Select genomic region:
Overview
11.1
11.2
18.1
21.1
25.1
29.1
33.1
35.1
52.1
53.1
57.1
57.2
77.1
81.1

### Identified secondary metabolite regions using strictness 'relaxed'

NZ_LWAG01000001 (original name was: NZ_LWAG01000001.1)

Region | Type | From | To | Most similar known cluster | Similarity
--- | --- | --- | --- | --- | ---
Region 11.1 | lassopeptide | 2,315 | 26,168 | paeninodin | RiPP | 80%
Region 11.2 | NRPS | 49,083 | 96,210 | bacillibactin | NRP | 46%

NZ_LWAG01000008 (original name was: NZ_LWAG01000008.1)

Region | Type | From | To | Most similar known cluster | Similarity
--- | --- | --- | --- | --- | ---
Region 18.1 | LAP,RiPP-like | 46,042 | 69,587 |

NZ_LWAG01000011 (original name was: NZ_LWAG01000011.1)

Region | Type | From | To | Most similar known cluster | Similarity
--- | --- | --- | --- | --- | ---
Region 21.1 | T3PKS | 1 | 35,020 |

NZ_LWAG01000015 (original name was: NZ_LWAG01000015.1)

Region | Type | From | To | Most similar known cluster | Similarity
--- | --- | --- | --- | --- | ---
Region 25.1 | lanthipeptide-class-ii | 2,886 | 31,369 |

NZ_LWAG01000019 (original name was: NZ_LWAG01000019.1)

Region | Type | From | To | Most similar known cluster | Similarity
--- | --- | --- | --- | --- | ---
Region 29.1 | terpene | 29,098 | 50,954 |

NZ_LWAG01000024 (original name was: NZ_LWAG01000024.1)

Region | Type | From | To | Most similar known cluster | Similarity
--- | --- | --- | --- | --- | ---
Region 33.1 | terpene | 148,311 | 169,129 |

NZ_LWAG01000026 (original name was: NZ_LWAG01000026.1)

Region | Type | From | To | Most similar known cluster | Similarity
--- | --- | --- | --- | --- | ---
Region 35.1 | NRPS,T1PKS | 19,233 | 89,094 | paenilamicin | NRP + Polyketide | 28%

NZ_LWAG01000044 (original name was: NZ_LWAG01000044.1)

Region | Type | From | To | Most similar known cluster | Similarity
--- | --- | --- | --- | --- | ---
Region 52.1 | betalactone | 1 | 16,073 | fengycin | NRP | 40%

NZ_LWAG01000045 (original name was: NZ_LWAG01000045.1)

Region | Type | From | To | Most similar known cluster | Similarity
--- | --- | --- | --- | --- | ---
Region 53.1 | NRPS | 4,537 | 70,450 |

NZ_LWAG01000049 (original name was: NZ_LWAG01000049.1)

Region | Type | From | To | Most similar known cluster | Similarity
--- | --- | --- | --- | --- | ---
Region 57.1 | siderophore | 1 | 13,391 |
Region 57.2 | RRE-containing | 15,011 | 32,514 |

NZ_LWAG01000075 (original name was: NZ_LWAG01000075.1)

Region | Type | From | To | Most similar known cluster | Similarity
--- | --- | --- | --- | --- | ---
Region 77.1 | NRPS | 3,189 | 34,988 |

NZ_LWAG01000079 (original name was: NZ_LWAG01000079.1)

Region | Type | From | To | Most similar known cluster | Similarity
--- | --- | --- | --- | --- | ---
Region 81.1 | lanthipeptide-class-ii | 1 | 13,936 |

Region | Type | From | To | Most similar known cluster | Similarity
--- | --- | --- | --- | --- | ---
Region 11.1 | lassopeptide | 2,315 | 26,168 | paeninodin | RiPP | 80%
Region 11.2 | NRPS | 49,083 | 96,210 | bacillibactin | NRP | 46%
Region 18.1 | LAP,RiPP-like | 46,042 | 69,587 |
Region 21.1 | T3PKS | 1 | 35,020 |
Region 25.1 | lanthipeptide-class-ii | 2,886 | 31,369 |
Region 29.1 | terpene | 29,098 | 50,954 |
Region 33.1 | terpene | 148,311 | 169,129 |
Region 35.1 | NRPS,T1PKS | 19,233 | 89,094 | paenilamicin | NRP + Polyketide | 28%
Region 52.1 | betalactone | 1 | 16,073 | fengycin | NRP | 40%
Region 53.1 | NRPS | 4,537 | 70,450 |
Region 57.1 | siderophore | 1 | 13,391 |
Region 57.2 | RRE-containing | 15,011 | 32,514 |
Region 77.1 | NRPS | 3,189 | 34,988 |
Region 81.1 | lanthipeptide-class-ii | 1 | 13,936 |

No secondary metabolite regions were found in these records:
  NZ_LWAG01000056 (original name was: NZ_LWAG01000056.1)
  NZ_LWAG01000065 (original name was: NZ_LWAG01000065.1)
  NZ_LWAG01000051 (original name was: NZ_LWAG01000051.1)
  NZ_LWAG01000098 (original name was: NZ_LWAG01000098.1)
  NZ_LWAG01000063 (original name was: NZ_LWAG01000063.1)
  NZ_LWAG01000039 (original name was: NZ_LWAG01000039.1)
  NZ_LWAG01000071 (original name was: NZ_LWAG01000071.1)
  NZ_LWAG01000090 (original name was: NZ_LWAG01000090.1)
  NZ_LWAG01000023 (original name was: NZ_LWAG01000023.1)
  NZ_LWAG01000068 (original name was: NZ_LWAG01000068.1)
  NZ_LWAG01000002 (original name was: NZ_LWAG01000002.1)
  NZ_LWAG01000003 (original name was: NZ_LWAG01000003.1)
  NZ_LWAG01000004 (original name was: NZ_LWAG01000004.1)
  NZ_LWAG01000005 (original name was: NZ_LWAG01000005.1)
  NZ_LWAG01000006 (original name was: NZ_LWAG01000006.1)
  NZ_LWAG01000007 (original name was: NZ_LWAG01000007.1)
  NZ_LWAG01000009 (original name was: NZ_LWAG01000009.1)
  NZ_LWAG01000010 (original name was: NZ_LWAG01000010.1)
  NZ_LWAG01000012 (original name was: NZ_LWAG01000012.1)
  NZ_LWAG01000013 (original name was: NZ_LWAG01000013.1)
  NZ_LWAG01000014 (original name was: NZ_LWAG01000014.1)
  NZ_LWAG01000016 (original name was: NZ_LWAG01000016.1)
  NZ_LWAG01000017 (original name was: NZ_LWAG01000017.1)
  NZ_LWAG01000018 (original name was: NZ_LWAG01000018.1)
  NZ_LWAG01000020 (original name was: NZ_LWAG01000020.1)
  NZ_LWAG01000021 (original name was: NZ_LWAG01000021.1)
  NZ_LWAG01000022 (original name was: NZ_LWAG01000022.1)
  NZ_LWAG01000025 (original name was: NZ_LWAG01000025.1)
  NZ_LWAG01000027 (original name was: NZ_LWAG01000027.1)
  NZ_LWAG01000028 (original name was: NZ_LWAG01000028.1)
  NZ_LWAG01000029 (original name was: NZ_LWAG01000029.1)
  NZ_LWAG01000030 (original name was: NZ_LWAG01000030.1)
  NZ_LWAG01000031 (original name was: NZ_LWAG01000031.1)
  NZ_LWAG01000032 (original name was: NZ_LWAG01000032.1)
  NZ_LWAG01000033 (original name was: NZ_LWAG01000033.1)
  NZ_LWAG01000034 (original name was: NZ_LWAG01000034.1)
  NZ_LWAG01000035 (original name was: NZ_LWAG01000035.1)
  NZ_LWAG01000036 (original name was: NZ_LWAG01000036.1)
  NZ_LWAG01000037 (original name was: NZ_LWAG01000037.1)
  NZ_LWAG01000038 (original name was: NZ_LWAG01000038.1)
  NZ_LWAG01000040 (original name was: NZ_LWAG01000040.1)
  NZ_LWAG01000041 (original name was: NZ_LWAG01000041.1)
  NZ_LWAG01000042 (original name was: NZ_LWAG01000042.1)
  NZ_LWAG01000043 (original name was: NZ_LWAG01000043.1)
  NZ_LWAG01000046 (original name was: NZ_LWAG01000046.1)
  NZ_LWAG01000047 (original name was: NZ_LWAG01000047.1)
  NZ_LWAG01000048 (original name was: NZ_LWAG01000048.1)
  NZ_LWAG01000050 (original name was: NZ_LWAG01000050.1)
  NZ_LWAG01000052 (original name was: NZ_LWAG01000052.1)
  NZ_LWAG01000053 (original name was: NZ_LWAG01000053.1)
  NZ_LWAG01000054 (original name was: NZ_LWAG01000054.1)
  NZ_LWAG01000055 (original name was: NZ_LWAG01000055.1)
  NZ_LWAG01000057 (original name was: NZ_LWAG01000057.1)
  NZ_LWAG01000058 (original name was: NZ_LWAG01000058.1)
  NZ_LWAG01000059 (original name was: NZ_LWAG01000059.1)
  NZ_LWAG01000060 (original name was: NZ_LWAG01000060.1)
  NZ_LWAG01000061 (original name was: NZ_LWAG01000061.1)
  NZ_LWAG01000062 (original name was: NZ_LWAG01000062.1)
  NZ_LWAG01000064 (original name was: NZ_LWAG01000064.1)
  NZ_LWAG01000066 (original name was: NZ_LWAG01000066.1)
  NZ_LWAG01000067 (original name was: NZ_LWAG01000067.1)
  NZ_LWAG01000069 (original name was: NZ_LWAG01000069.1)
  NZ_LWAG01000070 (original name was: NZ_LWAG01000070.1)
  NZ_LWAG01000072 (original name was: NZ_LWAG01000072.1)
  NZ_LWAG01000073 (original name was: NZ_LWAG01000073.1)
  NZ_LWAG01000074 (original name was: NZ_LWAG01000074.1)
  NZ_LWAG01000076 (original name was: NZ_LWAG01000076.1)
  NZ_LWAG01000077 (original name was: NZ_LWAG01000077.1)
  NZ_LWAG01000078 (original name was: NZ_LWAG01000078.1)
  NZ_LWAG01000080 (original name was: NZ_LWAG01000080.1)
  NZ_LWAG01000081 (original name was: NZ_LWAG01000081.1)
  NZ_LWAG01000082 (original name was: NZ_LWAG01000082.1)
  NZ_LWAG01000083 (original name was: NZ_LWAG01000083.1)
  NZ_LWAG01000084 (original name was: NZ_LWAG01000084.1)
  NZ_LWAG01000085 (original name was: NZ_LWAG01000085.1)
  NZ_LWAG01000086 (original name was: NZ_LWAG01000086.1)
  NZ_LWAG01000087 (original name was: NZ_LWAG01000087.1)
  NZ_LWAG01000088 (original name was: NZ_LWAG01000088.1)
  NZ_LWAG01000089 (original name was: NZ_LWAG01000089.1)
  NZ_LWAG01000091 (original name was: NZ_LWAG01000091.1)
  NZ_LWAG01000092 (original name was: NZ_LWAG01000092.1)
  NZ_LWAG01000093 (original name was: NZ_LWAG01000093.1)
  NZ_LWAG01000094 (original name was: NZ_LWAG01000094.1)
  NZ_LWAG01000095 (original name was: NZ_LWAG01000095.1)
  NZ_LWAG01000096 (original name was: NZ_LWAG01000096.1)
  NZ_LWAG01000097 (original name was: NZ_LWAG01000097.1)
  NZ_LWAG01000099 (original name was: NZ_LWAG01000099.1)

Compact view
c00011_NZ_LWAG.. - Region 1 - lassopeptide
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 2,315 - 26,168 nt. (total: 23,854 nt) Show pHMM detection rules used
lassopeptide: (PF13471 and Asn_synthase or micJ25 or mcjC)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
MIBiG comparison
KnownClusterBlast
Lasso peptides
Pfam domains
TIGRFAM domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | lassopeptide | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001356.1 |  | 0.38 | RiPP | paeninodin | Paenibacillus dendritiformis C454
BGC0001634.1 |  | 0.37 | RiPP | keywimysin | Streptomyces sp. NRRL F-5702
BGC0000575.1 |  | 0.35 | RiPP | lariatin | Rhodococcus jostii
BGC0001549.1 |  | 0.35 | RiPP | citrulassin B | Streptomyces aurantiacus JA 4570
BGC0001176.1 |  | 0.34 | RiPP | streptomonomicin | Streptomonospora alba
BGC0001550.1 |  | 0.34 | RiPP | citrulassin D | Streptomyces katrae
BGC0001496.1 |  | 0.32 | RiPP | actinokineosin | Actinokineospora spheciospongiae
BGC0001552.1 |  | 0.31 | RiPP | citrulassin F | Streptomyces avermitilis MA-4680 = NBRC 14893
BGC0000571.1 |  | 0.29 | RiPP | burhizin | Paraburkholderia rhizoxinica HKI 454
BGC0001889.1 |  | 0.28 | RiPP | fusilassin | Thermobifida fusca YX

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001356.1 |  | 0.70 | RiPP | paeninodin | Paenibacillus dendritiformis C454
BGC0001634.1 |  | 0.69 | RiPP | keywimysin | Streptomyces sp. NRRL F-5702
BGC0000575.1 |  | 0.68 | RiPP | lariatin | Rhodococcus jostii
BGC0001549.1 |  | 0.68 | RiPP | citrulassin B | Streptomyces aurantiacus JA 4570
BGC0001176.1 |  | 0.67 | RiPP | streptomonomicin | Streptomonospora alba
BGC0001550.1 |  | 0.67 | RiPP | citrulassin D | Streptomyces katrae
BGC0001496.1 |  | 0.65 | RiPP | actinokineosin | Actinokineospora spheciospongiae
BGC0001552.1 |  | 0.64 | RiPP | citrulassin F | Streptomyces avermitilis MA-4680 = NBRC 14893
BGC0000571.1 |  | 0.62 | RiPP | burhizin | Paraburkholderia rhizoxinica HKI 454
BGC0001889.1 |  | 0.62 | RiPP | fusilassin | Thermobifida fusca YX

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.
Lasso peptide predictions
Lists the possible core peptides for each biosynthetic enzyme, including the predicted class. Each core peptide shows the leader and core peptide sequences, separated by a dash.
Lassopeptides - No core peptides found.
Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
Lasso peptides
Core peptide predictions
Lists the possible core peptides in the region. Each core peptide lists the number of disulfide bridges, possible molecular weights, and the scores for cleavage site prediction and RODEO.
No core peptides found.
c00011_NZ_LWAG.. - Region 2 - NRPS
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 49,083 - 96,210 nt. (total: 47,128 nt) Show pHMM detection rules used
NRPS: cds(Condensation and (AMP-binding or A-OX))

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
NRPS/PKS domains
MIBiG comparison
KnownClusterBlast
NRPS/PKS modules
Pfam domains
TIGRFAM domains
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
A glossary is available here.
Selected features only
Show module domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | NRPS | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001185.1 |  | 0.54 | NRP | bacillibactin | Bacillus velezensis FZB42
BGC0000401.1 |  | 0.43 | NRP | paenibactin | Paenibacillus elgii B69
BGC0001615.1 |  | 0.33 | NRP | hexose-palythine-serine, hexose-shinorine | Heteroscytonema crispum UCFS10
BGC0000309.1 |  | 0.30 | NRP | bacillibactin | Bacillus subtilis subsp. subtilis str. 168
BGC0001149.1 |  | 0.29 | NRP, Saccharide | brabantamide A | Pseudomonas sp. SHC52
BGC0000410.1 |  | 0.28 | NRP | pseudomonine | Pseudomonas fluorescens
BGC0001833.1 |  | 0.27 | NRP | icosalide A, icosalide B | Burkholderia gladioli
BGC0001132.1 |  | 0.27 | NRP | xenotetrapeptide | Xenorhabdus nematophila ATCC 19061
BGC0000417.1 |  | 0.27 | NRP | rhodochelin | Rhodococcus jostii RHA1
BGC0001825.1 |  | 0.27 | NRP | xenematide | Xenorhabdus nematophila AN6/1

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001185.1 |  | 0.81 | NRP | bacillibactin | Bacillus velezensis FZB42
BGC0000401.1 |  | 0.74 | NRP | paenibactin | Paenibacillus elgii B69
BGC0001615.1 |  | 0.67 | NRP | hexose-palythine-serine, hexose-shinorine | Heteroscytonema crispum UCFS10
BGC0000309.1 |  | 0.63 | NRP | bacillibactin | Bacillus subtilis subsp. subtilis str. 168
BGC0001149.1 |  | 0.63 | NRP, Saccharide | brabantamide A | Pseudomonas sp. SHC52
BGC0000410.1 |  | 0.62 | NRP | pseudomonine | Pseudomonas fluorescens
BGC0001833.1 |  | 0.61 | NRP | icosalide A, icosalide B | Burkholderia gladioli
BGC0001132.1 |  | 0.61 | NRP | xenotetrapeptide | Xenorhabdus nematophila ATCC 19061
BGC0000417.1 |  | 0.61 | NRP | rhodochelin | Rhodococcus jostii RHA1
BGC0001825.1 |  | 0.61 | NRP | xenematide | Xenorhabdus nematophila AN6/1

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.
Module view
Shows module structures for each candidate in NRPS- and PKS regions. Genes are shown in predicted order, and are only present when containing at least one complete module. A domain glossary is available here.
Legend
Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
NRPS/PKS products
NRPS/PKS monomers
Predicted core structure(s)
Shows estimated product structure and polymer for each candidate cluster in the region. To show the product, click on the expander or the candidate cluster feature drawn in the overview.
For candidate cluster 2, location 49082 - 96210:
Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:
  (gly - thr)

Direct lookup in NORINE database: strict or relaxed
Link to NORINE database query form
NRPS/PKS monomer predictions
Shows the predicted monomers for each adynelation domain and acyltransferase within genes. Each gene prediction can be expanded to view detailed predictions of each domain. Each prediction can be expanded to view the predictions by tool (and, for some tools, further expanded for extra details).

ctg11_65: X
  Search NORINE for peptide: strict or relaxed
  AMP-binding (7..381): X
  NRPSPredictor2: (unknown)
  SVM prediction details:
    NOTE: outside applicability domain
    Predicted physicochemical class:
      hydrophobic-aliphatic
    Large clusters prediction:
      N/A
    Small clusters prediction:
      N/A
    Single AA prediction:
      N/A
  Stachelhaus prediction details:
    Stachelhaus sequence:
      sLYyLSffvK
    Nearest Stachelhaus code:
      cys
    Stachelhaus code match:
      50% (weak)
ctg11_76: dhb
  Search NORINE for peptide: strict or relaxed
  AMP-binding (30..435): dhb
  NRPSPredictor2: dhb
  SVM prediction details:
    Predicted physicochemical class:
      hydrophobic-aromatic
    Large clusters prediction:
      dhb, sal
    Small clusters prediction:
      dhb, sal
    Single AA prediction:
      dhb
  Stachelhaus prediction details:
    Stachelhaus sequence:
      PLPgQGVVNK
    Nearest Stachelhaus code:
      dhb
    Stachelhaus code match:
      90% (moderate)
ctg11_78: gly - thr
  Search NORINE for peptide: strict or relaxed
  AMP-binding (461..858): gly
  NRPSPredictor2: gly
  SVM prediction details:
    Predicted physicochemical class:
      hydrophobic-aliphatic
    Large clusters prediction:
      gly, ala, val, leu, ile, abu, iva
    Small clusters prediction:
      gly, ala
    Single AA prediction:
      gly
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DILQLGfIWK
    Nearest Stachelhaus code:
      gly
    Stachelhaus code match:
      90% (moderate)
  AMP-binding (1509..1920): thr
  NRPSPredictor2: thr
  SVM prediction details:
    Predicted physicochemical class:
      hydrophobic-aliphatic
    Large clusters prediction:
      ser, thr, dhpg, hpg
    Small clusters prediction:
      thr
    Single AA prediction:
      thr
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DFWNIGMVHK
    Nearest Stachelhaus code:
      thr
    Stachelhaus code match:
      100% (strong)

c00018_NZ_LWAG.. - Region 1 - LAP,RiPP-like
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 46,042 - 69,587 nt. (total: 23,546 nt) Show pHMM detection rules used
LAP: ((((goadsporin_like or PF00881 or TIGR03605) and (YcaO or TIGR03882 or TIGR03604)) or TIGR03603 or TIGR03602) and not cyanobactin_synth)
RiPP-like: (strepbact or Antimicrobial14 or Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or Lactococcin or Antimicrobial17 or Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or TIGR03975 or DUF692 or TIGR01193)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
MIBiG comparison
KnownClusterBlast
Pfam domains
TIGRFAM domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | LAP | RiPP-like | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | --- | ---
BGC0001174.1 |  |  | 0.53 | RiPP | corynazolicin | Corynebacterium urealyticum DSM 7111
BGC0000607.1 |  |  | 0.48 | RiPP | micrococcin P1 | Macrococcus caseolyticus
BGC0001171.1 |  |  | 0.40 | RiPP | listeriolysin S | Listeria monocytogenes serotype 4b str. F2365
BGC0002013.1 |  |  | 0.40 | RiPP | curacozole | Streptomyces curacoi
BGC0001146.1 |  |  | 0.39 | RiPP | cyclothiazomycin C | Streptomyces sp. NRRL WC-3908
BGC0000566.1 |  |  | 0.36 | RiPP | streptolysin S | Streptococcus pyogenes M1 GAS
BGC0000565.1 |  |  | 0.34 | RiPP | goadsporin | Streptomyces sp. TP-A0584
BGC0000483.1 |  |  | 0.33 | RiPP | aeruginosamide B, aeruginosamide C | Microcystis aeruginosa PCC 9432
BGC0001145.1 |  |  | 0.33 | RiPP | cyclothiazomycin b1 | Streptomyces mobaraensis NBRC 13819 = DSM 40847
BGC0000554.1 |  |  | 0.33 | RiPP | SRO15-3108 | Streptomyces filamentosus NRRL 15998

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000888.1 |  | 0.61 | Other | bacilysin | Bacillus sp. CS93
BGC0001184.1 |  | 0.61 | Other | bacilysin | Bacillus velezensis FZB42
BGC0001174.1 |  | 0.60 | RiPP | corynazolicin | Corynebacterium urealyticum DSM 7111
BGC0000607.1 |  | 0.59 | RiPP | micrococcin P1 | Macrococcus caseolyticus
BGC0002013.1 |  | 0.56 | RiPP | curacozole | Streptomyces curacoi
BGC0001171.1 |  | 0.54 | RiPP | listeriolysin S | Listeria monocytogenes serotype 4b str. F2365
BGC0000231.1 |  | 0.52 | Polyketide | griseusin | Streptomyces griseus
BGC0000565.1 |  | 0.52 | RiPP | goadsporin | Streptomyces sp. TP-A0584
BGC0001146.1 |  | 0.52 | RiPP | cyclothiazomycin C | Streptomyces sp. NRRL WC-3908
BGC0000566.1 |  | 0.51 | RiPP | streptolysin S | Streptococcus pyogenes M1 GAS

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.

No matches found.

Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
c00021_NZ_LWAG.. - Region 1 - T3PKS
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 1 - 35,020 nt. (total: 35,020 nt) Show pHMM detection rules used
Region on contig edge.
T3PKS: (Chal_sti_synt_C or Chal_sti_synt_N)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
MIBiG comparison
KnownClusterBlast
Pfam domains
TIGRFAM domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | T3PKS | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000282.1 |  | 0.35 | Polyketide | alkylresorcinol | Streptomyces griseus subsp. griseus NBRC 13350
BGC0001962.1 |  | 0.31 | Polyketide | hierridin B, hierridin C | Cyanobium sp. LEGE 06113
BGC0001938.1 |  | 0.31 | Polyketide | entotheonella | Candidatus Entotheonella serta
BGC0001831.1 |  | 0.22 | Polyketide | alkylpyrone-407, alkylpyrone-393 | Myxococcus xanthus DK 1622
BGC0001521.1 |  | 0.20 | NRP | auriculamide | Herpetosiphon aurantiacus DSM 785
BGC0001077.1 |  | 0.20 | Terpene, Polyketide | alkyl-O-dihydrogeranyl-methoxyhydroquinones | Actinoplanes missouriensis 431
BGC0001241.1 |  | 0.17 | Terpene | ergotamine | Claviceps fusiformis
BGC0001267.1 |  | 0.17 | Terpene | lysergic acid, elymoclavine | Claviceps fusiformis
BGC0001514.1 |  | 0.15 | Other | aristeromycin | Streptomyces citricolor
BGC0000811.1 |  | 0.15 | Alkaloid | fumigaclavine C | Aspergillus fumigatus Af293

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000282.1 |  | 0.68 | Polyketide | alkylresorcinol | Streptomyces griseus subsp. griseus NBRC 13350
BGC0001962.1 |  | 0.65 | Polyketide | hierridin B, hierridin C | Cyanobium sp. LEGE 06113
BGC0001938.1 |  | 0.64 | Polyketide | entotheonella | Candidatus Entotheonella serta
BGC0001831.1 |  | 0.55 | Polyketide | alkylpyrone-407, alkylpyrone-393 | Myxococcus xanthus DK 1622
BGC0001521.1 |  | 0.53 | NRP | auriculamide | Herpetosiphon aurantiacus DSM 785
BGC0001077.1 |  | 0.52 | Terpene, Polyketide | alkyl-O-dihydrogeranyl-methoxyhydroquinones | Actinoplanes missouriensis 431
BGC0001241.1 |  | 0.49 | Terpene | ergotamine | Claviceps fusiformis
BGC0001267.1 |  | 0.49 | Terpene | lysergic acid, elymoclavine | Claviceps fusiformis
BGC0001514.1 |  | 0.45 | Other | aristeromycin | Streptomyces citricolor
BGC0000811.1 |  | 0.45 | Alkaloid | fumigaclavine C | Aspergillus fumigatus Af293

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.

No matches found.

Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
c00025_NZ_LWAG.. - Region 1 - lanthipeptide-class-ii
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 2,886 - 31,369 nt. (total: 28,484 nt) Show pHMM detection rules used
lanthipeptide-class-ii: cds(LANC_like and DUF4135)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
MIBiG comparison
KnownClusterBlast
Lanthipeptides
Pfam domains
TIGRFAM domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | lanthipeptide-class-ii | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000503.1 |  | 0.34 | RiPP | cinnamycin | Streptomyces cinnamoneus
BGC0000528.1 |  | 0.34 | RiPP | michiganin A | Clavibacter michiganensis subsp. michiganensis NCPPB 382
BGC0001579.1 |  | 0.34 | RiPP | duramycin | Streptomyces cinnamoneus
BGC0000525.1 |  | 0.33 | RiPP | lichenicidin VK21 A1, lichenicidin VK21 A2 | Bacillus licheniformis
BGC0001229.1 |  | 0.31 | RiPP | SBI-06990 A1, SBI-06989 A2 | Streptomyces bingchenggensis BCW-1
BGC0000539.1 |  | 0.31 | RiPP | nukacin ISK-1 | Staphylococcus warneri
BGC0001787.1 |  | 0.30 | RiPP | suicin 3908 | Streptococcus suis
BGC0000554.1 |  | 0.29 | RiPP | SRO15-3108 | Streptomyces filamentosus NRRL 15998
BGC0000561.1 |  | 0.28 | RiPP | thermophilin 1277 | Streptococcus thermophilus
BGC0000521.1 |  | 0.28 | RiPP | lacticin 481 | Lactococcus lactis subsp. lactis

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000503.1 |  | 0.67 | RiPP | cinnamycin | Streptomyces cinnamoneus
BGC0000528.1 |  | 0.67 | RiPP | michiganin A | Clavibacter michiganensis subsp. michiganensis NCPPB 382
BGC0001579.1 |  | 0.67 | RiPP | duramycin | Streptomyces cinnamoneus
BGC0000525.1 |  | 0.66 | RiPP | lichenicidin VK21 A1, lichenicidin VK21 A2 | Bacillus licheniformis
BGC0001229.1 |  | 0.65 | RiPP | SBI-06990 A1, SBI-06989 A2 | Streptomyces bingchenggensis BCW-1
BGC0000539.1 |  | 0.64 | RiPP | nukacin ISK-1 | Staphylococcus warneri
BGC0001787.1 |  | 0.63 | RiPP | suicin 3908 | Streptococcus suis
BGC0000554.1 |  | 0.63 | RiPP | SRO15-3108 | Streptomyces filamentosus NRRL 15998
BGC0000561.1 |  | 0.62 | RiPP | thermophilin 1277 | Streptococcus thermophilus
BGC0000521.1 |  | 0.61 | RiPP | lacticin 481 | Lactococcus lactis subsp. lactis

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.

No matches found.

Lanthipeptide predictions
Lists the possible core peptides for each biosynthetic enzyme, including the predicted class. Each core peptide shows the leader and core peptide sequences, separated by a dash.

#### Lanthipeptide(s) for ctg25_15 - Putative Class II

ctg25_18 leader / core peptide
  MEERLYGFAGKLEEELEEIALKEISGG - AEQRGIDhaQGNDGHQC DhbIDhbWEC DhaICPDhbHDhb CWC
allorf_021729_021887 leader / core peptide
  MGFNSISFTINFYIFILIQIFSKFSERFHSENRILFA - VFDhbMIDCNNLHDhbAVR

#### Lanthipeptide(s) for ctg25_17 - Putative Class II

ctg25_18 leader / core peptide
  MEERLYGFAGKLEEELEEIALKEISGG - AEQRGIDhaQGNDGHQC DhbIDhbWEC DhaICPDhbHDhb CWC
allorf_021729_021887 leader / core peptide
  MGFNSISFTINFYIFILIQIFSKFSERFHSENRILFA - VFDhbMIDCNNLHDhbAVR
allorf_015893_016009 leader / core peptide
  LKKYQRKSNLDSHDSHFS - Dha DhaMPNNDhbMCINRIDhbMQRLKDha

#### Legend:

Dha: Didehydroalanine
Dhb: Didehydrobutyrine
Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
Lanthipeptides
Core peptide predictions
Lists the possible core peptides in the region. Each core peptide lists the number of lanthionine bridges, possible molecular weights, and the scores for cleavage site prediction and RODEO.

ctg25_18 - Class II
  Cleavage pHMM score: -2.20
  RODEO score: 0
  Monoisotopic mass: 3355.4 Da
  Molecular weight: 3357.7 Da
  Number of bridges: 5
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    3375.7 Da N = 1
allorf_021729_021887 - Class II
  Cleavage pHMM score: -6.50
  RODEO score: 0
  Monoisotopic mass: 1696.8 Da
  Molecular weight: 1698.0 Da
  Number of bridges: 1
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    1716.0 Da N = 1
ctg25_18 - Class II
  Cleavage pHMM score: -2.20
  RODEO score: 0
  Monoisotopic mass: 3355.4 Da
  Molecular weight: 3357.7 Da
  Number of bridges: 5
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    3375.7 Da N = 1
allorf_021729_021887 - Class II
  Cleavage pHMM score: -6.50
  RODEO score: 0
  Monoisotopic mass: 1696.8 Da
  Molecular weight: 1698.0 Da
  Number of bridges: 1
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    1716.0 Da N = 1
allorf_015893_016009 - Class II
  Cleavage pHMM score: -6.70
  RODEO score: 0
  Monoisotopic mass: 2234.1 Da
  Molecular weight: 2235.7 Da
  Number of bridges: 1
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    2253.7 Da N = 1
    2271.7 Da N = 2
    2289.7 Da N = 3
    2307.7 Da N = 4

c00029_NZ_LWAG.. - Region 1 - terpene
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 29,098 - 50,954 nt. (total: 21,857 nt) Show pHMM detection rules used
terpene: (Terpene_synth or Terpene_synth_C or phytoene_synt or Lycopene_cycl or terpene_cyclase or NapT7 or fung_ggpps or fung_ggpps2 or trichodiene_synth or TRI5)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
MIBiG comparison
KnownClusterBlast
Pfam domains
TIGRFAM domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | terpene | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001534.1 |  | 0.14 | Other | branched-chain fatty acids | Streptomyces filamentosus
BGC0000670.1 |  | 0.13 | Terpene | thalianol, thaliandiol | Arabidopsis thaliana
BGC0000627.1 |  | 0.07 | RiPP | ustiloxin B | Aspergillus flavus NRRL3357
BGC0001628.1 |  | 0.07 | NRP | JBIR-78, JBIR-95 | Kibdelosporangium sp. AK-AA56
BGC0001431.1 |  | 0.06 | NRP, Polyketide | myxochromide S | Stigmatella aurantiaca
BGC0001429.1 |  | 0.06 | NRP, Polyketide | myxochromide S1 | Stigmatella aurantiaca DW4/3-1
BGC0001567.1 |  | 0.05 | NRP | cysteoamide | Streptomyces lincolnensis
BGC0001650.1 |  | 0.05 | NRP | Le-pyrrolopyrazines | Lysobacter enzymogenes
BGC0002010.1 |  | 0.05 | NRP, Polyketide | streptophenazine B, streptophenazine C, streptophenazine F, streptophenazine G, streptophenazine H | Streptomyces sp. CNB091
BGC0001674.1 |  | 0.05 | RiPP | MS-271 | Streptomyces mirabilis

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001534.1 |  | 0.43 | Other | branched-chain fatty acids | Streptomyces filamentosus
BGC0000670.1 |  | 0.41 | Terpene | thalianol, thaliandiol | Arabidopsis thaliana
BGC0000627.1 |  | 0.29 | RiPP | ustiloxin B | Aspergillus flavus NRRL3357
BGC0001628.1 |  | 0.27 | NRP | JBIR-78, JBIR-95 | Kibdelosporangium sp. AK-AA56
BGC0001431.1 |  | 0.24 | NRP, Polyketide | myxochromide S | Stigmatella aurantiaca
BGC0001429.1 |  | 0.24 | NRP, Polyketide | myxochromide S1 | Stigmatella aurantiaca DW4/3-1
BGC0001567.1 |  | 0.24 | NRP | cysteoamide | Streptomyces lincolnensis
BGC0001650.1 |  | 0.23 | NRP | Le-pyrrolopyrazines | Lysobacter enzymogenes
BGC0002010.1 |  | 0.22 | NRP, Polyketide | streptophenazine B, streptophenazine C, streptophenazine F, streptophenazine G, streptophenazine H | Streptomyces sp. CNB091
BGC0001674.1 |  | 0.22 | RiPP | MS-271 | Streptomyces mirabilis

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.

No matches found.

Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
c00033_NZ_LWAG.. - Region 1 - terpene
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 148,311 - 169,129 nt. (total: 20,819 nt) Show pHMM detection rules used
terpene: (Terpene_synth or Terpene_synth_C or phytoene_synt or Lycopene_cycl or terpene_cyclase or NapT7 or fung_ggpps or fung_ggpps2 or trichodiene_synth or TRI5)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
MIBiG comparison
KnownClusterBlast
Pfam domains
TIGRFAM domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | terpene | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001839.1 |  | 0.32 | Terpene | squalestatin S1 | Aspergillus sp. Z5
BGC0000846.1 |  | 0.16 | Other | tabtoxin | Pseudomonas syringae
BGC0001935.1 |  | 0.15 | Other | 3,7-dihydroxytropolone | Streptomyces cyaneofuscatus
BGC0001487.1 |  | 0.15 | Other | 3,7-dihydroxytropolone | Streptomyces cyaneofuscatus
BGC0001783.1 |  | 0.14 | Other | streptonigrin | Streptomyces flocculus
BGC0001387.1 |  | 0.14 | Other | nucleocidin | Streptomyces calvus
BGC0001607.1 |  | 0.14 | Other | gilvusmycin | Streptomyces sp. NRRL B-1347
BGC0001540.1 |  | 0.14 | Other | CC-1065 | Streptomyces zelensis
BGC0000923.1 |  | 0.14 | Other | paerucumarin | Pseudomonas aeruginosa PAO1
BGC0000196.1 |  | 0.13 | Polyketide | AQ-256, AQ-270a, AQ-284a | Photorhabdus laumondii subsp. laumondii TTO1

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001839.1 |  | 0.65 | Terpene | squalestatin S1 | Aspergillus sp. Z5
BGC0000846.1 |  | 0.47 | Other | tabtoxin | Pseudomonas syringae
BGC0001935.1 |  | 0.46 | Other | 3,7-dihydroxytropolone | Streptomyces cyaneofuscatus
BGC0001487.1 |  | 0.46 | Other | 3,7-dihydroxytropolone | Streptomyces cyaneofuscatus
BGC0001783.1 |  | 0.43 | Other | streptonigrin | Streptomyces flocculus
BGC0001387.1 |  | 0.43 | Other | nucleocidin | Streptomyces calvus
BGC0001607.1 |  | 0.43 | Other | gilvusmycin | Streptomyces sp. NRRL B-1347
BGC0001540.1 |  | 0.43 | Other | CC-1065 | Streptomyces zelensis
BGC0000923.1 |  | 0.43 | Other | paerucumarin | Pseudomonas aeruginosa PAO1
BGC0000196.1 |  | 0.42 | Polyketide | AQ-256, AQ-270a, AQ-284a | Photorhabdus laumondii subsp. laumondii TTO1

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.

No matches found.

Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
c00035_NZ_LWAG.. - Region 1 - NRPS,T1PKS
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 19,233 - 89,094 nt. (total: 69,862 nt) Show pHMM detection rules used
NRPS: cds(Condensation and (AMP-binding or A-OX))
T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
NRPS/PKS domains
MIBiG comparison
KnownClusterBlast
NRPS/PKS modules
Pfam domains
TIGRFAM domains
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
A glossary is available here.
Selected features only
Show module domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | NRPS | T1PKS | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | --- | ---
BGC0001050.1 |  |  | 0.74 | NRP, Polyketide | thalassospiramide A | Tistrella bauzanensis
BGC0000427.1 |  |  | 0.70 | NRP | shinorine, 4-deoxygadusol, mycosporine glycine | Trichormus variabilis ATCC 29413
BGC0000979.1 |  |  | 0.69 | NRP, Polyketide | cylindrospermopsin | Aphanizomenon sp. 10E9
BGC0000980.1 |  |  | 0.69 | NRP, Polyketide | cylindrospermopsin | Aphanizomenon sp. 22D11
BGC0001479.1 |  |  | 0.67 | NRP | anabaenopeptin NZ857, nostamide A | Nostoc punctiforme PCC 73102
BGC0001023.1 |  |  | 0.64 | NRP, Polyketide | myxochromide S1 | Stigmatella aurantiaca
BGC0001249.1 |  |  | 0.63 | NRP | dimethylcoprogen | Alternaria alternata
BGC0000901.1 |  |  | 0.63 | Other | ferrichrome | Aspergillus niger
BGC0000900.1 |  |  | 0.63 | Other | ferrichrome | Aspergillus oryzae
BGC0001261.1 |  |  | 0.62 | NRP | AM-toxin | Alternaria alternata

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001050.1 |  | 0.70 | NRP, Polyketide | thalassospiramide A | Tistrella bauzanensis
BGC0000427.1 |  | 0.68 | NRP | shinorine, 4-deoxygadusol, mycosporine glycine | Trichormus variabilis ATCC 29413
BGC0000979.1 |  | 0.67 | NRP, Polyketide | cylindrospermopsin | Aphanizomenon sp. 10E9
BGC0000980.1 |  | 0.67 | NRP, Polyketide | cylindrospermopsin | Aphanizomenon sp. 22D11
BGC0001479.1 |  | 0.67 | NRP | anabaenopeptin NZ857, nostamide A | Nostoc punctiforme PCC 73102
BGC0000375.1 |  | 0.66 | NRP | indigoidine | Streptomyces chromofuscus
BGC0001023.1 |  | 0.65 | NRP, Polyketide | myxochromide S1 | Stigmatella aurantiaca
BGC0001249.1 |  | 0.65 | NRP | dimethylcoprogen | Alternaria alternata
BGC0000901.1 |  | 0.65 | Other | ferrichrome | Aspergillus niger
BGC0000900.1 |  | 0.65 | Other | ferrichrome | Aspergillus oryzae

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.
Module view
Shows module structures for each candidate in NRPS- and PKS regions. Genes are shown in predicted order, and are only present when containing at least one complete module. A domain glossary is available here.
Legend
Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
NRPS/PKS products
NRPS/PKS monomers
Predicted core structure(s)
Shows estimated product structure and polymer for each candidate cluster in the region. To show the product, click on the expander or the candidate cluster feature drawn in the overview.
For candidate cluster 1, location 19232 - 89094:
Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:
  (X - gln) + (mal) + (D-asn) + (D-X - X - asp)

Direct lookup in NORINE database: strict or relaxed
Link to NORINE database query form
NRPS/PKS monomer predictions
Shows the predicted monomers for each adynelation domain and acyltransferase within genes. Each gene prediction can be expanded to view detailed predictions of each domain. Each prediction can be expanded to view the predictions by tool (and, for some tools, further expanded for extra details).

ctg35_34: X
  Search NORINE for peptide: strict or relaxed
  AMP-binding (36..428): X
  NRPSPredictor2: hydrophobic-aliphatic
  SVM prediction details:
    Predicted physicochemical class:
      hydrophobic-aliphatic
    Large clusters prediction:
      N/A
    Small clusters prediction:
      N/A
    Single AA prediction:
      N/A
  Stachelhaus prediction details:
    Stachelhaus sequence:
      gmvIVGgpiK
    Nearest Stachelhaus code:
      lys-b
    Stachelhaus code match:
      40% (weak)
ctg35_46: X - X - asp
  Search NORINE for peptide: strict or relaxed
  AMP-binding (467..859): X
  NRPSPredictor2: asp, asn, glu, gln, aad
  SVM prediction details:
    Predicted physicochemical class:
      hydrophilic
    Large clusters prediction:
      asp, asn, glu, gln, aad
    Small clusters prediction:
      N/A
    Single AA prediction:
      N/A
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DpenIGnVDK
    Nearest Stachelhaus code:
      glu
    Stachelhaus code match:
      60% (weak)
  AMP-binding (1980..2388): X
  NRPSPredictor2: asp, asn, glu, gln, aad
  SVM prediction details:
    Predicted physicochemical class:
      hydrophilic
    Large clusters prediction:
      asp, asn, glu, gln, aad
    Small clusters prediction:
      N/A
    Single AA prediction:
      N/A
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DiEnIGamtK
    Nearest Stachelhaus code:
      lys
    Stachelhaus code match:
      50% (weak)
  AMP-binding (3033..3436): asp
  NRPSPredictor2: asp
  SVM prediction details:
    Predicted physicochemical class:
      hydrophilic
    Large clusters prediction:
      asp, asn, glu, gln, aad
    Small clusters prediction:
      asp, asn
    Single AA prediction:
      asp
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DLTKVGHIGK
    Nearest Stachelhaus code:
      asp
    Stachelhaus code match:
      100% (strong)
ctg35_48: asn
  Search NORINE for peptide: strict or relaxed
  AMP-binding (457..851): asn
  NRPSPredictor2: asn
  SVM prediction details:
    Predicted physicochemical class:
      hydrophilic
    Large clusters prediction:
      asp, asn, glu, gln, aad
    Small clusters prediction:
      asp, asn
    Single AA prediction:
      asn
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DLTKIGEVGK
    Nearest Stachelhaus code:
      asn
    Stachelhaus code match:
      100% (strong)
ctg35_49: mal
  PKS_AT (531..823): mal
  ATSignature: Malonyl-CoA
  Top 3 matches:
    Malonyl-CoA: 91.7%
    inactive: 87.5%
    2-Rhyd-Malonyl-CoA: 58.3%
  minowa: Malonyl-CoA
  Prediction, score:
    Malonyl-CoA: 140.1
    inactive: 112.6
    Methoxymalonyl-CoA: 51.7
    Methylmalonyl-CoA: 43.2
    Propionyl-CoA: 28.3
    Acetyl-CoA: 12.4
    2-Methylbutyryl-CoA: 11.9
    CHC-CoA: 9.9
    Isobutyryl-CoA: 9.6
    Benzoyl-CoA: 9.2
    trans-1,2-CPDA: 0.0
    fatty_acid: 0.0
    Ethylmalonyl-CoA: 0.0
    3-Methylbutyryl-CoA: 0.0
ctg35_50: X - gln
  Search NORINE for peptide: strict or relaxed
  AMP-binding (260..663): X
  NRPSPredictor2: (unknown)
  SVM prediction details:
    NOTE: outside applicability domain
    Predicted physicochemical class:
      hydrophilic
    Large clusters prediction:
      asp, asn, glu, gln, aad
    Small clusters prediction:
      N/A
    Single AA prediction:
      N/A
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DTknfGTdiK
    Nearest Stachelhaus code:
      lys-b
    Stachelhaus code match:
      50% (weak)
  AMP-binding (1308..1702): gln
  NRPSPredictor2: gln
  SVM prediction details:
    Predicted physicochemical class:
      hydrophilic
    Large clusters prediction:
      asp, asn, glu, gln, aad
    Small clusters prediction:
      glu, gln
    Single AA prediction:
      gln
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DAQDiGiVnK
    Nearest Stachelhaus code:
      gln
    Stachelhaus code match:
      70% (weak)

c00052_NZ_LWAG.. - Region 1 - betalactone
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 1 - 16,073 nt. (total: 16,073 nt) Show pHMM detection rules used
Region on contig edge.
betalactone: (HMGL-like and AMP-binding)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
MIBiG comparison
KnownClusterBlast
Pfam domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | betalactone | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001778.1 |  | 0.26 | Other | showdomycin | Streptomyces showdoensis
BGC0000234.1 |  | 0.19 | Polyketide | jadomycin | Streptomyces venezuelae ATCC 10712
BGC0000259.1 |  | 0.18 | Polyketide | prodigiosin | Serratia marcescens
BGC0000260.1 |  | 0.16 | Polyketide | prodigiosin | Hahella chejuensis KCTC 2396
BGC0000207.1 |  | 0.16 | Polyketide | chartreusin | Streptomyces chartreusis
BGC0000003.1 |  | 0.16 | Polyketide | AF-toxin | Alternaria alternata
BGC0000706.1 |  | 0.16 | Saccharide | kanamycin | Streptomyces kanamyceticus
BGC0001262.1 |  | 0.15 | Polyketide | AK-toxin I | Alternaria alternata
BGC0000131.1 |  | 0.15 | Polyketide | pyrrolomycin | Streptomyces sp. UC 11065
BGC0000243.1 |  | 0.15 | Polyketide | macrotetrolide | Streptomyces griseus subsp. griseus

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001778.1 |  | 0.60 | Other | showdomycin | Streptomyces showdoensis
BGC0000234.1 |  | 0.50 | Polyketide | jadomycin | Streptomyces venezuelae ATCC 10712
BGC0000259.1 |  | 0.49 | Polyketide | prodigiosin | Serratia marcescens
BGC0000260.1 |  | 0.47 | Polyketide | prodigiosin | Hahella chejuensis KCTC 2396
BGC0000207.1 |  | 0.46 | Polyketide | chartreusin | Streptomyces chartreusis
BGC0000003.1 |  | 0.46 | Polyketide | AF-toxin | Alternaria alternata
BGC0000706.1 |  | 0.46 | Saccharide | kanamycin | Streptomyces kanamyceticus
BGC0001262.1 |  | 0.45 | Polyketide | AK-toxin I | Alternaria alternata
BGC0000131.1 |  | 0.45 | Polyketide | pyrrolomycin | Streptomyces sp. UC 11065
BGC0000243.1 |  | 0.45 | Polyketide | macrotetrolide | Streptomyces griseus subsp. griseus

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.
Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
c00053_NZ_LWAG.. - Region 1 - NRPS
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 4,537 - 70,450 nt. (total: 65,914 nt) Show pHMM detection rules used
NRPS: cds(Condensation and (AMP-binding or A-OX))

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
NRPS/PKS domains
MIBiG comparison
KnownClusterBlast
NRPS/PKS modules
Pfam domains
TIGRFAM domains
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
A glossary is available here.
Selected features only
Show module domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | NRPS | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000389.1 |  | 0.43 | NRP | massetolide A | Pseudomonas fluorescens SS101
BGC0000438.1 |  | 0.37 | NRP | syringopeptin 25A | Pseudomonas syringae pv. syringae
BGC0001615.1 |  | 0.35 | NRP | hexose-palythine-serine, hexose-shinorine | Heteroscytonema crispum UCFS10
BGC0000417.1 |  | 0.35 | NRP | rhodochelin | Rhodococcus jostii RHA1
BGC0001833.1 |  | 0.35 | NRP | icosalide A, icosalide B | Burkholderia gladioli
BGC0000426.1 |  | 0.34 | NRP | sevadicin | Paenibacillus larvae
BGC0000465.1 |  | 0.34 | NRP | xenortide A, xenortide B, xenortide C, xenortide D | Xenorhabdus nematophila ATCC 19061
BGC0001844.1 |  | 0.33 | NRP | holrhizin | Paraburkholderia rhizoxinica HKI 454
BGC0001890.1 |  | 0.33 | NRP | amphi-enterobactin 1, amphi-enterobactin 2, amphi-enterobactin 3, amphi-enterobactin 4 | Vibrio campbellii ATCC BAA-1116
BGC0001131.1 |  | 0.32 | NRP | ambactin | Xenorhabdus miraniensis

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000389.1 |  | 0.74 | NRP | massetolide A | Pseudomonas fluorescens SS101
BGC0000438.1 |  | 0.70 | NRP | syringopeptin 25A | Pseudomonas syringae pv. syringae
BGC0001615.1 |  | 0.68 | NRP | hexose-palythine-serine, hexose-shinorine | Heteroscytonema crispum UCFS10
BGC0000417.1 |  | 0.68 | NRP | rhodochelin | Rhodococcus jostii RHA1
BGC0001833.1 |  | 0.68 | NRP | icosalide A, icosalide B | Burkholderia gladioli
BGC0000426.1 |  | 0.67 | NRP | sevadicin | Paenibacillus larvae
BGC0000465.1 |  | 0.67 | NRP | xenortide A, xenortide B, xenortide C, xenortide D | Xenorhabdus nematophila ATCC 19061
BGC0001844.1 |  | 0.66 | NRP | holrhizin | Paraburkholderia rhizoxinica HKI 454
BGC0001890.1 |  | 0.66 | NRP | amphi-enterobactin 1, amphi-enterobactin 2, amphi-enterobactin 3, amphi-enterobactin 4 | Vibrio campbellii ATCC BAA-1116
BGC0001131.1 |  | 0.66 | NRP | ambactin | Xenorhabdus miraniensis

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.

No matches found.

Module view
Shows module structures for each candidate in NRPS- and PKS regions. Genes are shown in predicted order, and are only present when containing at least one complete module. A domain glossary is available here.
Legend
Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
NRPS/PKS products
NRPS/PKS monomers
Predicted core structure(s)
Shows estimated product structure and polymer for each candidate cluster in the region. To show the product, click on the expander or the candidate cluster feature drawn in the overview.
For candidate cluster 1, location 4536 - 70450:
Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:
  (D-thr) + (X - ala) + (ser - leu - D-gln - glu)

Direct lookup in NORINE database: strict or relaxed
Link to NORINE database query form
NRPS/PKS monomer predictions
Shows the predicted monomers for each adynelation domain and acyltransferase within genes. Each gene prediction can be expanded to view detailed predictions of each domain. Each prediction can be expanded to view the predictions by tool (and, for some tools, further expanded for extra details).

ctg53_23: thr
  Search NORINE for peptide: strict or relaxed
  AMP-binding (457..866): thr
  NRPSPredictor2: thr
  SVM prediction details:
    Predicted physicochemical class:
      hydrophobic-aliphatic
    Large clusters prediction:
      ser, thr, dhpg, hpg
    Small clusters prediction:
      thr
    Single AA prediction:
      thr
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DFWNIGMVHK
    Nearest Stachelhaus code:
      thr
    Stachelhaus code match:
      100% (strong)
ctg53_24: X - ala
  Search NORINE for peptide: strict or relaxed
  AMP-binding (466..870): X
  NRPSPredictor2: hydrophobic-aliphatic
  SVM prediction details:
    Predicted physicochemical class:
      hydrophobic-aliphatic
    Large clusters prediction:
      N/A
    Small clusters prediction:
      N/A
    Single AA prediction:
      N/A
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DvWQFGfIyK
    Nearest Stachelhaus code:
      gln
    Stachelhaus code match:
      70% (weak)
  AMP-binding (1527..1919): ala
  NRPSPredictor2: ala
  SVM prediction details:
    Predicted physicochemical class:
      hydrophobic-aliphatic
    Large clusters prediction:
      gly, ala, val, leu, ile, abu, iva
    Small clusters prediction:
      gly, ala
    Single AA prediction:
      ala
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DLFNNALTYK
    Nearest Stachelhaus code:
      ala
    Stachelhaus code match:
      100% (strong)
ctg53_25: ser - leu - gln - glu
  Search NORINE for peptide: strict or relaxed
  AMP-binding (496..901): ser
  NRPSPredictor2: ser
  SVM prediction details:
    Predicted physicochemical class:
      hydrophobic-aliphatic
    Large clusters prediction:
      ser, thr, dhpg, hpg
    Small clusters prediction:
      ser
    Single AA prediction:
      ser
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DVWHFSLVDK
    Nearest Stachelhaus code:
      ser
    Stachelhaus code match:
      100% (strong)
  AMP-binding (1558..1945): leu
  NRPSPredictor2: leu
  SVM prediction details:
    Predicted physicochemical class:
      hydrophobic-aliphatic
    Large clusters prediction:
      gly, ala, val, leu, ile, abu, iva
    Small clusters prediction:
      val, leu, ile, abu, iva
    Single AA prediction:
      leu
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DsQFIgqVVK
    Nearest Stachelhaus code:
      pro
    Stachelhaus code match:
      70% (weak)
  AMP-binding (2600..3000): gln
  NRPSPredictor2: gln
  SVM prediction details:
    Predicted physicochemical class:
      N/A
    Large clusters prediction:
      N/A
    Small clusters prediction:
      N/A
    Single AA prediction:
      N/A
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DviDLGVVDK
    Nearest Stachelhaus code:
      gln
    Stachelhaus code match:
      80% (moderate)
  AMP-binding (4116..4516): glu
  NRPSPredictor2: glu
  SVM prediction details:
    Predicted physicochemical class:
      hydrophilic
    Large clusters prediction:
      asp, asn, glu, gln, aad
    Small clusters prediction:
      N/A
    Single AA prediction:
      N/A
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DsKDLGVVDK
    Nearest Stachelhaus code:
      glu
    Stachelhaus code match:
      90% (moderate)

c00057_NZ_LWAG.. - Region 1 - siderophore
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 1 - 13,391 nt. (total: 13,391 nt) Show pHMM detection rules used
Region on contig edge.
siderophore: IucA_IucC

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
MIBiG comparison
KnownClusterBlast
Pfam domains
TIGRFAM domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | siderophore | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001572.1 |  | 0.28 | Other | desferrioxamine E | Pantoea agglomerans
BGC0001478.1 |  | 0.28 | Other | desferrioxamine E | Streptomyces sp. ID38640
BGC0000941.1 |  | 0.26 | Other | desferrioxamin B | Streptomyces griseus subsp. griseus NBRC 13350
BGC0000855.1 |  | 0.25 | Other | ectoine | Methylomicrobium kenyense
BGC0000852.1 |  | 0.25 | Other | ectoine | Sporosarcina pasteurii
BGC0000858.1 |  | 0.25 | Other | ectoine | Methylobacter marinus
BGC0000853.1 |  | 0.25 | Other | ectoine | Streptomyces anulatus
BGC0000859.1 |  | 0.25 | Other | ectoine | Methylomicrobium alcaliphilum
BGC0000856.1 |  | 0.25 | Other | ectoine | Methylophaga thalassica
BGC0000939.1 |  | 0.24 | Other | aerobactin | Grimontia hollisae

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001572.1 |  | 0.62 | Other | desferrioxamine E | Pantoea agglomerans
BGC0001478.1 |  | 0.61 | Other | desferrioxamine E | Streptomyces sp. ID38640
BGC0000941.1 |  | 0.59 | Other | desferrioxamin B | Streptomyces griseus subsp. griseus NBRC 13350
BGC0000855.1 |  | 0.59 | Other | ectoine | Methylomicrobium kenyense
BGC0000852.1 |  | 0.59 | Other | ectoine | Sporosarcina pasteurii
BGC0000858.1 |  | 0.58 | Other | ectoine | Methylobacter marinus
BGC0000853.1 |  | 0.58 | Other | ectoine | Streptomyces anulatus
BGC0000859.1 |  | 0.58 | Other | ectoine | Methylomicrobium alcaliphilum
BGC0000856.1 |  | 0.58 | Other | ectoine | Methylophaga thalassica
BGC0000939.1 |  | 0.57 | Other | aerobactin | Grimontia hollisae

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.

No matches found.

Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
c00057_NZ_LWAG.. - Region 2 - RRE-containing
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 15,011 - 32,514 nt. (total: 17,504 nt) Show pHMM detection rules used
Region on contig edge.
RRE-containing: minimum(1, [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE, Cytolysin_C_RRE, Goadsporin_CD_RRE, Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE, Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE, Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE, Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE, Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE, Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE, Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE, Thiaglutamate_B_RRE, Thiaglutamate_G_RRE, Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE, Thurincin_rSAM_RRE, Trifolitoxin_RRE])

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
MIBiG comparison
KnownClusterBlast
Pfam domains
TIGRFAM domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | RRE-containing | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000585.1 |  | 0.20 | RiPP | microcin C7 | Escherichia coli
BGC0000812.1 |  | 0.14 | Alkaloid | huperzine A | Shiraia sp. slf14
BGC0001796.1 |  | 0.07 | NRP | tauramamide | Brevibacillus laterosporus DSM 25
BGC0000453.1 |  | 0.06 | NRP | valinomycin | Streptomyces tsusimaensis
BGC0001650.1 |  | 0.05 | NRP | Le-pyrrolopyrazines | Lysobacter enzymogenes
BGC0001148.1 |  | 0.04 | NRP, RiPP | pheganomycin | Streptomyces cirratus
BGC0000274.1 |  | 0.04 | Polyketide | tetarimycin A, tetarimycin B | uncultured bacterium
BGC0000406.1 |  | 0.03 | NRP | phosphinothricintripeptide | Streptomyces viridochromogenes

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000585.1 |  | 0.53 | RiPP | microcin C7 | Escherichia coli
BGC0000812.1 |  | 0.43 | Alkaloid | huperzine A | Shiraia sp. slf14
BGC0001796.1 |  | 0.29 | NRP | tauramamide | Brevibacillus laterosporus DSM 25
BGC0000453.1 |  | 0.24 | NRP | valinomycin | Streptomyces tsusimaensis
BGC0001650.1 |  | 0.23 | NRP | Le-pyrrolopyrazines | Lysobacter enzymogenes
BGC0001148.1 |  | 0.20 | NRP, RiPP | pheganomycin | Streptomyces cirratus
BGC0000274.1 |  | 0.19 | Polyketide | tetarimycin A, tetarimycin B | uncultured bacterium
BGC0000406.1 |  | 0.17 | NRP | phosphinothricintripeptide | Streptomyces viridochromogenes

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.

No matches found.

Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
c00077_NZ_LWAG.. - Region 1 - NRPS
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 3,189 - 34,988 nt. (total: 31,800 nt) Show pHMM detection rules used
Region on contig edge.
NRPS: cds(Condensation and (AMP-binding or A-OX))

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
NRPS/PKS domains
MIBiG comparison
KnownClusterBlast
NRPS/PKS modules
Pfam domains
TIGRFAM domains
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
A glossary is available here.
Selected features only
Show module domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | NRPS | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001561.1 |  | 0.28 | NRP | curacomycin | Streptomyces curacoi
BGC0001479.1 |  | 0.27 | NRP | anabaenopeptin NZ857, nostamide A | Nostoc punctiforme PCC 73102
BGC0001132.1 |  | 0.24 | NRP | xenotetrapeptide | Xenorhabdus nematophila ATCC 19061
BGC0001128.1 |  | 0.23 | NRP | luminmide | Photorhabdus laumondii subsp. laumondii TTO1
BGC0000347.1 |  | 0.23 | NRP | equibactin | Streptococcus equi subsp. equi
BGC0001135.1 |  | 0.23 | NRP | bicornutin A1, bicornutin A2 | Xenorhabdus budapestensis
BGC0000373.1 |  | 0.22 | NRP | holomycin | Streptomyces clavuligerus ATCC 27064
BGC0000410.1 |  | 0.22 | NRP | pseudomonine | Pseudomonas fluorescens
BGC0001641.1 |  | 0.22 | NRP | kolossin | Photorhabdus laumondii subsp. laumondii TTO1
BGC0000308.1 |  | 0.21 | NRP | aureusimine | Staphylococcus aureus subsp. aureus str. JKD6008

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001561.1 |  | 0.61 | NRP | curacomycin | Streptomyces curacoi
BGC0001479.1 |  | 0.60 | NRP | anabaenopeptin NZ857, nostamide A | Nostoc punctiforme PCC 73102
BGC0001132.1 |  | 0.57 | NRP | xenotetrapeptide | Xenorhabdus nematophila ATCC 19061
BGC0001128.1 |  | 0.56 | NRP | luminmide | Photorhabdus laumondii subsp. laumondii TTO1
BGC0000347.1 |  | 0.56 | NRP | equibactin | Streptococcus equi subsp. equi
BGC0001135.1 |  | 0.56 | NRP | bicornutin A1, bicornutin A2 | Xenorhabdus budapestensis
BGC0000373.1 |  | 0.55 | NRP | holomycin | Streptomyces clavuligerus ATCC 27064
BGC0000410.1 |  | 0.55 | NRP | pseudomonine | Pseudomonas fluorescens
BGC0001641.1 |  | 0.54 | NRP | kolossin | Photorhabdus laumondii subsp. laumondii TTO1
BGC0000308.1 |  | 0.54 | NRP | aureusimine | Staphylococcus aureus subsp. aureus str. JKD6008

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.

No matches found.

Module view
Shows module structures for each candidate in NRPS- and PKS regions. Genes are shown in predicted order, and are only present when containing at least one complete module. A domain glossary is available here.
Legend
Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
NRPS/PKS products
NRPS/PKS monomers
Predicted core structure(s)
Shows estimated product structure and polymer for each candidate cluster in the region. To show the product, click on the expander or the candidate cluster feature drawn in the overview.
For candidate cluster 1, location 3188 - 34988:
Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:
  (X - cys)

Direct lookup in NORINE database: strict or relaxed
Link to NORINE database query form
NRPS/PKS monomer predictions
Shows the predicted monomers for each adynelation domain and acyltransferase within genes. Each gene prediction can be expanded to view detailed predictions of each domain. Each prediction can be expanded to view the predictions by tool (and, for some tools, further expanded for extra details).

ctg77_25: X - cys
  Search NORINE for peptide: strict or relaxed
  AMP-binding (266..656): X
  NRPSPredictor2: hydrophobic-aliphatic
  SVM prediction details:
    Predicted physicochemical class:
      hydrophobic-aliphatic
    Large clusters prediction:
      N/A
    Small clusters prediction:
      N/A
    Single AA prediction:
      N/A
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DILeLaiIcK
    Nearest Stachelhaus code:
      gly
    Stachelhaus code match:
      60% (weak)
  AMP-binding (1303..1683): cys
  NRPSPredictor2: cys
  SVM prediction details:
    Predicted physicochemical class:
      hydrophobic-aliphatic
    Large clusters prediction:
      cys
    Small clusters prediction:
      cys
    Single AA prediction:
      cys
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DLYNLSLIWK
    Nearest Stachelhaus code:
      cys
    Stachelhaus code match:
      100% (strong)

c00081_NZ_LWAG.. - Region 1 - lanthipeptide-class-ii
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 1 - 13,936 nt. (total: 13,936 nt) Show pHMM detection rules used
Region on contig edge.
lanthipeptide-class-ii: cds(LANC_like and DUF4135)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
MIBiG comparison
KnownClusterBlast
Lanthipeptides
Pfam domains
TIGRFAM domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | lanthipeptide-class-ii | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000554.1 |  | 0.33 | RiPP | SRO15-3108 | Streptomyces filamentosus NRRL 15998
BGC0000525.1 |  | 0.25 | RiPP | lichenicidin VK21 A1, lichenicidin VK21 A2 | Bacillus licheniformis
BGC0000504.1 |  | 0.25 | RiPP | cytolysin ClyLl, cytolysin ClyLs | Plasmid pAD1
BGC0000626.1 |  | 0.24 | RiPP | thuricin | Bacillus thuringiensis
BGC0000500.1 |  | 0.23 | RiPP | carnolysin A1, carnolysin A2 | Carnobacterium maltaromaticum
BGC0000528.1 |  | 0.23 | RiPP | michiganin A | Clavibacter michiganensis subsp. michiganensis NCPPB 382
BGC0000539.1 |  | 0.23 | RiPP | nukacin ISK-1 | Staphylococcus warneri
BGC0000558.1 |  | 0.23 | RiPP | sublancin 168 | Bacillus subtilis subsp. subtilis str. 168
BGC0001863.1 |  | 0.20 | RiPP, Terpene | bacillicn CER074 | Bacillus mycoides
BGC0000521.1 |  | 0.20 | RiPP | lacticin 481 | Lactococcus lactis subsp. lactis

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000554.1 |  | 0.66 | RiPP | SRO15-3108 | Streptomyces filamentosus NRRL 15998
BGC0000525.1 |  | 0.59 | RiPP | lichenicidin VK21 A1, lichenicidin VK21 A2 | Bacillus licheniformis
BGC0000504.1 |  | 0.58 | RiPP | cytolysin ClyLl, cytolysin ClyLs | Plasmid pAD1
BGC0000626.1 |  | 0.57 | RiPP | thuricin | Bacillus thuringiensis
BGC0000500.1 |  | 0.56 | RiPP | carnolysin A1, carnolysin A2 | Carnobacterium maltaromaticum
BGC0000528.1 |  | 0.56 | RiPP | michiganin A | Clavibacter michiganensis subsp. michiganensis NCPPB 382
BGC0000539.1 |  | 0.56 | RiPP | nukacin ISK-1 | Staphylococcus warneri
BGC0000558.1 |  | 0.56 | RiPP | sublancin 168 | Bacillus subtilis subsp. subtilis str. 168
BGC0001863.1 |  | 0.53 | RiPP, Terpene | bacillicn CER074 | Bacillus mycoides
BGC0000521.1 |  | 0.53 | RiPP | lacticin 481 | Lactococcus lactis subsp. lactis

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.

No matches found.

Lanthipeptide predictions
Lists the possible core peptides for each biosynthetic enzyme, including the predicted class. Each core peptide shows the leader and core peptide sequences, separated by a dash.

#### Lanthipeptide(s) for ctg81_4 - Putative Class II

ctg81_3 leader / core peptide
  LTGNHGISPVGRSLKNLSEEEMRSIFGG - DhaGMDAEARDha DhbLICGAGIDhaLIGDhaYLADhaAAFKCGKDNKGK

#### Legend:

Dha: Didehydroalanine
Dhb: Didehydrobutyrine
Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
Lanthipeptides
Core peptide predictions
Lists the possible core peptides in the region. Each core peptide lists the number of lanthionine bridges, possible molecular weights, and the scores for cleavage site prediction and RODEO.

ctg81_3 - Class II
  Cleavage pHMM score: 2.50
  RODEO score: 0
  Monoisotopic mass: 3681.9 Da
  Molecular weight: 3684.2 Da
  Number of bridges: 2
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    3702.2 Da N = 1
    3720.2 Da N = 2
    3738.3 Da N = 3
    3756.3 Da N = 4