LOCUS       c00005_NZ_JALS..       10231 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  NZ_JALS01000005.1 Geobacillus stearothermophilus ATCC 7953
            GBScontig0000002_2, whole genome shotgun sequence.
ACCESSION   NZ_JALS01000005
VERSION     NZ_JALS01000005
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 6.1.1
            Run date     :: 2024-03-14 14:31:02
            Original ID  :: NZ_JALS01000005.1
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 21602
            Orig. end    :: 31833
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..10231
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[26602:26833](-)"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193)"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(5001..5231)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193)"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
     cand_cluster    1..10231
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193)"
                     /kind="single"
                     /product="RiPP-like"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..10231
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="RiPP-like"
                     /region_number="1"
                     /rules="(strepbact or Antimicrobial14 or Bacteriocin_IId or
                     BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or
                     Lactococcin or Antimicrobial17 or Lactococcin_972 or
                     Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or
                     TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or
                     TIGR03975 or DUF692 or TIGR01193)"
                     /tool="antismash"
     CDS             complement(767..1894)
                     /gene_functions="transport (smcogs) SMCOG1000:ABC
                     transporter ATP-binding protein (Score: 236.3; E-value:
                     5.8e-72)"
                     /gene_kind="transport"
                     /locus_tag="ctg5_29"
                     /transl_table=11
                     /translation="LHFPLSYVLIRNSEHQEDGGLEVNGEEIIRFERVTKEYDGTVVLD
                     DVSFAMERGKFYTLLGPSGCGKTTILRLIAGFIEPTEGTIYFHGKPIQNVPPNKRQVNT
                     VFQDYALFPHLDVFENVAFGLRVKKMKETDIREKVRESLRFVNLDGYERRRIQEMSGGQ
                     RQRVAIARAIVNEPEVLLLDEPLSALDLKLRTEMQYELRELQRRLGITFIFVTHDQEEA
                     LAMSDYIFVLNKGKIQQFGTPKDIYDEPVNRFVADFIGESNILSGRMIDDFLVEFAGKQ
                     FACVDRGFAPNEPVDVVIRPEDLELAAPEDGQIVIRVDSLLFRGVHYEICGYDENGNEW
                     LVHSTKKAEVGETVGLRFEPEAIHVMRLEKEDEDA"
     PFAM_domain     complement(797..1006)
                     /aSDomain="TOBE_2"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF08402.12"
                     /description="TOBE domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg5_29_0002"
                     /evalue="3.00E-09"
                     /label="ctg5_29"
                     /locus_tag="ctg5_29"
                     /protein_end="366"
                     /protein_start="296"
                     /score="37.0"
                     /tool="antismash"
                     /translation="VVIRPEDLELAAPEDGQIVIRVDSLLFRGVHYEICGYDENGNEWL
                     VHSTKKAEVGETVGLRFEPEAIHVM"
     aSDomain        complement(902..1720)
                     /aSDomain="TIGR01187"
                     /aSTool="tigrfam"
                     /description="potA: polyamine ABC transporter, ATP-binding
                     protein"
                     /detection="hmmscan"
                     /domain_id="TIGRFam_ctg5_29_0001"
                     /evalue="3.70E-108"
                     /identifier="TIGR01187"
                     /label="ctg5_29"
                     /locus_tag="ctg5_29"
                     /protein_end="331"
                     /protein_start="58"
                     /score="359.4"
                     /tool="antismash"
                     /translation="LLGPSGCGKTTILRLIAGFIEPTEGTIYFHGKPIQNVPPNKRQVN
                     TVFQDYALFPHLDVFENVAFGLRVKKMKETDIREKVRESLRFVNLDGYERRRIQEMSGG
                     QRQRVAIARAIVNEPEVLLLDEPLSALDLKLRTEMQYELRELQRRLGITFIFVTHDQEE
                     ALAMSDYIFVLNKGKIQQFGTPKDIYDEPVNRFVADFIGESNILSGRMIDDFLVEFAGK
                     QFACVDRGFAPNEPVDVVIRPEDLELAAPEDGQIVIRVDSLLFRGVHYEIC"
     PFAM_domain     complement(1337..1765)
                     /aSDomain="ABC_tran"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00005.29"
                     /description="ABC transporter"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg5_29_0001"
                     /evalue="1.40E-35"
                     /label="ctg5_29"
                     /locus_tag="ctg5_29"
                     /protein_end="186"
                     /protein_start="43"
                     /score="122.8"
                     /tool="antismash"
                     /translation="LDDVSFAMERGKFYTLLGPSGCGKTTILRLIAGFIEPTEGTIYFH
                     GKPIQNVPPNKRQVNTVFQDYALFPHLDVFENVAFGLRVKKMKETDIREKVRESLRFVN
                     LDGYERRRIQEMSGGQRQRVAIARAIVNEPEVLLLDEPL"
     CDS             complement(1951..2601)
                     /gene_functions="transport (smcogs) SMCOG1000:ABC
                     transporter ATP-binding protein (Score: 119; E-value:
                     4.3e-36)"
                     /gene_kind="transport"
                     /locus_tag="ctg5_30"
                     /transl_table=11
                     /translation="MEPLFSLQNLTYRYDGGATIFQQFSFSIFSGETVLLTGPNGVGKT
                     TLLHIISGLLDKGELHYQAFYKGNPIQLPDMRAHLSYVTSETVMFSKLTGYENIECFRL
                     LWKLDQQYVRKANELCSLLGMEEMLPLPVDQYSLGTKQKLHIAIALARPVKLYLMDEPF
                     NSLDRLSRDRLAEWIQGDRQHAYLIASHVHQERFPGSRIISLTRPNNEDKIEK"
     PFAM_domain     complement(2110..2538)
                     /aSDomain="ABC_tran"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00005.29"
                     /description="ABC transporter"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg5_30_0003"
                     /evalue="3.00E-23"
                     /label="ctg5_30"
                     /locus_tag="ctg5_30"
                     /protein_end="164"
                     /protein_start="21"
                     /score="83.0"
                     /tool="antismash"
                     /translation="QQFSFSIFSGETVLLTGPNGVGKTTLLHIISGLLDKGELHYQAFY
                     KGNPIQLPDMRAHLSYVTSETVMFSKLTGYENIECFRLLWKLDQQYVRKANELCSLLGM
                     EEMLPLPVDQYSLGTKQKLHIAIALARPVKLYLMDEPFN"
     CDS             complement(2791..3330)
                     /locus_tag="ctg5_31"
                     /transl_table=11
                     /translation="MLGALEEAFAVIRRAIHTHLPYMLLSLGVYIVCFAFGAVIFSQKL
                     TIHPTSMAFWTTLGHNLMVGAILMVGGWLTLGMANTLYLGYNAAMLGVIVRGVATGYGM
                     QPLMTGVFPHAIPEIIGHILFCTLGYETWRFLQIVKKRARGEEETLYIRDILFLLVLAV
                     ALLIISAWLESTVSHV"
     PFAM_domain     complement(2800..3249)
                     /aSDomain="SpoIIM"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF01944.19"
                     /description="Stage II sporulation protein M"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg5_31_0004"
                     /evalue="3.60E-18"
                     /label="ctg5_31"
                     /locus_tag="ctg5_31"
                     /protein_end="177"
                     /protein_start="27"
                     /score="66.2"
                     /tool="antismash"
                     /translation="GVYIVCFAFGAVIFSQKLTIHPTSMAFWTTLGHNLMVGAILMVGG
                     WLTLGMANTLYLGYNAAMLGVIVRGVATGYGMQPLMTGVFPHAIPEIIGHILFCTLGYE
                     TWRFLQIVKKRARGEEETLYIRDILFLLVLAVALLIISAWLESTVS"
     CDS             complement(3314..4729)
                     /locus_tag="ctg5_32"
                     /transl_table=11
                     /translation="MSVSPFIGVLLESKEALQRQYHYHYVRLSGVRDDEVWQRLLKIHY
                     AVSLLRLLPIWLPPSIGLMMMFGITGASFVWFGHTMLLLLYVTSHIVRGSTFRAIGAFS
                     AFFFRMASFAIGYVVLAAIVPLLQLSRQAVRMYGLSLSYLVYMDGYVAHWQQLFYERMT
                     SWREGWLFSSATLSFIGAGFALLALICFSFTRASHSDKTAYMLYSWHQRVIESLKIRST
                     NNAILYKDLCLLTRQARELTKPPWSLFLPGEWFLVAGANLALLPIVHNGSIILFLFMFE
                     MYIVMTGTLRAITDVFRDIFQFESEMERLTVFRLLSPPPLVPLIEAKWTLLERLGVYPC
                     MTAVGLLLLEYIGLLGMRGGLWAAMGAVVMMPVYSLVVKRILRTDYEVFCLVLASGEQA
                     ALTSPRDYAGYMVIAAGNHSFHRLLIYITVFSSLLSAFFMLLKGWSWACYSVLFVLMLY
                     LVLWNSSQYARRT"
     CDS             complement(5001..5231)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: Bacteriocin_IId"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg5_33"
                     /sec_met_domain="Bacteriocin_IId (E-value: 1.4e-32,
                     bitscore: 105.0, seeds: 5, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSLLALVAGTLGVSQSIATTVVSIVLTGSTLISIILGITAILSGG
                     VDVILEIGWSAFVATVKKIVAERGKAAAIAW"
     PFAM_domain     complement(5004..5210)
                     /aSDomain="Bacteriocin_IId"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF09221.12"
                     /description="Bacteriocin class IId cyclical
                     uberolysin-like"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg5_33_0005"
                     /evalue="1.00E-24"
                     /label="ctg5_33"
                     /locus_tag="ctg5_33"
                     /protein_end="76"
                     /protein_start="7"
                     /score="86.5"
                     /tool="antismash"
                     /translation="AGTLGVSQSIATTVVSIVLTGSTLISIILGITAILSGGVDVILEI
                     GWSAFVATVKKIVAERGKAAAIAW"
     aSDomain        complement(5004..5219)
                     /aSDomain="TIGR03651"
                     /aSTool="tigrfam"
                     /description="circ_ocin_uber: circular bacteriocin,
                     circularin A/uberolysin family"
                     /detection="hmmscan"
                     /domain_id="TIGRFam_ctg5_33_0002"
                     /evalue="2.70E-26"
                     /identifier="TIGR03651"
                     /label="ctg5_33"
                     /locus_tag="ctg5_33"
                     /protein_end="76"
                     /protein_start="4"
                     /score="89.7"
                     /tool="antismash"
                     /translation="ALVAGTLGVSQSIATTVVSIVLTGSTLISIILGITAILSGGVDVI
                     LEIGWSAFVATVKKIVAERGKAAAIAW"
     CDS             complement(5295..5465)
                     /locus_tag="ctg5_34"
                     /transl_table=11
                     /translation="VKQWSWPYFILISLPLVVLIGVAFRLKAASMPIKIGFIVLVLLYG
                     GVYSRLVRRMR"
     CDS             5767..6150
                     /locus_tag="ctg5_35"
                     /transl_table=11
                     /translation="LKSIKPGRVPSMQGLFGSIAAVLFGIFWMVMTFSITADSPFPAAR
                     FFPFFGLVVIAIGVFQAIYHYKNATGKQRMSLLDIVVSEEEPDPLNVRFGGKEKTNKYC
                     PYCGEHVQRDFQFCPRCGKAPSP"
     PFAM_domain     6070..6135
                     /aSDomain="zf-ribbon_3"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF13248.8"
                     /description="zinc-ribbon domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg5_35_0006"
                     /evalue="2.10E-06"
                     /label="ctg5_35"
                     /locus_tag="ctg5_35"
                     /protein_end="123"
                     /protein_start="101"
                     /score="27.0"
                     /tool="antismash"
                     /translation="KYCPYCGEHVQRDFQFCPRCGK"
     CDS             6457..8304
                     /locus_tag="ctg5_36"
                     /transl_table=11
                     /translation="VGLLDELKERILIADGAMGTLLYSHGIDRCFEELNLSNPDEIVHI
                     HEAYIAAGADVIQTNTYGANYVKLARYGLEDEVPAINRAAVRLARQAANGRAYVLGTIG
                     GLRTLNKSVVTLEEVKRTFREQLFVLLAEGVDGVLLETYYDLEELETVLAIARKETDLP
                     IIAHVSLHEVGVLQDGTPLADALIRLEALGADVVGLNCRLGPYHMLRSLEEVPLPKQAF
                     LSAYPNASLPDYRDGRLVYETNAEYFEETAKAFRDQGVRLIGGCCGTTPKHIEAMAKAL
                     ADRTPVTEKTVKRRTASVSVQADRPAPTPLPELARTYRSVIVELDPPKQLGIDKFLAGA
                     KALHDAGIDALTLADNSLATPRISNAAVATIIKEQLGIRPLVHITCRDRNLIGLQSHLM
                     GLHTLGITDVLAITGDPSKIGDFPGATSVYDLSSFDLIRLIRQFNEGLSYSGKPLGQKT
                     NFSIGAAFNPNVRHLDKAVERMEKKIQCGAHYFLTQPIYSEEKIVEVYEATKHLDTPIY
                     IGIMPLVSARNADFLHHEVPGITLSDEIRARMAACGSDPVQAAKEGIAIAKSLIDAAFD
                     LFNGIYLITPFLRYDMTVELVRYIHEKEAAAKERKVVHG"
     PFAM_domain     6490..7299
                     /aSDomain="S-methyl_trans"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF02574.18"
                     /description="Homocysteine S-methyltransferase"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg5_36_0007"
                     /evalue="1.60E-60"
                     /label="ctg5_36"
                     /locus_tag="ctg5_36"
                     /protein_end="281"
                     /protein_start="11"
                     /score="205.4"
                     /tool="antismash"
                     /translation="LIADGAMGTLLYSHGIDRCFEELNLSNPDEIVHIHEAYIAAGADV
                     IQTNTYGANYVKLARYGLEDEVPAINRAAVRLARQAANGRAYVLGTIGGLRTLNKSVVT
                     LEEVKRTFREQLFVLLAEGVDGVLLETYYDLEELETVLAIARKETDLPIIAHVSLHEVG
                     VLQDGTPLADALIRLEALGADVVGLNCRLGPYHMLRSLEEVPLPKQAFLSAYPNASLPD
                     YRDGRLVYETNAEYFEETAKAFRDQGVRLIGGCCGTTPKHIEAMAKAL"
     PFAM_domain     7423..8175
                     /aSDomain="MTHFR"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF02219.19"
                     /description="Methylenetetrahydrofolate reductase"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg5_36_0008"
                     /evalue="2.30E-26"
                     /label="ctg5_36"
                     /locus_tag="ctg5_36"
                     /protein_end="573"
                     /protein_start="322"
                     /score="92.9"
                     /tool="antismash"
                     /translation="VELDPPKQLGIDKFLAGAKALHDAGIDALTLADNSLATPRISNAA
                     VATIIKEQLGIRPLVHITCRDRNLIGLQSHLMGLHTLGITDVLAITGDPSKIGDFPGAT
                     SVYDLSSFDLIRLIRQFNEGLSYSGKPLGQKTNFSIGAAFNPNVRHLDKAVERMEKKIQ
                     CGAHYFLTQPIYSEEKIVEVYEATKHLDTPIYIGIMPLVSARNADFLHHEVPGITLSDE
                     IRARMAACGSDPVQAAKEGIAIAKSLIDA"
ORIGIN
        1 acgatgaccg ccatcgcgat cattaacaca accgcgatcg tcgcccccat cccccagttt
       61 tgggtgacaa gaaaatgctg ctcaatggcc gtgccgagcg taatgacgcg gttgcccgca
      121 atgaggcgcg taatcataaa cagcgacaac gccgggataa acaccgcctg gcagccggcc
      181 ttcaccccgc caagcgtgag cgggaagacg acgcggcgga acgtcgtcca agccgaggcg
      241 cccaaatcgc gggcggcatc gacaagcgat ggcggcagct cctccagcgc gttgaaaatc
      301 ggcagcacca taaacggaat aaaaatgtac accgacacaa agacaaaact gaaatcggtg
      361 aacaacagct gccgcggccc aacgcccagc gctttcaaca aagcgttggc cagcccgtac
      421 gtgccgaaca gccctaaaaa cgcatacacc ttcagcagca aattcaccca catcggcaaa
      481 ataagcaaca acagccatag ctgcttgtgc cgcgtcttcg tcagccaata ggcggtcgga
      541 tagccgatga gcagcgacac aagcgtgatt aaaaacgcat accaaaacga atacgccatc
      601 attttcaaat aaatgggcgt ccacacggat ttgtagttgg acaacgtcca atggccgtca
      661 agatccaaaa acgattcata caccaaaaag acaatcgggg ccacgacaaa cagcacaagc
      721 caaatgccat aagggattaa ataccagttc cgccacgccc gttccgtcat gcgtcctcat
      781 cctccttttc gagtcgcatg acgtgaatcg cttccggttc aaaacgaagg ccgaccgttt
      841 ccccgacttc ggcctttttc gtcgaatgga caagccattc gttgccgttt tcgtcatagc
      901 cgcaaatttc ataatggaca ccgcggaata agagcgaatc gacgcggatg acgatctgcc
      961 cgtcttccgg cgccgcgagc tccaaatctt ccgggcggat gacgacatcg accggttcgt
     1021 ttggcgcgaa gccgcggtca acacacgcaa actgtttgcc ggcaaattcg acgaggaaat
     1081 catcgatcat gcgccctgac aaaatgttcg attcgccaat gaaatcggcg acgaatcgat
     1141 tgacaggctc gtcgtaaatg tctttcggcg tcccaaactg ctgaattttt cctttattta
     1201 gaacaaaaat gtaatcggac atcgccaacg cttcttcttg atcatgcgtg acaaaaatga
     1261 acgtaatccc taagcggcgc tgcaattcac gaagttcgta ctgcatttcc gtgcgcagct
     1321 tcaaatccaa ggccgatagc ggctcatcca agagcaaaac ttctggctca ttcacaatcg
     1381 cccgcgcaat cgcgacgcgc tggcgctgac cgccggacat ttcttgaatg cggcggcgct
     1441 catagccgtc taagttgaca aaccgaagcg attccctcac tttctcgcga atgtcggttt
     1501 ctttcatctt tttcacgcgc aaaccaaacg caacgttttc aaacacatcg agatgaggga
     1561 acaatgcata gtcttgaaaa acagtgttga cttgccgctt gttcggcggg acgttttgaa
     1621 tcggcttccc gtggaaataa atcgttcctt ccgtcggttc gataaacccg gcaatcagcc
     1681 gcaaaatcgt cgtcttcccg caccctgacg ggccaagcag cgtataaaac ttcccgcgct
     1741 ccatcgcaaa actgacgtca tccaatacga ccgttccgtc gtattccttc gtcactcgct
     1801 cgaagcggat gatctcttcc ccgttcactt ccagccctcc gtcttcttga tgttcactat
     1861 tcctaattag aacataggag agtggaaagt gcaacggaaa aatccttgat cacacgtatg
     1921 aaaactgaat ttttcctgaa gatcccgccg tcatttttct attttgtctt cattgtttgg
     1981 acgtgtaagc gagattatgc gggagccagg gaagcgctct tgatgaacgt gagaagcaat
     2041 gagataagca tgttgacggt cgccttgaat ccactccgcc aaccgatcgc gacttagcct
     2101 atcaagggaa ttgaacggtt catccatcaa atacaatttg accgggcggg ctaaagcaat
     2161 cgcaatatgc agtttttgtt ttgttcctaa tgaatactga tccaccggga gcgggagcat
     2221 ctcctccatt ccaagcagac tgcataattc gttcgctttg cggacgtact gttgatccag
     2281 cttccataaa agccggaaac attcgatatt ttcataaccc gtcaattttg aaaacatgac
     2341 agtctcggat gtcacataag acaaatgagc gcgcatgtct ggaagctgaa tcggattgcc
     2401 tttataaaag gcttgataat gcagctctcc tttatcgagc aatcccgaaa taatatgcaa
     2461 aagagtcgtt ttccccactc cattggggcc ggtgagaagc acggtctccc ctgaaaaaat
     2521 ggaaaatgag aactgctgaa aaatcgtggc tcccccatca tagcgatacg tcaagttttg
     2581 caatgaaaat aacggttcca tctatttctt ccccttttcc tgcttggctc ttcaccaaaa
     2641 gttgtacttg attttttctg aactctattt acgcttgtaa gggaaaatca acaaatccgt
     2701 gattttttca aatctttgtg caggaagctg tattgcttgt caagtacatg ttgtggtgaa
     2761 gagcctcctg ctttttagac ccgtctattt ttatacatga gacaccgttg attccaacca
     2821 tgctgagatg atgagcagcg cgaccgccag cactagtaaa aagaggatat cccgtatata
     2881 gagcgtttct tcttctcctc ttgctctttt tttgacgatt tgaagaaacc gccatgtctc
     2941 gtaccctaat gtacaaaaca agatatggcc gatgatttca ggaatcgcgt gaggaaagac
     3001 accggtcatc aacggctgca tgccatatcc tgtggcgact cctctcacga tcacgcctag
     3061 cattgctgcg ttgtaaccga gataaagggt attggccatt cctagcgtca gccatccgcc
     3121 aaccatcaaa atggctccaa ccatcaagtt gtggcctaaa gtggtccaaa acgccatgga
     3181 agtcggatga atcgtaagct tttgtgaaaa aatcactgct ccaaaagcaa aacatacaat
     3241 gtacacacct aacgacaata acatatacgg caaatgagtg tgaatcgctc gtctgatcac
     3301 cgcaaatgcc tcctcaagtg cgccgagcat attgagaact attccataat acaaggtaca
     3361 gcatcaagac aaacaaaacg ctgtaacatg cccaactcca acctttcaaa agcataaaaa
     3421 aggcagaaag aagtgatgaa aaaacggtta tgtaaatcaa caagcgatga aacgaatgat
     3481 ttccggccgc aatcaccata taccccgcat aatcacgcgg agatgtcaat gccgcctgct
     3541 caccgctggc taaaacaagg cagaatactt cataatcggt gcgcaaaatc cgcttgacaa
     3601 caagcgaata gacgggcatc atcaccacag ctcccattgc tgcccaaagc cctccacgca
     3661 tccccaataa tcctatgtat tcgagaagta gcaatcctac tgccgtcatg catgggtaga
     3721 cgcctaatcg ctcaagcagc gtccatttcg cttcgattaa cggtacaaga ggaggtggag
     3781 aaagaagacg aaacacagtg agacgctcca tctcgctttc aaactgaaaa atgtcgcgaa
     3841 agacgtcggt aatggcccgc aacgtccctg tcatgacgat atacatttca aacataaaca
     3901 aaaacaaaat gatcgacccg ttatgaacaa tcggcaacag cgccaaattc gctcctgcga
     3961 ccaaaaacca ttcccctggc aaaaatagcg accaaggcgg tttcgtcaac tcacgggctt
     4021 ggcgtgttaa cagacaaaga tctttatata aaattgcatt attcgtgctg cgaattttta
     4081 acgactctat gacacgttga tgccatgaat atagcatgta cgctgtcttg tcagaatgag
     4141 acgcacgagt gaaagaaaag caaatcaaag ccaacagagc gaatccagca ccgatgaatg
     4201 ataaagttgc acttgaaaat aaccaccctt ccctccaact tgtcatgcgt tcataaaaca
     4261 gctgttgcca atgagcaaca taaccatcca tatacacaag gtaagagagc gacaacccat
     4321 acattcgaac cgcttggcgg gacaattgca gcaacggcac aatcgccgca agcacgacat
     4381 aaccaatcgc gaatgatgcc attcgaaaga aaaaggcaga aaatgcgcct atcgctctaa
     4441 aagttgagcc acgcactata tgcgatgtca cataaagaag caacaacatc gtatgtccaa
     4501 accatacgaa tgatgcgcct gtgatcccga acatcatcat caacccaatg gaaggaggca
     4561 accaaatcgg caatagccgc agaagagaca cagcatagtg gattttgagc aatcgctgcc
     4621 acacctcgtc atcccgcact ccagacagac gcacataatg ataatggtat tgacgttgca
     4681 atgcctcttt ggactcaagc aaaactccta tgaaaggact gacagacatg aaaaaaagag
     4741 ctcccataac catagaaggg cgaaacagcg tcgaggatcg agcgcaaaag gctacaacca
     4801 cagccgatga aacaagccat ttcgccgctt ccaccaagaa catggtcatc ttcggggaaa
     4861 aaggcgattt tctctgcaac ggcgccaaac tgcttcgttg tcgttgttga tataacagcc
     4921 atacgagttt catttctctt cccccacatt gatttactca ttaggaacgg cagggagttt
     4981 ttcccctgcc gttttgcctt ttaccatgca atcgctgctg cttttcctcg ttccgccact
     5041 atttttttca ccgtcgcgac aaaagctgac cacccaattt ccaaaatgac gtcgactcca
     5101 cctgacaaaa tagcggtgat cccaagaata atagaaatga gagtggagcc ggtcaacaca
     5161 atcgaaacaa ccgtcgtcgc gattgactgt gacacgccga gcgtcccggc aacaagcgcc
     5221 agcaaactca taacctatca tctccttcca gtaaatgata atcgatcaaa acttttttca
     5281 aaaacattct gtgtctatct catccttcgc actaaacgag aataaacccc gccgtaaagc
     5341 agcaccaata caataaatcc tattttgatg ggcatgctgg ccgcttttag gcgaaaagca
     5401 actccaatca acacaacaag cggcaggcta atcagaataa aatacggcca cgaccattgt
     5461 ttcacccact tcactcctgt ctgcgatgcg gtttctagta aattccttgt taatatcatc
     5521 cattttaatt atacaccttg actctaaaaa aaaaaaaaag agaaatcgtt cgataatttt
     5581 atcttttttt acatatttcg acatatttcg tgctattgac atgaaacaga gatgctttta
     5641 agagattagt acaaggtaag ggaggagata caatgcttct tttttattac gtcatcccat
     5701 gtttcctaca tcatcatatg gtataataat cccaaccaac atgaaacgaa tggagaagga
     5761 atccacttga aaagcatcaa acccggccgc gtcccgtcga tgcaagggct gttcggcagc
     5821 atcgccgctg tgttgttcgg catcttttgg atggtgatga ccttctccat caccgcggac
     5881 tcgccgtttc ccgccgcccg cttttttccg tttttcggcc ttgtcgtcat cgccatcggt
     5941 gtatttcaag caatttacca ttacaaaaat gcgacgggaa aacaacgcat gtccttattg
     6001 gacattgtcg tcagcgagga agagcccgac ccactgaacg tccgatttgg aggcaaagag
     6061 aaaacaaaca agtattgccc atactgcgga gaacatgtgc agcgtgattt tcagttttgc
     6121 ccccgatgcg ggaaagcgcc gagcccttga cgcgagccgc tctttttatc tgaatctctt
     6181 taacttttga aatttccttc ttcaccgtat tgaataattt cgaaaaatac attaaattat
     6241 atagtaatca tcaaaacgtc accgcacaat tgcataccgg cattcttatc aagagagggg
     6301 gagggactgg cccggtgaac cctcagcaac ctggcccgcg gccaaggtgc taaatccaga
     6361 caggcggaag cctggaagat aagaagaagc gaatgaaaag tcttcttctt atagaaggct
     6421 tttttctttt actacggaga aacgggggaa tcgaacgtgg gattgctgga tgagttgaaa
     6481 gagcgcattc tcatcgccga cggggcgatg ggaacgcttt tatattcgca cggcattgac
     6541 cgttgttttg aagaattgaa tttatccaat ccagatgaaa tcgtccatat tcatgaagcg
     6601 tatatcgccg cgggcgccga cgtcattcag acgaatacat acggcgccaa ctatgtgaaa
     6661 ctcgcccgct acggccttga agatgaggtg ccggccatca accgcgcggc ggtgcggctc
     6721 gccaggcaag cggcgaacgg gcgggcatac gtgctcggaa cgatcggggg gctgcgcacg
     6781 ttaaacaaaa gcgtcgtcac gcttgaagaa gtgaaacgga cgtttcgcga gcagctgttt
     6841 gtcctgctgg ctgaaggagt cgacggcgtg ctgctcgaga cgtattacga tttggaagag
     6901 ttggagacgg tgcttgccat cgcccgcaaa gagaccgact tgccgattat cgctcacgtc
     6961 tcgctccatg aagtcggcgt cttgcaagat ggcacgccgc tcgcggacgc ccttatccgc
     7021 ctggaggcgc tcggggccga tgtcgtcgga ctgaactgtc gtctcggtcc atatcatatg
     7081 cttcggtcgc tcgaggaagt gccgctgccg aagcaggcgt ttttgtcggc gtatccgaat
     7141 gcgagcctcc cggattaccg cgatggccgg cttgtctatg agacgaacgc tgaatatttc
     7201 gaggaaacag ccaaagcgtt ccgcgaccaa ggggtgcgct tgatcggcgg gtgctgcggc
     7261 acgacgccga aacatattga ggcaatggca aaggcgctcg ccgaccggac gccggtgacg
     7321 gaaaaaacgg tgaagcggcg cacggcatct gtatcggtgc aagccgatcg gcccgcgccg
     7381 actccgcttc ccgagctcgc ccgcacgtac cgctcggtca ttgtggagct agatccgccg
     7441 aagcaactcg gcattgacaa gtttcttgct ggggcgaaag cgctccatga cgccggcatc
     7501 gatgcgctga cgttggccga caactcgctc gccacgccgc gcatcagcaa cgccgctgtc
     7561 gccacgatca tcaaggagca actcggcatc cgcccgcttg tgcatattac atgccgcgat
     7621 cgcaatttga tcggcttaca gtcgcatttg atgggcttgc atacgctcgg catcaccgac
     7681 gtgctcgcca ttaccggcga cccgtcgaaa atcggcgact tcccaggagc aacgtcggtg
     7741 tatgatttat catcgttcga tttgatccgc ttgatccgcc agtttaacga agggctgtcg
     7801 tactcgggca aaccgcttgg gcaaaaaacg aacttctcga tcggcgctgc gttcaacccg
     7861 aacgtccgcc atttggataa agcagttgag cgaatggaga aaaaaattca atgcggcgcc
     7921 cactatttct tgacccagcc gatttactcg gaagagaaaa tcgttgaagt gtacgaagcg
     7981 accaagcatc ttgacacgcc gatttacatc ggcattatgc cgcttgtgag cgcgcgcaac
     8041 gccgactttt tgcatcatga agtgccgggc attacgctct ctgacgagat tcgcgcccgc
     8101 atggccgcct gcggcagcga cccggtgcaa gcagccaagg aaggcatcgc tatcgccaaa
     8161 tcgctcattg acgctgcgtt tgatttgttt aacggcattt atttgatcac gccgttcttg
     8221 cgctatgaca tgacagtcga gctcgtccgc tacattcacg aaaaagaagc ggccgccaaa
     8281 gaaaggaagg ttgttcatgg ctaacgtcac cttagaacag cagctgcaaa gaaaaattct
     8341 tgtcatcgat ggcgccatgg gcacgatgat ccaaagagcc aacctatcgg ccgccgactt
     8401 tggcggcgag gcgtatgaag ggtgcaacga atatttgacc ctcaccgccc cgcatgtcat
     8461 ccgccgcatt catgaagcgt acctagaagc cggtgctgat atcattgaaa cgaacacgtt
     8521 cggagcgaca cgcatcgtgc ttgacgaata tggcctcggt catttggcgc ttgagctgaa
     8581 catcgaagcg gccaaactcg ccaaacaaac ggctgagtcg ttctccaccc cggactggcc
     8641 gcgctttgtc gccggttcga tggggccgac gacgaaaacg ttgtcggtga caggcggcgc
     8701 aacgtttgaa gaactcgtcg ccgcctacga agaacaagcg cgcggactgc tcttaggagg
     8761 cgtcgacctt ctcctactcg agacgtgcca agatacgctg aatgtcaaag ccggttttct
     8821 cggcatttcg aaggcgtttg aagcggtcgg tcgccgcgtg ccgctcatga tttccggcac
     8881 gatcgaaccg atgggcacga cactcgccgg gcaggcgatc gatgcgtttt tcatctcggt
     8941 gcgccatatg aagccgatcg ccgtcggctt aaactgcgcg acaggccccg agtttatgac
     9001 cgaccatttg cgcacgctcg cctcgctcgc tgacacggcg gtcagctgct acccgaacgc
     9061 cggtctgccg gatgaggaag gccgctacca tgaaacgccg gagatgttgg cagagaaaat
     9121 ccgccgcttt gccgaaaaag gatggatcaa catcgtcggc gggtgttgcg gcacgacgcc
     9181 ggatcatatc cgcgccattg ccgaagcggt gcgtgatctc ccgccgcggg cgatcccgtc
     9241 ttcgtttgat gtccacgccg tttccggcat cgaggcgctc atctatgatg aaacgatgcg
     9301 cccgctcttt gtcggcgagc ggacaaacgt gatcggctcg cgcaaattca aacgcctcat
     9361 cgccgaaggg aaatacgaag aagcggcgga aatcgcccgc gcccaagtga aaaacggcgc
     9421 ccatgtcatc gacatttgcc tcgccgaccc agaccgcgac gaactccatg acatggagca
     9481 gttcgtccgc gaagtcgtga aaaaagtgaa agtgccgctt gtcatcgatt caaccgacga
     9541 gcgcgtcatt gaacgcgccc tcacctactc gcaagggaaa gcgatcatca attcgatcaa
     9601 cttggaagac ggcgaggagc ggtttgcgaa agtcgttcct ctcttgcaca aatacggcgc
     9661 cgctgtcgtc gtcggcacga tcgatgaaca agggatggcg gtcaccgccg aacggaagct
     9721 ggaaattgcc ttgcgttcgt atgacttgct cgttaaccgc tacggggtgc cggcgcgcga
     9781 catcattttc gatccgctcg tcttcccggt cggcaccggt gatgagcaat acatcggcgc
     9841 ggcgaatgaa acgatcaaag gcatccgcct cattaaagag cggctgcctc attgcttgac
     9901 gatgctcggc atcagcaacg tctcgttcgg cttgccgccg gccgggcgcg aggtgctcaa
     9961 ctccgtcttt ttgtaccgtt gcacgcaagc tgggctcgat tatgcgatcg tcaacactga
    10021 gaagcttgag cggttcgcct cgattccgga agaggaagtg cggatggccg aagcgctttt
    10081 gtttgacacg agcgatgaaa cattaaacac ctttatcgaa ttttaccgaa gcaaaatcac
    10141 cgccgccaag ccggctgagg agaacttgag ccttgaagag cggctcgccc gctacgtcat
    10201 tgaagggtcg aaagacgggc tcattcccga t
//
