LOCUS       NC_007530.2            25239 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  NC_007530.2 Bacillus anthracis str. 'Ames Ancestor', complete
            sequence.
ACCESSION   NC_007530
VERSION     NC_007530.2
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 6.1.1
            Run date     :: 2024-03-14 14:17:48
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 2363259
            Orig. end    :: 2388498
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..25239
                     /aStool="rule-based-clusters"
                     /category="other"
                     /contig_edge="False"
                     /core_location="[2373259:2378498]"
                     /cutoff="10000"
                     /detection_rule="(HMGL-like and AMP-binding)"
                     /neighbourhood="10000"
                     /product="betalactone"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..15239
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="(HMGL-like and AMP-binding)"
                     /neighbourhood="10000"
                     /product="betalactone"
                     /protocluster_number="1"
     cand_cluster    1..25239
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(HMGL-like and AMP-binding)"
                     /kind="single"
                     /product="betalactone"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..25239
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="betalactone"
                     /region_number="4"
                     /rules="(HMGL-like and AMP-binding)"
                     /tool="antismash"
     CDS             549..2003
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1170:metallo-beta-lactamase family protein (Score:
                     138; E-value: 4.6e-42)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg1_2428"
                     /transl_table=11
                     /translation="MLLKYFYDEKLAHASYLVGCQKEGVAIVIDPGRYIEQYIDFAKKE
                     GMEVIAAAETHIHADFLSGSRELSTLYHTNLYVSDEGDCDWKYQYLNEGRYNLVREGTE
                     FKVGHIKFNVIHTPGHTPESISFLVTDTSQNNYTNDKPIGIFTGDFIFVGDIGRPDLLE
                     TAVGMKDTAKIGAKQLFDSIQKIKTLPDYLQIWPSHGAGSACGKALGAIPTSTLGYEKM
                     FNWAFQCNEESDFISTLLAGQPEPPRYFSLMKNLNKYGPPIRKKREIFAIKTVEELQEV
                     MRSVQQIVDIRDGESFASGHIEKSINIPCNNSFTTWCGWLLDYKTETLIILDEEKVRVE
                     EVIRDFESIGLDNIIAFAPLQVIQRLDRFESYKEKTSIELYPHIKDGRVKVIDVRSKKE
                     WDEGHLHDAIHIPLGNLLKQLDCIPKDCPIVLQCRTGLRSAIAASILQRAGIKEVVNLK
                     GGFLAWNKEELPYTTCNLNVEGNNFY"
     PFAM_domain     585..1133
                     /aSDomain="Lactamase_B"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00753.29"
                     /description="Metallo-beta-lactamase superfamily"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_2428_0084"
                     /evalue="9.40E-08"
                     /label="ctg1_2428"
                     /locus_tag="ctg1_2428"
                     /protein_end="195"
                     /protein_start="12"
                     /score="32.4"
                     /tool="antismash"
                     /translation="HASYLVGCQKEGVAIVIDPGRYIEQYIDFAKKEGMEVIAAAETHI
                     HADFLSGSRELSTLYHTNLYVSDEGDCDWKYQYLNEGRYNLVREGTEFKVGHIKFNVIH
                     TPGHTPESISFLVTDTSQNNYTNDKPIGIFTGDFIFVGDIGRPDLLETAVGMKDTAKIG
                     AKQLFDSIQKIKTLPDYLQI"
     PFAM_domain     1686..1946
                     /aSDomain="Rhodanese"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00581.22"
                     /description="Rhodanese-like domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_2428_0085"
                     /evalue="7.30E-14"
                     /label="ctg1_2428"
                     /locus_tag="ctg1_2428"
                     /protein_end="466"
                     /protein_start="379"
                     /score="52.3"
                     /tool="antismash"
                     /translation="LYPHIKDGRVKVIDVRSKKEWDEGHLHDAIHIPLGNLLKQLDCIP
                     KDCPIVLQCRTGLRSAIAASILQRAGIKEVVNLKGGFLAWNK"
     CDS             2114..2332
                     /locus_tag="ctg1_2429"
                     /transl_table=11
                     /translation="MDIVLSGHAQGGQFKLLFISKLVALNQGVLPTYSAGLYEKQNTSM
                     VVSRGLGNSNIPQRIFNRPELVVVQLN"
     CDS             2542..2793
                     /locus_tag="ctg1_2430"
                     /transl_table=11
                     /translation="MHKEYEIEEYTAIEEQIHYYCKCLLVTHPDQIIKYLEKRLEKYAE
                     TLQYAHLYPDTVILPLQQLVIEYSLDVARIRKYMNLKT"
     CDS             3038..3706
                     /gene_functions="transport (smcogs) SMCOG1000:ABC
                     transporter ATP-binding protein (Score: 185; E-value:
                     2.9e-56)"
                     /gene_kind="transport"
                     /locus_tag="ctg1_2431"
                     /transl_table=11
                     /translation="VLHNLSLQVEKAEIFGLVGPSGSGKTTLIKLIAGINEATEGEVLV
                     YNTNMPNLNEMKRIGYMAQADALYEELSAYENADFMATMYGLKGKHKKERIEKVFDLVQ
                     LSQHMKKQVQHFSGGMKKRLSLAIALLHEPEILILDEPTVGIDPLLRKTIWEKFYDLKK
                     KGTTIIVTTHIMDEAEFCERLGLIREGKLVATGTTEELKKRVSSGRIEDVFLLEEVAEL
                     "
     PFAM_domain     3041..3466
                     /aSDomain="ABC_tran"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00005.29"
                     /description="ABC transporter"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_2431_0086"
                     /evalue="7.70E-32"
                     /label="ctg1_2431"
                     /locus_tag="ctg1_2431"
                     /protein_end="143"
                     /protein_start="1"
                     /score="110.8"
                     /tool="antismash"
                     /translation="LHNLSLQVEKAEIFGLVGPSGSGKTTLIKLIAGINEATEGEVLVY
                     NTNMPNLNEMKRIGYMAQADALYEELSAYENADFMATMYGLKGKHKKERIEKVFDLVQL
                     SQHMKKQVQHFSGGMKKRLSLAIALLHEPEILILDEPT"
     CDS             3703..4722
                     /gene_functions="transport (smcogs) SMCOG1065:ABC-2 type
                     transporter (Score: 72.7; E-value: 4.3e-22)"
                     /gene_kind="transport"
                     /locus_tag="ctg1_2432"
                     /transl_table=11
                     /translation="MRVTGVIIRIIRQFFRDKRSLAMMFGAPMLLLWLLSLVFTQKDYV
                     PHIAVVDMPAQLVKVMKNQEASIYEYNTEKAMSELENQKVDAVIRLENGKMNIVLEGSD
                     SSKNRAVLQILQKSTEKNDISIMKPEVNYLHGSKDFTMFDGLGPVLIGFFTFFFVFILS
                     GVSFVRERLSGALERLLSTPIKRWEIVVGYIIGFGIFAFIQSIIIVSFSVYILDLYVAG
                     SIWLTLLITCMLSLTALTLGTFLSAYANNEFQMIQFIPLVIVPQIFFSGLFPIESMNKW
                     LQMLGKLFPLTYGADAMRQVMIRNQGFTEIALDLTVLLFFSVLFAVGNVFALKKHRKI"
     PFAM_domain     4129..4608
                     /aSDomain="ABC2_membrane"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF01061.26"
                     /description="ABC-2 type transporter"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_2432_0087"
                     /evalue="3.00E-34"
                     /label="ctg1_2432"
                     /locus_tag="ctg1_2432"
                     /protein_end="302"
                     /protein_start="142"
                     /score="118.4"
                     /tool="antismash"
                     /translation="FDGLGPVLIGFFTFFFVFILSGVSFVRERLSGALERLLSTPIKRW
                     EIVVGYIIGFGIFAFIQSIIIVSFSVYILDLYVAGSIWLTLLITCMLSLTALTLGTFLS
                     AYANNEFQMIQFIPLVIVPQIFFSGLFPIESMNKWLQMLGKLFPLTYGADAMRQVM"
     CDS             4762..5400
                     /gene_functions="regulatory (smcogs) SMCOG1057:TetR family
                     transcriptional regulator (Score: 97.1; E-value: 2.9e-29)"
                     /gene_kind="regulatory"
                     /locus_tag="ctg1_2433"
                     /transl_table=11
                     /translation="LEELIAATNTDKRNERQMRILEAAVDMFGEKGYASTSTSEIAKRA
                     GVAEGTIFRYYKTKKDLLLAVVMPTLMKFAAPFFVQAFAKEIFKSEYESYEGLLRVVIH
                     NRFDFAKKHFPMIKILIQEVPFHPELKNEIQQLVETELLLHFKKLIEKFQEKGKIIEMP
                     PATVLRLTLSAVFGLLLTRFLLLPEEKWDDETEIENTIQFILYGLTPRN"
     PFAM_domain     4819..4959
                     /aSDomain="TetR_N"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00440.25"
                     /description="Bacterial regulatory proteins, tetR family"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_2433_0088"
                     /evalue="1.60E-18"
                     /label="ctg1_2433"
                     /locus_tag="ctg1_2433"
                     /protein_end="66"
                     /protein_start="19"
                     /score="66.3"
                     /tool="antismash"
                     /translation="ILEAAVDMFGEKGYASTSTSEIAKRAGVAEGTIFRYYKTKKDLLL
                     AV"
     CDS             complement(5522..5821)
                     /locus_tag="ctg1_2434"
                     /transl_table=11
                     /translation="MKKKLSSIVSVLALSIMFLGTSAHAEYDGTNMNRVNNTDISTRVN
                     DNNLDRVNNDVRTRNVNTTNDLNDNRDRNNNWAWLGLLGLAGLLGLRRRDKEVR"
     CDS             6054..7022
                     /locus_tag="ctg1_2435"
                     /transl_table=11
                     /translation="MRQFAKPTIVVSKCLEFDACRYNGEMIPDVTIRNLQPFVTFIPVC
                     PEVEIGLGTPRETIRIVEEKGVNKLVQPSTREDLTEKMEQFSNEFLQTLSDVDGFILKN
                     RSPSCGTRDVKIYSGFEKAPAKGKGPGLFGGAVVKKFSHLPIEEEGRLSNFIIREHFFT
                     RLFTIAYYKMIKRNKNMKDLVSFQSDNKYLFMAYNQVKQKELGRIIANQKNETIEVVFE
                     NYEKTLYELFMRTPRYTSNVNVCEHIFGYFKTKLKKQEKDHFLNLIQKYIEKKIPLSSL
                     LAILKSWALRFDEKYLLRQTYFEPYPEALVEISDSGKGRDY"
     PFAM_domain     6078..6500
                     /aSDomain="2-thiour_desulf"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF04463.14"
                     /description="2-thiouracil desulfurase"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_2435_0089"
                     /evalue="7.90E-36"
                     /label="ctg1_2435"
                     /locus_tag="ctg1_2435"
                     /protein_end="149"
                     /protein_start="8"
                     /score="123.2"
                     /tool="antismash"
                     /translation="IVVSKCLEFDACRYNGEMIPDVTIRNLQPFVTFIPVCPEVEIGLG
                     TPRETIRIVEEKGVNKLVQPSTREDLTEKMEQFSNEFLQTLSDVDGFILKNRSPSCGTR
                     DVKIYSGFEKAPAKGKGPGLFGGAVVKKFSHLPIEEE"
     PFAM_domain     6624..6974
                     /aSDomain="DUF1722"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF08349.13"
                     /description="Protein of unknown function (DUF1722)"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_2435_0090"
                     /evalue="2.50E-40"
                     /label="ctg1_2435"
                     /locus_tag="ctg1_2435"
                     /protein_end="307"
                     /protein_start="190"
                     /score="137.5"
                     /tool="antismash"
                     /translation="KYLFMAYNQVKQKELGRIIANQKNETIEVVFENYEKTLYELFMRT
                     PRYTSNVNVCEHIFGYFKTKLKKQEKDHFLNLIQKYIEKKIPLSSLLAILKSWALRFDE
                     KYLLRQTYFEPYP"
     CDS             7239..8384
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Acyl-CoA_dh_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Acyl-CoA_dh_M"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Acyl-CoA_dh_1"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1006:acyl-CoA dehydrogenase (Score: 447.1; E-value:
                     8.6e-136)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg1_2436"
                     /sec_met_domain="Acyl-CoA_dh_N (E-value: 1.8e-39, bitscore:
                     133.2, seeds: 790, tool: rule-based-clusters)"
                     /sec_met_domain="Acyl-CoA_dh_M (E-value: 6.2e-26, bitscore:
                     88.8, seeds: 43, tool: rule-based-clusters)"
                     /sec_met_domain="Acyl-CoA_dh_1 (E-value: 1.5e-56, bitscore:
                     189.1, seeds: 49, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MEFTLTREKQMIKEMVRDFAEKEIAPKAVYYDKTAEFPYETFQKM
                     GELGLLGIPFPEEYGGSGGDTVSYALAVEEIGRACGGTGLSYAATISLGASPIYYFGTE
                     EQKQKYLVPMASGKTLGAFGLTEPNAGSDAGGTQTKAILDGDEYVISGEKCWITNAEYA
                     NTIIVTAVNGIEENGRKRISAFIVPTTSEGLTISSPYDKMGVRASNTCEIVLDGVRVPK
                     ENILGDVNKGFKQFLYTLDGGRISIAVLAVGIAQSAFERALQYAKERQQFGKAISNFQA
                     IQFKLADMATEVELARNLVHKAAWLKDNDKPFGKEAAMAKLFASEAASRIANQAVQIHG
                     GYGYMREYEVERHIRDAKLLEIGEGTSEIQRLVIARHLGCR"
     PFAM_domain     7254..7592
                     /aSDomain="Acyl-CoA_dh_N"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF02771.18"
                     /description="Acyl-CoA dehydrogenase, N-terminal domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_2436_0091"
                     /evalue="2.00E-39"
                     /label="ctg1_2436"
                     /locus_tag="ctg1_2436"
                     /protein_end="118"
                     /protein_start="5"
                     /score="134.8"
                     /tool="antismash"
                     /translation="TREKQMIKEMVRDFAEKEIAPKAVYYDKTAEFPYETFQKMGELGL
                     LGIPFPEEYGGSGGDTVSYALAVEEIGRACGGTGLSYAATISLGASPIYYFGTEEQKQK
                     YLVPMASGK"
     PFAM_domain     7602..7892
                     /aSDomain="Acyl-CoA_dh_M"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF02770.21"
                     /description="Acyl-CoA dehydrogenase, middle domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_2436_0092"
                     /evalue="2.60E-26"
                     /label="ctg1_2436"
                     /locus_tag="ctg1_2436"
                     /protein_end="218"
                     /protein_start="121"
                     /score="91.7"
                     /tool="antismash"
                     /translation="AFGLTEPNAGSDAGGTQTKAILDGDEYVISGEKCWITNAEYANTI
                     IVTAVNGIEENGRKRISAFIVPTTSEGLTISSPYDKMGVRASNTCEIVLDGV"
     PFAM_domain     7926..8372
                     /aSDomain="Acyl-CoA_dh_1"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00441.26"
                     /description="Acyl-CoA dehydrogenase, C-terminal domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_2436_0093"
                     /evalue="5.40E-56"
                     /label="ctg1_2436"
                     /locus_tag="ctg1_2436"
                     /protein_end="378"
                     /protein_start="229"
                     /score="189.1"
                     /tool="antismash"
                     /translation="NKGFKQFLYTLDGGRISIAVLAVGIAQSAFERALQYAKERQQFGK
                     AISNFQAIQFKLADMATEVELARNLVHKAAWLKDNDKPFGKEAAMAKLFASEAASRIAN
                     QAVQIHGGYGYMREYEVERHIRDAKLLEIGEGTSEIQRLVIARHL"
     PFAM_domain     8400..8729
                     /aSDomain="Biotin_carb_N"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00289.24"
                     /description="Biotin carboxylase, N-terminal domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_2437_0094"
                     /evalue="4.00E-45"
                     /label="ctg1_2437"
                     /locus_tag="ctg1_2437"
                     /protein_end="110"
                     /protein_start="0"
                     /score="153.0"
                     /tool="antismash"
                     /translation="MFQKILIANRGEIAVRIMKTCQKLGIRTVAIYSEADENALHVKMA
                     NEAYLVGGPRVQESYLNLEKIIEIAKKTNAEAIHPGYGLLSENPSFPVRCKEEGIVFIG
                     PSEEII"
     CDS             8400..9737
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) RimK"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ATP-grasp"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1090:acetyl-CoA carboxylase biotin carboxylase (Score:
                     645.5; E-value: 1.8e-195)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg1_2437"
                     /sec_met_domain="RimK (E-value: 1.1e-06, bitscore: 26.7,
                     seeds: 4, tool: rule-based-clusters)"
                     /sec_met_domain="ATP-grasp (E-value: 2.4e-09, bitscore:
                     35.3, seeds: 20, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MFQKILIANRGEIAVRIMKTCQKLGIRTVAIYSEADENALHVKMA
                     NEAYLVGGPRVQESYLNLEKIIEIAKKTNAEAIHPGYGLLSENPSFPVRCKEEGIVFIG
                     PSEEIITKMGSKIESRIAMQAADVPVVPGITTNIETAEEAIEIAKQIGYPLMLKASAGG
                     GGIGMQLMETEQTLTKAFESNKTRAQNFFGNGEMYLERYIADAHHIEIQLLADTHGNTV
                     YLWERECSVQRRNQKVIEEAPSPFLDEGTRKAMGEIAVQAAKALGYTNAGTVEFLVDEQ
                     KNFYFLEMNTRLQVEHPVTEEITGLDLVEQQLLIAYGEKLSFTQDDIKRSGHAIEARIY
                     AEDPKTFFPSPGKITDLTLPTNVRIDHFLENQVTITPFYDPMIAKVIAHGETREEAISK
                     LHDALEELKVEGIKTNTPMLLQVLEDDVFKSGIYTTGFVTKQLVKK"
     PFAM_domain     8745..9365
                     /aSDomain="CPSase_L_D2"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF02786.19"
                     /description="Carbamoyl-phosphate synthase L chain, ATP
                     binding domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_2437_0095"
                     /evalue="4.00E-75"
                     /label="ctg1_2437"
                     /locus_tag="ctg1_2437"
                     /protein_end="322"
                     /protein_start="115"
                     /score="252.0"
                     /tool="antismash"
                     /translation="KIESRIAMQAADVPVVPGITTNIETAEEAIEIAKQIGYPLMLKAS
                     AGGGGIGMQLMETEQTLTKAFESNKTRAQNFFGNGEMYLERYIADAHHIEIQLLADTHG
                     NTVYLWERECSVQRRNQKVIEEAPSPFLDEGTRKAMGEIAVQAAKALGYTNAGTVEFLV
                     DEQKNFYFLEMNTRLQVEHPVTEEITGLDLVEQQLLIAYGEKLS"
     PFAM_domain     9405..9716
                     /aSDomain="Biotin_carb_C"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF02785.21"
                     /description="Biotin carboxylase C-terminal domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_2437_0096"
                     /evalue="1.10E-34"
                     /label="ctg1_2437"
                     /locus_tag="ctg1_2437"
                     /protein_end="439"
                     /protein_start="335"
                     /score="118.8"
                     /tool="antismash"
                     /translation="EARIYAEDPKTFFPSPGKITDLTLPTNVRIDHFLENQVTITPFYD
                     PMIAKVIAHGETREEAISKLHDALEELKVEGIKTNTPMLLQVLEDDVFKSGIYTTGFVT
                     "
     CDS             9764..9979
                     /locus_tag="ctg1_2438"
                     /transl_table=11
                     /translation="MMTKVYASMAGNVWKIVVGVGDTVEEEQDVVILESMKMEIPIVSE
                     EAGTVMKINVQEGDFVNEGDVLLEIE"
     PFAM_domain     9785..9973
                     /aSDomain="Biotin_lipoyl"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00364.24"
                     /description="Biotin-requiring enzyme"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_2438_0097"
                     /evalue="2.30E-17"
                     /label="ctg1_2438"
                     /locus_tag="ctg1_2438"
                     /protein_end="70"
                     /protein_start="7"
                     /score="62.7"
                     /tool="antismash"
                     /translation="SMAGNVWKIVVGVGDTVEEEQDVVILESMKMEIPIVSEEAGTVMK
                     INVQEGDFVNEGDVLLEI"
     CDS             10001..10912
                     /gene_functions="biosynthetic (rule-based-clusters)
                     betalactone: HMGL-like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1271:2-isopropylmalate synthase (Score: 217.9;
                     E-value: 4.4e-66)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg1_2439"
                     /sec_met_domain="HMGL-like (E-value: 6.5e-47, bitscore:
                     158.6, seeds: 15, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="LKLPNFAVIKEVGPRDGLQNEKKIVGTKDKVKWIQLLTEAGLSYV
                     EVSSFVHPKWVPALADANDVFSELKRDPNVTYAALVPNQNGLERAFLQNVDEVNVFLSA
                     SESHNKSNINKSIKEALVVIEDITKQALFEGKKVRGYVSTVFGCPYEGDISAIAVDELC
                     DQLFSYGIYEVSLGDTIGVANPLQVERVLEHLLKKYDASQFAMHFHNTYGMALANVVKS
                     LEYGITTFDSSCGGLGGCPYAPGASGNVATDDLVHMLHKLGVQTNIDEEKLLRASQFIQ
                     SKLNIQLPSHVYRALQHKTISR"
     PFAM_domain     10025..10840
                     /aSDomain="HMGL-like"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00682.21"
                     /description="HMGL-like"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_2439_0098"
                     /evalue="2.10E-47"
                     /label="ctg1_2439"
                     /locus_tag="ctg1_2439"
                     /protein_end="280"
                     /protein_start="8"
                     /score="162.0"
                     /tool="antismash"
                     /translation="IKEVGPRDGLQNEKKIVGTKDKVKWIQLLTEAGLSYVEVSSFVHP
                     KWVPALADANDVFSELKRDPNVTYAALVPNQNGLERAFLQNVDEVNVFLSASESHNKSN
                     INKSIKEALVVIEDITKQALFEGKKVRGYVSTVFGCPYEGDISAIAVDELCDQLFSYGI
                     YEVSLGDTIGVANPLQVERVLEHLLKKYDASQFAMHFHNTYGMALANVVKSLEYGITTF
                     DSSCGGLGGCPYAPGASGNVATDDLVHMLHKLGVQTNIDEEKLLRASQFI"
     CDS             10917..11705
                     /NRPS_PKS="Domain: ECH (14-254). E-value: 2e-74. Score:
                     241.8. Matches aSDomain: nrpspksdomains_ctg1_2440_ECH.1"
                     /NRPS_PKS="type: other"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1023:enoyl-CoA hydratase (Score: 254; E-value:
                     1.9e-77)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg1_2440"
                     /transl_table=11
                     /translation="MLQLQNISVDYATPHVVKISLNRERQANSLSLALLEELQNILTQI
                     NEEANTRVVILTGAGEKAFCAGADLKERAGMNEEQVRHAVSMIRTTMEMVEQLPQPVIA
                     AINGIALGGGTELSLACDFRIAAESASLGLTETTLAIIPGAGGTQRLPRLIGVGRAKEL
                     IYTGRRISAQEAKEYGLVEFVVPVHLLEEKAIEIAEKIASNGPIAVRLAKEAISNGIQV
                     DLHTGLQMEKQAYEGVIHTKDRLEGLQAFKEKRTPMYKGE"
     aSDomain        10959..11678
                     /aSDomain="ECH"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg1_2440_ECH.1"
                     /evalue="2.00E-74"
                     /label="ctg1_2440_ECH.1"
                     /locus_tag="ctg1_2440"
                     /protein_end="254"
                     /protein_start="14"
                     /score="241.8"
                     /tool="antismash"
                     /translation="HVVKISLNRERQANSLSLALLEELQNILTQINEEANTRVVILTGA
                     GEKAFCAGADLKERAGMNEEQVRHAVSMIRTTMEMVEQLPQPVIAAINGIALGGGTELS
                     LACDFRIAAESASLGLTETTLAIIPGAGGTQRLPRLIGVGRAKELIYTGRRISAQEAKE
                     YGLVEFVVPVHLLEEKAIEIAEKIASNGPIAVRLAKEAISNGIQVDLHTGLQMEKQAYE
                     GVIHTKDRLEGLQAFKEK"
     PFAM_domain     10962..11699
                     /aSDomain="ECH_1"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00378.22"
                     /description="Enoyl-CoA hydratase/isomerase"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_2440_0099"
                     /evalue="7.30E-71"
                     /label="ctg1_2440"
                     /locus_tag="ctg1_2440"
                     /protein_end="261"
                     /protein_start="15"
                     /score="238.5"
                     /tool="antismash"
                     /translation="VVKISLNRERQANSLSLALLEELQNILTQINEEANTRVVILTGAG
                     EKAFCAGADLKERAGMNEEQVRHAVSMIRTTMEMVEQLPQPVIAAINGIALGGGTELSL
                     ACDFRIAAESASLGLTETTLAIIPGAGGTQRLPRLIGVGRAKELIYTGRRISAQEAKEY
                     GLVEFVVPVHLLEEKAIEIAEKIASNGPIAVRLAKEAISNGIQVDLHTGLQMEKQAYEG
                     VIHTKDRLEGLQAFKEKRTPMYKG"
     CDS             11708..13249
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1059:acetyl-CoA carboxylase, carboxyl transferase,
                     (Score: 520; E-value: 1.3e-157)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg1_2441"
                     /transl_table=11
                     /translation="MIDQKQQSNTFEERVETIKRGGAPKYHEQNKAKGKLFVRDRLALL
                     FDNGEYVEDALFANCEETGLPADGVITATGKIHGRTACVMANDSTVKAGSWGARTVEKI
                     LRIQETAEKLRVPLFYLVDSAGARITDQVEMFPGRRGAGRIFYNQVKLSGKVPQVCLLF
                     GPSAAGGAYIPAFCDVVMMVEGNASMYLGSPRMAEMVIGEKVTLEEMGGARMHCSISGC
                     GDVLCKTEEDAITQARQYISYFPNNYLEKTPLVTPQEPKQFDKTLEQIIPENQNAPFNM
                     KDLINRVIDEGSFYEVKKLFAQELITGLARIDGKPVGIIANQPRMKGGVLFHDSADKAA
                     KFINLCDAYHIPLLFLADVPGFMIGTKVERAGIIRHGAKMISAMSEATVPKISIVVRKA
                     YGAGLYAMAGPAFEPDCCLALPTASIAVMGPEAAVNAVYANKIAALPEEERDSFIAEKR
                     EEYKKDIDIYHLASEMVIDGIVHPNNLREELKGRFEMYMSKYQVFTDRKHPVYPV"
     PFAM_domain     11795..13237
                     /aSDomain="Carboxyl_trans"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF01039.24"
                     /description="Carboxyl transferase domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_2441_0100"
                     /evalue="1.10E-158"
                     /label="ctg1_2441"
                     /locus_tag="ctg1_2441"
                     /protein_end="510"
                     /protein_start="29"
                     /score="529.1"
                     /tool="antismash"
                     /translation="NKAKGKLFVRDRLALLFDNGEYVEDALFANCEETGLPADGVITAT
                     GKIHGRTACVMANDSTVKAGSWGARTVEKILRIQETAEKLRVPLFYLVDSAGARITDQV
                     EMFPGRRGAGRIFYNQVKLSGKVPQVCLLFGPSAAGGAYIPAFCDVVMMVEGNASMYLG
                     SPRMAEMVIGEKVTLEEMGGARMHCSISGCGDVLCKTEEDAITQARQYISYFPNNYLEK
                     TPLVTPQEPKQFDKTLEQIIPENQNAPFNMKDLINRVIDEGSFYEVKKLFAQELITGLA
                     RIDGKPVGIIANQPRMKGGVLFHDSADKAAKFINLCDAYHIPLLFLADVPGFMIGTKVE
                     RAGIIRHGAKMISAMSEATVPKISIVVRKAYGAGLYAMAGPAFEPDCCLALPTASIAVM
                     GPEAAVNAVYANKIAALPEEERDSFIAEKREEYKKDIDIYHLASEMVIDGIVHPNNLRE
                     ELKGRFEMYMSKYQVFTDRKHPV"
     CDS             13299..15239
                     /NRPS_PKS="Domain: AMP-binding (97-521). E-value: 6e-82.
                     Score: 267.2. Matches aSDomain:
                     nrpspksdomains_ctg1_2442_AMP-binding.1"
                     /NRPS_PKS="type: NRPS-like protein"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     betalactone: AMP-binding"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1002:AMP-dependent synthetase and ligase (Score: 260;
                     E-value: 5.7e-79)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg1_2442"
                     /sec_met_domain="AMP-binding (E-value: 1e-87, bitscore:
                     292.7, seeds: 400, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="LKQAVWFPTEEYKEKTRLYGWMKSLGYEDYETFYNKSIEETAWFW
                     GEAEKVVGYQWMKPYTEVLDLQNGTPFAQWYNGGTCNVVESVLSRWLADDETRTQPALQ
                     YEGENGTSKSFTYEELDSWVSRAANGLKHAGIEKGDRVTIYMPMIPETVVAMLAVMKIG
                     AIISPIFSGFASDAVMTRVQAAGSKMIITADGFSRRGKIVSLKDEVDKACEHCPTVEKV
                     VIVRHAGNDFTPHNYDFSWSTLEKEKPFVHAEEMHSDDPLMLIYTSGTTGKPKGTVHTH
                     AGFPLKAAFDAGFGMNIKQGDRVLWVTDMGWMMGPFLLFGSLINGATMVMYEGVPDFPK
                     ADRLWETVDKYEITHLGISPTLIRALMAKGDEYVNKHSLKSLEVFASTGEPWNPDPWMW
                     LFETVGKSNVPICNYSGGTEISGGIFGNVLIKPIAPISFNASLPGMAAVVLDDQGNPIR
                     DEVGELCLEKPWVGMTKSFWEDDERYVNTYWSRFENKWVHGDWVVYDGEQYIITGRSDD
                     TLNIAGKRIGPAEYESILVKHNDVIEAAAIGVPDDVKGEVCHCFVVLRDNVTFTGELKK
                     ELMSLVNSHIGKALCPKDIHVVEDLPKTRNSKVMRRVIKAAYLGKELGDLSSLVNPEVV
                     PFIQGLQSSKL"
     PFAM_domain     13386..13553
                     /aSDomain="ACAS_N"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF16177.7"
                     /description="Acetyl-coenzyme A synthetase N-terminus"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_2442_0101"
                     /evalue="4.00E-12"
                     /label="ctg1_2442"
                     /locus_tag="ctg1_2442"
                     /protein_end="85"
                     /protein_start="29"
                     /score="46.0"
                     /tool="antismash"
                     /translation="YETFYNKSIEETAWFWGEAEKVVGYQWMKPYTEVLDLQNGTPFAQ
                     WYNGGTCNVVE"
     PFAM_domain     13587..14861
                     /aSDomain="AMP-binding"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00501.30"
                     /description="AMP-binding enzyme"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_2442_0102"
                     /evalue="2.50E-76"
                     /label="ctg1_2442"
                     /locus_tag="ctg1_2442"
                     /protein_end="521"
                     /protein_start="96"
                     /score="257.1"
                     /tool="antismash"
                     /translation="TRTQPALQYEGENGTSKSFTYEELDSWVSRAANGLKHAGIEKGDR
                     VTIYMPMIPETVVAMLAVMKIGAIISPIFSGFASDAVMTRVQAAGSKMIITADGFSRRG
                     KIVSLKDEVDKACEHCPTVEKVVIVRHAGNDFTPHNYDFSWSTLEKEKPFVHAEEMHSD
                     DPLMLIYTSGTTGKPKGTVHTHAGFPLKAAFDAGFGMNIKQGDRVLWVTDMGWMMGPFL
                     LFGSLINGATMVMYEGVPDFPKADRLWETVDKYEITHLGISPTLIRALMAKGDEYVNKH
                     SLKSLEVFASTGEPWNPDPWMWLFETVGKSNVPICNYSGGTEISGGIFGNVLIKPIAPI
                     SFNASLPGMAAVVLDDQGNPIRDEVGELCLEKPWVGMTKSFWEDDERYVNTYWSRFENK
                     WVHGDWVVYDGEQYIITGRSDDTLNI"
     aSDomain        13590..14861
                     /aSDomain="AMP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg1_2442_AMP-binding.1"
                     /evalue="6.00E-82"
                     /label="ctg1_2442_AMP-binding.1"
                     /locus_tag="ctg1_2442"
                     /protein_end="521"
                     /protein_start="97"
                     /score="267.2"
                     /specificity="consensus: X"
                     /tool="antismash"
                     /translation="RTQPALQYEGENGTSKSFTYEELDSWVSRAANGLKHAGIEKGDRV
                     TIYMPMIPETVVAMLAVMKIGAIISPIFSGFASDAVMTRVQAAGSKMIITADGFSRRGK
                     IVSLKDEVDKACEHCPTVEKVVIVRHAGNDFTPHNYDFSWSTLEKEKPFVHAEEMHSDD
                     PLMLIYTSGTTGKPKGTVHTHAGFPLKAAFDAGFGMNIKQGDRVLWVTDMGWMMGPFLL
                     FGSLINGATMVMYEGVPDFPKADRLWETVDKYEITHLGISPTLIRALMAKGDEYVNKHS
                     LKSLEVFASTGEPWNPDPWMWLFETVGKSNVPICNYSGGTEISGGIFGNVLIKPIAPIS
                     FNASLPGMAAVVLDDQGNPIRDEVGELCLEKPWVGMTKSFWEDDERYVNTYWSRFENKW
                     VHGDWVVYDGEQYIITGRSDDTLNI"
     CDS_motif       14085..14141
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ctg1_2442_0001"
                     /evalue="7.60E-08"
                     /label="NRPS-A_a3"
                     /locus_tag="ctg1_2442"
                     /protein_end="281"
                     /protein_start="262"
                     /score="24.7"
                     /tool="antismash"
                     /translation="MLIYTSGTTGKPKGTVHTH"
     CDS_motif       14832..14894
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ctg1_2442_0002"
                     /evalue="7.80E-04"
                     /label="NRPS-A_a8"
                     /locus_tag="ctg1_2442"
                     /protein_end="532"
                     /protein_start="511"
                     /score="12.3"
                     /tool="antismash"
                     /translation="TGRSDDTLNIAGKRIGPAEYE"
     PFAM_domain     14886..15122
                     /aSDomain="AMP-binding_C"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF13193.8"
                     /description="AMP-binding enzyme C-terminal domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_2442_0103"
                     /evalue="1.40E-21"
                     /label="ctg1_2442"
                     /locus_tag="ctg1_2442"
                     /protein_end="608"
                     /protein_start="529"
                     /score="77.4"
                     /tool="antismash"
                     /translation="EYESILVKHNDVIEAAAIGVPDDVKGEVCHCFVVLRDNVTFTGEL
                     KKELMSLVNSHIGKALCPKDIHVVEDLPKTRNSK"
     CDS             15409..15738
                     /locus_tag="ctg1_2443"
                     /transl_table=11
                     /translation="LGSRYSNSRKKCSCKQCSCKQDDCWDVFEECKKEHEEQNKACDCC
                     CVQGIRDELRKLVNRSVRITTGSNNYAGTVSSVTCDVVKLANSAGVVTVIISVCKIEAI
                     EALLT"
     CDS             15859..16401
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1111:GCN5-related N-acetyltransferase (Score: 74.4;
                     E-value: 1.7e-22)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg1_2444"
                     /transl_table=11
                     /translation="MVYERRMKLIKLEPFKRSDFKRLINWIDSEEFLIQWSGNAFTYPL
                     HEQQLEKYIESENTLAFKVIDEETKEVIGHISLGQIDHINKSARIGKVLVGDTRMRGRS
                     IGKHMMKAVLHIAFDELKLHRVTLGVYDFNTSAISCYEKIGFVKEGLLRESKKVGETYW
                     NLWEMSMLEYEWGDKKQ"
     PFAM_domain     15958..16296
                     /aSDomain="Acetyltransf_1"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00583.27"
                     /description="Acetyltransferase (GNAT) family"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_2444_0104"
                     /evalue="1.80E-13"
                     /label="ctg1_2444"
                     /locus_tag="ctg1_2444"
                     /protein_end="146"
                     /protein_start="33"
                     /score="50.8"
                     /tool="antismash"
                     /translation="IQWSGNAFTYPLHEQQLEKYIESENTLAFKVIDEETKEVIGHISL
                     GQIDHINKSARIGKVLVGDTRMRGRSIGKHMMKAVLHIAFDELKLHRVTLGVYDFNTSA
                     ISCYEKIGF"
     CDS             16450..17010
                     /locus_tag="ctg1_2445"
                     /transl_table=11
                     /translation="MNKKTKIITIAAVSGGGKTTVTERLTHKLMNSKALYFDRYNFDNC
                     PTDICKWIDDGANYDEWVLTPLIKDIQHLIRDSNVDYIIVDYPFAYLNSEMRQFIDVTI
                     FIDTPLDIAMARRILRDFKEDTISEIHNDLEHYINYARKAYLEALHTVKPNSDIVLDGA
                     LSVDQIINQIEEELYRREVIANG"
     CDS             17003..17743
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Abhydrolase_6"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF00561"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1262:haloalkane dehalogenase (Score: 44.2; E-value:
                     2.3e-13)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg1_2446"
                     /sec_met_domain="Abhydrolase_6 (E-value: 8.9e-08, bitscore:
                     31.3, seeds: 455, tool: rule-based-clusters)"
                     /sec_met_domain="PF00561 (E-value: 2.3e-11, bitscore: 42.2,
                     seeds: 48, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MVKSIEKYVQVDDFKIYSKVFQGKKLQPVIIMEAGYGDYSKAWDL
                     IAEELTEYGTVLTYDRAGVGKSGKSSKRRISSEMIKDLRSCLEQLQLKPPYIFVGHSFG
                     GINARLFANFYPEDMSGIVLVDSTPENYKEDFLPIMSLEFQEAYYKQFVYESSYEEFMF
                     SLSEANKHCQSMRNIPLAVLVTGKKAYYSQEAQMKWLQLQEELLRLSNNHTFVIAEQSG
                     HYIQKDEPHYIIDAVKWIIEVEER"
     PFAM_domain     17084..17377
                     /aSDomain="Hydrolase_4"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF12146.10"
                     /description="Serine aminopeptidase, S33"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_2446_0105"
                     /evalue="3.60E-12"
                     /label="ctg1_2446"
                     /locus_tag="ctg1_2446"
                     /protein_end="125"
                     /protein_start="27"
                     /score="46.1"
                     /tool="antismash"
                     /translation="PVIIMEAGYGDYSKAWDLIAEELTEYGTVLTYDRAGVGKSGKSSK
                     RRISSEMIKDLRSCLEQLQLKPPYIFVGHSFGGINARLFANFYPEDMSGIVLV"
     CDS             17746..18204
                     /locus_tag="ctg1_2447"
                     /transl_table=11
                     /translation="VYTLFQYNWQVRDDWFKWCEQLSKEELLRKRIGGVGSILETLFHI
                     VDVEYSWINALQEKEDCVPQFKEYQSIQKVKALSNLYKRELEDFLQVWSANLECKILKA
                     SWTDKTYTYGEVLRHVIVHEIHHIGQLSIWARELNLRPVSANLIGRGL"
     PFAM_domain     17752..18177
                     /aSDomain="DinB"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF05163.14"
                     /description="DinB family"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_2447_0106"
                     /evalue="2.80E-31"
                     /label="ctg1_2447"
                     /locus_tag="ctg1_2447"
                     /protein_end="144"
                     /protein_start="2"
                     /score="108.7"
                     /tool="antismash"
                     /translation="TLFQYNWQVRDDWFKWCEQLSKEELLRKRIGGVGSILETLFHIVD
                     VEYSWINALQEKEDCVPQFKEYQSIQKVKALSNLYKRELEDFLQVWSANLECKILKASW
                     TDKTYTYGEVLRHVIVHEIHHIGQLSIWARELNLRPVS"
     CDS             complement(18263..19279)
                     /locus_tag="ctg1_2448"
                     /transl_table=11
                     /translation="MQFLKKITILLLSFVITALIVLYFYLYVNGPIIQAKSAILIDANS
                     GEVVYKKNEENSIQSATLSKLMTEYIVLEQLDKGNIQLDEVVKISNEVFRAETSPIQVT
                     SKDKTTVRDLLHALLLTGNNRSTLALAEHIAGNEDNFTQLMNEKAKQLKLSQPSPFLNA
                     TGMNNGTNKLSTTTAIEVGKLATRLVTDFPDVLNVTKLTSYQFTFKDTKVFNTNKMIYS
                     LNKNIKLQGVDGLQTSFSTNSNYSFVSTAKRGDTRLISVILDADNENSTFIETKKLLQY
                     GFDPSSYSALQAFKDAVTSWAVLLQFKNLIIQTLLIFFIITILMLLHIRQKKSEDFN"
     PFAM_domain     complement(18482..19189)
                     /aSDomain="Peptidase_S11"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00768.22"
                     /description="D-alanyl-D-alanine carboxypeptidase"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_2448_0107"
                     /evalue="4.00E-53"
                     /label="ctg1_2448"
                     /locus_tag="ctg1_2448"
                     /protein_end="266"
                     /protein_start="30"
                     /score="180.4"
                     /tool="antismash"
                     /translation="PIIQAKSAILIDANSGEVVYKKNEENSIQSATLSKLMTEYIVLEQ
                     LDKGNIQLDEVVKISNEVFRAETSPIQVTSKDKTTVRDLLHALLLTGNNRSTLALAEHI
                     AGNEDNFTQLMNEKAKQLKLSQPSPFLNATGMNNGTNKLSTTTAIEVGKLATRLVTDFP
                     DVLNVTKLTSYQFTFKDTKVFNTNKMIYSLNKNIKLQGVDGLQTSFSTNSNYSFVSTAK
                     RGDTRLISVILDAD"
     CDS             complement(19461..20618)
                     /gene_functions="resistance (resist) vanS (Score: 271.7;
                     E-value: 6e-83)"
                     /gene_functions="regulatory (smcogs) SMCOG1003:sensor
                     histidine kinase (Score: 211.1; E-value: 6.7e-64)"
                     /gene_kind="regulatory"
                     /locus_tag="ctg1_2449"
                     /transl_table=11
                     /translation="LRNEAFDILKDIPKWKLIFWLLLAITLTPITELIIYRLVTSVIES
                     SLTLSELGKEFIRIFGYEKYKGIKESLWMMIVSYLFLFSIFSSYLYIFYRHERKLYYET
                     CIKKMIEEIRYIANGNFNHKVSIVNHNYLEELASGVNQIVEQLKVSIDEERQAEQAKSE
                     LITNVSHDLRTPLTSIVGYVNLIHHDNYRDEVELRHYIQVIYDKVTRLNALMNDLFEYT
                     RVQNKELSLYSVPIDIVELLGQLTVQFRIQLQEANIDCRPFFPSKKLMVLADGDKLVRV
                     FENLIINAIAYGNDGDYIDITAYENNNMIAIDITNYGQPIPSTDLPHIFERFYRVEKSR
                     STNTGGSGLGLAIAKSIVELHKGTIEVYSDDKKTTFTVKLQPYKC"
     PFAM_domain     complement(19473..19799)
                     /aSDomain="HATPase_c"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF02518.28"
                     /description="Histidine kinase-, DNA gyrase B-, and
                     HSP90-like ATPase"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_2449_0109"
                     /evalue="2.10E-21"
                     /label="ctg1_2449"
                     /locus_tag="ctg1_2449"
                     /protein_end="382"
                     /protein_start="273"
                     /score="76.6"
                     /tool="antismash"
                     /translation="DGDKLVRVFENLIINAIAYGNDGDYIDITAYENNNMIAIDITNYG
                     QPIPSTDLPHIFERFYRVEKSRSTNTGGSGLGLAIAKSIVELHKGTIEVYSDDKKTTFT
                     VKLQP"
     PFAM_domain     complement(19944..20141)
                     /aSDomain="HisKA"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00512.27"
                     /description="His Kinase A (phospho-acceptor) domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_2449_0108"
                     /evalue="8.80E-14"
                     /label="ctg1_2449"
                     /locus_tag="ctg1_2449"
                     /protein_end="225"
                     /protein_start="159"
                     /score="51.4"
                     /tool="antismash"
                     /translation="AKSELITNVSHDLRTPLTSIVGYVNLIHHDNYRDEVELRHYIQVI
                     YDKVTRLNALMNDLFEYTRVQ"
     CDS             complement(20608..21303)
                     /gene_functions="resistance (resist) vanR (Score: 292;
                     E-value: 1.9e-89)"
                     /gene_functions="regulatory (smcogs) SMCOG1008:response
                     regulator (Score: 212.2; E-value: 1.2e-64)"
                     /gene_kind="regulatory"
                     /locus_tag="ctg1_2450"
                     /transl_table=11
                     /translation="MNKNILIIDDDKEIVELLAVYLRNEGYNIYKAYDGDEALQMISTY
                     EVDLMILDIMMPKRNGLEVCQEVRENNTVPILMLSAKAEDMDKILGLMTGADDYMIKPF
                     NPLELVARVKALLRRSSFQNASSPKNEDGMIRIRSAEIHKHNHTVKVNGEYIKLTSIEF
                     DILYLLASNTGRVFSSEEIFERVWNEDGYGSNKTVMVHISNLRDKLETGMNGEKFIHTV
                     WGVGYKIEK"
     PFAM_domain     complement(20617..20844)
                     /aSDomain="Trans_reg_C"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00486.30"
                     /description="Transcriptional regulatory protein, C
                     terminal"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_2450_0111"
                     /evalue="8.50E-25"
                     /label="ctg1_2450"
                     /locus_tag="ctg1_2450"
                     /protein_end="229"
                     /protein_start="153"
                     /score="86.7"
                     /tool="antismash"
                     /translation="EYIKLTSIEFDILYLLASNTGRVFSSEEIFERVWNEDGYGSNKTV
                     MVHISNLRDKLETGMNGEKFIHTVWGVGYKI"
     PFAM_domain     complement(20962..21291)
                     /aSDomain="Response_reg"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00072.26"
                     /description="Response regulator receiver domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_2450_0110"
                     /evalue="2.50E-29"
                     /label="ctg1_2450"
                     /locus_tag="ctg1_2450"
                     /protein_end="114"
                     /protein_start="4"
                     /score="101.8"
                     /tool="antismash"
                     /translation="ILIIDDDKEIVELLAVYLRNEGYNIYKAYDGDEALQMISTYEVDL
                     MILDIMMPKRNGLEVCQEVRENNTVPILMLSAKAEDMDKILGLMTGADDYMIKPFNPLE
                     LVARVK"
     CDS             21495..22103
                     /locus_tag="ctg1_2451"
                     /transl_table=11
                     /translation="MLYKDIYSFTPTGKIETDIKAFLLKYNKEVTYKHSIRVANESRKI
                     AVMYHVNEEKAAIAGYLHDISAIFPNEVRITVAEEFGIDLLEEERKFPMIIHQKLSRVL
                     AKEIFKVHDEETLNAICCHTTLRKHATKMDLVLFVADKIEWDQNGTPPYLVEVKKGLEK
                     SLEHAAFAYISYLWDRKDTLKVLHPWLEDAYWQLKEIVE"
     aSDomain        21579..22019
                     /aSDomain="TIGR00488"
                     /aSTool="tigrfam"
                     /description="TIGR00488: putative HD superfamily hydrolase"
                     /detection="hmmscan"
                     /domain_id="TIGRFam_ctg1_2451_0019"
                     /evalue="6.00E-22"
                     /identifier="TIGR00488"
                     /label="ctg1_2451"
                     /locus_tag="ctg1_2451"
                     /protein_end="175"
                     /protein_start="28"
                     /score="76.3"
                     /tool="antismash"
                     /translation="EVTYKHSIRVANESRKIAVMYHVNEEKAAIAGYLHDISAIFPNEV
                     RITVAEEFGIDLLEEERKFPMIIHQKLSRVLAKEIFKVHDEETLNAICCHTTLRKHATK
                     MDLVLFVADKIEWDQNGTPPYLVEVKKGLEKSLEHAAFAYISY"
     PFAM_domain     21585..21926
                     /aSDomain="HD"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF01966.24"
                     /description="HD domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_2451_0112"
                     /evalue="5.10E-12"
                     /label="ctg1_2451"
                     /locus_tag="ctg1_2451"
                     /protein_end="144"
                     /protein_start="30"
                     /score="46.2"
                     /tool="antismash"
                     /translation="TYKHSIRVANESRKIAVMYHVNEEKAAIAGYLHDISAIFPNEVRI
                     TVAEEFGIDLLEEERKFPMIIHQKLSRVLAKEIFKVHDEETLNAICCHTTLRKHATKMD
                     LVLFVADKIE"
     CDS             22372..22677
                     /locus_tag="ctg1_2452"
                     /transl_table=11
                     /translation="LYCTYQFSLKYFAGDIKYKRFIQAANHEDLPGLYPSLGRKKEISY
                     PDVFLINATKDIIMFMYDDRGSEVISKNKETIRNLYEKYKEWIPDYKRESIDKLFK"
     PFAM_domain     22546..22659
                     /aSDomain="DUF3885"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF13021.8"
                     /description="Domain of unknown function (DUF3885)"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_2452_0113"
                     /evalue="6.90E-19"
                     /label="ctg1_2452"
                     /locus_tag="ctg1_2452"
                     /protein_end="96"
                     /protein_start="58"
                     /score="67.8"
                     /tool="antismash"
                     /translation="MFMYDDRGSEVISKNKETIRNLYEKYKEWIPDYKRESI"
     CDS             22674..23411
                     /locus_tag="ctg1_2453"
                     /transl_table=11
                     /translation="MTVREVKFVMKRIAIVAAWEPELTYLHQSYPSERIEKRAAWEFHF
                     HTINDLEIISVITGVGKVSCASCAQLLISEFQPDELFMTGICGSLSTKVKNGHIVVALN
                     AIQHDVTAAGSGEDVFNLYNGRTAPIETTKSLVRRIKKIRSYDPIHFGTFLSGDQRIRS
                     SEMRYLLHTVYGALAVDQEVAAFAYVCQINKKPFLCLKAASDQANDKTKEEQKIFKMLA
                     CERACEHLIAFLRVYEINVVNHR"
     aSDomain        22707..23330
                     /aSDomain="TIGR01704"
                     /aSTool="tigrfam"
                     /description="MTA/SAH-Nsdase: MTA/SAH nucleosidase"
                     /detection="hmmscan"
                     /domain_id="TIGRFam_ctg1_2453_0020"
                     /evalue="2.10E-21"
                     /identifier="TIGR01704"
                     /label="ctg1_2453"
                     /locus_tag="ctg1_2453"
                     /protein_end="219"
                     /protein_start="11"
                     /score="74.5"
                     /tool="antismash"
                     /translation="RIAIVAAWEPELTYLHQSYPSERIEKRAAWEFHFHTINDLEIISV
                     ITGVGKVSCASCAQLLISEFQPDELFMTGICGSLSTKVKNGHIVVALNAIQHDVTAAGS
                     GEDVFNLYNGRTAPIETTKSLVRRIKKIRSYDPIHFGTFLSGDQRIRSSEMRYLLHTVY
                     GALAVDQEVAAFAYVCQINKKPFLCLKAASDQANDKTKEEQKIFK"
     PFAM_domain     22707..23375
                     /aSDomain="PNP_UDP_1"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF01048.22"
                     /description="Phosphorylase superfamily"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_2453_0114"
                     /evalue="8.60E-38"
                     /label="ctg1_2453"
                     /locus_tag="ctg1_2453"
                     /protein_end="234"
                     /protein_start="11"
                     /score="130.0"
                     /tool="antismash"
                     /translation="RIAIVAAWEPELTYLHQSYPSERIEKRAAWEFHFHTINDLEIISV
                     ITGVGKVSCASCAQLLISEFQPDELFMTGICGSLSTKVKNGHIVVALNAIQHDVTAAGS
                     GEDVFNLYNGRTAPIETTKSLVRRIKKIRSYDPIHFGTFLSGDQRIRSSEMRYLLHTVY
                     GALAVDQEVAAFAYVCQINKKPFLCLKAASDQANDKTKEEQKIFKMLACERACEHLIAF
                     L"
     CDS             23428..24063
                     /locus_tag="ctg1_2454"
                     /transl_table=11
                     /translation="LESTNKIAILGANGKAGKILVNEALEKGYQVKILTRNSTNTEKIN
                     KNIETIIGDARNFSTIQDLLQGCSAVINAVGQPKNESYIFSTVTKHILEAMKESKIKRY
                     ILISGGSLNVTGDQKGIINKIGATLFKLFLPKMMQDKYKELQIIQNSEVDWTIVRLPFV
                     IEGNGIGSIKESLVDMPGIKIQNGDIAPFVIKQINSDRYVGKCPFISN"
     PFAM_domain     23458..24024
                     /aSDomain="NAD_binding_10"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF13460.8"
                     /description="NAD(P)H-binding"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_2454_0115"
                     /evalue="3.00E-32"
                     /label="ctg1_2454"
                     /locus_tag="ctg1_2454"
                     /protein_end="199"
                     /protein_start="10"
                     /score="112.1"
                     /tool="antismash"
                     /translation="GANGKAGKILVNEALEKGYQVKILTRNSTNTEKINKNIETIIGDA
                     RNFSTIQDLLQGCSAVINAVGQPKNESYIFSTVTKHILEAMKESKIKRYILISGGSLNV
                     TGDQKGIINKIGATLFKLFLPKMMQDKYKELQIIQNSEVDWTIVRLPFVIEGNGIGSIK
                     ESLVDMPGIKIQNGDIAPFVIKQINS"
     CDS             24157..25005
                     /locus_tag="ctg1_2455"
                     /transl_table=11
                     /translation="MIQYKRCSEINIDLVYEAFRDGFSDYIIKMEVSKGDFIKRFFGLE
                     GNSLEHSFLALDGDKPVGVILGGIKDYENIKTMRCGTLAVHPNYRGVGVSQKLFELHKE
                     EALQNECKQLFLEVIVGNDRAIRFYNKLGYEKVYDLSYYNLKDMTKIIHRECKGIEVKQ
                     LEFAAFKVEIQKWLHFHINWQNDMDYIEKTNHTFYGAYVDNDLKGSICINEQGKISFIF
                     IDKEYRNRGIGSKLLQVARDELNLESLLISFPNNSLLEGFVKKTGFEKNSLAQYEMYVL
                     L"
     PFAM_domain     24295..24558
                     /aSDomain="Acetyltransf_1"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00583.27"
                     /description="Acetyltransferase (GNAT) family"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_2455_0116"
                     /evalue="1.60E-14"
                     /label="ctg1_2455"
                     /locus_tag="ctg1_2455"
                     /protein_end="134"
                     /protein_start="46"
                     /score="54.2"
                     /tool="antismash"
                     /translation="NSLEHSFLALDGDKPVGVILGGIKDYENIKTMRCGTLAVHPNYRG
                     VGVSQKLFELHKEEALQNECKQLFLEVIVGNDRAIRFYNKLGY"
     PFAM_domain     24670..24984
                     /aSDomain="Acetyltransf_10"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF13673.9"
                     /description="Acetyltransferase (GNAT) domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_2455_0117"
                     /evalue="2.80E-12"
                     /label="ctg1_2455"
                     /locus_tag="ctg1_2455"
                     /protein_end="276"
                     /protein_start="171"
                     /score="46.8"
                     /tool="antismash"
                     /translation="EIQKWLHFHINWQNDMDYIEKTNHTFYGAYVDNDLKGSICINEQG
                     KISFIFIDKEYRNRGIGSKLLQVARDELNLESLLISFPNNSLLEGFVKKTGFEKNSLAQ
                     Y"
ORIGIN
        1 ttgaagatac gcaaacactg aaaagagaaa cagtaccgta tagtatgatt catgttgttc
       61 cacctatggg gccacctaat tttcttaaag agagcgaaat aagtgatcat cagggttgga
      121 tagatataag cccttatact ttgcaacatg taaagtataa gaatattttc ggacttggag
      181 attgtaccaa tttacccacc tctaaaactg gagcggcaat tcgaaaacaa ataccgatct
      241 taaaacaaaa tattatggac gtactaaacg gaagagattt gcaggctaaa tatgatgggt
      301 atacatcttg tccgattatt acaggatata aaagtcttat acttgctgaa ttcaactacg
      361 aacatgagcc tcaagaaacg tttccgttca atcaagcgaa agaacggtat agtatgtttt
      421 tacttaaaag atatatgttg ccctatatgt attggaactt tatgttgaaa ggaatcctat
      481 aagggaagag agaaagcggt tataaaaatt gaaaagcatt ttgaattaac tatttggagg
      541 gaatagctat gcttttaaaa tatttttatg atgaaaaatt agcacatgct tcttatttag
      601 ttggttgtca gaaggaaggc gtagcaattg tgattgatcc aggtcgctat atagaacaat
      661 atatagactt tgctaagaaa gaggggatgg aagtaattgc tgcggctgaa actcacattc
      721 atgcagattt tctttctggg tctagagaac tttccactct ttatcatacc aatttatatg
      781 tatctgatga aggtgattgt gattggaaat atcaatatct taacgaaggt cgatataatt
      841 tggttagaga ggggacagag tttaaagtag gtcatataaa atttaatgta attcacacac
      901 cagggcatac acctgaaagc atttcttttt tagtaactga tacaagtcaa aataactata
      961 cgaatgataa gccaatagga atattcacag gtgattttat atttgtcgga gatataggaa
     1021 gacccgattt attagaaact gctgtaggta tgaaagatac cgcaaaaata ggagcaaaac
     1081 aattatttga ttcgatacaa aaaataaaaa cactccctga ttatttgcaa atatggccat
     1141 cacatggtgc aggaagcgca tgtggaaaag cattaggagc aattccaact tctaccttag
     1201 gttatgaaaa gatgttcaat tgggcatttc agtgtaatga agaaagtgat tttatatcga
     1261 ctttattggc ggggcagcca gagcctccaa ggtatttttc tttaatgaag aatttaaata
     1321 agtatggtcc gcccattcgt aagaaaagag agatttttgc tattaaaaca gtagaggaac
     1381 ttcaagaagt tatgaggagc gttcagcaaa tagttgatat aagggatgga gagagttttg
     1441 cttctggtca catcgagaaa tcaattaaca taccgtgtaa caattccttc acaacctggt
     1501 gtggatggtt actagattat aaaacagaaa ctttaatcat tctagatgag gaaaaggtta
     1561 gagtggagga ggttattaga gactttgaat ctattggtct agataatatt attgcctttg
     1621 cacccttaca agtaatacaa agactcgata gatttgaaag ttacaaagaa aaaacatcga
     1681 ttgaattata tccgcatata aaggatggta gggttaaggt aattgatgta cgtagtaaaa
     1741 aagagtggga cgaaggacat cttcatgatg caatacatat ccctttggga aatctattga
     1801 agcagctaga ttgtatacca aaggattgcc caatcgtttt acaatgtcga accggattac
     1861 gttccgctat agcagctagt attttacaga gagctggtat aaaggaagta gttaatctaa
     1921 agggaggatt tcttgcatgg aataaagaag agcttcctta tacaacttgt aatctcaatg
     1981 tggagggaaa taatttttat taatttatcc gataaggaaa attacggatt acataggagt
     2041 atatctataa ataggagaaa tagataattt attctataga tctaaattta ttcagtatta
     2101 tgctgatgag caaatggata tagttttatc aggccacgct cagggtggac aatttaagtt
     2161 actatttatc agcaaattag tggctctaaa tcaaggtgtt ttacctacat attcagccgg
     2221 tttatatgaa aaacaaaata cgtctatggt agtaagtaga ggattaggta atagtaacat
     2281 tccgcaaaga atttttaata ggccagaact tgtagtcgta cagttaaatt gaactgtacg
     2341 acttttctat acagaaaaaa taggacatat gcattttata caagttaaca ttacaatttt
     2401 gttaaaaatt ttctacgtta cataaagtaa caaaatttga cctgaagagt ttgttatagt
     2461 gtaaataatc aaaaaattaa aaattagtcg agtgaaaagt gtgataagta attcatataa
     2521 aaaacttaaa ggggtgtaca catgcataaa gaatatgaaa ttgaagaata cacggcgatt
     2581 gaggaacaaa tccattatta ttgtaaatgt ttattagtaa ctcatcctga tcaaattata
     2641 aagtatttag aaaaaagatt agaaaaatat gcagaaacat tacaatatgc acatttatat
     2701 cccgacacag ttatattacc gttacagcaa ttagttatcg aatattcttt agatgttgct
     2761 agaattagga agtatatgaa tttaaaaacg taaagtaaaa tatataattt aaatgaaaca
     2821 gagtcgactt taggaaatga aattctaatg tcgactctgt ttcattgttt aatattgttg
     2881 acggaaaatc atactaatca atgaagtttg acatataatt acgcaagagt aaaaaataag
     2941 tgagtactca ctcattttta ttggaaaagg aggatgaaac gtgcaacaac cttaaattat
     3001 tttacggact gtatcaaaaa gttttggaaa aaaagaagtg ttacacaatc tttcattgca
     3061 agttgaaaaa gcagagatat ttggtttagt tgggccttca ggttctggga aaacgactct
     3121 tattaaattg attgcaggta ttaacgaagc aacggaaggt gaagtgcttg tttacaacac
     3181 gaacatgcct aatttaaatg aaatgaaaag aattggttat atggctcaag ctgatgcatt
     3241 atacgaagaa ctatcagcat atgaaaatgc agattttatg gcaacgatgt acggattaaa
     3301 gggaaagcat aaaaaagaaa gaattgaaaa ggtttttgat cttgttcaat tatcacaaca
     3361 tatgaaaaag caagtgcagc atttttcagg cgggatgaag aagcgtttat cattagcaat
     3421 agcactcctt catgaaccag aaatattaat tttagatgag ccaacagtgg ggatagatcc
     3481 gcttcttaga aaaacgattt gggaaaaatt ttatgatttg aaaaagaaag gcactaccat
     3541 tattgtaaca acacacatta tggacgaagc tgaattttgt gaacgcctag ggttaattag
     3601 agaaggaaag ctagttgcga ctggtacaac tgaagaattg aaaaagcggg tatcatcagg
     3661 aaggattgaa gatgtctttt tgttggaaga ggtggctgaa ttatgagagt aaccggtgta
     3721 atcattcgta ttattcgcca attttttcga gataaacgtt cgttagcgat gatgtttggg
     3781 gcacctatgt tattactttg gttattgtca ctagtgttta cacaaaagga ctatgtaccg
     3841 catattgctg ttgttgatat gcccgctcag ttagtaaaag tgatgaaaaa tcaggaagcg
     3901 tcaatttatg aatataatac agaaaaggca atgtctgagc tagaaaatca aaaggtagat
     3961 gcagtcattc gtttagaaaa tggaaaaatg aatattgtat tagaaggtag tgattcgtca
     4021 aaaaatcgtg ctgtacttca aatattacaa aaaagtacag agaagaacga tatatcgata
     4081 atgaaacctg aagtgaatta tttacatggc tctaaagact ttacaatgtt tgatgggctt
     4141 ggccctgtat tgattggttt ctttacattt ttctttgtat ttattttatc aggggtgtct
     4201 ttcgtaagag aacgtttaag cggtgcgtta gaaaggttat tatcaactcc aattaaaaga
     4261 tgggaaatag ttgtaggata tattattggt tttgggatct ttgcatttat acaatccatt
     4321 ataattgtaa gtttttcagt ttatatttta gacttgtatg tagctggctc tatatggcta
     4381 acgctactta ttacatgtat gctttcttta acggcattaa ctttagggac atttttatca
     4441 gcatacgcaa ataatgaatt tcaaatgatt cagtttatac cgcttgtcat tgtgccacaa
     4501 atattctttt ctggtttgtt tccaattgaa tcgatgaata agtggctcca aatgttaggg
     4561 aaattatttc cgctcacata cggcgctgac gcaatgagac aggtgatgat tcgaaatcaa
     4621 ggatttacag agattgcatt agatttaact gttttactat ttttctcagt attatttgca
     4681 gtagggaatg tatttgcatt aaagaaacat cgaaaaatat aatgatgata caaaggggta
     4741 ttatagatga agaaggattg gttggaagaa ttaattgccg caacaaatac agacaaacga
     4801 aatgaacgtc aaatgcgtat attagaggcg gctgttgata tgtttggaga aaaaggttat
     4861 gcttcaactt caacaagtga aattgcaaaa cgggctggtg tagcggaagg aacaatcttc
     4921 cgctactata aaacgaaaaa agatttatta ttagcagttg tcatgccgac attaatgaag
     4981 tttgctgcac catttttcgt acaagcattc gcaaaggaaa tatttaaatc ggagtatgaa
     5041 tcatatgaag ggcttctaag agttgttatt cataatagat ttgactttgc aaaaaagcat
     5101 tttccaatga taaaaatatt aattcaagaa gtgccatttc acccggaact gaaaaatgaa
     5161 atacaacagt tagttgaaac agaattactt ttacatttta aaaagttgat tgaaaagttt
     5221 caagaaaaag ggaaaattat tgaaatgccc ccagctactg ttttacgact tactttatca
     5281 gctgtatttg gtttattatt aacacggttt ttattattgc ctgaagaaaa atgggatgat
     5341 gaaactgaaa ttgaaaatac gattcagttt atattgtacg gattaacgcc acgaaattaa
     5401 tcgtcgaagt atgaattaca tatgttacat ttaagtaaaa taataaatcg cctttaaaaa
     5461 ggcgatttat atttgttata tttttgataa ataagtactt gtttactaaa aacattctaa
     5521 attaacgtac ttctttgtct cttcttctaa gacctaataa tcctgctagt cctaataaac
     5581 cgagccaagc ccaattatta tttctatcac gattatcatt taaatcattt gttgtattta
     5641 catttcgagt tcttacatca ttattaactc tgtctaagtt attgtcattc actcgagttg
     5701 aaatgtcagt gttattaact ctattcatat tagttccatc gtattcagca tgggcagatg
     5761 tacctaaaaa cataatagaa agtgctaaaa cacttacaat agatgataat tttttcttca
     5821 taacgctccc tcctttctta catattaatt tctccagagc atgtgtgtat tattcgtttc
     5881 acagtttcta aaccgtcatt ataaaggaca catttataga aaatagagtt gaatgattgc
     5941 taatatatta ttggctatat atttatcata aaattaaatg catcaaactt tgcttaaaat
     6001 gttaatatta gtacaattta tattatacgg actagcatta aggaggtaat gaaatgcgac
     6061 aatttgcaaa acctacaatc gttgtaagta aatgtttaga gtttgatgct tgtcgttata
     6121 atggagagat gattccggat gtaactatac gaaatttgca gccatttgtt acatttatac
     6181 ctgtttgtcc agaagtcgag attggattgg ggactcctcg tgaaacgata cgcattgtag
     6241 aagaaaaagg ggtgaataaa cttgtgcaac cgtctacaag agaagacctc actgaaaaaa
     6301 tggagcaatt ttcaaatgaa tttttacaaa cgttatcaga tgtggatggt tttattttaa
     6361 aaaatcgttc gccaagttgt ggtacgcgtg atgtgaaaat ttattctggt tttgaaaaag
     6421 caccagcaaa agggaaagga ccaggcttat ttggtggtgc agtagtaaaa aaattttcgc
     6481 atcttccaat tgaagaggaa ggcagattgt cgaattttat tattagagag catttcttta
     6541 caaggttatt tacaatcgca tattacaaga tgattaaacg taataaaaat atgaaagacc
     6601 tcgtatcgtt tcagtcggat aataaatatt tatttatggc atataatcag gtgaaacaaa
     6661 aggaattagg gcgtattatt gcaaatcaaa aaaatgaaac gatcgaagtt gtatttgaaa
     6721 actatgagaa gactttatat gaattattta tgcgcacacc ccgctataca tcaaatgtaa
     6781 atgtatgtga gcatattttt ggatacttta aaacaaagct gaaaaaacaa gaaaaagatc
     6841 attttttaaa tttaatacaa aagtatatag aaaagaaaat tccgcttagt agcttacttg
     6901 caattttaaa atcatgggct cttcgatttg atgaaaagta tttattaaga caaacatatt
     6961 tcgaaccata tcctgaagct ttagtagaga tttcagattc aggtaaaggt agagattatt
     7021 aaacataaaa ttacataatt cgacaagaaa actcctatgt tgttgtagaa caatgtagga
     7081 atttttttgt gcattagtac agaatctgtt ttaaaattaa attatgacag aattataaca
     7141 attatctaac taatgttctt gtcttttcat tcgtaatgtt tgtagtagaa actcgcacgc
     7201 tgtcgaaact caatattcga taaggggtgt gtagcggaat ggaatttact ctaactcgcg
     7261 aaaaacaaat gattaaagaa atggtacgtg actttgctga aaaggaaatc gcaccgaaag
     7321 ctgtgtatta tgacaaaact gcagagtttc catatgaaac atttcaaaaa atgggcgaac
     7381 taggattatt aggcatccca ttcccagaag agtatggagg ttcaggtggc gatacagtat
     7441 cgtacgcgtt agcagttgaa gaaattggtc gtgcttgtgg tggaacagga ttaagttacg
     7501 ctgcaacaat ttcattaggt gcttctccaa tttattattt cggtacagaa gaacaaaaac
     7561 agaaatattt agttccaatg gcatcaggca aaactttagg tgctttcgga ttaactgagc
     7621 cgaatgctgg atctgatgca ggtggtacac aaacaaaagc tatattagat ggagacgagt
     7681 atgttattag tggtgagaag tgttggatta caaatgctga gtatgcaaat acaattattg
     7741 taaccgctgt caacggtatt gaagagaatg gtagaaaacg tatttctgca tttatcgtac
     7801 cgactactag tgaagggtta acgatttcaa gcccttacga taagatgggc gtacgtgctt
     7861 ctaatacttg tgaaatcgta cttgatggtg tacgtgtacc aaaagaaaat attcttggtg
     7921 atgtaaataa aggatttaaa caattcttat atacacttga tggaggacgt atttcaatcg
     7981 cagtattagc tgttggtatt gcacaatctg catttgaacg tgcattgcaa tatgcgaaag
     8041 aacgtcaaca atttggaaag gcaatttcta atttccaagc gattcaattt aaattagctg
     8101 atatggcgac tgaagtagag ctagcacgta atttagtaca taaagcagct tggttaaaag
     8161 ataacgataa acctttcggt aaagaagcgg ctatggcaaa acttttcgca tctgaggctg
     8221 ctagtcgtat tgcaaatcaa gcagtacaaa ttcacggtgg atacggctat atgcgtgaat
     8281 atgaagtaga acgacatatt cgtgatgcaa aactattaga aattggtgaa ggaacttctg
     8341 aaattcaacg tctcgtaatt gctagacatt taggatgtag ataaaaagga ggaatcacta
     8401 tgtttcaaaa aatattaatt gctaatcgcg gggaaatcgc agttcgtatt atgaaaactt
     8461 gtcaaaaact tggcattcgt actgttgcta tttattctga ggcagatgaa aatgccttac
     8521 atgtaaaaat ggcaaatgaa gcttacttag tgggtgggcc gcgtgtccaa gaaagctatt
     8581 taaaccttga aaaaataatt gaaatagcga agaagacaaa tgccgaagca atccatccgg
     8641 gatatggatt attatctgag aatccatctt tcccagtacg ttgtaaagaa gaaggaatcg
     8701 tatttatcgg tccatcagaa gaaatcatta cgaagatggg aagtaaaatt gaatcacgta
     8761 ttgcaatgca agctgcagat gtcccagtag ttccaggtat tactacaaat attgaaactg
     8821 ctgaagaagc aattgaaatt gcgaaacaaa ttggttatcc attaatgttg aaggcatccg
     8881 caggaggcgg aggcattgga atgcagttga tggaaactga gcaaacgctc accaaagcat
     8941 ttgaaagcaa caaaacaaga gcacaaaact tcttcggtaa tggagaaatg tatttagagc
     9001 gctatatagc agacgcgcat catattgaaa ttcagctttt agcagataca catggtaaca
     9061 cggtgtattt atgggagcgt gaatgttcag tgcagcgccg aaatcaaaaa gtgattgaag
     9121 aagccccttc accattttta gatgaaggta cacgaaaagc gatgggtgaa attgctgtac
     9181 aagctgctaa agccctaggt tatacaaatg ctggtacagt tgagtttctt gtagatgagc
     9241 agaagaactt ctatttctta gagatgaata cgagattaca agtagagcat ccagtgacag
     9301 aagaaattac gggtttagat cttgtagaac aacaactttt aattgcatat ggtgagaaat
     9361 tatcgtttac acaagatgat ataaaacgta gtggtcatgc cattgaggca cgtatttatg
     9421 cggaagatcc gaaaactttc ttcccatcac ctgggaaaat tacagattta acgcttccaa
     9481 caaacgtacg tattgatcac tttttggaga atcaagtaac gattacacct ttctatgatc
     9541 caatgattgc gaaagtcatt gctcatggtg agactcgtga agaagcaatt tcaaaattac
     9601 atgatgcttt agaagaatta aaagtagaag gtattaaaac aaacacgcca atgctactgc
     9661 aagtattgga agatgatgtg ttcaaaagtg gtatttatac aacgggtttt gtaacgaaac
     9721 aacttgttaa aaaataagat ttaaaaatac taagggggaa aaaatgatga cgaaagtata
     9781 tgcatcgatg gcaggaaatg tatggaagat tgttgtagga gtaggagata cagtagagga
     9841 agagcaggat gtcgtcattt tggaatctat gaaaatggaa attccaatcg tttcagaaga
     9901 agctggcaca gttatgaaaa ttaatgtgca agaaggcgat tttgtaaatg aaggagatgt
     9961 attactagaa attgaatagg gagatatagg gggaagcgaa ttgaaactac ctaattttgc
    10021 tgtcattaaa gaagtcgggc cacgtgatgg cttacagaat gaaaaaaaga ttgttggcac
    10081 aaaagataaa gtaaaatgga ttcaactact tacagaggcg ggattatcgt acgttgaagt
    10141 ttcctcattc gttcacccta aatgggtccc tgcattggca gatgcaaatg atgtgttttc
    10201 agagctgaaa agggacccaa atgttacata tgcagcgctt gttccaaatc aaaatggttt
    10261 ggaacgagct tttttgcaaa atgtagatga ggtgaatgtt tttttatcag caagtgaatc
    10321 tcataataaa agtaatatta ataaatccat taaagaagca ttagttgtaa ttgaagatat
    10381 aacaaaacag gcattattcg agggcaaaaa agtaagaggc tatgtgtcta ctgtatttgg
    10441 atgtccttat gaaggggata taagtgccat agcagttgac gaattatgtg atcaactatt
    10501 ttcatatggc atttatgaag tgtctcttgg cgacacaatc ggagtagcga atccgttaca
    10561 agtagagcga gtattagagc atttattaaa gaaatatgat gcttcgcagt ttgcaatgca
    10621 cttccataat acgtacggaa tggctcttgc aaatgtagta aagtctttag aatatggcat
    10681 tacaacattt gatagttctt gtggtggtct tggcggctgt ccatatgcac caggagcatc
    10741 aggaaatgtt gcaactgatg acttagttca tatgctccat aagttagggg tccaaacgaa
    10801 tattgatgaa gagaagttat taagagcgag tcaatttatt caaagtaaat taaatatcca
    10861 attaccgagt catgtgtata gagcgcttca acataaaacg ataagtaggt gagaagatgc
    10921 tacaattaca aaatatttca gttgattatg caacaccgca cgttgtaaag atttcattaa
    10981 atcgtgaaag acaagcaaac tcattatctt tagcgttatt agaagagtta caaaacatat
    11041 taactcaaat aaatgaagag gcaaatactc gtgtagttat tttaacaggt gctggtgaaa
    11101 aagcgttttg tgctggtgct gatttaaaag aacgtgctgg catgaatgaa gaacaagttc
    11161 gccatgctgt tagtatgatt cgcactacta tggaaatggt tgaacaatta ccacagccag
    11221 ttattgctgc tataaatggc atcgcacttg gtggtggtac ggaattaagt ttagcttgtg
    11281 attttagaat tgcggctgaa tctgcgagtc ttggtcttac tgaaactaca cttgcaatta
    11341 taccaggagc aggtggtacg cagcgtttgc caagattaat tggtgttggt agagcgaaag
    11401 aattaattta tacaggaaga cgtatttcgg cacaagaagc gaaagaatat ggtctagtag
    11461 aatttgttgt accagttcat ttacttgaag aaaaagcgat tgaaatagca gagaaaattg
    11521 ctagtaatgg tcccattgct gttcgattag cgaaagaagc aatttcaaac ggtattcaag
    11581 ttgatttaca taccggatta caaatggaaa aacaagcgta tgaaggtgta atccatacga
    11641 aagacagatt agaaggatta caggcattca aggaaaaacg cacaccaatg tataaggggg
    11701 agtaaatatg atagaccaaa aacaacaatc gaatacattt gaagaacgag ttgaaacgat
    11761 taaacgaggc ggcgcaccaa aatatcatga acaaaataaa gcgaaaggta aactattcgt
    11821 tcgagatcgc ttagctcttt tatttgataa tggtgaatat gtagaagatg cattatttgc
    11881 aaattgtgaa gaaacgggat tacctgctga tggtgttata acggcaacgg gaaaaataca
    11941 tggtcgtact gcatgcgtaa tggcaaatga ttctacggta aaggctggat catggggcgc
    12001 acgtacagtt gaaaagattt tacgtattca agaaacggca gaaaaattac gtgttccgtt
    12061 attttattta gttgactctg ctggggcgcg tattacggat caagttgaaa tgttcccagg
    12121 gcgccgcggt gcaggaagaa tcttctataa tcaagtgaaa ttatcaggta aagttccgca
    12181 agtatgttta ttatttggac cttctgcagc tggtggcgca tatattccag ccttttgtga
    12241 cgttgttatg atggtagaag ggaatgcttc tatgtattta ggatctcctc gtatggctga
    12301 gatggttatc ggtgaaaagg taactttaga agagatgggc ggagctcgta tgcattgctc
    12361 tatatcagga tgtggagatg ttttatgtaa aacagaagaa gatgcgatta cacaagcaag
    12421 acaatacatt tcatattttc caaacaacta cttagaaaag actccattgg ttacacctca
    12481 agaaccgaaa caattcgata aaacgttaga acaaatcatt ccagaaaatc aaaatgctcc
    12541 tttcaatatg aaagatctta ttaatagagt tattgatgaa ggttctttct acgaagtgaa
    12601 aaaattattt gctcaagaac tcattacagg tttagcacgt attgatggta agccagtagg
    12661 tattattgca aatcaaccgc gaatgaaagg cggcgtatta ttccacgatt cagctgataa
    12721 agcagcgaag tttataaatt tatgcgatgc atatcatatt ccgttattat tccttgcaga
    12781 tgtacctgga tttatgattg gtacaaaagt agaacgtgct ggtattattc gtcacggtgc
    12841 aaaaatgatt tctgcaatga gtgaagcaac tgtaccgaaa atttctatcg ttgttcgtaa
    12901 agcatatggt gctggtttat atgcgatggc aggtccagcc tttgaaccag attgctgcct
    12961 agcattaccg acagcctcta ttgcggtaat gggtccagaa gccgcggtca atgctgtata
    13021 tgcaaataag attgcagctt tacctgaaga agagcgtgat agcttcattg ctgaaaaacg
    13081 agaagagtat aagaaagata ttgatattta ccatttagca tcagagatgg tcattgatgg
    13141 tattgttcat ccaaacaatt taagagaaga gttaaaagga cgattcgaaa tgtatatgag
    13201 taaatatcaa gtatttacgg atcgtaaaca tcctgtttat ccagtttaaa agccctattt
    13261 agggctttct tgctcaaaaa gttaaggagg ggaaaacatt gaaacaagca gtttggtttc
    13321 caacagaaga gtataaagaa aaaacacgct tatatggttg gatgaaatca ttggggtatg
    13381 aagattatga aacgttttat aataaatcta ttgaagaaac agcttggttt tggggagaag
    13441 ctgagaaagt ggttggctat caatggatga aaccttatac agaagtgtta gacctgcaaa
    13501 atggtacacc gtttgcacag tggtataatg gcggaacatg taacgttgta gaatcagttt
    13561 tatcacgctg gcttgcagat gatgaaacaa gaacgcaacc agcacttcag tatgaaggag
    13621 aaaatggaac ttcaaaatca tttacatatg aagaacttga tagctgggta agtcgcgctg
    13681 caaatggttt gaaacatgcg ggtattgaaa aaggcgaccg agtaacaatt tatatgccaa
    13741 tgattccaga aacagttgtt gcgatgctag ctgtaatgaa aatcggagca attatttcac
    13801 caatattctc aggatttgcg tctgatgcag tcatgacacg cgtgcaagca gcaggatcaa
    13861 agatgatcat tactgcagat ggtttttcac gccgaggtaa gattgtttca ttaaaagatg
    13921 aagtagataa agcttgtgag cattgtccaa ctgttgaaaa agtcgttatc gtgcgccacg
    13981 caggaaatga ttttacaccg cataattatg atttctcatg gagtacgtta gaaaaagaaa
    14041 agccatttgt acatgctgaa gaaatgcata gtgacgatcc gttaatgctc atttatacat
    14101 caggtacaac aggaaaaccg aaagggaccg tgcacactca tgctggtttc cctttgaaag
    14161 cagcatttga tgcagggttt gggatgaata taaaacaagg cgaccgcgta ttatgggtaa
    14221 ctgatatggg ctggatgatg ggaccatttt tactatttgg ctctctcatt aatggagcaa
    14281 cgatggttat gtacgaaggt gttccggatt tcccaaaagc agatcgttta tgggagacag
    14341 ttgataaata tgaaattaca catcttggta tatcaccaac attaattcgt gcgttaatgg
    14401 caaaaggtga tgagtatgta aataaacatt cgcttaagag tttagaagta tttgcctcaa
    14461 caggcgagcc ttggaatcca gatccttgga tgtggctatt tgaaacagtt ggaaaaagta
    14521 atgtgccaat ttgtaactat tcgggcggaa ctgaaatttc tggtgggatt ttcggaaatg
    14581 tccttattaa accaattgca ccgataagct ttaacgcttc tttaccagga atggcagcgg
    14641 ttgtgctcga tgatcaaggt aatccaattc gtgatgaagt tggagaatta tgtttagaga
    14701 aaccttgggt tggtatgacg aaaagtttct gggaagacga tgagcgttat gtgaacacat
    14761 attggtcacg ttttgaaaat aaatgggttc acggtgactg ggtggtttat gatggtgagc
    14821 aatatattat tacagggcgc tcagatgata cgctaaacat tgctggaaaa cgcattggac
    14881 ctgctgaata tgaatctatt cttgtgaagc ataatgatgt catagaagct gccgcgattg
    14941 gtgtaccaga tgatgtaaaa ggtgaagttt gtcattgttt tgtagtatta agagataatg
    15001 taacatttac aggagaatta aagaaagaat taatgagttt agtaaactct catattggaa
    15061 aagcattatg tccaaaagat attcacgttg tagaagattt accgaaaaca cgtaattcta
    15121 aagtaatgcg acgcgtcatt aaagctgctt atttagggaa agaactaggt gatttatcat
    15181 cacttgtaaa ccctgaagta gtgccattta ttcagggatt gcagtctagt aaattataaa
    15241 attaaagcat gtataatgtg aactgacctc taacaattag aggtcagttt ttatgtatac
    15301 agaatagttt agtacatgtg tttgtttttt cttttctatg tttttgcctc gtacactttg
    15361 aagctagtgg acatactata ttaatagaaa tgactagggg gtgagatttt gggatctcgt
    15421 tatagtaatt ctagaaaaaa gtgttcatgt aaacagtgtt catgtaaaca ggatgattgt
    15481 tgggatgttt ttgaagagtg taaaaaagaa catgaagagc aaaataaggc atgtgactgt
    15541 tgctgtgtac aaggaattag agatgagctg agaaagttag taaacagatc agtgcgtatt
    15601 acaacaggaa gtaataatta tgcaggaact gtttcttcag tcacttgtga tgttgtaaag
    15661 cttgctaata gtgctggggt agttacagta attatttcag tttgtaaaat tgaagcgatt
    15721 gaagcattgt taacataaga aacatggcat aatggggcta tgttttttgt aaagccattc
    15781 ttatgaatgg ctttactttc atttcgtata aaaggagaat atattctata tatagaaata
    15841 agtttgagga tatatagaat ggtgtatgaa aggagaatga agttgattaa attagaaccc
    15901 tttaaacgat ccgatttcaa acgattaata aactggattg attccgaaga atttttaata
    15961 cagtggtctg gaaatgcatt tacatatccc ctacatgaac aacaattaga aaaatatata
    16021 gaaagtgaaa atacacttgc attcaaagta atagatgaag agactaaaga agtaattggt
    16081 catatttcac ttgggcaaat agaccatata aataaatctg caaggattgg taaagtacta
    16141 gttggtgata cgagaatgag aggacgttcc atagggaagc atatgatgaa agcagtactt
    16201 catattgcat ttgatgaatt aaaactacat agagtaacgc ttggtgttta tgattttaat
    16261 acatcggcta tttcatgtta cgaaaaaata ggatttgtaa aagaaggctt attaagagag
    16321 tcgaaaaaag taggggagac atattggaat ttatgggaaa tgagtatgtt agaatatgaa
    16381 tggggcgata aaaaacaata gttgtttata attatgttat gtcgattaaa aggggtatgg
    16441 tgggaattta tgaataaaaa aacgaaaatt attacaattg cagctgtttc aggaggaggt
    16501 aaaactactg ttacagaaag attaactcat aaattaatga attcaaaagc actatatttt
    16561 gatagatata actttgataa ctgtcctact gatatttgta aatggattga tgatggagcc
    16621 aattatgatg aatgggtact cacaccatta attaaggata ttcagcatct tatacgagat
    16681 agtaatgtag attatattat tgtagattat ccttttgcat acttaaatag tgaaatgcga
    16741 caattcattg atgtaactat atttatcgat acgcctttag atattgcaat ggctagaaga
    16801 attttgcgag attttaaaga agatacaata agtgaaatac ataatgattt agagcattat
    16861 ataaactatg ctagaaaagc ctatttggag gcacttcata ctgtaaagcc aaattcagat
    16921 attgtgttgg atggagcatt atctgtagat caaataatta atcaaattga agaagaactt
    16981 tatcggagag aagtgatcgc caatggttaa aagtatagaa aaatatgtac aagttgatga
    17041 ttttaaaata tattcaaaag tatttcaagg aaagaagttg cagcctgtta ttataatgga
    17101 agcaggttat ggtgattatt caaaggcatg ggaccttatt gctgaagaat tgacggaata
    17161 tgggacagta ctcacatatg atcgagcggg agtagggaaa agtggcaaga gttccaagcg
    17221 acgtattagt tctgaaatga taaaagattt gagaagttgt ttagagcaat tacaattgaa
    17281 accaccttat atttttgtag gacattcttt tggtggtata aatgcacgtt tatttgcgaa
    17341 tttttatccc gaagatatgt cgggaatcgt tttggttgat tcgacaccgg aaaattataa
    17401 agaagatttt ttgccaatca tgtcactgga atttcaggaa gcttactata aacagtttgt
    17461 atatgaaagt tcttatgaag agtttatgtt tagtctaagt gaagcaaata aacattgtca
    17521 gtcaatgaga aatattccac ttgccgtatt agttactggt aaaaaagcct attattcgca
    17581 agaagcacaa atgaagtggt tacaattgca agaagaatta ttacgcttat caaacaatca
    17641 tacatttgta attgcagaac aaagtggtca ctatattcaa aaagatgagc ctcattatat
    17701 tatagatgct gttaaatgga taattgaggt agaggagaga taaatgtgta tactttattt
    17761 caatacaatt ggcaagtgag agatgattgg tttaagtggt gtgagcaact ttcaaaggaa
    17821 gaattactcc gtaagcgtat tggtggtgtt ggaagtattt tagaaacatt atttcatatt
    17881 gtagatgttg agtatagctg gattaatgcc cttcaagaaa aagaagattg tgtaccgcaa
    17941 tttaaagagt atcaatctat ccaaaaagtg aaagcgttat ctaatttata taaaagagaa
    18001 ttagaagatt ttttacaagt atggtcagct aacttagaat gtaaaatatt aaaagcttcg
    18061 tggacagata aaacatatac atatggtgag gtcttaaggc acgtaattgt acatgaaatt
    18121 caccatatcg gtcagctatc tatatgggca agggagttaa atcttcggcc tgtttcagcg
    18181 aatttaattg ggagaggact ataaatttag aaaacggctt gcactgtaaa tgcaagctgt
    18241 tctttatata taagaagatt tcctagttga aatcctcgga ttttttttga cgtatatgta
    18301 aaagcattaa aattgtaata ataaagaaaa tcaacaatgt ttgtatgatc aaatttttaa
    18361 actgaagcaa aactgcccaa gatgtaacag catctttaaa tgcttggagt gcagagtatg
    18421 aggagggatc aaagccgtac tgtagtaatt tttttgtttc aataaaagta ctgttttcat
    18481 tatcggcgtc taatattact gaaataagtc tagtatctcc tcgttttgct gtactgacaa
    18541 aactataatt actattagtt gaaaaactag tttgtaagcc atcaacacct tggagtttaa
    18601 tgtttttatt tagggaataa atcattttat tggtattgaa aactttggta tctttgaagg
    18661 tgaactggta agaggttagt tttgtaacgt tcagtacatc tggaaagtct gttactaatc
    18721 ttgttgctag tttaccaact tcaattgctg ttgtagttga aagtttattt gtaccgttat
    18781 tcattccagt agcgtttaga aacggagatg gttgtgataa ctttagttgt tttgcttttt
    18841 cattcattag ctgagtgaaa ttatcttcgt ttccagcaat gtgttctgca agggcaagtg
    18901 tggaacgatt attccctgtc aataacaatg catgaagtaa atcacgaacc gttgttttat
    18961 ctttcgaagt tacttgtata ggactcgttt ctgctcggaa aacttcgtta cttattttta
    19021 ctacttcatc taactgtata tttcctttat ccagttgttc tagtacgata tattctgtca
    19081 ttaatttaga taaagtagcc gattgtatag aattttcttc atttttttta taaacaactt
    19141 cacctgaatt ggcatctatt aaaatagctg atttagcttg aataatggga ccatttacat
    19201 aaagataaaa atataaaacg ataagagcgg taataacaaa agataataat aaaattgtga
    19261 ttttttttaa gaattgcata agcgatcctc ctattatgac gtcgataata atattgtaaa
    19321 aaggaatact taattaggaa gaaagaaaag gtaaagaatt tctaaagaat tataaaggat
    19381 tattaaaatt tggatgttaa tggaaaatga aagatccaat ttcttatatc ataagaaatt
    19441 ggacctaaaa ttaagctgta ttaacattta tatggttgta gctttacagt gaatgttgtt
    19501 tttttgtcat cactatacac ttcaattgtt cctttatgca actctacaat actttttgca
    19561 attgccaatc cgagtccaga tccaccagtg tttgtagagc gcgatttctc aacgcgataa
    19621 aaacgttcga aaatatgagg taaatcggta cttggaatag gttggccata attggttata
    19681 tcgattgcga tcatattatt attttcataa gcagtaatat caatataatc accatcgtta
    19741 ccgtaagcga tagcgttaat aattagattt tcaaatacgc gcactaattt gtccccatca
    19801 gctaatacca ttaacttctt tgatgggaaa aaggggcgac aatcaatatt agcctcttga
    19861 agctgtattc gaaattgaac tgttaattgt ccaagaagtt ctacaatatc aatagggaca
    19921 gaatataaac ttaattcttt attttgaaca cgtgtatatt caaacaaatc attcattaat
    19981 gcattaagac gagttacttt gtcgtaaatg acttgtatat aatgccgtaa ttccacttca
    20041 tctctataat tatcatggtg gattaaattt acgtatccaa ctatagaggt aagaggtgta
    20101 cgtaaatcat gcgatacatt tgtaatcagt tcgctttttg cttgttctgc ctgtctttct
    20161 tcatcaatcg agactttcaa ttgttcaaca atttgattaa ccccgcttgc taactcttct
    20221 agataattat ggtttacgat agaaacttta tgattgaagt ttccatttgc aatatagcga
    20281 atctcttcta tcattttttt aatacaagtt tcatagtaaa gctttctttc atgacgataa
    20341 aaaatgtata ggtaggatga gaaaatagaa aataaaaata aataagagac aatcatcatc
    20401 catagagatt cttttattcc tttatatttt tcataaccaa aaatcctaat gaattctttg
    20461 ccaagttcgc ttaacgtaag cgaactctcg attacactcg taacgaggcg atatataatt
    20521 aattcagtaa taggagtgag tgtgatagct aataagagcc aaaaaataag tttccatttc
    20581 gggatatctt ttaatatatc aaatgcttca tttctcaatt ttatagccta ctccccaaac
    20641 agtatgaata aatttttctc cattcattcc tgtttcaagc ttatctcgta aattactaat
    20701 gtggaccatt acagttttat ttgaaccata accatcttca ttccaaacac gctcaaatat
    20761 ttcttcagaa ctaaatactc ttcctgtatt actcgcaagt aaatataaaa tatcaaattc
    20821 aatagatgta agcttaatat attctccatt tactttcaca gtatgattat gtttgtgtat
    20881 ttcagcggaa cgaatgcgaa tcataccatc ttcatttttg ggagaagaag cattttggaa
    20941 agatgatcgt cgaagcaaag ctttcactct agctactaat tctaatggat taaatggttt
    21001 aatcatataa tcatcggcgc ctgtcataag tcctaatatt ttatccatat cttctgcttt
    21061 tgcactcagc ataagaatag gtacagtatt attttcacga acttcttggc aaacttctaa
    21121 tccatttcgt tttggcatca taatatccaa aatcataagg tcaacttcat atgtagaaat
    21181 catttgtaat gcttcatcac catcatatgc tttataaatg ttatagcctt catttcgcaa
    21241 ataaacagca agtaattcga caatttcttt atcatcatca ataattaata tatttttatt
    21301 cattatgtag ttcctttcct tacaaatcat taacattact ataatatcaa acatttatgt
    21361 atttgtagcg atgattctgt ataaaatttc atgtaacgta ttaaaaaagg gattacaaca
    21421 tttataacga atacaaataa aaaggatatt taaatacaac gttatattga aagttaggaa
    21481 gaaggggaca tacgatgtta tataaggata tatattcatt tactccaact ggaaagattg
    21541 aaactgatat aaaagctttt ctattaaaat acaataaaga agttacatat aaacattcaa
    21601 ttcgagtggc aaatgagtct cgtaaaattg cggttatgta tcatgtaaat gaagaaaagg
    21661 cagcaattgc gggatattta catgatatta gtgcaatttt tccaaatgaa gtacggatta
    21721 cagttgctga agaatttgga atagatttat tagaagaaga acgaaaattc ccaatgatta
    21781 ttcatcaaaa actttcgaga gtactcgcaa aagagatatt taaagtgcat gatgaagaga
    21841 ctttaaatgc aatttgttgc cataccacac tacgtaaaca tgcaacgaag atggatttag
    21901 tgttatttgt tgctgataaa atagaatggg atcaaaatgg gacaccacca tacttagtag
    21961 aggtaaaaaa ggggttagaa aaatctttag aacatgcggc ttttgcatat atttcatatt
    22021 tgtgggatag aaaagacacg ttgaaagttt tacacccttg gctagaagat gcatattggc
    22081 agttaaaaga aattgtagag tagaaagaat ataaaataca gttaaaagaa tatatgaatg
    22141 aaatatttac tggtgttaca ttagtaccat acaaataata aacacttatt tgaagatata
    22201 tttttaaaag aagataaagt gtttttaata gcaaatgttt attggcttaa aaagggaaat
    22261 gtaaaaaatc cacagaaaat aaatatatag tcgatttatt caaaaaagat atttaaagta
    22321 tcatacaaga caaaaaacaa tactttttta tttgaagatg aagaaactac cttgtattgt
    22381 acatatcaat tttcattaaa atatttcgct ggtgatataa agtataaaag atttattcaa
    22441 gcagcgaatc atgaagattt accaggtctt tatcctagtt taggacgcaa aaaagaaatt
    22501 tcttatccag atgtatttct cataaatgca acaaaagata ttatcatgtt tatgtatgat
    22561 gatagaggaa gtgaagtaat ttcgaagaat aaagaaacaa tacgaaattt atatgagaaa
    22621 tataaagagt ggattccaga ttataaaaga gaaagcatag ataaattatt taaatgacag
    22681 tgagggaagt gaagtttgta atgaaacgta ttgcaatcgt agctgcttgg gaacctgaac
    22741 ttacgtattt gcatcaatct tatccaagtg aacgcattga aaaaagagcc gcttgggaat
    22801 ttcattttca tactataaat gatctggaaa ttatttcagt tataactggt gttgggaagg
    22861 taagttgtgc tagttgtgca caattattaa ttagtgagtt tcagccagat gagttgttta
    22921 tgacagggat atgcgggagt ttatcaacta aggtgaaaaa tggtcatatt gtagtggcac
    22981 taaacgccat acaacacgat gtcactgctg ctggttcggg cgaagatgtt tttaacttat
    23041 ataatggtag aacagcacct attgaaacaa caaaatcgct tgtaagaaga ataaaaaaaa
    23101 tacgatctta tgatccgatt catttcggga catttttatc tggagatcaa cgtatccgta
    23161 gttcagaaat gaggtattta ctccatactg tatatggagc attagctgtt gatcaagaag
    23221 tcgcagcttt tgcttatgta tgtcaaatca ataagaagcc ttttttatgt ttaaaagctg
    23281 cttcagatca agcaaatgat aaaacgaaag aggaacaaaa aatatttaaa atgttagcat
    23341 gtgaacgagc ttgcgagcat ttaattgctt ttttacgtgt gtatgaaatc aatgtagtaa
    23401 atcatagata gtaagagggg cttaatattg gaaagtacaa ataaaatagc tattttgggt
    23461 gcgaacggaa aagctggaaa aattcttgta aatgaagcgt tagaaaaggg atatcaagta
    23521 aaaatattaa cgagaaactc tacaaataca gagaaaataa ataaaaatat agagactatt
    23581 attggggacg cacgtaactt ttcaacgata caagacttac ttcaaggttg tagtgctgta
    23641 attaatgcag taggtcaacc gaaaaatgaa tcttacattt ttagtacagt aacgaagcat
    23701 attttagaag cgatgaaaga gtctaaaata aaaagatata ttctaatttc tggaggttct
    23761 ttaaatgtta cgggagatca gaagggaatt ataaataaaa taggagctac tttgtttaaa
    23821 ttgtttttac caaaaatgat gcaagataaa tataaagaat tacaaattat ccaaaatagt
    23881 gaggtagatt ggacaattgt tagattacca tttgttatag agggaaatgg tattggaagt
    23941 ataaaagaga gtttagttga tatgccagga atcaaaatac aaaatggcga tattgcaccg
    24001 tttgttataa aacaaattaa tagtgataga tatgtaggga agtgtccgtt catttcaaat
    24061 taagcagtag aattcaaaat taaagtatga tgtgactagt agatcttatg tatttgaacg
    24121 ttaagtttaa cgcgagtaag tgggggataa ttttatatga ttcaatataa aagatgcagt
    24181 gaaataaata tagatttagt gtatgaagct tttagggatg ggttttcaga ttatattatt
    24241 aagatggaag tttcaaaggg agattttata aaaagatttt ttggtcttga agggaattcg
    24301 ttagaacact cgtttcttgc tttagatggt gacaagccag ttggtgtaat acttggtggg
    24361 ataaaggatt atgaaaatat aaaaacaatg cgctgcggta cattagcggt tcatccgaat
    24421 tatcgtggtg ttggtgtgag tcaaaagtta tttgaactgc ataaagaaga ggcgcttcaa
    24481 aatgagtgta agcaactttt tcttgaagtc attgtaggta atgaccgagc gattcgtttt
    24541 tataataaat taggctatga aaaagtgtac gatctatctt attataattt aaaagatatg
    24601 actaaaataa tacatagaga atgtaaggga attgaagtaa aacaattaga atttgcagct
    24661 tttaaagttg aaattcagaa atggttacac ttccatataa actggcaaaa tgatatggat
    24721 tatatcgaaa aaacaaatca taccttttat ggtgcatatg tcgataatga tttaaaaggt
    24781 tctatatgta taaatgaaca aggtaaaatt agttttattt tcatagacaa agagtataga
    24841 aatcgtggta ttggatcaaa attattacaa gtagcaagag atgagttgaa tttagaaagc
    24901 ttattaatta gttttccaaa caacagttta ctagaagggt ttgtaaagaa aactggattt
    24961 gaaaagaatt ctttagcaca atatgaaatg tatgtattgc tgtaaaaagc ggaaggaaat
    25021 attctttcgc tttttatttt tgtactatat tgatatttta ctttgtataa tattcttttt
    25081 ttatgtaaaa tagataggat ggaggggatg aaatggataa tggattaaag tttaagattt
    25141 ttgaattgca ttgtttcgtt caaaagactt attctgatat gaaaatagca tgtgatattg
    25201 ctatttatca agaaaacact tctaaatatt taatttcat
//
