgta tccttcataa taaaaagccg tctatttctt
     6001 attacaaaga aacaaacggc ttcatccagc agtcagcttt caaattttat tgtcaaaatt
     6061 tatttaactg cttccatcat ttctcttcta tattattcgg ctttcaaacc caaatgcagg
     6121 atcggatagt ctctcccctg gtcatcctgt tctgactctc cagtaatttg aaagttattt
     6181 ttcagataaa aagcaagagc cggtttatta tctttattga catctactaa cttaatgccg
     6241 tccttttcaa ttaaatcatt taaaattctg ctgccaaacc cctttcttat ttgctccggg
     6301 tctaagaaca acatttctaa ctgagacgca ttcacaccgg aaaatccaat gaatgtagta
     6361 tcttcaaacc acattttcat atctaattgc ggaaaataag caggaattcc tttcttaagc
     6421 gactccctat cctctgatgc taaaaaatca tgtgttgcca aaacagattt ctcccataat
     6481 tcgattaagg cagggtaatc ctcactgcca ggctttttcc attgcattat ttcttcctcc
     6541 gttaaaaaaa tcgaaataaa acatgcctca cttcaccagc aaggcatgtt tcttttatac
     6601 attcattttc gattcatatt tattttttgt caactttgat aatacaaatg ctgctaaaat
     6661 aagcaataca attgtgagta ttacggtcca cggactgcca gtcaaacctg caacaacaaa
     6721 accgattacc gcaatgattg cattggtcaa tgcataaggg aactgtgttt tcacgtgatc
     6781 aatatgatct gcaccagctc ctgttgatga caaaatactt gtatcagata ttggagagct
     6841 atgatctcca aaaatgccgc cggacaatac agcgccgata cagacaagca attgtgcatc
     6901 taatgcaacc gccatcggaa tagcaatcgg aagcataata gcgaatgttc cccaggaaga
     6961 accggaagct agtgaaacaa ttgccccgat aataaagagc aatgctggta taataaatgc
     7021 cggcactctt ccctgcatta attctacgat ataattcgct gttcccatct cactgataac
     7081 cgttccaagc gaccaagcaa gcactagagt cgcagcaaca tagaccatct tttgcatccc
     7141 ggatgtataa atatcaaaaa tctctgcaaa ctttttcatc cggaagccaa ttaataagat
     7201 aaaaatggta atagctgcaa ataaataagc tgttgtcagc gagacgcgga agtcattacc
     7261 atccactggt tcaaacggaa atccttttgt ggaaagcaat ccaaacaatg tcacgaatag
     7321 gaccaataaa ggaagccaaa ttaaaatagc tttgctttct tgattatcct ccgcttcctt
     7381 atccggtctt cgcagcggct tggaatcctt ccagtacagc tcgccggttt ctctaactct
     7441 gcgttccgcc tttgccatcg gaccaaaatc taatttaaag agcgtcatta atggaatcat
     7501 caatactgct gaaatagcgt agaactgaaa tggaatgact tgaacaaagg tatcgaactc
     7561 cgatgtagtt attcccagtg cgtcgaactc acttcttatc agccccataa tatagacgcc
     7621 ccagccaata aaagggatca atacagcaac tggagaagac gtagaatcaa tgatatacgc
     7681 cagtttctct ctagaaattc ttgctttatc aaatattttc tcaaaaatag ggccgacaat
     7741 caaaggcgtc cccaaatcag agaaaaaaat aatcaagccg ccaaaccaag cagataattg
     7801 agctttcact ttagaattaa tcgatttgac agtttttgct gcaagtgcag cgcctccccc
     7861 tgatttttcg attaaagcta caaaccctcc gataaaaaat aacaagacaa gcacagccgc
     7921 attgtagctg tctgtcaatt gcggaaacag aaaatttcct atcgtttccg ttgttgcagt
     7981 taatggattt cctcccacaa taataagtac gcccacaaag gcacctaaaa ataatgaaat
     8041 aataacgttt ttcgtaagaa tcgctagaat cactgccaaa actggcggaa taagcgacag
     8101 ccaccccata tgttccatct tttctctcct tttttcttca tgctttcatg aatgatatac
     8161 agtacatctt tatcagttat tttaatcata ctgttataaa ttgaacataa aaagtcattg
     8221 ttaatcaatg tatgttcctt attttaacac gggaaagaga aaaataaatg aaacaaaata
     8281 cctaataatt atgcatttta acgaataatt atactataac aaacattatt aaacagcctg
     8341 tttattgaaa gaataattaa gccattgcta tgacagcttc taattaatcg cgaaagaaag
     8401 ctgtgtatta catttcaatc cttctctatt aacaagaagt cccttcatat cacaataaaa
     8461 cccctcagca atgacgctca ggggttttta gtatctttgt cttcattttg tttttcttta
     8521 tgcttctttt cactttgtga ctcatccttt gattttgtct ttcgtttctc atccctggcc
     8581 tctatcttta gatcttccaa gggaacgtca tctacaaaca tctgctcctc atgttcatcc
     8641 agcatggtcc tgcgctcttc atttcgattc ggtttcccgc tctttgaaga acgtttttca
     8701 ttgttggaca ttcttatcca cctctctgtc tctttttaat acttttcctt tctaagtgga
     8761 ttactaaaca tcattatgcg aaaatttctg cttgcaccaa ttttaacaac catcatacat
     8821 cacatccaaa aatttaagca gtatagtatg tttcattttg ccattgtaaa caatgaataa
     8881 gtatcgtaaa ccagttaaaa atacaaatat gtcagtacag acttccctta tgttgtctaa
     8941 ggagcagacg atgcaacagc tgccgtcaca aagcagaccg atgtattgcg atttttaacc
     9001 tgtctggcag acgattaact aaccaattat atacaaacct aaaaaggggt gttcccaatg
     9061 ggcagagatg agcataagaa aagaaaaaat aattttttat cacaaactcc taaaaatcag
     9121 atatctgacg gcatcgatgt cgaattttca gatgaattag ctgatgcgga agataaaaaa
     9181 gctcaagcaa gaagccgcgc ttctgataaa acgaaacttc actaagtggg agtttttgtt
     9241 cttctcccac ttagtgttcg tttcgtttta taggatttta ttgctctttg gttatccatg
     9301 tccacccgca accacacttt atgcagatgt aattcccgaa atccccattg tagcatcttc
     9361 tccatcgccg ccattccata ccctttccgc caaaaatctt tattcccaat cgtaattccc
     9421 agttcagcct gttgattgaa tgcatctatg ttttttaaat caacccagcc tatgtgctta
     9481 ccatttccag tgagaatcgc tttttgttca tacccgtttg atttatccat acatttttga
     9541 atccaatttt tcgtctcctc catagtgaac ggcggatatg tatctggtat atttaaatat
     9601 ttcgttacct ctttatccaa acaccactta taacggtctt ctgcgtcttc cagcttcaac
     9661 tctcttaatg tcacttctgg taatttcatc aagttattct ctccttatta ttttttaaac
     9721 gattgtataa cacggaacct cattgataaa atctgaattt tccttttatt gcagcacttt
     9781 gaataaagaa ggaacagaac atctttcctc gcacctttcg aacgattaac tatgaaacta
     9841 gaattctatt tcttacaatt caagaatgct tctgctacaa tatagctaat tcgattatgg
     9901 aattatattt ccatttgaaa gaatttctga tagtttccat aattacctga tatccacata
     9961 caccgcaggg aaaaataaat agctgaagta aaggaaggaa aaggaatggt acataaacaa
    10021 acgaaacggc ctgtcgtgct tgtcgccctg attctttcta tgtttatggc ggcaatcgaa
    10081 ggaaccattg ttgccactgc aatgcctaat attgtatctg atctgggcgg ttttacatta
    10141 tacagctggg tcttttccag tttcctatta atgcaggcag ttaccacgat ggtatacggc
    10201 aaattagccg acttattcgg ccgcaaaccg atctttgtca tcggtgtcat tatattttta
    10261 attggttcct tattatgcgg attggcagaa agcatgactg ctcttgtcgt gtttcggctt
    10321 atccagggaa ttggagccgg tgctatacat ccgatagtaa ccacgatcgt aggagatatg
    10381 tataatt
//
