LOCUS       NC_007530.2            10267 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  NC_007530.2 Bacillus anthracis str. 'Ames Ancestor', complete
            sequence.
ACCESSION   NC_007530
VERSION     NC_007530.2
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 6.1.1
            Run date     :: 2024-03-14 14:17:48
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 2489952
            Orig. end    :: 2500219
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..10267
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[2494952:2495219](+)"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193)"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      5001..5267
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193)"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
     cand_cluster    1..10267
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193)"
                     /kind="single"
                     /product="RiPP-like"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..10267
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="RiPP-like"
                     /region_number="5"
                     /rules="(strepbact or Antimicrobial14 or Bacteriocin_IId or
                     BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or
                     Lactococcin or Antimicrobial17 or Lactococcin_972 or
                     Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or
                     TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or
                     TIGR03975 or DUF692 or TIGR01193)"
                     /tool="antismash"
     CDS             complement(621..953)
                     /gene_functions="regulatory (smcogs) SMCOG1136:GntR family
                     transcriptional regulator (Score: 74.3; E-value: 1.9e-22)"
                     /gene_kind="regulatory"
                     /locus_tag="ctg1_2561"
                     /transl_table=11
                     /translation="MTTSKKLPKYRQIVDYMKEKIENGEWTIGSKIPSQRQLAKLFQVN
                     RSTVITALDELMADGLIQGKIGAGTIVTNNTWSLLATNPPPDWSEYVKAGIHKPSKLMV
                     REINEA"
     PFAM_domain     complement(738..929)
                     /aSDomain="GntR"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00392.23"
                     /description="Bacterial regulatory proteins, gntR family"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_2561_0118"
                     /evalue="6.10E-17"
                     /label="ctg1_2561"
                     /locus_tag="ctg1_2561"
                     /protein_end="72"
                     /protein_start="8"
                     /score="61.1"
                     /tool="antismash"
                     /translation="KYRQIVDYMKEKIENGEWTIGSKIPSQRQLAKLFQVNRSTVITAL
                     DELMADGLIQGKIGAGTIV"
     CDS             1102..2016
                     /gene_functions="transport (smcogs) SMCOG1166:transporter,
                     EamA family (Score: 203.9; E-value: 5.8e-62)"
                     /gene_kind="transport"
                     /locus_tag="ctg1_2562"
                     /transl_table=11
                     /translation="MNYKKWDLRIICAHAFTILIWGSAFPAIRMGLESYTPEHLTLLRL
                     LIASVILLLFSFIYKLRLPDLKDIPAIFIFGALGFTFYHIALNYGEKTVNAGSASLIVS
                     VTPIVTAIFASVFMNEKMKLNGWIGGVISFIGIAFISFSQGDAIQLNSGALFILLAAIS
                     ESLFFVFQSSYLKKYGFLPFTIYTILSSTVCMLIFLPGMYQEILAAPLEVNLSVIYLGV
                     FPTVLPYIALAYIISRAGASEATSSLYLTPITACFVAWIWLGEVPTLVSIIGGGITILG
                     IVIVHIPVLRKEKHSNLANNQSV"
     PFAM_domain     1147..1527
                     /aSDomain="EamA"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00892.22"
                     /description="EamA-like transporter family"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_2562_0119"
                     /evalue="7.50E-28"
                     /label="ctg1_2562"
                     /locus_tag="ctg1_2562"
                     /protein_end="142"
                     /protein_start="15"
                     /score="97.5"
                     /tool="antismash"
                     /translation="FTILIWGSAFPAIRMGLESYTPEHLTLLRLLIASVILLLFSFIYK
                     LRLPDLKDIPAIFIFGALGFTFYHIALNYGEKTVNAGSASLIVSVTPIVTAIFASVFMN
                     EKMKLNGWIGGVISFIGIAFISF"
     PFAM_domain     1555..1956
                     /aSDomain="EamA"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00892.22"
                     /description="EamA-like transporter family"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_2562_0120"
                     /evalue="9.80E-20"
                     /label="ctg1_2562"
                     /locus_tag="ctg1_2562"
                     /protein_end="285"
                     /protein_start="151"
                     /score="71.2"
                     /tool="antismash"
                     /translation="SGALFILLAAISESLFFVFQSSYLKKYGFLPFTIYTILSSTVCML
                     IFLPGMYQEILAAPLEVNLSVIYLGVFPTVLPYIALAYIISRAGASEATSSLYLTPITA
                     CFVAWIWLGEVPTLVSIIGGGITILGIVIV"
     CDS             2155..3516
                     /locus_tag="ctg1_2563"
                     /transl_table=11
                     /translation="MNGKRNIFTCISIVGIGLASFSNSSFAASVTDNSIQNSIPVVNQQ
                     VAAAKEMKPFPQQVNYAGVIKPNHVTQESLNASVRSYYDNWKKKYLKNDLSSLPGGYYV
                     KGEITGDADGFKPLGTSEGQGYGMIITVLMAGYDSNAQKIYDGLFKTARTFKSSQNPNL
                     MGWVVADSKKAQGHFDSATDGDLDIAYSLLLAHKQWGSNGAVNYLKEAQDMITKGIKAS
                     NVTNNSRLNLGDWDSKSSLDTRPSDWMMSHLRAFYEFTGDKTWLTVINNLYDVYTQFSN
                     KYSPNTGLISDFVVKNPPQPAPKGFLNESEYTNVYYYNASRVPLRIVMDYAMYGEKRSK
                     VISDKVSSWIQNKTNGNPSKIVDGYQLNGSNIGNYPTAVFVSPFIAASITNSNNQKWVN
                     SGWDWMKNKRESYFSDSYNLLTMLFITGNWWKPIPDNKKTQNQINDAIYEGYDN"
     PFAM_domain     2398..3426
                     /aSDomain="Glyco_hydro_8"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF01270.19"
                     /description="Glycosyl hydrolases family 8"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_2563_0121"
                     /evalue="7.40E-28"
                     /label="ctg1_2563"
                     /locus_tag="ctg1_2563"
                     /protein_end="424"
                     /protein_start="81"
                     /score="97.4"
                     /tool="antismash"
                     /translation="YYDNWKKKYLKNDLSSLPGGYYVKGEITGDADGFKPLGTSEGQGY
                     GMIITVLMAGYDSNAQKIYDGLFKTARTFKSSQNPNLMGWVVADSKKAQGHFDSATDGD
                     LDIAYSLLLAHKQWGSNGAVNYLKEAQDMITKGIKASNVTNNSRLNLGDWDSKSSLDTR
                     PSDWMMSHLRAFYEFTGDKTWLTVINNLYDVYTQFSNKYSPNTGLISDFVVKNPPQPAP
                     KGFLNESEYTNVYYYNASRVPLRIVMDYAMYGEKRSKVISDKVSSWIQNKTNGNPSKIV
                     DGYQLNGSNIGNYPTAVFVSPFIAASITNSNNQKWVNSGWDWMKNKRESYFSDSYNLLT
                     MLF"
     CDS             3892..4329
                     /locus_tag="ctg1_2564"
                     /transl_table=11
                     /translation="LLRENWEDALKLQVKDNQTKFVPSVAVSLAKVYIKPDGDAVEYQP
                     FAIYNGDLMVGFVMHAVVKETTDMYWINGFIIDQKQQGNGYGKAALQESIYLIKNTFKA
                     CKEIRLTVHKDNISAKKLYESYGFQPLGHDYDGEEVYRLFV"
     PFAM_domain     4027..4275
                     /aSDomain="Acetyltransf_1"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00583.27"
                     /description="Acetyltransferase (GNAT) family"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_2564_0122"
                     /evalue="9.10E-11"
                     /label="ctg1_2564"
                     /locus_tag="ctg1_2564"
                     /protein_end="128"
                     /protein_start="45"
                     /score="42.1"
                     /tool="antismash"
                     /translation="FAIYNGDLMVGFVMHAVVKETTDMYWINGFIIDQKQQGNGYGKAA
                     LQESIYLIKNTFKACKEIRLTVHKDNISAKKLYESYGF"
     CDS             4352..4798
                     /locus_tag="ctg1_2565"
                     /transl_table=11
                     /translation="LKNKFHHIVRAVMIKDKKLIVAEYIGHHYFLPGGHVEVGESAESA
                     LIRELQEELGVNCSIKQFLGVIENQWQDKEMLHHEINHIFEIDSEELHIDFIPKSKEPH
                     LAFHWIDYNRDALHTYKIMPAPSVKELLERKLSDELLNCWISNF"
     PFAM_domain     4370..4690
                     /aSDomain="NUDIX"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00293.30"
                     /description="NUDIX domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_2565_0123"
                     /evalue="1.40E-14"
                     /label="ctg1_2565"
                     /locus_tag="ctg1_2565"
                     /protein_end="113"
                     /protein_start="6"
                     /score="54.3"
                     /tool="antismash"
                     /translation="HIVRAVMIKDKKLIVAEYIGHHYFLPGGHVEVGESAESALIRELQ
                     EELGVNCSIKQFLGVIENQWQDKEMLHHEINHIFEIDSEELHIDFIPKSKEPHLAFHWI
                     DYN"
     aSDomain        5001..5258
                     /aSDomain="TIGR03601"
                     /aSTool="tigrfam"
                     /description="B_an_ocin: bacteriocin,
                     heterocycloanthracin/sonorensin family"
                     /detection="hmmscan"
                     /domain_id="TIGRFam_ctg1_2566_0021"
                     /evalue="3.20E-36"
                     /identifier="TIGR03601"
                     /label="ctg1_2566"
                     /locus_tag="ctg1_2566"
                     /protein_end="86"
                     /protein_start="0"
                     /score="121.8"
                     /tool="antismash"
                     /translation="MNQFQQELQSLNLNDYQTGNVVYWDPQQSQYPYYYIQDDARRCGG
                     CGGCGGRCGGCGGRCGGCAGRCGGCIGCAGCFGCFNCWNWW"
     CDS             5001..5267
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: TIGR03601"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg1_2566"
                     /sec_met_domain="TIGR03601 (E-value: 8e-48, bitscore:
                     159.1, seeds: 6, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNQFQQELQSLNLNDYQTGNVVYWDPQQSQYPYYYIQDDARRCGG
                     CGGCGGRCGGCGGRCGGCAGRCGGCIGCAGCFGCFNCWNWWII"
     CDS             5369..6385
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1053:beta-lactamase (Score: 74.4; E-value: 1.6e-22)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg1_2567"
                     /transl_table=11
                     /translation="LYTYDKLISWVEDIKEKNHSSATALCIIKDNKIVLEHYSGYHSNT
                     SRNEKVSASSQFNVASARKSYLGLMIAYALYEGKINSIDDEAIKYFKDFDHALLGKTTI
                     RHLVTHSHGLGETNDGKIFREFEPGQSWAYRDINVRMMTRLIYQLYNKSFPELLKERVF
                     KPANFQETGWRIQQDDNLVAVVDDPNKDAISEIGTVDDGTEKNLFVSAREFAQWGNLHL
                     NQGMIDDKQIVPKEVIKIATSLQSPTYANKELPQNGLFWFVQNEPAQLSELGERVPKGS
                     YQILGITGPTILVIPEYNVVVAKMYNKRYNYGGDNYLYYLREFSNLVVDTFRNSNRV"
     PFAM_domain     5396..6316
                     /aSDomain="Beta-lactamase"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00144.26"
                     /description="Beta-lactamase"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_2567_0124"
                     /evalue="3.00E-36"
                     /label="ctg1_2567"
                     /locus_tag="ctg1_2567"
                     /protein_end="316"
                     /protein_start="9"
                     /score="125.4"
                     /tool="antismash"
                     /translation="WVEDIKEKNHSSATALCIIKDNKIVLEHYSGYHSNTSRNEKVSAS
                     SQFNVASARKSYLGLMIAYALYEGKINSIDDEAIKYFKDFDHALLGKTTIRHLVTHSHG
                     LGETNDGKIFREFEPGQSWAYRDINVRMMTRLIYQLYNKSFPELLKERVFKPANFQETG
                     WRIQQDDNLVAVVDDPNKDAISEIGTVDDGTEKNLFVSAREFAQWGNLHLNQGMIDDKQ
                     IVPKEVIKIATSLQSPTYANKELPQNGLFWFVQNEPAQLSELGERVPKGSYQILGITGP
                     TILVIPEYNVVVAKMYNKRYNYGGDN"
     CDS             6417..6560
                     /locus_tag="ctg1_2568"
                     /transl_table=11
                     /translation="VKDKVNKNKKQNIKDVNTEQNAIYSDPKDAANMQTVPQPKDFDEI
                     EY"
     CDS             6845..8053
                     /gene_functions="transport (smcogs) SMCOG1137:Major
                     facilitator superfamily MFS 1 (Score: 420; E-value:
                     1.3e-127)"
                     /gene_kind="transport"
                     /locus_tag="ctg1_2569"
                     /transl_table=11
                     /translation="MKQTSINPLLIVLGTIIVQIGLGTIYTWSLFNQPLVSKFGWNLNS
                     VAITFSITSFSLSFSTLFAGKLQQKLGLRKLIATAGIVLGLGLILSSQVSSLPLLYLLA
                     GVVVGYADGTAYITSLSNLIKWFPNRKGLISGISVSAYGMGSLIFRYINGNLIDNLGVS
                     QAFLYWGIIVLLLVLIGSFFLREAIVSNAVTETLHNDYTPREMMGTKQVYLLFFMLFTS
                     CMGGLYLIGMVKDIGVQLVGLSTATAANAVAMIAIFNTVGRIVLGTLSDKIGRMKIVSA
                     TFIIIGLSVFTLSFIPLNYGIYFACVASFAFCFGGNITIFPAIVGDFFGLKNHSTNYGI
                     VYQGFGFGALAGSFIGAILGGFQPTFIIIGVLSVISFIISILIRPPNAEKKNELKHLHR
                     KVA"
     PFAM_domain     6902..7807
                     /aSDomain="MFS_1"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF07690.18"
                     /description="Major Facilitator Superfamily"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_2569_0125"
                     /evalue="1.00E-23"
                     /label="ctg1_2569"
                     /locus_tag="ctg1_2569"
                     /protein_end="321"
                     /protein_start="19"
                     /score="84.0"
                     /tool="antismash"
                     /translation="IGLGTIYTWSLFNQPLVSKFGWNLNSVAITFSITSFSLSFSTLFA
                     GKLQQKLGLRKLIATAGIVLGLGLILSSQVSSLPLLYLLAGVVVGYADGTAYITSLSNL
                     IKWFPNRKGLISGISVSAYGMGSLIFRYINGNLIDNLGVSQAFLYWGIIVLLLVLIGSF
                     FLREAIVSNAVTETLHNDYTPREMMGTKQVYLLFFMLFTSCMGGLYLIGMVKDIGVQLV
                     GLSTATAANAVAMIAIFNTVGRIVLGTLSDKIGRMKIVSATFIIIGLSVFTLSFIPLNY
                     GIYFACVASFAFCFGGNITIF"
     CDS             8500..8955
                     /locus_tag="ctg1_2570"
                     /transl_table=11
                     /translation="VGFSMIIFLSIVGSLSSFFIPVSWIGVLGFVPIYMGVKGLFSLRS
                     NKSNKVIDKASSSLFKVAAITLANGADNISIYIPMFTSQSLEANIVTLIIFFCMIAIWC
                     SISYTLLRAPILAKVLERNCHIIVPIVLIGLGMFILFRSNTIELLYL"
     PFAM_domain     8503..8949
                     /aSDomain="Cad"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF03596.15"
                     /description="Cadmium resistance transporter"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_2570_0126"
                     /evalue="7.50E-27"
                     /label="ctg1_2570"
                     /locus_tag="ctg1_2570"
                     /protein_end="150"
                     /protein_start="1"
                     /score="94.6"
                     /tool="antismash"
                     /translation="GFSMIIFLSIVGSLSSFFIPVSWIGVLGFVPIYMGVKGLFSLRSN
                     KSNKVIDKASSSLFKVAAITLANGADNISIYIPMFTSQSLEANIVTLIIFFCMIAIWCS
                     ISYTLLRAPILAKVLERNCHIIVPIVLIGLGMFILFRSNTIELLY"
     CDS             9589..10032
                     /locus_tag="ctg1_2571"
                     /transl_table=11
                     /translation="MKKVNVTYALLYDKTNEKILMVKNKGKNGSYYTLPGGAVKLGETL
                     EEAVIREVKEETGLHITVNGICYISEAFFEERGHHAIFFNFLGEIIGGETNITRPKEIE
                     EITWMELHIASPHLRIPEHLVNMLKKKETVPYFFNGTIVHQSS"
     PFAM_domain     9607..9930
                     /aSDomain="NUDIX"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00293.30"
                     /description="NUDIX domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_2571_0127"
                     /evalue="2.20E-16"
                     /label="ctg1_2571"
                     /locus_tag="ctg1_2571"
                     /protein_end="114"
                     /protein_start="6"
                     /score="60.2"
                     /tool="antismash"
                     /translation="TYALLYDKTNEKILMVKNKGKNGSYYTLPGGAVKLGETLEEAVIR
                     EVKEETGLHITVNGICYISEAFFEERGHHAIFFNFLGEIIGGETNITRPKEIEEITWME
                     LHIA"
ORIGIN
        1 ctaccgatat ataatacatg tccatgttta tcccttgatt ttaaaggagc tgggggcggt
       61 gcatcaatcc ataactcgcg gtaaatatca tcttcaataa taggtaactg ttccttttca
      121 catattttta atatttcttt tctccgctct ttagacatta atatgcctgt tggattttga
      181 aaacaaggaa ttgaatataa aatgtttttc ttctgactgt atttaattcg ttttaataac
      241 tcgttaggta atataccgtg aggatccata gatataccag atagatttat atttgctgat
      301 tgaaatacat gaagtgaata taagtaagaa ggttgttcaa gtaaaatggt tgactctcta
      361 tgtaaaagac caattgatat taattgcaat gcttgtaatg cacccgagac gattaatatg
      421 gaacttggtg atgcatgtat tccaaatgat tttacgtatt tacttattgc ttcacgtaac
      481 ggataaaacc ctttttgttc ctcatatcca aaatagtcta attcctcact tactttcttc
      541 ataatggact gcatcgtttc taatggaaaa agatgaggag aaagttcgcc tttactaaga
      601 tggataagct tgttatttgc ttatgcttca tttatttctc gtaccattaa cttgcttggt
      661 ttatgaatac cggcctttac atattcactc caatcaggtg gtggatttgt tgctaataat
      721 gaccatgtat tattcgttac aattgttcct gctccaattt tcccttgaat caatccatca
      781 gccataagtt catctagtgc agttattaca gtgctacgat ttacttgaaa taattttgct
      841 aactgccttt gactagggat cttacttcca attgtccatt ctccattttc aattttttct
      901 ttcatataat ctactatctg ccgatactta ggcagttttt tactagttgt catcaaaaaa
      961 ctccttcgtt cacttgaaaa ataccaagtg gttggttttt acgataaaaa actggttgaa
     1021 gacattgtat caactattaa atatgatgaa aagaaataat tggtaatttg aaaatggttg
     1081 gtttgaaggg ggagagaaaa catgaattat aaaaaatggg atttacgcat tatatgtgct
     1141 cacgctttta cgattcttat atggggatct gcttttccag caatccgtat ggggcttgaa
     1201 tcttatacgc ctgagcatct gactttacta cgtttattaa ttgcttcagt tatacttctt
     1261 ttgttttcct ttatatataa gttacggcta ccggatttaa aggatatccc agccattttt
     1321 atatttggtg ctttaggatt tactttttat cacattgcac taaactatgg tgaaaaaaca
     1381 gtaaatgctg gatctgcaag tttaattgtt tcagtcacgc ctatagtaac ggcaatattc
     1441 gcttctgttt ttatgaatga aaaaatgaaa ttaaatggtt ggatcggtgg tgtaattagt
     1501 tttataggaa ttgctttcat atcatttagt caaggagatg ctattcaatt aaatagtggg
     1561 gcattattta tattattagc agcgatttca gaaagcttat ttttcgtttt ccaatcttct
     1621 tacttaaaaa agtacggttt cttgccattt accatatata caattttatc tagtacggta
     1681 tgtatgctta ttttcttacc aggaatgtat caagaaatac tagcagctcc tcttgaagtt
     1741 aacttgagcg ttatatattt aggtgtcttt ccaacagtac tcccatatat tgcattggcc
     1801 tatattatat ctcgtgctgg tgcttctgaa gcaacaagtt ctctatattt aacgccaata
     1861 actgcatgtt ttgtcgcttg gatatggtta ggagaagtgc caactttagt ttcgataatt
     1921 ggcggaggga ttactatact tggaattgtg attgttcata taccagtatt aagaaaagaa
     1981 aaacatagca atttagcaaa taatcaatcc gtataatgta attaaataat gattttatga
     2041 tactttttta tatagtttct ttctcatgtt gataaatata atattttgta tttcagttaa
     2101 atattgtatg ttacatttta tgtagtaagc attttaaaag gagctgacaa cataatgaat
     2161 ggaaaaagaa atatttttac atgtatttct attgtaggaa tcggactagc tagtttttct
     2221 aattctagtt tcgcagcaag tgtaacggac aattcaatac aaaattctat tcctgtagtt
     2281 aatcaacaag tagctgctgc aaaggaaatg aaaccatttc cccagcaagt taattatgca
     2341 ggtgttataa aaccgaatca tgttacacaa gaaagtttaa atgcttctgt aagaagttac
     2401 tacgataatt ggaaaaagaa atatttgaaa aatgatttat cttctttacc tggtggttat
     2461 tacgtaaaag gagagattac aggtgatgcg gatgggttta agccacttgg aacttcagaa
     2521 ggtcaagggt atgggatgat aattacagta ttaatggctg gttatgattc gaatgctcaa
     2581 aaaatctatg acggtttatt taaaacagca agaactttta aaagctctca aaatcctaat
     2641 ttaatgggat gggttgtcgc agatagtaaa aaagcacaag gtcattttga ttctgctact
     2701 gatggggatt tagatattgc gtattctctt cttcttgctc acaagcagtg gggatcaaat
     2761 ggagcagtta attatttaaa agaagcacaa gacatgatta caaaaggtat taaagctagt
     2821 aatgttacaa ataatagccg actaaattta ggagattggg attctaaaag ttcacttgat
     2881 acgagaccat ctgattggat gatgtcacac cttagagcat tttatgaatt tacaggtgat
     2941 aaaacttggc tcactgttat taataatttg tacgatgttt atacgcaatt tagtaataag
     3001 tactctccaa atacaggact tatttcagat tttgttgtaa aaaacccacc acaacccgca
     3061 cctaaaggct tcttaaatga gtcagaatat acaaatgtat attattataa tgctagtcga
     3121 gtacctttaa gaattgtaat ggactatgcg atgtacggcg agaagcgaag taaagtcatt
     3181 tctgataaag tatcttcatg gattcaaaat aaaacgaatg gaaatccttc taaaattgtg
     3241 gatggttatc aattaaacgg atccaatatt ggtaattatc caactgctgt attcgtttcg
     3301 ccatttattg ctgcaagtat aacaaatagc aataatcaaa agtgggtaaa tagcggttgg
     3361 gattggatga agaataagag agaaagctat tttagtgata gttataattt attaactatg
     3421 ttatttatta caggaaattg gtggaaacct atacctgata ataaaaagac acaaaatcaa
     3481 ataaatgatg caatttatga aggatacgat aattaattaa aattgagaat ggttacttaa
     3541 gaaaggaatt agcatacgct agttcctttt ccatctattg aaggaccttt gttacatgat
     3601 gtggttacta taagtagatt agttaactca agttttttaa atttgcgcac catacagtga
     3661 atgtagatac aaacggagat acgaaaggac aaacatttgc tgatttttgc cctagcttaa
     3721 tatctaaagg ggcccgtata tcattagaaa taggtgaaca taaatttatt caagatttta
     3781 taaaaattac gttataggtt gttgtcgaaa aaggaaatta tttcactacg ttgaattaaa
     3841 aatatatcct ctttataaag gagattatca tattgaatat ccagttaaag gttgttacga
     3901 gagaattggg aagatgcttt aaagctgcaa gttaaagata atcagacgaa atttgttcca
     3961 tctgtagcag tttcacttgc taaagtatat ataaaaccag atggggacgc tgtagaatac
     4021 caaccatttg cgatatacaa cggcgatcta atggttggtt ttgttatgca tgctgttgta
     4081 aaagaaacaa ctgatatgta ttggataaac ggatttatta tcgatcaaaa gcagcaaggt
     4141 aacggttatg gaaaagcggc attacaagaa agtatatact taataaaaaa tacgtttaag
     4201 gcgtgtaaag aaattagatt aacagtacat aaagataata tctctgcaaa gaaattatat
     4261 gaaagttacg gttttcaacc attgggacat gattatgatg gtgaggaagt ttatcgttta
     4321 ttcgtttaac aatgaatggg aggaataaca attgaaaaat aaatttcatc atattgtacg
     4381 agctgttatg ataaaggata aaaaattgat agtagctgaa tatattggcc atcattattt
     4441 tctaccaggt ggtcatgttg aagttggcga atcagctgag agtgcattaa taagagaact
     4501 acaagaagaa cttggagtaa attgtagtat aaaacaattt ttaggagtca tagaaaacca
     4561 atggcaagat aaagaaatgc ttcatcatga aatcaatcat atttttgaga tagattcaga
     4621 agagttacat attgatttca taccaaaatc taaagaacct catttagcgt ttcactggat
     4681 agattataat cgagacgctt tacatactta taaaatcatg ccagcacctt ccgttaaaga
     4741 gttactagaa agaaaattaa gtgatgaact actaaactgt tggattagca atttttaaat
     4801 acctctatta atagtaaatc tgtccagcaa aaagtgatta agaaaatagg ctaagaaaca
     4861 aggtacatca cctagtgtaa gttcatattt tgttgatgta cgcattcaag tatatagcca
     4921 tttgtttcta ctttgtttat taaaatttat taactttaat ttttggacgg aatttatatt
     4981 gataaatgga gggttttata atgaatcagt ttcaacaaga actacaatca ttaaacctta
     5041 atgattatca aactggtaat gttgtgtatt gggatccaca acaaagtcaa tatccatact
     5101 actatattca agacgatgca cgtcgttgcg gcggatgcgg aggttgtggt ggacgctgtg
     5161 gcggatgtgg cggcagatgc ggtggttgtg caggtcgttg cggcggatgc ataggttgcg
     5221 caggatgttt cggttgcttt aattgctgga actggtggat catttaagta tagaacatca
     5281 aagctacttt gcttgaagga aaggtgtgaa aactattttg cacttttctt tcaagctgta
     5341 atttttgtgt atatcaaggg ggatttattt gtatacatat gataagttaa tttcttgggt
     5401 agaggatatt aaagaaaaaa atcatagttc tgcaacagcg ctttgtatta taaaagataa
     5461 caaaattgta ctagagcatt atagtggata tcactcaaat acatcgagaa atgaaaaagt
     5521 aagcgcatct tcacaattta acgttgcttc tgctagaaaa agttatttag gattaatgat
     5581 agcgtatgcg ctttacgagg ggaaaataaa ctctattgat gatgaagcga taaaatattt
     5641 taaagacttt gatcatgcat tgcttggtaa aacaacgata aggcatttag taacacattc
     5701 gcacggttta ggagaaacga atgacggaaa aatttttcgt gaatttgaac ctggacaatc
     5761 ttgggcgtat agagatatta atgtaagaat gatgacacgt cttatttatc agctatataa
     5821 caaaagtttt cctgaattgt taaaagagcg tgtgtttaaa cctgctaatt tccaagaaac
     5881 aggatggaga atacagcaag atgataattt agttgcagtt gttgatgatc caaataaaga
     5941 cgcaattagt gaaattggta cagtagatga cggtactgaa aaaaatctgt ttgtctccgc
     6001 tagagaattt gcgcagtggg gcaaccttca tttaaatcaa ggtatgatag atgataaaca
     6061 aattgttcca aaagaagtta taaaaatcgc tacgagtttg cagagtccaa catatgcaaa
     6121 taaagagcta ccacaaaatg gcttgttttg gttcgttcaa aatgaacctg cacaattaag
     6181 tgaactaggc gaacgtgtac caaaaggctc gtatcaaata ttaggaatta cgggaccaac
     6241 tatattagta atacctgaat ataatgtagt tgttgcgaaa atgtataata aaagatacaa
     6301 ctacggcggt gataattatt tatattattt acgtgaattt agtaatttag tcgttgatac
     6361 atttcgtaac agtaataggg tataattact cctataacaa aaaggagtga ttgaaagtga
     6421 aagataaagt gaacaaaaat aaaaagcaaa atataaaaga tgtaaataca gagcaaaatg
     6481 cgatctatag cgatccaaaa gatgcagcta atatgcaaac ggtaccgcag ccgaaagatt
     6541 ttgatgaaat tgaatattaa tttttcgttt atccgaccat atgatgaatc aaaaatacat
     6601 cttaagtccc atcacatgat tgaaaacttt tggtactcta tatacataag catttgaaaa
     6661 tgtcttatct taacaaagct ttctttaagt aaatctaata taacctgcaa aaagacactt
     6721 cataatggag tgtctttttg tgtacatgaa ttcaatttcc atttttcatg cagtatcttg
     6781 ctttttatga tggttatact aactgtgaaa attcatgtca cgataaaaga aggggacagt
     6841 tagtatgaaa caaacttcta taaatccgtt actaattgtt ctaggtacaa tcattgttca
     6901 aattggcctt ggaacaattt atacatggag tttatttaat cagccccttg taagtaagtt
     6961 tggatggaac cttaattcag ttgctataac tttctccatt acaagcttct ctttatcatt
     7021 ttcaacatta tttgcaggaa agttacagca aaaattaggg cttcgaaaac tcatcgctac
     7081 tgcagggatt gtgctgggac tcggtttaat actaagttca caagtttcct ccttaccatt
     7141 actatattta ttagctggtg tagtagttgg ttatgccgat ggaactgctt atatcacatc
     7201 actatctaat ttaattaaat ggtttccgaa tcggaaaggg cttatttcag gtatatctgt
     7261 atcagcatat ggaatgggca gcttaatctt tagatatata aacggaaatc ttatcgataa
     7321 tcttggtgta tcacaagcat tcttatattg gggtattatc gtattacttt tagtgttaat
     7381 tggatcgttc ttcttacgtg aagcgattgt aagtaatgct gtaactgaaa cattacacaa
     7441 tgactatact ccgcgtgaaa tgatgggaac gaaacaagta tatctcttgt tttttatgtt
     7501 atttacatcg tgtatgggtg gtctgtattt aatcggtatg gtaaaagata ttggggtaca
     7561 actcgttgga cttagtacag caactgccgc taacgctgtt gcaatgattg caatttttaa
     7621 tacagtaggt cgtattgttc ttggaacgtt atcagataaa ataggtcgaa tgaaaattgt
     7681 ctctgcaacg tttattatta taggtttgtc agtctttact ttaagtttta ttccgctaaa
     7741 ttacggaatc tattttgctt gtgtagcaag tttcgccttt tgcttcggtg gtaatataac
     7801 tatattccca gctattgtcg gagatttttt cggattaaaa aaccatagta caaattacgg
     7861 gattgtctac caaggttttg gatttggtgc gcttgcagga tcatttattg gagcgatact
     7921 cgggggattt caaccaactt tcattataat cggtgtttta agtgttattt ccttcattat
     7981 ttcaatatta atccgtccac caaatgcaga gaagaaaaat gaactaaaac atttacatcg
     8041 gaaagtagct taatacaaaa aagagtccta atatagggct cttttttgtg tagagaatag
     8101 agttatttaa tttaaagtga aatgatttga gaagcaataa agttgtttat ttcttgatga
     8161 actaagtagc agatgcgtag aatattcata ttgttttata aaggaactaa catgttgtta
     8221 aaaaacatat agaaaattac agttaaccaa ctttgtgatg gaacgtgcac ttcattcata
     8281 gatcattatt ttcttataag tttacaatga aagtagttgg cttatattga ttacaaccat
     8341 aatttcttct gttgtggcat tcgctacaac aaatattgat gatattttta tactgcttgt
     8401 tttattttca caagtaagaa cagaagtact taggaaagaa gatagagctg tccgcgaaaa
     8461 agctatgaga aaaaacttta tattgctatt ggacaatatg tggggtttag tatgattatt
     8521 tttctaagta tcgttgggtc tttaagctct tttttcattc ctgtttcgtg gattggggta
     8581 ttaggattcg tgccaattta tatgggtgtt aaaggactat tctcgcttcg ttctaacaaa
     8641 agtaataaag tcattgataa agcttctagt tcattattta aagtagctgc gattacatta
     8701 gctaatggag ctgacaatat ctcaatttat ataccaatgt tcactagtca atccttggaa
     8761 gcaaatatcg ttacattaat tatctttttt tgcatgatag caatatggtg ttctattagc
     8821 tacacattgt taagagctcc tattttagct aaagtacttg agagaaattg tcatattatc
     8881 gttccaatcg ttctaattgg tttaggaatg ttcattcttt ttcgcagtaa tacaattgaa
     8941 ttattgtact tataagttca aactaacgga atttttaagt aaaaagaatc aaacgtggta
     9001 aaaagccgta ctacaaataa aatgtagtac ggctttttta agttttagtg aaatgaaacc
     9061 gtgcactacg acaattaagt tagacaggat attacgatta ttaaattgaa tagatacttt
     9121 aaaaggagcg tgatatttaa aatgaaaata gtaaaacaga agaatataga cacgaaggtt
     9181 atggaaccaa gttaataaaa cgtattgaag aatttgcaat tgaaaaagag tgtagcctaa
     9241 tcaatttaga tacttttagc tttcaggcac ctgcttttta taaaaaacat ggatataaag
     9301 taattggagt aagtgaaaat caccctaaag ggcataatcg atactatttg gaaaaaaggt
     9361 tagaaaatat atagaatccc aaaatgaatc aatcaaatca taaagagcgt acgttgaata
     9421 attactttca aaatacgttc tttttattta gaaatgaagg gggatcgatt attaccttta
     9481 ctaaggatag ataaatgaaa tactctatta atttttttat attttaaaac gattaaatgg
     9541 tagaatgtaa caaagacaga aaattctcgt tattgaaggt ggacttagat gaaaaaagta
     9601 aatgttacat atgcgctttt atacgataaa acaaatgaaa agatcttaat ggtaaaaaac
     9661 aaagggaaga atggttctta ttacacacta ccaggtggtg cagttaaatt aggagaaacg
     9721 ttagaggagg cagtcattcg agaagtgaaa gaagaaaccg gtctacatat aactgtaaat
     9781 ggtatttgtt acattagcga agcttttttc gaagagagag gacaccatgc aatattcttt
     9841 aattttttag gtgaaataat cggaggggaa acaaatataa caaggccaaa agaaattgaa
     9901 gagattactt ggatggaatt acatatagca tcaccgcatt tacgtatacc agaacattta
     9961 gtaaatatgt taaaaaagaa agaaacggta ccttactttt ttaacggaac tatcgttcat
    10021 caatcttcat aaaaatatta tttcatttta ggtgggggaa aagatggagt ttatcgttaa
    10081 tcacaaacat tttacacaag cactttcaga tgtaagtaaa gcaatatcaa cgaaagctat
    10141 aattcctata ttatctggca taaaaataac agcagatcaa tctgggatta ctttaatcgc
    10201 aagtaattcg aatattttca tcgaaaaatt tatacctagt gctatagatg acgaacaaat
    10261 tacgact
//
