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Overview
1.1
1.2
1.3
1.4

### Identified secondary metabolite regions using strictness 'relaxed'

NC_022369.1

Region | Type | From | To | Most similar known cluster | Similarity
--- | --- | --- | --- | --- | ---
Region 1 | betalactone | 583,745 | 616,311 |
Region 2 | RiPP-like | 836,007 | 848,241 |
Region 3 | T3PKS | 1,592,230 | 1,633,384 |
Region 4 | RaS-RiPP | 2,278,290 | 2,302,783 |

NC_022369.1 - Region 1 - betalactone
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 583,745 - 616,311 nt. (total: 32,567 nt) Show pHMM detection rules used
betalactone: (HMGL-like and AMP-binding)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
MIBiG comparison
KnownClusterBlast
Pfam domains
TIGRFAM domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | betalactone | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001521.1 |  | 0.17 | NRP | auriculamide | Herpetosiphon aurantiacus DSM 785
BGC0000554.1 |  | 0.16 | RiPP | SRO15-3108 | Streptomyces filamentosus NRRL 15998
BGC0000563.1 |  | 0.16 | RiPP | venezuelin | Streptomyces venezuelae ATCC 10712
BGC0000513.1 |  | 0.16 | RiPP | Ery-9, Ery-6, Ery-8, Ery-7, Ery-5, Ery-4, Ery-3 | Saccharopolyspora erythraea NRRL 2338
BGC0001579.1 |  | 0.16 | RiPP | duramycin | Streptomyces cinnamoneus
BGC0000501.1 |  | 0.16 | RiPP | catenulipeptin | Catenulispora acidiphila DSM 44928
BGC0001494.1 |  | 0.15 | RiPP | acinetodin | Acinetobacter gyllenbergii CIP 110306
BGC0000571.1 |  | 0.15 | RiPP | burhizin | Paraburkholderia rhizoxinica HKI 454
BGC0000558.1 |  | 0.15 | RiPP | sublancin 168 | Bacillus subtilis subsp. subtilis str. 168
BGC0000617.1 |  | 0.15 | RiPP | coagulin | Bacillus coagulans

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001521.1 |  | 0.48 | NRP | auriculamide | Herpetosiphon aurantiacus DSM 785
BGC0000554.1 |  | 0.47 | RiPP | SRO15-3108 | Streptomyces filamentosus NRRL 15998
BGC0000563.1 |  | 0.46 | RiPP | venezuelin | Streptomyces venezuelae ATCC 10712
BGC0000513.1 |  | 0.46 | RiPP | Ery-9, Ery-6, Ery-8, Ery-7, Ery-5, Ery-4, Ery-3 | Saccharopolyspora erythraea NRRL 2338
BGC0001579.1 |  | 0.46 | RiPP | duramycin | Streptomyces cinnamoneus
BGC0000501.1 |  | 0.46 | RiPP | catenulipeptin | Catenulispora acidiphila DSM 44928
BGC0001494.1 |  | 0.46 | RiPP | acinetodin | Acinetobacter gyllenbergii CIP 110306
BGC0000571.1 |  | 0.46 | RiPP | burhizin | Paraburkholderia rhizoxinica HKI 454
BGC0000558.1 |  | 0.46 | RiPP | sublancin 168 | Bacillus subtilis subsp. subtilis str. 168
BGC0000617.1 |  | 0.46 | RiPP | coagulin | Bacillus coagulans

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.

No matches found.

Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
NC_022369.1 - Region 2 - RiPP-like
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 836,007 - 848,241 nt. (total: 12,235 nt) Show pHMM detection rules used
RiPP-like: (strepbact or Antimicrobial14 or Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or Lactococcin or Antimicrobial17 or Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or TIGR03975 or DUF692 or TIGR01193)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
MIBiG comparison
KnownClusterBlast
Pfam domains
TIGRFAM domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | RiPP-like | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000617.1 |  | 0.19 | RiPP | coagulin | Bacillus coagulans
BGC0000584.1 |  | 0.15 | RiPP | colicin V | Escherichia coli
BGC0002009.1 |  | 0.14 | Polyketide | kanglemycin A, kanglemycin V1, kanglemycin V2 | Amycolatopsis vancoresmycina
BGC0000768.1 |  | 0.14 | Saccharide | gellan polysaccharide | Sphingomonas elodea ATCC 31461
BGC0000619.1 |  | 0.14 | RiPP | gassericin T | Lactobacillus gasseri
BGC0001602.1 |  | 0.14 | RiPP | gassericin-T | Lactobacillus gasseri
BGC0001388.1 |  | 0.14 | RiPP | gassericin E | Lactobacillus gasseri
BGC0000797.1 |  | 0.14 | Saccharide | sphingan polysaccharide | Sphingomonas sp. S88
BGC0001928.1 |  | 0.14 | Other | (2R,3S,4S)-5-fluoro-2,3,4-trihydroxypentanoic acid | Streptomyces sp. MA37
BGC0000759.1 |  | 0.14 | Saccharide | diutan polysaccharide | Sphingomonas sp. ATCC 53159

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000617.1 |  | 0.51 | RiPP | coagulin | Bacillus coagulans
BGC0000584.1 |  | 0.45 | RiPP | colicin V | Escherichia coli
BGC0002009.1 |  | 0.44 | Polyketide | kanglemycin A, kanglemycin V1, kanglemycin V2 | Amycolatopsis vancoresmycina
BGC0000768.1 |  | 0.43 | Saccharide | gellan polysaccharide | Sphingomonas elodea ATCC 31461
BGC0000619.1 |  | 0.43 | RiPP | gassericin T | Lactobacillus gasseri
BGC0001602.1 |  | 0.43 | RiPP | gassericin-T | Lactobacillus gasseri
BGC0001388.1 |  | 0.43 | RiPP | gassericin E | Lactobacillus gasseri
BGC0000797.1 |  | 0.43 | Saccharide | sphingan polysaccharide | Sphingomonas sp. S88
BGC0001928.1 |  | 0.43 | Other | (2R,3S,4S)-5-fluoro-2,3,4-trihydroxypentanoic acid | Streptomyces sp. MA37
BGC0000759.1 |  | 0.43 | Saccharide | diutan polysaccharide | Sphingomonas sp. ATCC 53159

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.

No matches found.

Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
NC_022369.1 - Region 3 - T3PKS
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 1,592,230 - 1,633,384 nt. (total: 41,155 nt) Show pHMM detection rules used
T3PKS: (Chal_sti_synt_C or Chal_sti_synt_N)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
MIBiG comparison
KnownClusterBlast
Pfam domains
TIGRFAM domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | T3PKS | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000286.1 |  | 0.23 | Polyketide | viguiepinol | Streptomyces sp. KO-3988
BGC0000764.1 |  | 0.19 | Saccharide | exopolysaccharide | Lactococcus lactis
BGC0000867.1 |  | 0.17 | Other | polyhydroxyalkanoic acids | Ectothiorhodospira shaposhnikovii
BGC0000866.1 |  | 0.17 | Other | polyhydroxyalkanoate | Burkholderia sp. DSM 9242
BGC0001080.1 |  | 0.14 | Other (Phenazine) | endophenazine A, endophenazine B | Streptomyces anulatus
BGC0001104.1 |  | 0.14 | NRP, Polyketide | myxovirescin A1 | Myxococcus xanthus DK 1622
BGC0001076.1 |  | 0.14 | Other (Nucleoside) | liposidomycin B, liposidomycin A, liposidomycin C, liposidomycin Z, liposidomycin H, liposidomycin G, liposidomycin L, liposidomycin M, liposidomycin K, liposidomycin N | Streptomyces sp. SN-1061M
BGC0000530.1 |  | 0.14 | RiPP | mutacin B-Ny266 | Streptococcus mutans N66
BGC0000934.1 |  | 0.14 | Other (Phenazine) | 5-acetyl-5,10-dihydrophenazine-1-carboxylic acid, 5-(2-hydroxyacetyl)-5,10-dihydrophenazine-1-carboxylic acid, endophenazine A1, endophenazine F, endophenazine G | Kitasatospora sp. HKI 714
BGC0000872.1 |  | 0.14 | Other | A-90289 A, A-90289 B | Streptomyces sp. SANK 60405

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000286.1 |  | 0.56 | Polyketide | viguiepinol | Streptomyces sp. KO-3988
BGC0000764.1 |  | 0.51 | Saccharide | exopolysaccharide | Lactococcus lactis
BGC0000867.1 |  | 0.49 | Other | polyhydroxyalkanoic acids | Ectothiorhodospira shaposhnikovii
BGC0000866.1 |  | 0.48 | Other | polyhydroxyalkanoate | Burkholderia sp. DSM 9242
BGC0001080.1 |  | 0.44 | Other (Phenazine) | endophenazine A, endophenazine B | Streptomyces anulatus
BGC0001104.1 |  | 0.44 | NRP, Polyketide | myxovirescin A1 | Myxococcus xanthus DK 1622
BGC0001076.1 |  | 0.44 | Other (Nucleoside) | liposidomycin B, liposidomycin A, liposidomycin C, liposidomycin Z, liposidomycin H, liposidomycin G, liposidomycin L, liposidomycin M, liposidomycin K, liposidomycin N | Streptomyces sp. SN-1061M
BGC0000530.1 |  | 0.43 | RiPP | mutacin B-Ny266 | Streptococcus mutans N66
BGC0000934.1 |  | 0.43 | Other (Phenazine) | 5-acetyl-5,10-dihydrophenazine-1-carboxylic acid, 5-(2-hydroxyacetyl)-5,10-dihydrophenazine-1-carboxylic acid, endophenazine A1, endophenazine F, endophenazine G | Kitasatospora sp. HKI 714
BGC0000872.1 |  | 0.43 | Other | A-90289 A, A-90289 B | Streptomyces sp. SANK 60405

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.

No matches found.

Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
NC_022369.1 - Region 4 - RaS-RiPP
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 2,278,290 - 2,302,783 nt. (total: 24,494 nt) Show pHMM detection rules used
RaS-RiPP: (PF04055 and TIGR01716)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
MIBiG comparison
KnownClusterBlast
Pfam domains
TIGRFAM domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | RaS-RiPP | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001209.1 |  | 0.23 | RiPP | streptide | Streptococcus thermophilus LMD-9
BGC0001929.1 |  | 0.21 | RiPP | WGK | Streptococcus ferus
BGC0000779.1 |  | 0.14 | Saccharide | lipopolysaccharide | Aeromonas piscicola
BGC0000938.1 |  | 0.14 | Other (Aminocoumarin) | fosfomycin | Streptomyces fradiae
BGC0000780.1 |  | 0.14 | Saccharide | O&K-antigen | Vibrio parahaemolyticus
BGC0000906.1 |  | 0.13 | Other | heme D1 | Heliophilum fasciatum
BGC0000905.1 |  | 0.13 | Other | heme D1 | Heliobacillus mobilis
BGC0000343.1 |  | 0.07 | NRP | enterobactin | Pseudomonas sp. J465
BGC0002016.1 |  | 0.07 | Polyketide | lugdunomycin | Streptomyces sp. QL37
BGC0000197.1 |  | 0.07 | Polyketide, Saccharide | aranciamycin | Streptomyces echinatus

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001209.1 |  | 0.56 | RiPP | streptide | Streptococcus thermophilus LMD-9
BGC0001929.1 |  | 0.54 | RiPP | WGK | Streptococcus ferus
BGC0000779.1 |  | 0.44 | Saccharide | lipopolysaccharide | Aeromonas piscicola
BGC0000938.1 |  | 0.44 | Other (Aminocoumarin) | fosfomycin | Streptomyces fradiae
BGC0000780.1 |  | 0.44 | Saccharide | O&K-antigen | Vibrio parahaemolyticus
BGC0000906.1 |  | 0.41 | Other | heme D1 | Heliophilum fasciatum
BGC0000905.1 |  | 0.41 | Other | heme D1 | Heliobacillus mobilis
BGC0000343.1 |  | 0.29 | NRP | enterobactin | Pseudomonas sp. J465
BGC0002016.1 |  | 0.28 | Polyketide | lugdunomycin | Streptomyces sp. QL37
BGC0000197.1 |  | 0.27 | Polyketide, Saccharide | aranciamycin | Streptomyces echinatus

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.

No matches found.

Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names