Select genomic region:
Overview
2.1
3.1
3.2
13.1
22.1
22.2
33.1
35.1
56.1
65.1
67.1

### Identified secondary metabolite regions using strictness 'relaxed'

c00002_NZ_JALC.. (original name was: NZ_JALCKS010000002.1)

Region | Type | From | To | Most similar known cluster | Similarity
--- | --- | --- | --- | --- | ---
Region 2.1 | betalactone | 87,813 | 117,444 |

c00003_NZ_JALC.. (original name was: NZ_JALCKS010000003.1)

Region | Type | From | To | Most similar known cluster | Similarity
--- | --- | --- | --- | --- | ---
Region 3.1 | ranthipeptide | 12,010 | 33,470 |
Region 3.2 | NRPS | 178,432 | 206,340 |

c00013_NZ_JALC.. (original name was: NZ_JALCKS010000013.1)

Region | Type | From | To | Most similar known cluster | Similarity
--- | --- | --- | --- | --- | ---
Region 13.1 | terpene | 1 | 15,093 |

c00022_NZ_JALC.. (original name was: NZ_JALCKS010000022.1)

Region | Type | From | To | Most similar known cluster | Similarity
--- | --- | --- | --- | --- | ---
Region 22.1 | NRPS | 1 | 52,633 |
Region 22.2 | proteusin | 53,954 | 74,274 |

c00033_NZ_JALC.. (original name was: NZ_JALCKS010000033.1)

Region | Type | From | To | Most similar known cluster | Similarity
--- | --- | --- | --- | --- | ---
Region 33.1 | T3PKS | 1,646 | 42,704 | molybdenum cofactor | Other | 11%

c00035_NZ_JALC.. (original name was: NZ_JALCKS010000035.1)

Region | Type | From | To | Most similar known cluster | Similarity
--- | --- | --- | --- | --- | ---
Region 35.1 | proteusin | 16,145 | 36,465 | S-layer glycan | Saccharide | 8%

c00056_NZ_JALC.. (original name was: NZ_JALCKS010000056.1)

Region | Type | From | To | Most similar known cluster | Similarity
--- | --- | --- | --- | --- | ---
Region 56.1 | NRPS | 1 | 28,596 | tyrocidine | NRP | 31%

c00065_NZ_JALC.. (original name was: NZ_JALCKS010000065.1)

Region | Type | From | To | Most similar known cluster | Similarity
--- | --- | --- | --- | --- | ---
Region 65.1 | LAP,RiPP-like | 1 | 19,791 |

c00067_NZ_JALC.. (original name was: NZ_JALCKS010000067.1)

Region | Type | From | To | Most similar known cluster | Similarity
--- | --- | --- | --- | --- | ---
Region 67.1 | cyclic-lactone-autoinducer | 1 | 16,490 |

Region | Type | From | To | Most similar known cluster | Similarity
--- | --- | --- | --- | --- | ---
Region 2.1 | betalactone | 87,813 | 117,444 |
Region 3.1 | ranthipeptide | 12,010 | 33,470 |
Region 3.2 | NRPS | 178,432 | 206,340 |
Region 13.1 | terpene | 1 | 15,093 |
Region 22.1 | NRPS | 1 | 52,633 |
Region 22.2 | proteusin | 53,954 | 74,274 |
Region 33.1 | T3PKS | 1,646 | 42,704 | molybdenum cofactor | Other | 11%
Region 35.1 | proteusin | 16,145 | 36,465 | S-layer glycan | Saccharide | 8%
Region 56.1 | NRPS | 1 | 28,596 | tyrocidine | NRP | 31%
Region 65.1 | LAP,RiPP-like | 1 | 19,791 |
Region 67.1 | cyclic-lactone-autoinducer | 1 | 16,490 |

No secondary metabolite regions were found in these records:
  c00001_NZ_JALC.. (original name was: NZ_JALCKS010000001.1)
  c00004_NZ_JALC.. (original name was: NZ_JALCKS010000004.1)
  c00005_NZ_JALC.. (original name was: NZ_JALCKS010000005.1)
  c00006_NZ_JALC.. (original name was: NZ_JALCKS010000006.1)
  c00007_NZ_JALC.. (original name was: NZ_JALCKS010000007.1)
  c00008_NZ_JALC.. (original name was: NZ_JALCKS010000008.1)
  c00009_NZ_JALC.. (original name was: NZ_JALCKS010000009.1)
  c00010_NZ_JALC.. (original name was: NZ_JALCKS010000010.1)
  c00011_NZ_JALC.. (original name was: NZ_JALCKS010000011.1)
  c00012_NZ_JALC.. (original name was: NZ_JALCKS010000012.1)
  c00014_NZ_JALC.. (original name was: NZ_JALCKS010000014.1)
  c00015_NZ_JALC.. (original name was: NZ_JALCKS010000015.1)
  c00016_NZ_JALC.. (original name was: NZ_JALCKS010000016.1)
  c00017_NZ_JALC.. (original name was: NZ_JALCKS010000017.1)
  c00018_NZ_JALC.. (original name was: NZ_JALCKS010000018.1)
  c00019_NZ_JALC.. (original name was: NZ_JALCKS010000019.1)
  c00020_NZ_JALC.. (original name was: NZ_JALCKS010000020.1)
  c00021_NZ_JALC.. (original name was: NZ_JALCKS010000021.1)
  c00023_NZ_JALC.. (original name was: NZ_JALCKS010000023.1)
  c00024_NZ_JALC.. (original name was: NZ_JALCKS010000024.1)
  c00025_NZ_JALC.. (original name was: NZ_JALCKS010000025.1)
  c00026_NZ_JALC.. (original name was: NZ_JALCKS010000026.1)
  c00027_NZ_JALC.. (original name was: NZ_JALCKS010000027.1)
  c00028_NZ_JALC.. (original name was: NZ_JALCKS010000028.1)
  c00029_NZ_JALC.. (original name was: NZ_JALCKS010000029.1)
  c00030_NZ_JALC.. (original name was: NZ_JALCKS010000030.1)
  c00031_NZ_JALC.. (original name was: NZ_JALCKS010000031.1)
  c00032_NZ_JALC.. (original name was: NZ_JALCKS010000032.1)
  c00034_NZ_JALC.. (original name was: NZ_JALCKS010000034.1)
  c00036_NZ_JALC.. (original name was: NZ_JALCKS010000036.1)
  c00037_NZ_JALC.. (original name was: NZ_JALCKS010000037.1)
  c00038_NZ_JALC.. (original name was: NZ_JALCKS010000038.1)
  c00039_NZ_JALC.. (original name was: NZ_JALCKS010000039.1)
  c00040_NZ_JALC.. (original name was: NZ_JALCKS010000040.1)
  c00041_NZ_JALC.. (original name was: NZ_JALCKS010000041.1)
  c00042_NZ_JALC.. (original name was: NZ_JALCKS010000042.1)
  c00043_NZ_JALC.. (original name was: NZ_JALCKS010000043.1)
  c00044_NZ_JALC.. (original name was: NZ_JALCKS010000044.1)
  c00045_NZ_JALC.. (original name was: NZ_JALCKS010000045.1)
  c00046_NZ_JALC.. (original name was: NZ_JALCKS010000046.1)
  c00047_NZ_JALC.. (original name was: NZ_JALCKS010000047.1)
  c00048_NZ_JALC.. (original name was: NZ_JALCKS010000048.1)
  c00049_NZ_JALC.. (original name was: NZ_JALCKS010000049.1)
  c00050_NZ_JALC.. (original name was: NZ_JALCKS010000050.1)
  c00051_NZ_JALC.. (original name was: NZ_JALCKS010000051.1)
  c00052_NZ_JALC.. (original name was: NZ_JALCKS010000052.1)
  c00053_NZ_JALC.. (original name was: NZ_JALCKS010000053.1)
  c00054_NZ_JALC.. (original name was: NZ_JALCKS010000054.1)
  c00055_NZ_JALC.. (original name was: NZ_JALCKS010000055.1)
  c00057_NZ_JALC.. (original name was: NZ_JALCKS010000057.1)
  c00058_NZ_JALC.. (original name was: NZ_JALCKS010000058.1)
  c00059_NZ_JALC.. (original name was: NZ_JALCKS010000059.1)
  c00060_NZ_JALC.. (original name was: NZ_JALCKS010000060.1)
  c00061_NZ_JALC.. (original name was: NZ_JALCKS010000061.1)
  c00062_NZ_JALC.. (original name was: NZ_JALCKS010000062.1)
  c00063_NZ_JALC.. (original name was: NZ_JALCKS010000063.1)
  c00064_NZ_JALC.. (original name was: NZ_JALCKS010000064.1)
  c00066_NZ_JALC.. (original name was: NZ_JALCKS010000066.1)
  c00068_NZ_JALC.. (original name was: NZ_JALCKS010000068.1)
  c00069_NZ_JALC.. (original name was: NZ_JALCKS010000069.1)
  c00070_NZ_JALC.. (original name was: NZ_JALCKS010000070.1)
  c00071_NZ_JALC.. (original name was: NZ_JALCKS010000071.1)
  c00072_NZ_JALC.. (original name was: NZ_JALCKS010000072.1)
  c00073_NZ_JALC.. (original name was: NZ_JALCKS010000073.1)
  c00074_NZ_JALC.. (original name was: NZ_JALCKS010000074.1)
  c00075_NZ_JALC.. (original name was: NZ_JALCKS010000075.1)
  c00076_NZ_JALC.. (original name was: NZ_JALCKS010000076.1)
  c00077_NZ_JALC.. (original name was: NZ_JALCKS010000077.1)
  c00078_NZ_JALC.. (original name was: NZ_JALCKS010000078.1)
  c00079_NZ_JALC.. (original name was: NZ_JALCKS010000079.1)
  c00080_NZ_JALC.. (original name was: NZ_JALCKS010000080.1)
  c00081_NZ_JALC.. (original name was: NZ_JALCKS010000081.1)
  c00082_NZ_JALC.. (original name was: NZ_JALCKS010000082.1)
  c00083_NZ_JALC.. (original name was: NZ_JALCKS010000083.1)
  c00084_NZ_JALC.. (original name was: NZ_JALCKS010000084.1)
  c00085_NZ_JALC.. (original name was: NZ_JALCKS010000085.1)
  c00086_NZ_JALC.. (original name was: NZ_JALCKS010000086.1)
  c00087_NZ_JALC.. (original name was: NZ_JALCKS010000087.1)
  c00088_NZ_JALC.. (original name was: NZ_JALCKS010000088.1)
  c00089_NZ_JALC.. (original name was: NZ_JALCKS010000089.1)
  c00090_NZ_JALC.. (original name was: NZ_JALCKS010000090.1)
  c00091_NZ_JALC.. (original name was: NZ_JALCKS010000091.1)
  c00092_NZ_JALC.. (original name was: NZ_JALCKS010000092.1)
  c00093_NZ_JALC.. (original name was: NZ_JALCKS010000093.1)
  c00094_NZ_JALC.. (original name was: NZ_JALCKS010000094.1)

Compact view
c00002_NZ_JALC.. - Region 1 - betalactone
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 87,813 - 117,444 nt. (total: 29,632 nt) Show pHMM detection rules used
betalactone: (HMGL-like and AMP-binding)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
MIBiG comparison
KnownClusterBlast
Pfam domains
TIGRFAM domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | betalactone | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000234.1 |  | 0.19 | Polyketide | jadomycin | Streptomyces venezuelae ATCC 10712
BGC0001808.1 |  | 0.17 | Other | toyocamycin | Streptomyces diastatochromogenes
BGC0000881.1 |  | 0.17 | Other | toyocamycin | Streptomyces ahygroscopicus subsp. wuzhouensis
BGC0000879.1 |  | 0.17 | Other | toyocamycin, sangivamycin | Streptomyces rimosus
BGC0001937.1 |  | 0.17 | Other | tubercidin | Streptomyces tubercidicus
BGC0000938.1 |  | 0.16 | Other (Aminocoumarin) | fosfomycin | Streptomyces fradiae
BGC0000554.1 |  | 0.16 | RiPP | SRO15-3108 | Streptomyces filamentosus NRRL 15998
BGC0001241.1 |  | 0.16 | Terpene | ergotamine | Claviceps fusiformis
BGC0001267.1 |  | 0.16 | Terpene | lysergic acid, elymoclavine | Claviceps fusiformis
BGC0001391.1 |  | 0.16 | RiPP | thusin | Bacillus thuringiensis serovar rongseni

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000234.1 |  | 0.51 | Polyketide | jadomycin | Streptomyces venezuelae ATCC 10712
BGC0001808.1 |  | 0.49 | Other | toyocamycin | Streptomyces diastatochromogenes
BGC0000881.1 |  | 0.49 | Other | toyocamycin | Streptomyces ahygroscopicus subsp. wuzhouensis
BGC0000879.1 |  | 0.49 | Other | toyocamycin, sangivamycin | Streptomyces rimosus
BGC0001937.1 |  | 0.48 | Other | tubercidin | Streptomyces tubercidicus
BGC0000938.1 |  | 0.47 | Other (Aminocoumarin) | fosfomycin | Streptomyces fradiae
BGC0000554.1 |  | 0.47 | RiPP | SRO15-3108 | Streptomyces filamentosus NRRL 15998
BGC0001241.1 |  | 0.47 | Terpene | ergotamine | Claviceps fusiformis
BGC0001267.1 |  | 0.47 | Terpene | lysergic acid, elymoclavine | Claviceps fusiformis
BGC0001391.1 |  | 0.46 | RiPP | thusin | Bacillus thuringiensis serovar rongseni

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.

No matches found.

Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
c00003_NZ_JALC.. - Region 1 - ranthipeptide
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 12,010 - 33,470 nt. (total: 21,461 nt) Show pHMM detection rules used
ranthipeptide: (TIGR03973 or SCIFF or (cds(PF04055 and (TIGR04085 or SPASM)) and minimum(1, [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE, Cytolysin_C_RRE, Goadsporin_CD_RRE, Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE, Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE, Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE, Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE, Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE, Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE, Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE, Thiaglutamate_B_RRE, Thiaglutamate_G_RRE, Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE, Thurincin_rSAM_RRE, Trifolitoxin_RRE]) and not (TIGR01716 or subtilosin or TIGR02111 or TIGR03966 or TIGR04103 or YcaO or TIGR03882)))

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
MIBiG comparison
KnownClusterBlast
Pfam domains
TIGRFAM domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | ranthipeptide | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000928.1 |  | 0.16 | Other | T3 toxin | Cylindrospermopsis raciborskii T3
BGC0000188.1 |  | 0.16 | Alkaloid | saxitoxin, neosaxitoxin, decarbamoylsaxitoxin, gonyautoxin 3, gonyautoxin 2 | Cylindrospermopsis raciborskii T3
BGC0000486.1 |  | 0.16 | RiPP | butyrivibriocin AR10 | Butyrivibrio fibrisolvens
BGC0001787.1 |  | 0.16 | RiPP | suicin 3908 | Streptococcus suis
BGC0000498.1 |  | 0.16 | RiPP | bovicin HJ50 | Streptococcus equinus
BGC0000561.1 |  | 0.16 | RiPP | thermophilin 1277 | Streptococcus thermophilus
BGC0000626.1 |  | 0.16 | RiPP | thuricin | Bacillus thuringiensis
BGC0000602.1 |  | 0.15 | RiPP | subtilosin A | Bacillus subtilis subsp. spizizenii ATCC 6633
BGC0001222.1 |  | 0.15 | RiPP | acidocin B | Lactobacillus acidophilus
BGC0000491.1 |  | 0.15 | RiPP | gassericin A | Lactobacillus gasseri

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000928.1 |  | 0.47 | Other | T3 toxin | Cylindrospermopsis raciborskii T3
BGC0000188.1 |  | 0.47 | Alkaloid | saxitoxin, neosaxitoxin, decarbamoylsaxitoxin, gonyautoxin 3, gonyautoxin 2 | Cylindrospermopsis raciborskii T3
BGC0000486.1 |  | 0.46 | RiPP | butyrivibriocin AR10 | Butyrivibrio fibrisolvens
BGC0001787.1 |  | 0.46 | RiPP | suicin 3908 | Streptococcus suis
BGC0000498.1 |  | 0.46 | RiPP | bovicin HJ50 | Streptococcus equinus
BGC0000561.1 |  | 0.46 | RiPP | thermophilin 1277 | Streptococcus thermophilus
BGC0000626.1 |  | 0.46 | RiPP | thuricin | Bacillus thuringiensis
BGC0000602.1 |  | 0.46 | RiPP | subtilosin A | Bacillus subtilis subsp. spizizenii ATCC 6633
BGC0001222.1 |  | 0.45 | RiPP | acidocin B | Lactobacillus acidophilus
BGC0000491.1 |  | 0.45 | RiPP | gassericin A | Lactobacillus gasseri

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.

No matches found.

Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
c00003_NZ_JALC.. - Region 2 - NRPS
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 178,432 - 206,340 nt. (total: 27,909 nt) Show pHMM detection rules used
Region on contig edge.
NRPS: cds(Condensation and (AMP-binding or A-OX))

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
NRPS/PKS domains
MIBiG comparison
KnownClusterBlast
NRPS/PKS modules
Pfam domains
TIGRFAM domains
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
A glossary is available here.
Selected features only
Show module domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | NRPS | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001399.1 |  | 0.30 | NRP | fellutamide B | Aspergillus nidulans FGSC A4
BGC0001479.1 |  | 0.22 | NRP | anabaenopeptin NZ857, nostamide A | Nostoc punctiforme PCC 73102
BGC0000427.1 |  | 0.22 | NRP | shinorine, 4-deoxygadusol, mycosporine glycine | Trichormus variabilis ATCC 29413
BGC0001128.1 |  | 0.22 | NRP | luminmide | Photorhabdus laumondii subsp. laumondii TTO1
BGC0001833.1 |  | 0.22 | NRP | icosalide A, icosalide B | Burkholderia gladioli
BGC0001135.1 |  | 0.21 | NRP | bicornutin A1, bicornutin A2 | Xenorhabdus budapestensis
BGC0001641.1 |  | 0.21 | NRP | kolossin | Photorhabdus laumondii subsp. laumondii TTO1
BGC0001758.1 |  | 0.21 | NRP | rhizomide A, rhizomide B, rhizomide C | Paraburkholderia rhizoxinica HKI 454
BGC0001615.1 |  | 0.21 | NRP | hexose-palythine-serine, hexose-shinorine | Heteroscytonema crispum UCFS10
BGC0001131.1 |  | 0.21 | NRP | ambactin | Xenorhabdus miraniensis

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001399.1 |  | 0.64 | NRP | fellutamide B | Aspergillus nidulans FGSC A4
BGC0001479.1 |  | 0.55 | NRP | anabaenopeptin NZ857, nostamide A | Nostoc punctiforme PCC 73102
BGC0000427.1 |  | 0.55 | NRP | shinorine, 4-deoxygadusol, mycosporine glycine | Trichormus variabilis ATCC 29413
BGC0001128.1 |  | 0.55 | NRP | luminmide | Photorhabdus laumondii subsp. laumondii TTO1
BGC0001833.1 |  | 0.55 | NRP | icosalide A, icosalide B | Burkholderia gladioli
BGC0001135.1 |  | 0.54 | NRP | bicornutin A1, bicornutin A2 | Xenorhabdus budapestensis
BGC0001641.1 |  | 0.54 | NRP | kolossin | Photorhabdus laumondii subsp. laumondii TTO1
BGC0001758.1 |  | 0.54 | NRP | rhizomide A, rhizomide B, rhizomide C | Paraburkholderia rhizoxinica HKI 454
BGC0001615.1 |  | 0.54 | NRP | hexose-palythine-serine, hexose-shinorine | Heteroscytonema crispum UCFS10
BGC0001131.1 |  | 0.54 | NRP | ambactin | Xenorhabdus miraniensis

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.

No matches found.

Module view
Shows module structures for each candidate in NRPS- and PKS regions. Genes are shown in predicted order, and are only present when containing at least one complete module. A domain glossary is available here.
Legend
Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
NRPS/PKS products
NRPS/PKS monomers
Predicted core structure(s)
Shows estimated product structure and polymer for each candidate cluster in the region. To show the product, click on the expander or the candidate cluster feature drawn in the overview.
For candidate cluster 2, location 178431 - 206340:
Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:
  (tyr)

Direct lookup in NORINE database: strict or relaxed
Link to NORINE database query form
NRPS/PKS monomer predictions
Shows the predicted monomers for each adynelation domain and acyltransferase within genes. Each gene prediction can be expanded to view detailed predictions of each domain. Each prediction can be expanded to view the predictions by tool (and, for some tools, further expanded for extra details).

ctg3_171: tyr
  Search NORINE for peptide: strict or relaxed
  AMP-binding (257..667): tyr
  NRPSPredictor2: tyr
  SVM prediction details:
    Predicted physicochemical class:
      hydrophobic-aromatic
    Large clusters prediction:
      phe, trp, phg, tyr, bht
    Small clusters prediction:
      N/A
    Single AA prediction:
      tyr
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DAaAIAAVgK
    Nearest Stachelhaus code:
      phe
    Stachelhaus code match:
      80% (moderate)
ctg3_173: leu
  Search NORINE for peptide: strict or relaxed
  AMP-binding (8..409): leu
  NRPSPredictor2: leu
  SVM prediction details:
    Predicted physicochemical class:
      hydrophobic-aliphatic
    Large clusters prediction:
      gly, ala, val, leu, ile, abu, iva
    Small clusters prediction:
      val, leu, ile, abu, iva
    Single AA prediction:
      leu
  Stachelhaus prediction details:
    Stachelhaus sequence:
      hcaftGLpGK
    Nearest Stachelhaus code:
      phg
    Stachelhaus code match:
      40% (weak)

c00013_NZ_JALC.. - Region 1 - terpene
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 1 - 15,093 nt. (total: 15,093 nt) Show pHMM detection rules used
Region on contig edge.
terpene: (Terpene_synth or Terpene_synth_C or phytoene_synt or Lycopene_cycl or terpene_cyclase or NapT7 or fung_ggpps or fung_ggpps2 or trichodiene_synth or TRI5)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
MIBiG comparison
KnownClusterBlast
Pfam domains
TIGRFAM domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | terpene | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001839.1 |  | 0.32 | Terpene | squalestatin S1 | Aspergillus sp. Z5
BGC0000888.1 |  | 0.16 | Other | bacilysin | Bacillus sp. CS93
BGC0001138.1 |  | 0.15 | Other (Nucleoside) | a201a | Marinactinospora thermotolerans
BGC0000207.1 |  | 0.15 | Polyketide | chartreusin | Streptomyces chartreusis
BGC0001184.1 |  | 0.15 | Other | bacilysin | Bacillus velezensis FZB42
BGC0000698.1 |  | 0.15 | Saccharide | hygromycin A | Streptomyces hygroscopicus
BGC0001917.1 |  | 0.15 | Polyketide | 5-alkyl-1,2,3,4-tetrahydroquinolines, streptoaminals | Streptomyces nigrescens
BGC0000265.1 |  | 0.15 | Polyketide | rhodomycin | Streptomyces purpurascens
BGC0000867.1 |  | 0.15 | Other | polyhydroxyalkanoic acids | Ectothiorhodospira shaposhnikovii
BGC0000010.1 |  | 0.15 | Polyketide | aflatoxin | Aspergillus flavus

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001839.1 |  | 0.65 | Terpene | squalestatin S1 | Aspergillus sp. Z5
BGC0000888.1 |  | 0.47 | Other | bacilysin | Bacillus sp. CS93
BGC0001138.1 |  | 0.46 | Other (Nucleoside) | a201a | Marinactinospora thermotolerans
BGC0000207.1 |  | 0.46 | Polyketide | chartreusin | Streptomyces chartreusis
BGC0001184.1 |  | 0.45 | Other | bacilysin | Bacillus velezensis FZB42
BGC0000698.1 |  | 0.45 | Saccharide | hygromycin A | Streptomyces hygroscopicus
BGC0001917.1 |  | 0.45 | Polyketide | 5-alkyl-1,2,3,4-tetrahydroquinolines, streptoaminals | Streptomyces nigrescens
BGC0000265.1 |  | 0.45 | Polyketide | rhodomycin | Streptomyces purpurascens
BGC0000867.1 |  | 0.44 | Other | polyhydroxyalkanoic acids | Ectothiorhodospira shaposhnikovii
BGC0000010.1 |  | 0.44 | Polyketide | aflatoxin | Aspergillus flavus

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.

No matches found.

Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
c00022_NZ_JALC.. - Region 1 - NRPS
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 1 - 52,633 nt. (total: 52,633 nt) Show pHMM detection rules used
Region on contig edge.
NRPS: cds(Condensation and (AMP-binding or A-OX))

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
NRPS/PKS domains
MIBiG comparison
KnownClusterBlast
NRPS/PKS modules
Pfam domains
TIGRFAM domains
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
A glossary is available here.
Selected features only
Show module domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | NRPS | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000389.1 |  | 0.26 | NRP | massetolide A | Pseudomonas fluorescens SS101
BGC0001538.1 |  | 0.25 | NRP, Polyketide | caboxamycin | Streptomyces sp. NTK 937
BGC0001444.1 |  | 0.22 | Other | caboxamycin | Streptomyces sp. NTK 937
BGC0001636.1 |  | 0.22 | NRP | KK-1 | Curvularia clavata
BGC0001699.1 |  | 0.21 | Polyketide | nidulanin A | Aspergillus nidulans FGSC A4
BGC0001343.1 |  | 0.21 | Polyketide | aurachin A, aurachin D | Stigmatella aurantiaca Sg a15
BGC0001591.1 |  | 0.21 | Other | fatty acid enol ester | uncultured bacterium CSLC2
BGC0001688.1 |  | 0.21 | Other | N-tetradecanoyl tyrosine | uncultured bacterium CSLC2
BGC0001615.1 |  | 0.21 | NRP | hexose-palythine-serine, hexose-shinorine | Heteroscytonema crispum UCFS10
BGC0001220.1 |  | 0.21 | NRP | aculeacin A | Aspergillus japonicus

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000389.1 |  | 0.60 | NRP | massetolide A | Pseudomonas fluorescens SS101
BGC0001538.1 |  | 0.58 | NRP, Polyketide | caboxamycin | Streptomyces sp. NTK 937
BGC0001444.1 |  | 0.55 | Other | caboxamycin | Streptomyces sp. NTK 937
BGC0001636.1 |  | 0.55 | NRP | KK-1 | Curvularia clavata
BGC0001699.1 |  | 0.54 | Polyketide | nidulanin A | Aspergillus nidulans FGSC A4
BGC0001343.1 |  | 0.54 | Polyketide | aurachin A, aurachin D | Stigmatella aurantiaca Sg a15
BGC0001591.1 |  | 0.54 | Other | fatty acid enol ester | uncultured bacterium CSLC2
BGC0001688.1 |  | 0.54 | Other | N-tetradecanoyl tyrosine | uncultured bacterium CSLC2
BGC0001615.1 |  | 0.53 | NRP | hexose-palythine-serine, hexose-shinorine | Heteroscytonema crispum UCFS10
BGC0001220.1 |  | 0.53 | NRP | aculeacin A | Aspergillus japonicus

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.

No matches found.

Module view
Shows module structures for each candidate in NRPS- and PKS regions. Genes are shown in predicted order, and are only present when containing at least one complete module. A domain glossary is available here.
Legend
Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
NRPS/PKS products
NRPS/PKS monomers
Predicted core structure(s)
Shows estimated product structure and polymer for each candidate cluster in the region. To show the product, click on the expander or the candidate cluster feature drawn in the overview.
For candidate cluster 1, location 0 - 52633:
Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:
  (Me-cys - Me-cys) + (Me-cys)

Direct lookup in NORINE database: strict or relaxed
Link to NORINE database query form
NRPS/PKS monomer predictions
Shows the predicted monomers for each adynelation domain and acyltransferase within genes. Each gene prediction can be expanded to view detailed predictions of each domain. Each prediction can be expanded to view the predictions by tool (and, for some tools, further expanded for extra details).

ctg22_12: cys
  Search NORINE for peptide: strict or relaxed
  AMP-binding (538..933): cys
  NRPSPredictor2: cys
  SVM prediction details:
    Predicted physicochemical class:
      hydrophobic-aliphatic
    Large clusters prediction:
      cys
    Small clusters prediction:
      cys
    Single AA prediction:
      cys
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DLYNLSLIWK
    Nearest Stachelhaus code:
      cys
    Stachelhaus code match:
      100% (strong)
ctg22_15: cys - cys
  Search NORINE for peptide: strict or relaxed
  AMP-binding (568..967): cys
  NRPSPredictor2: cys
  SVM prediction details:
    Predicted physicochemical class:
      hydrophobic-aliphatic
    Large clusters prediction:
      cys
    Small clusters prediction:
      cys
    Single AA prediction:
      cys
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DLYNMSMIWK
    Nearest Stachelhaus code:
      cys
    Stachelhaus code match:
      100% (strong)
  AMP-binding (2036..2437): cys
  NRPSPredictor2: cys
  SVM prediction details:
    Predicted physicochemical class:
      hydrophobic-aliphatic
    Large clusters prediction:
      cys
    Small clusters prediction:
      cys
    Single AA prediction:
      cys
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DLYNLSLIWK
    Nearest Stachelhaus code:
      cys
    Stachelhaus code match:
      100% (strong)
ctg22_16: dhb
  Search NORINE for peptide: strict or relaxed
  AMP-binding (32..435): dhb
  NRPSPredictor2: dhb
  SVM prediction details:
    Predicted physicochemical class:
      hydrophobic-aromatic
    Large clusters prediction:
      dhb, sal
    Small clusters prediction:
      dhb, sal
    Single AA prediction:
      dhb
  Stachelhaus prediction details:
    Stachelhaus sequence:
      PLPAQGViCK
    Nearest Stachelhaus code:
      dhb
    Stachelhaus code match:
      90% (moderate)

c00022_NZ_JALC.. - Region 2 - proteusin
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 53,954 - 74,274 nt. (total: 20,321 nt) Show pHMM detection rules used
proteusin: (PoyD or TIGR03793)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
MIBiG comparison
KnownClusterBlast
Pfam domains
TIGRFAM domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | proteusin | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001120.1 |  | 0.13 | NRP, Polyketide | burkholderic acid | Burkholderia thailandensis E264
BGC0001596.1 |  | 0.11 | Polyketide | fluostatins M-Q | Streptomyces albus
BGC0001636.1 |  | 0.09 | NRP | KK-1 | Curvularia clavata
BGC0000937.1 |  | 0.09 | Other | fosfazinomycin A | Streptomyces sp. WM6372
BGC0001669.1 |  | 0.09 | RiPP | microvionin | Microbacterium arborescens
BGC0001497.1 |  | 0.07 | Polyketide | actinonin | Streptomyces sp.
BGC0001442.1 |  | 0.07 | NRP | actinonin | Streptomyces sp. strain ATCC 14903
BGC0001580.1 |  | 0.07 | Polyketide | ebelactone | Kitasatospora aburaviensis
BGC0000350.1 |  | 0.06 | NRP | ET-743 | uncultured organism
BGC0000609.1 |  | 0.06 | RiPP | nocathiacin | Nocardia sp. ATCC 202099

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001120.1 |  | 0.42 | NRP, Polyketide | burkholderic acid | Burkholderia thailandensis E264
BGC0001596.1 |  | 0.38 | Polyketide | fluostatins M-Q | Streptomyces albus
BGC0001636.1 |  | 0.34 | NRP | KK-1 | Curvularia clavata
BGC0000937.1 |  | 0.33 | Other | fosfazinomycin A | Streptomyces sp. WM6372
BGC0001669.1 |  | 0.33 | RiPP | microvionin | Microbacterium arborescens
BGC0001497.1 |  | 0.29 | Polyketide | actinonin | Streptomyces sp.
BGC0001442.1 |  | 0.29 | NRP | actinonin | Streptomyces sp. strain ATCC 14903
BGC0001580.1 |  | 0.28 | Polyketide | ebelactone | Kitasatospora aburaviensis
BGC0000350.1 |  | 0.27 | NRP | ET-743 | uncultured organism
BGC0000609.1 |  | 0.27 | RiPP | nocathiacin | Nocardia sp. ATCC 202099

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.

No matches found.

Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
c00033_NZ_JALC.. - Region 1 - T3PKS
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 1,646 - 42,704 nt. (total: 41,059 nt) Show pHMM detection rules used
T3PKS: (Chal_sti_synt_C or Chal_sti_synt_N)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
NRPS/PKS domains
MIBiG comparison
KnownClusterBlast
Pfam domains
TIGRFAM domains
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
A glossary is available here.
Selected features only
Show module domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | T3PKS | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000282.1 |  | 0.27 | Polyketide | alkylresorcinol | Streptomyces griseus subsp. griseus NBRC 13350
BGC0001962.1 |  | 0.24 | Polyketide | hierridin B, hierridin C | Cyanobium sp. LEGE 06113
BGC0001938.1 |  | 0.23 | Polyketide | entotheonella | Candidatus Entotheonella serta
BGC0001535.1 |  | 0.22 | Other | branched-chain fatty acids | Streptomyces filamentosus
BGC0001831.1 |  | 0.20 | Polyketide | alkylpyrone-407, alkylpyrone-393 | Myxococcus xanthus DK 1622
BGC0000867.1 |  | 0.18 | Other | polyhydroxyalkanoic acids | Ectothiorhodospira shaposhnikovii
BGC0000866.1 |  | 0.18 | Other | polyhydroxyalkanoate | Burkholderia sp. DSM 9242
BGC0001589.1 |  | 0.17 | Saccharide | exopolysaccharides | Burkholderia cenocepacia J2315
BGC0001588.1 |  | 0.17 | Saccharide | exopolysaccharides | Burkholderia pseudomallei 1026b
BGC0000626.1 |  | 0.16 | RiPP | thuricin | Bacillus thuringiensis

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000282.1 |  | 0.60 | Polyketide | alkylresorcinol | Streptomyces griseus subsp. griseus NBRC 13350
BGC0001962.1 |  | 0.57 | Polyketide | hierridin B, hierridin C | Cyanobium sp. LEGE 06113
BGC0001938.1 |  | 0.56 | Polyketide | entotheonella | Candidatus Entotheonella serta
BGC0001535.1 |  | 0.55 | Other | branched-chain fatty acids | Streptomyces filamentosus
BGC0001831.1 |  | 0.52 | Polyketide | alkylpyrone-407, alkylpyrone-393 | Myxococcus xanthus DK 1622
BGC0000867.1 |  | 0.49 | Other | polyhydroxyalkanoic acids | Ectothiorhodospira shaposhnikovii
BGC0000866.1 |  | 0.49 | Other | polyhydroxyalkanoate | Burkholderia sp. DSM 9242
BGC0001589.1 |  | 0.48 | Saccharide | exopolysaccharides | Burkholderia cenocepacia J2315
BGC0001588.1 |  | 0.47 | Saccharide | exopolysaccharides | Burkholderia pseudomallei 1026b
BGC0000626.1 |  | 0.47 | RiPP | thuricin | Bacillus thuringiensis

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.
Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
c00035_NZ_JALC.. - Region 1 - proteusin
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 16,145 - 36,465 nt. (total: 20,321 nt) Show pHMM detection rules used
proteusin: (PoyD or TIGR03793)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
MIBiG comparison
KnownClusterBlast
Pfam domains
TIGRFAM domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | proteusin | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000795.1 |  | 0.14 | Saccharide | S-layer glycan | Aneurinibacillus thermoaerophilus
BGC0001133.1 |  | 0.05 | NRP | taxlllaid A | Xenorhabdus bovienii SS-2004

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000795.1 |  | 0.44 | Saccharide | S-layer glycan | Aneurinibacillus thermoaerophilus
BGC0001133.1 |  | 0.22 | NRP | taxlllaid A | Xenorhabdus bovienii SS-2004

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.
Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
c00056_NZ_JALC.. - Region 1 - NRPS
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 1 - 28,596 nt. (total: 28,596 nt) Show pHMM detection rules used
Region on contig edge.
NRPS: cds(Condensation and (AMP-binding or A-OX))

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
NRPS/PKS domains
MIBiG comparison
KnownClusterBlast
NRPS/PKS modules
Pfam domains
TIGRFAM domains
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
A glossary is available here.
Selected features only
Show module domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | NRPS | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000426.1 |  | 0.45 | NRP | sevadicin | Paenibacillus larvae
BGC0000389.1 |  | 0.41 | NRP | massetolide A | Pseudomonas fluorescens SS101
BGC0001050.1 |  | 0.37 | NRP, Polyketide | thalassospiramide A | Tistrella bauzanensis
BGC0001615.1 |  | 0.36 | NRP | hexose-palythine-serine, hexose-shinorine | Heteroscytonema crispum UCFS10
BGC0001833.1 |  | 0.35 | NRP | icosalide A, icosalide B | Burkholderia gladioli
BGC0000417.1 |  | 0.33 | NRP | rhodochelin | Rhodococcus jostii RHA1
BGC0000396.1 |  | 0.32 | NRP | nodularin | Nostoc sp. 73.1
BGC0001128.1 |  | 0.31 | NRP | luminmide | Photorhabdus laumondii subsp. laumondii TTO1
BGC0001825.1 |  | 0.31 | NRP | xenematide | Xenorhabdus nematophila AN6/1
BGC0001758.1 |  | 0.31 | NRP | rhizomide A, rhizomide B, rhizomide C | Paraburkholderia rhizoxinica HKI 454

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000426.1 |  | 0.75 | NRP | sevadicin | Paenibacillus larvae
BGC0000389.1 |  | 0.73 | NRP | massetolide A | Pseudomonas fluorescens SS101
BGC0001050.1 |  | 0.70 | NRP, Polyketide | thalassospiramide A | Tistrella bauzanensis
BGC0001615.1 |  | 0.68 | NRP | hexose-palythine-serine, hexose-shinorine | Heteroscytonema crispum UCFS10
BGC0001833.1 |  | 0.68 | NRP | icosalide A, icosalide B | Burkholderia gladioli
BGC0000417.1 |  | 0.66 | NRP | rhodochelin | Rhodococcus jostii RHA1
BGC0000396.1 |  | 0.65 | NRP | nodularin | Nostoc sp. 73.1
BGC0001128.1 |  | 0.65 | NRP | luminmide | Photorhabdus laumondii subsp. laumondii TTO1
BGC0001825.1 |  | 0.64 | NRP | xenematide | Xenorhabdus nematophila AN6/1
BGC0001758.1 |  | 0.64 | NRP | rhizomide A, rhizomide B, rhizomide C | Paraburkholderia rhizoxinica HKI 454

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.
Module view
Shows module structures for each candidate in NRPS- and PKS regions. Genes are shown in predicted order, and are only present when containing at least one complete module. A domain glossary is available here.
Legend
Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
NRPS/PKS products
NRPS/PKS monomers
Predicted core structure(s)
Shows estimated product structure and polymer for each candidate cluster in the region. To show the product, click on the expander or the candidate cluster feature drawn in the overview.
For candidate cluster 1, location 0 - 28596:
Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:
  (D-phe) + (pro - val - orn - leu)

Direct lookup in NORINE database: strict or relaxed
Link to NORINE database query form
NRPS/PKS monomer predictions
Shows the predicted monomers for each adynelation domain and acyltransferase within genes. Each gene prediction can be expanded to view detailed predictions of each domain. Each prediction can be expanded to view the predictions by tool (and, for some tools, further expanded for extra details).

ctg56_7: phe
  Search NORINE for peptide: strict or relaxed
  AMP-binding (35..427): phe
  NRPSPredictor2: phe
  SVM prediction details:
    Predicted physicochemical class:
      hydrophobic-aromatic
    Large clusters prediction:
      phe, trp, phg, tyr, bht
    Small clusters prediction:
      phe, trp
    Single AA prediction:
      phe
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DAWTvAAICK
    Nearest Stachelhaus code:
      phe
    Stachelhaus code match:
      90% (moderate)
ctg56_8: pro - val - orn - leu
  Search NORINE for peptide: strict or relaxed
  AMP-binding (473..869): pro
  NRPSPredictor2: pro
  SVM prediction details:
    Predicted physicochemical class:
      hydrophobic-aliphatic
    Large clusters prediction:
      pro, pip
    Small clusters prediction:
      pro
    Single AA prediction:
      pro
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DVQSIAHVVK
    Nearest Stachelhaus code:
      pro
    Stachelhaus code match:
      100% (strong)
  AMP-binding (1511..1904): val
  NRPSPredictor2: val
  SVM prediction details:
    Predicted physicochemical class:
      hydrophobic-aliphatic
    Large clusters prediction:
      gly, ala, val, leu, ile, abu, iva
    Small clusters prediction:
      val, leu, ile, abu, iva
    Single AA prediction:
      val
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DAFfIGGTFK
    Nearest Stachelhaus code:
      val
    Stachelhaus code match:
      90% (moderate)
  AMP-binding (2547..2949): orn
  NRPSPredictor2: orn
  SVM prediction details:
    Predicted physicochemical class:
      hydrophilic
    Large clusters prediction:
      orn, lys, arg
    Small clusters prediction:
      orn, horn
    Single AA prediction:
      orn
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DVGEIGSIDK
    Nearest Stachelhaus code:
      orn
    Stachelhaus code match:
      100% (strong)
  AMP-binding (3593..3987): leu
  NRPSPredictor2: leu
  SVM prediction details:
    NOTE: outside applicability domain
    Predicted physicochemical class:
      hydrophobic-aliphatic
    Large clusters prediction:
      gly, ala, val, leu, ile, abu, iva
    Small clusters prediction:
      val, leu, ile, abu, iva
    Single AA prediction:
      leu
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DGAYTGEVVK
    Nearest Stachelhaus code:
      leu
    Stachelhaus code match:
      100% (strong)

c00065_NZ_JALC.. - Region 1 - LAP,RiPP-like
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 1 - 19,791 nt. (total: 19,791 nt) Show pHMM detection rules used
Region on contig edge.
LAP: ((((goadsporin_like or PF00881 or TIGR03605) and (YcaO or TIGR03882 or TIGR03604)) or TIGR03603 or TIGR03602) and not cyanobactin_synth)
RiPP-like: (strepbact or Antimicrobial14 or Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or Lactococcin or Antimicrobial17 or Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or TIGR03975 or DUF692 or TIGR01193)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
MIBiG comparison
KnownClusterBlast
Pfam domains
TIGRFAM domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | LAP | RiPP-like | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | --- | ---
BGC0000607.1 |  |  | 0.52 | RiPP | micrococcin P1 | Macrococcus caseolyticus
BGC0000569.1 |  |  | 0.40 | RiPP | plantazolicin | Bacillus velezensis FZB42
BGC0001173.1 |  |  | 0.40 | RiPP | plantazolicin | Bacillus pumilus ATCC 7061
BGC0001146.1 |  |  | 0.39 | RiPP | cyclothiazomycin C | Streptomyces sp. NRRL WC-3908
BGC0000483.1 |  |  | 0.39 | RiPP | aeruginosamide B, aeruginosamide C | Microcystis aeruginosa PCC 9432
BGC0001145.1 |  |  | 0.33 | RiPP | cyclothiazomycin b1 | Streptomyces mobaraensis NBRC 13819 = DSM 40847
BGC0001849.1 |  |  | 0.33 | RiPP | thiovarsolin A, thiovarsolin B, thiovarsolin C, thiovarsolin D | Streptomyces varsoviensis
BGC0000628.1 |  |  | 0.32 | RiPP | lactocillin | Lactobacillus paragasseri JV-V03
BGC0000475.1 |  |  | 0.31 | RiPP | patellamide A, patellamide C | Prochloron didemni
BGC0000480.1 |  |  | 0.31 | RiPP | tenuecyclamide A, tenuecyclamide C | Nostoc spongiaeforme var. tenue str. Carmeli

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000607.1 |  | 0.59 | RiPP | micrococcin P1 | Macrococcus caseolyticus
BGC0000569.1 |  | 0.53 | RiPP | plantazolicin | Bacillus velezensis FZB42
BGC0001173.1 |  | 0.53 | RiPP | plantazolicin | Bacillus pumilus ATCC 7061
BGC0001146.1 |  | 0.52 | RiPP | cyclothiazomycin C | Streptomyces sp. NRRL WC-3908
BGC0000483.1 |  | 0.52 | RiPP | aeruginosamide B, aeruginosamide C | Microcystis aeruginosa PCC 9432
BGC0000628.1 |  | 0.50 | RiPP | lactocillin | Lactobacillus paragasseri JV-V03
BGC0001145.1 |  | 0.48 | RiPP | cyclothiazomycin b1 | Streptomyces mobaraensis NBRC 13819 = DSM 40847
BGC0001849.1 |  | 0.47 | RiPP | thiovarsolin A, thiovarsolin B, thiovarsolin C, thiovarsolin D | Streptomyces varsoviensis
BGC0001472.1 |  | 0.46 | RiPP | berninamycin A | Streptomyces bernensis
BGC0000475.1 |  | 0.46 | RiPP | patellamide A, patellamide C | Prochloron didemni

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.

No matches found.

Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
c00067_NZ_JALC.. - Region 1 - cyclic-lactone-autoinducer
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 1 - 16,490 nt. (total: 16,490 nt) Show pHMM detection rules used
Region on contig edge.
cyclic-lactone-autoinducer: (TIGR04223 or AgrB)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
MIBiG comparison
KnownClusterBlast
Pfam domains
TIGRFAM domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | cyclic-lactone-autoinducer | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001457.1 |  | 0.03 | NRP | jomthonic acid A, jomthonic acid B, jomthonic acid C | Streptomyces caniferus

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001457.1 |  | 0.16 | NRP | jomthonic acid A, jomthonic acid B, jomthonic acid C | Streptomyces caniferus

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.

No matches found.

Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names