LOCUS       c00026_NZ_CBYM..       15592 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  NZ_CBYM010000026.1 Clostridium saudiense strain JCC, whole genome
            shotgun sequence.
ACCESSION   NZ_CBYM010000026
VERSION     NZ_CBYM010000026
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 6.1.1
            Run date     :: 2024-03-14 15:31:18
            Original ID  :: NZ_CBYM010000026.1
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 31017
            Orig. end    :: 46609
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..15592
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="True"
                     /core_location="[41017:42370](+)"
                     /cutoff="20000"
                     /detection_rule="(TIGR03973 or SCIFF or (cds(PF04055 and
                     (TIGR04085 or SPASM)) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]) and not (TIGR01716
                     or subtilosin or TIGR02111 or TIGR03966 or TIGR04103 or
                     YcaO or TIGR03882)))"
                     /neighbourhood="10000"
                     /product="ranthipeptide"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..11353
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(TIGR03973 or SCIFF or (cds(PF04055 and
                     (TIGR04085 or SPASM)) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]) and not (TIGR01716
                     or subtilosin or TIGR02111 or TIGR03966 or TIGR04103 or
                     YcaO or TIGR03882)))"
                     /neighbourhood="10000"
                     /product="ranthipeptide"
                     /protocluster_number="1"
     cand_cluster    1..15592
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(TIGR03973 or SCIFF or (cds(PF04055 and
                     (TIGR04085 or SPASM)) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]) and not (TIGR01716
                     or subtilosin or TIGR02111 or TIGR03966 or TIGR04103 or
                     YcaO or TIGR03882)))"
                     /kind="single"
                     /product="ranthipeptide"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..15592
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="ranthipeptide"
                     /region_number="1"
                     /rules="(TIGR03973 or SCIFF or (cds(PF04055 and (TIGR04085
                     or SPASM)) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]) and not (TIGR01716
                     or subtilosin or TIGR02111 or TIGR03966 or TIGR04103 or
                     YcaO or TIGR03882)))"
                     /tool="antismash"
     CDS             380..1048
                     /gene_functions="regulatory (smcogs) SMCOG1008:response
                     regulator (Score: 206; E-value: 9.6e-63)"
                     /gene_kind="regulatory"
                     /locus_tag="ctg26_27"
                     /transl_table=11
                     /translation="MSCKILVVEDDNQIQELIVEFLSSQDYDVDVANDGVEGYEKFKEN
                     KYDLVILDVMMPRLDGHALCKMIRNLDKEVSIIFLTALGDEESEIKGFDLKADDYISKP
                     FSFNILIKRVEAVLRRKQKEEKEDTILEFEGLKLDLQTFKSYIDNEEIELTLKEFNILK
                     LMINSYPTVVSREKLIEKIWGYEYFGDTRVIDAHMKNIRKKIKKDYIKTIKGVGYVLEK
                     "
     PFAM_domain     392..721
                     /aSDomain="Response_reg"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00072.26"
                     /description="Response regulator receiver domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg26_27_0001"
                     /evalue="2.60E-30"
                     /label="ctg26_27"
                     /locus_tag="ctg26_27"
                     /protein_end="114"
                     /protein_start="4"
                     /score="105.0"
                     /tool="antismash"
                     /translation="ILVVEDDNQIQELIVEFLSSQDYDVDVANDGVEGYEKFKENKYDL
                     VILDVMMPRLDGHALCKMIRNLDKEVSIIFLTALGDEESEIKGFDLKADDYISKPFSFN
                     ILIKRV"
     PFAM_domain     827..1039
                     /aSDomain="Trans_reg_C"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00486.30"
                     /description="Transcriptional regulatory protein, C
                     terminal"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg26_27_0002"
                     /evalue="6.80E-24"
                     /label="ctg26_27"
                     /locus_tag="ctg26_27"
                     /protein_end="220"
                     /protein_start="149"
                     /score="83.9"
                     /tool="antismash"
                     /translation="EEIELTLKEFNILKLMINSYPTVVSREKLIEKIWGYEYFGDTRVI
                     DAHMKNIRKKIKKDYIKTIKGVGYVL"
     CDS             1032..2558
                     /gene_functions="regulatory (smcogs) SMCOG1003:sensor
                     histidine kinase (Score: 159.6; E-value: 2.6e-48)"
                     /gene_kind="regulatory"
                     /locus_tag="ctg26_28"
                     /transl_table=11
                     /translation="MFLKSKWRNLSIKKKIFLWSSLIIIISFTLLYICMYFFMPRVYEV
                     YKVNNINEKIRELKSQLEKDENIDINELLDEFSYKNNLDILLVSKDENNLINKIIYSSF
                     REGANEPNKIPFLYSHVQYERFKSFQKYSNDINLGGSIATDKFVYGLISKNESLNIDEI
                     VYVKSLNNAYHMIVHFPVSPENEASDSIALFLPFAIFAIVIIAFTISSFYSILISRPLI
                     KINKVAKKMANLDFDNIIEVNGEDEIGELSNSLNLMNKNLKESFEELERMNSKLTEEIE
                     IERKLEKERREFVATISHELKSPITIISGQLEGMLYNIGKYKDRDKYLKESYEVTQKMS
                     ELVQEILHLSERENGEFKYNFSNVNLSNVIKSILRELRYFIDEKKLNLITKIDEDIFII
                     ADEKLIKKVIMNIIKNAIIYSPTNECIKINLSKEELSVENTGVSIPKNQINEIFNAFYR
                     VDKSRNRKTGGTGLGLYIVKTILDKHENIDYTIESGENSVIFKMKFIYKE"
     PFAM_domain     1677..1817
                     /aSDomain="HAMP"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00672.27"
                     /description="HAMP domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg26_28_0003"
                     /evalue="2.50E-08"
                     /label="ctg26_28"
                     /locus_tag="ctg26_28"
                     /protein_end="262"
                     /protein_start="215"
                     /score="34.3"
                     /tool="antismash"
                     /translation="LISRPLIKINKVAKKMANLDFDNIIEVNGEDEIGELSNSLNLMNK
                     NL"
     PFAM_domain     1899..2096
                     /aSDomain="HisKA"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00512.27"
                     /description="His Kinase A (phospho-acceptor) domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg26_28_0004"
                     /evalue="2.00E-10"
                     /label="ctg26_28"
                     /locus_tag="ctg26_28"
                     /protein_end="355"
                     /protein_start="289"
                     /score="40.6"
                     /tool="antismash"
                     /translation="RREFVATISHELKSPITIISGQLEGMLYNIGKYKDRDKYLKESYE
                     VTQKMSELVQEILHLSERENG"
     PFAM_domain     2232..2513
                     /aSDomain="HATPase_c"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF02518.28"
                     /description="Histidine kinase-, DNA gyrase B-, and
                     HSP90-like ATPase"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg26_28_0005"
                     /evalue="1.40E-17"
                     /label="ctg26_28"
                     /locus_tag="ctg26_28"
                     /protein_end="494"
                     /protein_start="400"
                     /score="64.3"
                     /tool="antismash"
                     /translation="DEKLIKKVIMNIIKNAIIYSPTNECIKINLSKEELSVENTGVSIP
                     KNQINEIFNAFYRVDKSRNRKTGGTGLGLYIVKTILDKHENIDYTIESG"
     CDS             complement(2655..3800)
                     /gene_functions="other (smcogs) SMCOG1122:ATP-dependent RNA
                     helicase (Score: 256.3; E-value: 9.3e-78)"
                     /gene_kind="other"
                     /locus_tag="ctg26_29"
                     /transl_table=11
                     /translation="MNMSFNELNLNTNIIEGLKLQGITSPTEVQKLTIPKALENIDIIA
                     ESHTGSGKTLAYLCPIFQKINTDKKEMQAIVLAPTHELVMQIDSQIKLLAKNSNMNITS
                     LTIMGESNIEKQIKKLKEVKPHIIVGSAGRVLDLIKKKKITAHTIKTIVMDEADSLLAK
                     NKSTIIKDIIKATMRDRQLMFFSASINPTSLDIAKSLVKDVEIVKSAGTSVLNPNISHM
                     YIACEFRDRFETLRKFLAAENPERAIVFVNNSTELQNINEKLDYHKVKSTGIYGNASKE
                     ERQRSIEAFRNGKFNVLVSSDVSARGLDIPEVTHIISMDFPANPDEYLHRAGRTARGTL
                     SGNSVCIGTRRDLEAIKAYQKAFKIKFKEMRLYGGNLIPVK"
     PFAM_domain     complement(2787..3110)
                     /aSDomain="Helicase_C"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00271.33"
                     /description="Helicase conserved C-terminal domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg26_29_0007"
                     /evalue="1.80E-26"
                     /label="ctg26_29"
                     /locus_tag="ctg26_29"
                     /protein_end="338"
                     /protein_start="230"
                     /score="92.8"
                     /tool="antismash"
                     /translation="RFETLRKFLAAENPERAIVFVNNSTELQNINEKLDYHKVKSTGIY
                     GNASKEERQRSIEAFRNGKFNVLVSSDVSARGLDIPEVTHIISMDFPANPDEYLHRAGR
                     TARG"
     PFAM_domain     complement(3231..3722)
                     /aSDomain="DEAD"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00270.31"
                     /description="DEAD/DEAH box helicase"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg26_29_0006"
                     /evalue="1.30E-34"
                     /label="ctg26_29"
                     /locus_tag="ctg26_29"
                     /protein_end="190"
                     /protein_start="26"
                     /score="119.6"
                     /tool="antismash"
                     /translation="TEVQKLTIPKALENIDIIAESHTGSGKTLAYLCPIFQKINTDKKE
                     MQAIVLAPTHELVMQIDSQIKLLAKNSNMNITSLTIMGESNIEKQIKKLKEVKPHIIVG
                     SAGRVLDLIKKKKITAHTIKTIVMDEADSLLAKNKSTIIKDIIKATMRDRQLMFFSASI
                     N"
     CDS             4162..6309
                     /locus_tag="ctg26_30"
                     /transl_table=11
                     /translation="MKDAFKIYKNDMKNIFKNYGALIVVIALCILPSLYAWFNIKASWD
                     PYAESATSGIKIGVVNKDLGATLNGKEVNLGNDVVDELKNNKQMGWQFVSEEEATKNVE
                     EGKYYAMITIPEDFSKSLTSIITQDIEKGNIIYTVNEKINAIAPKLTDKGASAIQEKVS
                     KAVVETASDAIFGVGKDLGTELENQLPRLNNIYNQLLEVQSQFSNINDVVNLAGDGADK
                     LKTLISDIQNDIPLITETLENSQKLGTNLEEFLSTSKSNLNNIAPVIKNDIKILNEIAN
                     EISTNTSALVDAINSGSAYAPEIVDSILEKLNSINKSAESLIGILETMNKFNPGKFDDI
                     INTLTNVQGAINKSITALNTVKDSIANGGTPDLSLLNNVISFTNDVSNITNDLYNNFDS
                     NITNKINTIFDDAYTVADNVVSVLKEAQDKLPQVTDIMNTVYEGADKGIEGIDFVKSKL
                     PEAENLLNDLISKIGSVNDSTDIKELINYLKSDVDTRSDFLSNPVNIIENKLFPMGNYG
                     TGMTPFYTVLSLWVGLLLLASMLTVEAEGEYSAASQYFGKMLLFMTIAIIQAIIVSLGD
                     LYVLKIYCVNPALFVLSSVFTSIIFTFILYSLCSVLGNVGKVLGIVLLVLQIGGSGGTF
                     PIQLTPKFFQAINPFLPFTYAISLARESIGGVVQSVLVKDIVVLLIFGAIFILISLFLK
                     KPINKLLHGFAESIEKSGIGE"
     aSDomain        4192..4686
                     /aSDomain="TIGR03061"
                     /aSTool="tigrfam"
                     /description="pip_yhgE_Nterm: YhgE/Pip N-terminal domain"
                     /detection="hmmscan"
                     /domain_id="TIGRFam_ctg26_30_0002"
                     /evalue="2.80E-47"
                     /identifier="TIGR03061"
                     /label="ctg26_30"
                     /locus_tag="ctg26_30"
                     /protein_end="175"
                     /protein_start="10"
                     /score="158.3"
                     /tool="antismash"
                     /translation="DMKNIFKNYGALIVVIALCILPSLYAWFNIKASWDPYAESATSGI
                     KIGVVNKDLGATLNGKEVNLGNDVVDELKNNKQMGWQFVSEEEATKNVEEGKYYAMITI
                     PEDFSKSLTSIITQDIEKGNIIYTVNEKINAIAPKLTDKGASAIQEKVSKAVVETASDA
                     IF"
     PFAM_domain     4228..6234
                     /aSDomain="ABC2_membrane_3"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF12698.9"
                     /description="ABC-2 family transporter protein"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg26_30_0008"
                     /evalue="1.90E-10"
                     /label="ctg26_30"
                     /locus_tag="ctg26_30"
                     /protein_end="691"
                     /protein_start="22"
                     /score="40.5"
                     /tool="antismash"
                     /translation="IVVIALCILPSLYAWFNIKASWDPYAESATSGIKIGVVNKDLGAT
                     LNGKEVNLGNDVVDELKNNKQMGWQFVSEEEATKNVEEGKYYAMITIPEDFSKSLTSII
                     TQDIEKGNIIYTVNEKINAIAPKLTDKGASAIQEKVSKAVVETASDAIFGVGKDLGTEL
                     ENQLPRLNNIYNQLLEVQSQFSNINDVVNLAGDGADKLKTLISDIQNDIPLITETLENS
                     QKLGTNLEEFLSTSKSNLNNIAPVIKNDIKILNEIANEISTNTSALVDAINSGSAYAPE
                     IVDSILEKLNSINKSAESLIGILETMNKFNPGKFDDIINTLTNVQGAINKSITALNTVK
                     DSIANGGTPDLSLLNNVISFTNDVSNITNDLYNNFDSNITNKINTIFDDAYTVADNVVS
                     VLKEAQDKLPQVTDIMNTVYEGADKGIEGIDFVKSKLPEAENLLNDLISKIGSVNDSTD
                     IKELINYLKSDVDTRSDFLSNPVNIIENKLFPMGNYGTGMTPFYTVLSLWVGLLLLASM
                     LTVEAEGEYSAASQYFGKMLLFMTIAIIQAIIVSLGDLYVLKIYCVNPALFVLSSVFTS
                     IIFTFILYSLCSVLGNVGKVLGIVLLVLQIGGSGGTFPIQLTPKFFQAINPFLPFTYAI
                     SLARESIGGVVQSVLVKDIVVLLIFGAIFILISL"
     aSDomain        5650..6246
                     /aSDomain="TIGR03062"
                     /aSTool="tigrfam"
                     /description="pip_yhgE_Cterm: YhgE/Pip C-terminal domain"
                     /detection="hmmscan"
                     /domain_id="TIGRFam_ctg26_30_0001"
                     /evalue="8.50E-50"
                     /identifier="TIGR03062"
                     /label="ctg26_30"
                     /locus_tag="ctg26_30"
                     /protein_end="695"
                     /protein_start="496"
                     /score="167.2"
                     /tool="antismash"
                     /translation="DFLSNPVNIIENKLFPMGNYGTGMTPFYTVLSLWVGLLLLASMLT
                     VEAEGEYSAASQYFGKMLLFMTIAIIQAIIVSLGDLYVLKIYCVNPALFVLSSVFTSII
                     FTFILYSLCSVLGNVGKVLGIVLLVLQIGGSGGTFPIQLTPKFFQAINPFLPFTYAISL
                     ARESIGGVVQSVLVKDIVVLLIFGAIFILISLFLKK"
     CDS             6479..7570
                     /locus_tag="ctg26_31"
                     /transl_table=11
                     /translation="MRRKEIDWIRNICILMLFIYHTSAIFTDFGDFYIKTEKSNIFSNI
                     FILLTFSWYMPLLFFLAGASTYFALKRRSEFEYIKERTKKLLLPFIFGIIVIVPPQTYL
                     ARLWRGESNINYFSHMKMFFTNVSDFMGFDGGFTPAHLWFILFLFVISLIGVSIIKCFK
                     LIGGKKVMNKIKNVILSKYGLFIVIALTFIAEMVPGVGGKGLILNLLMFLFGYITYSDI
                     DYINAIFKYRRTFAISNGIIIILGLGYFLSLRNMEIGILKNIAENGIKCSMIITAIITI
                     VGYGIKYMNKENKLLRYLNKASFPVYIMHQTILLTLAFFILPLMFPQWFSIIIINLLSV
                     LITFGLYEIIKRTRYIGILLGMK"
     PFAM_domain     6488..7507
                     /aSDomain="Acyl_transf_3"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF01757.24"
                     /description="Acyltransferase family"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg26_31_0009"
                     /evalue="3.20E-27"
                     /label="ctg26_31"
                     /locus_tag="ctg26_31"
                     /protein_end="343"
                     /protein_start="3"
                     /score="95.6"
                     /tool="antismash"
                     /translation="KEIDWIRNICILMLFIYHTSAIFTDFGDFYIKTEKSNIFSNIFIL
                     LTFSWYMPLLFFLAGASTYFALKRRSEFEYIKERTKKLLLPFIFGIIVIVPPQTYLARL
                     WRGESNINYFSHMKMFFTNVSDFMGFDGGFTPAHLWFILFLFVISLIGVSIIKCFKLIG
                     GKKVMNKIKNVILSKYGLFIVIALTFIAEMVPGVGGKGLILNLLMFLFGYITYSDIDYI
                     NAIFKYRRTFAISNGIIIILGLGYFLSLRNMEIGILKNIAENGIKCSMIITAIITIVGY
                     GIKYMNKENKLLRYLNKASFPVYIMHQTILLTLAFFILPLMFPQWFSIIIINLLSVLIT
                     "
     CDS             7762..8661
                     /locus_tag="ctg26_32"
                     /transl_table=11
                     /translation="MKKEVFLKDIKNGTEIKISLMVMRVIFRDTSKVVCILADKTGEIK
                     ATIPNKTGDIIEGKVIEIEGKRDVNLEVKKYALVKEYNAIDYLPTVKRDIEDIMTEIEL
                     YTDEYIISREGKALNDYFFKDESFLEKFKRAIGGVSMHHNYIGGLAEHTLGVMYLTIML
                     CERYNCRNKEIAILAAKLHDIGKIYELYYDGPFKYTLRGEMEGHIVIGIQMIEKAFNDN
                     PGFYSEDFITRIKGCIVQHHGKLEYGSPREMRMEESFILNSADSIDATMNKIEQIKEKT
                     EAGSWSEYDRRIETKLYL"
     aSDomain        8203..8412
                     /aSDomain="TIGR00277"
                     /aSTool="tigrfam"
                     /description="HDIG: HDIG domain"
                     /detection="hmmscan"
                     /domain_id="TIGRFam_ctg26_32_0003"
                     /evalue="4.60E-08"
                     /identifier="TIGR00277"
                     /label="ctg26_32"
                     /locus_tag="ctg26_32"
                     /protein_end="217"
                     /protein_start="147"
                     /score="30.8"
                     /tool="antismash"
                     /translation="GLAEHTLGVMYLTIMLCERYNCRNKEIAILAAKLHDIGKIYELYY
                     DGPFKYTLRGEMEGHIVIGIQMIEK"
     PFAM_domain     8209..8568
                     /aSDomain="HD"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF01966.24"
                     /description="HD domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg26_32_0010"
                     /evalue="3.60E-11"
                     /label="ctg26_32"
                     /locus_tag="ctg26_32"
                     /protein_end="269"
                     /protein_start="149"
                     /score="43.4"
                     /tool="antismash"
                     /translation="AEHTLGVMYLTIMLCERYNCRNKEIAILAAKLHDIGKIYELYYDG
                     PFKYTLRGEMEGHIVIGIQMIEKAFNDNPGFYSEDFITRIKGCIVQHHGKLEYGSPREM
                     RMEESFILNSADSIDA"
     CDS             8698..8874
                     /locus_tag="ctg26_33"
                     /transl_table=11
                     /translation="MNGFKDKLNEEDIFVESESSNTSIVNVESIVKSNNKNNFNDLKDN
                     IDIEREKFGQNNK"
     CDS             8994..9245
                     /locus_tag="ctg26_34"
                     /transl_table=11
                     /translation="MSIRNNKKIIFGALSAVVASVAAGVLVKNNIDKKASNQGEKKKEK
                     KSKNVYYTVYLNDIYNPYDDKTMSEDDMIEEIKKETSL"
     CDS             10001..11353
                     /gene_functions="biosynthetic (rule-based-clusters)
                     ranthipeptide: Ranthipeptide_rSAM_RRE"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     ranthipeptide: PF04055"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     ranthipeptide: SPASM"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     ranthipeptide: TIGR04085"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_12"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg26_35"
                     /sec_met_domain="PF04055 (E-value: 1.4e-18, bitscore: 59.2,
                     seeds: 518, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_12 (E-value: 5.2e-14, bitscore: 44.1,
                     seeds: 84, tool: rule-based-clusters)"
                     /sec_met_domain="TIGR04085 (E-value: 3.1e-22, bitscore:
                     70.2, seeds: 281, tool: rule-based-clusters)"
                     /sec_met_domain="SPASM (E-value: 4.5e-09, bitscore: 28.1,
                     seeds: 166, tool: rule-based-clusters)"
                     /sec_met_domain="Ranthipeptide_rSAM_RRE (E-value: 2.7e-27,
                     bitscore: 86.4, seeds: 20, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MALIHKFKQGDNFFVLDVNTGAVHIVDELVYDLVDDNKLRDKEEL
                     IKEFGAKYGEETISEAYEELLELIDEDILYSRDQYEDIAHSSMDDRDYIKAVCLNIIHG
                     CNLRCKYCFADEGEYNGHKGVMSVETAKKAIDYVVKRSGPRRNIEIDLFGGEPTMIMDK
                     VKEIIAYARENEKAWNKNIRFTMTTNATLLTEEMMDFMDKEMGNIILSLDGRKEVNDNV
                     RIKVDGSGSYDDILPNIKRMIEKRDKSKHYYVRGTFTGANTDFYEDVKAMVNEGFREIS
                     IEPVVLEKGHFLELKEEHLPEIFENYDKLYNEMARRKKEGDEFNFYHFNIDLNGGPCVY
                     KRISGCGAGFEYVAITPQGEVYPCHQFVGKEEFKLGSIYDDTYDAELGKKFKKAHIYNK
                     PKCRECWARFYCSGGCQSNNFAFNGDMNIPYEIGCKMQKKRIECAIALKAE"
     aSDomain        10010..11347
                     /aSDomain="TIGR03974"
                     /aSTool="tigrfam"
                     /description="rSAM_six_Cys: SCIFF radical SAM maturase"
                     /detection="hmmscan"
                     /domain_id="TIGRFam_ctg26_35_0004"
                     /evalue="1.10E-189"
                     /identifier="TIGR03974"
                     /label="ctg26_35"
                     /locus_tag="ctg26_35"
                     /protein_end="449"
                     /protein_start="3"
                     /score="628.9"
                     /tool="antismash"
                     /translation="IHKFKQGDNFFVLDVNTGAVHIVDELVYDLVDDNKLRDKEELIKE
                     FGAKYGEETISEAYEELLELIDEDILYSRDQYEDIAHSSMDDRDYIKAVCLNIIHGCNL
                     RCKYCFADEGEYNGHKGVMSVETAKKAIDYVVKRSGPRRNIEIDLFGGEPTMIMDKVKE
                     IIAYARENEKAWNKNIRFTMTTNATLLTEEMMDFMDKEMGNIILSLDGRKEVNDNVRIK
                     VDGSGSYDDILPNIKRMIEKRDKSKHYYVRGTFTGANTDFYEDVKAMVNEGFREISIEP
                     VVLEKGHFLELKEEHLPEIFENYDKLYNEMARRKKEGDEFNFYHFNIDLNGGPCVYKRI
                     SGCGAGFEYVAITPQGEVYPCHQFVGKEEFKLGSIYDDTYDAELGKKFKKAHIYNKPKC
                     RECWARFYCSGGCQSNNFAFNGDMNIPYEIGCKMQKKRIECAIALKA"
     PFAM_domain     10298..10738
                     /aSDomain="Radical_SAM"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF04055.23"
                     /description="Radical SAM superfamily"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg26_35_0011"
                     /evalue="7.00E-16"
                     /label="ctg26_35"
                     /locus_tag="ctg26_35"
                     /protein_end="246"
                     /protein_start="99"
                     /score="59.1"
                     /tool="antismash"
                     /translation="NIIHGCNLRCKYCFADEGEYNGHKGVMSVETAKKAIDYVVKRSGP
                     RRNIEIDLFGGEPTMIMDKVKEIIAYARENEKAWNKNIRFTMTTNATLLTEEMMDFMDK
                     EMGNIILSLDGRKEVNDNVRIKVDGSGSYDDILPNIKRMIEKR"
     PFAM_domain     11036..11218
                     /aSDomain="SPASM"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF13186.8"
                     /description="Iron-sulfur cluster-binding domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg26_35_0012"
                     /evalue="2.60E-06"
                     /label="ctg26_35"
                     /locus_tag="ctg26_35"
                     /protein_end="406"
                     /protein_start="345"
                     /score="27.9"
                     /tool="antismash"
                     /translation="CGAGFEYVAITPQGEVYPCHQFVGKEEFKLGSIYDDTYDAELGKK
                     FKKAHIYNKPKCRECW"
     aSDomain        11036..11287
                     /aSDomain="TIGR04085"
                     /aSTool="tigrfam"
                     /description="rSAM_more_4Fe4S: radical SAM additional
                     4Fe4S-binding SPASM domain"
                     /detection="hmmscan"
                     /domain_id="TIGRFam_ctg26_35_0005"
                     /evalue="3.60E-20"
                     /identifier="TIGR04085"
                     /label="ctg26_35"
                     /locus_tag="ctg26_35"
                     /protein_end="429"
                     /protein_start="345"
                     /score="70.2"
                     /tool="antismash"
                     /translation="CGAGFEYVAITPQGEVYPCHQFVGKEEFKLGSIYDDTYDAELGKK
                     FKKAHIYNKPKCRECWARFYCSGGCQSNNFAFNGDMNIP"
     CDS             11496..12707
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_M16"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_M16_C"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg26_36"
                     /sec_met_domain="Peptidase_M16 (E-value: 2.5e-28, bitscore:
                     90.3, seeds: 24, tool: rule-based-clusters)"
                     /sec_met_domain="Peptidase_M16_C (E-value: 7.4e-28,
                     bitscore: 89.1, seeds: 139, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MEEYIFDNGLKLIYKKSNSELSSICISLDAGASRDGEKLGVAHVT
                     EHMVYKGTETRSEKQINTELSNIFGFQNAMTNYPYVVFYGTLLSEDLKKGLDLFSDILL
                     QPVFTEEGFKEEMEVIKQELKEWDEDLEQYTEDKLYYNCMDNRRLKYPIIGTEESLNNM
                     TIDDTIDFFNDYYCANNATITIISDLEFEDIRDMVEDCFIDWRSEKLPEDEEVINYPKT
                     GVFINKKEDINSAKVQIIFPINELNQWEIKALRVFNQYFGEGVNSILFDTLRTKHGLVY
                     DVLTRVANEEYIKVYKITYSTAHENVDKSIEIVKELIKDVDSYREKLKKEDIEKLIKSF
                     RLKRLFANEQSVRLAMGISTYDTMFGDGMLYIDETEDLDKMPIDYIIDTANKVLNNMTV
                     QVIK"
     PFAM_domain     11538..11963
                     /aSDomain="Peptidase_M16"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00675.22"
                     /description="Insulinase (Peptidase family M16)"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg26_36_0013"
                     /evalue="3.90E-26"
                     /label="ctg26_36"
                     /locus_tag="ctg26_36"
                     /protein_end="156"
                     /protein_start="14"
                     /score="91.9"
                     /tool="antismash"
                     /translation="KKSNSELSSICISLDAGASRDGEKLGVAHVTEHMVYKGTETRSEK
                     QINTELSNIFGFQNAMTNYPYVVFYGTLLSEDLKKGLDLFSDILLQPVFTEEGFKEEME
                     VIKQELKEWDEDLEQYTEDKLYYNCMDNRRLKYPIIGT"
     PFAM_domain     11982..12506
                     /aSDomain="Peptidase_M16_C"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF05193.23"
                     /description="Peptidase M16 inactive domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg26_36_0014"
                     /evalue="4.90E-25"
                     /label="ctg26_36"
                     /locus_tag="ctg26_36"
                     /protein_end="337"
                     /protein_start="162"
                     /score="88.7"
                     /tool="antismash"
                     /translation="MTIDDTIDFFNDYYCANNATITIISDLEFEDIRDMVEDCFIDWRS
                     EKLPEDEEVINYPKTGVFINKKEDINSAKVQIIFPINELNQWEIKALRVFNQYFGEGVN
                     SILFDTLRTKHGLVYDVLTRVANEEYIKVYKITYSTAHENVDKSIEIVKELIKDVDSYR
                     EKLKKEDIEKLI"
     CDS             12720..14126
                     /locus_tag="ctg26_37"
                     /transl_table=11
                     /translation="MSKKVPLLEEVLKYKKENNLILSMPGNKSGIGFLRDDIGKEFALN
                     MGFLDITEVDPLDNLHAPEGIIKEAQELLAETYGVKKAYFVVNGSTAGNLASIFDAFNE
                     GDEVLVERNCHKSVYNGLILRKLKVKYIEPVIHEDKGLFLPPTEKEIYKALDRCNNARG
                     IILTYPNYFGIGYDIFDTLKDLKERGLTIIIDGAHGAHYGISERLPKSIVSYADYIVLS
                     AHKTLPSLTQGSYLLVNNDKNVGFYLKAFMTTSPSYLIMSSLDYSRYYLDNYGEKDYDK
                     LIGLANKWSIKINTLNKVSILKEEDLPQGYNLDLSRYILTLPKGYSGHKLLDYLRKMKI
                     QCEMSFACGVVLILSPFNLEKDFEKIYNSIEKLDLSLIVDNQYQNYYSIIPEKVLEPYE
                     VFDKDFEYVDIKKSIGKISKEALIPYPPGIPLICGGEVISKEAVEIMLGYIRNNKTVIG
                     IEEELVKVIK"
     PFAM_domain     12735..13622
                     /aSDomain="OKR_DC_1"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF01276.22"
                     /description="Orn/Lys/Arg decarboxylase, major domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg26_37_0015"
                     /evalue="2.50E-45"
                     /label="ctg26_37"
                     /locus_tag="ctg26_37"
                     /protein_end="301"
                     /protein_start="5"
                     /score="155.1"
                     /tool="antismash"
                     /translation="PLLEEVLKYKKENNLILSMPGNKSGIGFLRDDIGKEFALNMGFLD
                     ITEVDPLDNLHAPEGIIKEAQELLAETYGVKKAYFVVNGSTAGNLASIFDAFNEGDEVL
                     VERNCHKSVYNGLILRKLKVKYIEPVIHEDKGLFLPPTEKEIYKALDRCNNARGIILTY
                     PNYFGIGYDIFDTLKDLKERGLTIIIDGAHGAHYGISERLPKSIVSYADYIVLSAHKTL
                     PSLTQGSYLLVNNDKNVGFYLKAFMTTSPSYLIMSSLDYSRYYLDNYGEKDYDKLIGLA
                     NKWSIKINTLNKVSI"
     PFAM_domain     13815..14075
                     /aSDomain="OKR_DC_1_C"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF03711.17"
                     /description="Orn/Lys/Arg decarboxylase, C-terminal domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg26_37_0016"
                     /evalue="9.10E-10"
                     /label="ctg26_37"
                     /locus_tag="ctg26_37"
                     /protein_end="452"
                     /protein_start="365"
                     /score="39.1"
                     /tool="antismash"
                     /translation="IYNSIEKLDLSLIVDNQYQNYYSIIPEKVLEPYEVFDKDFEYVDI
                     KKSIGKISKEALIPYPPGIPLICGGEVISKEAVEIMLGYIRN"
     CDS             14211..14333
                     /locus_tag="ctg26_38"
                     /transl_table=11
                     /translation="MDYKVADVTKEEVEAIKRAENLIKSETGKEFVMIAWEKIK"
     CDS             14508..15590
                     /locus_tag="ctg26_39"
                     /transl_table=11
                     /translation="VVTINKLKILSLLVLSGILITPSHIAKAEGIYNVSESDLIKLLEK
                     YKDEEIVLEDGLVLTVGQAINLPIDEGWTIYNENVAEIVDGELVGKSVGSTFVSQQTED
                     TVYILEVCITEEGISTASYARSNVKNVDRDYYKVFIDPGHGGVDNGAVQNGVLEDEINL
                     QISKKIEAKLKAKGVEVKMSRYDDTYLSLTDRTYMANKEGSDVFVSIHQNSATNSSAKG
                     IETYYYSTRQDSKELATDIQNDLIQATNATDRGVKTANYAVIKTASMSSSLVECGFISN
                     PTEAQNLSSSSYQDKVAEGIVNGIMDYLNNNVILNNSGTQKPGDSTTTETVQTGTVKVS
                     NSLNVRSGAGTNYSVLGSLSN"
     PFAM_domain     14919..15422
                     /aSDomain="Amidase_3"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF01520.20"
                     /description="N-acetylmuramoyl-L-alanine amidase"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg26_39_0017"
                     /evalue="1.10E-57"
                     /label="ctg26_39"
                     /locus_tag="ctg26_39"
                     /protein_end="305"
                     /protein_start="137"
                     /score="194.9"
                     /tool="antismash"
                     /translation="VFIDPGHGGVDNGAVQNGVLEDEINLQISKKIEAKLKAKGVEVKM
                     SRYDDTYLSLTDRTYMANKEGSDVFVSIHQNSATNSSAKGIETYYYSTRQDSKELATDI
                     QNDLIQATNATDRGVKTANYAVIKTASMSSSLVECGFISNPTEAQNLSSSSYQDKVAEG
                     IVNGI"
ORIGIN
        1 agaaggtatt aaaaatgagt atgagttact tttagttaaa ttttctgacg tagacaaggc
       61 aaaggtagtt tcttcattat caaaatcagt aaaatcaaat tctattgtaa taatgcttaa
      121 aaaacataaa gaagataata atatgcttaa taatataaat ttatatttaa atatgaaaaa
      181 tgttttttta ggttttcttt tgtgaaacat aaatagatat ctccttaatt gctattatat
      241 atatttatat taaatctcga accttaaaat aacctgaaat atatggatta ataattgaaa
      301 tttgaatgaa tttaagaaga ttttaagggt agtatgctaa aattataaag aataagtgaa
      361 aaagattatg gaggaaaata tgagttgtaa aatattagtt gtagaagacg ataatcaaat
      421 acaggaatta atagtagagt ttttatcttc acaagattat gatgttgatg tagcaaatga
      481 tggtgttgaa ggttatgaaa agttcaaaga aaataaatat gatttagtaa ttttagatgt
      541 gatgatgcca agacttgatg ggcatgcatt atgtaaaatg ataagaaatt tagataaaga
      601 agtatcaata atttttttaa cagcattagg ggatgaagaa agtgagataa aaggatttga
      661 tttaaaagct gatgattata ttagcaagcc tttttcattt aatatattga ttaaaagagt
      721 agaagctgtt ttacgaagaa aacaaaaaga agaaaaagag gatacaatat tagagttcga
      781 gggattaaaa ttagatttac aaacttttaa atcttatatt gataatgaag aaattgaact
      841 tactttaaag gagtttaata tattaaagct aatgataaat agttatccga cggtagtttc
      901 aagagaaaaa ttaattgaaa aaatatgggg ttatgaatat tttggtgata ctagagttat
      961 tgatgctcac atgaaaaata ttagaaagaa aataaagaag gattatataa aaactatcaa
     1021 gggtgtagga tatgttcttg aaaagtaaat ggagaaattt aagcataaag aaaaagatat
     1081 ttttatggag tagtcttatt ataataattt catttacttt actatacata tgtatgtatt
     1141 tttttatgcc gagagtttat gaggtttata aagtaaataa tataaatgaa aaaataagag
     1201 aactaaaatc tcaattagaa aaagatgaaa atatagatat taatgagctt cttgatgagt
     1261 tttcttataa aaataatttg gatattttgc ttgtaagtaa agatgagaat aatttaataa
     1321 ataaaattat ttattcatca tttagagaag gagcaaatga acccaataaa attccatttt
     1381 tatatagtca tgtacaatat gaacgattta aaagttttca gaaatatagt aatgatatta
     1441 atttgggtgg tagtattgca acagataaat ttgtgtatgg attaattagt aagaatgaaa
     1501 gtttgaatat tgatgagatt gtttatgtta aaagtttaaa taatgcatat catatgattg
     1561 tacatttccc agttagtcca gaaaatgaag caagtgatag tattgcgcta tttttaccat
     1621 ttgctatttt tgcaatagtg atcatagcat ttactatttc aagtttttat tcaatattaa
     1681 taagtagacc tttgataaag attaataaag ttgctaaaaa aatggctaat ttagattttg
     1741 ataatattat agaagttaat ggtgaggatg aaataggaga gctttcaaat agtttaaatt
     1801 taatgaataa gaatttaaaa gaatcctttg aagagttaga aagaatgaac tctaagctta
     1861 ctgaggaaat tgagatagaa agaaaactag aaaaagaaag aagagaattc gttgctacta
     1921 tttctcatga gttaaaatcg cctataacta taataagtgg gcaattagaa ggaatgcttt
     1981 ataatattgg aaaatataaa gatagagata aatatttaaa agaatcatat gaagttacac
     2041 aaaaaatgag tgaattagtt caagaaattt tacatttaag tgaaagggaa aatggtgaat
     2101 ttaaatataa cttttcaaat gttaatttaa gtaatgttat caaaagtata ttaagagagt
     2161 taagatattt tattgatgaa aagaaattaa acttgattac taaaatagat gaagacattt
     2221 ttataattgc tgatgaaaag cttattaaaa aggtaataat gaatattatt aaaaatgcaa
     2281 taatatactc cccaaccaat gaatgtataa aaataaattt atctaaagag gaactaagtg
     2341 ttgaaaatac aggtgtttca ataccaaaga atcaaattaa tgaaattttt aatgcatttt
     2401 atagagttga taaatctaga aatagaaaaa ctggtggaac tggattaggg ctttatatag
     2461 taaaaactat tttagataaa catgaaaata ttgattatac tatagaaagt ggagaaaatt
     2521 cagtaatttt taaaatgaaa tttatttaca aggaataaaa attaaaaaaa tagatattat
     2581 attttgttta atataatatc tattttttta tgattaaaga aagtaatatt aattacagta
     2641 aaaataaatt tgtattattt tacaggaatt aagttaccac catatagtct catttcttta
     2701 aattttattt taaaggcttt ttggtaagct ttgatagctt ctaagtcacg tctagtacca
     2761 atacatactg aatttcctga aagtgtacca cgtgcagttc ttccagctct atgtaaatat
     2821 tcatctggat ttgcagggaa atccatgctt ataatatgag taacctctgg aatatcaaga
     2881 ccacgagctg atacatcaga tgaaactaaa acattgaatt taccatttct aaaagcttcg
     2941 atagatcttt gtctttcttc tttagaagca tttccataaa ttccagtaga tttaacctta
     3001 tgataatcta atttttcatt tatattttga agttcagtac tattatttac aaatactata
     3061 gctctttctg ggttttcagc agctaagaat tttcttagtg tttcaaatct atccctaaat
     3121 tcacaagcta tatacatatg tgaaatatta ggatttaata cagaagttcc tgctgattta
     3181 acaatctcaa catccttaac tagtgattta gctatatcta aagatgtagg atttatgctt
     3241 gcagagaaga acataagttg tctatctctc atagtagctt taataatatc tttaattatt
     3301 gtagatttat ttttggctaa aagactgtca gcttcatcca taactatagt tttaatagta
     3361 tgtgcagtta tttttttctt tttaattaag tctaagactc ttcctgcaga acctactatt
     3421 atatgtggct ttacttcttt aagttttttt atttgttttt caatatttga ttcacccatt
     3481 attgttaatg aagttatatt catattggag ttttttgcaa gtaatttaat ttgtgaatct
     3541 atttgcataa ctaattcatg agtaggagct aaaactatag cttgcatttc ttttttatca
     3601 gtatttattt tttgaaaaat agggcataaa taagctaatg tcttaccact tccagtatga
     3661 gattctgcta ttatatctat attttctaaa gcttttggaa tagtaagctt ttgaacctct
     3721 gtaggtgaag ttatcccttg aagctttaat ccttctatta tgtttgtatt taaattaagt
     3781 tcattaaatg acatattcat tttattctcc tcggttatta ataattatct attttagtat
     3841 acactaaaaa taatttaagt atagaaattt atttttttta atataaaatg atttttaaat
     3901 aattagtaca taataataat atattaaaat taacaaggta aaaaatggag gaaaaatgaa
     3961 taaaatgtta agataatgtt taatttttgt taaaaaaatt aaaaagattt ttgggagtat
     4021 acgtatactt acaactatat agccattttt aattaaaaaa cagtattaat atatttagaa
     4081 aactaaaact tgaattttag taccaaagtg ataatataat aataaagtaa gtgaaagtca
     4141 aatacaaagg agaaaaaaga gatgaaggat gcatttaaaa tttataagaa tgatatgaaa
     4201 aatatcttta aaaattatgg tgcactaatt gttgttatag cattatgtat actaccatct
     4261 ttatatgctt ggtttaatat caaagcatct tgggatccat atgctgaatc ggctactagt
     4321 ggaattaaga taggagttgt aaacaaagat ttaggggcaa ctttaaatgg taaagaagtt
     4381 aatttgggaa atgatgttgt agatgaattg aaaaataata agcagatggg atggcagttt
     4441 gtaagtgaag aagaagcaac taaaaatgtt gaagaaggca aatattatgc catgattaca
     4501 attccagagg atttttcaaa gagtcttaca tctataatta cacaagatat tgaaaaagga
     4561 aatataatat atacagtaaa tgagaagata aatgcaattg cgcctaagct tacagataag
     4621 ggagcaagtg ctatacaaga aaaggtaagt aaagcagttg tagaaactgc aagtgatgca
     4681 atctttggag taggaaaaga tttaggaact gaattagaaa atcagcttcc tagattaaat
     4741 aatatttata atcaattatt agaggttcaa agtcagtttt ctaatataaa tgatgttgta
     4801 aatttagctg gagatggagc tgataaatta aaaacattaa tttcagatat tcaaaatgat
     4861 attcctttaa taactgaaac attagaaaat tcacaaaagt taggtacaaa tttagaagaa
     4921 tttttaagta cttcaaaaag taatttaaat aatattgcac ctgtaataaa gaatgatata
     4981 aaaatattaa atgaaattgc aaatgaaatt tctacaaata caagtgcatt agttgatgca
     5041 attaattcag gatcagcata tgcaccagaa atagttgata gtattttaga aaagttaaat
     5101 agcataaata agagtgctga atcattaatt ggaatattag aaactatgaa taaatttaat
     5161 ccaggaaaat ttgatgatat tattaatacc ttaacaaacg ttcaaggagc aataaataaa
     5221 tcaattactg cgttaaatac agttaaagat agtatagcta atggtggaac accagattta
     5281 agtttattaa ataacgttat atcatttact aatgatgtaa gtaatattac aaatgattta
     5341 tataataact ttgattcaaa tattactaat aaaattaata ctatttttga tgatgcatat
     5401 actgtagcag ataatgtagt atcagtatta aaagaagcac aagataaatt accacaagta
     5461 acagatatta tgaatactgt ttatgaaggt gctgataagg gtatcgaggg gattgatttt
     5521 gtaaaatcaa aacttccaga agctgaaaat ttgcttaatg atttaataag taaaatagga
     5581 agtgttaatg atagtacaga tattaaagag cttataaatt atttaaagag tgatgtagat
     5641 acaagaagtg actttttatc aaatcctgtt aatattatag aaaataaatt attcccaatg
     5701 ggtaactatg gaacaggaat gacacctttc tatacagtat tatcattatg ggtaggatta
     5761 ttattattgg catctatgct aactgttgaa gcagagggtg aatactctgc agcatcacaa
     5821 tattttggaa aaatgttgtt atttatgaca atagcaataa ttcaagcgat aatagtatca
     5881 ttaggggatt tatatgtttt aaaaatatat tgtgtaaatc cggctttatt tgtattaagt
     5941 agtgtattta ctagcattat atttacattt atattatatt cactatgctc agtgcttgga
     6001 aatgtaggta aagtattagg aattgtacta ttagttttac aaataggtgg ttcaggagga
     6061 acattcccaa ttcaattaac accaaagttc ttccaagcaa ttaatccatt tttacctttc
     6121 acttatgcga tttcacttgc aagagaatct ataggtggag tagttcaaag tgtattggtt
     6181 aaggatatag ttgttctgtt aatatttgga gcaatcttta tattaatttc attattctta
     6241 aagaaaccaa ttaataaatt attacatgga tttgctgaaa gtattgaaaa gagcggtatt
     6301 ggagaataag ttaataagta ttttatataa taatgggcga tgtatttgat tttaatacat
     6361 tgcctattat tatataagta caaagtaagc aaaaaaaatt agtagtaaat agttaaaaag
     6421 tatgataaaa gtagtatata ttacgtttac aaaatattca taaaattaag gagaatttat
     6481 gagaagaaaa gaaatcgatt ggataagaaa catatgcata ttaatgttgt ttatttatca
     6541 tacatcagca atatttacag actttggaga tttttatatt aaaacagaaa aaagtaatat
     6601 tttttctaac atatttatac tattaacttt ttcttggtat atgcctttat tattcttttt
     6661 agctggggca tcaacatatt ttgctcttaa aagaagaagt gaatttgaat acataaaaga
     6721 aagaactaaa aagctattac ttccatttat atttggaata atagtaatag tacctcctca
     6781 aacttattta gctagacttt ggagaggtga aagtaatata aactatttta gtcatatgaa
     6841 aatgttcttt acgaatgtaa gtgatttcat ggggtttgat ggaggtttca cacctgcaca
     6901 cctttggttc atattatttt tatttgtgat ttcattaatt ggtgttagta ttattaaatg
     6961 ctttaagctt attggtggaa agaaagtaat gaacaaaatt aaaaatgtta ttttaagtaa
     7021 atacggttta tttatagtta ttgcattaac ttttattgca gaaatggtac caggggttgg
     7081 tggaaaggga ttaattttaa atcttttaat gttcttattt ggatatatta cttatagtga
     7141 tattgattat ataaatgcta tttttaaata tagaagaaca tttgcaatat caaatggaat
     7201 tattattata ttaggacttg gatatttttt aagcttaaga aacatggaaa taggtatctt
     7261 aaagaatata gctgaaaatg gaattaaatg ttctatgata attacggcta tcataactat
     7321 agttggttat ggaataaaat atatgaataa agaaaataaa ttattaaggt atttaaataa
     7381 agcttcattt ccagtatata ttatgcatca aactatttta ttaacattag cattttttat
     7441 attaccatta atgtttccac aatggttttc tataattata ataaacttgt tatcggtttt
     7501 aataacattt ggattatatg aaataattaa aagaacaaga tatataggaa tattacttgg
     7561 aatgaaataa ctactttaga tgaatataaa aataaaatta cccatataga ttaggcaaat
     7621 aggagtgtct aatctatatg ggtttctatt atataaaaaa ataactttat gaatattaga
     7681 tgataagtta ggaaaatatt ttagtatttt ttaggttaaa ctaagttata ggatgagtat
     7741 agtctttgga ggaattaaca aatgaagaag gaagtatttt tgaaagatat caaaaatggt
     7801 acagaaataa aaatatcatt gatggtaatg agggtaatat ttagggatac aagtaaagta
     7861 gtatgtattt tagcagataa aacaggtgaa ataaaagcaa ctataccaaa taaaacagga
     7921 gatattattg aaggaaaggt tatagaaata gagggtaaga gagatgttaa cttagaagtt
     7981 aaaaaatatg cattggtaaa agagtataat gctatagatt acttgcctac agtaaaaagg
     8041 gatatagagg atataatgac tgaaattgaa ttgtatacag atgaatatat aatttcaaga
     8101 gaaggaaagg ctttaaatga ttatttcttt aaagatgaaa gtttcttaga aaaatttaaa
     8161 agagccattg gaggagtttc aatgcatcat aactatatag ggggattagc agagcataca
     8221 ttaggagtaa tgtatttaac aattatgctt tgtgaaaggt ataattgtag aaataaagaa
     8281 attgcaattt tggcagcaaa gttacatgat atagggaaaa tatatgaatt atattatgat
     8341 ggaccattta agtatacatt aagaggtgaa atggaaggtc atatagtaat aggaatacag
     8401 atgatagaaa aagcatttaa tgataatcct ggtttttata gtgaggattt tattacaaga
     8461 ataaaaggat gtatagtaca gcatcatgga aaacttgagt atggatcacc tagggaaatg
     8521 agaatggagg aatcttttat tcttaattct gccgattcta ttgatgcaac tatgaataag
     8581 atagaacaaa taaaggaaaa aacagaagct ggaagttggt cagaatatga tagaaggatt
     8641 gaaacaaagt tatatttata gtgatataga attattataa ggaaaggaga tggtaacatg
     8701 aatggattta aggataaatt aaatgaagag gatatatttg tagaaagtga aagtagcaat
     8761 acttccattg taaatgttga aagtatagtt aagtctaata ataaaaataa ttttaatgat
     8821 ttaaaggata atatagatat agaaagagag aagtttgggc aaaataataa gtagatatta
     8881 gataaaaaat gtatttttgc agttttaatt atgtaacgaa aaattaacta atttataaat
     8941 tgacttggat aattaatatg gatataatct tttataatag tgaggtggag agtatgagta
     9001 taagaaacaa taagaagatt atttttggag cactatcagc agttgtggca tcagttgcag
     9061 ctggggtatt agttaaaaat aatattgata aaaaagctag taatcaaggc gaaaagaaga
     9121 aagaaaagaa aagtaaaaat gtatattaca cagtatattt aaatgatatt tataatccat
     9181 atgatgataa aactatgtca gaagatgata tgatagaaga aataaaaaaa gaaacatcat
     9241 tatagaaaat aaaagagtgt ttactattaa tttacttttg tttattataa tgtaagtaaa
     9301 ttaatagtaa atgctttttt attatttaaa tttaataaaa aatattattt ggtatttttt
     9361 taaagttgct atattataat aagaaagtga gatagttgca tttttgaatg ggaaaataat
     9421 agctttatta ccatagaaaa ttgtgctata attacaacgg tatatttttt tattggagga
     9481 ttcgacatga aacacataaa aacaatcaat aagacaaaca tcaaaaacag tctttgcaaa
     9541 ccaggttgca aagaatgtgc aaactcatgc caatcagctt gcaaaacttc ttgcacagtt
     9601 gctaacttag agtgtgaaaa ctaattaagg acaagcagta actatttact agttactgct
     9661 taactttata aatgaggttc taaatctgtg atttagttaa ccgaatttac tcattcgacc
     9721 gtagggagca ggagtttcct ttgaattgga atctgtgatt tagttaaccg aatttactca
     9781 ttcgactgga gggagaagga gtttctttta aaaggaatct gtgatttagt ttagtagaaa
     9841 ttacacaaga tgtacttatc tagttaagag gataaggagt tttattataa ttatgtggaa
     9901 gttgagttta tctaattgat attaggatta aatgaattat taggttgtaa tcgcgagaaa
     9961 gagcgtatta ataaaaaaga atactaggag gaattgtgaa atggctttaa tacacaaatt
    10021 taaacaagga gataacttct ttgttttaga cgttaataca ggggctgtac atattgtaga
    10081 cgaattagtt tacgatttag tagatgataa taaactaaga gataaagaag aacttataaa
    10141 agaatttgga gctaaatatg gtgaagaaac tatatcagaa gcttatgaag aattattaga
    10201 gcttatagat gaagatatat tatattcaag agatcaatat gaagatatag cacattcatc
    10261 aatggatgat agagattata ttaaagcagt atgtttaaat ataattcatg gatgtaattt
    10321 aagatgtaaa tattgttttg ctgatgaagg tgagtataat ggacataaag gtgtaatgtc
    10381 tgttgaaaca gcaaaaaagg cgatagatta cgtagtaaag agaagtggtc caagaagaaa
    10441 cattgaaatt gatttatttg gtggagaacc aacaatgatc atggacaaag ttaaagaaat
    10501 aatagcttat gctagagaaa atgaaaaggc ttggaacaag aatatcagat ttactatgac
    10561 tacaaatgca actcttttaa ctgaagaaat gatggatttc atggataaag aaatgggtaa
    10621 cataatcctt tcattagatg gtagaaaaga agttaatgat aatgtaagaa ttaaagttga
    10681 tggaagtggt tcttatgatg atatacttcc aaatattaag agaatgattg aaaagagaga
    10741 taaatctaag cattactatg taagaggaac atttacagga gctaatactg acttctatga
    10801 agatgttaag gctatggtaa atgaaggatt tagagaaatt tcaattgaac cagtagtttt
    10861 agaaaaagga catttcttag agcttaaaga agagcactta ccagaaatat ttgaaaacta
    10921 tgataaacta tataatgaaa tggctagaag aaagaaagaa ggagatgaat tcaacttcta
    10981 tcactttaac attgatttaa atggtggacc atgtgtttat aaaagaattt caggatgcgg
    11041 tgcaggattt gaatatgttg caataactcc acaaggagaa gtttatccat gtcaccaatt
    11101 tgtaggtaag gaagaattta agctaggaag catttatgat gatacttatg atgctgaatt
    11161 aggtaagaaa tttaagaagg ctcacatcta taacaagcca aaatgtagag aatgttgggc
    11221 aagattctac tgtagtggtg gatgtcaatc aaataacttt gcatttaatg gagatatgaa
    11281 tattccttat gaaataggat gtaaaatgca aaagaagaga attgaatgtg caatagcact
    11341 taaagctgaa taagataacg aataaggaca ggcatttgct tgtccttatt gtttattatt
    11401 aaaatatatt ggtttataat attaataaat attattgaat aaagccgtag agtttatagc
    11461 ttgtgtttaa gcaaaaaata agaggtgata cataaatgga agagtatatt tttgataacg
    11521 gattaaagtt gatttataaa aaaagtaata gtgagttaag ttctatatgc atatcattag
    11581 atgcaggagc ttcaagagat ggtgaaaagc ttggagtagc acatgtaact gagcatatgg
    11641 tttataaagg aacagaaaca agaagtgaaa aacaaataaa cacagaatta agcaatatat
    11701 ttggattcca aaatgctatg actaattatc cttatgttgt gttttatgga acattattaa
    11761 gtgaagattt aaaaaaagga ttagatttat tttcagatat tcttttacaa ccagtattta
    11821 ctgaagaagg ttttaaagaa gaaatggaag taataaagca agaacttaag gaatgggatg
    11881 aagatttaga gcaatacaca gaggataagc tttattataa ttgtatggat aatagaagac
    11941 ttaagtatcc tattatagga actgaagaat cattaaataa catgacaata gatgatacaa
    12001 tagacttctt taatgattat tattgtgcaa ataatgcaac aattactatt atttcagatt
    12061 tagaatttga agatattaga gatatggtag aagattgctt tattgactgg agaagtgaaa
    12121 agcttcctga agatgaagaa gtaattaatt atcctaagac tggagtattt ataaataaaa
    12181 aggaagatat aaatagtgca aaggtacaaa ttatatttcc aattaatgaa ttaaatcaat
    12241 gggaaataaa agcattaaga gtttttaatc aatactttgg agaaggtgta aactcaattt
    12301 tgtttgatac attaagaaca aagcatggat tagtttatga tgtattaact agagtagcaa
    12361 acgaagaata tataaaagtt tataaaataa cttatagtac tgcacatgaa aatgtggata
    12421 aatcaataga aattgtgaaa gagttaataa aagatgttga ttcttataga gaaaaattaa
    12481 aaaaagaaga tattgagaaa ttaataaaga gctttaggct aaaaagatta tttgcaaatg
    12541 agcaaagtgt gagattagct atgggaatat caacatatga tactatgttt ggagatggta
    12601 tgttatatat tgatgaaact gaagatttag ataagatgcc tatagattat attattgata
    12661 cagctaataa agtattgaat aatatgacag ttcaagtaat taagtaagaa gaggaaaata
    12721 tgagtaaaaa agtaccttta ttagaagaag tattaaaata taaaaaagag aataatctta
    12781 ttctttcaat gccaggaaat aaaagtggta ttggattttt aagagatgat ataggaaaag
    12841 aatttgcatt aaatatggga ttcttggata ttacagaagt tgatccatta gataatcttc
    12901 atgcaccaga agggataata aaagaagctc aagaattatt agcagaaaca tatggggtta
    12961 aaaaagcata ttttgttgtt aatggcagca cagcaggaaa tttagcttct atttttgatg
    13021 cctttaatga aggggatgaa gttttagtag aaagaaattg tcataagtca gtttataacg
    13081 gacttatttt aagaaaatta aaggtaaagt atatagaacc tgtaattcat gaagataaag
    13141 ggttattttt accaccaaca gaaaaggaaa tatataaagc attagataga tgtaataatg
    13201 caagaggaat aatattaact tatcctaatt actttgggat aggatatgat atttttgaca
    13261 cattaaaaga tttgaaggaa agaggattga ctataattat agatggagca catggagctc
    13321 attatggaat aagtgaaagg ttgcctaaat ctatagtttc atatgcggat tatattgttt
    13381 taagtgcaca taagactttg cctagcttaa ctcaaggttc atatctttta gtaaataatg
    13441 ataagaatgt tggtttttat ttaaaagctt ttatgacaac atcaccatca tatttaataa
    13501 tgtcatcatt agattattca agatattatt tagataatta tggagaaaaa gattatgata
    13561 aattaatagg tttggcaaat aagtggagta ttaaaattaa tacgttaaat aaagtaagta
    13621 ttttaaaaga agaagactta ccacagggtt ataatttaga tttaagtagg tatatattaa
    13681 ctttgccaaa aggatatagt ggacataaat tgttagacta tttacgaaag atgaaaatac
    13741 aatgtgaaat gagttttgca tgtggagtag tattaatttt atcacctttt aatttagaaa
    13801 aagattttga aaagatttat aattcaattg aaaaattaga tttatcatta atagtagata
    13861 atcaatatca aaattattat agtataattc ctgaaaaagt attagagcca tatgaagtat
    13921 ttgataaaga ttttgagtat gttgatatta agaagagtat agggaaaatt tcaaaagaag
    13981 cattaattcc ttatccacca ggaattccat taatttgtgg cggtgaagta atatcaaaag
    14041 aagctgttga aatcatgctt ggatatatca gaaataataa aactgtgatt gggatagagg
    14101 aagagttagt aaaagtaata aagtagtaaa aaataaattc ttaaatttaa atgaatacct
    14161 atagttaaaa tttcaaaaac tataatatat catttaaagg agatgagttt atggattata
    14221 aagttgcaga tgtaactaaa gaagaagttg aagcaattaa aagagctgaa aatttaatta
    14281 agtctgaaac aggtaaagag tttgtgatga tagcatggga aaaaattaaa taatatttta
    14341 tataaaatta caatatagat aaaaatatat tgtaattttt tattatttat aaattaaaaa
    14401 taagagaatt tcaattaaaa attggataat agcaaaatat taataaaagt tggtttattt
    14461 tgccgtaaaa atatgtataa taaatgtata tgtaaataga aagcaaggtg gttaccatta
    14521 ataaattaaa gatattaagc ttattagtac tttcgggaat attaattact ccatctcata
    14581 tagcaaaagc agaaggaatt tataatgtat ctgaaagtga tctaattaaa ttattagaaa
    14641 aatataaaga tgaagaaatt gtattagaag atggattagt tttaactgta ggacaagcta
    14701 ttaatttacc aatagatgaa ggctggacta tatataatga aaatgtggct gaaatagtag
    14761 atggtgagct tgttggaaaa tcagtaggta gtacttttgt atctcaacaa acagaggata
    14821 ccgtatacat actagaagta tgtataactg aagagggtat aagtacagct agttatgcta
    14881 gaagtaatgt taaaaatgta gatagagatt actacaaggt atttattgat ccaggacatg
    14941 gtggagttga taatggagct gtacaaaatg gagttcttga agatgaaatt aacttgcaaa
    15001 tatctaaaaa aatagaagct aagttaaaag ctaaaggtgt agaagttaag atgagtaggt
    15061 atgatgatac atatttatct ttaactgata gaacttatat ggctaacaaa gaaggttcag
    15121 atgtatttgt ttctatacat caaaattctg ctacaaattc tagcgcaaaa ggaatcgaaa
    15181 cttattatta ttcaacgaga caagatagta aggagttagc tacagatata caaaatgatt
    15241 taatccaagc tacaaatgca actgatagag gggtaaaaac agcaaattat gcggttatta
    15301 aaactgcatc aatgtcttca agtcttgtag aatgtggatt tatctctaat cctactgaag
    15361 cgcaaaattt aagttctagt agttatcaag ataaggttgc tgaaggaatt gttaatggaa
    15421 taatggatta tttaaataat aatgttatat taaataattc aggaacacaa aagccaggag
    15481 attctacaac gacagaaact gtacaaacag gtactgtaaa agtaagtaat tcattaaatg
    15541 taagaagtgg agctggaact aattattctg ttttaggatc attaagtaat gg
//
