LOCUS       NZ_CP017060.1           9733 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  NZ_CP017060.1 Bacillus cereus strain FORC_047 chromosome, complete
            genome.
ACCESSION   NZ_CP017060
VERSION     NZ_CP017060.1
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 6.1.1
            Run date     :: 2024-03-14 13:05:24
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 2501695
            Orig. end    :: 2511428
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     CDS             1..1449
                     /NRPS_PKS="Domain: Aminotran_1_2 (145-469). E-value:
                     6.6e-30. Score: 96.2. Matches aSDomain:
                     nrpspksdomains_ctg1_2401_Aminotran_1_2.1"
                     /NRPS_PKS="type: other"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1019:aminotransferase (Score: 327.1; E-value:
                     2.5e-99)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg1_2401"
                     /transl_table=11
                     /translation="LFKDFKVVKDRPVYIQLKDYLKKMIMKGHLLGDQKIPSTRELSEL
                     LSVSRNTVLAAYADLEQEGLIYAVKGKGNFVAKVDISNTSSVEIDWKNKLNTVTALADE
                     LDLMKHGVRWEKGMIVFNSIAPDEKLFDVENFKRAFLTRMSIEGDIVLNYGYAKGYRPL
                     MNYLLHYMEMKGVDISNKDILITNGFTEGLDIVLSSLSKKSGRVICENPTHHAALKLFR
                     LHGLEVHGIDMHEDGIDTNEVEKSLREKDFDFAYLIPSYHNPTGIVTSSEKRTELMRLF
                     SKYKIPIIEDGFNEELRYSGSHLAPLLTFAGAGNNVIYISSFSKVLFPGLRVGWIIADK
                     ELIHYLESVKRARTIHTSTLDQAVLFQYLHEGYFEKYLKKARSVYKKKYELAVGACNQY
                     IPFKRMTGDGGLHLFIELEEHMNARTLLQKCYEKGVTFSPGDVFYSDGEGANTFRLGFS
                     RLKEEEIVRGIKIIGDTLKNEIWS"
     protocluster    1..9733
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[2506271:2506601](+)"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193)"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      4577..4906
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193)"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
     cand_cluster    1..9733
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193)"
                     /kind="single"
                     /product="RiPP-like"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..9733
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="RiPP-like"
                     /region_number="7"
                     /rules="(strepbact or Antimicrobial14 or Bacteriocin_IId or
                     BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or
                     Lactococcin or Antimicrobial17 or Lactococcin_972 or
                     Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or
                     TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or
                     TIGR03975 or DUF692 or TIGR01193)"
                     /tool="antismash"
     PFAM_domain     43..228
                     /aSDomain="GntR"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00392.23"
                     /description="Bacterial regulatory proteins, gntR family"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_2401_0232"
                     /evalue="1.10E-13"
                     /label="ctg1_2401"
                     /locus_tag="ctg1_2401"
                     /protein_end="76"
                     /protein_start="14"
                     /score="50.7"
                     /tool="antismash"
                     /translation="IQLKDYLKKMIMKGHLLGDQKIPSTRELSELLSVSRNTVLAAYAD
                     LEQEGLIYAVKGKGNFV"
     aSDomain        436..1407
                     /aSDomain="Aminotran_1_2"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg1_2401_Aminotran_1_2.1"
                     /evalue="6.60E-30"
                     /label="ctg1_2401_Aminotran_1_2.1"
                     /locus_tag="ctg1_2401"
                     /protein_end="469"
                     /protein_start="145"
                     /score="96.2"
                     /tool="antismash"
                     /translation="IEGDIVLNYGYAKGYRPLMNYLLHYMEMKGVDISNKDILITNGFT
                     EGLDIVLSSLSKKSGRVICENPTHHAALKLFRLHGLEVHGIDMHEDGIDTNEVEKSLRE
                     KDFDFAYLIPSYHNPTGIVTSSEKRTELMRLFSKYKIPIIEDGFNEELRYSGSHLAPLL
                     TFAGAGNNVIYISSFSKVLFPGLRVGWIIADKELIHYLESVKRARTIHTSTLDQAVLFQ
                     YLHEGYFEKYLKKARSVYKKKYELAVGACNQYIPFKRMTGDGGLHLFIELEEHMNARTL
                     LQKCYEKGVTFSPGDVFYSDGEGANTFRLGFSRLKEEEIVRGI"
     PFAM_domain     436..1407
                     /aSDomain="Aminotran_1_2"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00155.23"
                     /description="Aminotransferase class I and II"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_2401_0233"
                     /evalue="2.50E-27"
                     /label="ctg1_2401"
                     /locus_tag="ctg1_2401"
                     /protein_end="469"
                     /protein_start="145"
                     /score="96.1"
                     /tool="antismash"
                     /translation="IEGDIVLNYGYAKGYRPLMNYLLHYMEMKGVDISNKDILITNGFT
                     EGLDIVLSSLSKKSGRVICENPTHHAALKLFRLHGLEVHGIDMHEDGIDTNEVEKSLRE
                     KDFDFAYLIPSYHNPTGIVTSSEKRTELMRLFSKYKIPIIEDGFNEELRYSGSHLAPLL
                     TFAGAGNNVIYISSFSKVLFPGLRVGWIIADKELIHYLESVKRARTIHTSTLDQAVLFQ
                     YLHEGYFEKYLKKARSVYKKKYELAVGACNQYIPFKRMTGDGGLHLFIELEEHMNARTL
                     LQKCYEKGVTFSPGDVFYSDGEGANTFRLGFSRLKEEEIVRGI"
     CDS             1454..2368
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) RimK"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ATP-grasp"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg1_2402"
                     /sec_met_domain="RimK (E-value: 5e-09, bitscore: 34.3,
                     seeds: 4, tool: rule-based-clusters)"
                     /sec_met_domain="ATP-grasp (E-value: 1.2e-05, bitscore:
                     23.2, seeds: 20, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKIGVIMGGVSSEKQVSIMTGNEMIAHLDKNKYEIVPITLNEKMD
                     LIEKAKDIDFALLALHGKYGEDGTVQGTLESLGIPYSGSNMLSSSICMDKNISKKILRY
                     EGVETPDWIELTKMEDLNLDELDKLGFPLVVKPNSGGSSVGVKIVYNKNELISMLETVF
                     EWDSEVVIEKYIKGDEITCSILDGKQLPIVSIRHAAEFFDYNAKYDDTSTVEEVIELPA
                     EINERVNKASLTCYKALKCSVYARVDMMVKDGIPYVMEINTLPGMTQSSLLPKSAEAAG
                     ISYSKLLDMIIETSLKVRNEEGF"
     PFAM_domain     1457..1705
                     /aSDomain="Dala_Dala_lig_N"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF01820.23"
                     /description="D-ala D-ala ligase N-terminus"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_2402_0234"
                     /evalue="3.00E-21"
                     /label="ctg1_2402"
                     /locus_tag="ctg1_2402"
                     /protein_end="84"
                     /protein_start="1"
                     /score="76.0"
                     /tool="antismash"
                     /translation="KIGVIMGGVSSEKQVSIMTGNEMIAHLDKNKYEIVPITLNEKMDL
                     IEKAKDIDFALLALHGKYGEDGTVQGTLESLGIPYSGS"
     aSDomain        1457..2338
                     /aSDomain="TIGR01205"
                     /aSTool="tigrfam"
                     /description="D_ala_D_alaTIGR: D-alanine--D-alanine ligase"
                     /detection="hmmscan"
                     /domain_id="TIGRFam_ctg1_2402_0053"
                     /evalue="5.50E-89"
                     /identifier="TIGR01205"
                     /label="ctg1_2402"
                     /locus_tag="ctg1_2402"
                     /protein_end="295"
                     /protein_start="1"
                     /score="296.2"
                     /tool="antismash"
                     /translation="KIGVIMGGVSSEKQVSIMTGNEMIAHLDKNKYEIVPITLNEKMDL
                     IEKAKDIDFALLALHGKYGEDGTVQGTLESLGIPYSGSNMLSSSICMDKNISKKILRYE
                     GVETPDWIELTKMEDLNLDELDKLGFPLVVKPNSGGSSVGVKIVYNKNELISMLETVFE
                     WDSEVVIEKYIKGDEITCSILDGKQLPIVSIRHAAEFFDYNAKYDDTSTVEEVIELPAE
                     INERVNKASLTCYKALKCSVYARVDMMVKDGIPYVMEINTLPGMTQSSLLPKSAEAAGI
                     SYSKLLDMIIETS"
     PFAM_domain     1760..2332
                     /aSDomain="Dala_Dala_lig_C"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF07478.15"
                     /description="D-ala D-ala ligase C-terminus"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_2402_0235"
                     /evalue="1.30E-52"
                     /label="ctg1_2402"
                     /locus_tag="ctg1_2402"
                     /protein_end="293"
                     /protein_start="102"
                     /score="178.4"
                     /tool="antismash"
                     /translation="RYEGVETPDWIELTKMEDLNLDELDKLGFPLVVKPNSGGSSVGVK
                     IVYNKNELISMLETVFEWDSEVVIEKYIKGDEITCSILDGKQLPIVSIRHAAEFFDYNA
                     KYDDTSTVEEVIELPAEINERVNKASLTCYKALKCSVYARVDMMVKDGIPYVMEINTLP
                     GMTQSSLLPKSAEAAGISYSKLLDMIIE"
     CDS             2675..3364
                     /locus_tag="ctg1_2403"
                     /transl_table=11
                     /translation="MTFSQSLRKEVDSIWEASFNHPFVKKLGEGTLDLASFRYYVLQDS
                     YYLSHFARVQTLGAAKALELETTARMAHHAQNTYEAELSLHENFAKKLGITKEEKDNFI
                     PAPTAYAYTSHMYRAAYEGHLGDIIAAILPCYWLYYEIGERLKECQPEEPIYNEWISAY
                     GSDWFRTLVEEQITRLDTIAEKVTEVDRKRMKQHFIISSQYEYSFWEMAYTLEKWPVDT
                     DVKDVIG"
     PFAM_domain     2699..3316
                     /aSDomain="TENA_THI-4"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF03070.18"
                     /description="TENA/THI-4/PQQC family"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_2403_0236"
                     /evalue="2.90E-57"
                     /label="ctg1_2403"
                     /locus_tag="ctg1_2403"
                     /protein_end="214"
                     /protein_start="8"
                     /score="194.0"
                     /tool="antismash"
                     /translation="KEVDSIWEASFNHPFVKKLGEGTLDLASFRYYVLQDSYYLSHFAR
                     VQTLGAAKALELETTARMAHHAQNTYEAELSLHENFAKKLGITKEEKDNFIPAPTAYAY
                     TSHMYRAAYEGHLGDIIAAILPCYWLYYEIGERLKECQPEEPIYNEWISAYGSDWFRTL
                     VEEQITRLDTIAEKVTEVDRKRMKQHFIISSQYEYSFWEMAYT"
     aSDomain        2705..3316
                     /aSDomain="TIGR04306"
                     /aSTool="tigrfam"
                     /description="salvage_TenA: thiaminase II"
                     /detection="hmmscan"
                     /domain_id="TIGRFam_ctg1_2403_0054"
                     /evalue="1.60E-75"
                     /identifier="TIGR04306"
                     /label="ctg1_2403"
                     /locus_tag="ctg1_2403"
                     /protein_end="214"
                     /protein_start="10"
                     /score="251.3"
                     /tool="antismash"
                     /translation="VDSIWEASFNHPFVKKLGEGTLDLASFRYYVLQDSYYLSHFARVQ
                     TLGAAKALELETTARMAHHAQNTYEAELSLHENFAKKLGITKEEKDNFIPAPTAYAYTS
                     HMYRAAYEGHLGDIIAAILPCYWLYYEIGERLKECQPEEPIYNEWISAYGSDWFRTLVE
                     EQITRLDTIAEKVTEVDRKRMKQHFIISSQYEYSFWEMAYT"
     CDS             3765..4028
                     /locus_tag="ctg1_2404"
                     /transl_table=11
                     /translation="MNFERCYMFTNKKLIRFGLSLFVFLGIINFTISYFQTYLETAADI
                     KWVIPEIWKTILLDVPQGILVLLGAIALYDFTKEVSQKDASI"
     PFAM_domain     3786..4001
                     /aSDomain="DUF3937"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF13073.8"
                     /description="Protein of unknown function (DUF3937)"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_2404_0237"
                     /evalue="1.20E-51"
                     /label="ctg1_2404"
                     /locus_tag="ctg1_2404"
                     /protein_end="79"
                     /protein_start="7"
                     /score="172.8"
                     /tool="antismash"
                     /translation="MFTNKKLIRFGLSLFVFLGIINFTISYFQTYLETAADIKWVIPEI
                     WKTILLDVPQGILVLLGAIALYDFTKE"
     aSDomain        4577..4849
                     /aSDomain="TIGR03601"
                     /aSTool="tigrfam"
                     /description="B_an_ocin: bacteriocin,
                     heterocycloanthracin/sonorensin family"
                     /detection="hmmscan"
                     /domain_id="TIGRFam_ctg1_2405_0055"
                     /evalue="1.10E-40"
                     /identifier="TIGR03601"
                     /label="ctg1_2405"
                     /locus_tag="ctg1_2405"
                     /protein_end="91"
                     /protein_start="0"
                     /score="136.2"
                     /tool="antismash"
                     /translation="MNQFQQELQALSLNDYRSGNIVYWDQQNQYPYYYIEDAARRCGGC
                     GRCGGCGGGRCGGFRCGGFRCIGCFGCFGCGGCGGCGGCGGCSNCF"
     CDS             4577..4906
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: TIGR03601"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg1_2405"
                     /sec_met_domain="TIGR03601 (E-value: 8.2e-39, bitscore:
                     130.2, seeds: 6, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNQFQQELQALSLNDYRSGNIVYWDQQNQYPYYYIEDAARRCGGC
                     GRCGGCGGGRCGGFRCGGFRCIGCFGCFGCGGCGGCGGCGGCSNCFDGFSGTTDTTGTI
                     ITYEY"
     CDS             5390..5875
                     /locus_tag="ctg1_2406"
                     /transl_table=11
                     /translation="MNMIELKSIIHSYKLKRKIAKDLYGKRDELTLLLNEFNKMKCTVT
                     SEKKKNNILSRLQLIYQNMKLDKQYPLSVAFDSKLLERLEKEPLHTIEDGVTCLHLMLD
                     VNYEKIKQYGSSTSRSFVPLSQSSICLADCICLTGVVVGLLGAISFGGLLLSICSIT"
     CDS             6187..6888
                     /locus_tag="ctg1_2407"
                     /transl_table=11
                     /translation="MKKLRLLTFENIVEPLLNEKVSFIYFPIEWLDIVEIHYKTFLLTS
                     KLKRLNERLYDMFSDILFIQHNPYVLNENTPWIVSKEPIRQEQLDYIFQSWYEIIHDWK
                     PNRLVEPPKYEWQSDLISNLPVLHDIETYSKWVPALISHIFCERPIYLENTNEEEIYFS
                     PLRSQNICEAMSGPIKDEKTQDFFSYVYRFECITRGGENAPLLNISIGIRRFYQEYKMI
                     GQTNLDMTTFV"
     PFAM_domain     6235..6834
                     /aSDomain="pPIWI_RE_X"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF13111.8"
                     /description="pPIWI_RE module N-terminal domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_2407_0238"
                     /evalue="2.60E-17"
                     /label="ctg1_2407"
                     /locus_tag="ctg1_2407"
                     /protein_end="216"
                     /protein_start="16"
                     /score="63.2"
                     /tool="antismash"
                     /translation="LNEKVSFIYFPIEWLDIVEIHYKTFLLTSKLKRLNERLYDMFSDI
                     LFIQHNPYVLNENTPWIVSKEPIRQEQLDYIFQSWYEIIHDWKPNRLVEPPKYEWQSDL
                     ISNLPVLHDIETYSKWVPALISHIFCERPIYLENTNEEEIYFSPLRSQNICEAMSGPIK
                     DEKTQDFFSYVYRFECITRGGENAPLLNISIGIRRFY"
     CDS             complement(6927..8036)
                     /gene_functions="other (smcogs) SMCOG1077:phage integrase
                     family protein (Score: 176.5; E-value: 1.6e-53)"
                     /gene_kind="other"
                     /locus_tag="ctg1_2408"
                     /transl_table=11
                     /translation="VKGHIRKRGNKYCIVIDIGPDPETGKRRQKWFSGYKTKKEAQADV
                     AKKITELNEGTFIEPSKVTLKDYLNHWLEIKSMSIEKSTFAGYRAFINLHVLPSIGMVA
                     LHKLNVMHIQKCYKTAIDKGIANNSILLMHRILKSALNLAIKQNIISRNPADFAEIPKK
                     EKTPIQTWTEEEVKKFLAHSQESRYHIGYLLAITTGMRLGEVLGLRWQDIDFEKHTVTI
                     NQTSGHDNKIKKTAKTNSSKRTIPVPNETIAALKKHKILINKEKLKFGSAYLDQDLINC
                     NEFGRIIKRAHFRKSFIRTTHKVGIKEIKFHDLRHTHATLLLKQGVNPKIISERLGHTD
                     ISMTLSVYSHVLPNMQEEAVKNFGKSIFG"
     PFAM_domain     complement(6981..7523)
                     /aSDomain="Phage_integrase"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00589.24"
                     /description="Phage integrase family"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_2408_0241"
                     /evalue="8.20E-31"
                     /label="ctg1_2408"
                     /locus_tag="ctg1_2408"
                     /protein_end="352"
                     /protein_start="171"
                     /score="107.2"
                     /tool="antismash"
                     /translation="TEEEVKKFLAHSQESRYHIGYLLAITTGMRLGEVLGLRWQDIDFE
                     KHTVTINQTSGHDNKIKKTAKTNSSKRTIPVPNETIAALKKHKILINKEKLKFGSAYLD
                     QDLINCNEFGRIIKRAHFRKSFIRTTHKVGIKEIKFHDLRHTHATLLLKQGVNPKIISE
                     RLGHTDISMTLSVYSHVL"
     PFAM_domain     complement(7683..7847)
                     /aSDomain="Phage_int_SAM_3"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF14659.8"
                     /description="Phage integrase, N-terminal SAM-like domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_2408_0240"
                     /evalue="2.60E-09"
                     /label="ctg1_2408"
                     /locus_tag="ctg1_2408"
                     /protein_end="118"
                     /protein_start="63"
                     /score="37.2"
                     /tool="antismash"
                     /translation="TLKDYLNHWLEIKSMSIEKSTFAGYRAFINLHVLPSIGMVALHKL
                     NVMHIQKCYK"
     PFAM_domain     complement(7866..8003)
                     /aSDomain="Arm-DNA-bind_4"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF14657.8"
                     /description="Arm DNA-binding domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_2408_0239"
                     /evalue="1.90E-10"
                     /label="ctg1_2408"
                     /locus_tag="ctg1_2408"
                     /protein_end="57"
                     /protein_start="11"
                     /score="40.4"
                     /tool="antismash"
                     /translation="YCIVIDIGPDPETGKRRQKWFSGYKTKKEAQADVAKKITELNEGT
                     F"
     CDS             8582..9733
                     /locus_tag="ctg1_2409"
                     /transl_table=11
                     /translation="MWKALNQIEKELCAAGIRKNKLANYWGVKPSTVTKVFKGNTDMSF
                     GFLSKTVILLNKGIQVQENLLTDYIHITKPKSENLREAMEDLALRGKFNLLINIINSES
                     QSKVAENREFANVYRIIYRRYIGEIDAIQYHEALSLESKSIRTSEMEVLIEILLCQAQY
                     QSGNFTALNERLKSLEIKINKISNRYIRECYKLRYKEAIAVTSLQGGEVIEARHVSMEL
                     LDDLEWDNFFSFPKVNAYLKLGESYIFSANEYEKAKYYLEKTLEVLGDSKINGIERKRK
                     MVQHTLSFLKIHHDKEISSVDVVHPGELAYLRIKQGKRIEARKLLIQLKEKNGRLTDIQ
                     TAYLGLTYEGTKKEELMKRSLLMCQKSGNIFYSNLPKIHLGLI"
ORIGIN
        1 ttgtttaagg attttaaagt tgttaaagat cgtcccgttt atattcaatt aaaagactat
       61 ttgaaaaaga tgattatgaa agggcatttg ctcggggatc aaaaaatccc atcaacaagg
      121 gaactaagtg aattactaag tgtgagtaga aacactgtac tcgctgctta tgcagattta
      181 gagcaagaag gactcattta tgcagttaaa ggaaaaggga actttgttgc gaaggtggat
      241 atatctaaca cttcgtctgt tgaaatagat tggaaaaata aacttaatac agtgaccgca
      301 ttagcggacg aattagattt aatgaaacat ggtgttcgtt gggaaaaggg aatgattgtt
      361 tttaatagta tagccccgga tgagaagcta tttgatgttg aaaatttcaa aagagctttt
      421 cttactcgta tgtccattga aggggacatc gtattgaact acggatatgc aaagggatat
      481 agaccgttaa tgaattattt acttcattac atggaaatga aaggtgtaga catttcgaat
      541 aaagatattc taattacaaa tggatttaca gaaggattgg atattgtact ttcttcttta
      601 tcaaaaaaat ccggtcgtgt catttgtgag aatccaactc accatgctgc acttaagctt
      661 ttccgtttac atggacttga agttcatggg attgatatgc atgaggatgg tattgatacg
      721 aatgaagttg aaaaaagttt gcgtgaaaaa gattttgatt ttgcttattt aattccttct
      781 tatcataatc caaccggtat tgttacgagt tcagagaaaa gaacggaatt gatgaggtta
      841 ttctcaaaat acaagattcc tattatagag gacggattta atgaggaatt acgttattca
      901 ggttcacatt tagctccatt attaactttt gcgggagctg gcaataatgt gatttatatt
      961 agtagctttt caaaggtgct tttccctggt ttacgtgtag gctggattat tgcagataaa
     1021 gagctgattc attatttaga aagcgtaaaa agagcaagaa cgattcacac atctacgcta
     1081 gatcaagctg ttctgtttca atatttacat gagggatatt ttgaaaaata tttaaaaaag
     1141 gcaagatctg tttataagaa aaaatatgag ttagctgtcg gggcatgtaa ccagtacatt
     1201 ccttttaaaa gaatgactgg agatggtgga cttcatttat ttatagagct agaagagcat
     1261 atgaatgccc gcacactttt acaaaagtgt tatgagaaag gcgttacgtt ttcacctgga
     1321 gatgtttttt actctgatgg agaaggagca aacactttcc gattagggtt ttcgcgcttg
     1381 aaagaagaag aaatagttcg gggaattaaa ataattggtg atacattaaa aaatgaaatt
     1441 tggagttgag aaaatgaaaa tcggtgttat tatgggcggg gtatcgtctg aaaaacaagt
     1501 ttcaattatg acggggaatg aaatgattgc tcatttagat aaaaataagt atgaaatagt
     1561 tccaattaca ttaaacgaaa aaatggattt aattgaaaaa gcgaaagaca ttgactttgc
     1621 attgctcgca ttacacggaa aatacggaga agatgggaca gttcaaggaa cactggagag
     1681 tttagggatt ccttatagcg gaagtaatat gttatctagc agtatatgta tggataaaaa
     1741 tatttcgaaa aagattttac gttatgaagg tgtagaaaca ccagattgga ttgaacttac
     1801 aaaaatggag gatctaaatc ttgatgagtt agataagtta ggatttccat tagtggtaaa
     1861 accaaactct ggcggatcga gtgtcggggt gaaaatcgtt tacaataaaa atgaattgat
     1921 ctcaatgcta gaaactgtat tcgaatggga ttctgaagta gtaattgaga agtatataaa
     1981 aggtgatgaa atcacatgtt ctattctgga tggaaaacag ttacctatag tttcaattcg
     2041 acatgcagcc gagttctttg attacaatgc aaaatatgat gatactagta cagttgagga
     2101 agttatcgaa cttccagcag aaattaatga acgtgtaaat aaagcttcac tgacttgtta
     2161 taaagcatta aaatgtagtg tttatgcaag agttgatatg atggtgaagg acggaattcc
     2221 atatgtaatg gaaattaata cattaccagg gatgacacaa tcaagcctat tgcccaaaag
     2281 tgcagaagca gcgggaatta gttatagcaa actattagat atgattattg aaacatcatt
     2341 aaaagttaga aatgaagaag ggttttaagg agattatata actaattctt ttgacagttt
     2401 cacgaagtat gctatgatga atacattata aaaacaaaat atttatccac taggggggcc
     2461 ttttataggc tgagatcaaa tgtgattttg agactcttag tacctgatct ggttaatgcc
     2521 agcgtaggga agtgggaaag acgttgctat ttaatgagta aataaatact gtcaatttca
     2581 ctttctttac gcctgtaaag aaagtttttt tattttacag ctttaataat tgtggataaa
     2641 tacttatatt ttatacatta ttggagggat ttaaatgact ttttcacaat cattacgtaa
     2701 agaagtagat tcaatttggg aagcgagttt taaccatcct tttgtaaaaa aacttggtga
     2761 aggaacatta gatttagcta gttttcgcta ttatgtgctt caagattcat attatttgag
     2821 tcattttgct agagtacaaa ctttaggagc tgcaaaagct cttgaattag agacgacagc
     2881 tcgtatggca catcatgctc aaaatacata tgaggccgag ttatctttac atgagaattt
     2941 tgctaaaaag ctagggataa caaaagaaga aaaagataat tttattcctg cgccaactgc
     3001 atatgcgtat acttcacata tgtatcgtgc tgcgtatgaa gggcatttag gagatatcat
     3061 tgcagcaatt ttaccttgct attggttgta ttatgaaatt ggcgaacgct taaaagagtg
     3121 ccagccggaa gagccaattt ataacgaatg gatttctgct tatggatctg attggttccg
     3181 tacgctagtt gaagaacaaa ttacacgttt agatactatc gctgaaaaag taacagaggt
     3241 agaccgcaaa cgtatgaaac agcattttat tattagcagt caatatgaat attcattttg
     3301 ggaaatggct tatacattag aaaagtggcc agtggataca gacgtaaaag acgtaattgg
     3361 ataaagaata gaaataatgt tatagatagg tatggatcat acctatctat atatttttta
     3421 ttgtcaaatt tgcgtaaagt cattagtgct acggatatgg cgaaataaaa tatcgataat
     3481 ttagcagctc atttacttgt ctacgcatta actggataaa cttctgtcac atttatttta
     3541 caatcaaagg acgtaaatgt tggtggtatg aagttaaata agaaaagaaa cccgagctgt
     3601 tagctgtaac ggagttgttt tttctttgca ggaatttcta aattatcatg gagtgttgtt
     3661 aatacgatat gcaaatatgc atatcgtatt tttttgagtt cttcatgtgt taaaattaga
     3721 tataaagata tggaaatata aagaagcaaa agcaggaata tccaatgaat tttgagaggt
     3781 gttatatgtt tacaaataag aaattaattc gatttggttt atcgttgttt gtatttttag
     3841 ggataattaa ttttacaatc agctatttcc aaacatatct tgaaacagca gcagatatta
     3901 aatgggtaat tccagaaatt tggaaaacta ttttgctaga tgttcctcaa ggtatacttg
     3961 ttcttttagg cgcaattgct ttatatgatt tcacaaaaga ggtatcacaa aaagacgcat
     4021 caatctaagt gtgtcttttt tctattagga atttcataga gagttttgct ggagaaatag
     4081 aatgaaaagc cctaataagg gtttttttct ttgtaggaat tttttatccg tcatagaaac
     4141 cggttacttg gaggtgttat agcgaaaggc atttacagta cagaaaaatc taagcggcag
     4201 acggaaatat ataggatatg gcaacataat tattgagaaa ttaattgaat ttagtaggta
     4261 tgaagatatg acgctagaat tcatattttt taatttttat ttatcccgca ttaacgggct
     4321 gttcgtaaaa gcctgattgg tgagggctaa taatcagcgg gggatgaact ccccccactg
     4381 attaaagttt cactttataa aaatgagccc atagcaaaaa taggtatatg aacaaggtgc
     4441 atcatttagt gataagtcat actttgttgg tgtacgtatt gaacttagtt tatagcgcta
     4501 tttttactta gatgtaacga acagaaatat agggaagcat caatgaggtt gtattttata
     4561 aacggaggtt atgaaaatga atcagtttca acaagaacta caagcgttaa gtcttaatga
     4621 ttaccgatct ggaaatattg tctattggga ccagcaaaat caatatccat attactatat
     4681 tgaagatgct gctcgtcgct gtggcggttg tggtcgttgt ggtggttgtg gtggaggtcg
     4741 ttgtggcgga ttccgttgtg gtggattccg ttgtattggt tgcttcggtt gttttggttg
     4801 cggaggttgc ggaggttgtg gcggctgtgg tggttgctct aactgttttg atggttttag
     4861 tggtactact gatactactg gtactattat aacgtatgaa tattgattgc atttatcctg
     4921 ctatttgccg ggcagtaaga ccctaaaaaa attcagcgag agcaaagtgg cggactaccc
     4981 ataaaagccc gattggtgag ggctaattaa agcttcactt tatcaattaa aaaacattag
     5041 ttttatatat gtacgtgccg acaaagaata tagccattat taatggatat attcaatcat
     5101 tcaagtgaaa gagtaacaat aagatatata gatgtaatca agaggtgatt gataaagcaa
     5161 tgactagatt taaaatctaa tcattgcttt tttcttatgg ttttatcatc aaatatctgt
     5221 ctggtttagg gattgatttc ttctagctaa tgaatttatt acaactttgt aaggttaatg
     5281 taatgttaat cgatagtaag tgaagatgct tgagtgtaat ttaaataaga ttaaaaagta
     5341 ctgtttatct ataaaataat tgggtaaata atatgtaatt aggaagtgta tgaatatgat
     5401 tgaactaaaa tctattatcc attcgtataa actaaagaga aaaatagcta aagatttata
     5461 cggaaaaaga gatgaattga cactgttatt aaatgaattt aataaaatga aatgtacagt
     5521 aacatctgaa aagaagaaaa acaatatatt atctcgtttg caactaattt atcaaaatat
     5581 gaaattagat aagcagtatc ctctatcagt tgcttttgat agtaaattat tggagcgatt
     5641 agaaaaagaa cctctacata ctattgagga tggtgtaaca tgtttacatc taatgttaga
     5701 tgtgaattat gagaaaataa aacaatatgg ttcgagtaca agtaggtcat ttgttccatt
     5761 atcgcagtct tctatttgtc ttgctgattg tatttgttta acaggagttg tagtaggttt
     5821 actaggagca atttcatttg ggggattact gttatctata tgttcaatta cataaaggtt
     5881 gatatttgta aaaagggcac cgaattaagg tgttcttttt tggttttttt gtaaagatat
     5941 tgtaaatgat aagtacaatg cattaagtgt aatgtataat tcgaatgtat caaaatttaa
     6001 atataataga ggtgttatac atgataatta ctttgaattt ttaaaagagt cggtttgata
     6061 ataatttatg tagataaaca gtttttacgt ttcttttaaa tacttggttt aaatgaatta
     6121 gattaagtaa ctattgttct agctttttga taatcaagac aactgaagaa aggaaggaat
     6181 cattttatga aaaaattaag gctgctaaca tttgaaaata tagtagaacc ccttttaaat
     6241 gaaaaggtat catttatata ctttcctatt gaatggctgg acatcgtaga gatacattat
     6301 aagacatttt tattaacgag taagttgaaa cgtttgaatg aaagattgta tgatatgttt
     6361 tcggatatat tgtttattca gcataacccg tacgtattaa atgaaaatac accatggatt
     6421 gtatcgaaag aacctattag acaagagcag ctcgattata tttttcaaag ttggtatgag
     6481 attattcatg attggaaacc aaatagatta gtagaaccac caaaatatga atggcaatcc
     6541 gatttgattt ctaatttgcc agtactacat gatattgaaa cgtattctaa gtgggtgccc
     6601 gctttaatct cacatatttt ttgtgagcgt cctatatatt tagaaaatac aaatgaagaa
     6661 gaaatctatt tttcccctct tagatcacaa aatatttgtg aggcgatgtc agggccgata
     6721 aaagatgaaa aaacacaaga ttttttctcc tatgtatatc gattcgaatg cataacccgc
     6781 ggtggtgaga acgctccatt attaaatatt tcaataggga ttcggagatt ttatcaagaa
     6841 tataagatga taggtcaaac aaaccttgat atgacaacgt ttgtttgact ttttttgatg
     6901 aaatgcaaac attttgcaaa cataggttat ccaaagatac ttttaccgaa gtttttaact
     6961 gcttcttcct gcatatttgg taaaacatga gaatagacac ttaatgtcat tgaaatatct
     7021 gtatgaccta atcgctcact gatgatttta gggttaactc cttgttttaa tagtagagtt
     7081 gcgtgtgtat gtcttaaatc atggaattta atttctttta tacctacttt gtgtgtcgtc
     7141 ctaatgaaac tttttctgaa atgtgctctt ttgattattc ttccaaactc attacaattt
     7201 attaaatctt gatctagata agcagaacca aactttaatt tctctttatt gattaaaatt
     7261 ttatgttttt ttaaggctgc tattgtttca ttaggtacag gaattgtacg ttttgatgaa
     7321 tttgtttttg cagttttttt gattttattg tcatgaccag atgtttgatt tattgtaaca
     7381 gtatgttttt caaaatcaat gtcctgccat cgtaaaccta aaacttctcc cagacgcata
     7441 cctgtagtta ttgcaagtag atacccaatg tgatatcgtg attcttgtga atgagctaaa
     7501 aactttttta cttcttcctc tgtccaagtc tggatagggg ttttttcttt tttaggtatc
     7561 tcagcaaaat ctgctggatt tcgagaaata atattttgtt ttatggctag gtttaaagcg
     7621 ctctttaaaa ttctatgcat aagtagaata gaattgtttg caatcccttt atctatcgca
     7681 gtcttatagc atttttgaat gtgcataaca tttaatttat ggagcgcgac cattcctata
     7741 ctaggtaaaa catgtaggtt gataaatgcc ctatagccag caaaggtact cttttctatg
     7801 ctcatacttt taatttctag ccaatgattt agataatcct ttaacgtaac tttagatggt
     7861 tctataaaag ttccttcatt caactctgta atcttctttg ccacatcggc ctgtgcttct
     7921 ttttttgtct tatatccaga aaaccacttc tgtcttcttt ttcctgtctc tggatcagga
     7981 ccgatatcaa taacgatgca atatttattt cctctttttc gaatatgtcc tttcacttaa
     8041 aacactcctt cattttgttt tgaatcatgt tgtataagtc tagttgtaat tttgctgcta
     8101 tgaaaattac atgtttggac atatcagcga tggatatatt ttaccatata aaaataaatt
     8161 cagttatagt gtaggagatt catttgttgt taaacaatag tgaaaagtct actccgatta
     8221 ttaaatgcaa tattgcatat tttttaggaa gtctaaaaaa caaggagtat attaatattt
     8281 ttaattttct caagtatttt cagaatatga gagaatagat gtttgggtta tttgtgatag
     8341 aatattctta ataatataat ttgacggaac gaaaaagacc catagcgtgt gtaactgtgc
     8401 tgggaacact tttacaccgt ttgccctaat tgtagtaggg aaaacatttg ccatgagcct
     8461 tttagttacg actttgcgta acatatacgg ctagtataac acaactttta gatgtaattc
     8521 atcattaagg tgcgttttca tgatagggaa gtgtgtcttg ttccaataag ggggacaaaa
     8581 catgtggaaa gctctaaatc aaattgaaaa agagttatgt gcagctggaa taaggaaaaa
     8641 taaactagca aattattggg gagttaagcc aagtactgtt acaaaagttt ttaaaggtaa
     8701 cacagacatg agttttggct ttctttctaa gacagtcatc ctattaaaca aaggcataca
     8761 ggttcaagaa aatttattaa cagattatat acatataacg aaaccaaaat cagaaaactt
     8821 acgtgaggca atggaggatt tagctttaag gggaaagttt aatctattaa ttaatattat
     8881 aaatagtgag tcacaatcaa aggtagcaga aaatagagaa tttgctaatg tgtatcgaat
     8941 tatatataga cgatatatag gtgagattga tgctatacag taccatgagg cattaagcct
     9001 cgaaagtaaa tcaataagaa cctcagagat ggaagtgtta attgaaattt tattatgtca
     9061 agcgcaatat caatcgggta attttactgc tttaaatgag cgattaaaat ctcttgaaat
     9121 aaaaataaat aaaataagta ataggtacat tcgagaatgt tataaattac gatataaaga
     9181 agccattgcg gttacttcgt tgcagggtgg tgaagtcatt gaagcaaggc atgttagcat
     9241 ggaactattg gatgatcttg aatgggataa ctttttttct tttcccaaag taaatgcata
     9301 tttaaagcta ggagaatcgt atattttttc agcgaatgaa tatgagaagg caaaatatta
     9361 tttggaaaag actcttgaag tgctaggtga tagtaagatt aatggaattg agcgaaaaag
     9421 aaaaatggtg caacatacat tatcatttct aaagattcat catgataaag aaattagtag
     9481 cgtagatgtt gttcatccag gtgaactagc atatttaagg attaaacaag gtaagaggat
     9541 tgaagcgaga aaactattga ttcaattaaa agagaagaat ggaagattaa cagacataca
     9601 gactgcatat ttaggtttaa catatgaagg tactaaaaag gaagagttaa tgaaacgttc
     9661 tcttttgatg tgtcaaaaat cagggaatat attttattcg aatttaccaa aaatacactt
     9721 gggtttaatt tga
//
