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Overview
1.1
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1.5

### Identified secondary metabolite regions using strictness 'relaxed'

NZ_CP023011.2

Region | Type | From | To | Most similar known cluster | Similarity
--- | --- | --- | --- | --- | ---
Region 1 | cyclic-lactone-autoinducer | 303,953 | 316,632 |
Region 2 | terpene | 757,945 | 778,814 |
Region 3 | lanthipeptide-class-ii | 795,732 | 818,635 |
Region 4 | cyclic-lactone-autoinducer | 1,970,912 | 1,991,650 |
Region 5 | T3PKS | 2,454,477 | 2,495,628 |

NZ_CP023011.2 - Region 1 - cyclic-lactone-autoinducer
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 303,953 - 316,632 nt. (total: 12,680 nt) Show pHMM detection rules used
cyclic-lactone-autoinducer: (TIGR04223 or AgrB)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
MIBiG comparison
KnownClusterBlast
Pfam domains
TIGRFAM domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | cyclic-lactone-autoinducer | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001291.1 |  | 0.18 | RiPP | enterocin NKR-5-3B | Enterococcus faecium
BGC0000494.1 |  | 0.16 | RiPP | uberolysin | Streptococcus uberis
BGC0000540.1 |  | 0.09 | RiPP | paenibacillin | Paenibacillus polymyxa OSY-DF
BGC0000624.1 |  | 0.08 | RiPP | salivaricin CRL1328 α peptide, salivaricin CRL1328 β peptide | Lactobacillus salivarius

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001291.1 |  | 0.49 | RiPP | enterocin NKR-5-3B | Enterococcus faecium
BGC0000494.1 |  | 0.46 | RiPP | uberolysin | Streptococcus uberis
BGC0000540.1 |  | 0.34 | RiPP | paenibacillin | Paenibacillus polymyxa OSY-DF
BGC0000624.1 |  | 0.32 | RiPP | salivaricin CRL1328 α peptide, salivaricin CRL1328 β peptide | Lactobacillus salivarius

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.

No matches found.

Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
NZ_CP023011.2 - Region 2 - terpene
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 757,945 - 778,814 nt. (total: 20,870 nt) Show pHMM detection rules used
terpene: (Terpene_synth or Terpene_synth_C or phytoene_synt or Lycopene_cycl or terpene_cyclase or NapT7 or fung_ggpps or fung_ggpps2 or trichodiene_synth or TRI5)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
MIBiG comparison
KnownClusterBlast
Pfam domains
TIGRFAM domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | terpene | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000647.1 |  | 0.33 | Terpene | carotenoid | Rhodobacter sphaeroides
BGC0000758.1 |  | 0.27 | Saccharide | capsular polysaccharide | Staphylococcus aureus
BGC0000648.1 |  | 0.19 | Terpene | carotenoid | Myxococcus xanthus
BGC0000656.1 |  | 0.19 | Terpene | zeaxanthin | Xanthobacter autotrophicus Py2
BGC0001579.1 |  | 0.17 | RiPP | duramycin | Streptomyces cinnamoneus
BGC0000563.1 |  | 0.17 | RiPP | venezuelin | Streptomyces venezuelae ATCC 10712
BGC0000616.1 |  | 0.17 | RiPP | amylocyclicin | Bacillus velezensis FZB42
BGC0000554.1 |  | 0.16 | RiPP | SRO15-3108 | Streptomyces filamentosus NRRL 15998
BGC0000640.1 |  | 0.16 | Terpene | carotenoid | Enterobacteriaceae bacterium DC404
BGC0000521.1 |  | 0.16 | RiPP | lacticin 481 | Lactococcus lactis subsp. lactis

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000647.1 |  | 0.66 | Terpene | carotenoid | Rhodobacter sphaeroides
BGC0000758.1 |  | 0.61 | Saccharide | capsular polysaccharide | Staphylococcus aureus
BGC0000648.1 |  | 0.51 | Terpene | carotenoid | Myxococcus xanthus
BGC0000656.1 |  | 0.51 | Terpene | zeaxanthin | Xanthobacter autotrophicus Py2
BGC0001579.1 |  | 0.49 | RiPP | duramycin | Streptomyces cinnamoneus
BGC0000563.1 |  | 0.48 | RiPP | venezuelin | Streptomyces venezuelae ATCC 10712
BGC0000616.1 |  | 0.48 | RiPP | amylocyclicin | Bacillus velezensis FZB42
BGC0000554.1 |  | 0.47 | RiPP | SRO15-3108 | Streptomyces filamentosus NRRL 15998
BGC0000640.1 |  | 0.47 | Terpene | carotenoid | Enterobacteriaceae bacterium DC404
BGC0000521.1 |  | 0.47 | RiPP | lacticin 481 | Lactococcus lactis subsp. lactis

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.

No matches found.

Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
NZ_CP023011.2 - Region 3 - lanthipeptide-class-ii
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 795,732 - 818,635 nt. (total: 22,904 nt) Show pHMM detection rules used
lanthipeptide-class-ii: cds(LANC_like and DUF4135)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
MIBiG comparison
KnownClusterBlast
Lanthipeptides
Pfam domains
TIGRFAM domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | lanthipeptide-class-ii | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001579.1 |  | 0.31 | RiPP | duramycin | Streptomyces cinnamoneus
BGC0000525.1 |  | 0.25 | RiPP | lichenicidin VK21 A1, lichenicidin VK21 A2 | Bacillus licheniformis
BGC0000554.1 |  | 0.25 | RiPP | SRO15-3108 | Streptomyces filamentosus NRRL 15998
BGC0000500.1 |  | 0.23 | RiPP | carnolysin A1, carnolysin A2 | Carnobacterium maltaromaticum
BGC0000504.1 |  | 0.23 | RiPP | cytolysin ClyLl, cytolysin ClyLs | Plasmid pAD1
BGC0000503.1 |  | 0.23 | RiPP | cinnamycin | Streptomyces cinnamoneus
BGC0000551.1 |  | 0.20 | RiPP | SapB | Streptomyces coelicolor A3(2)
BGC0000502.1 |  | 0.19 | RiPP | cerecidin, cerecidin A1, cerecidin A2, cerecidin A3, cerecidin A4, cerecidin A5, cerecidin A6, cerecidin A7 | Bacillus cereus
BGC0001407.1 |  | 0.18 | RiPP | bicereucin | Bacillus cereus SJ1
BGC0001391.1 |  | 0.18 | RiPP | thusin | Bacillus thuringiensis serovar rongseni

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001579.1 |  | 0.65 | RiPP | duramycin | Streptomyces cinnamoneus
BGC0000525.1 |  | 0.59 | RiPP | lichenicidin VK21 A1, lichenicidin VK21 A2 | Bacillus licheniformis
BGC0000554.1 |  | 0.59 | RiPP | SRO15-3108 | Streptomyces filamentosus NRRL 15998
BGC0000500.1 |  | 0.56 | RiPP | carnolysin A1, carnolysin A2 | Carnobacterium maltaromaticum
BGC0000504.1 |  | 0.56 | RiPP | cytolysin ClyLl, cytolysin ClyLs | Plasmid pAD1
BGC0000503.1 |  | 0.56 | RiPP | cinnamycin | Streptomyces cinnamoneus
BGC0000551.1 |  | 0.52 | RiPP | SapB | Streptomyces coelicolor A3(2)
BGC0000502.1 |  | 0.51 | RiPP | cerecidin, cerecidin A1, cerecidin A2, cerecidin A3, cerecidin A4, cerecidin A5, cerecidin A6, cerecidin A7 | Bacillus cereus
BGC0001407.1 |  | 0.50 | RiPP | bicereucin | Bacillus cereus SJ1
BGC0001391.1 |  | 0.49 | RiPP | thusin | Bacillus thuringiensis serovar rongseni

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.

No matches found.

Lanthipeptide predictions
Lists the possible core peptides for each biosynthetic enzyme, including the predicted class. Each core peptide shows the leader and core peptide sequences, separated by a dash.

#### Lanthipeptide(s) for ctg1_706 - Putative Class II

ctg1_707 leader / core peptide
  MAVGLLMKAGNVSEELAVLNNEHSLNASLDTICGT - MGDhaLGCGDhaFGCGDhaLDha Dha C C

#### Legend:

Dha: Didehydroalanine
Dhb: Didehydrobutyrine
Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
Lanthipeptides
Core peptide predictions
Lists the possible core peptides in the region. Each core peptide lists the number of lanthionine bridges, possible molecular weights, and the scores for cleavage site prediction and RODEO.

ctg1_707 - Class II
  Cleavage pHMM score: -5.10
  RODEO score: 0
  Monoisotopic mass: 1564.6 Da
  Molecular weight: 1565.8 Da
  Number of bridges: 4
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    1583.8 Da N = 1

NZ_CP023011.2 - Region 4 - cyclic-lactone-autoinducer
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 1,970,912 - 1,991,650 nt. (total: 20,739 nt) Show pHMM detection rules used
cyclic-lactone-autoinducer: (TIGR04223 or AgrB)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
MIBiG comparison
KnownClusterBlast
Pfam domains
TIGRFAM domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | cyclic-lactone-autoinducer | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001361.1 |  | 0.20 | Terpene | sodorifen | Serratia plymuthica 4Rx13
BGC0001120.1 |  | 0.19 | NRP, Polyketide | burkholderic acid | Burkholderia thailandensis E264
BGC0001291.1 |  | 0.17 | RiPP | enterocin NKR-5-3B | Enterococcus faecium
BGC0000883.1 |  | 0.15 | Other | arginomycin | Streptomyces arginensis
BGC0001664.1 |  | 0.15 | Terpene | merosterol | Scytonema sp. PCC 10023
BGC0001140.1 |  | 0.15 | Terpene | platensimycin, platencin | Streptomyces platensis
BGC0000666.1 |  | 0.15 | Terpene | xiamycin A | Streptomyces sp. SCSIO 02999
BGC0001156.1 |  | 0.15 | Terpene | platencin | Streptomyces platensis
BGC0000665.1 |  | 0.15 | Terpene, Alkaloid | xiamycin | Streptomyces sp. HKI0576
BGC0000765.1 |  | 0.15 | Saccharide | exopolysaccharide | Lactobacillus johnsonii

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001361.1 |  | 0.52 | Terpene | sodorifen | Serratia plymuthica 4Rx13
BGC0001120.1 |  | 0.51 | NRP, Polyketide | burkholderic acid | Burkholderia thailandensis E264
BGC0001291.1 |  | 0.49 | RiPP | enterocin NKR-5-3B | Enterococcus faecium
BGC0000883.1 |  | 0.46 | Other | arginomycin | Streptomyces arginensis
BGC0001664.1 |  | 0.46 | Terpene | merosterol | Scytonema sp. PCC 10023
BGC0001140.1 |  | 0.45 | Terpene | platensimycin, platencin | Streptomyces platensis
BGC0000666.1 |  | 0.45 | Terpene | xiamycin A | Streptomyces sp. SCSIO 02999
BGC0001156.1 |  | 0.45 | Terpene | platencin | Streptomyces platensis
BGC0000665.1 |  | 0.45 | Terpene, Alkaloid | xiamycin | Streptomyces sp. HKI0576
BGC0000765.1 |  | 0.44 | Saccharide | exopolysaccharide | Lactobacillus johnsonii

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.

No matches found.

Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
NZ_CP023011.2 - Region 5 - T3PKS
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 2,454,477 - 2,495,628 nt. (total: 41,152 nt) Show pHMM detection rules used
T3PKS: (Chal_sti_synt_C or Chal_sti_synt_N)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
NRPS/PKS domains
MIBiG comparison
KnownClusterBlast
Pfam domains
TIGRFAM domains
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
A glossary is available here.
Selected features only
Show module domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | T3PKS | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000286.1 |  | 0.23 | Polyketide | viguiepinol | Streptomyces sp. KO-3988
BGC0000867.1 |  | 0.18 | Other | polyhydroxyalkanoic acids | Ectothiorhodospira shaposhnikovii
BGC0000255.1 |  | 0.18 | Polyketide | pederin | Uncultured bacterium
BGC0000866.1 |  | 0.17 | Other | polyhydroxyalkanoate | Burkholderia sp. DSM 9242
BGC0001120.1 |  | 0.16 | NRP, Polyketide | burkholderic acid | Burkholderia thailandensis E264
BGC0001571.1 |  | 0.15 | Terpene | demethoxyviridin | Nodulisporium sp.
BGC0001080.1 |  | 0.14 | Other (Phenazine) | endophenazine A, endophenazine B | Streptomyces anulatus
BGC0001104.1 |  | 0.11 | NRP, Polyketide | myxovirescin A1 | Myxococcus xanthus DK 1622
BGC0001472.1 |  | 0.11 | RiPP | berninamycin A | Streptomyces bernensis
BGC0000934.1 |  | 0.11 | Other (Phenazine) | 5-acetyl-5,10-dihydrophenazine-1-carboxylic acid, 5-(2-hydroxyacetyl)-5,10-dihydrophenazine-1-carboxylic acid, endophenazine A1, endophenazine F, endophenazine G | Kitasatospora sp. HKI 714

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000286.1 |  | 0.56 | Polyketide | viguiepinol | Streptomyces sp. KO-3988
BGC0000867.1 |  | 0.49 | Other | polyhydroxyalkanoic acids | Ectothiorhodospira shaposhnikovii
BGC0000255.1 |  | 0.49 | Polyketide | pederin | Uncultured bacterium
BGC0000866.1 |  | 0.49 | Other | polyhydroxyalkanoate | Burkholderia sp. DSM 9242
BGC0001120.1 |  | 0.46 | NRP, Polyketide | burkholderic acid | Burkholderia thailandensis E264
BGC0001571.1 |  | 0.45 | Terpene | demethoxyviridin | Nodulisporium sp.
BGC0001080.1 |  | 0.44 | Other (Phenazine) | endophenazine A, endophenazine B | Streptomyces anulatus
BGC0001104.1 |  | 0.38 | NRP, Polyketide | myxovirescin A1 | Myxococcus xanthus DK 1622
BGC0001472.1 |  | 0.38 | RiPP | berninamycin A | Streptomyces bernensis
BGC0000934.1 |  | 0.37 | Other (Phenazine) | 5-acetyl-5,10-dihydrophenazine-1-carboxylic acid, 5-(2-hydroxyacetyl)-5,10-dihydrophenazine-1-carboxylic acid, endophenazine A1, endophenazine F, endophenazine G | Kitasatospora sp. HKI 714

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.

No matches found.

Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names