GCF_900475975.1_46931_F01_genomic - 5 region(s)

Identified secondary metabolite regions using strictness 'relaxed'

NZ_LS483436.1

Region	Type	From	To
Region 1	RaS-RiPP	133,836	157,098
Region 2	T3PKS	198,192	239,364
Region 3	RiPP-like	242,254	251,034
Region 4	RiPP-like	554,766	575,231
Region 5	NRPS	1,627,786	1,675,919

NZ_LS483436.1 - Region 1 - RaS-RiPP

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Location: 133,836 - 157,098 nt. (total: 23,263 nt) Show pHMM detection rules used

RaS-RiPP: (PF04055 and TIGR01716)

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core biosynthetic genes

additional biosynthetic genes

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Gene details

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MIBiG comparison

KnownClusterBlast

Pfam domains

TIGRFAM domains

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001209.1	0.33	RiPP	streptide	Streptococcus thermophilus LMD-9
BGC0001929.1	0.25	RiPP	WGK	Streptococcus ferus
BGC0000602.1	0.21	RiPP	subtilosin A	Bacillus subtilis subsp. spizizenii ATCC 6633
BGC0001521.1	0.16	NRP	auriculamide	Herpetosiphon aurantiacus DSM 785
BGC0000490.1	0.16	RiPP	garvicin ML	Lactococcus garvieae DCC43
BGC0001222.1	0.16	RiPP	acidocin B	Lactobacillus acidophilus
BGC0000491.1	0.16	RiPP	gassericin A	Lactobacillus gasseri
BGC0001743.1	0.15	RiPP	plantaricyclin	Lactobacillus plantarum
BGC0000497.1	0.15	RiPP	BHT-Aα, BHT-Aβ	Streptococcus ratti
BGC0001540.1	0.14	Other	CC-1065	Streptomyces zelensis

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001209.1	0.67	RiPP	streptide	Streptococcus thermophilus LMD-9
BGC0001929.1	0.59	RiPP	WGK	Streptococcus ferus
BGC0000602.1	0.54	RiPP	subtilosin A	Bacillus subtilis subsp. spizizenii ATCC 6633
BGC0001521.1	0.47	NRP	auriculamide	Herpetosiphon aurantiacus DSM 785
BGC0000490.1	0.46	RiPP	garvicin ML	Lactococcus garvieae DCC43
BGC0001222.1	0.46	RiPP	acidocin B	Lactobacillus acidophilus
BGC0000491.1	0.46	RiPP	gassericin A	Lactobacillus gasseri
BGC0001743.1	0.45	RiPP	plantaricyclin	Lactobacillus plantarum
BGC0000497.1	0.45	RiPP	BHT-Aα, BHT-Aβ	Streptococcus ratti
BGC0001540.1	0.44	Other	CC-1065	Streptomyces zelensis

Similar known gene clusters

No matches found.

Detailed Pfam domain annotation

Selected features only

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Detailed TIGRFAM domain annotation

Selected features only

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NZ_LS483436.1 - Region 2 - T3PKS

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Location: 198,192 - 239,364 nt. (total: 41,173 nt) Show pHMM detection rules used

T3PKS: (Chal_sti_synt_C or Chal_sti_synt_N)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

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Gene details

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MIBiG comparison

KnownClusterBlast

Pfam domains

TIGRFAM domains

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000205.1	0.16	Polyketide	bryostatin	Candidatus Endobugula sertula
BGC0000286.1	0.15	Polyketide	viguiepinol	Streptomyces sp. KO-3988
BGC0000255.1	0.15	Polyketide	pederin	Uncultured bacterium
BGC0001080.1	0.12	Other (Phenazine)	endophenazine A, endophenazine B	Streptomyces anulatus
BGC0000934.1	0.11	Other (Phenazine)	5-acetyl-5,10-dihydrophenazine-1-carboxylic acid, 5-(2-hydroxyacetyl)-5,10-dihydrophenazine-1-carboxylic acid, endophenazine A1, endophenazine F, endophenazine G	Kitasatospora sp. HKI 714
BGC0000643.1	0.10	Terpene	carotenoid	Brevundimonas vesicularis
BGC0001078.1	0.10	Terpene, Polyketide	furaquinocin B	Streptomyces sp. KO-3988
BGC0000679.1	0.10	Terpene	diazepinomicin	Micromonospora sp. M42
BGC0001076.1	0.09	Other (Nucleoside)	liposidomycin B, liposidomycin A, liposidomycin C, liposidomycin Z, liposidomycin H, liposidomycin G, liposidomycin L, liposidomycin M, liposidomycin K, liposidomycin N	Streptomyces sp. SN-1061M
BGC0000652.1	0.09	Terpene	napyradiomycin	Streptomyces sp. CNQ525

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000205.1	0.46	Polyketide	bryostatin	Candidatus Endobugula sertula
BGC0000286.1	0.45	Polyketide	viguiepinol	Streptomyces sp. KO-3988
BGC0000255.1	0.45	Polyketide	pederin	Uncultured bacterium
BGC0001080.1	0.39	Other (Phenazine)	endophenazine A, endophenazine B	Streptomyces anulatus
BGC0000934.1	0.38	Other (Phenazine)	5-acetyl-5,10-dihydrophenazine-1-carboxylic acid, 5-(2-hydroxyacetyl)-5,10-dihydrophenazine-1-carboxylic acid, endophenazine A1, endophenazine F, endophenazine G	Kitasatospora sp. HKI 714
BGC0000643.1	0.36	Terpene	carotenoid	Brevundimonas vesicularis
BGC0001078.1	0.35	Terpene, Polyketide	furaquinocin B	Streptomyces sp. KO-3988
BGC0000679.1	0.35	Terpene	diazepinomicin	Micromonospora sp. M42
BGC0001076.1	0.34	Other (Nucleoside)	liposidomycin B, liposidomycin A, liposidomycin C, liposidomycin Z, liposidomycin H, liposidomycin G, liposidomycin L, liposidomycin M, liposidomycin K, liposidomycin N	Streptomyces sp. SN-1061M
BGC0000652.1	0.34	Terpene	napyradiomycin	Streptomyces sp. CNQ525

Similar known gene clusters

No matches found.

Detailed Pfam domain annotation

Selected features only

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Detailed TIGRFAM domain annotation

Selected features only

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NZ_LS483436.1 - Region 3 - RiPP-like

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Location: 242,254 - 251,034 nt. (total: 8,781 nt) Show pHMM detection rules used

RiPP-like: (strepbact or Antimicrobial14 or Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or Lactococcin or Antimicrobial17 or Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or TIGR03975 or DUF692 or TIGR01193)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

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Gene details

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MIBiG comparison

KnownClusterBlast

Pfam domains

TIGRFAM domains

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001891.1	0.16	Other	closthioamide	Ruminiclostridium cellulolyticum H10
BGC0001639.1	0.16	RiPP	klebsidin	Klebsiella pneumoniae
BGC0000554.1	0.15	RiPP	SRO15-3108	Streptomyces filamentosus NRRL 15998
BGC0000294.1	0.15	NRP	acinetobactin	Acinetobacter baumannii
BGC0001765.1	0.14	Saccharide	salecan	Agrobacterium tumefaciens
BGC0001120.1	0.14	NRP, Polyketide	burkholderic acid	Burkholderia thailandensis E264
BGC0000916.1	0.14	Other	molybdenum cofactor	Staphylococcus carnosus
BGC0000548.1	0.14	RiPP	salivaricin A	Streptococcus salivarius
BGC0002009.1	0.14	Polyketide	kanglemycin A, kanglemycin V1, kanglemycin V2	Amycolatopsis vancoresmycina
BGC0000802.1	0.14	Saccharide	succinoglycan	Sinorhizobium meliloti

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001891.1	0.46	Other	closthioamide	Ruminiclostridium cellulolyticum H10
BGC0001639.1	0.46	RiPP	klebsidin	Klebsiella pneumoniae
BGC0000554.1	0.46	RiPP	SRO15-3108	Streptomyces filamentosus NRRL 15998
BGC0000294.1	0.45	NRP	acinetobactin	Acinetobacter baumannii
BGC0001765.1	0.44	Saccharide	salecan	Agrobacterium tumefaciens
BGC0001120.1	0.44	NRP, Polyketide	burkholderic acid	Burkholderia thailandensis E264
BGC0000916.1	0.44	Other	molybdenum cofactor	Staphylococcus carnosus
BGC0000548.1	0.44	RiPP	salivaricin A	Streptococcus salivarius
BGC0002009.1	0.43	Polyketide	kanglemycin A, kanglemycin V1, kanglemycin V2	Amycolatopsis vancoresmycina
BGC0000802.1	0.43	Saccharide	succinoglycan	Sinorhizobium meliloti

Similar known gene clusters

No matches found.

Detailed Pfam domain annotation

Selected features only

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Detailed TIGRFAM domain annotation

Selected features only

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NZ_LS483436.1 - Region 4 - RiPP-like

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Location: 554,766 - 575,231 nt. (total: 20,466 nt) Show pHMM detection rules used

RiPP-like: (strepbact or Antimicrobial14 or Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or Lactococcin or Antimicrobial17 or Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or TIGR03975 or DUF692 or TIGR01193)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

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Gene details

Select a gene to view the details available for it

MIBiG comparison

KnownClusterBlast

Pfam domains

TIGRFAM domains

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000619.1	0.41	RiPP	gassericin T	Lactobacillus gasseri
BGC0001388.1	0.41	RiPP	gassericin E	Lactobacillus gasseri
BGC0001602.1	0.41	RiPP	gassericin-T	Lactobacillus gasseri
BGC0000624.1	0.35	RiPP	salivaricin CRL1328 α peptide, salivaricin CRL1328 β peptide	Lactobacillus salivarius
BGC0000617.1	0.31	RiPP	coagulin	Bacillus coagulans
BGC0001229.1	0.18	RiPP	SBI-06990 A1, SBI-06989 A2	Streptomyces bingchenggensis BCW-1
BGC0000558.1	0.16	RiPP	sublancin 168	Bacillus subtilis subsp. subtilis str. 168
BGC0001862.1	0.16	RiPP	geocillicin	Aeribacillus pallidus
BGC0001930.1	0.16	RiPP	pallidocin	Aeribacillus pallidus
BGC0001861.1	0.15	RiPP	bacillicin BAG2O	Bacillus cereus BAG2O-1

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000619.1	0.72	RiPP	gassericin T	Lactobacillus gasseri
BGC0001388.1	0.72	RiPP	gassericin E	Lactobacillus gasseri
BGC0001602.1	0.72	RiPP	gassericin-T	Lactobacillus gasseri
BGC0000624.1	0.68	RiPP	salivaricin CRL1328 α peptide, salivaricin CRL1328 β peptide	Lactobacillus salivarius
BGC0000617.1	0.65	RiPP	coagulin	Bacillus coagulans
BGC0001229.1	0.49	RiPP	SBI-06990 A1, SBI-06989 A2	Streptomyces bingchenggensis BCW-1
BGC0000558.1	0.47	RiPP	sublancin 168	Bacillus subtilis subsp. subtilis str. 168
BGC0001862.1	0.46	RiPP	geocillicin	Aeribacillus pallidus
BGC0001930.1	0.46	RiPP	pallidocin	Aeribacillus pallidus
BGC0001861.1	0.46	RiPP	bacillicin BAG2O	Bacillus cereus BAG2O-1

Similar known gene clusters

No matches found.

Detailed Pfam domain annotation

Selected features only

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Detailed TIGRFAM domain annotation

Selected features only

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NZ_LS483436.1 - Region 5 - NRPS

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Location: 1,627,786 - 1,675,919 nt. (total: 48,134 nt) Show pHMM detection rules used

NRPS: cds(Condensation and (AMP-binding or A-OX))

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

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Gene details

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NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

Pfam domains

TIGRFAM domains

Detailed domain annotation

Selected features only

Show module domains

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001343.1	0.27	Polyketide	aurachin A, aurachin D	Stigmatella aurantiaca Sg a15
BGC0000426.1	0.26	NRP	sevadicin	Paenibacillus larvae
BGC0000410.1	0.26	NRP	pseudomonine	Pseudomonas fluorescens
BGC0001251.1	0.26	NRP	epichloenin A	Epichloe festucae
BGC0001250.1	0.26	NRP	epichloenin A	Epichloe festucae
BGC0001609.1	0.24	NRP	gliovirin	Trichoderma virens Gv29-8
BGC0001687.1	0.24	Other	N-tetradecanoyl tyrosine	uncultured bacterium CSL12
BGC0000460.1	0.23	NRP	vulnibactin	Vibrio vulnificus CMCP6
BGC0000949.1	0.22	NRP	A-500359 A, A-500359 B	Streptomyces griseus
BGC0000427.1	0.22	NRP	shinorine, 4-deoxygadusol, mycosporine glycine	Trichormus variabilis ATCC 29413

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001343.1	0.60	Polyketide	aurachin A, aurachin D	Stigmatella aurantiaca Sg a15
BGC0000426.1	0.60	NRP	sevadicin	Paenibacillus larvae
BGC0000410.1	0.60	NRP	pseudomonine	Pseudomonas fluorescens
BGC0001251.1	0.59	NRP	epichloenin A	Epichloe festucae
BGC0001250.1	0.59	NRP	epichloenin A	Epichloe festucae
BGC0001609.1	0.58	NRP	gliovirin	Trichoderma virens Gv29-8
BGC0001687.1	0.58	Other	N-tetradecanoyl tyrosine	uncultured bacterium CSL12
BGC0000460.1	0.56	NRP	vulnibactin	Vibrio vulnificus CMCP6
BGC0000949.1	0.55	NRP	A-500359 A, A-500359 B	Streptomyces griseus
BGC0000427.1	0.55	NRP	shinorine, 4-deoxygadusol, mycosporine glycine	Trichormus variabilis ATCC 29413

Similar known gene clusters

No matches found.

Module view

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Detailed Pfam domain annotation

Selected features only

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Detailed TIGRFAM domain annotation

Selected features only

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NRPS/PKS products

NRPS/PKS monomers

Predicted core structure(s)

For candidate cluster 5, location 1627785 - 1675919:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (X) + (ser)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS monomer predictions

ctg1_1563

Search NORINE for peptide: strict or relaxed

AMP-binding (460..858): ser

NRPSPredictor2: ser

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic
Large clusters prediction:: ser, thr, dhpg, hpg
Small clusters prediction:: ser
Single AA prediction:: ser

Stachelhaus prediction details:

Stachelhaus sequence:: DVWHVSLIDK
Nearest Stachelhaus code:: ser
Stachelhaus code match:: 100% (strong)

ctg1_1565

Search NORINE for peptide: strict or relaxed

AMP-binding (466..857): X

NRPSPredictor2: hydrophobic-aliphatic

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic
Large clusters prediction:: N/A
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: DGfTsAliSK
Nearest Stachelhaus code:: phe
Stachelhaus code match:: 60% (weak)