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Overview
5.1
5.2
5.3
5.4

### Identified secondary metabolite regions using strictness 'relaxed'

NZ_LXZX01000005 (original name was: NZ_LXZX01000005.1)

Region | Type | From | To | Most similar known cluster | Similarity
--- | --- | --- | --- | --- | ---
Region 5.1 | RiPP-like | 167,580 | 175,246 |
Region 5.2 | lanthipeptide-class-iv | 339,775 | 361,961 |
Region 5.3 | RiPP-like | 694,236 | 706,332 |
Region 5.4 | T3PKS | 1,302,155 | 1,343,330 | fogacin A / fogacin B / fogacin C | Polyketide | 5%

Region | Type | From | To | Most similar known cluster | Similarity
--- | --- | --- | --- | --- | ---
Region 5.1 | RiPP-like | 167,580 | 175,246 |
Region 5.2 | lanthipeptide-class-iv | 339,775 | 361,961 |
Region 5.3 | RiPP-like | 694,236 | 706,332 |
Region 5.4 | T3PKS | 1,302,155 | 1,343,330 | fogacin A / fogacin B / fogacin C | Polyketide | 5%

No secondary metabolite regions were found in these records:
  NZ_LXZX01000001 (original name was: NZ_LXZX01000001.1)
  NZ_LXZX01000002 (original name was: NZ_LXZX01000002.1)
  NZ_LXZX01000003 (original name was: NZ_LXZX01000003.1)
  NZ_LXZX01000004 (original name was: NZ_LXZX01000004.1)
  NZ_LXZX01000006 (original name was: NZ_LXZX01000006.1)
  NZ_LXZX01000007 (original name was: NZ_LXZX01000007.1)

Compact view
c00005_NZ_LXZX.. - Region 1 - RiPP-like
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 167,580 - 175,246 nt. (total: 7,667 nt) Show pHMM detection rules used
RiPP-like: (strepbact or Antimicrobial14 or Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or Lactococcin or Antimicrobial17 or Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or TIGR03975 or DUF692 or TIGR01193)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
MIBiG comparison
KnownClusterBlast
Pfam domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | RiPP-like | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000563.1 |  | 0.15 | RiPP | venezuelin | Streptomyces venezuelae ATCC 10712
BGC0000519.1 |  | 0.15 | RiPP | labyrinthopeptin A2, labyrinthopeptin A1, labyrinthopeptin A3 | Actinomadura namibiensis
BGC0000554.1 |  | 0.15 | RiPP | SRO15-3108 | Streptomyces filamentosus NRRL 15998
BGC0000513.1 |  | 0.15 | RiPP | Ery-9, Ery-6, Ery-8, Ery-7, Ery-5, Ery-4, Ery-3 | Saccharopolyspora erythraea NRRL 2338
BGC0000584.1 |  | 0.14 | RiPP | colicin V | Escherichia coli
BGC0001928.1 |  | 0.14 | Other | (2R,3S,4S)-5-fluoro-2,3,4-trihydroxypentanoic acid | Streptomyces sp. MA37
BGC0000294.1 |  | 0.14 | NRP | acinetobactin | Acinetobacter baumannii
BGC0001484.1 |  | 0.13 | Other | 2'-chloropentostatin, 2'-amino-2'-deoxyadenosine | Actinomadura sp. ATCC 39365
BGC0000802.1 |  | 0.13 | Saccharide | succinoglycan | Sinorhizobium meliloti
BGC0000703.1 |  | 0.13 | Saccharide | kanamycin | Streptomyces kanamyceticus

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000563.1 |  | 0.46 | RiPP | venezuelin | Streptomyces venezuelae ATCC 10712
BGC0000519.1 |  | 0.45 | RiPP | labyrinthopeptin A2, labyrinthopeptin A1, labyrinthopeptin A3 | Actinomadura namibiensis
BGC0000554.1 |  | 0.45 | RiPP | SRO15-3108 | Streptomyces filamentosus NRRL 15998
BGC0000513.1 |  | 0.45 | RiPP | Ery-9, Ery-6, Ery-8, Ery-7, Ery-5, Ery-4, Ery-3 | Saccharopolyspora erythraea NRRL 2338
BGC0000584.1 |  | 0.44 | RiPP | colicin V | Escherichia coli
BGC0001928.1 |  | 0.44 | Other | (2R,3S,4S)-5-fluoro-2,3,4-trihydroxypentanoic acid | Streptomyces sp. MA37
BGC0000294.1 |  | 0.44 | NRP | acinetobactin | Acinetobacter baumannii
BGC0001484.1 |  | 0.42 | Other | 2'-chloropentostatin, 2'-amino-2'-deoxyadenosine | Actinomadura sp. ATCC 39365
BGC0000802.1 |  | 0.42 | Saccharide | succinoglycan | Sinorhizobium meliloti
BGC0000703.1 |  | 0.42 | Saccharide | kanamycin | Streptomyces kanamyceticus

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.

No matches found.

Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
c00005_NZ_LXZX.. - Region 2 - lanthipeptide-class-iv
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 339,775 - 361,961 nt. (total: 22,187 nt) Show pHMM detection rules used
lanthipeptide-class-iv: (cds(LANC_like and Pkinase) and not micKC)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
MIBiG comparison
KnownClusterBlast
Lanthipeptides
Pfam domains
TIGRFAM domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | lanthipeptide-class-iv | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000551.1 |  | 0.21 | RiPP | SapB | Streptomyces coelicolor A3(2)
BGC0000519.1 |  | 0.21 | RiPP | labyrinthopeptin A2, labyrinthopeptin A1, labyrinthopeptin A3 | Actinomadura namibiensis
BGC0000494.1 |  | 0.17 | RiPP | uberolysin | Streptococcus uberis
BGC0001639.1 |  | 0.16 | RiPP | klebsidin | Klebsiella pneumoniae
BGC0000539.1 |  | 0.16 | RiPP | nukacin ISK-1 | Staphylococcus warneri
BGC0000486.1 |  | 0.16 | RiPP | butyrivibriocin AR10 | Butyrivibrio fibrisolvens
BGC0000553.1 |  | 0.15 | RiPP | SRO15-2212 | Streptomyces filamentosus NRRL 15998
BGC0000521.1 |  | 0.15 | RiPP | lacticin 481 | Lactococcus lactis subsp. lactis
BGC0000513.1 |  | 0.15 | RiPP | Ery-9, Ery-6, Ery-8, Ery-7, Ery-5, Ery-4, Ery-3 | Saccharopolyspora erythraea NRRL 2338
BGC0000626.1 |  | 0.15 | RiPP | thuricin | Bacillus thuringiensis

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000551.1 |  | 0.53 | RiPP | SapB | Streptomyces coelicolor A3(2)
BGC0000519.1 |  | 0.53 | RiPP | labyrinthopeptin A2, labyrinthopeptin A1, labyrinthopeptin A3 | Actinomadura namibiensis
BGC0000494.1 |  | 0.49 | RiPP | uberolysin | Streptococcus uberis
BGC0001639.1 |  | 0.47 | RiPP | klebsidin | Klebsiella pneumoniae
BGC0000539.1 |  | 0.46 | RiPP | nukacin ISK-1 | Staphylococcus warneri
BGC0000486.1 |  | 0.46 | RiPP | butyrivibriocin AR10 | Butyrivibrio fibrisolvens
BGC0000553.1 |  | 0.46 | RiPP | SRO15-2212 | Streptomyces filamentosus NRRL 15998
BGC0000521.1 |  | 0.46 | RiPP | lacticin 481 | Lactococcus lactis subsp. lactis
BGC0000513.1 |  | 0.46 | RiPP | Ery-9, Ery-6, Ery-8, Ery-7, Ery-5, Ery-4, Ery-3 | Saccharopolyspora erythraea NRRL 2338
BGC0000626.1 |  | 0.45 | RiPP | thuricin | Bacillus thuringiensis

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.

No matches found.

Lanthipeptide predictions
Lists the possible core peptides for each biosynthetic enzyme, including the predicted class. Each core peptide shows the leader and core peptide sequences, separated by a dash.
Lanthipeptides - No core peptides found.
Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
Lanthipeptides
Core peptide predictions
Lists the possible core peptides in the region. Each core peptide lists the number of lanthionine bridges, possible molecular weights, and the scores for cleavage site prediction and RODEO.
No core peptides found.
c00005_NZ_LXZX.. - Region 3 - RiPP-like
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 694,236 - 706,332 nt. (total: 12,097 nt) Show pHMM detection rules used
RiPP-like: (strepbact or Antimicrobial14 or Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or Lactococcin or Antimicrobial17 or Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or TIGR03975 or DUF692 or TIGR01193)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
MIBiG comparison
KnownClusterBlast
Pfam domains
TIGRFAM domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | RiPP-like | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000617.1 |  | 0.20 | RiPP | coagulin | Bacillus coagulans
BGC0000558.1 |  | 0.16 | RiPP | sublancin 168 | Bacillus subtilis subsp. subtilis str. 168
BGC0000619.1 |  | 0.15 | RiPP | gassericin T | Lactobacillus gasseri
BGC0001602.1 |  | 0.15 | RiPP | gassericin-T | Lactobacillus gasseri
BGC0001388.1 |  | 0.15 | RiPP | gassericin E | Lactobacillus gasseri
BGC0000294.1 |  | 0.15 | NRP | acinetobactin | Acinetobacter baumannii
BGC0000584.1 |  | 0.14 | RiPP | colicin V | Escherichia coli
BGC0000624.1 |  | 0.14 | RiPP | salivaricin CRL1328 α peptide, salivaricin CRL1328 β peptide | Lactobacillus salivarius
BGC0000586.1 |  | 0.14 | RiPP | microcin E492 | Klebsiella pneumoniae RYC492
BGC0000587.1 |  | 0.14 | RiPP | microcin H47 | Escherichia coli

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000617.1 |  | 0.53 | RiPP | coagulin | Bacillus coagulans
BGC0000558.1 |  | 0.46 | RiPP | sublancin 168 | Bacillus subtilis subsp. subtilis str. 168
BGC0000619.1 |  | 0.45 | RiPP | gassericin T | Lactobacillus gasseri
BGC0001602.1 |  | 0.45 | RiPP | gassericin-T | Lactobacillus gasseri
BGC0001388.1 |  | 0.45 | RiPP | gassericin E | Lactobacillus gasseri
BGC0000294.1 |  | 0.45 | NRP | acinetobactin | Acinetobacter baumannii
BGC0000584.1 |  | 0.44 | RiPP | colicin V | Escherichia coli
BGC0000624.1 |  | 0.43 | RiPP | salivaricin CRL1328 α peptide, salivaricin CRL1328 β peptide | Lactobacillus salivarius
BGC0000586.1 |  | 0.43 | RiPP | microcin E492 | Klebsiella pneumoniae RYC492
BGC0000587.1 |  | 0.43 | RiPP | microcin H47 | Escherichia coli

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.

No matches found.

Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
c00005_NZ_LXZX.. - Region 4 - T3PKS
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 1,302,155 - 1,343,330 nt. (total: 41,176 nt) Show pHMM detection rules used
T3PKS: (Chal_sti_synt_C or Chal_sti_synt_N)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
NRPS/PKS domains
MIBiG comparison
KnownClusterBlast
Pfam domains
TIGRFAM domains
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
A glossary is available here.
Selected features only
Show module domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | T3PKS | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000803.1 |  | 0.26 | Saccharide | GG exopolysaccharide | Lactobacillus rhamnosus GG
BGC0000286.1 |  | 0.23 | Polyketide | viguiepinol | Streptomyces sp. KO-3988
BGC0001412.1 |  | 0.23 | Saccharide | polysaccharide C | Bacteroides fragilis
BGC0000214.1 |  | 0.19 | Polyketide | cosmomycin B | Streptomyces olindensis
BGC0000781.1 |  | 0.17 | Saccharide | O-antigen | Pseudomonas aeruginosa
BGC0000813.1 |  | 0.16 | Alkaloid | K-252a | Nonomuraea longicatena
BGC0000827.1 |  | 0.16 | Alkaloid | staurosporine | Salinispora arenicola CNS-205
BGC0001387.1 |  | 0.16 | Other | nucleocidin | Streptomyces calvus
BGC0000792.1 |  | 0.16 | Saccharide | polysaccharide | Enterococcus faecalis OG1RF
BGC0000825.1 |  | 0.16 | Alkaloid | staurosporine | Streptomyces sp. TP-A0274

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000803.1 |  | 0.60 | Saccharide | GG exopolysaccharide | Lactobacillus rhamnosus GG
BGC0000286.1 |  | 0.56 | Polyketide | viguiepinol | Streptomyces sp. KO-3988
BGC0001412.1 |  | 0.56 | Saccharide | polysaccharide C | Bacteroides fragilis
BGC0000214.1 |  | 0.51 | Polyketide | cosmomycin B | Streptomyces olindensis
BGC0000781.1 |  | 0.48 | Saccharide | O-antigen | Pseudomonas aeruginosa
BGC0000813.1 |  | 0.47 | Alkaloid | K-252a | Nonomuraea longicatena
BGC0000827.1 |  | 0.47 | Alkaloid | staurosporine | Salinispora arenicola CNS-205
BGC0001387.1 |  | 0.47 | Other | nucleocidin | Streptomyces calvus
BGC0000792.1 |  | 0.47 | Saccharide | polysaccharide | Enterococcus faecalis OG1RF
BGC0000825.1 |  | 0.47 | Alkaloid | staurosporine | Streptomyces sp. TP-A0274

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.
Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names