LOCUS       c00052_NZ_LWAG..       16073 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  NZ_LWAG01000044.1 Priestia endophytica strain 3617_2C
            3617_2C_contig_47, whole genome shotgun sequence.
ACCESSION   NZ_LWAG01000044
VERSION     NZ_LWAG01000044
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 6.1.1
            Run date     :: 2024-03-14 16:22:48
            Original ID  :: NZ_LWAG01000044.1
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 16073
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..16073
                     /aStool="rule-based-clusters"
                     /category="other"
                     /contig_edge="True"
                     /core_location="[1359:6073]"
                     /cutoff="10000"
                     /detection_rule="(HMGL-like and AMP-binding)"
                     /neighbourhood="10000"
                     /product="betalactone"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      1360..6073
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="(HMGL-like and AMP-binding)"
                     /neighbourhood="10000"
                     /product="betalactone"
                     /protocluster_number="1"
     cand_cluster    1..16073
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(HMGL-like and AMP-binding)"
                     /kind="single"
                     /product="betalactone"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..16073
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="betalactone"
                     /region_number="1"
                     /rules="(HMGL-like and AMP-binding)"
                     /tool="antismash"
     CDS             174..1313
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Acyl-CoA_dh_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Acyl-CoA_dh_M"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Acyl-CoA_dh_1"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1006:acyl-CoA dehydrogenase (Score: 440.6; E-value:
                     8.2e-134)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg52_1"
                     /sec_met_domain="Acyl-CoA_dh_N (E-value: 2.8e-38, bitscore:
                     122.3, seeds: 790, tool: rule-based-clusters)"
                     /sec_met_domain="Acyl-CoA_dh_M (E-value: 5.5e-29, bitscore:
                     91.5, seeds: 43, tool: rule-based-clusters)"
                     /sec_met_domain="Acyl-CoA_dh_1 (E-value: 2.3e-56, bitscore:
                     181.4, seeds: 49, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNFDLTKEQEMIRKLIRDFSEAEVAPGADERDRTGAFPYEIFSKL
                     AELGIMGLPFPEQYGGGDADTISFAIVVEELSRVCASSGITYSAHISLGGEPLNLFGTH
                     EQKEKYLTPICTGESFGAFGLTEPNAGSDAGGTQTTAVIDGDEWVINGSKCFITNASYA
                     KHLAVTAVTDRSKGINGISAFIVPTNAPGFTVINNYEKMGLQSSNTTELILENVRVTKD
                     NLLGTEGEGFKQFLATLDGGRIGIGAMAVGLAQGAYEKSLQYAKERKQFGKSISNFQAI
                     QFKLADMAMNIEIARNMVYKAAWLKNQGRVFKKEAAYAKLFASEICMRACDQAVQIHGG
                     YGYMKEYQVERFFRDAKLLEIGEGTSEVQRMVIAKQIGC"
     PFAM_domain     189..527
                     /aSDomain="Acyl-CoA_dh_N"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF02771.18"
                     /description="Acyl-CoA dehydrogenase, N-terminal domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg52_1_0001"
                     /evalue="2.70E-36"
                     /label="ctg52_1"
                     /locus_tag="ctg52_1"
                     /protein_end="118"
                     /protein_start="5"
                     /score="124.7"
                     /tool="antismash"
                     /translation="TKEQEMIRKLIRDFSEAEVAPGADERDRTGAFPYEIFSKLAELGI
                     MGLPFPEQYGGGDADTISFAIVVEELSRVCASSGITYSAHISLGGEPLNLFGTHEQKEK
                     YLTPICTGE"
     PFAM_domain     537..824
                     /aSDomain="Acyl-CoA_dh_M"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF02770.21"
                     /description="Acyl-CoA dehydrogenase, middle domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg52_1_0002"
                     /evalue="7.70E-27"
                     /label="ctg52_1"
                     /locus_tag="ctg52_1"
                     /protein_end="217"
                     /protein_start="121"
                     /score="93.4"
                     /tool="antismash"
                     /translation="AFGLTEPNAGSDAGGTQTTAVIDGDEWVINGSKCFITNASYAKHL
                     AVTAVTDRSKGINGISAFIVPTNAPGFTVINNYEKMGLQSSNTTELILENV"
     PFAM_domain     858..1304
                     /aSDomain="Acyl-CoA_dh_1"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00441.26"
                     /description="Acyl-CoA dehydrogenase, C-terminal domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg52_1_0003"
                     /evalue="1.20E-53"
                     /label="ctg52_1"
                     /locus_tag="ctg52_1"
                     /protein_end="377"
                     /protein_start="228"
                     /score="181.4"
                     /tool="antismash"
                     /translation="GEGFKQFLATLDGGRIGIGAMAVGLAQGAYEKSLQYAKERKQFGK
                     SISNFQAIQFKLADMAMNIEIARNMVYKAAWLKNQGRVFKKEAAYAKLFASEICMRACD
                     QAVQIHGGYGYMKEYQVERFFRDAKLLEIGEGTSEVQRMVIAKQI"
     CDS             1360..3315
                     /NRPS_PKS="Domain: AMP-binding (93-526). E-value: 4.3e-86.
                     Score: 280.9. Matches aSDomain:
                     nrpspksdomains_ctg52_2_AMP-binding.1"
                     /NRPS_PKS="type: NRPS-like protein"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     betalactone: AMP-binding"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1002:AMP-dependent synthetase and ligase (Score:
                     269.7; E-value: 6.5e-82)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg52_2"
                     /sec_met_domain="AMP-binding (E-value: 6.7e-96, bitscore:
                     312.5, seeds: 400, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDINGILQVVANSKLIFPNKEKVRSTSIGSIEAFQELLRQSQEDP
                     VAFWDSAARDLVWYEPWNETISGQLPDFRFFVDGISNPSVNLLDRHIVNGAGNRTALIW
                     EGENGDTKFYTYNMLLAEVNRFANVLRSFGVKKGDCVAVFLPNLAEAFIAVLACFRIGA
                     IYNTIFSGYSEKSLKDRLINFGPKVVVTADATERRGKAIRLKEKVDYVAPTIPSVEAVI
                     VVDRLGLEVQMKEGRDYWWHELTKTASIVCEPERIEANESGIVFYTSGTTGKPKGVVHS
                     GMAFVTQNYTYAKYHMDHHNDDVFWCTADIGWLTMHIWGITGALANGVTTVVYEGAVDY
                     PEKNRFYQIIEKYRVNKLFTAPTALRMLKSMGEKPLEQFDLSCLDVISLVGEPFDTETW
                     HWTYEVLGKKKVYINNTWGQTETAGSPIAGAAWLTPMKPGSSGTQFLGAVFDVVDEEGN
                     PVKTGQLGNLVIRKPFPMMCRTLWKEPERYYASYFSQVEGSYYASDLALVDEDGYIWVV
                     GRSDDAFNVAGHRLSTLEMESAVLECEGVFECAVIGIPDEIKGEVPLVFARLADGFEGT
                     KEIIERINNNIIQQIGKIASPKAIIMTNMLPKTVSGKIMRRLLKEIVATGKVAGDITGL
                     EDPSTVVEIQKIVADK"
     PFAM_domain     1462..1617
                     /aSDomain="ACAS_N"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF16177.7"
                     /description="Acetyl-coenzyme A synthetase N-terminus"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg52_2_0004"
                     /evalue="1.30E-10"
                     /label="ctg52_2"
                     /locus_tag="ctg52_2"
                     /protein_end="86"
                     /protein_start="34"
                     /score="41.1"
                     /tool="antismash"
                     /translation="QELLRQSQEDPVAFWDSAARDLVWYEPWNETISGQLPDFRFFVDG
                     ISNPSVN"
     PFAM_domain     1636..2937
                     /aSDomain="AMP-binding"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00501.30"
                     /description="AMP-binding enzyme"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg52_2_0005"
                     /evalue="2.90E-83"
                     /label="ctg52_2"
                     /locus_tag="ctg52_2"
                     /protein_end="526"
                     /protein_start="92"
                     /score="280.0"
                     /tool="antismash"
                     /translation="VNGAGNRTALIWEGENGDTKFYTYNMLLAEVNRFANVLRSFGVKK
                     GDCVAVFLPNLAEAFIAVLACFRIGAIYNTIFSGYSEKSLKDRLINFGPKVVVTADATE
                     RRGKAIRLKEKVDYVAPTIPSVEAVIVVDRLGLEVQMKEGRDYWWHELTKTASIVCEPE
                     RIEANESGIVFYTSGTTGKPKGVVHSGMAFVTQNYTYAKYHMDHHNDDVFWCTADIGWL
                     TMHIWGITGALANGVTTVVYEGAVDYPEKNRFYQIIEKYRVNKLFTAPTALRMLKSMGE
                     KPLEQFDLSCLDVISLVGEPFDTETWHWTYEVLGKKKVYINNTWGQTETAGSPIAGAAW
                     LTPMKPGSSGTQFLGAVFDVVDEEGNPVKTGQLGNLVIRKPFPMMCRTLWKEPERYYAS
                     YFSQVEGSYYASDLALVDEDGYIWVVGRSDDAFNV"
     aSDomain        1639..2937
                     /aSDomain="AMP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg52_2_AMP-binding.1"
                     /evalue="4.30E-86"
                     /label="ctg52_2_AMP-binding.1"
                     /locus_tag="ctg52_2"
                     /protein_end="526"
                     /protein_start="93"
                     /score="280.9"
                     /specificity="consensus: X"
                     /tool="antismash"
                     /translation="NGAGNRTALIWEGENGDTKFYTYNMLLAEVNRFANVLRSFGVKKG
                     DCVAVFLPNLAEAFIAVLACFRIGAIYNTIFSGYSEKSLKDRLINFGPKVVVTADATER
                     RGKAIRLKEKVDYVAPTIPSVEAVIVVDRLGLEVQMKEGRDYWWHELTKTASIVCEPER
                     IEANESGIVFYTSGTTGKPKGVVHSGMAFVTQNYTYAKYHMDHHNDDVFWCTADIGWLT
                     MHIWGITGALANGVTTVVYEGAVDYPEKNRFYQIIEKYRVNKLFTAPTALRMLKSMGEK
                     PLEQFDLSCLDVISLVGEPFDTETWHWTYEVLGKKKVYINNTWGQTETAGSPIAGAAWL
                     TPMKPGSSGTQFLGAVFDVVDEEGNPVKTGQLGNLVIRKPFPMMCRTLWKEPERYYASY
                     FSQVEGSYYASDLALVDEDGYIWVVGRSDDAFNV"
     CDS_motif       2152..2202
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ctg52_2_0001"
                     /evalue="8.00E-07"
                     /label="NRPS-A_a3"
                     /locus_tag="ctg52_2"
                     /protein_end="281"
                     /protein_start="264"
                     /score="21.6"
                     /tool="antismash"
                     /translation="VFYTSGTTGKPKGVVHS"
     PFAM_domain     2962..3198
                     /aSDomain="AMP-binding_C"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF13193.8"
                     /description="AMP-binding enzyme C-terminal domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg52_2_0006"
                     /evalue="1.70E-16"
                     /label="ctg52_2"
                     /locus_tag="ctg52_2"
                     /protein_end="613"
                     /protein_start="534"
                     /score="61.0"
                     /tool="antismash"
                     /translation="EMESAVLECEGVFECAVIGIPDEIKGEVPLVFARLADGFEGTKEI
                     IERINNNIIQQIGKIASPKAIIMTNMLPKTVSGK"
     PFAM_domain     3527..3856
                     /aSDomain="Biotin_carb_N"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00289.24"
                     /description="Biotin carboxylase, N-terminal domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg52_3_0007"
                     /evalue="3.10E-45"
                     /label="ctg52_3"
                     /locus_tag="ctg52_3"
                     /protein_end="110"
                     /protein_start="0"
                     /score="153.3"
                     /tool="antismash"
                     /translation="MFKKVLIANRSEIAVRVIRTCKALGITTVAVHSEADADAPHVKMA
                     DDAYLIGGSRVAESYLNIDKILEVARLTKAEAIHPGYGLLSENAEFARRCEEEGLIFIG
                     PSPKVI"
     CDS             3527..4888
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ATP-grasp"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1090:acetyl-CoA carboxylase biotin carboxylase (Score:
                     674.7; E-value: 2.7e-204)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg52_3"
                     /sec_met_domain="ATP-grasp (E-value: 9.9e-13, bitscore:
                     39.2, seeds: 20, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MFKKVLIANRSEIAVRVIRTCKALGITTVAVHSEADADAPHVKMA
                     DDAYLIGGSRVAESYLNIDKILEVARLTKAEAIHPGYGLLSENAEFARRCEEEGLIFIG
                     PSPKVISKMGSKIESRKAMEEAGVPVVPGITYPLADAEEAVEVADRIGYPVMLKASAGG
                     GGIGMQVVRSGDEIRKAFAGNQKRATDFFGDGAMYVEKFVENPRHIEIQILADGFGNTV
                     YLWERECSIQRRHQKVVEEAPSSFLSETTRSKMGEAAVKAAKSIGYKNVGTIEFLVDEE
                     QNFYFLEMNTRLQVEHPVTEEITGLDLVEKQLKIAGDEALDFSQEEVKREGHAIEVRIY
                     AEDPKTFFPSPGKITKLELPNGPGIRHELGVHDQSSVTPFYDPMIAKLIVKGSDRDDAI
                     NRLQDALADYHIEGIKTNIPMLEEVIAHPAFRSGDTTTDFVGKYLEIKKANNIK"
     PFAM_domain     3872..4492
                     /aSDomain="CPSase_L_D2"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF02786.19"
                     /description="Carbamoyl-phosphate synthase L chain, ATP
                     binding domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg52_3_0008"
                     /evalue="7.20E-77"
                     /label="ctg52_3"
                     /locus_tag="ctg52_3"
                     /protein_end="322"
                     /protein_start="115"
                     /score="257.7"
                     /tool="antismash"
                     /translation="KIESRKAMEEAGVPVVPGITYPLADAEEAVEVADRIGYPVMLKAS
                     AGGGGIGMQVVRSGDEIRKAFAGNQKRATDFFGDGAMYVEKFVENPRHIEIQILADGFG
                     NTVYLWERECSIQRRHQKVVEEAPSSFLSETTRSKMGEAAVKAAKSIGYKNVGTIEFLV
                     DEEQNFYFLEMNTRLQVEHPVTEEITGLDLVEKQLKIAGDEALD"
     PFAM_domain     4532..4846
                     /aSDomain="Biotin_carb_C"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF02785.21"
                     /description="Biotin carboxylase C-terminal domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg52_3_0009"
                     /evalue="1.40E-38"
                     /label="ctg52_3"
                     /locus_tag="ctg52_3"
                     /protein_end="440"
                     /protein_start="335"
                     /score="131.4"
                     /tool="antismash"
                     /translation="EVRIYAEDPKTFFPSPGKITKLELPNGPGIRHELGVHDQSSVTPF
                     YDPMIAKLIVKGSDRDDAINRLQDALADYHIEGIKTNIPMLEEVIAHPAFRSGDTTTDF
                     V"
     CDS             4897..5112
                     /locus_tag="ctg52_4"
                     /transl_table=11
                     /translation="MMSEIVASMAGNVWKVLVKVGDQVEEGQDVVILESMKMEIPIAAE
                     FDGTVKEVKVNEGDFVNEGDTIVKVE"
     PFAM_domain     4912..5103
                     /aSDomain="Biotin_lipoyl"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00364.24"
                     /description="Biotin-requiring enzyme"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg52_4_0010"
                     /evalue="3.80E-20"
                     /label="ctg52_4"
                     /locus_tag="ctg52_4"
                     /protein_end="69"
                     /protein_start="5"
                     /score="71.6"
                     /tool="antismash"
                     /translation="VASMAGNVWKVLVKVGDQVEEGQDVVILESMKMEIPIAAEFDGTV
                     KEVKVNEGDFVNEGDTIVK"
     CDS             5147..6073
                     /gene_functions="biosynthetic (rule-based-clusters)
                     betalactone: HMGL-like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1271:2-isopropylmalate synthase (Score: 239.7;
                     E-value: 1.1e-72)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg52_5"
                     /sec_met_domain="HMGL-like (E-value: 2.9e-55, bitscore:
                     178.8, seeds: 15, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKWPTNITIKEVGPRDGLQNEKGFISTEDKISLINQLSASGLKEI
                     EITSFVNSKWIPALSDAAAVATGITRVPGVTYTALVPNQQGLERAFEANIDEVAVFMSA
                     SETHNLKNINKSISNTFPILRDLVQKTLAAGKSSRGYVSTVFGCPYEGAVDIDMVIRVS
                     ETLFEMGIKELSLGDTIGVANPKQVQELLEVFLKKFPADKLAMHFHDTRGTALANVLVS
                     LEMGITTFDSSIGGLGGCPYAPGASGNVATDDLLYMLHGMGIHTGVDQEKLLSASQFIQ
                     KKIGRPLPSKSLQASISKYNSTCENTW"
     PFAM_domain     5165..5986
                     /aSDomain="HMGL-like"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00682.21"
                     /description="HMGL-like"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg52_5_0011"
                     /evalue="1.70E-52"
                     /label="ctg52_5"
                     /locus_tag="ctg52_5"
                     /protein_end="280"
                     /protein_start="6"
                     /score="178.6"
                     /tool="antismash"
                     /translation="ITIKEVGPRDGLQNEKGFISTEDKISLINQLSASGLKEIEITSFV
                     NSKWIPALSDAAAVATGITRVPGVTYTALVPNQQGLERAFEANIDEVAVFMSASETHNL
                     KNINKSISNTFPILRDLVQKTLAAGKSSRGYVSTVFGCPYEGAVDIDMVIRVSETLFEM
                     GIKELSLGDTIGVANPKQVQELLEVFLKKFPADKLAMHFHDTRGTALANVLVSLEMGIT
                     TFDSSIGGLGGCPYAPGASGNVATDDLLYMLHGMGIHTGVDQEKLLSASQFI"
     CDS             6087..6869
                     /NRPS_PKS="Domain: ECH (8-252). E-value: 4e-73. Score:
                     237.6. Matches aSDomain: nrpspksdomains_ctg52_6_ECH.1"
                     /NRPS_PKS="type: other"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1023:enoyl-CoA hydratase (Score: 271.9; E-value:
                     6.9e-83)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg52_6"
                     /transl_table=11
                     /translation="MDKTILVNRLENGIVMITLNRPEAANALSLQMLGELQEAVLLCKY
                     DRTIRCVVITGAGEKSFCAGADLKERADMEHVQVRKTLSLIRGNINDLEALPQPIIAAV
                     NGVAFGGGTELALACDIRIASETAKLGLTETSLGIIPGAGGTQRLPRLIGKGRAKELIF
                     TARRIDAAEALEIGLVEYTVPSNHLMEKALEIAGQIVRNGPIAITQAKFAIDKGYDVDI
                     NTGLAIEQSAYEVTIPSKDRLEGLQAFKEKRTPIYVGE"
     aSDomain        6111..6842
                     /aSDomain="ECH"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg52_6_ECH.1"
                     /evalue="4.00E-73"
                     /label="ctg52_6_ECH.1"
                     /locus_tag="ctg52_6"
                     /protein_end="252"
                     /protein_start="8"
                     /score="237.6"
                     /tool="antismash"
                     /translation="RLENGIVMITLNRPEAANALSLQMLGELQEAVLLCKYDRTIRCVV
                     ITGAGEKSFCAGADLKERADMEHVQVRKTLSLIRGNINDLEALPQPIIAAVNGVAFGGG
                     TELALACDIRIASETAKLGLTETSLGIIPGAGGTQRLPRLIGKGRAKELIFTARRIDAA
                     EALEIGLVEYTVPSNHLMEKALEIAGQIVRNGPIAITQAKFAIDKGYDVDINTGLAIEQ
                     SAYEVTIPSKDRLEGLQAFKEK"
     PFAM_domain     6117..6857
                     /aSDomain="ECH_1"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00378.22"
                     /description="Enoyl-CoA hydratase/isomerase"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg52_6_0012"
                     /evalue="1.90E-70"
                     /label="ctg52_6"
                     /locus_tag="ctg52_6"
                     /protein_end="257"
                     /protein_start="10"
                     /score="237.2"
                     /tool="antismash"
                     /translation="ENGIVMITLNRPEAANALSLQMLGELQEAVLLCKYDRTIRCVVIT
                     GAGEKSFCAGADLKERADMEHVQVRKTLSLIRGNINDLEALPQPIIAAVNGVAFGGGTE
                     LALACDIRIASETAKLGLTETSLGIIPGAGGTQRLPRLIGKGRAKELIFTARRIDAAEA
                     LEIGLVEYTVPSNHLMEKALEIAGQIVRNGPIAITQAKFAIDKGYDVDINTGLAIEQSA
                     YEVTIPSKDRLEGLQAFKEKRTPIY"
     CDS             6900..8438
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1059:acetyl-CoA carboxylase, carboxyl transferase,
                     (Score: 520.7; E-value: 7.8e-158)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg52_7"
                     /transl_table=11
                     /translation="MDMKPLQQILEERVEQIKKGGPSKYHQKNIEQGKLFVRDRLKQLF
                     DPGFELEDALFANYMAGELPADGVVTGMGKINGQVVCVMANDSTIKAGSWGSRTVEKII
                     RIQETAEKLRVPLIYLVDSAGARITDQVEMFPGRRGAGRIFYNQVKLSGKVPQICLLFG
                     PSAAGGAYIPAFCDIVIMVDKNASMYLGSPRMAEMVIGEKVTLEEMGGARMHCSVSGCG
                     DVLAKNEEEAITIARNYLSYFPANFSEKPPVHEAAAPKQMKSSLEELIPANQNSPFNMH
                     DLVNGIIDEGSFFEIKKRFATELITGLARMDGKPVGIIANQPRVKGGVLFHDTADKAAK
                     FINLCDAYHIPLLFLVDVPGFMIGTKVERAGIIRHGAKMISAMSEASVPKISVIVRKAY
                     GAGLYAMAGPAFEPDACLALPSASIAVMGPEAAVNAVYANKIASLPEEERVAFIAEKRE
                     EYKEDIDIYRLASEMVIDGVIPANSLRDELIKRFEVYSSKYLIFSERKHPVYPV"
     PFAM_domain     6984..8423
                     /aSDomain="Carboxyl_trans"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF01039.24"
                     /description="Carboxyl transferase domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg52_7_0013"
                     /evalue="6.00E-159"
                     /label="ctg52_7"
                     /locus_tag="ctg52_7"
                     /protein_end="508"
                     /protein_start="28"
                     /score="529.9"
                     /tool="antismash"
                     /translation="NIEQGKLFVRDRLKQLFDPGFELEDALFANYMAGELPADGVVTGM
                     GKINGQVVCVMANDSTIKAGSWGSRTVEKIIRIQETAEKLRVPLIYLVDSAGARITDQV
                     EMFPGRRGAGRIFYNQVKLSGKVPQICLLFGPSAAGGAYIPAFCDIVIMVDKNASMYLG
                     SPRMAEMVIGEKVTLEEMGGARMHCSVSGCGDVLAKNEEEAITIARNYLSYFPANFSEK
                     PPVHEAAAPKQMKSSLEELIPANQNSPFNMHDLVNGIIDEGSFFEIKKRFATELITGLA
                     RMDGKPVGIIANQPRVKGGVLFHDTADKAAKFINLCDAYHIPLLFLVDVPGFMIGTKVE
                     RAGIIRHGAKMISAMSEASVPKISVIVRKAYGAGLYAMAGPAFEPDACLALPSASIAVM
                     GPEAAVNAVYANKIASLPEEERVAFIAEKREEYKEDIDIYRLASEMVIDGVIPANSLRD
                     ELIKRFEVYSSKYLIFSERKHP"
     CDS             9202..9900
                     /locus_tag="ctg52_8"
                     /transl_table=11
                     /translation="MFIEFIATTLEDALLIEQSGADRIELVSALTEGGLTPSHSLIEAV
                     VNRVSIPVNVMVRPHSQSFCYSHDDFSIMKNDIKIIRSLGANGVVLGVLNENHEVNQHM
                     LEELLRECNGIEVTFHRAIDCTISPVQAAKTLAQYKEITTILTSGGNNEFSSRLQTIQK
                     MKTVCKHISILVGSGLNTSNILSVHSTVQTGYYHFGTAVRKNHSLIEGIHLEKAKEMVQ
                     ILKDEERKSV"
     PFAM_domain     9208..9792
                     /aSDomain="CutC"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF03932.16"
                     /description="CutC family"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg52_8_0014"
                     /evalue="5.20E-47"
                     /label="ctg52_8"
                     /locus_tag="ctg52_8"
                     /protein_end="197"
                     /protein_start="2"
                     /score="160.0"
                     /tool="antismash"
                     /translation="IEFIATTLEDALLIEQSGADRIELVSALTEGGLTPSHSLIEAVVN
                     RVSIPVNVMVRPHSQSFCYSHDDFSIMKNDIKIIRSLGANGVVLGVLNENHEVNQHMLE
                     ELLRECNGIEVTFHRAIDCTISPVQAAKTLAQYKEITTILTSGGNNEFSSRLQTIQKMK
                     TVCKHISILVGSGLNTSNILSVHSTVQTGYYH"
     CDS             complement(10226..10690)
                     /locus_tag="ctg52_9"
                     /transl_table=11
                     /translation="MGTIMVLFTLLGGIMLSAQSSVNGTFSRKAGTIEATLLTFITESI
                     FLAILILFFGEGNVLKILETPKWQLSAAFLGILYGLFVITAVPKIGVIATNIAGIVGQL
                     VIGILIDHFGWFNSLIFLFDLKRFFALLFMLVALYFIYTGNKRSSEETYA"
     PFAM_domain     complement(10274..10678)
                     /aSDomain="DMT_YdcZ"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF04657.15"
                     /description="Putative inner membrane exporter, YdcZ"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg52_9_0015"
                     /evalue="4.80E-25"
                     /label="ctg52_9"
                     /locus_tag="ctg52_9"
                     /protein_end="139"
                     /protein_start="4"
                     /score="88.5"
                     /tool="antismash"
                     /translation="MVLFTLLGGIMLSAQSSVNGTFSRKAGTIEATLLTFITESIFLAI
                     LILFFGEGNVLKILETPKWQLSAAFLGILYGLFVITAVPKIGVIATNIAGIVGQLVIGI
                     LIDHFGWFNSLIFLFDLKRFFALLFMLVALY"
     CDS             complement(10705..11133)
                     /locus_tag="ctg52_10"
                     /transl_table=11
                     /translation="MRYLSYLFALLAGAALSFEGGIYAELGKTIGKLETSFYNFFMGSI
                     IVGLIWLFAGKGKLSYTVEAPKWSLMGGFLGVVYLTSIVISVSFVGVGITMVAVIIGQL
                     VMSMVIEHYGWLGSKKSRINKEKIFAIVSMLIALISIN"
     PFAM_domain     complement(10717..11118)
                     /aSDomain="DMT_YdcZ"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF04657.15"
                     /description="Putative inner membrane exporter, YdcZ"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg52_10_0016"
                     /evalue="5.70E-33"
                     /label="ctg52_10"
                     /locus_tag="ctg52_10"
                     /protein_end="139"
                     /protein_start="5"
                     /score="114.2"
                     /tool="antismash"
                     /translation="YLFALLAGAALSFEGGIYAELGKTIGKLETSFYNFFMGSIIVGLI
                     WLFAGKGKLSYTVEAPKWSLMGGFLGVVYLTSIVISVSFVGVGITMVAVIIGQLVMSMV
                     IEHYGWLGSKKSRINKEKIFAIVSMLIALI"
     CDS             complement(11483..12403)
                     /locus_tag="ctg52_11"
                     /transl_table=11
                     /translation="MKEHKESAKSKTLRLLMPQWQGGNNPPYVLGAHLLNWLTPKTNGP
                     FEEVPIDLDSSLEIEQGIVAKSVLLNQARSAKSLIQKHSPDSIIVLGGDCGVELAPFAY
                     LNEKYDGDTALLWIDLHPDVSIPEEFPNHHAHVLANLLGVGDKEFVAEVPRPFKPEQVL
                     FVGLNDMMEALNSKPLQDIKVNIATPDDIKEDSSKVLQWLDSRKPSKVIVHFDLDVLDL
                     REFRSLLVANPATYEEMKDRVPASSSMETIIRVLQDVGKAHDVVGLGITEHFPWDAYNL
                     QNMLRRLPLLGDINKKDKAPYNWIF"
     PFAM_domain     complement(11738..12202)
                     /aSDomain="Arginase"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00491.23"
                     /description="Arginase family"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg52_11_0017"
                     /evalue="6.40E-15"
                     /label="ctg52_11"
                     /locus_tag="ctg52_11"
                     /protein_end="222"
                     /protein_start="67"
                     /score="55.5"
                     /tool="antismash"
                     /translation="VLLNQARSAKSLIQKHSPDSIIVLGGDCGVELAPFAYLNEKYDGD
                     TALLWIDLHPDVSIPEEFPNHHAHVLANLLGVGDKEFVAEVPRPFKPEQVLFVGLNDMM
                     EALNSKPLQDIKVNIATPDDIKEDSSKVLQWLDSRKPSKVIVHFDLDVLDL"
     CDS             complement(12485..13321)
                     /gene_functions="regulatory (smcogs)
                     SMCOG1171:transcriptional regulator, MerR family (Score:
                     63.1; E-value: 7.2e-19)"
                     /gene_kind="regulatory"
                     /locus_tag="ctg52_12"
                     /transl_table=11
                     /translation="MKQYFSIGETARLNNISIQTLRYYDKIGIFKPHYTDQGNGYRYYH
                     IKQFFYLDIIKYLKYIRIPLEEIRRIISGNPEHMQTFLEEQESVIEDEMDNLERARRLL
                     HRRKNQLKEQLEICNREKGIVYFRYMEEQTILKVATPQVNPHDQSDLYFRKLVDVLEER
                     GDMVDNYYGFIYDLKPYKDSRDIYCNNIYTTICKGEKVDIEGKNIQLDTIPSGEYVCIS
                     FDWSTKHYDSYYQELYHYIESNSIQTDGKVYQISLPTNYSSLREEQFLTELRVLKK"
     PFAM_domain     complement(13103..13309)
                     /aSDomain="MerR_1"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF13411.8"
                     /description="MerR HTH family regulatory protein"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg52_12_0018"
                     /evalue="6.20E-11"
                     /label="ctg52_12"
                     /locus_tag="ctg52_12"
                     /protein_end="73"
                     /protein_start="4"
                     /score="42.3"
                     /tool="antismash"
                     /translation="FSIGETARLNNISIQTLRYYDKIGIFKPHYTDQGNGYRYYHIKQF
                     FYLDIIKYLKYIRIPLEEIRRIIS"
     CDS             13682..14629
                     /locus_tag="ctg52_13"
                     /transl_table=11
                     /translation="MKNNNRICDILGIQYPIVQAAMSWITDAKMVAAVSNAGGMGVLGP
                     NAGAKFEGSKKISTEERLRNELRNIKSLTDKPFAVNIFSPDEGTDDTYTQTVLNISLEE
                     GIQTFLSVGFVNKKLFRQIKDHNATLIHRELTPTPEAAKMAESEGADIIIATGYDEGGW
                     IPQNQIGTFSIVPTIVDAVDIPVMATGGINDIRGVRAAFALGAEGVYVGTRFIVSEECP
                     ASDITKQDIIRSKAKDLVFVSSLQRSTPHKLARELESMYKNGMSPDEEMSLRPGMLEGK
                     LDEGIVSVNTAIDVITEVKSCEDIVKELMADFIK"
     PFAM_domain     13697..14614
                     /aSDomain="NMO"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF03060.17"
                     /description="Nitronate monooxygenase"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg52_13_0019"
                     /evalue="2.60E-74"
                     /label="ctg52_13"
                     /locus_tag="ctg52_13"
                     /protein_end="311"
                     /protein_start="5"
                     /score="250.7"
                     /tool="antismash"
                     /translation="RICDILGIQYPIVQAAMSWITDAKMVAAVSNAGGMGVLGPNAGAK
                     FEGSKKISTEERLRNELRNIKSLTDKPFAVNIFSPDEGTDDTYTQTVLNISLEEGIQTF
                     LSVGFVNKKLFRQIKDHNATLIHRELTPTPEAAKMAESEGADIIIATGYDEGGWIPQNQ
                     IGTFSIVPTIVDAVDIPVMATGGINDIRGVRAAFALGAEGVYVGTRFIVSEECPASDIT
                     KQDIIRSKAKDLVFVSSLQRSTPHKLARELESMYKNGMSPDEEMSLRPGMLEGKLDEGI
                     VSVNTAIDVITEVKSCEDIVKELMA"
     CDS             14898..15263
                     /locus_tag="ctg52_14"
                     /transl_table=11
                     /translation="MKELYKPLFEPCTFPCGIEIDNRIIMVPMATKSSFENGMVTLDEL
                     AYYKRRTKGLGMVITSATRIEKYGSQPGSISIATDKHIQSLSKLANTIKSNGTKAILQI
                     FHVGRMQTSIVEKRYFS"
     PFAM_domain     14919..15230
                     /aSDomain="Oxidored_FMN"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00724.22"
                     /description="NADH:flavin oxidoreductase / NADH oxidase
                     family"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg52_14_0020"
                     /evalue="1.50E-17"
                     /label="ctg52_14"
                     /locus_tag="ctg52_14"
                     /protein_end="111"
                     /protein_start="7"
                     /score="63.9"
                     /tool="antismash"
                     /translation="LFEPCTFPCGIEIDNRIIMVPMATKSSFENGMVTLDELAYYKRRT
                     KGLGMVITSATRIEKYGSQPGSISIATDKHIQSLSKLANTIKSNGTKAILQIFHVGRMQ
                     "
ORIGIN
        1 tatatttata acaaaatcat aaaaatagcg aaaggaggtc ggtacataga ggtttgttgt
       61 tattttgaca attattaaaa aagaaagccg attatgtata tttttgttgg aaggtaaaaa
      121 attttgtcaa caataatcaa attgttatga caataaatgg gggttgctga gaaatgaatt
      181 ttgatttaac gaaagaacaa gagatgatac gtaagttaat tcgggatttt tcggaagcag
      241 aagttgctcc tggagcagat gaacgagatc gaacgggagc attcccttat gaaatatttt
      301 caaaattagc agagttagga atcatgggtc ttccattccc agaacaatac ggtggcggtg
      361 atgctgacac tatcagcttt gccattgtcg ttgaagagtt aagtcgtgtt tgtgcatcct
      421 caggaatcac atattcagct catatttcat tagggggaga accgcttaat ttgtttggta
      481 cccatgagca aaaagagaaa tacttaacgc ccatttgtac aggagagtca tttggggcat
      541 ttggtttgac tgaaccaaat gccggctctg atgccggagg aacacaaaca accgcagtta
      601 ttgatgggga tgagtgggtc attaatggct caaaatgttt tattaccaat gcaagctatg
      661 ctaaacatct tgccgttacg gccgtaacag atcgctcaaa aggaattaat ggaattagcg
      721 catttatcgt tccaacgaac gcaccaggat ttactgttat taataattac gaaaaaatgg
      781 gtcttcaatc ttcaaataca acagaattaa tcttggaaaa tgtaagggtt accaaagata
      841 atctgctggg aacagaagga gagggtttca agcaattttt agctactttg gatggcggaa
      901 gaattggaat cggggcaatg gccgttggac ttgcacaggg cgcttatgaa aaatcacttc
      961 agtatgcaaa ggaaagaaaa cagtttggaa aaagtatatc aaacttccag gcaatccaat
     1021 ttaaattggc cgatatggca atgaatattg aaattgcccg aaatatggtt tacaaagcag
     1081 cctggttgaa gaatcaaggc cgagtattta aaaaagaggc agcatacgca aaattatttg
     1141 cttccgaaat atgtatgcgt gcatgtgatc aagctgttca aattcatggt ggttatggat
     1201 acatgaaaga atatcaagtt gagcggttct tccgtgatgc gaagcttttg gaaattgggg
     1261 aaggaacatc tgaagttcaa cgtatggtaa ttgcaaaaca aataggatgc tgaatacatt
     1321 tttgtaacgg ctatcaaaac atgataaagg agtaactcca tggatatcaa tgggatttta
     1381 caagtggttg caaacagtaa acttattttt cctaacaaag aaaaggtacg ctctacctcc
     1441 attggaagca tagaagcttt tcaagaactt cttcgacaat cccaagaaga tcctgtcgcc
     1501 ttttgggata gcgcagcccg tgatcttgta tggtatgaac cttggaatga aaccattagt
     1561 ggacaactcc ctgattttcg tttttttgtc gacggcatta gcaacccaag tgtcaattta
     1621 cttgaccggc atatagttaa tggggcgggc aaccggacag ctctcatttg ggagggtgaa
     1681 aacggggaca caaaatttta cacctataat atgcttcttg cggaagtaaa tcgatttgcg
     1741 aatgttcttc ggtcattcgg tgtaaaaaaa ggtgattgtg tagctgtttt tcttccaaat
     1801 ctcgcagaag catttattgc cgtgttagcg tgttttcgta ttggtgctat ttacaacact
     1861 attttctcag gttattccga aaaatcattg aaagaccgtc tcattaactt tgggccaaaa
     1921 gtagtggtaa ctgcagatgc aacagaacgt cgaggtaaag ccattcgatt aaaagaaaaa
     1981 gtcgattacg ttgcaccaac tatcccctct gttgaagcag tcattgttgt cgatcgttta
     2041 ggtttagagg ttcaaatgaa agaggggcgt gattactggt ggcacgagct tacaaaaacg
     2101 gcaagcatcg tttgtgaacc tgagagaata gaagcgaatg agagcgggat tgtgttctat
     2161 acaagtggta cgacaggaaa gcctaaaggt gtcgtccatt ctgggatggc ttttgtcact
     2221 caaaattaca catatgccaa gtatcatatg gatcaccaca atgatgatgt tttctggtgt
     2281 actgctgata tcggctggtt aacgatgcat atttggggta ttactggtgc tttagcgaat
     2341 ggggtaacaa ccgttgtcta tgaaggagca gttgattatc cagaaaagaa tcgcttttat
     2401 caaattattg aaaaataccg ggtgaataag ttatttaccg ccccaactgc attgagaatg
     2461 ttaaaaagta tgggagaaaa accattagag caatttgatt tatcttgtct tgatgtcatt
     2521 tcccttgtgg gagaaccttt tgatactgaa acatggcatt ggacatatga agttttagga
     2581 aagaaaaagg tatatatcaa taatacttgg gggcaaaccg aaacagcggg atctcctatc
     2641 gcaggagcag cctggctgac gccaatgaaa cctggttcct caggtactca atttttaggt
     2701 gcagtttttg atgttgttga tgaagaaggc aatccagtta aaactggtca gttaggaaac
     2761 ttagtgatta gaaaaccatt tcctatgatg tgccgtacac tttggaaaga accggagcga
     2821 tattacgcat cctattttag ccaagtagaa ggcagttatt atgccagcga tcttgcattg
     2881 gtagatgaag atggatatat atgggtagtt ggccgttctg atgacgcatt taatgtggcg
     2941 gggcatcggt taagtacgtt ggaaatggaa agtgctgtac ttgaatgcga aggtgttttt
     3001 gaatgcgctg tcattgggat tcctgatgaa ataaaagggg aagttccttt agtatttgcc
     3061 cgtctggctg atggttttga aggcaccaaa gagataatag aacggataaa taataatatt
     3121 atccaacaaa ttggtaagat tgccagtcca aaagcaataa ttatgactaa tatgttaccg
     3181 aaaacagtaa gtggaaaaat tatgcggcgt ttattaaaag aaattgttgc aacaggaaag
     3241 gtagctggtg acattacagg acttgaagac ccatcaactg ttgtagaaat acagaagatc
     3301 gttgctgata aatgatcagc tatataatgt tttattcggg ccagtcattt gttcggaaaa
     3361 tgatcggaaa atggctggtt tcatctaatc tttctctttg taatcactag attggcagtt
     3421 aaagatgaag gtgtagatag attcacatct ctccataacc taaaaattta accttcatga
     3481 gatacgcaaa gaacgcatta aataaaggat agaaagggtg gaaaggatgt tcaaaaaggt
     3541 tttgattgct aatcgtagtg aaattgctgt tcgggtaatc cggacatgca aggccctggg
     3601 gattactaca gttgctgtac actcagaagc tgatgcggat gctccccatg taaaaatggc
     3661 ggatgatgcc tatttaattg gaggttcgcg tgtagcagaa agttatttaa acatcgataa
     3721 aattttagaa gtcgcccgtt taacaaaagc agaggctatt caccctggat acggcctgct
     3781 ttccgaaaat gccgaatttg ctcggcgctg tgaggaggaa ggactgatat tcattggacc
     3841 ttctccaaag gttatctcca aaatgggcag caagattgaa tcacgaaaag cgatggaaga
     3901 agcaggagtc ccagttgttc ccgggattac ctaccctttg gcagatgcag aggaagcggt
     3961 agaagtggcg gaccgtattg gttatcctgt gatgctaaaa gcttccgctg gaggaggcgg
     4021 aattggaatg caggttgtcc gtagcgggga tgaaatccgc aaagcatttg cggggaacca
     4081 aaaacgggct actgatttct ttggcgatgg tgccatgtac gttgaaaaat ttgtggaaaa
     4141 ccctaggcat attgaaattc aaattctagc agacggattt ggcaataccg tttatctatg
     4201 ggaacgtgaa tgttcgatcc aacgtcgcca tcaaaaagtc gtcgaggaag ctccatcatc
     4261 ctttctttct gaaactaccc gcagcaaaat gggggaggcg gcagtaaaag cggcaaaatc
     4321 aattgggtat aaaaacgtag gaacaattga gtttttagta gatgaagagc aaaattttta
     4381 ttttcttgaa atgaataccc gtttgcaggt ggaacatcca gttacagaag aaattacagg
     4441 tttggactta gtggaaaaac aattgaaaat tgcaggggat gaagcgctgg atttttctca
     4501 ggaagaggta aaacgtgagg gtcatgcgat tgaagtcaga atttacgcag aggatccaaa
     4561 aacatttttt ccttctccag gaaaaatcac caaattagaa ttgccgaacg gacctggaat
     4621 tcgtcatgaa ttaggggttc atgatcaatc ttcagttact cctttttatg acccaatgat
     4681 tgcgaagctc attgtaaaag ggagcgatcg cgacgatgca ataaatcgtc tgcaggatgc
     4741 attagcagat tatcatatcg aaggaattaa aacaaatata ccaatgctgg aagaggtcat
     4801 tgctcacccg gcattccgtt caggtgatac gacaacggac tttgttggaa agtatttgga
     4861 aattaaaaaa gcaaataaca taaaatagga ggaatcatga tgagtgaaat cgtagcaagc
     4921 atggcaggaa atgtatggaa ggtacttgtt aaggttggag atcaagtcga agaaggccag
     4981 gatgtcgtga ttttagaatc aatgaaaatg gaaattccga ttgcagccga attcgatggg
     5041 actgttaaag aagtaaaagt gaacgagggc gactttgtga atgaaggaga cactattgta
     5101 aaagttgaat aaatcctcaa atcatcggag gaaaggagat gaatcaatga aatggcccac
     5161 gaatataacc attaaagagg ttggtccacg ggatggattg caaaacgaaa agggttttat
     5221 ttcaacagag gataaaattt ccttgattaa tcaattgtct gctagtggct taaaagagat
     5281 tgagattacc tcctttgtca attcgaaatg gattcctgca ctttcagatg ctgctgcagt
     5341 tgcaacaggc attacaagag tacctggtgt aacctatacg gctctcgttc caaaccaaca
     5401 agggttggag cgggcgtttg aagcgaacat tgatgaagta gctgtattta tgtcagccag
     5461 cgaaactcat aatctaaaaa atattaataa atcgattagt aatacattcc ctatcctgag
     5521 agatctggtc caaaaaaccc ttgcagcagg aaaatccagc agaggttatg tttctactgt
     5581 ttttggatgc ccatatgaag gggccgttga tatagatatg gttataagag tttcggaaac
     5641 cttatttgag atggggatta aggagctgtc actcggagat acgatcggtg ttgcgaatcc
     5701 aaagcaagtc caagaattgt tggaagtttt cttaaaaaaa ttcccagcag ataaattagc
     5761 gatgcacttt catgatacac ggggaacagc cttagctaac gttctagtat cgttagaaat
     5821 gggtattacc acttttgatt cttccattgg aggattagga ggatgccctt atgcgcctgg
     5881 agcatcaggt aatgtggcaa ctgatgattt actttatatg cttcacggga tgggaatcca
     5941 cactggggta gatcaggaaa agcttttatc tgcatcccaa tttattcaga agaagattgg
     6001 cagaccttta cctagtaaaa gtcttcaagc ttcaatctcc aaatacaaca gcacgtgtga
     6061 aaatacctgg tgaggaaggt gaaaatatgg ataaaacgat attagttaac aggctggaaa
     6121 acggaatcgt gatgattaca ttaaatcgcc ctgaagcggc caatgcttta tcccttcaaa
     6181 tgttagggga actccaagaa gcggttctat tatgtaaata tgaccggaca atccgttgtg
     6241 tagtgattac aggggctgga gaaaagtcct tttgcgcggg tgcagattta aaagaacgcg
     6301 cagatatgga acatgttcag gtacggaaga ccctttcctt gatccgtggg aatatcaatg
     6361 atttagaagc attaccgcag ccaattattg cggctgtgaa tggtgttgca tttggcgggg
     6421 gaacagaact tgcactggct tgtgatatcc gtattgcctc tgaaacagcg aagctgggtc
     6481 taacggaaac ctcactggga attattccgg gtgcaggcgg gacgcaacgt ttaccgagat
     6541 taataggaaa gggaagggct aaggaactta tttttacagc gagacgtatt gatgcagcag
     6601 aagccttaga gattggatta gtagagtata cggttccttc aaatcatttg atggaaaaag
     6661 ctttggaaat cgcagggcaa attgtccgga atggtccaat tgccatcaca caagcaaagt
     6721 tcgccattga taaaggctat gatgttgata ttaacaccgg tcttgccatt gagcaaagtg
     6781 cctatgaagt gacgattcca tcgaaagatc gtttagaagg attacaggcc tttaaggaaa
     6841 aaagaactcc catatatgtt ggagaataag aaaacgggat taatagagga ggaaagacaa
     6901 tggatatgaa acctctacaa caaatacttg aagaaagagt agaacagatt aaaaagggcg
     6961 gcccttctaa gtatcatcaa aaaaacatag aacaaggcaa actttttgtt cgagaccgtt
     7021 taaaacagtt attcgatccc ggctttgaac tagaggatgc gctatttgca aactacatgg
     7081 cgggggaact tcctgccgat ggcgttgtga cagggatggg gaagattaat ggccaggttg
     7141 tttgtgtgat ggctaatgat tcaaccatta aagctggttc ctggggatca cgaacggttg
     7201 agaaaatcat tagaattcaa gaaacagctg agaaacttcg tgtaccatta atttatttag
     7261 tagattcagc aggagcgcgg attacagatc aggtagaaat gtttcctggg cgccgcgggg
     7321 caggcagaat tttttacaat caagtgaaac tatctggaaa agtaccgcaa atttgtcttc
     7381 tgtttggtcc atctgccgca ggtggtgctt atatcccggc gttttgcgac atcgttatca
     7441 tggtagataa aaacgcatca atgtaccttg gctcgccacg aatggccgaa atggttatcg
     7501 gggaaaaagt tacattggaa gaaatgggcg gtgctcgcat gcattgttca gtatcagggt
     7561 gcggtgatgt actcgctaaa aacgaagagg aagccattac cattgcccgc aattatcttt
     7621 cttacttccc ggcaaatttt tcagaaaagc cgccggttca tgaggcagcg gcacctaaac
     7681 aaatgaagag ctcattggaa gagctgattc cggcaaatca aaactctcca tttaatatgc
     7741 atgaccttgt taatggaatt attgatgaag gttctttctt tgagattaag aaacgatttg
     7801 ctaccgagct tattacaggt cttgcccgca tggacggaaa acctgtcggt atcatagcca
     7861 atcagcctcg tgtaaagggc ggcgtgctgt tccatgatac tgctgacaaa gctgcgaaat
     7921 ttattaatct ttgtgatgca taccatattc cgttattgtt cctggttgat gtgcctggat
     7981 ttatgattgg cacaaaggta gaacgggcag gaatcattcg ccatggtgca aaaatgattt
     8041 ctgcaatgtc ggaggcaagt gtgccaaaga tctctgttat cgttcgaaag gcttatggtg
     8101 caggtctata tgccatggcc ggcccggcgt ttgaaccaga tgcttgtctg gctttacctt
     8161 ccgcttcgat tgccgtaatg ggaccagaag cagccgtcaa tgcagtgtat gccaacaaaa
     8221 ttgcttcatt acctgaagaa gagagggttg catttatcgc tgaaaagcgc gaggaatata
     8281 aagaagatat tgatatttac cggcttgctt cagaaatggt tattgatgga gttattccgg
     8341 caaactcact gcgcgacgag ttaattaaac gctttgaagt atattcttca aaatatttaa
     8401 tcttttctga gcgtaagcac ccagtctatc cagtataata tatggttcta tacgaggggg
     8461 ggtgtcctgt gaagaaaggt aaaatagtag aatcttttgc ggaagcgatt catgatgaat
     8521 tattttttta aaaaattttt attcgaaaca taaaaatgat ccaactcttt aacacccaaa
     8581 agagataaat atcaattgag cttctagatg cctggaaaag tataattaaa ggacaagaaa
     8641 aagctcaaat tcgttgttat tcaacgtgtt tgagctttta ttactttctt aaacatgttt
     8701 tatgttaact acttttgtat atcgtataca gctaaaaaag tattaaatag gccttattag
     8761 aaaagcttaa ataaaagagt gatttataga ctctataggt taccttttta tttttcagag
     8821 aataaagtac cttctactta gggatagggg gaagaaatat taaccataaa aaaataataa
     8881 ataaactaga taaaagccat gaaacccaaa gtttccattt atgaatgggt aataaagtat
     8941 taggtgagaa agtaaccctc tttctctaat attttacgct acatagaaac ccctgcacct
     9001 ataggagtag ggggattttt tgctttccct aacatgcttt atgtaaacta agtttgtata
     9061 tagtatgatt attgatacct cttttattag taaggagttg ttataacgaa tggagattag
     9121 tatggtaccc ttttattaaa ctctcttacc gtcaaaagta taaagaagag aagaagtcag
     9181 cataaaagga aggttgatac tatgttcata gaatttattg cgacaacgtt agaagatgct
     9241 ctattaattg aacaatcggg ggcagatcgg attgagttag tatccgcttt aacagaggga
     9301 ggattaacac caagtcactc cttaatcgaa gccgtagtta accgtgtaag cattccagtc
     9361 aatgtgatgg taaggccaca tagccaatca ttttgttact ctcatgacga cttttcgatc
     9421 atgaaaaatg atataaaaat aatccgttca ttaggtgcaa atggtgttgt actaggagtg
     9481 ttgaatgaga accatgaagt caaccaacac atgcttgaag agttattgag ggaatgcaat
     9541 ggtatagagg ttacatttca tcgagcaatt gattgtacaa tcagtcccgt tcaagcggct
     9601 aaaacattag cccaatacaa agaaataaca actattttaa cttctggtgg aaataatgaa
     9661 ttttccagtc gcttgcaaac cattcagaaa atgaaaacag tatgtaagca tatttcaatt
     9721 ttggttggaa gtgggttaaa tacaagcaat attctttctg ttcattcaac agtacaaacg
     9781 gggtattatc attttggtac ggctgtgaga aaaaaccata gtctgatcga aggaattcat
     9841 ctagaaaaag cgaaagaaat ggtgcaaata ttaaaagatg aagagagaaa atcagtataa
     9901 aaattattct atgtgatgca gggatgtcaa caagcataat ggatttatat tctgatacaa
     9961 gagatcatcc ttaaataagg gaactactta taattcgtgt tatgttaact aaaaaattat
    10021 attttataaa atataataga gcttcggttc acaaaggttt tatgtctttg atggcgatgt
    10081 tcttttttac agagatacgt tagcaatcta catcgttaca agatgtagat aattgaggga
    10141 gggatatgtc tatctcttct ctaatgaaaa gcgctgcaaa ccatacaagt aagggttgca
    10201 gcgctttttt catgatttaa ataggttagg cataagtttc ttcactggat cgtttattcc
    10261 ctgtataaat aaaataaagt gcaacaagca tgaatagtag tgcaaaaaaa cgttttaagt
    10321 caaagaggaa gatgagacta ttaaaccaac caaaatgatc aatcagaata ccaatgacaa
    10381 gctgaccaac aattcctgct atattggttg caataacgcc gatttttgga acagctgtaa
    10441 taacgaaaag tccatatagg ataccaagaa atgcagcact taattgccac ttcggtgttt
    10501 ctagtatttt aagtacattt ccttcgccaa agaaaagaat taaaatggct agaaatatgg
    10561 attccgttat aaaagttaaa agagtcgctt caatggttcc agcttttcga ctaaatgtac
    10621 cattgaccga tgattgagcg ctcaacatga taccgcccaa taaagtgaat agaaccatga
    10681 ttgttcccat gatgtttaat cctcctagtt aattgaaatt aatgcaataa gcattgaaac
    10741 aatcgcaaat attttttctt tattaattct cgatttctta ctaccaagcc aaccataatg
    10801 ttcaatcacc atactcatga ctaattgacc gattatgaca gcaaccatcg taataccaac
    10861 cccaacaaag gaaacactga tcacgatgga agttagataa acgacgccta aaaatcctcc
    10921 cattagtgac catttaggtg cttccacagt ataggaaagt ttccctttac ctgcgaatag
    10981 ccatattaat cccacaatga tggaccccat aaaaaagtta taaaaactcg tttccaattt
    11041 ccctatggtt tttcctaact cggcatatat acctccctca aagctaaggg ctgctcctgc
    11101 taataaggca aatagataag agagataacg cattactaga tcctcctatt ttcgtatatt
    11161 caaatatccg aaaaagtcga tgtatttatt tttaaagaca gaaactgaac aatctagatt
    11221 tctgtcttta aatgtttagt gaactgttga ataacttctt cctatcgcat ccaatagtcc
    11281 atttactata acgaacggat atttaagtaa accaaatttc tgcatcatgt aaatcattct
    11341 ctttggtaga ttcacgcctt gcttaggaaa aggctcctct gaatccttta acgatgataa
    11401 aaaatctagt ttatcttgat gatgatgtag atacatgtgg tagttctata accaacattt
    11461 tagattagtt ttatcttaat gtttagaaaa tccagttata aggagcttta tcctttttat
    11521 tgatatcccc tagtaacgga agtcgccgta acatattttg taagttataa gcatcccatg
    11581 gaaaatgttc tgtaatccct agccctacaa catcatgggc tttgcctaca tcttgaagga
    11641 cccgtataat ggtttccata ctagaacttg ctggaactcg atccttcatt tcctcataag
    11701 tagctggatt ggcgactaat agggaacgaa attctcttaa atcgagaacg tctaaatcaa
    11761 aatgaacgat aaccttagaa ggtttacgtg aatccagcca ctgaagtacc ttagaactgt
    11821 cttctttaat atcatctgga gtggcgatat tcacttttat atcttgtaac ggtttagagt
    11881 taagtgcttc catcatatcg ttcaatccta caaacaatac ttgttcgggt ttaaatggac
    11941 gaggtacctc tgcgacgaat tccttatccc cgacacccaa caaattagca agtacgtgag
    12001 catgatggtt tggaaactcc tcaggaatgg aaacatcagg gtgtaaatca atccataaca
    12061 aagcagtgtc tccatcatat ttttcgttta agtaggcaaa aggagcaagt tctacaccac
    12121 aatccccacc aagaacaata atactatcag gactgtgctt ttgaattaaa cttttagcag
    12181 acctcgcttg atttaataag acacttttag caacaatacc ctgctctatt tcaaggcttg
    12241 aatctaaatc gataggtact tcttcaaatg gaccgttcgt tttaggtgta agccagttta
    12301 acaaatgagc tccaagtacg tacggagggt tgtttccacc ttgccattgt ggcattagta
    12361 atcgaagagt cttacttttt gctgattctt tatgttcttt catttagcat cttcctttca
    12421 aaatatttat aagaactatg caacaaataa taaaccctat agtaactata gggtcaaggg
    12481 tgaactattt ttttagtact cttaattctg tgaggaactg ttcttctctt aatgagctat
    12541 agttggtagg aagagaaatt tgatatactt ttccatcggt ctggatgcta tttgattcaa
    12601 tataatggta aagttcttga taatatgaat cataatgttt ggtagaccaa tcaaatgaaa
    12661 tacatacata ttcacctgat gggatagtat ctaactgaat attttttcct tctatatcta
    12721 ccttttctcc tttacaaata gtcgtataaa tattattgca ataaatatcc cgagaatcct
    12781 tataaggctt taaatcataa atgaacccat aatagttatc gaccatgtct cctctttctt
    12841 ctaaaacatc caccaacttt cggaagtata aatctgattg atcatgagga ttaacttgag
    12901 gcgtcgctac ttttaaaatg gtttgttcct ccatatatcg aaagtaaact atcccttttt
    12961 ctctgttaca tatttctaac tgttccttaa gctgattctt tcttctatga agtaatcgcc
    13021 gagcacgttc gaggttatcc atttcatcct caataacact ttcttgctcc tcaagaaaag
    13081 tttgcatatg ttcagggtta cccgagatga tacgcctgat ttcttccaat gggattcgga
    13141 tatattttaa atacttgata atatctaaat aaaaaaactg tttaatatga taatatcgat
    13201 agccattacc ctgatctgtg taatgaggct tgaaaatgcc aatcttatca taatagcgca
    13261 aagtttgaat cgagatgtta ttgagacggg ctgtttcccc aatcgaaaaa tattgtttca
    13321 taaaccttat cctttcttct ccgttagctt ttaagaatct ttctcttact atacacgatt
    13381 ataaattaaa ttctccataa actaacttga gaagatagat aacctgctga aagtgagttt
    13441 taggcataca atgaggaatg cgttactttt gtaagaatta atataagaat ttttaagctt
    13501 aattatataa atcttaatgg tgtagagaat ttacctatct tataacaatt attaattgac
    13561 agtaaaaaat taacattaca aataaaaaaa tcaaaagaat tgaccctatt cctactatag
    13621 ggtttatgat ttgtgacgta gatttacaaa tagtcaaaga tagaaaagaa aggtgaatgt
    13681 tatgaaaaac aataacagaa tatgcgatat acttggaatt caatatccca ttgttcaagc
    13741 agccatgagc tggatcacgg atgcgaaaat ggtagcagcc gtgtccaatg ccggaggaat
    13801 gggagtttta ggtcctaatg ctggtgcgaa atttgaggga tctaaaaaga ttagtacgga
    13861 agaaagactt cgtaatgaat tacgcaacat taaatcacta acggataaac cttttgctgt
    13921 gaatattttc tctccagacg aggggacgga tgatacgtac acacaaaccg ttctaaatat
    13981 atctttagaa gaaggaattc aaacattcct aagtgttggc tttgtcaaca aaaaattatt
    14041 tagacaaatt aaagatcata atgccacgtt aattcaccgt gaattgactc ctacacctga
    14101 agctgcaaaa atggcagaat ctgaaggcgc agatatcatt attgcgacgg gctatgatga
    14161 aggcggatgg attcctcaga accaaattgg aaccttttcc atcgtgccaa cgatcgtaga
    14221 cgcagtagat attccggtaa tggctacagg tggaattaat gatattcgtg gtgtgagagc
    14281 tgcgtttgct cttggcgcgg aaggtgtcta tgtaggaaca cgttttattg tatcggaaga
    14341 atgtcctgct tcagacatta caaaacaaga tattattcgt tcaaaagcga aggacctggt
    14401 ttttgtgtcg tcacttcaac gttccacacc tcataaattg gctcgagagt tagagagtat
    14461 gtacaaaaat ggaatgtccc ctgacgagga aatgagtctt cgtccaggaa tgttagaggg
    14521 aaagctagat gaaggaatcg tttctgtaaa cacggctatt gatgttatta cggaagtaaa
    14581 gagttgtgaa gacatcgtca aagaattaat ggcagacttt attaagtaat tcaatactga
    14641 ttgttaaatc gtatataaag gaggattttc ttcagacatt aagtctagat tgttagttaa
    14701 cttatgtgtc gatagaggaa tacgcccctt tccaacagaa agggcttata ttcacctcga
    14761 aaatttttaa ttaagtctaa gattgtccaa aaagatgatt cgtcaatcat aacaagtgat
    14821 caagtcaagg gtcgattata attaatattc tttctttaat gcgtctttta atctcagtgt
    14881 aacaaggaga aatccgaatg aaagaacttt ataaaccatt atttgaaccc tgtacattcc
    14941 cctgtggaat agaaattgat aatagaataa ttatggttcc aatggcaaca aagtcatctt
    15001 ttgaaaatgg gatggttaca ttagatgagc ttgcttatta taaaaggaga actaagggac
    15061 ttggaatggt gataacttct gctactcgta ttgaaaaata cggaagtcag cctggttcaa
    15121 taagcattgc aacagacaaa catatccaaa gcttatctaa gttagccaat acaattaaga
    15181 gtaatggcac gaaagctatc ttgcagattt ttcatgtcgg aagaatgcag actagtattg
    15241 tagaaaaaag gtatttttca taataaagac actctttttt ataacatttt aaccgtttgt
    15301 gaaagttcac ctaaaggaaa ggaaaaagcg taaactcttt gttgctcatt gagtttgcgc
    15361 ttttttacta cctctaacat attttacgtt aactctgtct gtatatgata tataagcttt
    15421 tagattttaa tagatatatt taaggcctag agcaaaataa cacttgaaac aaatgtagaa
    15481 actttctcta ctttatttga acatttcttt cagtcttttt ataaaattcc ctttttagac
    15541 actataacta tgtattagca gtataaaaaa gtatactata caacaaaaat gtgcgtactt
    15601 gttgagctga tttatagggt ttattataaa attgtaaacg gaggttatat aaaattgtat
    15661 gttaactagt tgttagttgt atgccataga gagaacacct tcctttaaag ggttctctac
    15721 tgaatacttt tacagaaggg ttgattttat atgaataaca cagataaaaa acaagaaatt
    15781 ttagacgcat ttacatttcg tcatgccaca aaggaatttg atccaaccaa gaaaatttcc
    15841 gatgaagatt ttcaatttat tttagaaaca ggtcgcttat ctccaagctc agtagggtat
    15901 gaaccatgga agtttttagt tgttgaaaat gaggaattaa agaataaatt aaaagctgtt
    15961 tcttggggag cacaagggca aatccctaca gcgagtcatt ttgttattat ccttgctcgt
    16021 acagatgcaa ggtacgattc tgagtacgta ttagacctcc aaaagaatgt gaa
//
