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Overview
1.1
1.2
1.3
1.4
1.5
1.6
1.7
1.8
1.9
1.10

### Identified secondary metabolite regions using strictness 'relaxed'

NZ_CP014842.1

Region | Type | From | To | Most similar known cluster | Similarity
--- | --- | --- | --- | --- | ---
Region 1.1 | lanthipeptide-class-ii | 353,029 | 379,990 | lichenicidin VK21 A1 / lichenicidin VK21 A2 | RiPP:Lanthipeptide | 100%
Region 1.2 | lassopeptide | 438,975 | 461,436 |
Region 1.3 | NRPS | 564,393 | 610,317 | bacillibactin | NRP | 53%
Region 1.4 | CDPS | 888,304 | 909,053 |
Region 1.5 | T3PKS | 2,004,143 | 2,045,240 |
Region 1.6 | terpene | 2,094,581 | 2,116,470 |
Region 1.7 | betalactone | 2,212,862 | 2,241,376 | fengycin | NRP | 53%
Region 1.8 | siderophore | 3,032,453 | 3,047,919 |
Region 1.9 | thiopeptide,RiPP-like | 3,169,947 | 3,211,238 | butirosin A / butirosin B | Saccharide | 7%
Region 1.10 | NRPS | 3,810,402 | 3,875,851 | lichenysin | NRP | 100%

Region | Type | From | To | Most similar known cluster | Similarity
--- | --- | --- | --- | --- | ---
Region 1.1 | lanthipeptide-class-ii | 353,029 | 379,990 | lichenicidin VK21 A1 / lichenicidin VK21 A2 | RiPP:Lanthipeptide | 100%
Region 1.2 | lassopeptide | 438,975 | 461,436 |
Region 1.3 | NRPS | 564,393 | 610,317 | bacillibactin | NRP | 53%
Region 1.4 | CDPS | 888,304 | 909,053 |
Region 1.5 | T3PKS | 2,004,143 | 2,045,240 |
Region 1.6 | terpene | 2,094,581 | 2,116,470 |
Region 1.7 | betalactone | 2,212,862 | 2,241,376 | fengycin | NRP | 53%
Region 1.8 | siderophore | 3,032,453 | 3,047,919 |
Region 1.9 | thiopeptide,RiPP-like | 3,169,947 | 3,211,238 | butirosin A / butirosin B | Saccharide | 7%
Region 1.10 | NRPS | 3,810,402 | 3,875,851 | lichenysin | NRP | 100%

No secondary metabolite regions were found in these records:
  NZ_CP014843.1

Compact view
NZ_CP014842.1 - Region 1 - lanthipeptide-class-ii
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 353,029 - 379,990 nt. (total: 26,962 nt) Show pHMM detection rules used
lanthipeptide-class-ii: cds(LANC_like and DUF4135)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
MIBiG comparison
KnownClusterBlast
Lanthipeptides
Pfam domains
TIGRFAM domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | lanthipeptide-class-ii | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000525.1 |  | 1.00 | RiPP | lichenicidin VK21 A1, lichenicidin VK21 A2 | Bacillus licheniformis
BGC0001229.1 |  | 0.34 | RiPP | SBI-06990 A1, SBI-06989 A2 | Streptomyces bingchenggensis BCW-1
BGC0000517.1 |  | 0.34 | RiPP | haloduracin β, haloduracin α | Bacillus halodurans C-125
BGC0000539.1 |  | 0.30 | RiPP | nukacin ISK-1 | Staphylococcus warneri
BGC0000523.1 |  | 0.29 | RiPP | lactocin S | Lactobacillus sakei
BGC0000504.1 |  | 0.27 | RiPP | cytolysin ClyLl, cytolysin ClyLs | Plasmid pAD1
BGC0001787.1 |  | 0.26 | RiPP | suicin 3908 | Streptococcus suis
BGC0001364.1 |  | 0.26 | RiPP | cinnamycin B | Actinomadura atramentaria DSM 43919
BGC0000561.1 |  | 0.26 | RiPP | thermophilin 1277 | Streptococcus thermophilus
BGC0000554.1 |  | 0.25 | RiPP | SRO15-3108 | Streptomyces filamentosus NRRL 15998

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000525.1 |  | 1.00 | RiPP | lichenicidin VK21 A1, lichenicidin VK21 A2 | Bacillus licheniformis
BGC0001229.1 |  | 0.67 | RiPP | SBI-06990 A1, SBI-06989 A2 | Streptomyces bingchenggensis BCW-1
BGC0000517.1 |  | 0.67 | RiPP | haloduracin β, haloduracin α | Bacillus halodurans C-125
BGC0000539.1 |  | 0.63 | RiPP | nukacin ISK-1 | Staphylococcus warneri
BGC0000523.1 |  | 0.62 | RiPP | lactocin S | Lactobacillus sakei
BGC0000504.1 |  | 0.61 | RiPP | cytolysin ClyLl, cytolysin ClyLs | Plasmid pAD1
BGC0001787.1 |  | 0.60 | RiPP | suicin 3908 | Streptococcus suis
BGC0001364.1 |  | 0.60 | RiPP | cinnamycin B | Actinomadura atramentaria DSM 43919
BGC0000561.1 |  | 0.59 | RiPP | thermophilin 1277 | Streptococcus thermophilus
BGC0000554.1 |  | 0.58 | RiPP | SRO15-3108 | Streptomyces filamentosus NRRL 15998

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.
Lanthipeptide predictions
Lists the possible core peptides for each biosynthetic enzyme, including the predicted class. Each core peptide shows the leader and core peptide sequences, separated by a dash.

#### Lanthipeptide(s) for ctg1_319 - Putative Class II

ctg1_320 leader / core peptide
  MSKKEMILSWKNPMYRTESSYHPAGNILKELQEEEQHSIAGG - DhbIDhbLDha Dhb CAILDhaKPLGNNGYLC DhbVDhbKECMPDha CN
ctg1_321 leader / core peptide
  MKTMKNSAAREAFKGANHPAGMVSEEELKALVGG - NDVNPEDhb DhbPADhb Dhb Dha DhaWDhb CIDhbAGVDhbVDhaADhaLCPDhb DhbKC Dhb DhaRC
allorf_0354436_0354504 leader / core peptide
  MLNDEMFHVNFG - AFFDha C CFDhaAC
allorf_0362763_0362888 leader / core peptide
  LMPTLNGKRLQLRRILNGG - HRDha DhaLPFIGIREDhaIACIDhaELDhaE
allorf_0353062_0353172 leader / core peptide
  MDSKYAGS - LHKIVVDhbLKMEVQRCKVFIRFAGNLDIF

#### Lanthipeptide(s) for ctg1_322 - Putative Class II

ctg1_320 leader / core peptide
  MSKKEMILSWKNPMYRTESSYHPAGNILKELQEEEQHSIAGG - DhbIDhbLDha Dhb CAILDhaKPLGNNGYLC DhbVDhbKECMPDha CN
ctg1_321 leader / core peptide
  MKTMKNSAAREAFKGANHPAGMVSEEELKALVGG - NDVNPEDhb DhbPADhb Dhb Dha DhaWDhb CIDhbAGVDhbVDhaADhaLCPDhb DhbKC Dhb DhaRC
allorf_0362763_0362888 leader / core peptide
  LMPTLNGKRLQLRRILNGG - HRDha DhaLPFIGIREDhaIACIDhaELDhaE

#### Legend:

Dha: Didehydroalanine
Dhb: Didehydrobutyrine
Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
Lanthipeptides
Core peptide predictions
Lists the possible core peptides in the region. Each core peptide lists the number of lanthionine bridges, possible molecular weights, and the scores for cleavage site prediction and RODEO.

ctg1_320 - Class II
  Cleavage pHMM score: 3.30
  RODEO score: 0
  Monoisotopic mass: 3230.6 Da
  Molecular weight: 3232.8 Da
  Number of bridges: 4
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    3250.8 Da N = 1
    3268.8 Da N = 2
    3286.9 Da N = 3
    3304.9 Da N = 4
ctg1_321 - Class II
  Cleavage pHMM score: 1.50
  RODEO score: 0
  Monoisotopic mass: 3632.8 Da
  Molecular weight: 3635.0 Da
  Number of bridges: 4
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    3653.0 Da N = 1
    3671.1 Da N = 2
    3689.1 Da N = 3
    3707.1 Da N = 4
    3725.1 Da N = 5
    3743.1 Da N = 6
    3761.2 Da N = 7
    3779.2 Da N = 8
    3797.2 Da N = 9
    3815.2 Da N = 10
    3833.2 Da N = 11
allorf_0362763_0362888 - Class II
  Cleavage pHMM score: -7.00
  RODEO score: 0
  Monoisotopic mass: 2353.3 Da
  Molecular weight: 2354.7 Da
  Number of bridges: 1
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    2372.7 Da N = 1
    2390.7 Da N = 2
    2408.7 Da N = 3
    2426.7 Da N = 4
ctg1_320 - Class II
  Cleavage pHMM score: 3.30
  RODEO score: 0
  Monoisotopic mass: 3230.6 Da
  Molecular weight: 3232.8 Da
  Number of bridges: 4
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    3250.8 Da N = 1
    3268.8 Da N = 2
    3286.9 Da N = 3
    3304.9 Da N = 4
ctg1_321 - Class II
  Cleavage pHMM score: 1.50
  RODEO score: 0
  Monoisotopic mass: 3632.8 Da
  Molecular weight: 3635.0 Da
  Number of bridges: 4
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    3653.0 Da N = 1
    3671.1 Da N = 2
    3689.1 Da N = 3
    3707.1 Da N = 4
    3725.1 Da N = 5
    3743.1 Da N = 6
    3761.2 Da N = 7
    3779.2 Da N = 8
    3797.2 Da N = 9
    3815.2 Da N = 10
    3833.2 Da N = 11
allorf_0354436_0354504 - Class II
  Cleavage pHMM score: -4.30
  RODEO score: 0
  Monoisotopic mass: 1048.4 Da
  Molecular weight: 1049.2 Da
  Number of bridges: 2
allorf_0362763_0362888 - Class II
  Cleavage pHMM score: -7.00
  RODEO score: 0
  Monoisotopic mass: 2353.3 Da
  Molecular weight: 2354.7 Da
  Number of bridges: 1
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    2372.7 Da N = 1
    2390.7 Da N = 2
    2408.7 Da N = 3
    2426.7 Da N = 4
allorf_0353062_0353172 - Class II
  Cleavage pHMM score: -7.20
  RODEO score: 0
  Monoisotopic mass: 3298.9 Da
  Molecular weight: 3301.0 Da
  Number of bridges: 1

NZ_CP014842.1 - Region 2 - lassopeptide
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 438,975 - 461,436 nt. (total: 22,462 nt) Show pHMM detection rules used
lassopeptide: (PF13471 and Asn_synthase or micJ25 or mcjC)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
MIBiG comparison
KnownClusterBlast
Lasso peptides
Pfam domains
TIGRFAM domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | lassopeptide | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001634.1 |  | 0.30 | RiPP | keywimysin | Streptomyces sp. NRRL F-5702
BGC0000575.1 |  | 0.29 | RiPP | lariatin | Rhodococcus jostii
BGC0001549.1 |  | 0.29 | RiPP | citrulassin B | Streptomyces aurantiacus JA 4570
BGC0001552.1 |  | 0.29 | RiPP | citrulassin F | Streptomyces avermitilis MA-4680 = NBRC 14893
BGC0001496.1 |  | 0.28 | RiPP | actinokineosin | Actinokineospora spheciospongiae
BGC0000571.1 |  | 0.28 | RiPP | burhizin | Paraburkholderia rhizoxinica HKI 454
BGC0001889.1 |  | 0.27 | RiPP | fusilassin | Thermobifida fusca YX
BGC0001645.1 |  | 0.26 | RiPP | lagmysin | Streptomyces sp. NRRL S-118
BGC0001356.1 |  | 0.26 | RiPP | paeninodin | Paenibacillus dendritiformis C454
BGC0001551.1 |  | 0.25 | RiPP | citrulassin E | Streptomyces glaucescens

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001634.1 |  | 0.64 | RiPP | keywimysin | Streptomyces sp. NRRL F-5702
BGC0000575.1 |  | 0.63 | RiPP | lariatin | Rhodococcus jostii
BGC0001549.1 |  | 0.62 | RiPP | citrulassin B | Streptomyces aurantiacus JA 4570
BGC0001552.1 |  | 0.62 | RiPP | citrulassin F | Streptomyces avermitilis MA-4680 = NBRC 14893
BGC0001496.1 |  | 0.62 | RiPP | actinokineosin | Actinokineospora spheciospongiae
BGC0000571.1 |  | 0.62 | RiPP | burhizin | Paraburkholderia rhizoxinica HKI 454
BGC0001889.1 |  | 0.60 | RiPP | fusilassin | Thermobifida fusca YX
BGC0001645.1 |  | 0.60 | RiPP | lagmysin | Streptomyces sp. NRRL S-118
BGC0001356.1 |  | 0.60 | RiPP | paeninodin | Paenibacillus dendritiformis C454
BGC0001551.1 |  | 0.58 | RiPP | citrulassin E | Streptomyces glaucescens

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.

No matches found.

Lasso peptide predictions
Lists the possible core peptides for each biosynthetic enzyme, including the predicted class. Each core peptide shows the leader and core peptide sequences, separated by a dash.

#### Lassopeptide(s) for ctg1_408 - Putative Class II

ctg1_408 leader / core peptide / cleaved tail
  MRKLESAQVKSYGSFLTVTL - S K K S K P G DGKFGRGVKRG

#### Legend:

Red: Putative macrolactam
Purple: Putative cleaved off residues
Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
Lasso peptides
Core peptide predictions
Lists the possible core peptides in the region. Each core peptide lists the number of disulfide bridges, possible molecular weights, and the scores for cleavage site prediction and RODEO.

ctg1_408 - Class II
  Cleavage pHMM score: -6.40
  RODEO score: 19
  Monoisotopic mass: 1870.1 Da
  Molecular weight: 1871.1 Da
  Number of bridges: 0

NZ_CP014842.1 - Region 3 - NRPS
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 564,393 - 610,317 nt. (total: 45,925 nt) Show pHMM detection rules used
NRPS: cds(Condensation and (AMP-binding or A-OX))

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
NRPS/PKS domains
MIBiG comparison
KnownClusterBlast
NRPS/PKS modules
Pfam domains
TIGRFAM domains
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
A glossary is available here.
Selected features only
Show module domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | NRPS | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001185.1 |  | 0.56 | NRP | bacillibactin | Bacillus velezensis FZB42
BGC0000401.1 |  | 0.55 | NRP | paenibactin | Paenibacillus elgii B69
BGC0000309.1 |  | 0.35 | NRP | bacillibactin | Bacillus subtilis subsp. subtilis str. 168
BGC0001615.1 |  | 0.34 | NRP | hexose-palythine-serine, hexose-shinorine | Heteroscytonema crispum UCFS10
BGC0000457.1 |  | 0.31 | NRP | vicibactin | Rhizobium etli CFN 42
BGC0001149.1 |  | 0.30 | NRP, Saccharide | brabantamide A | Pseudomonas sp. SHC52
BGC0001833.1 |  | 0.28 | NRP | icosalide A, icosalide B | Burkholderia gladioli
BGC0001132.1 |  | 0.28 | NRP | xenotetrapeptide | Xenorhabdus nematophila ATCC 19061
BGC0000417.1 |  | 0.28 | NRP | rhodochelin | Rhodococcus jostii RHA1
BGC0001825.1 |  | 0.27 | NRP | xenematide | Xenorhabdus nematophila AN6/1

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001185.1 |  | 0.82 | NRP | bacillibactin | Bacillus velezensis FZB42
BGC0000401.1 |  | 0.82 | NRP | paenibactin | Paenibacillus elgii B69
BGC0000309.1 |  | 0.68 | NRP | bacillibactin | Bacillus subtilis subsp. subtilis str. 168
BGC0001615.1 |  | 0.67 | NRP | hexose-palythine-serine, hexose-shinorine | Heteroscytonema crispum UCFS10
BGC0000457.1 |  | 0.65 | NRP | vicibactin | Rhizobium etli CFN 42
BGC0001149.1 |  | 0.64 | NRP, Saccharide | brabantamide A | Pseudomonas sp. SHC52
BGC0001833.1 |  | 0.61 | NRP | icosalide A, icosalide B | Burkholderia gladioli
BGC0001132.1 |  | 0.61 | NRP | xenotetrapeptide | Xenorhabdus nematophila ATCC 19061
BGC0000417.1 |  | 0.61 | NRP | rhodochelin | Rhodococcus jostii RHA1
BGC0001825.1 |  | 0.61 | NRP | xenematide | Xenorhabdus nematophila AN6/1

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.
Module view
Shows module structures for each candidate in NRPS- and PKS regions. Genes are shown in predicted order, and are only present when containing at least one complete module. A domain glossary is available here.
Legend
Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
NRPS/PKS products
NRPS/PKS monomers
Predicted core structure(s)
Shows estimated product structure and polymer for each candidate cluster in the region. To show the product, click on the expander or the candidate cluster feature drawn in the overview.
For candidate cluster 3, location 564392 - 610317:
Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:
  (gly - thr)

Direct lookup in NORINE database: strict or relaxed
Link to NORINE database query form
NRPS/PKS monomer predictions
Shows the predicted monomers for each adynelation domain and acyltransferase within genes. Each gene prediction can be expanded to view detailed predictions of each domain. Each prediction can be expanded to view the predictions by tool (and, for some tools, further expanded for extra details).

ctg1_544: dhb
  Search NORINE for peptide: strict or relaxed
  AMP-binding (31..435): dhb
  NRPSPredictor2: dhb
  SVM prediction details:
    Predicted physicochemical class:
      hydrophobic-aromatic
    Large clusters prediction:
      dhb, sal
    Small clusters prediction:
      dhb, sal
    Single AA prediction:
      dhb
  Stachelhaus prediction details:
    Stachelhaus sequence:
      PLPgQGVVNK
    Nearest Stachelhaus code:
      dhb
    Stachelhaus code match:
      90% (moderate)
ctg1_546: gly - thr
  Search NORINE for peptide: strict or relaxed
  AMP-binding (465..861): gly
  NRPSPredictor2: gly
  SVM prediction details:
    Predicted physicochemical class:
      hydrophobic-aliphatic
    Large clusters prediction:
      gly, ala, val, leu, ile, abu, iva
    Small clusters prediction:
      gly, ala
    Single AA prediction:
      gly
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DILQLGLIWK
    Nearest Stachelhaus code:
      gly
    Stachelhaus code match:
      100% (strong)
  AMP-binding (1521..1937): thr
  NRPSPredictor2: thr
  SVM prediction details:
    Predicted physicochemical class:
      hydrophobic-aliphatic
    Large clusters prediction:
      ser, thr, dhpg, hpg
    Small clusters prediction:
      thr
    Single AA prediction:
      thr
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DFWNIGMVHK
    Nearest Stachelhaus code:
      thr
    Stachelhaus code match:
      100% (strong)

NZ_CP014842.1 - Region 4 - CDPS
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 888,304 - 909,053 nt. (total: 20,750 nt) Show pHMM detection rules used
CDPS: (CDPS or cycdipepsynth)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
NRPS/PKS domains
MIBiG comparison
KnownClusterBlast
Pfam domains
TIGRFAM domains
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
A glossary is available here.
Selected features only
Show module domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | CDPS | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001184.1 |  | 0.21 | Other | bacilysin | Bacillus velezensis FZB42
BGC0000888.1 |  | 0.21 | Other | bacilysin | Bacillus sp. CS93
BGC0001514.1 |  | 0.16 | Other | aristeromycin | Streptomyces citricolor
BGC0000719.1 |  | 0.16 | Saccharide | tobramycin | Streptoalloteichus hindustanus
BGC0000720.1 |  | 0.15 | Saccharide | tobramycin | Streptoalloteichus tenebrarius
BGC0000622.1 |  | 0.14 | RiPP | megacin | Bacillus megaterium
BGC0001782.1 |  | 0.14 | Other | spiroindimicin A, spiroindimicin B, spiroindimicin C, spiroindimicin D, indimicin A, indimicin B, indimicin C, indimicin D, indimicin E, lynamicin A, lynamicin D, lynamicin F, lynamicin G | Streptomyces sp. SCSIO 03032
BGC0001140.1 |  | 0.13 | Terpene | platensimycin, platencin | Streptomyces platensis
BGC0001335.1 |  | 0.13 | Alkaloid | borregomycin A, borregomycin B, borregomycin C, borregomycin D | uncultured bacterium
BGC0000866.1 |  | 0.13 | Other | polyhydroxyalkanoate | Burkholderia sp. DSM 9242

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001184.1 |  | 0.54 | Other | bacilysin | Bacillus velezensis FZB42
BGC0000888.1 |  | 0.54 | Other | bacilysin | Bacillus sp. CS93
BGC0001514.1 |  | 0.46 | Other | aristeromycin | Streptomyces citricolor
BGC0000719.1 |  | 0.46 | Saccharide | tobramycin | Streptoalloteichus hindustanus
BGC0000720.1 |  | 0.45 | Saccharide | tobramycin | Streptoalloteichus tenebrarius
BGC0000622.1 |  | 0.44 | RiPP | megacin | Bacillus megaterium
BGC0001782.1 |  | 0.43 | Other | spiroindimicin A, spiroindimicin B, spiroindimicin C, spiroindimicin D, indimicin A, indimicin B, indimicin C, indimicin D, indimicin E, lynamicin A, lynamicin D, lynamicin F, lynamicin G | Streptomyces sp. SCSIO 03032
BGC0001140.1 |  | 0.42 | Terpene | platensimycin, platencin | Streptomyces platensis
BGC0001335.1 |  | 0.42 | Alkaloid | borregomycin A, borregomycin B, borregomycin C, borregomycin D | uncultured bacterium
BGC0000866.1 |  | 0.42 | Other | polyhydroxyalkanoate | Burkholderia sp. DSM 9242

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.

No matches found.

Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
NZ_CP014842.1 - Region 5 - T3PKS
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 2,004,143 - 2,045,240 nt. (total: 41,098 nt) Show pHMM detection rules used
T3PKS: (Chal_sti_synt_C or Chal_sti_synt_N)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
MIBiG comparison
KnownClusterBlast
Pfam domains
TIGRFAM domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | T3PKS | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000282.1 |  | 0.36 | Polyketide | alkylresorcinol | Streptomyces griseus subsp. griseus NBRC 13350
BGC0001831.1 |  | 0.20 | Polyketide | alkylpyrone-407, alkylpyrone-393 | Myxococcus xanthus DK 1622
BGC0001475.1 |  | 0.17 | Polyketide | aspterric acid | Aspergillus terreus NIH2624
BGC0001928.1 |  | 0.16 | Other | (2R,3S,4S)-5-fluoro-2,3,4-trihydroxypentanoic acid | Streptomyces sp. MA37
BGC0001647.1 |  | 0.12 | Polyketide | lagunapyrone A, lagunapyrone B, lagunapyrone C | Streptomyces sp. MP131-18
BGC0001289.1 |  | 0.12 | RiPP | penisin | Paenibacillus ehimensis
BGC0001686.1 |  | 0.11 | NRP | N-octanoyl-Met-Phe-H | Clostridium sp. CAG:567
BGC0001964.1 |  | 0.09 | Polyketide | alkylpyrone-407, alkylpyrone-393 | Cystobacterineae bacterium
BGC0001663.1 |  | 0.09 | Polyketide | merocyclophane C, merocyclophane D | Nostoc sp. UIC 10110
BGC0000284.1 |  | 0.08 | Polyketide | phenolic lipids | Azotobacter vinelandii DJ

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000282.1 |  | 0.69 | Polyketide | alkylresorcinol | Streptomyces griseus subsp. griseus NBRC 13350
BGC0001831.1 |  | 0.52 | Polyketide | alkylpyrone-407, alkylpyrone-393 | Myxococcus xanthus DK 1622
BGC0001475.1 |  | 0.48 | Polyketide | aspterric acid | Aspergillus terreus NIH2624
BGC0001928.1 |  | 0.47 | Other | (2R,3S,4S)-5-fluoro-2,3,4-trihydroxypentanoic acid | Streptomyces sp. MA37
BGC0001647.1 |  | 0.40 | Polyketide | lagunapyrone A, lagunapyrone B, lagunapyrone C | Streptomyces sp. MP131-18
BGC0001289.1 |  | 0.39 | RiPP | penisin | Paenibacillus ehimensis
BGC0001686.1 |  | 0.37 | NRP | N-octanoyl-Met-Phe-H | Clostridium sp. CAG:567
BGC0001964.1 |  | 0.34 | Polyketide | alkylpyrone-407, alkylpyrone-393 | Cystobacterineae bacterium
BGC0001663.1 |  | 0.32 | Polyketide | merocyclophane C, merocyclophane D | Nostoc sp. UIC 10110
BGC0000284.1 |  | 0.30 | Polyketide | phenolic lipids | Azotobacter vinelandii DJ

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.

No matches found.

Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
NZ_CP014842.1 - Region 6 - terpene
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 2,094,581 - 2,116,470 nt. (total: 21,890 nt) Show pHMM detection rules used
terpene: (Terpene_synth or Terpene_synth_C or phytoene_synt or Lycopene_cycl or terpene_cyclase or NapT7 or fung_ggpps or fung_ggpps2 or trichodiene_synth or TRI5)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
MIBiG comparison
KnownClusterBlast
Pfam domains
TIGRFAM domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | terpene | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001120.1 |  | 0.16 | NRP, Polyketide | burkholderic acid | Burkholderia thailandensis E264
BGC0001925.1 |  | 0.15 | Alkaloid | altemicidin, SB-203207, SB-203208 | Streptomyces sp.
BGC0001535.1 |  | 0.14 | Other | branched-chain fatty acids | Streptomyces filamentosus
BGC0002006.1 |  | 0.11 | RiPP | albusnodin | Streptomyces albus
BGC0000313.1 |  | 0.11 | NRP | beauvericin | Beauveria bassiana
BGC0001575.1 |  | 0.10 | NRP | dipeptide aldehydes | Ruminococcus sp. 5_1_39BFAA
BGC0000663.1 |  | 0.09 | Terpene | hopene | Streptomyces coelicolor A3(2)
BGC0001739.1 |  | 0.09 | Other | phosphonoacetic Acid | Streptomyces sp. NRRL F-525
BGC0001338.1 |  | 0.08 | Polyketide | citrinin | Monascus ruber
BGC0000154.1 |  | 0.07 | Polyketide | stipitatic acid | Talaromyces stipitatus ATCC 10500

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001120.1 |  | 0.47 | NRP, Polyketide | burkholderic acid | Burkholderia thailandensis E264
BGC0001925.1 |  | 0.45 | Alkaloid | altemicidin, SB-203207, SB-203208 | Streptomyces sp.
BGC0001535.1 |  | 0.43 | Other | branched-chain fatty acids | Streptomyces filamentosus
BGC0002006.1 |  | 0.39 | RiPP | albusnodin | Streptomyces albus
BGC0000313.1 |  | 0.38 | NRP | beauvericin | Beauveria bassiana
BGC0001575.1 |  | 0.36 | NRP | dipeptide aldehydes | Ruminococcus sp. 5_1_39BFAA
BGC0000663.1 |  | 0.34 | Terpene | hopene | Streptomyces coelicolor A3(2)
BGC0001739.1 |  | 0.32 | Other | phosphonoacetic Acid | Streptomyces sp. NRRL F-525
BGC0001338.1 |  | 0.30 | Polyketide | citrinin | Monascus ruber
BGC0000154.1 |  | 0.30 | Polyketide | stipitatic acid | Talaromyces stipitatus ATCC 10500

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.

No matches found.

Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
NZ_CP014842.1 - Region 7 - betalactone
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 2,212,862 - 2,241,376 nt. (total: 28,515 nt) Show pHMM detection rules used
betalactone: (HMGL-like and AMP-binding)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
MIBiG comparison
KnownClusterBlast
Pfam domains
TIGRFAM domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | betalactone | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000234.1 |  | 0.21 | Polyketide | jadomycin | Streptomyces venezuelae ATCC 10712
BGC0000259.1 |  | 0.20 | Polyketide | prodigiosin | Serratia marcescens
BGC0000258.1 |  | 0.19 | Polyketide | prodigiosin | Serratia sp.
BGC0000260.1 |  | 0.19 | Polyketide | prodigiosin | Hahella chejuensis KCTC 2396
BGC0001897.1 |  | 0.18 | Polyketide | cepacin A | Burkholderia ambifaria IOP40-10
BGC0001103.1 |  | 0.18 | NRP, Polyketide | mycosubtilin | Bacillus subtilis subsp. spizizenii ATCC 6633
BGC0001983.1 |  | 0.16 | Other | triacsins | Kitasatospora aureofaciens
BGC0001343.1 |  | 0.16 | Polyketide | aurachin A, aurachin D | Stigmatella aurantiaca Sg a15
BGC0000842.1 |  | 0.16 | Other (Non-NRP beta-lactam) | carbapenem MM4550 | Streptomyces argenteolus
BGC0000706.1 |  | 0.16 | Saccharide | kanamycin | Streptomyces kanamyceticus

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000234.1 |  | 0.54 | Polyketide | jadomycin | Streptomyces venezuelae ATCC 10712
BGC0000259.1 |  | 0.53 | Polyketide | prodigiosin | Serratia marcescens
BGC0000258.1 |  | 0.52 | Polyketide | prodigiosin | Serratia sp.
BGC0000260.1 |  | 0.51 | Polyketide | prodigiosin | Hahella chejuensis KCTC 2396
BGC0001897.1 |  | 0.50 | Polyketide | cepacin A | Burkholderia ambifaria IOP40-10
BGC0001103.1 |  | 0.50 | NRP, Polyketide | mycosubtilin | Bacillus subtilis subsp. spizizenii ATCC 6633
BGC0001983.1 |  | 0.47 | Other | triacsins | Kitasatospora aureofaciens
BGC0001343.1 |  | 0.47 | Polyketide | aurachin A, aurachin D | Stigmatella aurantiaca Sg a15
BGC0000842.1 |  | 0.46 | Other (Non-NRP beta-lactam) | carbapenem MM4550 | Streptomyces argenteolus
BGC0000706.1 |  | 0.46 | Saccharide | kanamycin | Streptomyces kanamyceticus

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.
Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
NZ_CP014842.1 - Region 8 - siderophore
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 3,032,453 - 3,047,919 nt. (total: 15,467 nt) Show pHMM detection rules used
siderophore: IucA_IucC

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
MIBiG comparison
KnownClusterBlast
Pfam domains
TIGRFAM domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | siderophore | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000942.1 |  | 0.31 | Other | petrobactin | Bacillus anthracis str. Ames
BGC0001499.1 |  | 0.29 | Other | aerobactin | Pantoea ananatis
BGC0001478.1 |  | 0.27 | Other | desferrioxamine E | Streptomyces sp. ID38640
BGC0000852.1 |  | 0.25 | Other | ectoine | Sporosarcina pasteurii
BGC0000941.1 |  | 0.25 | Other | desferrioxamin B | Streptomyces griseus subsp. griseus NBRC 13350
BGC0001572.1 |  | 0.25 | Other | desferrioxamine E | Pantoea agglomerans
BGC0000858.1 |  | 0.25 | Other | ectoine | Methylobacter marinus
BGC0000853.1 |  | 0.25 | Other | ectoine | Streptomyces anulatus
BGC0000855.1 |  | 0.25 | Other | ectoine | Methylomicrobium kenyense
BGC0000859.1 |  | 0.25 | Other | ectoine | Methylomicrobium alcaliphilum

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000942.1 |  | 0.64 | Other | petrobactin | Bacillus anthracis str. Ames
BGC0001499.1 |  | 0.63 | Other | aerobactin | Pantoea ananatis
BGC0001478.1 |  | 0.61 | Other | desferrioxamine E | Streptomyces sp. ID38640
BGC0000852.1 |  | 0.59 | Other | ectoine | Sporosarcina pasteurii
BGC0000941.1 |  | 0.59 | Other | desferrioxamin B | Streptomyces griseus subsp. griseus NBRC 13350
BGC0001572.1 |  | 0.59 | Other | desferrioxamine E | Pantoea agglomerans
BGC0000858.1 |  | 0.58 | Other | ectoine | Methylobacter marinus
BGC0000853.1 |  | 0.58 | Other | ectoine | Streptomyces anulatus
BGC0000855.1 |  | 0.58 | Other | ectoine | Methylomicrobium kenyense
BGC0000859.1 |  | 0.58 | Other | ectoine | Methylomicrobium alcaliphilum

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.

No matches found.

Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
NZ_CP014842.1 - Region 9 - RiPP-like,thiopeptide
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 3,169,947 - 3,211,238 nt. (total: 41,292 nt) Show pHMM detection rules used
thiopeptide: ((YcaO or TIGR03882) and ((thio_amide and (PF06968 or PF04055 or PF07366)) or Lant_dehydr_C or Lant_dehydr_N or PF07366 or PF06968 or PF04055) or thiostrepton)
RiPP-like: (strepbact or Antimicrobial14 or Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or Lactococcin or Antimicrobial17 or Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or TIGR03975 or DUF692 or TIGR01193)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
MIBiG comparison
KnownClusterBlast
Thiopeptides
Pfam domains
TIGRFAM domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | thiopeptide | RiPP-like | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | --- | ---
BGC0000607.1 |  |  | 0.43 | RiPP | micrococcin P1 | Macrococcus caseolyticus
BGC0000571.1 |  |  | 0.32 | RiPP | burhizin | Paraburkholderia rhizoxinica HKI 454
BGC0000554.1 |  |  | 0.32 | RiPP | SRO15-3108 | Streptomyces filamentosus NRRL 15998
BGC0000617.1 |  |  | 0.32 | RiPP | coagulin | Bacillus coagulans
BGC0001146.1 |  |  | 0.31 | RiPP | cyclothiazomycin C | Streptomyces sp. NRRL WC-3908
BGC0001120.1 |  |  | 0.31 | NRP, Polyketide | burkholderic acid | Burkholderia thailandensis E264
BGC0001928.1 |  |  | 0.30 | Other | (2R,3S,4S)-5-fluoro-2,3,4-trihydroxypentanoic acid | Streptomyces sp. MA37
BGC0000517.1 |  |  | 0.28 | RiPP | haloduracin β, haloduracin α | Bacillus halodurans C-125
BGC0000624.1 |  |  | 0.28 | RiPP | salivaricin CRL1328 α peptide, salivaricin CRL1328 β peptide | Lactobacillus salivarius
BGC0001889.1 |  |  | 0.28 | RiPP | fusilassin | Thermobifida fusca YX

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000607.1 |  | 0.59 | RiPP | micrococcin P1 | Macrococcus caseolyticus
BGC0000568.1 |  | 0.53 | RiPP | microcin B17 | Escherichia coli
BGC0000938.1 |  | 0.50 | Other (Aminocoumarin) | fosfomycin | Streptomyces fradiae
BGC0000602.1 |  | 0.49 | RiPP | subtilosin A | Bacillus subtilis subsp. spizizenii ATCC 6633
BGC0001120.1 |  | 0.48 | NRP, Polyketide | burkholderic acid | Burkholderia thailandensis E264
BGC0000599.1 |  | 0.48 | RiPP | thuricin CD α, thuricin CD β | Bacillus thuringiensis
BGC0000483.1 |  | 0.48 | RiPP | aeruginosamide B, aeruginosamide C | Microcystis aeruginosa PCC 9432
BGC0001146.1 |  | 0.48 | RiPP | cyclothiazomycin C | Streptomyces sp. NRRL WC-3908
BGC0000554.1 |  | 0.48 | RiPP | SRO15-3108 | Streptomyces filamentosus NRRL 15998
BGC0000523.1 |  | 0.47 | RiPP | lactocin S | Lactobacillus sakei

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.
Thiopeptide predictions
Lists the possible core peptides for each biosynthetic enzyme, including the predicted class. Each core peptide shows the leader and core peptide sequences, separated by a dash. Predicted tail sequences are also shown.
No core peptides found.
Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
Thiopeptides
Core peptide predictions
Lists the possible core peptides in the region. Each core peptide lists its possible molecular weights and the scores for cleavage site prediction and RODEO. If relevant, other features, such as macrocycle and amidation, will also be listed.
No core peptides found.
NZ_CP014842.1 - Region 10 - NRPS
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 3,810,402 - 3,875,851 nt. (total: 65,450 nt) Show pHMM detection rules used
NRPS: cds(Condensation and (AMP-binding or A-OX))

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
NRPS/PKS domains
MIBiG comparison
KnownClusterBlast
NRPS/PKS modules
Pfam domains
TIGRFAM domains
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
A glossary is available here.
Selected features only
Show module domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | NRPS | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000381.1 |  | 1.00 | NRP | lichenysin | Bacillus licheniformis DSM 13 = ATCC 14580
BGC0000389.1 |  | 0.43 | NRP | massetolide A | Pseudomonas fluorescens SS101
BGC0000426.1 |  | 0.35 | NRP | sevadicin | Paenibacillus larvae
BGC0001767.1 |  | 0.33 | NRP | salinichelins | Salinispora pacifica CNY331
BGC0001833.1 |  | 0.33 | NRP | icosalide A, icosalide B | Burkholderia gladioli
BGC0001615.1 |  | 0.33 | NRP | hexose-palythine-serine, hexose-shinorine | Heteroscytonema crispum UCFS10
BGC0000417.1 |  | 0.33 | NRP | rhodochelin | Rhodococcus jostii RHA1
BGC0001128.1 |  | 0.32 | NRP | luminmide | Photorhabdus laumondii subsp. laumondii TTO1
BGC0001796.1 |  | 0.32 | NRP | tauramamide | Brevibacillus laterosporus DSM 25
BGC0001844.1 |  | 0.32 | NRP | holrhizin | Paraburkholderia rhizoxinica HKI 454

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000381.1 |  | 1.00 | NRP | lichenysin | Bacillus licheniformis DSM 13 = ATCC 14580
BGC0000389.1 |  | 0.74 | NRP | massetolide A | Pseudomonas fluorescens SS101
BGC0000426.1 |  | 0.68 | NRP | sevadicin | Paenibacillus larvae
BGC0001767.1 |  | 0.66 | NRP | salinichelins | Salinispora pacifica CNY331
BGC0001833.1 |  | 0.66 | NRP | icosalide A, icosalide B | Burkholderia gladioli
BGC0001615.1 |  | 0.66 | NRP | hexose-palythine-serine, hexose-shinorine | Heteroscytonema crispum UCFS10
BGC0000417.1 |  | 0.66 | NRP | rhodochelin | Rhodococcus jostii RHA1
BGC0001128.1 |  | 0.66 | NRP | luminmide | Photorhabdus laumondii subsp. laumondii TTO1
BGC0001796.1 |  | 0.65 | NRP | tauramamide | Brevibacillus laterosporus DSM 25
BGC0001844.1 |  | 0.65 | NRP | holrhizin | Paraburkholderia rhizoxinica HKI 454

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.
Module view
Shows module structures for each candidate in NRPS- and PKS regions. Genes are shown in predicted order, and are only present when containing at least one complete module. A domain glossary is available here.
Legend
Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
NRPS/PKS products
NRPS/PKS monomers
Predicted core structure(s)
Shows estimated product structure and polymer for each candidate cluster in the region. To show the product, click on the expander or the candidate cluster feature drawn in the overview.
For candidate cluster 10, location 3810401 - 3875851:
Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:
  (gln - leu - D-leu) + (val - asp - D-leu) + (ile)

Direct lookup in NORINE database: strict or relaxed
Link to NORINE database query form
NRPS/PKS monomer predictions
Shows the predicted monomers for each adynelation domain and acyltransferase within genes. Each gene prediction can be expanded to view detailed predictions of each domain. Each prediction can be expanded to view the predictions by tool (and, for some tools, further expanded for extra details).

ctg1_3864: ile
  Search NORINE for peptide: strict or relaxed
  AMP-binding (472..870): ile
  NRPSPredictor2: ile
  SVM prediction details:
    Predicted physicochemical class:
      hydrophobic-aliphatic
    Large clusters prediction:
      gly, ala, val, leu, ile, abu, iva
    Small clusters prediction:
      val, leu, ile, abu, iva
    Single AA prediction:
      ile
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DGFFLGVVFK
    Nearest Stachelhaus code:
      ile
    Stachelhaus code match:
      100% (strong)
ctg1_3865: val - asp - leu
  Search NORINE for peptide: strict or relaxed
  AMP-binding (470..862): val
  NRPSPredictor2: val
  SVM prediction details:
    Predicted physicochemical class:
      hydrophobic-aliphatic
    Large clusters prediction:
      gly, ala, val, leu, ile, abu, iva
    Small clusters prediction:
      val, leu, ile, abu, iva
    Single AA prediction:
      val
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DAFWIGGTFK
    Nearest Stachelhaus code:
      val
    Stachelhaus code match:
      100% (strong)
  AMP-binding (1502..1905): asp
  NRPSPredictor2: asp
  SVM prediction details:
    Predicted physicochemical class:
      hydrophilic
    Large clusters prediction:
      asp, asn, glu, gln, aad
    Small clusters prediction:
      asp, asn
    Single AA prediction:
      asp
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DLTKVGHIGK
    Nearest Stachelhaus code:
      asp
    Stachelhaus code match:
      100% (strong)
  AMP-binding (2547..2936): leu
  NRPSPredictor2: leu
  SVM prediction details:
    Predicted physicochemical class:
      hydrophobic-aliphatic
    Large clusters prediction:
      gly, ala, val, leu, ile, abu, iva
    Small clusters prediction:
      val, leu, ile, abu, iva
    Single AA prediction:
      leu
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DAWFLGNVVK
    Nearest Stachelhaus code:
      leu
    Stachelhaus code match:
      100% (strong)
ctg1_3866: gln - leu - leu
  Search NORINE for peptide: strict or relaxed
  AMP-binding (465..868): gln
  NRPSPredictor2: gln
  SVM prediction details:
    Predicted physicochemical class:
      hydrophilic
    Large clusters prediction:
      asp, asn, glu, gln, aad
    Small clusters prediction:
      glu, gln
    Single AA prediction:
      gln
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DAQDLGVVDK
    Nearest Stachelhaus code:
      gln
    Stachelhaus code match:
      100% (strong)
  AMP-binding (1511..1909): leu
  NRPSPredictor2: leu
  SVM prediction details:
    Predicted physicochemical class:
      hydrophobic-aliphatic
    Large clusters prediction:
      gly, ala, val, leu, ile, abu, iva
    Small clusters prediction:
      val, leu, ile, abu, iva
    Single AA prediction:
      leu
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DAFMLGMVFK
    Nearest Stachelhaus code:
      leu
    Stachelhaus code match:
      100% (strong)
  AMP-binding (2550..2939): leu
  NRPSPredictor2: leu
  SVM prediction details:
    Predicted physicochemical class:
      hydrophobic-aliphatic
    Large clusters prediction:
      gly, ala, val, leu, ile, abu, iva
    Small clusters prediction:
      val, leu, ile, abu, iva
    Single AA prediction:
      leu
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DAWFLGNVVK
    Nearest Stachelhaus code:
      leu
    Stachelhaus code match:
      100% (strong)