LOCUS       c00051_NZ_FNPG..       12435 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  NZ_FNPG01000038.1 Lachnobacterium bovis DSM 14045, whole genome
            shotgun sequence.
ACCESSION   NZ_FNPG01000038
VERSION     NZ_FNPG01000038
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 6.1.1
            Run date     :: 2024-03-14 13:32:03
            Original ID  :: NZ_FNPG01000038.1
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 12435
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..12435
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="True"
                     /core_location="[3970:4715]"
                     /cutoff="20000"
                     /detection_rule="(TIGR04223 or AgrB)"
                     /neighbourhood="10000"
                     /product="cyclic-lactone-autoinducer"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      3971..4715
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(TIGR04223 or AgrB)"
                     /neighbourhood="10000"
                     /product="cyclic-lactone-autoinducer"
                     /protocluster_number="1"
     cand_cluster    1..12435
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(TIGR04223 or AgrB)"
                     /kind="single"
                     /product="cyclic-lactone-autoinducer"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..12435
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="cyclic-lactone-autoinducer"
                     /region_number="1"
                     /rules="(TIGR04223 or AgrB)"
                     /tool="antismash"
     CDS             3..251
                     /locus_tag="ctg51_1"
                     /transl_table=11
                     /translation="KTIKGYKKSEEEKKTYMYSTNYYSVYSASKEQKVVKLSKKKIYNE
                     EYKYRDLKDQVILTSDKNVVDDYNKMSEKFVQKYFES"
     CDS             467..886
                     /locus_tag="ctg51_2"
                     /transl_table=11
                     /translation="MREKLETEDTIKEFDRQVFESIVDYVIVGGYNKEGNADPSKITFV
                     YRTGFKDCKDANHFKPERLNASKKKNGSGSHNKEVCQSDDTSSNSSLSHSGLQSLIPDD
                     SNTLQSNTSPDACGSRHMSTKGEFVEILEFTGVRE"
     CDS             1194..1550
                     /locus_tag="ctg51_3"
                     /transl_table=11
                     /translation="MTDRVFETFGQRLRKCRNNKNMTKEQVAEALGVTQDYYGKIENDK
                     LMLSYDILEQLYRMEWDIGYIITGCELGQEESLWLMKDIMDVEFDKNQQSLRFWLYVME
                     SQINKGVLQTIIFL"
     PFAM_domain     1230..1361
                     /aSDomain="HTH_3"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF01381.24"
                     /description="Helix-turn-helix"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg51_3_0001"
                     /evalue="7.80E-10"
                     /label="ctg51_3"
                     /locus_tag="ctg51_3"
                     /protein_end="56"
                     /protein_start="12"
                     /score="38.8"
                     /tool="antismash"
                     /translation="LRKCRNNKNMTKEQVAEALGVTQDYYGKIENDKLMLSYDILEQL"
     CDS             1728..2492
                     /locus_tag="ctg51_4"
                     /transl_table=11
                     /translation="MEVGNLLRIAICDDDKKDIEYMEEIISESGMDKNEVYFHEYGSGE
                     DLLMHIKELPSCDLLILDMQMGEMDGHETAAAFRKVFPKTTLVFWSGVCRPTDESFKAT
                     PFRYLFKNYSKEMMIQEMQAVVREVKSKQTVPYIIGNYYYNTVRFEPDDILYIENYRFG
                     SIIHPYQEKVDYDFEKKGDIKTKKKLNELYEELQPFGFEYAHNSYIVNMNYVTKMSSEG
                     DLKLKDDTLLRISRSKQKSFREAFSELMGYKY"
     PFAM_domain     1752..2090
                     /aSDomain="Response_reg"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00072.26"
                     /description="Response regulator receiver domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg51_4_0002"
                     /evalue="2.80E-11"
                     /label="ctg51_4"
                     /locus_tag="ctg51_4"
                     /protein_end="121"
                     /protein_start="8"
                     /score="43.7"
                     /tool="antismash"
                     /translation="IAICDDDKKDIEYMEEIISESGMDKNEVYFHEYGSGEDLLMHIKE
                     LPSCDLLILDMQMGEMDGHETAAAFRKVFPKTTLVFWSGVCRPTDESFKATPFRYLFKN
                     YSKEMMIQE"
     PFAM_domain     2166..2465
                     /aSDomain="LytTR"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF04397.17"
                     /description="LytTr DNA-binding domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg51_4_0003"
                     /evalue="1.50E-11"
                     /label="ctg51_4"
                     /locus_tag="ctg51_4"
                     /protein_end="246"
                     /protein_start="146"
                     /score="44.5"
                     /tool="antismash"
                     /translation="VRFEPDDILYIENYRFGSIIHPYQEKVDYDFEKKGDIKTKKKLNE
                     LYEELQPFGFEYAHNSYIVNMNYVTKMSSEGDLKLKDDTLLRISRSKQKSFREAF"
     CDS             2507..3811
                     /locus_tag="ctg51_5"
                     /transl_table=11
                     /translation="MELIDCAILLASCAVEIYFLHSFFGMLFEKRVWFADNRLRIWLFN
                     IFAVFLLYLCNMIGNGDTNLIVVPIISWIYTYILFHGKFGSRMLYFIMAFSIIWGSEWI
                     YAIILGLGNDAYKTMSEMPFTVLSLKLLTYIIFIIVEQLIGTKKKKMDNRIFLKYLCLP
                     IASFGMMTGVFYSGIDFSTGVGIRMLMTVCYILMLFGNILIFYAFNQYSDEMNSNMENQ
                     ALIMKQQADLEYFMQMAESQERHNEFIHNISHYLRTINQFAQENDCQSIVKIVGELDSH
                     MEASEMKLYSNYHVLNAILSEKGRLAEKQNIIFDAYVEPGIVLDMVEDVDLIAMLGNLL
                     DNALRAAKTYKEEAFVNVRMYMQDIRGFCVLKIVNSYSGDIIMKEDTFISTKKEKGIHG
                     LGIKSVNRMAEKYGGYLTCKAKDDVFEAVLLISTN"
     PFAM_domain     3488..3799
                     /aSDomain="HATPase_c_5"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF14501.8"
                     /description="GHKL domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg51_5_0004"
                     /evalue="1.10E-21"
                     /label="ctg51_5"
                     /locus_tag="ctg51_5"
                     /protein_end="431"
                     /protein_start="327"
                     /score="76.7"
                     /tool="antismash"
                     /translation="EDVDLIAMLGNLLDNALRAAKTYKEEAFVNVRMYMQDIRGFCVLK
                     IVNSYSGDIIMKEDTFISTKKEKGIHGLGIKSVNRMAEKYGGYLTCKAKDDVFEAVLLI
                     "
     CDS             3971..4126
                     /gene_functions="biosynthetic (rule-based-clusters)
                     cyclic-lactone-autoinducer: TIGR04223"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg51_6"
                     /sec_met_domain="TIGR04223 (E-value: 1.1e-15, bitscore:
                     47.6, seeds: 127, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSKFKKENVMKVINCLALVLVAASANSACFFYFHQPEFPKAADKF
                     RQIGND"
     aSDomain        3992..4093
                     /aSDomain="TIGR04223"
                     /aSTool="tigrfam"
                     /description="quorum_AgrD: cyclic lactone autoinducer
                     peptide"
                     /detection="hmmscan"
                     /domain_id="TIGRFam_ctg51_6_0001"
                     /evalue="3.00E-13"
                     /identifier="TIGR04223"
                     /label="ctg51_6"
                     /locus_tag="ctg51_6"
                     /protein_end="41"
                     /protein_start="7"
                     /score="47.6"
                     /tool="antismash"
                     /translation="NVMKVINCLALVLVAASANSACFFYFHQPEFPKA"
     CDS             4119..4715
                     /gene_functions="biosynthetic (rule-based-clusters)
                     cyclic-lactone-autoinducer: AgrB"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg51_7"
                     /sec_met_domain="AgrB (E-value: 2.9e-38, bitscore: 121.2,
                     seeds: 181, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIEKAADWYARKQIRAGIIKEEDRDVYKYGYILAMEMGINILISG
                     MMAFIFNMLECLIVFSCVFIPLRTFCGGWHASKSWICSLISNVTIAGIMIVEKYQIWTF
                     GIWVAVIIELVCSIAVWNMAPIEHKNKPLSNQEKKAYRKICKVMYVVQLGLMFLFYCIG
                     RTDILQTGVMAHIIVVLSLLMGAVDIKKERIIFEK"
     PFAM_domain     4134..4658
                     /aSDomain="AgrB"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF04647.17"
                     /description="Accessory gene regulator B"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg51_7_0005"
                     /evalue="7.00E-35"
                     /label="ctg51_7"
                     /locus_tag="ctg51_7"
                     /protein_end="180"
                     /protein_start="5"
                     /score="120.1"
                     /tool="antismash"
                     /translation="ADWYARKQIRAGIIKEEDRDVYKYGYILAMEMGINILISGMMAFI
                     FNMLECLIVFSCVFIPLRTFCGGWHASKSWICSLISNVTIAGIMIVEKYQIWTFGIWVA
                     VIIELVCSIAVWNMAPIEHKNKPLSNQEKKAYRKICKVMYVVQLGLMFLFYCIGRTDIL
                     QTGVMAHIIVVL"
     CDS             5092..5457
                     /gene_functions="other (smcogs) SMCOG1026:transposase
                     (Score: 115.2; E-value: 5.5e-35)"
                     /gene_kind="other"
                     /locus_tag="ctg51_8"
                     /transl_table=11
                     /translation="LSDVKNQNTKKGKANKVFPNLVNREFNVTEPNKVWCTDFTYMPRP
                     NGSIRYNCSIIDLFDRSAVATLNGSNITAELAIATLQKALDVHKPGKGIILHSDQGSQY
                     TSKEFNEFCEKIMCNKV"
     PFAM_domain     5176..5436
                     /aSDomain="rve"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00665.28"
                     /description="Integrase core domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg51_8_0006"
                     /evalue="3.30E-18"
                     /label="ctg51_8"
                     /locus_tag="ctg51_8"
                     /protein_end="115"
                     /protein_start="28"
                     /score="65.9"
                     /tool="antismash"
                     /translation="TEPNKVWCTDFTYMPRPNGSIRYNCSIIDLFDRSAVATLNGSNIT
                     AELAIATLQKALDVHKPGKGIILHSDQGSQYTSKEFNEFCEK"
     PFAM_domain     5454..5636
                     /aSDomain="rve_3"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF13683.8"
                     /description="Integrase core domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg51_9_0007"
                     /evalue="1.70E-11"
                     /label="ctg51_9"
                     /locus_tag="ctg51_9"
                     /protein_end="61"
                     /protein_start="0"
                     /score="43.8"
                     /tool="antismash"
                     /translation="MSRAGCPYDNAPMERFYNIFKSEFYYLYSFTSDAEIDQKTLEFIY
                     GKYNHKRPHTHNGGCT"
     CDS             5454..5663
                     /locus_tag="ctg51_9"
                     /transl_table=11
                     /translation="MSRAGCPYDNAPMERFYNIFKSEFYYLYSFTSDAEIDQKTLEFIY
                     GKYNHKRPHTHNGGCTSHATRYAE"
     CDS             5728..7149
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF04055"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_12"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg51_10"
                     /sec_met_domain="PF04055 (E-value: 2.6e-16, bitscore: 50.6,
                     seeds: 518, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_12 (E-value: 1e-10, bitscore: 32.2,
                     seeds: 84, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKLNGKEFTTKSGAEYVYLSDMNIVLSKNAIEAYPQRRELLSQIP
                     GYKKTNEYYDCYREYTPEEIKLEIMKNGLCELAIEVTSACNFRCEYCVYSGKYENQRLH
                     DYQNMDVTTVFKAIDKYYELIEEGIEYNSDRTPVISYYGGEPLVKFDLIKKCTEYAKEK
                     FDNNILFTITTNGSLMNDDVIDFFVNEKFNVVVSIDGYKENHNRNRKDVKGNPTFDSVI
                     ENARKLFLKQGTPVFTSVVFDYDTDFVLMEKFFRDNDFLVCLSINSVNPYSTTYFDKYT
                     VDSYDRFKAKLDILMKEFELSVVDNEANPLAFMSRTFGDICTSSFMRQCDISKKNNKII
                     KHTGACVPGNKIFVDVNGDFYICEKVGRSIVIGNVEEGINYEKCAQVVNRYNNLVVHKC
                     RNCVIRNNCKRCYVSIDMDENKINIPAESCKKQIEDYFADLSFAYSIFESNPKWIGRYF
                     SEYYDAINDMMVMLR"
     PFAM_domain     5962..6432
                     /aSDomain="Radical_SAM"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF04055.23"
                     /description="Radical SAM superfamily"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg51_10_0008"
                     /evalue="2.80E-13"
                     /label="ctg51_10"
                     /locus_tag="ctg51_10"
                     /protein_end="235"
                     /protein_start="78"
                     /score="50.7"
                     /tool="antismash"
                     /translation="IEVTSACNFRCEYCVYSGKYENQRLHDYQNMDVTTVFKAIDKYYE
                     LIEEGIEYNSDRTPVISYYGGEPLVKFDLIKKCTEYAKEKFDNNILFTITTNGSLMNDD
                     VIDFFVNEKFNVVVSIDGYKENHNRNRKDVKGNPTFDSVIENARKLFLKQGTP"
     CDS             7146..8360
                     /locus_tag="ctg51_11"
                     /transl_table=11
                     /translation="MKKYFKLFEECYIVSGKDKYTLYNVLTGNIYEIDEKRGKFCLLSE
                     NNMDIENACNNSGLLLSEAKIFIKEMESATLGMMSDFPIAMDKLNILPKWTEKMFFKQS
                     HGINKATIGMDYDCSNSCNFCGNDAVTNRYKCWSCNSTSRSPIADDVAFRIIDIISERD
                     CKELYLKEGDLLSDWGKTLRIVDYALNRGIEKVLLNIIHPIDDMTIINDMRVRNISLVL
                     QRYIEKKKQIELIMSESRKYEGLDVTYILLTELDNKETIMQVAQNISQMYSYKLLIDFM
                     IPNKLENVSKEYFDIERTIGKIDLVSYSIRQFHNECFYKNCYFDKEGNVYPCAGLKNRK
                     YGDIDSMPETFRSENLGNYWNMSLSKKQECKECSMRFACNNCESLNYTLTGSHDRNVLC
                     VKTII"
     CDS             8371..9267
                     /gene_functions="transport (smcogs) SMCOG1000:ABC
                     transporter ATP-binding protein (Score: 181.1; E-value:
                     4.6e-55)"
                     /gene_kind="transport"
                     /locus_tag="ctg51_12"
                     /transl_table=11
                     /translation="MKNVIEFKGVTKKYGEKTVIDDVTFTVEKGDIFGYLGPNGSGKTT
                     SIRMMLDLLHVSSGEILLFGKPIGKNDIRKKIGICLDDEGFYPELTAYQNLEYFDRIYN
                     DASGRKKRIDEFIDRVGLSNSNSELVGNFSKGMKRRLGIARALLNNPELLILDEPTNGL
                     DPDGQKYVSELLMYLSGKTTVFLSSHNLNIIEDVCNKVAIIKNRLLFCDKMDSIACNHT
                     ILYNLTFSNKKDSYEFINQLDTVDHSVIDDRLIVRVNEAEQQLAEKLIKEHGLVIESKK
                     NSDRKLENLYFSVLKED"
     PFAM_domain     8431..8853
                     /aSDomain="ABC_tran"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00005.29"
                     /description="ABC transporter"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg51_12_0009"
                     /evalue="1.00E-29"
                     /label="ctg51_12"
                     /locus_tag="ctg51_12"
                     /protein_end="161"
                     /protein_start="20"
                     /score="103.9"
                     /tool="antismash"
                     /translation="DDVTFTVEKGDIFGYLGPNGSGKTTSIRMMLDLLHVSSGEILLFG
                     KPIGKNDIRKKIGICLDDEGFYPELTAYQNLEYFDRIYNDASGRKKRIDEFIDRVGLSN
                     SNSELVGNFSKGMKRRLGIARALLNNPELLILDEPTN"
     CDS             9269..9970
                     /locus_tag="ctg51_13"
                     /transl_table=11
                     /translation="MREIKAIMWKELMQIQSRQKSVIVNSVCNLILIGMIGMMRLLSLR
                     SSGQDTKGMVTNIVIYVSIMCSYMALLTLLRFWQEKSNKTIETLISMPIGVEAIVLAKT
                     LIPVLLACVIGFIDTSVMFLSVWILYGNIKISLIYVIGVQIMFTILVGVPYSIINAYAM
                     WCMDLTYSKMVQGGSSFAYIAVLGTMFINNNSDLFYLPRVIAIVSGVLMAIALVMLIKF
                     DKEKIVLRFLD"
     CDS             10038..10238
                     /locus_tag="ctg51_14"
                     /transl_table=11
                     /translation="MKPINDMSAWSWGNFVCGIFCGVAGGACALAGCAVDGPSPVADAA
                     LAKLAVGGGVASAAFVGGLAG"
     CDS             10541..11314
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Abi"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg51_15"
                     /sec_met_domain="Abi (E-value: 4.4e-16, bitscore: 49.4,
                     seeds: 823, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="VVSAVIVILIYILSQVLVQYIYAFVVYFRNLDPNRDFAEALFPAI
                     SNINNNKDIFSLITIALAVVIIYYHYCRRKGQYGISFNVKSLKSVDCIIWMIFGVTLST
                     CFYMILVFFNIIDIDVSGVEIGIRYFLVSCMVVPVFEEWLYRNVVMTILLKNMHIIPTI
                     IIQAFLFSVIHASNTQKIYTFFLALVLGVVMIETNNFIVTSYIHIVFNVVGLGVIDVYS
                     LNTVARGVVLFVSTVISVVLLLYEIGKCNKNKQLN"
     PFAM_domain     10925..11176
                     /aSDomain="Rce1-like"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF02517.18"
                     /description="Type II CAAX prenyl endopeptidase Rce1-like"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg51_15_0010"
                     /evalue="2.10E-13"
                     /label="ctg51_15"
                     /locus_tag="ctg51_15"
                     /protein_end="212"
                     /protein_start="128"
                     /score="50.5"
                     /tool="antismash"
                     /translation="YFLVSCMVVPVFEEWLYRNVVMTILLKNMHIIPTIIIQAFLFSVI
                     HASNTQKIYTFFLALVLGVVMIETNNFIVTSYIHIVFNV"
     CDS             complement(11464..11667)
                     /locus_tag="ctg51_16"
                     /transl_table=11
                     /translation="MAVVNNLKEIRESRGLLQEDLASATGFCTKTIGRVERGERAPSAE
                     FMLQIAAYFNLLVEDIFKLEEH"
     PFAM_domain     complement(11500..11649)
                     /aSDomain="HTH_3"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF01381.24"
                     /description="Helix-turn-helix"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg51_16_0011"
                     /evalue="3.00E-12"
                     /label="ctg51_16"
                     /locus_tag="ctg51_16"
                     /protein_end="56"
                     /protein_start="6"
                     /score="46.5"
                     /tool="antismash"
                     /translation="LKEIRESRGLLQEDLASATGFCTKTIGRVERGERAPSAEFMLQIA
                     AYFNL"
     CDS             11743..12369
                     /locus_tag="ctg51_17"
                     /transl_table=11
                     /translation="MQKISNFIRMILSNHFSKYIETIIFINRNRRVFLVEGNKKYAILI
                     LFLYIFLRTNNRELCLKKNMVKIFISIFLYEIFVMLIMLIFFIAPRESKEISVINLVVL
                     LIINTLQLFMLAMISNMLVLFKSEVVCNLGNIILTTAPLVIVGALYEERKQWIIFAKWF
                     PLNLGNYVYLNSMKENIISILLMIVINFVLYYATAYGLKKYELLE"
ORIGIN
        1 taaaaactat aaaaggttac aaaaaatcag aagaagaaaa gaagacttat atgtatagta
       61 cgaattatta ttcagtatat tctgcctcaa aagaacaaaa agtcgttaaa ttgagtaaga
      121 aaaaaatata taatgaggaa tataaatata gggatttgaa agatcaagtt atacttactt
      181 cagataagaa tgtagttgat gattacaata aaatgagtga gaaattcgtt caaaaatact
      241 ttgaatcata gttttatata aatcaaaaat tagggtttta aaaatttaga atgcaaaaat
      301 gtattcaaca gaaattattt ctttcctaga atgaaaaatc gattttgaaa cctttgagaa
      361 gaagagagat actctgcaga atcagctcag tgaaaagaag attgagattg tagctttaga
      421 aaacatagga aattctaaac ttgatttaga agatcgtatt tcattcatgc gtgaaaaatt
      481 ggagacggag gataccataa aagaatttga tcgtcaagta tttgaaagta tagtggatta
      541 tgtcatcgtg ggaggttata ataaagaggg aaatgctgat ccgtcgaaga taacgtttgt
      601 ttatcggact ggattcaagg attgtaaaga tgctaatcac tttaaaccag agagacttaa
      661 tgcgtccaag aagaaaaatg gttctggcag tcataacaaa gaggtatgcc agagtgatga
      721 tacatcttct aatagttctt taagtcattc tggcttgcag tcacttatac cagacgactc
      781 caacactttg cagtcaaata catcacccga tgcatgtgga agtcgtcaca tgtctacaaa
      841 gggtgaattc gtagaaatcc ttgagtttac aggtgttaga gagtaattag tatcaatgac
      901 tatctttttt aattcccgga tttatgagag tatatttatt tttgggagga taatttactt
      961 tgcctttttt gatgaatatc atgataatcg tatttgcctc tggacaaaag gatactcaac
     1021 taaataagga actcaaaaga gtgtggaaat ccattggagg atgcttttgc actctttttg
     1081 tttgcaatca gacatgtaga ttataagttg aaataatatg ccaaattaga tacaatatag
     1141 gtacaaacgg atatcgtaaa attacattat aagattttat atcggagaat gtgatgacag
     1201 atagagtatt tgagacattt ggacaaaggt tacgtaagtg ccggaataat aagaatatga
     1261 ccaaggaaca ggtggcggaa gctttagggg ttacgcagga ttattacggc aaaattgaaa
     1321 atgataagtt gatgctgtca tatgatatat tagagcagtt atatcgtatg gaatgggata
     1381 tcggctacat tataacagga tgtgaattag ggcaagaaga gagcttgtgg ctgatgaaag
     1441 atattatgga tgtggagttt gataaaaatc agcaaagttt gcggttttgg ttatacgtta
     1501 tggagagtca gataaataag ggagtattgc aaaccatcat ttttctttga tgtgcggagg
     1561 catatgtatt atatagtggg ggattttttg atggcgatgg ataatggaaa aggtctgcag
     1621 ggaaaagaag tacttcagca tgcaatgaaa ttaatggagc ttttgtaaag aagcagtgtt
     1681 ttggcgatgc ttgaatattt gcaaaacaaa ataccgtatt gaaatatatg gaggtgggga
     1741 atttgctgag gatagcgata tgtgatgatg ataagaaaga tatagaatat atggaagaaa
     1801 taatttcaga aagtggaatg gataaaaatg aggtgtattt tcacgagtat ggttcgggag
     1861 aggatttatt aatgcatatt aaagaacttc caagttgtga tttgctgata cttgatatgc
     1921 agatgggaga aatggatgga catgaaacag cagcagcttt tcggaaagtt tttccgaaaa
     1981 caactttagt tttttggtcc ggtgtatgca ggccgacaga tgaatcattt aaggcaacac
     2041 catttcgata cttatttaaa aattatagta aggaaatgat gatacaagaa atgcaggctg
     2101 ttgtgagaga agtgaagtcc aagcagacag tcccttatat tattggaaac tattattaca
     2161 atactgtccg ttttgaaccg gatgatatct tgtatataga aaattatcgt tttggcagta
     2221 ttattcatcc gtatcaggaa aaagtagatt atgattttga aaaaaagggt gatattaaaa
     2281 caaaaaagaa attaaatgag ctgtatgaag aattacagcc ctttggtttt gaatatgcac
     2341 ataatagcta tattgtgaat atgaattatg ttacaaaaat gtcttcggag ggggatttaa
     2401 aacttaaaga cgatactttg ttaagaattt cgcgttcaaa acaaaagtct ttccgggagg
     2461 cattttcaga attaatggga tataaatatt gaatgaggag aggaacatgg aacttataga
     2521 ttgtgcaatt ttgctggcaa gttgtgcggt ggaaatttat tttctccatt ctttttttgg
     2581 aatgttgttt gagaagagag tatggtttgc tgacaataga ttaagaatct ggttgtttaa
     2641 tatatttgca gtgtttttgt tatatctttg taatatgatt ggaaatggag atactaattt
     2701 gattgtagtt ccaattattt catggatata tacatacata ctctttcatg gtaagtttgg
     2761 aagccggatg ctatatttta ttatggcttt ttctattatt tgggggagtg aatggatata
     2821 tgctatcata cttggattag ggaatgatgc atacaaaact atgtcagaaa tgccgtttac
     2881 agtgttatct ttaaaattat tgacgtatat catattcatt atagtagaac aattaatcgg
     2941 aacaaagaag aaaaagatgg ataatagaat ttttctcaaa tatctatgtc tgcccattgc
     3001 cagttttggc atgatgactg gtgtttttta ttctggaatt gacttttcca ctggtgttgg
     3061 gattcgtatg ctgatgactg tctgctatat cttaatgctt tttggaaata ttttaatatt
     3121 ttatgcattt aatcaatatt cagatgaaat gaatagcaat atggaaaatc aagcactcat
     3181 tatgaagcag caggcagatc ttgaatattt tatgcagatg gcggaaagtc aggaacggca
     3241 taatgaattt atacataata tcagccatta cttaaggacg attaatcagt tcgcacagga
     3301 aaatgactgt caaagcatag ttaagatagt gggtgaactt gacagccata tggaagcctc
     3361 tgaaatgaaa ttgtattcga attatcatgt actaaatgct atactttctg aaaaggggcg
     3421 tttggcagaa aaacagaaca taatatttga tgcttatgtg gaacccggaa ttgtgctaga
     3481 tatggtagag gatgttgatt tgattgcaat gcttggaaat cttttggata atgctttacg
     3541 ggcagcaaag acttataaag aggaagcgtt tgtaaatgtc aggatgtata tgcaggatat
     3601 tagaggattt tgtgtcctaa aaatagtaaa cagctattcc ggtgacatca taatgaaaga
     3661 ggatacattt atatcaacta aaaaggagaa ggggattcat ggactaggga taaaaagtgt
     3721 gaatagaatg gctgaaaaat atggtggata tttaacatgt aaggcaaagg atgatgtgtt
     3781 tgaagctgtt ttattgatat ctacaaatta atctacaagt aataatccgt gtaacagatg
     3841 tgatgagtaa aagacattac atctgtcttt ttttgcaaaa acgtatactc attttgcaaa
     3901 aatcgacggt cttattgaaa aagaaattat gaaatagtaa tatataaaaa aacgaaggag
     3961 gaaatgtcaa atgagcaaat tcaaaaaaga aaatgtaatg aaagtaatta actgtctggc
     4021 actggtatta gtggctgctt cggctaactc ggcttgcttt ttttattttc atcagccgga
     4081 atttccgaaa gctgcagata agtttagaca gataggcaat gattgaaaaa gctgcggatt
     4141 ggtacgcaag gaaacagatt agagcaggaa ttattaagga agaggatagg gatgtttata
     4201 agtatggata tatacttgct atggaaatgg gaattaatat tctcatatct ggaatgatgg
     4261 cattcatatt caatatgtta gaatgtctaa ttgtgttttc ttgtgtgttt attccgctta
     4321 gaacattttg tggaggatgg cacgcttcta aaagctggat atgttctttg atttctaatg
     4381 ttacaattgc aggaattatg atagtagaaa aatatcaaat ttggacgttt ggcatttggg
     4441 tggcagtgat tattgaattg gtatgctcta tcgctgtatg gaacatggca ccaatcgagc
     4501 ataagaataa accactaagt aatcaggaaa agaaagctta taggaaaata tgcaaggtaa
     4561 tgtatgttgt acagttgggt ttgatgtttc ttttttattg tatcggaagg acagatatac
     4621 tgcaaacagg agtgatggca catattatag ttgttctatc gttacttatg ggggcagtcg
     4681 atataaaaaa agaaagaatt atatttgaaa aatgagggac acaagaaaag aattatacga
     4741 tatacatacg tgaaacagca tgatgaaaca gactgtgcgg cggcattctt tgcgaaggaa
     4801 atcgattagc gcagtaccag tttattcaaa aacactctca agaattcggg gtcagatggc
     4861 ttcttagaag gtttaatatc tgtccaaatg cttattacaa ttacttgaaa aattgtaaat
     4921 cagagtacag gaaaatcaag tcatccatac aacgaaggat tgttgaaata taccacgaga
     4981 acgatggagt tcctgggtac cgaatgatgc gtaattatct ggttctggaa aatataattt
     5041 actcatatac tacaattttt aagtatatgc acgaactagg cttacaatct attgtcagac
     5101 gtaaaaaacc agaatacaaa aaagggaaaa gccaacaaag tatttcctaa tttagtcaat
     5161 cgagaattta atgtaacaga accaaacaaa gtatggtgta ctgattttac atatatgcca
     5221 agaccaaacg gttccatacg ctataattgt tcaattattg acctttttga tcgcagtgcc
     5281 gttgctacat taaatggatc aaatataact gcagaattag caatagcaac gcttcagaaa
     5341 gcactagacg tacataaacc aggaaaagga ataattctgc attcagacca aggaagccag
     5401 tatacatcaa aagaattcaa tgaattctgt gaaaaaatca tgtgtaacaa agtatgagtc
     5461 gtgctggatg tccttatgat aatgctccaa tggagcgatt ttacaacata ttcaaaagtg
     5521 aattctacta tctttattca ttcacatcag atgcagagat agatcagaag actttagaat
     5581 tcatttatgg aaaatataac cataaaagac cacacacaca taatggaggt tgcacttctc
     5641 atgcgactcg ttatgctgaa tagaggaaac tatcataaag tgttacaatt ttgcttgaca
     5701 acaacaatag gagatgattg attgaatatg aaacttaatg gaaaagaatt tacaacaaaa
     5761 agtggtgctg aatatgttta tctttcagat atgaatattg tattatccaa aaatgcaata
     5821 gaggcttatc cgcaaagaag agaattgtta agtcaaattc caggttataa aaaaactaat
     5881 gagtactatg attgttatcg tgaatatact cctgaagaga taaaattgga gattatgaaa
     5941 aatggattgt gtgaattggc tattgaagtt acttctgcat gtaattttag atgcgaatat
     6001 tgtgtttatt caggaaaata tgaaaatcag cgtcttcacg attatcaaaa catggatgtt
     6061 actacagtgt ttaaagccat tgataaatat tatgaactta tagaagaggg aattgaatac
     6121 aactcagata gaacaccggt aatttcttat tatggaggag aaccacttgt gaaatttgat
     6181 ttgataaaga agtgcacgga atatgcaaaa gaaaaatttg ataataatat tttgttcaca
     6241 ataactacta acggctccct tatgaatgat gacgtgatag atttttttgt gaatgaaaaa
     6301 tttaatgttg tagttagcat agatggttac aaggaaaacc ataatcgtaa tcgaaaagat
     6361 gtaaagggga atcctacttt tgatagtgtt attgaaaatg ctagaaagct atttcttaag
     6421 caagggacac cagtttttac tagtgtagtc ttcgattacg acacagattt tgttttgatg
     6481 gagaagtttt ttagagacaa tgattttctt gtgtgtctct ccataaatag tgttaatccg
     6541 tacagtacaa cttactttga taaatatact gttgatagtt atgatagatt taaagcaaaa
     6601 cttgatattc ttatgaaaga attcgaatta tcagttgttg ataatgaagc aaatcctctt
     6661 gcatttatgt cgcgaacttt cggagatata tgtacatcaa gttttatgag gcaatgtgat
     6721 attagcaaaa agaataataa aattataaag catactggag cttgtgttcc aggtaataag
     6781 atttttgtgg atgtaaatgg cgatttttac atatgtgaaa aggtcggtag aagtattgtg
     6841 ataggtaatg tagaagaagg tatcaactat gaaaagtgtg cacaagttgt gaatagatat
     6901 aataacttgg tggtgcacaa atgtcgcaac tgtgtaataa gaaataattg caaacgttgt
     6961 tatgtaagta ttgatatgga tgaaaataag ataaatatac ctgctgaaag ttgtaaaaag
     7021 cagattgaag attactttgc ggatttaagt tttgcatatt cgatttttga gtcaaatccg
     7081 aaatggatag gtaggtattt tagtgaatat tatgatgcaa taaatgatat gatggtgatg
     7141 ttaagatgaa aaagtatttt aagctatttg aagaatgtta tattgtttct ggaaaggaca
     7201 agtatacatt atataatgtt cttacgggaa atatatatga gattgatgaa aaaagaggaa
     7261 agttttgtct gttgtcagag aataatatgg atatagaaaa tgcgtgtaat aattctggtt
     7321 tgctactgtc agaagctaaa atattcatta aggaaatgga atcagctacg cttggtatga
     7381 tgagtgattt tccaatagct atggataagt taaatatcct tcccaaatgg acagaaaaaa
     7441 tgttttttaa acagtctcat ggtataaata aagctacaat cggaatggac tatgattgca
     7501 gtaatagttg taatttttgt ggaaatgatg ctgtaactaa caggtacaaa tgttggtcgt
     7561 gcaattctac tagtagatct ccaattgcag atgatgttgc ttttaggata attgatatta
     7621 tatcagagag agactgtaag gagttgtatt tgaaagaggg ggatttatta tcagattggg
     7681 ggaagacatt aaggattgtt gattatgctc tgaatagagg tattgaaaaa gtgttgctga
     7741 acataataca tccaattgat gatatgacca taattaatga tatgcgagtt agaaatatat
     7801 ctctagtgct acaaagatat attgagaaaa aaaaacaaat agagttgatt atgtcggaga
     7861 gtagaaaata tgaaggattg gatgtaacat acatattact taccgaactg gataacaagg
     7921 aaactataat gcaagtggct cagaatatca gccagatgta ttcgtataag ttattaatag
     7981 attttatgat cccaaataaa ttagaaaatg tttctaagga atattttgat attgaaagaa
     8041 caattggaaa aattgattta gttagttatt ccataagaca atttcataat gaatgttttt
     8101 ataaaaattg ttacttcgat aaggaaggaa acgtttatcc atgtgctggt cttaaaaata
     8161 gaaagtatgg agatatagat tctatgcccg aaacatttag aagtgaaaac cttggaaatt
     8221 actggaatat gtcattaagc aaaaaacagg aatgcaagga gtgttctatg agattcgcat
     8281 gtaacaattg tgagtcactt aattatacat taactggtag ccatgataga aatgtattat
     8341 gtgtaaaaac tataatttga ggagttaata atgaaaaatg taatcgaatt taaaggtgtt
     8401 acaaagaaat atggagagaa aactgttatt gatgatgtga catttactgt tgaaaaaggt
     8461 gatatatttg ggtatcttgg accaaacggt tctggtaaaa caacaagtat tcgaatgatg
     8521 ttagatcttc tccatgtttc gtcaggtgaa atattattat ttggaaagcc aattggtaaa
     8581 aatgacataa gaaaaaaaat aggtatatgt cttgatgatg aggggtttta tccagaacta
     8641 actgcgtatc aaaatcttga atattttgat cgtatatata atgatgcaag tggtagaaag
     8701 aaaagaattg acgaatttat tgatagagta ggactgagta atagtaactc agaactagtt
     8761 ggcaattttt ctaaaggaat gaaacgtaga cttggaatcg ctcgtgcact attgaataat
     8821 ccagaactgt taatacttga tgaacctact aatggtcttg atccggatgg tcaaaaatat
     8881 gttagtgaat tacttatgta tttgtcaggg aaaactactg tttttcttag ttcacataat
     8941 ttgaatatta tagaagatgt gtgcaataaa gtggcgatta taaagaacag acttttgttt
     9001 tgtgacaaaa tggattcaat agcgtgtaat catactatat tatataatct gactttttct
     9061 aataaaaaag atagttatga gtttataaat caattagata cagtagatca cagtgttata
     9121 gatgacagac ttatagtaag ggttaatgaa gcagaacaac aactcgctga aaaattgata
     9181 aaagaacatg gattggtaat tgagtccaaa aaaaatagtg atagaaaact tgaaaatctt
     9241 tattttagtg tgttaaagga ggactagcat gagggagatt aaggctatta tgtggaaaga
     9301 acttatgcag attcaaagcc gacaaaaatc agtaatagtt aattctgtat gcaatttgat
     9361 attaattgga atgataggaa tgatgagatt gcttagcctt cgtagcagtg ggcaggatac
     9421 aaagggtatg gtgactaata ttgtgatata cgtatctatt atgtgtagct atatggcact
     9481 actgacgctt ttgagatttt ggcaggagaa aagtaataaa acaatagaaa cattaatttc
     9541 aatgccgata ggtgtagagg ctattgtatt agcaaaaacg ttaattccag tacttttagc
     9601 ttgtgtgatt ggctttatag acacttcggt aatgttcttg tcggtatgga tactgtatgg
     9661 gaatattaaa atttcattga tatatgttat cggagttcag ataatgttta caattcttgt
     9721 tggggttccg tacagtataa taaatgcata tgcaatgtgg tgtatggatt taacatactc
     9781 aaaaatggtt caagggggtt ctagcttcgc gtacatagct gttctaggga ctatgtttat
     9841 aaacaataat tcagatcttt tctatttgcc aagagtaata gctatagttt ctggtgtgtt
     9901 aatggctatt gctctggtaa tgctcattaa atttgataaa gagaaaattg tacttagatt
     9961 tctagattga taactgatat attcaattga tatcaattgt ttatatatac ctataaaatg
    10021 gaaagggggg aggaaatatg aaaccaatca atgatatgag tgcatggtca tggggaaatt
    10081 tcgtttgtgg tattttctgt ggtgtggcag gtggtgcttg tgcacttgca ggttgcgcag
    10141 ttgatggacc atcgcctgta gcagatgcag ctttagctaa gcttgcagtt ggtggaggag
    10201 ttgcaagtgc agcttttgta ggtggtttag caggataata tacctatatg ttctggataa
    10261 agcgcgaaag tatcttgttt atataaaatt aatattacat acgcaagaat aacataatcg
    10321 catttttaac caaagtttag ggtatatgca aggatgcgcg cggatttaat agctattgga
    10381 tttaagtaag gataaattaa atccgtcgcg taagcttgcg tatatatgaa gcaaatagac
    10441 atttgttaat gtgctatata ttagcaatga cgaattttat aatatggaat aagtcttaag
    10501 tagagaggta gatattagtg tgaaaaaatc aattttggct gtggtcagtg cagttattgt
    10561 cattttaata tatatattat ctcaagtatt agtacagtat atatatgctt tcgttgtata
    10621 ttttagaaat ttagatccaa atagagattt tgcagaagca ctatttcctg ctatttcaaa
    10681 tattaataat aataaagaca ttttttctct gattacaatt gcattagctg ttgtaattat
    10741 atattaccat tattgtagaa ggaagggaca atatggtatc tcgtttaatg ttaaaagttt
    10801 aaaatctgtt gattgtatta tatggatgat ttttggagta acgctttcga cttgttttta
    10861 tatgatactt gtatttttta atataataga tatagacgtt tctggagttg aaataggtat
    10921 acgctatttt ttagtatcat gcatggtggt tccagtattt gaagaatggc tttatagaaa
    10981 cgttgtaatg acaatattat tgaaaaatat gcacattatt ccaacgatta ttatacaagc
    11041 gtttttgttt tctgttatac atgctagtaa cactcagaaa atatatactt tttttttagc
    11101 gcttgtattg ggagtggtta tgatagagac gaataatttt attgtaacat cgtatattca
    11161 cattgttttt aatgttgttg gattaggagt aatagatgtg tattctttga atacggttgc
    11221 tagaggagta gtactttttg taagtacagt tattagtgta gtattgttgt tatatgaaat
    11281 aggaaaatgt aacaaaaaca agcagttaaa ctaactactc ataacgttag ttcaactgct
    11341 tgttttgtat gcgcttacgt tacaaaggca ataacaaatt ttaatttgca ggttaagtta
    11401 tagacagcat aaagaatgat tatatattaa atgaagtaaa aaatgtaaga gcaccgacca
    11461 aagtcagtgc tcttctaact taaagatatc ttccacaagc agattaaaat aggctgcaat
    11521 ctggagcata aattcagcgg atggtgcccg ttcaccacgt tccactctgc cgatagtttt
    11581 tgtgcagaac ccggtggcag aggctaaatc ctcttggaga agacctcgtg attcacgaat
    11641 ttctttaagg ttattaacga ccgccattgt aaacacctac tttcatacat tcattattac
    11701 caaggataca gaaaatactg tcctaaaata cggactcgtt taatgcagaa aatctctaat
    11761 ttcattcgga tgattctttc caaccacttt tccaagtata tcgaaacgat cattttcatt
    11821 aacaggaata ggagggtatt tctcgttgag ggaaataaga aatacgccat ccttatcctc
    11881 tttttatata tttttttaag gactaataat cgagaattgt gtttgaaaaa aaatatggta
    11941 aagatattta tcagtatttt tttgtatgaa atatttgtta tgcttattat gctgattttt
    12001 tttatagcac ctagagagag taaagaaata tctgtaatta atcttgtggt gttattgatt
    12061 attaatacac ttcagttatt tatgttagcg atgatttcaa atatgctagt attattcaaa
    12121 tcagaagttg tttgcaattt aggaaatata atattaacaa cggcaccttt agttatagtt
    12181 ggagcattgt atgaagaaag aaaacaatgg attatttttg caaaatggtt tccgttaaat
    12241 ttaggtaatt acgtttactt aaattctatg aaagaaaata ttattagcat cttgctgatg
    12301 attgtaatta attttgtatt gtattatgcg acggcttacg gactgaagaa atatgagctt
    12361 ttagagtagt aggagaaaaa aatgaagatt aaagtagaaa atatagaaaa acagattaaa
    12421 ggtaatgaag tttta
//
