LOCUS       NZ_CM000753.1          10267 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  NZ_CM000753.1 Bacillus thuringiensis serovar berliner ATCC 10792
            chromosome, whole genome shotgun sequence.
ACCESSION   NZ_CM000753
VERSION     NZ_CM000753.1
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 6.1.1
            Run date     :: 2024-03-14 14:59:36
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 2402791
            Orig. end    :: 2413058
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..10267
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[2407791:2408058](+)"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193)"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      5001..5267
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193)"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
     cand_cluster    1..10267
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193)"
                     /kind="single"
                     /product="RiPP-like"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..10267
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="RiPP-like"
                     /region_number="7"
                     /rules="(strepbact or Antimicrobial14 or Bacteriocin_IId or
                     BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or
                     Lactococcin or Antimicrobial17 or Lactococcin_972 or
                     Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or
                     TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or
                     TIGR03975 or DUF692 or TIGR01193)"
                     /tool="antismash"
     CDS             978..2339
                     /locus_tag="ctg1_2442"
                     /transl_table=11
                     /translation="MNGKRKIFTCISIVGIGLASFSNSSFAASVTDNSIQNSIPIVNQQ
                     VAAAKEMKPFPQQVNYAGVIKPNHVTQESLNASVRSYYDNWKKKYLKNDLSSLPGGYYV
                     KGEITGDADGFKPLGTSEGQGYGMIITVLMAGYDSNAQKIYDGLFKTARTFKSSQNPNL
                     MGWVVADSKKAQGHFDSATDGDLDIAYSLLLAHKQWGSNGTVNYLKEAQDMITKGIKAS
                     NVTNNNRLNLGDWDSKSSLDTRPSDWMMSHLRAFYEFTGDKTWLTVINNLYDVYTQFSN
                     KYSPNTGLISDFVVKNPPQPAPKDFLDESEYTNAYYYNASRVPLRIVMDYAMYGEKRSK
                     VISDKVSSWIQNKTNGNPSKIVDGYQLNGSNIGSYPTAVFVSPFIAASITSSNNQKWVN
                     SGWDWMKNKRESYFSDSYNLLTMLFITGNWWKPAPDDKKTQNLINDAIYEGYDN"
     PFAM_domain     1221..2249
                     /aSDomain="Glyco_hydro_8"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF01270.19"
                     /description="Glycosyl hydrolases family 8"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_2442_0174"
                     /evalue="3.20E-28"
                     /label="ctg1_2442"
                     /locus_tag="ctg1_2442"
                     /protein_end="424"
                     /protein_start="81"
                     /score="98.6"
                     /tool="antismash"
                     /translation="YYDNWKKKYLKNDLSSLPGGYYVKGEITGDADGFKPLGTSEGQGY
                     GMIITVLMAGYDSNAQKIYDGLFKTARTFKSSQNPNLMGWVVADSKKAQGHFDSATDGD
                     LDIAYSLLLAHKQWGSNGTVNYLKEAQDMITKGIKASNVTNNNRLNLGDWDSKSSLDTR
                     PSDWMMSHLRAFYEFTGDKTWLTVINNLYDVYTQFSNKYSPNTGLISDFVVKNPPQPAP
                     KDFLDESEYTNAYYYNASRVPLRIVMDYAMYGEKRSKVISDKVSSWIQNKTNGNPSKIV
                     DGYQLNGSNIGSYPTAVFVSPFIAASITSSNNQKWVNSGWDWMKNKRESYFSDSYNLLT
                     MLF"
     CDS             2502..3425
                     /locus_tag="ctg1_2443"
                     /transl_table=11
                     /translation="LEKVLFFGDPGIDDSFAIMYGLLHPEIEIVGIVTGYGNVEHIHAA
                     HNAAYILQLANRQDIPVISGATKPLTEEITTYYPEIHGAEGLGPIHVPGNILSIPIYNF
                     GSIAAILIKYGKDLTIVDVGRSTSLAIAFNLWNDLMLNVKGIYFMGGVFLEVGKVTPLA
                     EANVYGDPIASKIVFHQAKNLLIFPLNVTNKAVLTPNVFNYIQANAKNPFHMIMKPMYD
                     YYLSAYQKLNPSMEGPLLHDVVAISGLVNPSFFEFVHRTVNVDTYGDTKGQTFADFRPN
                     SKSEGARIALEIDAEKFIQDFIKIML"
     PFAM_domain     2517..3398
                     /aSDomain="IU_nuc_hydro"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF01156.21"
                     /description="Inosine-uridine preferring nucleoside
                     hydrolase"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_2443_0175"
                     /evalue="1.80E-62"
                     /label="ctg1_2443"
                     /locus_tag="ctg1_2443"
                     /protein_end="299"
                     /protein_start="5"
                     /score="211.8"
                     /tool="antismash"
                     /translation="FFGDPGIDDSFAIMYGLLHPEIEIVGIVTGYGNVEHIHAAHNAAY
                     ILQLANRQDIPVISGATKPLTEEITTYYPEIHGAEGLGPIHVPGNILSIPIYNFGSIAA
                     ILIKYGKDLTIVDVGRSTSLAIAFNLWNDLMLNVKGIYFMGGVFLEVGKVTPLAEANVY
                     GDPIASKIVFHQAKNLLIFPLNVTNKAVLTPNVFNYIQANAKNPFHMIMKPMYDYYLSA
                     YQKLNPSMEGPLLHDVVAISGLVNPSFFEFVHRTVNVDTYGDTKGQTFADFRPNSKSEG
                     ARIALEIDAEKFI"
     CDS             3502..3960
                     /locus_tag="ctg1_2444"
                     /transl_table=11
                     /translation="LNVQLKVVTRDNWEDALKLQVKEDQRKFVPAVAVSLAKVYIKPDG
                     DNVEYIPFAIYDGDLMVGFVMHAVVIETSDMYWINGFIIDQSQQGNGYGKAALQESINI
                     IKNTFKACKEIRLTVHKDNISAKKLYERYGFISLGQEYDGEQVYRLFV"
     PFAM_domain     3646..3906
                     /aSDomain="Acetyltransf_1"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00583.27"
                     /description="Acetyltransferase (GNAT) family"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_2444_0176"
                     /evalue="5.60E-12"
                     /label="ctg1_2444"
                     /locus_tag="ctg1_2444"
                     /protein_end="135"
                     /protein_start="48"
                     /score="46.0"
                     /tool="antismash"
                     /translation="EYIPFAIYDGDLMVGFVMHAVVIETSDMYWINGFIIDQSQQGNGY
                     GKAALQESINIIKNTFKACKEIRLTVHKDNISAKKLYERYGF"
     CDS             3991..4338
                     /locus_tag="ctg1_2445"
                     /transl_table=11
                     /translation="MQFTEVKIEVFIPEEYIETLRDELNKIGACKTGEYDHCLSYSSVK
                     GYWRPLEEASPFNGEIGQICEGQECKVEIKCKRELVKDVLEVINDIHPYETPMIYIIPI
                     LNDYFEKLYIK"
     PFAM_domain     4174..4305
                     /aSDomain="CutA1"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF03091.17"
                     /description="CutA1 divalent ion tolerance protein"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_2445_0177"
                     /evalue="7.80E-08"
                     /label="ctg1_2445"
                     /locus_tag="ctg1_2445"
                     /protein_end="105"
                     /protein_start="61"
                     /score="32.2"
                     /tool="antismash"
                     /translation="GQICEGQECKVEIKCKRELVKDVLEVINDIHPYETPMIYIIPIL"
     CDS             4355..4801
                     /locus_tag="ctg1_2446"
                     /transl_table=11
                     /translation="LKSKFHHIVRAVMIKDEKLLVAEYIGHHYFLPGGHVEIGESAENA
                     LKRELREELGVNCSIQQFLGVIENQWQDKEVLHHEINHIFEVESQDLHTDLTPKSSESH
                     LAFHWIAYNKEALNHYEIMPMPLVKELLESKLNDELLNCWISNF"
     PFAM_domain     4373..4699
                     /aSDomain="NUDIX"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00293.30"
                     /description="NUDIX domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_2446_0178"
                     /evalue="1.10E-15"
                     /label="ctg1_2446"
                     /locus_tag="ctg1_2446"
                     /protein_end="115"
                     /protein_start="6"
                     /score="57.9"
                     /tool="antismash"
                     /translation="HIVRAVMIKDEKLLVAEYIGHHYFLPGGHVEIGESAENALKRELR
                     EELGVNCSIQQFLGVIENQWQDKEVLHHEINHIFEVESQDLHTDLTPKSSESHLAFHWI
                     AYNKE"
     aSDomain        5001..5258
                     /aSDomain="TIGR03601"
                     /aSTool="tigrfam"
                     /description="B_an_ocin: bacteriocin,
                     heterocycloanthracin/sonorensin family"
                     /detection="hmmscan"
                     /domain_id="TIGRFam_ctg1_2447_0038"
                     /evalue="8.30E-36"
                     /identifier="TIGR03601"
                     /label="ctg1_2447"
                     /locus_tag="ctg1_2447"
                     /protein_end="86"
                     /protein_start="0"
                     /score="120.5"
                     /tool="antismash"
                     /translation="MNQFQQELQSLNLNDYQTGNVVYWDQQQSQYPYYYIQDDARRCGG
                     CGGCGGRCGGCGGRCGGCAGRCGGCIGCAGCFSCFNCWNWW"
     CDS             5001..5267
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: TIGR03601"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg1_2447"
                     /sec_met_domain="TIGR03601 (E-value: 1.1e-47, bitscore:
                     158.9, seeds: 6, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNQFQQELQSLNLNDYQTGNVVYWDQQQSQYPYYYIQDDARRCGG
                     CGGCGGRCGGCGGRCGGCAGRCGGCIGCAGCFSCFNCWNWWII"
     CDS             5369..6385
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1053:beta-lactamase (Score: 73.3; E-value: 3.3e-22)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg1_2448"
                     /transl_table=11
                     /translation="LYTYDKLISWVEDIKEKNHSSATALCIIKDNKIVLEHYSGYHSNT
                     STTKRLTASSQFNVASARKSYLGLMIAYALYEGKINSIDDEAIKYFKDFDPALLSKTTI
                     RHLVTHSHGLEETNDRTIFREFAPGQSWAYRDINVRMMTRLIYQLYNKSFPELLKERVF
                     KPANFQETGWRVQRDENLVDVVNNPNEDAISEIGTVDDGTEKNLFVSAREFAQWGNLHL
                     NQGGIDGKQIVPKEVIKIATSLQSPTYINKELPQNGLFWFIQNEPAQLSELGERVPKGS
                     YQILGITGPTILVIPEYNVVVAKMYNKRYNYGGDNYLYYLREFSNLVADTFSNGNRA"
     PFAM_domain     5396..6316
                     /aSDomain="Beta-lactamase"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00144.26"
                     /description="Beta-lactamase"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_2448_0179"
                     /evalue="2.60E-35"
                     /label="ctg1_2448"
                     /locus_tag="ctg1_2448"
                     /protein_end="316"
                     /protein_start="9"
                     /score="122.3"
                     /tool="antismash"
                     /translation="WVEDIKEKNHSSATALCIIKDNKIVLEHYSGYHSNTSTTKRLTAS
                     SQFNVASARKSYLGLMIAYALYEGKINSIDDEAIKYFKDFDPALLSKTTIRHLVTHSHG
                     LEETNDRTIFREFAPGQSWAYRDINVRMMTRLIYQLYNKSFPELLKERVFKPANFQETG
                     WRVQRDENLVDVVNNPNEDAISEIGTVDDGTEKNLFVSAREFAQWGNLHLNQGGIDGKQ
                     IVPKEVIKIATSLQSPTYINKELPQNGLFWFIQNEPAQLSELGERVPKGSYQILGITGP
                     TILVIPEYNVVVAKMYNKRYNYGGDN"
     CDS             6417..6560
                     /locus_tag="ctg1_2449"
                     /transl_table=11
                     /translation="MKDKVNKNKKQNIKDVNTEQNAIYSDPKDAANMQTVPQPKDFDEI
                     EY"
     CDS             6840..8048
                     /gene_functions="transport (smcogs) SMCOG1137:Major
                     facilitator superfamily MFS 1 (Score: 417.1; E-value:
                     1e-126)"
                     /gene_kind="transport"
                     /locus_tag="ctg1_2450"
                     /transl_table=11
                     /translation="MKQTSINPLLIVLGTIIVQIGLGTIYTWSLFNQPLVSKFGWNLNS
                     VAITFSITSFSLSFSTLFAAKLQKKLGLRKLIATAGIVLGLGLILSSQVSSLPLLYLLA
                     GVVVGYADGTAYITSLSNLIKWFPNRKGLISGISVSAYGMGSLIFRYINGNLIDNLGVS
                     QAFLYWGIIVLLLVLIGSFFLREAIVSNAVTETLHNDYTPREMMRTKQVYLLFFMLFTS
                     CMGGLYLISMVKDIGVQLVGLSAASAANAVAMIAIFNTVGRIILGTLSDKIGRMKIVSA
                     TFIIIGLSVFTLSFIPLNYGIYFACVASVAFCFGGNITIFPAIVGDFFGLKNHSTNYGI
                     VYQGFGFGALAGSFIGAILGGFQPTFIIIGVLSVISFIISILIRPPNVEKKKELKHLHR
                     KVA"
     PFAM_domain     6897..7823
                     /aSDomain="MFS_1"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF07690.18"
                     /description="Major Facilitator Superfamily"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_2450_0180"
                     /evalue="7.80E-25"
                     /label="ctg1_2450"
                     /locus_tag="ctg1_2450"
                     /protein_end="328"
                     /protein_start="19"
                     /score="87.6"
                     /tool="antismash"
                     /translation="IGLGTIYTWSLFNQPLVSKFGWNLNSVAITFSITSFSLSFSTLFA
                     AKLQKKLGLRKLIATAGIVLGLGLILSSQVSSLPLLYLLAGVVVGYADGTAYITSLSNL
                     IKWFPNRKGLISGISVSAYGMGSLIFRYINGNLIDNLGVSQAFLYWGIIVLLLVLIGSF
                     FLREAIVSNAVTETLHNDYTPREMMRTKQVYLLFFMLFTSCMGGLYLISMVKDIGVQLV
                     GLSAASAANAVAMIAIFNTVGRIILGTLSDKIGRMKIVSATFIIIGLSVFTLSFIPLNY
                     GIYFACVASVAFCFGGNITIFPAIVGDF"
     CDS             8179..8604
                     /locus_tag="ctg1_2451"
                     /transl_table=11
                     /translation="MKIVQQWVQEDSDYIREKVIEYNQKYLAGEEKTPSEKVSFIVRNE
                     KEEIVGGVTAITFWHHIHVDFLWVSEEYRHEGYGSKLIKLIEEFAIEKECRLINLDTFS
                     FQAPDFYKKHGYKVIGVSEDHPKGHNHYYLEKRLKSI"
     PFAM_domain     8278..8526
                     /aSDomain="Acetyltransf_1"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00583.27"
                     /description="Acetyltransferase (GNAT) family"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_2451_0181"
                     /evalue="2.00E-14"
                     /label="ctg1_2451"
                     /locus_tag="ctg1_2451"
                     /protein_end="116"
                     /protein_start="33"
                     /score="53.9"
                     /tool="antismash"
                     /translation="PSEKVSFIVRNEKEEIVGGVTAITFWHHIHVDFLWVSEEYRHEGY
                     GSKLIKLIEEFAIEKECRLINLDTFSFQAPDFYKKHGY"
     CDS             8884..9327
                     /locus_tag="ctg1_2452"
                     /transl_table=11
                     /translation="MKKVNVTYALLYDKTNEKILMVKNKGENGSYYTLPGGAVKLGETL
                     EEAVIREVKEETGLHINVNGICSISEAFFEERDHHAIFFNFLGEIIGGETYISRPKEIE
                     EITWMELHIAAPYLRIPEHLLDLLQKKETVPYFFNGTIVHQSS"
     PFAM_domain     8902..9225
                     /aSDomain="NUDIX"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00293.30"
                     /description="NUDIX domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_2452_0182"
                     /evalue="5.40E-15"
                     /label="ctg1_2452"
                     /locus_tag="ctg1_2452"
                     /protein_end="114"
                     /protein_start="6"
                     /score="55.7"
                     /tool="antismash"
                     /translation="TYALLYDKTNEKILMVKNKGENGSYYTLPGGAVKLGETLEEAVIR
                     EVKEETGLHINVNGICSISEAFFEERDHHAIFFNFLGEIIGGETYISRPKEIEEITWME
                     LHIA"
ORIGIN
        1 cagcaattcg tctggggctt gaatcttata cgcctgaaca ccttacttta ctacgcttat
       61 taatcgcctc atttatactt ttgttatttt catttatata caaactacga ctaccggatt
      121 taaaggatat cccagcaatt tttatatttg gtgctttagg gtttactatt tatcacatcg
      181 cattaaatta cggcgaaaaa acagtaaatg ctggatctgc aagtttaatt atttcagtca
      241 ccccaatagt gacggcaatt cttgcttctg tttttttgaa tgacaaaatg aaattaaatg
      301 gttggcttgg tggtgtaatt agttttgcag gaattgcctt aatttcattt agccagggcg
      361 atgctattca attgaatagc gggggattat ttatattatt agcggcgatt tcagaaagtc
      421 tatttttcgt tttccaaaca tcttacttaa aaaaatacgg cttcttacca tttaccatat
      481 atacaatttt gtctagtact gtatgtatgc ttattttctt acccggagtt tatcaagaaa
      541 tactaacagc tcctcttgaa gttaacttga gcgttatata tttaggtgtc tttccaacag
      601 tactcccgta tattgcattg gcctatatta tatctcgtgc tggtgcttct gaagcaacaa
      661 gttctctata tttaacgcca ataactgcgt gtttcattgc ttggatatgg ttaggagaag
      721 tcccaacttt agtttcgata attggcggag gaattactat acttggaatt gtgattgctc
      781 atataccagt attaagaaaa gaaaaacata ggaatttagc aaataatcaa tccgtataat
      841 gtaattcaat aatgatttta tgatactttt ttatatagtt tctttcttat gttgataaat
      901 ataatatttt gtatttcagt taaatattgt atgttacatt ttatgtagta agcattttaa
      961 aaggagctga caacataatg aatggaaaaa gaaaaatttt cacatgtatt tctattgtag
     1021 gaatcggact agctagtttt tctaattcta gtttcgcagc aagtgtaacg gacaattcaa
     1081 tacaaaattc tattcccata gttaatcaac aagtagctgc tgcaaaggaa atgaaaccat
     1141 ttccccagca agttaattat gcaggtgtta taaaaccgaa tcatgttaca caggaaagtt
     1201 taaatgcttc tgtaagaagt tactacgata attggaaaaa gaaatatttg aaaaatgatt
     1261 tatcttcttt acctggtggt tattacgtaa aaggagagat tacaggtgat gcggatgggt
     1321 ttaagccact tggaacttca gaaggtcaag gatatgggat gataattaca gtattaatgg
     1381 ctggttatga ttcgaatgct caaaaaatct atgacggttt atttaaaaca gcaagaactt
     1441 ttaaaagctc tcaaaatcct aatttaatgg gatgggttgt cgcagatagt aaaaaagcac
     1501 aaggtcattt tgattctgct actgatgggg atttagatat tgcgtattct cttcttcttg
     1561 ctcataagca gtggggatct aatggaacag ttaattattt gaaagaagca caagacatga
     1621 ttacaaaagg tattaaagct agtaatgtta caaataataa ccgactaaat ttaggagatt
     1681 gggattctaa aagttcactt gatacgagac catctgattg gatgatgtca caccttagag
     1741 cattttatga atttacaggt gataaaactt ggcttactgt tattaataat ttgtacgatg
     1801 tttatacgca atttagtaat aagtactctc caaatacagg acttatttca gatttcgttg
     1861 taaaaaaccc accacaaccc gcacctaaag acttcttaga tgagtcagaa tatacaaatg
     1921 catattatta taatgctagt cgagtacctt taagaattgt aatggactat gcgatgtacg
     1981 gcgagaagcg aagtaaagtc atttctgata aagtctcttc atggattcaa aataaaacga
     2041 atggaaatcc ttctaaaatt gtggatggtt atcaattaaa tggatccaat attggtagtt
     2101 atccaactgc tgtatttgtt tcaccgttta ttgctgcaag tataacgagt agcaataatc
     2161 aaaagtgggt aaatagtggt tgggattgga tgaagaataa gagagaaagt tattttagtg
     2221 atagttataa tttattaact atgttattta ttacaggaaa ttggtggaag cctgcacctg
     2281 atgataaaaa aacacaaaat ctaataaatg atgcaattta tgaaggatac gataattaat
     2341 taaatttgag aatggttact gaagaaagga attagcattc gctagttcct ttttaatgtt
     2401 ttgtaaaaca ttatccattc taaaattcgc atagatatac ttgctttttt catatacata
     2461 gttattgatg actctatgtt tttatgaagg gagagtattt cttggaaaaa gtattatttt
     2521 tcggagaccc aggtattgat gactcatttg ccattatgta tggtttactg catcccgaaa
     2581 ttgaaattgt cggtattgta accggatacg gaaatgttga gcatatacat gctgcacata
     2641 atgcagcgta tattttacag ttagcaaata gacaagacat tcctgtcatt agtggtgcaa
     2701 caaaaccact gacagaagaa atcactacgt actatcctga aattcacgga gcagaaggat
     2761 tagggcccat ccatgttcca ggaaatatat tatctattcc aatatataat ttcggcagta
     2821 ttgctgcgat tcttataaag tacggaaaag atttaacgat tgttgatgta ggaagatcta
     2881 cctcgttagc aattgctttt aatttatgga atgatttaat gctaaatgta aaaggaatct
     2941 atttcatggg tggtgttttt ttagaagtag gaaaggttac gccattagca gaggcaaacg
     3001 tgtatggaga tccgatagca agtaaaattg ttttccatca agcaaagaat ttattaatat
     3061 tccctttaaa tgtaacaaac aaagctgtgt taacaccaaa tgtatttaac tatattcaag
     3121 ctaatgcaaa gaatccattt catatgataa tgaaaccaat gtatgactac tatctatccg
     3181 cataccaaaa acttaatcca tctatggaag gacctttgct acatgatgtg gttgcaataa
     3241 gtggattagt aaatccaagt ttttttgaat ttgtgcatcg tacagtaaat gtagatacat
     3301 acggagatac gaaaggacaa acatttgctg attttcgccc taactctaaa tctgaaggag
     3361 cccgtatagc tttagaaata gatgcagaaa aattcattca agattttata aaaattatgt
     3421 tataagttgc tgtcgaaaaa gggaattatt tcaatgcgtt gaatataaaa atacatcctc
     3481 tagataaagg agcttacaat attgaatgtc cagttaaagg ttgttacgag agacaattgg
     3541 gaagatgcat taaagttaca agttaaagaa gatcaaagaa aatttgtccc cgctgtagca
     3601 gtttcacttg ctaaagtata cataaaacca gatggtgaca atgtagagta cataccattc
     3661 gctatatacg atggtgacct tatggttggt tttgttatgc atgctgttgt aatagagaca
     3721 tcggatatgt attggattaa cggatttatt attgatcaat cgcaacaagg taatggttat
     3781 ggaaaagcag cattacaaga aagtattaat ataataaaaa atacgtttaa ggcgtgtaaa
     3841 gaaattagat taaccgtaca taaagataat atctctgcaa agaaattata tgaacgatat
     3901 ggtttcatat cattaggaca ggagtatgat ggtgagcaag tatatcgttt atttgtttaa
     3961 ctattaggaa gtaaaggtgt gaaatgaaat atgcaattta ctgaagtgaa aattgaagtg
     4021 ttcattcctg aagaatatat tgaaacatta agggatgaat taaataaaat tggagcatgt
     4081 aaaacgggcg aatatgacca ttgtctttcc tatagttcag tgaaaggata ttggagacct
     4141 ttagaagagg catctccttt taatggagaa attggtcaaa tatgcgaagg acaagaatgt
     4201 aaagttgaaa taaagtgtaa acgagaactt gtaaaagatg ttcttgaagt tattaatgat
     4261 attcatccgt atgaaacacc tatgatttat attataccaa tactaaatga ctattttgag
     4321 aaactataca ttaaataact aggaggaata tcaattgaaa agtaaatttc atcatattgt
     4381 acgagcagtc atgataaaag atgaaaaatt attagttgct gaatatatcg gccatcatta
     4441 ttttttacct ggtggccatg ttgaaattgg agaatcagca gagaatgcat taaaaagaga
     4501 gttaagagaa gaacttggag taaactgtag tatacaacaa tttttaggcg tcatagaaaa
     4561 tcaatggcaa gataaagaag ttcttcatca tgaaattaac cacatttttg aagtagagtc
     4621 acaagattta catacggact taacaccgaa atctagcgag tctcatttag catttcactg
     4681 gatagcttat aataaagaag ccttaaatca ttatgaaatc atgccaatgc ctttagtaaa
     4741 ggaattacta gaaagtaagt taaatgatga actcctaaat tgttggatta gtaattttta
     4801 aatcacttta tttatagtaa atacgtccat cgaatgaata taaagaaaat aggctgaaaa
     4861 acaaggtaca tcacctagtg taagttcata ttttgttgat gtacgcattt agtctatagt
     4921 cttgtttcta ctttgtttaa aagaatttat taactttaat atttggacgg aatttacatt
     4981 tataaatgga gggtttcata atgaatcagt ttcaacaaga actacaatca ttaaacctta
     5041 atgattatca aactggcaat gttgtgtatt gggatcaaca acaaagtcaa tatccatact
     5101 attacattca agacgatgca cgtcgttgcg gcggatgtgg cggttgtggt ggacgttgcg
     5161 gtggatgtgg cggtagatgt ggtggttgtg caggtcgttg cggcggatgt ataggatgcg
     5221 caggatgttt cagttgcttt aattgctgga actggtggat tatttaagta tagaaaatcc
     5281 aagttatttt atatgaaaga aaggtgtaaa aactattttg cacttttctt tcatgctgta
     5341 attttgatgt gtattaaggg ggatttattt gtatacatat gataagttga tttcttgggt
     5401 agaggatata aaagaaaaaa atcatagttc tgctacagca ctttgtatta taaaagataa
     5461 taaaatcgta ctagagcatt atagtggtta tcactcaaat acatctacaa ccaagagatt
     5521 aacagcatct tcacaattta acgttgcttc tgctagaaaa agttatttag gattaatgat
     5581 agcgtatgcg ctttatgagg ggaaaataaa ctctattgat gatgaagcga taaaatattt
     5641 taaagacttt gatcctgcat tgcttagtaa aacgacgata agacatttag taacacattc
     5701 gcacggatta gaagaaacga atgacaggac aatttttcgt gaatttgcac cgggacaatc
     5761 atgggcgtat agagatatta atgtaagaat gatgacacgt cttatttatc agctatataa
     5821 caaaagtttt cctgaattgt taaaggagcg tgtgtttaaa cctgctaatt ttcaagaaac
     5881 aggttggaga gttcagcgag atgaaaattt agttgacgtt gttaataatc caaatgaaga
     5941 cgcaattagt gaaattggta cggtagatga cggtactgaa aaaaatttgt ttgtctcagc
     6001 tagagaattt gcgcagtggg gcaatcttca tttaaatcaa ggtgggatag atggtaaaca
     6061 aattgttcca aaagaagtta taaaaatcgc tacgagtttg cagagtccaa catatataaa
     6121 caaagagcta ccacaaaatg gattgttttg gttcatccaa aatgagcctg cgcaattaag
     6181 cgaacttggt gaacgtgttc caaaagggtc gtatcaaata ttagggatta ctggaccgac
     6241 cattttagta atacctgaat ataatgtagt tgttgcaaaa atgtataata aaagatataa
     6301 ctacggtggt gataattact tatattattt acgtgaattt agtaatttag tcgctgatac
     6361 atttagtaac ggtaataggg cataattact cctataacaa aaaggagtga ttgaaaatga
     6421 aagataaagt gaacaaaaat aaaaagcaaa atataaaaga tgtaaataca gagcaaaatg
     6481 caatttatag cgatcctaaa gatgcagcta atatgcaaac tgtaccgcag ccgaaagatt
     6541 ttgatgaaat cgaatattaa tttttcatcc gactatatga tgaatgaaaa atacgtctta
     6601 agtctcataa catttaagaa attatttgat aacatatata cataagcatt tgaaaatgtc
     6661 ttatcttaac aaagctttct ttagaaatat ctgatataac ctgcaaaagg cacttcttta
     6721 tgaagtgtct ttttgtgtat atgaacttaa ttaccatttt ccgtacagta tcttgcaatt
     6781 tatgatggat atactaactg tgaaaattca tgtcaagata aaagaagggg acagttagta
     6841 tgaaacaaac ttctataaat ccgttactaa ttgttctagg tacaatcatt gttcaaattg
     6901 gccttggaac aatttataca tggagtttat ttaatcaacc ccttgtaagt aagtttggat
     6961 ggaatcttaa ttcagtagcg ataactttct ccataactag tttttcttta tcattctcaa
     7021 ctttatttgc agccaagttg cagaaaaaat taggacttcg aaaacttatt gctactgcag
     7081 gaattgtttt aggactcggc ttaatactta gttcacaagt ttcttcttta ccactattat
     7141 atttattagc tggtgtcgtt gttggttatg cggatggaac agcttatatt acatcactat
     7201 ctaatttaat taaatggttt ccaaatcgga aagggcttat ttcaggtata tctgtatcag
     7261 cgtatggaat gggcagctta atctttagat atataaacgg aaatcttatc gataaccttg
     7321 gtgtatcaca agcattctta tattggggta ttatcgtgtt acttttagtg ttaatcggat
     7381 cgttcttctt acgtgaggca attgtaagta atgctgtaac tgaaacatta cacaatgact
     7441 atactccgcg tgaaatgatg cgaacgaaac aagtatatct gctatttttt atgttattca
     7501 cctcgtgtat gggtggtttg tatttaatca gtatggtaaa agatatcggc gtacaacttg
     7561 ttggacttag cgcagcatcc gctgcaaacg ccgttgctat gattgcaatc tttaatacag
     7621 taggtagaat cattcttggg acgttatcag ataaaatcgg gcgaatgaaa attgtctctg
     7681 caacgtttat tattataggt ttgtcagtct ttactttaag ttttattccg ctaaattacg
     7741 ggatctattt tgcttgtgta gcaagtgtcg ccttttgctt cggcggtaat ataactatat
     7801 tcccagctat tgtcggagat ttctttggat taaaaaacca tagtacaaat tacgggattg
     7861 tctaccaagg tttcggattt ggtgcgcttg caggatcatt tattggagcg atactcgggg
     7921 gatttcaacc aactttcatt ataatcggtg ttttaagtgt tatttccttc attatttcaa
     7981 tattaatccg tccaccaaat gtagaaaaga aaaaggaact aaaacattta catcggaaag
     8041 tagcttaatt ttaaaaagag tcctcatact agggctcttt tttattccat taactttgct
     8101 tctttactaa ctcattaaag acaggacaat atcattttaa aattgaatag ataagtaaaa
     8161 aggagcgtga cacttaaaat gaaaatagta cagcagtggg tacaagaaga tagtgattac
     8221 ataagagaga aagtaattga atacaatcaa aaatatcttg caggtgaaga aaaaacacct
     8281 tcagaaaagg ttagtttcat agtaagaaat gaaaaagaag aaatagtagg tggggtaaca
     8341 gcaataactt tttggcacca tatacacgtt gactttctat gggtttctga agaatatagg
     8401 catgaaggtt acggaagcaa gttaataaag cttattgaag agtttgcaat tgaaaaagag
     8461 tgcaggttaa tcaacttaga tacttttagt tttcaggcac ctgattttta taagaagcat
     8521 ggatataaag taatcggagt aagtgaagat catccgaaag gacataatca ttattattta
     8581 gaaaaacggc taaaaagtat atagaatttg ttaacattag tatttggaat aaacatgcaa
     8641 taagggcgag gttattatta atttcagtat taattgaatc aatttttatt ctaaaactgc
     8701 aagaacgtac tttggataat cttcctaagg tacgttcttt ttttatatca gtagcctatt
     8761 cttattaatt ccaccaatac tggtaaaggc aagacttaac taacttatat atattaaaag
     8821 gagttaatgg taaaatgaat agaagacaga aaattccttt tattaaaaat agaggaggta
     8881 catatgaaaa aagtaaatgt tacatatgca cttttatacg ataaaacaaa cgaaaagatc
     8941 ttaatggtaa aaaacaaagg ggaaaatggt tcttattata cattaccagg tggcgcagtt
     9001 aaattaggag aaacgttaga agaagcagta attcgagaag taaaagaaga aacagggtta
     9061 catataaatg taaacgggat ttgttctatc agcgaagcct tttttgagga aagagatcat
     9121 catgcaattt tctttaattt tctaggtgaa ataattggcg gagagacata tatatcaagg
     9181 ccaaaagaaa ttgaagagat tacttggatg gaattacata tagcagcacc gtatttacgc
     9241 ataccagaac atttactaga tttattacaa aagaaagaaa cagtacctta tttttttaac
     9301 ggaacaatcg ttcatcaatc ttcataaaaa tattatctca tgtaaggcgg ggaaaacatg
     9361 gagtttatcg ttaatcacaa acaattcact caagcacttt cagaagtaag taaagcaata
     9421 tcaacaaaat ctttaattcc tatattatct ggtataaaaa taactgcaga tcaatctgga
     9481 attactttaa tcgcaagtaa ctcgaatatt tttatcgaaa aattcattcc tgtttcaatt
     9541 gaagacgaaa agattgcaac tattttaaag gcaggaacta ttgttgtacc tgcaaagtat
     9601 ttcattgaaa taataaagaa aatgccaagt gatatagcaa taaaaagtaa gaatgagcaa
     9661 ttaattacga tacaatcaga agaaatcaca ttaagtttaa atggatttcc tgcagatgag
     9721 tttccgaatg taccgcttat agacaatcat gcagaaatca aagtagagac agagcaattg
     9781 attgaagtat ttaaacaaac agtctttgcg gtagcgaaaa atgaatctag acctgttctt
     9841 actggggtgc atatagagtt atctaataat aagttaattt gtgctgcaac tgactcacat
     9901 agactagcga tacgtgaaac attgctttcc tcagatgtaa aagcaaattg tattgtacca
     9961 agcgcaacca ttagtgaact tctaaaatta atgaacagca attcagaatt cgtatatatc
    10021 tatctttcag agagtcatat tatatttacg ctcggaacaa ctacattata ttcaagacta
    10081 atcgaaggta aatatcctaa tatttctaat cttattccga acgactttaa aacgattatt
    10141 aacatagata gaaaaaagat attacaaggt gtagaccgat caagtttatt agcaagtgaa
    10201 tgggccaata acaatgttaa cttagaaatc ataaacgaat ctacaattaa aatttcttca
    10261 aacgctt
//
