Select genomic region:
Overview
1.1
1.2
1.3
1.4
1.5
1.6
1.7
1.8
1.9
1.10
1.11
1.12
1.13
1.14

### Identified secondary metabolite regions using strictness 'relaxed'

NC_000964.3

Region | Type | From | To | Most similar known cluster | Similarity
--- | --- | --- | --- | --- | ---
Region 1 | ranthipeptide,sactipeptide | 204,175 | 226,248 | sporulation killing factor | RiPP:Head-to-tailcyclized peptide | 100%
Region 2 | NRPS | 358,303 | 421,744 | surfactin | NRP:Lipopeptide | 82%
Region 3 | terpene | 1,149,958 | 1,170,476 |
Region 4 | transAT-PKS,PKS-like,T3PKS,NRPS | 1,763,763 | 1,869,009 | bacillaene | Polyketide + NRP | 100%
Region 5 | NRPS,betalactone | 1,940,625 | 2,017,660 | fengycin | NRP | 100%
Region 6 | terpene | 2,092,168 | 2,114,066 |
Region 7 | glycocin | 2,259,521 | 2,279,691 | sublancin 168 | RiPP:Lanthipeptide | 100%
Region 8 | T3PKS | 2,296,956 | 2,338,053 |
Region 9 | NRPS | 3,260,519 | 3,307,655 | bacillibactin | NRP | 100%
Region 10 | CDPS | 3,593,821 | 3,614,567 |
Region 11 | sactipeptide | 3,826,058 | 3,847,669 | subtilosin A | RiPP:Thiopeptide | 100%
Region 12 | other | 3,850,668 | 3,892,086 | bacilysin | Other | 100%
Region 13 | RRE-containing | 4,088,150 | 4,108,419 |
Region 14 | epipeptide | 4,115,742 | 4,137,440 | thailanstatin A | NRP + Polyketide | 10%

NC_000964.3 - Region 1 - ranthipeptide,sactipeptide
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 204,175 - 226,248 nt. (total: 22,074 nt) Show pHMM detection rules used
ranthipeptide: (TIGR03973 or SCIFF or (cds(PF04055 and (TIGR04085 or SPASM)) and minimum(1, [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE, Cytolysin_C_RRE, Goadsporin_CD_RRE, Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE, Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE, Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE, Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE, Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE, Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE, Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE, Thiaglutamate_B_RRE, Thiaglutamate_G_RRE, Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE, Thurincin_rSAM_RRE, Trifolitoxin_RRE]) and not (TIGR01716 or subtilosin or TIGR02111 or TIGR03966 or TIGR04103 or YcaO or TIGR03882)))
sactipeptide: (subtilosin or thuricin or TIGR04404 or Subtilosin_A or skfc)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
MIBiG comparison
KnownClusterBlast
Sactipeptides
Pfam domains
TIGRFAM domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | ranthipeptide | sactipeptide | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | --- | ---
BGC0000601.1 |  |  | 2.00 | RiPP | sporulation killing factor | Bacillus subtilis subsp. subtilis str. 168
BGC0000563.1 |  |  | 0.47 | RiPP | venezuelin | Streptomyces venezuelae ATCC 10712
BGC0001733.1 |  |  | 0.46 | RiPP | PcpA | Pleurocapsa sp. PCC 7327
BGC0000513.1 |  |  | 0.40 | RiPP | Ery-9, Ery-6, Ery-8, Ery-7, Ery-5, Ery-4, Ery-3 | Saccharopolyspora erythraea NRRL 2338
BGC0001171.1 |  |  | 0.37 | RiPP | listeriolysin S | Listeria monocytogenes serotype 4b str. F2365
BGC0000922.1 |  |  | 0.37 | Other | pseudomonas quinolone signal (PQS) | Pseudomonas aeruginosa PAO1
BGC0000539.1 |  |  | 0.33 | RiPP | nukacin ISK-1 | Staphylococcus warneri
BGC0001210.1 |  |  | 0.33 | RiPP | pseudomycoicidin | Bacillus pseudomycoides DSM 12442
BGC0000626.1 |  |  | 0.32 | RiPP | thuricin | Bacillus thuringiensis
BGC0000515.1 |  |  | 0.32 | RiPP | geobacillin I | Geobacillus thermodenitrificans NG80-2

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000601.1 |  | 1.00 | RiPP | sporulation killing factor | Bacillus subtilis subsp. subtilis str. 168
BGC0000563.1 |  | 0.57 | RiPP | venezuelin | Streptomyces venezuelae ATCC 10712
BGC0001733.1 |  | 0.56 | RiPP | PcpA | Pleurocapsa sp. PCC 7327
BGC0000513.1 |  | 0.52 | RiPP | Ery-9, Ery-6, Ery-8, Ery-7, Ery-5, Ery-4, Ery-3 | Saccharopolyspora erythraea NRRL 2338
BGC0001171.1 |  | 0.50 | RiPP | listeriolysin S | Listeria monocytogenes serotype 4b str. F2365
BGC0000922.1 |  | 0.50 | Other | pseudomonas quinolone signal (PQS) | Pseudomonas aeruginosa PAO1
BGC0000539.1 |  | 0.48 | RiPP | nukacin ISK-1 | Staphylococcus warneri
BGC0001210.1 |  | 0.47 | RiPP | pseudomycoicidin | Bacillus pseudomycoides DSM 12442
BGC0000626.1 |  | 0.47 | RiPP | thuricin | Bacillus thuringiensis
BGC0000515.1 |  | 0.47 | RiPP | geobacillin I | Geobacillus thermodenitrificans NG80-2

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.
Sactipeptide predictions
Lists the possible core peptides for each biosynthetic enzyme, including the predicted class. Each core peptide shows the leader and core peptide sequences, separated by a dash.
Sactipeptides - No core peptides found.
Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
Sactipeptides
Core peptide predictions
Lists the possible core peptides in the region. Each core peptide lists its RODEO score and predicted core sequence.
No core peptides found.
NC_000964.3 - Region 2 - NRPS
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 358,303 - 421,744 nt. (total: 63,442 nt) Show pHMM detection rules used
NRPS: cds(Condensation and (AMP-binding or A-OX))

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
NRPS/PKS domains
MIBiG comparison
KnownClusterBlast
NRPS/PKS modules
Pfam domains
TIGRFAM domains
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
A glossary is available here.
Selected features only
Show module domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | NRPS | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000433.1 |  | 0.43 | NRP | surfactin | Bacillus velezensis FZB42
BGC0000389.1 |  | 0.42 | NRP | massetolide A | Pseudomonas fluorescens SS101
BGC0001050.1 |  | 0.37 | NRP, Polyketide | thalassospiramide A | Tistrella bauzanensis
BGC0000438.1 |  | 0.36 | NRP | syringopeptin 25A | Pseudomonas syringae pv. syringae
BGC0001833.1 |  | 0.33 | NRP | icosalide A, icosalide B | Burkholderia gladioli
BGC0000426.1 |  | 0.33 | NRP | sevadicin | Paenibacillus larvae
BGC0001767.1 |  | 0.33 | NRP | salinichelins | Salinispora pacifica CNY331
BGC0000417.1 |  | 0.32 | NRP | rhodochelin | Rhodococcus jostii RHA1
BGC0001615.1 |  | 0.32 | NRP | hexose-palythine-serine, hexose-shinorine | Heteroscytonema crispum UCFS10
BGC0001890.1 |  | 0.32 | NRP | amphi-enterobactin 1, amphi-enterobactin 2, amphi-enterobactin 3, amphi-enterobactin 4 | Vibrio campbellii ATCC BAA-1116

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000433.1 |  | 0.74 | NRP | surfactin | Bacillus velezensis FZB42
BGC0000389.1 |  | 0.74 | NRP | massetolide A | Pseudomonas fluorescens SS101
BGC0001050.1 |  | 0.70 | NRP, Polyketide | thalassospiramide A | Tistrella bauzanensis
BGC0000438.1 |  | 0.69 | NRP | syringopeptin 25A | Pseudomonas syringae pv. syringae
BGC0001833.1 |  | 0.67 | NRP | icosalide A, icosalide B | Burkholderia gladioli
BGC0000426.1 |  | 0.66 | NRP | sevadicin | Paenibacillus larvae
BGC0001767.1 |  | 0.66 | NRP | salinichelins | Salinispora pacifica CNY331
BGC0000417.1 |  | 0.66 | NRP | rhodochelin | Rhodococcus jostii RHA1
BGC0001615.1 |  | 0.66 | NRP | hexose-palythine-serine, hexose-shinorine | Heteroscytonema crispum UCFS10
BGC0001890.1 |  | 0.65 | NRP | amphi-enterobactin 1, amphi-enterobactin 2, amphi-enterobactin 3, amphi-enterobactin 4 | Vibrio campbellii ATCC BAA-1116

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.
Module view
Shows module structures for each candidate in NRPS- and PKS regions. Genes are shown in predicted order, and are only present when containing at least one complete module. A domain glossary is available here.
Legend
Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
NRPS/PKS products
NRPS/PKS monomers
Predicted core structure(s)
Shows estimated product structure and polymer for each candidate cluster in the region. To show the product, click on the expander or the candidate cluster feature drawn in the overview.
For candidate cluster 2, location 358302 - 421744:
Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:
  (glu - leu - D-leu) + (val - asp - D-leu) + (leu)

Direct lookup in NORINE database: strict or relaxed
Link to NORINE database query form
NRPS/PKS monomer predictions
Shows the predicted monomers for each adynelation domain and acyltransferase within genes. Each gene prediction can be expanded to view detailed predictions of each domain. Each prediction can be expanded to view the predictions by tool (and, for some tools, further expanded for extra details).

ctg1_354: glu - leu - leu
  Search NORINE for peptide: strict or relaxed
  AMP-binding (466..867): glu
  NRPSPredictor2: glu
  SVM prediction details:
    Predicted physicochemical class:
      hydrophilic
    Large clusters prediction:
      asp, asn, glu, gln, aad
    Small clusters prediction:
      glu, gln
    Single AA prediction:
      N/A
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DAKDLGVVDK
    Nearest Stachelhaus code:
      glu
    Stachelhaus code match:
      100% (strong)
  AMP-binding (1510..1908): leu
  NRPSPredictor2: leu
  SVM prediction details:
    Predicted physicochemical class:
      hydrophobic-aliphatic
    Large clusters prediction:
      gly, ala, val, leu, ile, abu, iva
    Small clusters prediction:
      val, leu, ile, abu, iva
    Single AA prediction:
      leu
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DAFMMGMVFK
    Nearest Stachelhaus code:
      leu
    Stachelhaus code match:
      100% (strong)
  AMP-binding (2550..2938): leu
  NRPSPredictor2: leu
  SVM prediction details:
    Predicted physicochemical class:
      hydrophobic-aliphatic
    Large clusters prediction:
      gly, ala, val, leu, ile, abu, iva
    Small clusters prediction:
      val, leu, ile, abu, iva
    Single AA prediction:
      leu
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DAWFLGNVVK
    Nearest Stachelhaus code:
      leu
    Stachelhaus code match:
      100% (strong)
ctg1_355: val - asp - leu
  Search NORINE for peptide: strict or relaxed
  AMP-binding (470..864): val
  NRPSPredictor2: val
  SVM prediction details:
    Predicted physicochemical class:
      hydrophobic-aliphatic
    Large clusters prediction:
      gly, ala, val, leu, ile, abu, iva
    Small clusters prediction:
      val, leu, ile, abu, iva
    Single AA prediction:
      val
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DAFWIGGTFK
    Nearest Stachelhaus code:
      val
    Stachelhaus code match:
      100% (strong)
  AMP-binding (1501..1904): asp
  NRPSPredictor2: asp
  SVM prediction details:
    Predicted physicochemical class:
      hydrophilic
    Large clusters prediction:
      asp, asn, glu, gln, aad
    Small clusters prediction:
      asp, asn
    Single AA prediction:
      asp
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DLTKVGHIGK
    Nearest Stachelhaus code:
      asp
    Stachelhaus code match:
      100% (strong)
  AMP-binding (2546..2934): leu
  NRPSPredictor2: leu
  SVM prediction details:
    Predicted physicochemical class:
      hydrophobic-aliphatic
    Large clusters prediction:
      gly, ala, val, leu, ile, abu, iva
    Small clusters prediction:
      val, leu, ile, abu, iva
    Single AA prediction:
      leu
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DAWFLGNVVK
    Nearest Stachelhaus code:
      leu
    Stachelhaus code match:
      100% (strong)
ctg1_356: leu
  Search NORINE for peptide: strict or relaxed
  AMP-binding (469..867): leu
  NRPSPredictor2: leu
  SVM prediction details:
    Predicted physicochemical class:
      hydrophobic-aliphatic
    Large clusters prediction:
      gly, ala, val, leu, ile, abu, iva
    Small clusters prediction:
      val, leu, ile, abu, iva
    Single AA prediction:
      leu
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DAFFLGCVFK
    Nearest Stachelhaus code:
      leu
    Stachelhaus code match:
      100% (strong)

NC_000964.3 - Region 3 - terpene
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 1,149,958 - 1,170,476 nt. (total: 20,519 nt) Show pHMM detection rules used
terpene: (Terpene_synth or Terpene_synth_C or phytoene_synt or Lycopene_cycl or terpene_cyclase or NapT7 or fung_ggpps or fung_ggpps2 or trichodiene_synth or TRI5)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
MIBiG comparison
KnownClusterBlast
Pfam domains
TIGRFAM domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | terpene | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000885.1 |  | 0.29 | Other | 4-hydroxy-3-nitrosobenzamide | Streptomyces murayamaensis
BGC0000846.1 |  | 0.27 | Other | tabtoxin | Pseudomonas syringae
BGC0001735.1 |  | 0.26 | Other | pentostatine, vidarabine | Streptomyces antibioticus
BGC0000937.1 |  | 0.23 | Other | fosfazinomycin A | Streptomyces sp. WM6372
BGC0001739.1 |  | 0.20 | Other | phosphonoacetic Acid | Streptomyces sp. NRRL F-525
BGC0000928.1 |  | 0.19 | Other | T3 toxin | Cylindrospermopsis raciborskii T3
BGC0000188.1 |  | 0.19 | Alkaloid | saxitoxin, neosaxitoxin, decarbamoylsaxitoxin, gonyautoxin 3, gonyautoxin 2 | Cylindrospermopsis raciborskii T3
BGC0000887.1 |  | 0.17 | Alkaloid | saxitoxin, gonyautoxin 2, gonyautoxin 3, toxin C2, toxin C3, gonyautoxin 5, decarbamoylsaxitoxin, decarbamoylgonyautoxin 2, decarbamoylgonyautoxin 3 | Dolichospermum circinale AWQC131C
BGC0001374.1 |  | 0.17 | Other | thienodolin | Streptomyces albogriseolus
BGC0000502.1 |  | 0.16 | RiPP | cerecidin, cerecidin A1, cerecidin A2, cerecidin A3, cerecidin A4, cerecidin A5, cerecidin A6, cerecidin A7 | Bacillus cereus

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000885.1 |  | 0.63 | Other | 4-hydroxy-3-nitrosobenzamide | Streptomyces murayamaensis
BGC0000846.1 |  | 0.61 | Other | tabtoxin | Pseudomonas syringae
BGC0001735.1 |  | 0.60 | Other | pentostatine, vidarabine | Streptomyces antibioticus
BGC0000937.1 |  | 0.56 | Other | fosfazinomycin A | Streptomyces sp. WM6372
BGC0001739.1 |  | 0.53 | Other | phosphonoacetic Acid | Streptomyces sp. NRRL F-525
BGC0000928.1 |  | 0.51 | Other | T3 toxin | Cylindrospermopsis raciborskii T3
BGC0000188.1 |  | 0.51 | Alkaloid | saxitoxin, neosaxitoxin, decarbamoylsaxitoxin, gonyautoxin 3, gonyautoxin 2 | Cylindrospermopsis raciborskii T3
BGC0000887.1 |  | 0.49 | Alkaloid | saxitoxin, gonyautoxin 2, gonyautoxin 3, toxin C2, toxin C3, gonyautoxin 5, decarbamoylsaxitoxin, decarbamoylgonyautoxin 2, decarbamoylgonyautoxin 3 | Dolichospermum circinale AWQC131C
BGC0001374.1 |  | 0.48 | Other | thienodolin | Streptomyces albogriseolus
BGC0000502.1 |  | 0.47 | RiPP | cerecidin, cerecidin A1, cerecidin A2, cerecidin A3, cerecidin A4, cerecidin A5, cerecidin A6, cerecidin A7 | Bacillus cereus

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.

No matches found.

Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
NC_000964.3 - Region 4 - NRPS,PKS-like,T3PKS,transAT-PKS
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 1,763,763 - 1,869,009 nt. (total: 105,247 nt) Show pHMM detection rules used
transAT-PKS: (cds(PKS_AT and not (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS)) and (cds(ATd and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS)) or cds(tra_KS and PP-binding)))
PKS-like: (t2pks2 or ksIII)
T3PKS: (Chal_sti_synt_C or Chal_sti_synt_N)
NRPS: cds(Condensation and (AMP-binding or A-OX))

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
NRPS/PKS domains
MIBiG comparison
KnownClusterBlast
NRPS/PKS modules
Pfam domains
TIGRFAM domains
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
A glossary is available here.
Selected features only
Show module domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | transAT-PKS | PKS-like | T3PKS | NRPS | NRPS | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | --- | --- | --- | --- | ---
BGC0000205.1 |  |  |  |  |  | 1.26 | Polyketide | bryostatin | Candidatus Endobugula sertula
BGC0001089.1 |  |  |  |  |  | 1.14 | Polyketide, NRP | bacillaene | Bacillus velezensis FZB42
BGC0001050.1 |  |  |  |  |  | 1.01 | NRP, Polyketide | thalassospiramide A | Tistrella bauzanensis
BGC0000353.1 |  |  |  |  |  | 0.96 | NRP | tacrolimus | Streptomyces sp. MA6548
BGC0000836.1 |  |  |  |  |  | 0.95 | Other | APE Ec | Escherichia coli CFT073
BGC0001909.1 |  |  |  |  |  | 0.93 | Polyketide | strobilurin | Strobilurus tenacellus
BGC0001132.1 |  |  |  |  |  | 0.92 | NRP | xenotetrapeptide | Xenorhabdus nematophila ATCC 19061
BGC0001235.1 |  |  |  |  |  | 0.92 | NRP, Polyketide | antalid | Polyangium spumosum
BGC0001833.1 |  |  |  |  |  | 0.91 | NRP | icosalide A, icosalide B | Burkholderia gladioli
BGC0002008.1 |  |  |  |  |  | 0.91 | Other | aryl polyenes | Xenorhabdus doucetiae

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001089.1 |  | 0.77 | Polyketide, NRP | bacillaene | Bacillus velezensis FZB42
BGC0000174.1 |  | 0.68 | Polyketide | bryostatin | Candidatus Endobugula sertula
BGC0000205.1 |  | 0.65 | Polyketide | bryostatin | Candidatus Endobugula sertula
BGC0001310.1 |  | 0.61 | Terpene | naringenin | Streptomyces clavuligerus ATCC 27064
BGC0000220.1 |  | 0.60 | Polyketide | enterocin | Streptomyces maritimus
BGC0000835.1 |  | 0.59 | Polyketide | simocyclinone | Streptomyces antibioticus
BGC0001075.1 |  | 0.59 | Terpene, Polyketide | aurachin RE | Rhodococcus erythropolis
BGC0000836.1 |  | 0.58 | Other | APE Ec | Escherichia coli CFT073
BGC0001485.1 |  | 0.58 | Other | 3-demethylchuangxinmycin | Actinoplanes tsinanensis
BGC0001546.1 |  | 0.58 | Alkaloid | chuangxinmycin | Actinoplanes tsinanensis

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.
Module view
Shows module structures for each candidate in NRPS- and PKS regions. Genes are shown in predicted order, and are only present when containing at least one complete module. A domain glossary is available here.
Legend
Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
NRPS/PKS products
NRPS/PKS monomers
Predicted core structure(s)
Shows estimated product structure and polymer for each candidate cluster in the region. To show the product, click on the expander or the candidate cluster feature drawn in the overview.
For candidate cluster 4, location 1763762 - 1869009:
Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:
  (gly - ccmal - ohmal - mal) + (ccmal - mal - ohmal - mal) + (Me-ccmal - ohmal - mal) + (X - ccmal - ccmal - Me-ccmal) + (mal - mal)

Direct lookup in NORINE database: strict or relaxed

For candidate cluster 5, location 1763762 - 1854341:
Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:
  (gly - ccmal - ohmal - mal) + (ccmal - mal - ohmal - mal) + (Me-ccmal - ohmal - mal) + (X - ccmal - ccmal - Me-ccmal) + (mal - mal)

Direct lookup in NORINE database: strict or relaxed
Link to NORINE database query form
NRPS/PKS monomer predictions
Shows the predicted monomers for each adynelation domain and acyltransferase within genes. Each gene prediction can be expanded to view detailed predictions of each domain. Each prediction can be expanded to view the predictions by tool (and, for some tools, further expanded for extra details).

ctg1_1760: mal
  PKS_AT (4..284): mal
  ATSignature: Malonyl-CoA
  Top 3 matches:
    Malonyl-CoA: 87.5%
    inactive: 62.5%
  minowa: Malonyl-CoA
  Prediction, score:
    Malonyl-CoA: 99.9
    Methoxymalonyl-CoA: 55.7
    Methylmalonyl-CoA: 38.0
    inactive: 36.3
    Propionyl-CoA: 24.0
    2-Methylbutyryl-CoA: 13.4
    Isobutyryl-CoA: 13.2
    Ethylmalonyl-CoA: 12.1
    CHC-CoA: 10.6
    trans-1,2-CPDA: 0.0
    fatty_acid: 0.0
    Benzoyl-CoA: 0.0
    Acetyl-CoA: 0.0
    3-Methylbutyryl-CoA: 0.0
ctg1_1762: pk
  PKS_AT (7..293): pk
  ATSignature: (unknown)
  No matches above 50%
  minowa: inactive
  Prediction, score:
    inactive: 30.1
    Malonyl-CoA: 24.5
    Benzoyl-CoA: 8.7
    Isobutyryl-CoA: 8.6
    trans-1,2-CPDA: 0.0
    fatty_acid: 0.0
    Propionyl-CoA: 0.0
    Methylmalonyl-CoA: 0.0
    Methoxymalonyl-CoA: 0.0
    Ethylmalonyl-CoA: 0.0
    CHC-CoA: 0.0
    Acetyl-CoA: 0.0
    3-Methylbutyryl-CoA: 0.0
    2-Methylbutyryl-CoA: 0.0
ctg1_1763: mal
  PKS_AT (4..288): mal
  ATSignature: Malonyl-CoA
  Top 3 matches:
    Malonyl-CoA: 87.5%
    inactive: 66.7%
  minowa: Malonyl-CoA
  Prediction, score:
    Malonyl-CoA: 96.2
    inactive: 40.7
    Methoxymalonyl-CoA: 29.2
    Methylmalonyl-CoA: 22.2
    Propionyl-CoA: 16.2
    trans-1,2-CPDA: 0.0
    fatty_acid: 0.0
    Isobutyryl-CoA: 0.0
    Ethylmalonyl-CoA: 0.0
    CHC-CoA: 0.0
    Benzoyl-CoA: 0.0
    Acetyl-CoA: 0.0
    3-Methylbutyryl-CoA: 0.0
    2-Methylbutyryl-CoA: 0.0
ctg1_1769: pk - gly
  Search NORINE for peptide: strict or relaxed
  CAL_domain (60..476): pk
  minowa: fatty_acid
  Prediction, score:
    fatty_acid: 16.2
    NH2: 10.3
    shikimic_acid: 0.0
    Acetyl-CoA: 0.0
    AHBA: 0.0
  AMP-binding (1159..1554): gly
  NRPSPredictor2: gly
  SVM prediction details:
    Predicted physicochemical class:
      hydrophobic-aliphatic
    Large clusters prediction:
      gly, ala, val, leu, ile, abu, iva
    Small clusters prediction:
      gly, ala
    Single AA prediction:
      gly
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DILQLGMIWK
    Nearest Stachelhaus code:
      gly
    Stachelhaus code match:
      100% (strong)
ctg1_1772: X
  Search NORINE for peptide: strict or relaxed
  AMP-binding (497..905): X
  NRPSPredictor2: hydrophobic-aliphatic
  SVM prediction details:
    Predicted physicochemical class:
      hydrophobic-aliphatic
    Large clusters prediction:
      N/A
    Small clusters prediction:
      N/A
    Single AA prediction:
      N/A
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DVsnmAiIYK
    Nearest Stachelhaus code:
      ala
    Stachelhaus code match:
      60% (weak)

NC_000964.3 - Region 5 - NRPS,betalactone
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 1,940,625 - 2,017,660 nt. (total: 77,036 nt) Show pHMM detection rules used
NRPS: cds(Condensation and (AMP-binding or A-OX))
betalactone: (HMGL-like and AMP-binding)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
NRPS/PKS domains
MIBiG comparison
KnownClusterBlast
NRPS/PKS modules
Pfam domains
TIGRFAM domains
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
A glossary is available here.
Selected features only
Show module domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | NRPS | betalactone | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | --- | ---
BGC0000407.1 |  |  | 1.01 | NRP | plipastatin | Bacillus subtilis subsp. subtilis
BGC0001095.1 |  |  | 0.77 | NRP | fengycin | Bacillus velezensis FZB42
BGC0001103.1 |  |  | 0.67 | NRP, Polyketide | mycosubtilin | Bacillus subtilis subsp. spizizenii ATCC 6633
BGC0001615.1 |  |  | 0.65 | NRP | hexose-palythine-serine, hexose-shinorine | Heteroscytonema crispum UCFS10
BGC0000389.1 |  |  | 0.62 | NRP | massetolide A | Pseudomonas fluorescens SS101
BGC0001833.1 |  |  | 0.58 | NRP | icosalide A, icosalide B | Burkholderia gladioli
BGC0001844.1 |  |  | 0.57 | NRP | holrhizin | Paraburkholderia rhizoxinica HKI 454
BGC0000426.1 |  |  | 0.57 | NRP | sevadicin | Paenibacillus larvae
BGC0001890.1 |  |  | 0.55 | NRP | amphi-enterobactin 1, amphi-enterobactin 2, amphi-enterobactin 3, amphi-enterobactin 4 | Vibrio campbellii ATCC BAA-1116
BGC0001758.1 |  |  | 0.55 | NRP | rhizomide A, rhizomide B, rhizomide C | Paraburkholderia rhizoxinica HKI 454

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000407.1 |  | 0.93 | NRP | plipastatin | Bacillus subtilis subsp. subtilis
BGC0001095.1 |  | 0.82 | NRP | fengycin | Bacillus velezensis FZB42
BGC0000389.1 |  | 0.74 | NRP | massetolide A | Pseudomonas fluorescens SS101
BGC0001103.1 |  | 0.74 | NRP, Polyketide | mycosubtilin | Bacillus subtilis subsp. spizizenii ATCC 6633
BGC0001434.1 |  | 0.70 | NRP | nematophin | Xenorhabdus budapestensis
BGC0001698.1 |  | 0.70 | NRP | nevaltophin A, nevaltophin B, nevaltophin C, nevaltophin D | Xenorhabdus budapestensis
BGC0001050.1 |  | 0.70 | NRP, Polyketide | thalassospiramide A | Tistrella bauzanensis
BGC0001833.1 |  | 0.68 | NRP | icosalide A, icosalide B | Burkholderia gladioli
BGC0000426.1 |  | 0.68 | NRP | sevadicin | Paenibacillus larvae
BGC0001844.1 |  | 0.67 | NRP | holrhizin | Paraburkholderia rhizoxinica HKI 454

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.
Module view
Shows module structures for each candidate in NRPS- and PKS regions. Genes are shown in predicted order, and are only present when containing at least one complete module. A domain glossary is available here.
Legend
Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
NRPS/PKS products
NRPS/PKS monomers
Predicted core structure(s)
Shows estimated product structure and polymer for each candidate cluster in the region. To show the product, click on the expander or the candidate cluster feature drawn in the overview.
For candidate cluster 6, location 1940624 - 2017660:
Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:
  (glu - D-orn) + (tyr - D-thr) + (glu - D-val) + (pro - glu - D-tyr) + (ile)

Direct lookup in NORINE database: strict or relaxed
Link to NORINE database query form
NRPS/PKS monomer predictions
Shows the predicted monomers for each adynelation domain and acyltransferase within genes. Each gene prediction can be expanded to view detailed predictions of each domain. Each prediction can be expanded to view the predictions by tool (and, for some tools, further expanded for extra details).

ctg1_1886: X
  Search NORINE for peptide: strict or relaxed
  AMP-binding (13..445): X
  NRPSPredictor2: (unknown)
  SVM prediction details:
    NOTE: outside applicability domain
    Predicted physicochemical class:
      N/A
    Large clusters prediction:
      asp, asn, glu, gln, aad
    Small clusters prediction:
      N/A
    Single AA prediction:
      N/A
  Stachelhaus prediction details:
    Stachelhaus sequence:
      gclhIAApvK
    Nearest Stachelhaus code:
      phe
    Stachelhaus code match:
      40% (weak)
ctg1_1891: ile
  Search NORINE for peptide: strict or relaxed
  AMP-binding (474..867): ile
  NRPSPredictor2: ile
  SVM prediction details:
    Predicted physicochemical class:
      hydrophobic-aliphatic
    Large clusters prediction:
      gly, ala, val, leu, ile, abu, iva
    Small clusters prediction:
      val, leu, ile, abu, iva
    Single AA prediction:
      ile
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DAFFYGITFK
    Nearest Stachelhaus code:
      ile
    Stachelhaus code match:
      100% (strong)
ctg1_1892: pro - glu - tyr
  Search NORINE for peptide: strict or relaxed
  AMP-binding (468..865): pro
  NRPSPredictor2: pro
  SVM prediction details:
    Predicted physicochemical class:
      hydrophobic-aliphatic
    Large clusters prediction:
      pro, pip
    Small clusters prediction:
      pro
    Single AA prediction:
      pro
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DVQFIAHVVK
    Nearest Stachelhaus code:
      pro
    Stachelhaus code match:
      100% (strong)
  AMP-binding (1499..1900): glu
  NRPSPredictor2: glu
  SVM prediction details:
    Predicted physicochemical class:
      hydrophilic
    Large clusters prediction:
      asp, asn, glu, gln, aad
    Small clusters prediction:
      glu, gln
    Single AA prediction:
      glu
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DAWHFGSVEK
    Nearest Stachelhaus code:
      glu
    Stachelhaus code match:
      100% (strong)
  AMP-binding (2538..2932): tyr
  NRPSPredictor2: tyr
  SVM prediction details:
    Predicted physicochemical class:
      hydrophobic-aromatic
    Large clusters prediction:
      phe, trp, phg, tyr, bht
    Small clusters prediction:
      tyr, bht
    Single AA prediction:
      tyr
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DGTITAEVAK
    Nearest Stachelhaus code:
      tyr
    Stachelhaus code match:
      100% (strong)
ctg1_1893: glu - val
  Search NORINE for peptide: strict or relaxed
  AMP-binding (469..870): glu
  NRPSPredictor2: glu
  SVM prediction details:
    Predicted physicochemical class:
      hydrophilic
    Large clusters prediction:
      asp, asn, glu, gln, aad
    Small clusters prediction:
      glu, gln
    Single AA prediction:
      glu
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DAWHFGGVDK
    Nearest Stachelhaus code:
      glu
    Stachelhaus code match:
      100% (strong)
  AMP-binding (1510..1903): val
  NRPSPredictor2: val
  SVM prediction details:
    Predicted physicochemical class:
      hydrophobic-aliphatic
    Large clusters prediction:
      gly, ala, val, leu, ile, abu, iva
    Small clusters prediction:
      val, leu, ile, abu, iva
    Single AA prediction:
      val
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DVFWIGGTFK
    Nearest Stachelhaus code:
      val
    Stachelhaus code match:
      100% (strong)
ctg1_1894: tyr - thr
  Search NORINE for peptide: strict or relaxed
  AMP-binding (474..865): tyr
  NRPSPredictor2: tyr
  SVM prediction details:
    Predicted physicochemical class:
      hydrophobic-aromatic
    Large clusters prediction:
      phe, trp, phg, tyr, bht
    Small clusters prediction:
      tyr, bht
    Single AA prediction:
      tyr
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DGTITAEVAK
    Nearest Stachelhaus code:
      tyr
    Stachelhaus code match:
      100% (strong)
  AMP-binding (1505..1903): thr
  NRPSPredictor2: thr
  SVM prediction details:
    Predicted physicochemical class:
      hydrophobic-aliphatic
    Large clusters prediction:
      ser, thr, dhpg, hpg
    Small clusters prediction:
      thr
    Single AA prediction:
      thr
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DFWNIGMVHK
    Nearest Stachelhaus code:
      thr
    Stachelhaus code match:
      100% (strong)
ctg1_1895: glu - orn
  Search NORINE for peptide: strict or relaxed
  AMP-binding (463..864): glu
  NRPSPredictor2: glu
  SVM prediction details:
    Predicted physicochemical class:
      hydrophilic
    Large clusters prediction:
      asp, asn, glu, gln, aad
    Small clusters prediction:
      glu, gln
    Single AA prediction:
      glu
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DAWHFGGVDK
    Nearest Stachelhaus code:
      glu
    Stachelhaus code match:
      100% (strong)
  AMP-binding (1503..1908): orn
  NRPSPredictor2: orn
  SVM prediction details:
    Predicted physicochemical class:
      hydrophilic
    Large clusters prediction:
      orn, lys, arg
    Small clusters prediction:
      orn, horn
    Single AA prediction:
      orn
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DVGEIGSIDK
    Nearest Stachelhaus code:
      orn
    Stachelhaus code match:
      100% (strong)

NC_000964.3 - Region 6 - terpene
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 2,092,168 - 2,114,066 nt. (total: 21,899 nt) Show pHMM detection rules used
terpene: (Terpene_synth or Terpene_synth_C or phytoene_synt or Lycopene_cycl or terpene_cyclase or NapT7 or fung_ggpps or fung_ggpps2 or trichodiene_synth or TRI5)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
MIBiG comparison
KnownClusterBlast
Pfam domains
TIGRFAM domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | terpene | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001120.1 |  | 0.16 | NRP, Polyketide | burkholderic acid | Burkholderia thailandensis E264
BGC0001925.1 |  | 0.15 | Alkaloid | altemicidin, SB-203207, SB-203208 | Streptomyces sp.
BGC0001535.1 |  | 0.14 | Other | branched-chain fatty acids | Streptomyces filamentosus
BGC0000313.1 |  | 0.11 | NRP | beauvericin | Beauveria bassiana
BGC0000663.1 |  | 0.08 | Terpene | hopene | Streptomyces coelicolor A3(2)
BGC0001575.1 |  | 0.06 | NRP | dipeptide aldehydes | Ruminococcus sp. 5_1_39BFAA
BGC0001739.1 |  | 0.05 | Other | phosphonoacetic Acid | Streptomyces sp. NRRL F-525
BGC0001338.1 |  | 0.05 | Polyketide | citrinin | Monascus ruber
BGC0000154.1 |  | 0.05 | Polyketide | stipitatic acid | Talaromyces stipitatus ATCC 10500
BGC0001207.1 |  | 0.05 | NRP | teixobactin | Eleftheria terrae

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001120.1 |  | 0.47 | NRP, Polyketide | burkholderic acid | Burkholderia thailandensis E264
BGC0001925.1 |  | 0.44 | Alkaloid | altemicidin, SB-203207, SB-203208 | Streptomyces sp.
BGC0001535.1 |  | 0.44 | Other | branched-chain fatty acids | Streptomyces filamentosus
BGC0000313.1 |  | 0.38 | NRP | beauvericin | Beauveria bassiana
BGC0000663.1 |  | 0.30 | Terpene | hopene | Streptomyces coelicolor A3(2)
BGC0001575.1 |  | 0.26 | NRP | dipeptide aldehydes | Ruminococcus sp. 5_1_39BFAA
BGC0001739.1 |  | 0.23 | Other | phosphonoacetic Acid | Streptomyces sp. NRRL F-525
BGC0001338.1 |  | 0.21 | Polyketide | citrinin | Monascus ruber
BGC0000154.1 |  | 0.21 | Polyketide | stipitatic acid | Talaromyces stipitatus ATCC 10500
BGC0001207.1 |  | 0.21 | NRP | teixobactin | Eleftheria terrae

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.

No matches found.

Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
NC_000964.3 - Region 7 - glycocin
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 2,259,521 - 2,279,691 nt. (total: 20,171 nt) Show pHMM detection rules used
glycocin: (glycocin or sublancin)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
MIBiG comparison
KnownClusterBlast
Pfam domains
TIGRFAM domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | glycocin | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000558.1 |  | 0.83 | RiPP | sublancin 168 | Bacillus subtilis subsp. subtilis str. 168
BGC0001861.1 |  | 0.30 | RiPP | bacillicin BAG2O | Bacillus cereus BAG2O-1
BGC0001863.1 |  | 0.29 | RiPP, Terpene | bacillicn CER074 | Bacillus mycoides
BGC0001930.1 |  | 0.24 | RiPP | pallidocin | Aeribacillus pallidus
BGC0001862.1 |  | 0.23 | RiPP | geocillicin | Aeribacillus pallidus
BGC0001210.1 |  | 0.15 | RiPP | pseudomycoicidin | Bacillus pseudomycoides DSM 12442
BGC0000561.1 |  | 0.13 | RiPP | thermophilin 1277 | Streptococcus thermophilus
BGC0000617.1 |  | 0.13 | RiPP | coagulin | Bacillus coagulans
BGC0000497.1 |  | 0.13 | RiPP | BHT-Aα, BHT-Aβ | Streptococcus ratti
BGC0000543.1 |  | 0.12 | RiPP | pep5 | Staphylococcus epidermidis

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000558.1 |  | 0.94 | RiPP | sublancin 168 | Bacillus subtilis subsp. subtilis str. 168
BGC0001861.1 |  | 0.64 | RiPP | bacillicin BAG2O | Bacillus cereus BAG2O-1
BGC0001863.1 |  | 0.63 | RiPP, Terpene | bacillicn CER074 | Bacillus mycoides
BGC0001930.1 |  | 0.57 | RiPP | pallidocin | Aeribacillus pallidus
BGC0001862.1 |  | 0.56 | RiPP | geocillicin | Aeribacillus pallidus
BGC0001210.1 |  | 0.45 | RiPP | pseudomycoicidin | Bacillus pseudomycoides DSM 12442
BGC0000561.1 |  | 0.42 | RiPP | thermophilin 1277 | Streptococcus thermophilus
BGC0000617.1 |  | 0.42 | RiPP | coagulin | Bacillus coagulans
BGC0000497.1 |  | 0.41 | RiPP | BHT-Aα, BHT-Aβ | Streptococcus ratti
BGC0000543.1 |  | 0.40 | RiPP | pep5 | Staphylococcus epidermidis

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.
Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
NC_000964.3 - Region 8 - T3PKS
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 2,296,956 - 2,338,053 nt. (total: 41,098 nt) Show pHMM detection rules used
T3PKS: (Chal_sti_synt_C or Chal_sti_synt_N)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
NRPS/PKS domains
MIBiG comparison
KnownClusterBlast
Pfam domains
TIGRFAM domains
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
A glossary is available here.
Selected features only
Show module domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | T3PKS | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000282.1 |  | 0.24 | Polyketide | alkylresorcinol | Streptomyces griseus subsp. griseus NBRC 13350
BGC0001938.1 |  | 0.23 | Polyketide | entotheonella | Candidatus Entotheonella serta
BGC0001962.1 |  | 0.23 | Polyketide | hierridin B, hierridin C | Cyanobium sp. LEGE 06113
BGC0001831.1 |  | 0.19 | Polyketide | alkylpyrone-407, alkylpyrone-393 | Myxococcus xanthus DK 1622
BGC0001475.1 |  | 0.17 | Polyketide | aspterric acid | Aspergillus terreus NIH2624
BGC0001928.1 |  | 0.16 | Other | (2R,3S,4S)-5-fluoro-2,3,4-trihydroxypentanoic acid | Streptomyces sp. MA37
BGC0001882.1 |  | 0.14 | Polyketide | chrysoxanthone A, chrysoxanthone B, chrysoxanthone C | Penicillium rubens Wisconsin 54-1255
BGC0001735.1 |  | 0.14 | Other | pentostatine, vidarabine | Streptomyces antibioticus
BGC0000509.1 |  | 0.13 | RiPP | epilancin 15x | Staphylococcus epidermidis
BGC0001686.1 |  | 0.13 | NRP | N-octanoyl-Met-Phe-H | Clostridium sp. CAG:567

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000282.1 |  | 0.58 | Polyketide | alkylresorcinol | Streptomyces griseus subsp. griseus NBRC 13350
BGC0001938.1 |  | 0.57 | Polyketide | entotheonella | Candidatus Entotheonella serta
BGC0001962.1 |  | 0.56 | Polyketide | hierridin B, hierridin C | Cyanobium sp. LEGE 06113
BGC0001831.1 |  | 0.52 | Polyketide | alkylpyrone-407, alkylpyrone-393 | Myxococcus xanthus DK 1622
BGC0001475.1 |  | 0.49 | Polyketide | aspterric acid | Aspergillus terreus NIH2624
BGC0001928.1 |  | 0.47 | Other | (2R,3S,4S)-5-fluoro-2,3,4-trihydroxypentanoic acid | Streptomyces sp. MA37
BGC0001882.1 |  | 0.43 | Polyketide | chrysoxanthone A, chrysoxanthone B, chrysoxanthone C | Penicillium rubens Wisconsin 54-1255
BGC0001735.1 |  | 0.43 | Other | pentostatine, vidarabine | Streptomyces antibioticus
BGC0000509.1 |  | 0.42 | RiPP | epilancin 15x | Staphylococcus epidermidis
BGC0001686.1 |  | 0.41 | NRP | N-octanoyl-Met-Phe-H | Clostridium sp. CAG:567

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.

No matches found.

Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
NC_000964.3 - Region 9 - NRPS
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 3,260,519 - 3,307,655 nt. (total: 47,137 nt) Show pHMM detection rules used
NRPS: cds(Condensation and (AMP-binding or A-OX))

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
NRPS/PKS domains
MIBiG comparison
KnownClusterBlast
NRPS/PKS modules
Pfam domains
TIGRFAM domains
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
A glossary is available here.
Selected features only
Show module domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | NRPS | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000309.1 |  | 1.00 | NRP | bacillibactin | Bacillus subtilis subsp. subtilis str. 168
BGC0001185.1 |  | 0.58 | NRP | bacillibactin | Bacillus velezensis FZB42
BGC0000401.1 |  | 0.55 | NRP | paenibactin | Paenibacillus elgii B69
BGC0000457.1 |  | 0.29 | NRP | vicibactin | Rhizobium etli CFN 42
BGC0001833.1 |  | 0.28 | NRP | icosalide A, icosalide B | Burkholderia gladioli
BGC0001132.1 |  | 0.28 | NRP | xenotetrapeptide | Xenorhabdus nematophila ATCC 19061
BGC0001825.1 |  | 0.27 | NRP | xenematide | Xenorhabdus nematophila AN6/1
BGC0001844.1 |  | 0.27 | NRP | holrhizin | Paraburkholderia rhizoxinica HKI 454
BGC0001758.1 |  | 0.27 | NRP | rhizomide A, rhizomide B, rhizomide C | Paraburkholderia rhizoxinica HKI 454
BGC0001128.1 |  | 0.27 | NRP | luminmide | Photorhabdus laumondii subsp. laumondii TTO1

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000309.1 |  | 1.00 | NRP | bacillibactin | Bacillus subtilis subsp. subtilis str. 168
BGC0001185.1 |  | 0.83 | NRP | bacillibactin | Bacillus velezensis FZB42
BGC0000401.1 |  | 0.82 | NRP | paenibactin | Paenibacillus elgii B69
BGC0000457.1 |  | 0.63 | NRP | vicibactin | Rhizobium etli CFN 42
BGC0001833.1 |  | 0.62 | NRP | icosalide A, icosalide B | Burkholderia gladioli
BGC0001132.1 |  | 0.61 | NRP | xenotetrapeptide | Xenorhabdus nematophila ATCC 19061
BGC0001825.1 |  | 0.61 | NRP | xenematide | Xenorhabdus nematophila AN6/1
BGC0001844.1 |  | 0.61 | NRP | holrhizin | Paraburkholderia rhizoxinica HKI 454
BGC0001758.1 |  | 0.60 | NRP | rhizomide A, rhizomide B, rhizomide C | Paraburkholderia rhizoxinica HKI 454
BGC0001128.1 |  | 0.60 | NRP | luminmide | Photorhabdus laumondii subsp. laumondii TTO1

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.
Module view
Shows module structures for each candidate in NRPS- and PKS regions. Genes are shown in predicted order, and are only present when containing at least one complete module. A domain glossary is available here.
Legend
Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
NRPS/PKS products
NRPS/PKS monomers
Predicted core structure(s)
Shows estimated product structure and polymer for each candidate cluster in the region. To show the product, click on the expander or the candidate cluster feature drawn in the overview.
For candidate cluster 10, location 3260518 - 3307655:
Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:
  (gly - thr)

Direct lookup in NORINE database: strict or relaxed
Link to NORINE database query form
NRPS/PKS monomer predictions
Shows the predicted monomers for each adynelation domain and acyltransferase within genes. Each gene prediction can be expanded to view detailed predictions of each domain. Each prediction can be expanded to view the predictions by tool (and, for some tools, further expanded for extra details).

ctg1_3297: gly - thr
  Search NORINE for peptide: strict or relaxed
  AMP-binding (463..861): gly
  NRPSPredictor2: gly
  SVM prediction details:
    Predicted physicochemical class:
      hydrophobic-aliphatic
    Large clusters prediction:
      gly, ala, val, leu, ile, abu, iva
    Small clusters prediction:
      gly, ala
    Single AA prediction:
      gly
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DILQLGLIWK
    Nearest Stachelhaus code:
      gly
    Stachelhaus code match:
      100% (strong)
  AMP-binding (1519..1935): thr
  NRPSPredictor2: thr
  SVM prediction details:
    Predicted physicochemical class:
      hydrophobic-aliphatic
    Large clusters prediction:
      ser, thr, dhpg, hpg
    Small clusters prediction:
      thr
    Single AA prediction:
      thr
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DFWNIGMVHK
    Nearest Stachelhaus code:
      thr
    Stachelhaus code match:
      100% (strong)
ctg1_3299: dhb
  Search NORINE for peptide: strict or relaxed
  AMP-binding (31..435): dhb
  NRPSPredictor2: dhb
  SVM prediction details:
    Predicted physicochemical class:
      hydrophobic-aromatic
    Large clusters prediction:
      dhb, sal
    Small clusters prediction:
      dhb, sal
    Single AA prediction:
      dhb
  Stachelhaus prediction details:
    Stachelhaus sequence:
      PLPAQGVVNK
    Nearest Stachelhaus code:
      dhb
    Stachelhaus code match:
      100% (strong)

NC_000964.3 - Region 10 - CDPS
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 3,593,821 - 3,614,567 nt. (total: 20,747 nt) Show pHMM detection rules used
CDPS: (CDPS or cycdipepsynth)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
MIBiG comparison
KnownClusterBlast
Pfam domains
TIGRFAM domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | CDPS | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001891.1 |  | 0.17 | Other | closthioamide | Ruminiclostridium cellulolyticum H10
BGC0001607.1 |  | 0.16 | Other | gilvusmycin | Streptomyces sp. NRRL B-1347
BGC0001540.1 |  | 0.15 | Other | CC-1065 | Streptomyces zelensis
BGC0001140.1 |  | 0.13 | Terpene | platensimycin, platencin | Streptomyces platensis
BGC0002009.1 |  | 0.13 | Polyketide | kanglemycin A, kanglemycin V1, kanglemycin V2 | Amycolatopsis vancoresmycina
BGC0001782.1 |  | 0.10 | Other | spiroindimicin A, spiroindimicin B, spiroindimicin C, spiroindimicin D, indimicin A, indimicin B, indimicin C, indimicin D, indimicin E, lynamicin A, lynamicin D, lynamicin F, lynamicin G | Streptomyces sp. SCSIO 03032
BGC0001335.1 |  | 0.10 | Alkaloid | borregomycin A, borregomycin B, borregomycin C, borregomycin D | uncultured bacterium
BGC0001334.1 |  | 0.09 | Alkaloid | caldoniamide A, cladoniamide B, cladoniamide C7, cladoniamide D, cladoniamide E, cladoniamide F, cladoniamide G | Streptomyces uncialis
BGC0000845.1 |  | 0.08 | Other (Non-NRP beta-lactam) | clavulanic acid | Streptomyces clavuligerus ATCC 27064
BGC0000469.1 |  | 0.08 | RiPP | bottromycin A2 | Streptomyces sp. BC16019

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001891.1 |  | 0.48 | Other | closthioamide | Ruminiclostridium cellulolyticum H10
BGC0001607.1 |  | 0.46 | Other | gilvusmycin | Streptomyces sp. NRRL B-1347
BGC0001540.1 |  | 0.45 | Other | CC-1065 | Streptomyces zelensis
BGC0001140.1 |  | 0.42 | Terpene | platensimycin, platencin | Streptomyces platensis
BGC0002009.1 |  | 0.41 | Polyketide | kanglemycin A, kanglemycin V1, kanglemycin V2 | Amycolatopsis vancoresmycina
BGC0001782.1 |  | 0.35 | Other | spiroindimicin A, spiroindimicin B, spiroindimicin C, spiroindimicin D, indimicin A, indimicin B, indimicin C, indimicin D, indimicin E, lynamicin A, lynamicin D, lynamicin F, lynamicin G | Streptomyces sp. SCSIO 03032
BGC0001335.1 |  | 0.35 | Alkaloid | borregomycin A, borregomycin B, borregomycin C, borregomycin D | uncultured bacterium
BGC0001334.1 |  | 0.33 | Alkaloid | caldoniamide A, cladoniamide B, cladoniamide C7, cladoniamide D, cladoniamide E, cladoniamide F, cladoniamide G | Streptomyces uncialis
BGC0000845.1 |  | 0.32 | Other (Non-NRP beta-lactam) | clavulanic acid | Streptomyces clavuligerus ATCC 27064
BGC0000469.1 |  | 0.31 | RiPP | bottromycin A2 | Streptomyces sp. BC16019

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.

No matches found.

Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
NC_000964.3 - Region 11 - sactipeptide
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 3,826,058 - 3,847,669 nt. (total: 21,612 nt) Show pHMM detection rules used
sactipeptide: (subtilosin or thuricin or TIGR04404 or Subtilosin_A or skfc)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
MIBiG comparison
KnownClusterBlast
Sactipeptides
Pfam domains
TIGRFAM domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | sactipeptide | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000602.1 |  | 0.72 | RiPP | subtilosin A | Bacillus subtilis subsp. spizizenii ATCC 6633
BGC0000703.1 |  | 0.19 | Saccharide | kanamycin | Streptomyces kanamyceticus
BGC0001137.1 |  | 0.19 | Alkaloid | marinacarboline A, marinacarboline B, marinacarboline C, marinacarboline D | Marinactinospora thermotolerans
BGC0001496.1 |  | 0.17 | RiPP | actinokineosin | Actinokineospora spheciospongiae
BGC0001655.1 |  | 0.16 | RiPP | LP2006 | Nocardiopsis alba DSM 43377
BGC0000497.1 |  | 0.16 | RiPP | BHT-Aα, BHT-Aβ | Streptococcus ratti
BGC0000552.1 |  | 0.16 | RiPP | SmbA, SmbB | Streptococcus mutans
BGC0000568.1 |  | 0.15 | RiPP | microcin B17 | Escherichia coli
BGC0001311.1 |  | 0.15 | RiPP | flavecins | Ruminococcus flavefaciens FD-1
BGC0000522.1 |  | 0.15 | RiPP | lacticin Z | Lactococcus lactis

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000602.1 |  | 0.90 | RiPP | subtilosin A | Bacillus subtilis subsp. spizizenii ATCC 6633
BGC0000703.1 |  | 0.51 | Saccharide | kanamycin | Streptomyces kanamyceticus
BGC0001137.1 |  | 0.50 | Alkaloid | marinacarboline A, marinacarboline B, marinacarboline C, marinacarboline D | Marinactinospora thermotolerans
BGC0001496.1 |  | 0.48 | RiPP | actinokineosin | Actinokineospora spheciospongiae
BGC0001655.1 |  | 0.47 | RiPP | LP2006 | Nocardiopsis alba DSM 43377
BGC0000497.1 |  | 0.46 | RiPP | BHT-Aα, BHT-Aβ | Streptococcus ratti
BGC0000552.1 |  | 0.46 | RiPP | SmbA, SmbB | Streptococcus mutans
BGC0000568.1 |  | 0.46 | RiPP | microcin B17 | Escherichia coli
BGC0001311.1 |  | 0.46 | RiPP | flavecins | Ruminococcus flavefaciens FD-1
BGC0000522.1 |  | 0.46 | RiPP | lacticin Z | Lactococcus lactis

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.
Sactipeptide predictions
Lists the possible core peptides for each biosynthetic enzyme, including the predicted class. Each core peptide shows the leader and core peptide sequences, separated by a dash.

#### Putative Sactipeptide(s)

ctg1_3846 leader / core peptide
  MKKAVIVENK - GCATCSIGAACLVDGPIPDFEIAGATGLFGLWG

Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
Sactipeptides
Core peptide predictions
Lists the possible core peptides in the region. Each core peptide lists its RODEO score and predicted core sequence.

ctg1_3846
  Putative sactipeptide
  RODEO score: 33.0
  Core sequence, approximate: GCATCSIGAACLVDGPIPDFEIAGATGLFGLWG

NC_000964.3 - Region 12 - other
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 3,850,668 - 3,892,086 nt. (total: 41,419 nt) Show pHMM detection rules used
other: (LmbU or Neocarzinostat or fom1 or bcpB or frbD or mitE or vlmB or prnB or CaiA or bacilysin or orf2_PTase)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
MIBiG comparison
KnownClusterBlast
Pfam domains
TIGRFAM domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | other | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000888.1 |  | 0.59 | Other | bacilysin | Bacillus sp. CS93
BGC0001184.1 |  | 0.57 | Other | bacilysin | Bacillus velezensis FZB42
BGC0000813.1 |  | 0.27 | Alkaloid | K-252a | Nonomuraea longicatena
BGC0000907.1 |  | 0.24 | Other | lincomycin | Streptomyces lincolnensis
BGC0000699.1 |  | 0.22 | Saccharide | hygromycin A | Streptomyces hygroscopicus subsp. hygroscopicus
BGC0000214.1 |  | 0.21 | Polyketide | cosmomycin B | Streptomyces olindensis
BGC0000678.1 |  | 0.21 | Terpene | pentalenolactone | Streptomyces avermitilis MA-4680 = NBRC 14893
BGC0000720.1 |  | 0.20 | Saccharide | tobramycin | Streptoalloteichus tenebrarius
BGC0000702.1 |  | 0.20 | Saccharide | kanamycin | Streptomyces kanamyceticus
BGC0000827.1 |  | 0.20 | Alkaloid | staurosporine | Salinispora arenicola CNS-205

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000888.1 |  | 0.83 | Other | bacilysin | Bacillus sp. CS93
BGC0001184.1 |  | 0.82 | Other | bacilysin | Bacillus velezensis FZB42
BGC0000813.1 |  | 0.60 | Alkaloid | K-252a | Nonomuraea longicatena
BGC0000907.1 |  | 0.57 | Other | lincomycin | Streptomyces lincolnensis
BGC0000699.1 |  | 0.55 | Saccharide | hygromycin A | Streptomyces hygroscopicus subsp. hygroscopicus
BGC0000214.1 |  | 0.54 | Polyketide | cosmomycin B | Streptomyces olindensis
BGC0000678.1 |  | 0.53 | Terpene | pentalenolactone | Streptomyces avermitilis MA-4680 = NBRC 14893
BGC0000720.1 |  | 0.53 | Saccharide | tobramycin | Streptoalloteichus tenebrarius
BGC0000702.1 |  | 0.52 | Saccharide | kanamycin | Streptomyces kanamyceticus
BGC0000827.1 |  | 0.52 | Alkaloid | staurosporine | Salinispora arenicola CNS-205

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.
Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
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NC_000964.3 - Region 13 - RRE-containing
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
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Location: 4,088,150 - 4,108,419 nt. (total: 20,270 nt) Show pHMM detection rules used
RRE-containing: minimum(1, [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE, Cytolysin_C_RRE, Goadsporin_CD_RRE, Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE, Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE, Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE, Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE, Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE, Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE, Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE, Thiaglutamate_B_RRE, Thiaglutamate_G_RRE, Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE, Thurincin_rSAM_RRE, Trifolitoxin_RRE])

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
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Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
MIBiG comparison
KnownClusterBlast
Pfam domains
TIGRFAM domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | RRE-containing | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000888.1 |  | 0.29 | Other | bacilysin | Bacillus sp. CS93
BGC0000885.1 |  | 0.26 | Other | 4-hydroxy-3-nitrosobenzamide | Streptomyces murayamaensis
BGC0001184.1 |  | 0.25 | Other | bacilysin | Bacillus velezensis FZB42
BGC0000937.1 |  | 0.23 | Other | fosfazinomycin A | Streptomyces sp. WM6372
BGC0000678.1 |  | 0.21 | Terpene | pentalenolactone | Streptomyces avermitilis MA-4680 = NBRC 14893
BGC0001739.1 |  | 0.19 | Other | phosphonoacetic Acid | Streptomyces sp. NRRL F-525
BGC0000845.1 |  | 0.16 | Other (Non-NRP beta-lactam) | clavulanic acid | Streptomyces clavuligerus ATCC 27064
BGC0000667.1 |  | 0.16 | Terpene | PR-toxin | Penicillium roqueforti FM164
BGC0001928.1 |  | 0.15 | Other | (2R,3S,4S)-5-fluoro-2,3,4-trihydroxypentanoic acid | Streptomyces sp. MA37
BGC0001241.1 |  | 0.15 | Terpene | ergotamine | Claviceps fusiformis

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000888.1 |  | 0.63 | Other | bacilysin | Bacillus sp. CS93
BGC0000885.1 |  | 0.60 | Other | 4-hydroxy-3-nitrosobenzamide | Streptomyces murayamaensis
BGC0001184.1 |  | 0.59 | Other | bacilysin | Bacillus velezensis FZB42
BGC0000937.1 |  | 0.56 | Other | fosfazinomycin A | Streptomyces sp. WM6372
BGC0000678.1 |  | 0.53 | Terpene | pentalenolactone | Streptomyces avermitilis MA-4680 = NBRC 14893
BGC0001739.1 |  | 0.51 | Other | phosphonoacetic Acid | Streptomyces sp. NRRL F-525
BGC0000845.1 |  | 0.47 | Other (Non-NRP beta-lactam) | clavulanic acid | Streptomyces clavuligerus ATCC 27064
BGC0000667.1 |  | 0.46 | Terpene | PR-toxin | Penicillium roqueforti FM164
BGC0001928.1 |  | 0.46 | Other | (2R,3S,4S)-5-fluoro-2,3,4-trihydroxypentanoic acid | Streptomyces sp. MA37
BGC0001241.1 |  | 0.45 | Terpene | ergotamine | Claviceps fusiformis

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.

No matches found.

Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
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Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
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NC_000964.3 - Region 14 - epipeptide
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
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Location: 4,115,742 - 4,137,440 nt. (total: 21,699 nt) Show pHMM detection rules used
epipeptide: (TIGR04078 and yydH)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
MIBiG comparison
KnownClusterBlast
Pfam domains
TIGRFAM domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | epipeptide | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000758.1 |  | 0.21 | Saccharide | capsular polysaccharide | Staphylococcus aureus
BGC0000788.1 |  | 0.20 | Saccharide | O-antigen | Salmonella enterica subsp. salamae serovar Greenside
BGC0000791.1 |  | 0.20 | Saccharide | O-antigen | Cronobacter sakazakii
BGC0000732.1 |  | 0.19 | Saccharide | capsular polysaccharide | Raoultella planticola
BGC0000733.1 |  | 0.19 | Saccharide | capsular polysaccharide | Klebsiella pneumoniae
BGC0000730.1 |  | 0.19 | Saccharide | capsular polysaccharide | Klebsiella pneumoniae
BGC0000731.1 |  | 0.19 | Saccharide | capsular polysaccharide | Klebsiella pneumoniae
BGC0000728.1 |  | 0.19 | Saccharide | capsular polysaccharide | Klebsiella pneumoniae subsp. ozaenae
BGC0000729.1 |  | 0.19 | Saccharide | capsular polysaccharide | Klebsiella pneumoniae
BGC0001639.1 |  | 0.16 | RiPP | klebsidin | Klebsiella pneumoniae

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000758.1 |  | 0.53 | Saccharide | capsular polysaccharide | Staphylococcus aureus
BGC0000788.1 |  | 0.52 | Saccharide | O-antigen | Salmonella enterica subsp. salamae serovar Greenside
BGC0000791.1 |  | 0.52 | Saccharide | O-antigen | Cronobacter sakazakii
BGC0000732.1 |  | 0.52 | Saccharide | capsular polysaccharide | Raoultella planticola
BGC0000733.1 |  | 0.52 | Saccharide | capsular polysaccharide | Klebsiella pneumoniae
BGC0000730.1 |  | 0.52 | Saccharide | capsular polysaccharide | Klebsiella pneumoniae
BGC0000731.1 |  | 0.52 | Saccharide | capsular polysaccharide | Klebsiella pneumoniae
BGC0000728.1 |  | 0.52 | Saccharide | capsular polysaccharide | Klebsiella pneumoniae subsp. ozaenae
BGC0000729.1 |  | 0.52 | Saccharide | capsular polysaccharide | Klebsiella pneumoniae
BGC0001639.1 |  | 0.46 | RiPP | klebsidin | Klebsiella pneumoniae

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.
Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names