LOCUS       c00039_NZ_JALS..       10618 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  NZ_JALS01000039.1 Geobacillus stearothermophilus ATCC 7953
            GBScontig0000021_3, whole genome shotgun sequence.
ACCESSION   NZ_JALS01000039
VERSION     NZ_JALS01000039
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 6.1.1
            Run date     :: 2024-03-14 14:31:02
            Original ID  :: NZ_JALS01000039.1
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 13825
            Orig. end    :: 24443
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..10618
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[18825:19443](-)"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193)"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(5001..5618)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193)"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
     cand_cluster    1..10618
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193)"
                     /kind="single"
                     /product="RiPP-like"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..10618
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="RiPP-like"
                     /region_number="1"
                     /rules="(strepbact or Antimicrobial14 or Bacteriocin_IId or
                     BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or
                     Lactococcin or Antimicrobial17 or Lactococcin_972 or
                     Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or
                     TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or
                     TIGR03975 or DUF692 or TIGR01193)"
                     /tool="antismash"
     CDS             758..1894
                     /locus_tag="ctg39_16"
                     /transl_table=11
                     /translation="VRFLRELTVFPQTLPIPGKDSRRSLAEREEWIMTISLVKRPIMDP
                     EAPNRSTGIINGRCSNVLNWDDIAYPWAYAKYKRMLANFWTPFEINMAQDVKQFPQLTA
                     REQDAFLKIIGLLALLDSIQTDYAGRVADYITDPSINALMIMLAQQEVIHNHSYSYVLS
                     SLVPKAKQDEVFDFWRNEPTLRKRNDFVTNGYKAFAEEPNVENLLRSIVFDVILEGLFF
                     YSGFAFFYNLARQQKMVATSTMINYINRDEHIHVDLFTKIFKEVLNEYPEYRTPELADF
                     VRNTFMKAAELEIEWAREIIGNDIDGIDLADLEAYIKFYANVRAHQLGFDRPFDGYRTN
                     PLRWIKAYEEVDLGKSDFFEQKPRQYTKVQVDNGFDEL"
     PFAM_domain     944..1780
                     /aSDomain="Ribonuc_red_sm"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00268.23"
                     /description="Ribonucleotide reductase, small chain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg39_16_0001"
                     /evalue="5.40E-74"
                     /label="ctg39_16"
                     /locus_tag="ctg39_16"
                     /protein_end="341"
                     /protein_start="62"
                     /score="249.2"
                     /tool="antismash"
                     /translation="LNWDDIAYPWAYAKYKRMLANFWTPFEINMAQDVKQFPQLTAREQ
                     DAFLKIIGLLALLDSIQTDYAGRVADYITDPSINALMIMLAQQEVIHNHSYSYVLSSLV
                     PKAKQDEVFDFWRNEPTLRKRNDFVTNGYKAFAEEPNVENLLRSIVFDVILEGLFFYSG
                     FAFFYNLARQQKMVATSTMINYINRDEHIHVDLFTKIFKEVLNEYPEYRTPELADFVRN
                     TFMKAAELEIEWAREIIGNDIDGIDLADLEAYIKFYANVRAHQLGFDRPFDGYRTNP"
     CDS             2095..2247
                     /locus_tag="ctg39_17"
                     /transl_table=11
                     /translation="VGKKQEIERLREQLNQWLVEEEHDNDEVWLKRGGSDFSTFRSAGF
                     KRHRL"
     CDS             3086..3268
                     /locus_tag="ctg39_18"
                     /transl_table=11
                     /translation="MVCIVLCRWRASSPPDERVSCFRSEHTLFVAMFRVCSRGMATSRQ
                     AVKQYPRVALFRADG"
     CDS             complement(3225..3761)
                     /locus_tag="ctg39_19"
                     /transl_table=11
                     /translation="MRTVTLTDVFAHPIAQKYLKRSGLAHAITAAYHAYHLALRHGVNV
                     DLATKAALLHDIGHYTWYKNGRWDYEQYRQNDIHAIKGAERAHKLLIRLGEHPQNAKEI
                     ALAILLHTDSYLPEGEWKRTPLQAIVKWADEADEEPGGRHHYRTISDDLAWKKIRQLDE
                     LVSRQHGKERLGDIV"
     PFAM_domain     complement(3357..3692)
                     /aSDomain="HD"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF01966.24"
                     /description="HD domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg39_19_0002"
                     /evalue="3.40E-14"
                     /label="ctg39_19"
                     /locus_tag="ctg39_19"
                     /protein_end="135"
                     /protein_start="23"
                     /score="53.2"
                     /tool="antismash"
                     /translation="LAHAITAAYHAYHLALRHGVNVDLATKAALLHDIGHYTWYKNGRW
                     DYEQYRQNDIHAIKGAERAHKLLIRLGEHPQNAKEIALAILLHTDSYLPEGEWKRTPLQ
                     AIVKWADE"
     aSDomain        complement(3489..3698)
                     /aSDomain="TIGR00277"
                     /aSTool="tigrfam"
                     /description="HDIG: HDIG domain"
                     /detection="hmmscan"
                     /domain_id="TIGRFam_ctg39_19_0001"
                     /evalue="8.90E-09"
                     /identifier="TIGR00277"
                     /label="ctg39_19"
                     /locus_tag="ctg39_19"
                     /protein_end="91"
                     /protein_start="21"
                     /score="33.1"
                     /tool="antismash"
                     /translation="SGLAHAITAAYHAYHLALRHGVNVDLATKAALLHDIGHYTWYKNG
                     RWDYEQYRQNDIHAIKGAERAHKLL"
     CDS             complement(4321..4674)
                     /locus_tag="ctg39_20"
                     /transl_table=11
                     /translation="VDGFPFISDVVQLTDFFMFGRGNDANVVDVDNHPISLLGHKADRV
                     ILSAQLIDMNDTGVSVFFAGAETEKCSFDGAADFSLVGQNRFHIAQSVHRNAHGVSPLS
                     LAKMAFSQFLLLL"
     CDS             complement(4690..4950)
                     /locus_tag="ctg39_21"
                     /transl_table=11
                     /translation="MGQSVRRRFNSHIRCLQQSKRPADLQTAGRLASWPSSRAGCLVLN
                     VRNEQRQFRTERLNTDVIDNHFRFLPKMDGIAALINIEQPF"
     CDS             complement(5001..5618)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: Linocin_M18"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg39_22"
                     /sec_met_domain="Linocin_M18 (E-value: 1.6e-66, bitscore:
                     215.4, seeds: 61, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="VHLTIPLLYKDFILYWRDIEQAKQLGSPIDFSAAANAAQQCALLE
                     DDLIFNGSAEFDVPGIMNVEGKIAHIRSDWMKSGNAFADVVEARNKLLQLGHTGPYALV
                     LSPELYALIHRIHEGTHVLEIEHIRELMTAGIYQTPVIKGKRGVVIDAGRQNIDLAVAV
                     DVQTSFLDTENMNYLFRVYESVVPRIKRPSAICTLEDPAGAS"
     PFAM_domain     complement(5064..5615)
                     /aSDomain="Linocin_M18"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF04454.14"
                     /description="Encapsulating protein for peroxidase"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg39_22_0003"
                     /evalue="9.80E-65"
                     /label="ctg39_22"
                     /locus_tag="ctg39_22"
                     /protein_end="185"
                     /protein_start="1"
                     /score="218.5"
                     /tool="antismash"
                     /translation="HLTIPLLYKDFILYWRDIEQAKQLGSPIDFSAAANAAQQCALLED
                     DLIFNGSAEFDVPGIMNVEGKIAHIRSDWMKSGNAFADVVEARNKLLQLGHTGPYALVL
                     SPELYALIHRIHEGTHVLEIEHIRELMTAGIYQTPVIKGKRGVVIDAGRQNIDLAVAVD
                     VQTSFLDTENMNYLFRVYESV"
     CDS             5655..5885
                     /locus_tag="ctg39_23"
                     /transl_table=11
                     /translation="VEAHVPLFRVHINIVGDRLDTFAERTVQIDKPTSDELAARRFNDQ
                     FLKLAPLACCERGFWIQLRFIHVSSPFLSVF"
     CDS             complement(5871..6473)
                     /locus_tag="ctg39_24"
                     /transl_table=11
                     /translation="LHDAHDALAEVSVILGRSKEALGQFQAILEPTIEQAVDDHERLYW
                     HHIYEEEEHRFDRLAALLPKLEEALADEAFLSRENGDFLRLLQDISLEKFGLHNFLEHL
                     DLSLFHYKGTEHEPAIAALRDMTAADYQQMKAALETLNRALDAPLSFDASVPTDEKEHQ
                     KDHLKLAQYAVPPSDPAPVRPSIGTRRQLTVGSLKHG"
     aSDomain        complement(5877..6458)
                     /aSDomain="TIGR04536"
                     /aSTool="tigrfam"
                     /description="geobac_encap: encapsulated protein"
                     /detection="hmmscan"
                     /domain_id="TIGRFam_ctg39_24_0002"
                     /evalue="7.90E-79"
                     /identifier="TIGR04536"
                     /label="ctg39_24"
                     /locus_tag="ctg39_24"
                     /protein_end="199"
                     /protein_start="5"
                     /score="262.0"
                     /tool="antismash"
                     /translation="DALAEVSVILGRSKEALGQFQAILEPTIEQAVDDHERLYWHHIYE
                     EEEHRFDRLAALLPKLEEALADEAFLSRENGDFLRLLQDISLEKFGLHNFLEHLDLSLF
                     HYKGTEHEPAIAALRDMTAADYQQMKAALETLNRALDAPLSFDASVPTDEKEHQKDHLK
                     LAQYAVPPSDPAPVRPSIGTRRQLTVGSLKH"
     CDS             complement(6614..6847)
                     /locus_tag="ctg39_25"
                     /transl_table=11
                     /translation="MGGAPVTSALGSTAKPEIALAMLMAPFKSAWRVYPHLWHRKRFVS
                     RFHFKCDRNSQVPFLSPCNDYMISFFFIIIQL"
     CDS             7278..8261
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1158:ornithine cyclodeaminase (Score: 286.2; E-value:
                     4.1e-87)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg39_26"
                     /transl_table=11
                     /translation="MLILSEQEIQRMYTMKDAISDVKEMLRQKQAGKVITPDRTVLPFP
                     NHDASILYMPSAEEGAAVVKVVSIFPHNPAAGRSTTQGIMVLTDAKTGEHRMVCNATYL
                     TRLRTGALSAIAADYLATQAASRLAVIGTGAMAKEQVVGILAVRAIERIFLYNRTRKKA
                     EDLAAGLHQLVREWTGKVYVVDEADEAVRQADIVVCSTRSEQPVFSSQMLRPGMHISAI
                     GSYLPHMRELDVETIVQADRIVVDTLEGVRHEAGELIQAAESGRWSFSQIDAEIGELVT
                     GEKAGRQHDQEITLFKSVGAAFYDLAVAIGVYQKAKELGVGQEIEL"
     PFAM_domain     7284..8231
                     /aSDomain="OCD_Mu_crystall"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF02423.17"
                     /description="Ornithine cyclodeaminase/mu-crystallin
                     family"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg39_26_0004"
                     /evalue="6.30E-70"
                     /label="ctg39_26"
                     /locus_tag="ctg39_26"
                     /protein_end="318"
                     /protein_start="2"
                     /score="235.7"
                     /tool="antismash"
                     /translation="ILSEQEIQRMYTMKDAISDVKEMLRQKQAGKVITPDRTVLPFPNH
                     DASILYMPSAEEGAAVVKVVSIFPHNPAAGRSTTQGIMVLTDAKTGEHRMVCNATYLTR
                     LRTGALSAIAADYLATQAASRLAVIGTGAMAKEQVVGILAVRAIERIFLYNRTRKKAED
                     LAAGLHQLVREWTGKVYVVDEADEAVRQADIVVCSTRSEQPVFSSQMLRPGMHISAIGS
                     YLPHMRELDVETIVQADRIVVDTLEGVRHEAGELIQAAESGRWSFSQIDAEIGELVTGE
                     KAGRQHDQEITLFKSVGAAFYDLAVAIGVYQKAKE"
     CDS             complement(8216..8530)
                     /locus_tag="ctg39_27"
                     /transl_table=11
                     /translation="MFRTFHRSVSPSSLIPCRLAAFIPHRFHYRRNRAAYQVGNVPYSV
                     LFGTGPKGDVGWKRTKNRTGNRPENGFLFLAKMAETKQHILIPIPYNSISCPTPSSFAF
                     "
     aSDomain        8588..9418
                     /aSDomain="TIGR00179"
                     /aSTool="tigrfam"
                     /description="murB: UDP-N-acetylenolpyruvoylglucosamine
                     reductase"
                     /detection="hmmscan"
                     /domain_id="TIGRFam_ctg39_28_0003"
                     /evalue="2.40E-72"
                     /identifier="TIGR00179"
                     /label="ctg39_28"
                     /locus_tag="ctg39_28"
                     /protein_end="277"
                     /protein_start="0"
                     /score="241.6"
                     /tool="antismash"
                     /translation="MKNHTLVRIGGKADFLVWPETYEQVIEVLRLKEEYGLPFTLLGNG
                     SNVIIRDGGLRGIVMQLKHLNRIWREGNNVIAQSGADIKAVSRFALEQHLTGLEFACGI
                     PGSVGGAIMMNAGAYGGEVKDVLDHVKVATLAGELKTLTNEELELGYRTSIISRTHDIV
                     LEVVFSLQPGDYAQIKAKMDDLTFQRESKQPLEYPSVGSVFKRPPGYFAGKLIQDSGLQ
                     GKGFGGAEVSTKHAGFIINKNNATAADYIATIDMVRKTVKEKFGVDLELEVKIIG"
     CDS             8588..9427
                     /locus_tag="ctg39_28"
                     /transl_table=11
                     /translation="MKNHTLVRIGGKADFLVWPETYEQVIEVLRLKEEYGLPFTLLGNG
                     SNVIIRDGGLRGIVMQLKHLNRIWREGNNVIAQSGADIKAVSRFALEQHLTGLEFACGI
                     PGSVGGAIMMNAGAYGGEVKDVLDHVKVATLAGELKTLTNEELELGYRTSIISRTHDIV
                     LEVVFSLQPGDYAQIKAKMDDLTFQRESKQPLEYPSVGSVFKRPPGYFAGKLIQDSGLQ
                     GKGFGGAEVSTKHAGFIINKNNATAADYIATIDMVRKTVKEKFGVDLELEVKIIGEE"
     PFAM_domain     8627..9013
                     /aSDomain="FAD_binding_4"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF01565.25"
                     /description="FAD binding domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg39_28_0005"
                     /evalue="1.60E-25"
                     /label="ctg39_28"
                     /locus_tag="ctg39_28"
                     /protein_end="142"
                     /protein_start="13"
                     /score="89.5"
                     /tool="antismash"
                     /translation="DFLVWPETYEQVIEVLRLKEEYGLPFTLLGNGSNVIIRDGGLRGI
                     VMQLKHLNRIWREGNNVIAQSGADIKAVSRFALEQHLTGLEFACGIPGSVGGAIMMNAG
                     AYGGEVKDVLDHVKVATLAGELKTL"
     PFAM_domain     9116..9415
                     /aSDomain="MurB_C"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF02873.18"
                     /description="UDP-N-acetylenolpyruvoylglucosamine
                     reductase, C-terminal domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg39_28_0006"
                     /evalue="2.30E-31"
                     /label="ctg39_28"
                     /locus_tag="ctg39_28"
                     /protein_end="276"
                     /protein_start="176"
                     /score="108.4"
                     /tool="antismash"
                     /translation="QIKAKMDDLTFQRESKQPLEYPSVGSVFKRPPGYFAGKLIQDSGL
                     QGKGFGGAEVSTKHAGFIINKNNATAADYIATIDMVRKTVKEKFGVDLELEVKII"
     CDS             9525..9647
                     /locus_tag="ctg39_29"
                     /transl_table=11
                     /translation="VPDGAFANSVGCGFDAHIARMANRSAWKGRFNRVGLRAWS"
     CDS             9644..9895
                     /locus_tag="ctg39_30"
                     /transl_table=11
                     /translation="MKRRFLERDVFSLFQWITVGFALRDGLLAAIKAYLIVRYDVEAFD
                     RAIVIREGIGWGITILCMLGFVRISKIISERENRHHST"
ORIGIN
        1 gcgttttggc gcggctgatc ccgattcaaa tgcggatgct cgataatgtc attgatttaa
       61 acaatatccc tgtgctgcaa gccggcctga cgaacgaaaa ataccgcgct gtcgggcttg
      121 gaacctttgg ctggcatcat ttgttggcgt taaaaggcat tcgctgggag tcggacgaag
      181 cggtccgcta tgccgacgag ctgtatgaaa cgatcgcgta tttggcgatt caagcgagca
      241 tggagctcgc caaagagaaa gggagctacc cggcgtttcc ggggtcggac tggcagacag
      301 gcgcttattt tgagcggcgc ggctacgaaa gccacggtga attggattgg gatcggctga
      361 agcaagacgt ggcccgctat gggatgcgaa acggctatgt gatggcggtg gcgccgaacg
      421 cctcgacgtc gatcatcgcc ggcagtacag cgagcattga cccgattttc ttaaaagtgt
      481 acgccgagga aaagaaagat tataagattc ccgttacggt gccggattta aacgaacaga
      541 cgacatggta ttacaaatcg gcgtaccata tcgaccagcg ctggagcatc aagcaaaacg
      601 ccgcccgcca gcgccatgtc gaccaagcca tctcctttaa cttctacgtc gtgaacacga
      661 ttaaggcaaa agagctgctc gatttgcatt tgacggcgtg gaagtcgggg ctgaaaacga
      721 cgtattacgt gcgttcgaca tcggggacga tcgacgagtg cgattcttgc gcgagctgac
      781 ggtcttcccc cagacgttgc cgattccggg gaaagattca cgccgaagct tagctgaaag
      841 ggaggaatgg atcatgacaa tcagcttagt caaacggccg attatggatc cagaggcgcc
      901 gaaccgttcg acgggcatta tcaacggccg ctgctcgaat gtgttgaact gggacgatat
      961 cgcctaccca tgggcgtatg cgaaatataa gcgaatgctc gccaactttt ggacgccgtt
     1021 tgaaatcaat atggcccaag atgtgaagca gtttccgcag ctgaccgccc gcgagcagga
     1081 tgcgtttttg aaaatcattg gactcttggc gctgcttgac agcatccaaa ccgactacgc
     1141 cggacgtgtc gctgattaca ttacggaccc gagcatcaat gcgctcatga tcatgctcgc
     1201 ccagcaggaa gtcattcaca accattccta ttcgtacgtg ctctcgagcc ttgtgccgaa
     1261 agcaaagcaa gatgaagtat tcgacttttg gcgaaacgaa ccgacgctac gcaagcggaa
     1321 cgattttgtg acgaacggct acaaggcgtt tgccgaagag ccgaacgtgg agaacttgct
     1381 gcggtcgatc gtctttgacg ttattttaga aggattgttt ttctactcgg ggttcgcctt
     1441 tttctacaac ctcgcgcgcc agcaaaaaat ggtggcgacg agcacgatga tcaattacat
     1501 caaccgtgac gagcacattc atgttgattt gtttacaaaa attttcaagg aagtgttgaa
     1561 cgaataccca gagtatcgga cgccggagct tgccgatttc gtccggaaca cgtttatgaa
     1621 agcggcagag ctggaaatcg aatgggctcg ggaaatcatt gggaatgaca tcgatggcat
     1681 cgacttggct gatttggaag cgtacattaa gttttacgcc aacgtccgcg cccaccagct
     1741 cggatttgac cgcccgtttg acggctaccg gacgaacccg ctccgctgga ttaaagcgta
     1801 tgaagaagtt gaccttggca aatcagactt cttcgagcaa aaaccacgcc agtatacgaa
     1861 agtacaagtc gataatgggt ttgatgagct gtaaggaaac ccgcgttggg gcatcgtcca
     1921 acgcggtttt ttgccggaaa acatgattaa cggagggatt ctcgctgcat tatacaatgg
     1981 ggaagagaaa aggaaaagag atgttgcggt ttgttgtcgg acggtaggct tgggcgcctt
     2041 accttggtat aatgagaaaa aacttgcttt tgaatgcgaa aggggacggg agaagtgggg
     2101 aaaaaacagg aaatcgaacg gctgcgcgag caattgaatc agtggctcgt ggaagaggag
     2161 cacgacaatg acgaggtatg gctgaagagg gggggaagcg atttttcaac gtttcgctca
     2221 gctgggttca agcgccatcg cctataacca gcttggcgac ccggaaacgt cgcttgccat
     2281 acttgaccag cttgaagggt atcacggccc gggacagcct aaccattatg aacggatcac
     2341 cgtgaccgcc atagatgctg atggcgagaa gtacacgtgt tacacgtacg tgtacccatc
     2401 agaacgaaaa gagtggcttg agcaacacgc caaacaagtt tttggaggtg attggatggt
     2461 gtttctccat tccaaagatg aagtgatgta ctttgcctat ggctcttgca tgagcgaacg
     2521 cgattttcgc tgcactgtcc cgcattttga ggtgatgggc cgagcggtgc ttgacgatca
     2581 ccggttggcg ttcacccggt attcccgcgg tcggcaagga ggggtcgcag atatcgtccc
     2641 ttctccgggc gaccgggtcg aaggcgtgct gtacaaaatt ccggcgcgct atgtgacgga
     2701 acttgattgg cgcgagggcg tcccagccgg cgtgtaccgt cgtgaatacg tcgatgtgca
     2761 gtgtaaggga cagcttgttt ccgccctcac gtacgttgtc gtcgagaaac agttggatga
     2821 aatcgcgcca agcgaatcgt acgcttcgat tattcttgat gaaggggcat ctcttttaag
     2881 cacgcattac accgagcggg tgcggcgtca tattgaacat ttacggagaa gagagcggta
     2941 agtgcaggaa aacggtgcgt tgcggcggtg ctccaaggct tgccgttttt ttttgggaag
     3001 aacggcggcg ggcgttttgg cgggacagat ggtgccaagc agtcttaaag cgtgagtgga
     3061 cgatgaggat ataagagggc attcgatggt gtgtatcgtt ctgtgtcgct ggcgcgcgag
     3121 cagcccacct gatgaaaggg tgagctgttt ccgttcagag catacattgt tcgtggcgat
     3181 gtttcgcgtc tgttcaaggg gaatggcgac atcaaggcaa gcggtcaaac aatatccccg
     3241 agtcgctctt ttccgtgctg acggctgacg agttcgtcga gctggcggat ttttttccac
     3301 gctaagtcgt cgctgatcgt tcgataatgg tggcggccgc cgggctcctc gtcggcttcg
     3361 tcggcccatt tgacgatggc ttgaagcggc gttcgtttcc attctccttc tggaaggtag
     3421 gaatcggtat gaagcaaaat cgccagggca atttccttag cgttttgcgg atgttcgcca
     3481 aggcggatca gcagcttatg ggcgcgctcg gcccctttga tggcatggat gtcgttttgc
     3541 cggtattgtt cgtagtccca acggccgttt ttgtaccatg tgtaatggcc gatatcatga
     3601 agcagtgccg cttttgtcgc caagtcgacg ttcactccgt ggcggagggc aaggtggtag
     3661 gcatggtacg ccgcggtgat ggcgtgggcg aggccggatc gttttaaata tttttgcgca
     3721 atcggatggg caaagacgtc ggttaaggtg accgttctca taggcatccc ctccgttttt
     3781 tgtatttctc accatcatac catggcgtaa agagtcaggc aatgagagaa agtaggtggg
     3841 agcggttgca tgggaaaaaa taagccgatc gtgctaaaat agcgctcggc ttattggatt
     3901 tgtgcttggc aggcaagccg tttggctggt tgatccgttt tttcgcgctc gcgccgcgtt
     3961 ttcggagcga gaaggtgagc gccggccaga acggtgacca tgcaacggcc acacgttcct
     4021 tttttgcatt tgtgatcgag cagaacacct tgtcctaggg cggcgtcaag aagcgaaacg
     4081 ccgggggctg gctgcacggt gaacgttttc cctttttgtt cgatttgaat gacagacggc
     4141 cgcacggcgg acggcccatc gggcttaggc ggcgcggcag aaatggagcg ctccgatggc
     4201 cggacggcag gcttcagtga gccgaccgtg aatgttttac ccattttttt acacatctcc
     4261 tttaaattac atggttagtt tgaaaatgaa tctcatttac atccgaatga atgattggta
     4321 tcataatagt aaaaggaatt gcgaaaacgc catcttggct agggacaagg gggagacacc
     4381 atgggcattc cgatgaacgg actgcgcgat atgaaagcga ttttggccaa cgagcgaaaa
     4441 gtcggcggcg ccatcgaagc tgcatttctc cgtctccgct ccggcgaaga ataccgaaac
     4501 gcctgtatcg ttcatatcga tcagctgggc gctcaatatt actctgtcgg ctttgtgacc
     4561 gagcaaggag atcggatggt tgtcaacgtc cacgacatta gcgtcatttc cgcgcccgaa
     4621 cataaaaaaa tccgtgagct gaacaacgtc gcttataaac gggaagccat ccacaacaag
     4681 cggcgctatt taaaacggct gttcgatatt tatcaaggca gctataccgt ccatttttgg
     4741 caggaagcga aaatgattat cgatgacatc ggtgttgagg cgctcagtcc ggaattgtcg
     4801 ctgctcgttt cgaacgttca agaccaagca gcccgcacgg cttgatggcc aactagcaag
     4861 acgcccagcg gtttgtaaat ccgctgggcg tttcgattgt tgcaagcagc ggatgtggct
     4921 attgaatcgc cttcggacgc tttggcccat gtctagccag cctcccgcta atgtgtcccc
     4981 tctttccctg aaaagagaaa ttacgaggct ccggctggat cttcaagcgt acagatggcg
     5041 ctcggccgtt taatgcgcgg cacaaccgat tcatagacac ggaacaagta gttcatgttt
     5101 tccgtatcta aaaacgaggt ttgcacgtcg acagcgacag caagatcgat gttttgtcgg
     5161 ccggcatcga taacgacgcc gcgtttgcct ttaatgactg gcgtttggta aatgccggcg
     5221 gtcatcagct cgcggatgtg ctcaatttca agcacgtgcg ttccttcatg gatgcggtgg
     5281 atcaacgcat acaactccgg tgacaggacg agtgcgtatg ggccggtatg gccgagctga
     5341 agcagcttgt tgcgcgcttc aacgacgtcg gcgaaggcgt tgcccgattt catccagtcg
     5401 ctgcgaatgt gggcgatttt tccttccacg ttcataatgc ccggtacatc aaattcagcc
     5461 gaaccgttga aaatcaaatc gtcctcgagc agcgcgcact gctgggcggc gttggcagcg
     5521 gcggaaaagt cgatcgggct gccaagctgt tttgcctgct caatgtcgcg ccagtacaaa
     5581 ataaagtctt tatacaaaag cgggatcgtt aaatgcacgc ggcgcgccgg ctcggaaagg
     5641 ctcagctctt tgccgtggaa gctcatgtcc ccctgttccg ggttcatata aatatcgttg
     5701 gcgaccgact ggacaccttc gccgagcgga ccgtacaaat cgataaacct acgtccgacg
     5761 agctggcggc gcgccgtttc aatgaccagt tcctcaagct cgctccattg gcttgctgtg
     5821 agcggggctt ctggatacag cttcgtttta tccatgtttc ctctcctttc ttatccgtgt
     5881 tttaagctgc cgactgtcag ttgccgtctc gttccgatcg atgggcggac aggtgctggg
     5941 tcggaaggag ggacagcgta ctgagccagt ttcaaatggt ctttttgatg ctctttttcg
     6001 tccgtcggca ctgaagcgtc gaaagacaat ggcgcatcga gcgcacggtt gagcgtttcg
     6061 agagcggctt tcatctgttg gtagtccgcc gcggtcatgt cgcgcagcgc cgcaatcgcc
     6121 ggttcatgtt ccgtcccttt ataatgaaac aacgacaaat cgagatgctc caaaaagttg
     6181 tgcaagccga atttttctag gctgatgtct tgcaacaggc gcagaaagtc gccgttttcc
     6241 cgcgataaga acgcttcgtc cgccaatgcc tcctccaact ttggaagcag ggcggccaaa
     6301 cggtcaaatc ggtgctcctc ttcttcgtaa atatgatgcc aatacagccg ttcatgatca
     6361 tcaaccgcct gttcaattgt cggctctaaa atcgcttgaa actggccgag cgcctctttc
     6421 gaccggccga gaatgacgct gacctctgct aatgcgtcgt gtgcgtcgtg caatggactc
     6481 cctcccatga aatggttgtt accatttttt ccatatgtat atgattgtaa aactctttgc
     6541 tctcgtccgc attacagatc agcgagcgag aaagcccact ccttgagggg gggatgaaag
     6601 cgagccgttt tcttcataat tgaatgatga tgaaaaaaaa cgatatcatg taatcgttgc
     6661 aaggagaaag aaatggtact tggctgttgc ggtcacattt gaagtggaac cgcgacacga
     6721 aacgcttccg atgccaaagg tgtggataca ctctccacgc cgacttgaat ggcgccatca
     6781 acatcgccaa agcgatttcg ggctttgccg tcgaacctag cgcactggtc acaggtgcgc
     6841 cgcccattgg ggtacatcct aacccgatgg gacggggtga tgatacatcc cgaagctttt
     6901 gcgttgtccg aaccagaaat ggatgaggac gcaaacgacc caagaatccc acgcctttag
     6961 gcgtgcggag tgtcaacgct gtgcttggta caatgttttc agaaattttc ccatctaacg
     7021 tccgatatac gggtatttcg cttggctacc aaatcggcgc cgcactagcg ggaggaacgg
     7081 caccgctcat cgctacggca ttgctggcgg cgtatgggaa ctcttatgtg ccggtggcct
     7141 tatatattgt attagtctcg cttatttcgc tggccgctgt ctggtctgtg cgcgaccgca
     7201 aacatgaaga acttgatgag caagacggaa tcgcgtaacg cggttccgtt ttttcagcgt
     7261 attgaaggag ggggattatg cttattttgt cagaacaaga aattcaacgc atgtatacga
     7321 tgaaggatgc catttccgat gtaaaagaaa tgttgcgaca aaaacaagca gggaaagtga
     7381 tcacccctga tcgcacggtg cttccatttc cgaatcatga tgcttcgatt ttgtatatgc
     7441 catccgctga ggagggggca gcagtggtga aggtggtcag cattttcccc cataaccctg
     7501 cagcaggaag atcgaccacc caggggatca tggtgcttac ggatgcgaaa acgggggaac
     7561 atcggatggt ttgtaatgcc acgtatttga cgagactgcg cacgggggcg ttatccgcca
     7621 ttgcagctga ttatttggcg acacaggcgg cgtcgcggct agcggtgatc ggaacagggg
     7681 cgatggccaa agaacaagtg gttggcatat tggcagtgag agcgattgaa cgtatatttc
     7741 tgtacaaccg aacgaggaaa aaagcagaag acttggcggc gggactgcat caactggttc
     7801 gggaatggac agggaaggta tatgtggtgg atgaggcgga cgaagccgtt cgccaggccg
     7861 acatcgtggt atgcagcacg cgctcggaac agccggtgtt ttccagtcaa atgttgcggc
     7921 caggcatgca cattagcgcc attggctcgt acttgccaca tatgcgcgag ttggatgtgg
     7981 agactattgt ccaagcggac cgcattgtcg tcgatacact tgagggcgtc aggcatgagg
     8041 caggagaact cattcaggcg gctgaaagtg gaagatggtc tttttctcaa attgatgccg
     8101 aaatcgggga actcgtcacc ggagagaaag ctgggcggca acacgatcag gaaatcacct
     8161 tatttaaatc ggtcggagcg gctttctatg atttggctgt ggcgattggc gtctatcaaa
     8221 aagcgaagga gctcggagta ggacaagaaa tagaattata ggggatggga atgaggatat
     8281 gctgctttgt ttctgccatt ttggcgagaa acaggaatcc attttccgga cggttgcccg
     8341 tccggttttt tgttcttttc catccgacgt caccttttgg cccagtcccg aataaaacag
     8401 aataaggaac attgcccact tgatatgcgg cgcgattccg gcgataatgg aaacgatgtg
     8461 gaatgaatgc cgccaagcgg catggaatga gagaagaagg tgagacagaa cgatgaaacg
     8521 tgcggaacat atttatcaaa gactcgtaga gatttgtggg gaaagaaacg tcctgcgcga
     8581 tgagccgatg aaaaaccata cattagtgcg gatcggcggc aaggctgatt ttctcgtctg
     8641 gccggaaacg tacgagcaag tcatcgaggt gttgcggctg aaagaggagt acggcctgcc
     8701 gtttaccctt ctcggcaacg gttcgaacgt catcatccgc gacggcgggc tgcgcggcat
     8761 tgtcatgcag ctgaagcatc tcaaccgcat ttggcgtgaa ggaaacaacg tgatcgccca
     8821 aagcggggcg gatattaaag cggtgtcgcg gttcgcgctc gaacaacacc tcaccgggtt
     8881 ggagttcgcc tgcggcattc cggggtcggt cggcggggcg attatgatga acgccggagc
     8941 gtacggcggg gaagtgaaag atgtgcttga ccatgtcaag gtggcgacgc tcgccggcga
     9001 gttgaaaaca ttgacaaacg aggaactgga gctcggttat cgaacaagca tcatcagccg
     9061 gacgcatgat attgtgcttg aagtcgtctt ttccctgcag ccgggcgact atgcacaaat
     9121 caaggcgaaa atggatgatt taacatttca gcgcgaatcg aaacagccgc ttgagtatcc
     9181 gtcggtcggc agcgtgttta agcggccgcc gggctatttt gccggcaagc tcatccaaga
     9241 cagcggcctt cagggaaaag gattcggcgg tgcggaagtg tcgacgaaac acgccggatt
     9301 catcattaac aaaaacaatg cgacggctgc cgattacatc gcgacgatcg acatggtgcg
     9361 caaaaccgta aaggagaagt tcggagttga tttagagctg gaagtgaaaa ttatcggtga
     9421 ggaatgatga ctgatccgaa tccggtttgc gggttcggat ttttcttatt tcgccgagag
     9481 gaaaaatgaa acaaaccgcc aataggtaag aaaagggatt atccgtgccc gacggcgcgt
     9541 ttgccaacag cgtcggctgc ggttttgacg cccatatcgc ccgcatggcc aaccgttcgg
     9601 catggaaagg gcggttcaat cgtgttgggc tccgcgcttg gtcatgaaaa gacggttttt
     9661 ggaacgtgat gtcttttcac tttttcaatg gatcactgtt ggttttgctt tgcgcgatgg
     9721 gctgttggcg gcgattaagg cgtacttgat cgttcgctac gacgtcgaag cgtttgaccg
     9781 tgcgattgtc attcgcgaag gcattggttg ggggatcacg attctctgta tgttggggtt
     9841 tgtccgtatt tcgaaaatca tctcggagcg ggagaaccgc catcattcga cgtgagcgta
     9901 aaggagagaa gcggtcgaaa gcaaaacggg caactgaaga aacagggaaa agggagcggc
     9961 gttgcacatg gccaaacgcc aagagggtgt cccaaaagga tcaggacacc ccctttcgtc
    10021 tctctatata cggcattgac cgcttcttcc gcactatatt tcgtgtctat cttgaagtca
    10081 gacagccttt tgggtcagcc cctttctcat catgaacctc ccccacttat cgaagtgggg
    10141 gtttcctgtt tccccttcgg aggtggatgc atgataggct ggttggcagc ctatctgcag
    10201 gcaacacctg gcacccgtcc cgttgggagc cacaggcaac atgagtatcc atgatactca
    10261 agggcgggaa ctcgccatct acgacttcat acctaagcaa tccgtcaata cgtaaacggt
    10321 ttgaccgtaa attccaatgg gcggatttca ccataatata ctttggcaaa taaattcatt
    10381 gccccatgga tatcacggtg tcgtttgtac ccgcattgac atgtatatgt ttggtgggag
    10441 tttgtttttg cgatgagcgc ccggcagggg aaaacgggat ggccaatgcc atgccgggcg
    10501 aaaacgaaag gagcaaaccg gttatgacgg agcgggtgga tgatattgtt gaggtttgtt
    10561 tattagcggg aaaattgatg cttgaaagcg gtggggagac gtaccgggtg gaagatac
//
