LOCUS       NZ_LS483436.1           8781 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  NZ_LS483436.1 Streptococcus intermedius strain NCTC11324 chromosome
            1, complete sequence.
ACCESSION   NZ_LS483436
VERSION     NZ_LS483436.1
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 6.1.1
            Run date     :: 2024-03-14 13:19:23
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 242253
            Orig. end    :: 251034
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     CDS             1..936
                     /locus_tag="ctg1_223"
                     /transl_table=11
                     /translation="MVSTQTQIAGFSFDNCLMNAAGVACMTIEELEKVKQSAAGTFVTK
                     TATLQARAGNPEPRYQDVPLGSINSMGLPNHGLDYYLDYLLDLQKIEPNRTFFLSLVGL
                     SPEETHTLLKKVQDSDFKGLTELNLSCPNVPGKPQIAYDFEMTDKILSDVFDYFTKPLG
                     IKLPPYFDIVHFDQAAAIFNKFPLCFVNCVNSIGNGLYVEDESVVIRPKNGFGGIGGAY
                     IKPTALANVHAFYQRLNPTIQIIGTGGVLTGRDAFEHILCGASMVQVGTTLHKEGVESF
                     ERITEELKVMMAEKGYESIEDFRGKLNHLN"
     protocluster    1..8781
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[246541:246904](+)"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193)"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      4289..4651
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193)"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
     cand_cluster    1..8781
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193)"
                     /kind="single"
                     /product="RiPP-like"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..8781
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="RiPP-like"
                     /region_number="3"
                     /rules="(strepbact or Antimicrobial14 or Bacteriocin_IId or
                     BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or
                     Lactococcin or Antimicrobial17 or Lactococcin_972 or
                     Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or
                     TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or
                     TIGR03975 or DUF692 or TIGR01193)"
                     /tool="antismash"
     PFAM_domain     13..876
                     /aSDomain="DHO_dh"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF01180.23"
                     /description="Dihydroorotate dehydrogenase"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_223_0070"
                     /evalue="6.60E-79"
                     /label="ctg1_223"
                     /locus_tag="ctg1_223"
                     /protein_end="292"
                     /protein_start="4"
                     /score="265.3"
                     /tool="antismash"
                     /translation="QTQIAGFSFDNCLMNAAGVACMTIEELEKVKQSAAGTFVTKTATL
                     QARAGNPEPRYQDVPLGSINSMGLPNHGLDYYLDYLLDLQKIEPNRTFFLSLVGLSPEE
                     THTLLKKVQDSDFKGLTELNLSCPNVPGKPQIAYDFEMTDKILSDVFDYFTKPLGIKLP
                     PYFDIVHFDQAAAIFNKFPLCFVNCVNSIGNGLYVEDESVVIRPKNGFGGIGGAYIKPT
                     ALANVHAFYQRLNPTIQIIGTGGVLTGRDAFEHILCGASMVQVGTTLHKEGVESFERIT
                     EELKVMM"
     aSDomain        13..915
                     /aSDomain="TIGR01037"
                     /aSTool="tigrfam"
                     /description="pyrD_sub1_fam: dihydroorotate dehydrogenase
                     family protein"
                     /detection="hmmscan"
                     /domain_id="TIGRFam_ctg1_223_0020"
                     /evalue="6.80E-53"
                     /identifier="TIGR01037"
                     /label="ctg1_223"
                     /locus_tag="ctg1_223"
                     /protein_end="305"
                     /protein_start="4"
                     /score="177.6"
                     /tool="antismash"
                     /translation="QTQIAGFSFDNCLMNAAGVACMTIEELEKVKQSAAGTFVTKTATL
                     QARAGNPEPRYQDVPLGSINSMGLPNHGLDYYLDYLLDLQKIEPNRTFFLSLVGLSPEE
                     THTLLKKVQDSDFKGLTELNLSCPNVPGKPQIAYDFEMTDKILSDVFDYFTKPLGIKLP
                     PYFDIVHFDQAAAIFNKFPLCFVNCVNSIGNGLYVEDESVVIRPKNGFGGIGGAYIKPT
                     ALANVHAFYQRLNPTIQIIGTGGVLTGRDAFEHILCGASMVQVGTTLHKEGVESFERIT
                     EELKVMMAEKGYESIEDFRG"
     CDS             1054..1989
                     /locus_tag="ctg1_224"
                     /transl_table=11
                     /translation="MSEIYLAGGCFWGLEEYFSRIKGVTDTTVGYANGQVESTNYQLIH
                     QTDHAETVQVTYDDNLVTLREILLYYFRVIDPLSINKQGNDIGRQYRTGIYYTNDTDAP
                     IIAEVTKEQEEQFGQKIAVEVEPLRHYVLAEEYHQDYLKKNPSGYCHINVNDAYQPLVD
                     PSQYEKPSELTLKETLSEEAYQVTQHAATERPFQNEYFATFEEGIYVDVTTGEPLFFAG
                     DKFDSGCGWPSFTRPIAKDVIKYYQDKSHGMERIEVRSRSGNAHLGHVFTDGPQEQGGL
                     RYCINSAALRFIKKEEMEETGYGYLLSYMR"
     aSDomain        1060..1503
                     /aSDomain="TIGR00401"
                     /aSTool="tigrfam"
                     /description="msrA: peptide-methionine (S)-S-oxide
                     reductase"
                     /detection="hmmscan"
                     /domain_id="TIGRFam_ctg1_224_0022"
                     /evalue="4.20E-50"
                     /identifier="TIGR00401"
                     /label="ctg1_224"
                     /locus_tag="ctg1_224"
                     /protein_end="150"
                     /protein_start="2"
                     /score="168.1"
                     /tool="antismash"
                     /translation="EIYLAGGCFWGLEEYFSRIKGVTDTTVGYANGQVESTNYQLIHQT
                     DHAETVQVTYDDNLVTLREILLYYFRVIDPLSINKQGNDIGRQYRTGIYYTNDTDAPII
                     AEVTKEQEEQFGQKIAVEVEPLRHYVLAEEYHQDYLKKNPSGYC"
     PFAM_domain     1060..1506
                     /aSDomain="PMSR"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF01625.23"
                     /description="Peptide methionine sulfoxide reductase"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_224_0071"
                     /evalue="8.10E-57"
                     /label="ctg1_224"
                     /locus_tag="ctg1_224"
                     /protein_end="151"
                     /protein_start="2"
                     /score="191.8"
                     /tool="antismash"
                     /translation="EIYLAGGCFWGLEEYFSRIKGVTDTTVGYANGQVESTNYQLIHQT
                     DHAETVQVTYDDNLVTLREILLYYFRVIDPLSINKQGNDIGRQYRTGIYYTNDTDAPII
                     AEVTKEQEEQFGQKIAVEVEPLRHYVLAEEYHQDYLKKNPSGYCH"
     aSDomain        1561..1962
                     /aSDomain="TIGR00357"
                     /aSTool="tigrfam"
                     /description="TIGR00357: methionine-R-sulfoxide reductase"
                     /detection="hmmscan"
                     /domain_id="TIGRFam_ctg1_224_0021"
                     /evalue="2.60E-62"
                     /identifier="TIGR00357"
                     /label="ctg1_224"
                     /locus_tag="ctg1_224"
                     /protein_end="303"
                     /protein_start="169"
                     /score="206.7"
                     /tool="antismash"
                     /translation="PSELTLKETLSEEAYQVTQHAATERPFQNEYFATFEEGIYVDVTT
                     GEPLFFAGDKFDSGCGWPSFTRPIAKDVIKYYQDKSHGMERIEVRSRSGNAHLGHVFTD
                     GPQEQGGLRYCINSAALRFIKKEEMEETGY"
     PFAM_domain     1576..1932
                     /aSDomain="SelR"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF01641.20"
                     /description="SelR domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_224_0072"
                     /evalue="9.80E-47"
                     /label="ctg1_224"
                     /locus_tag="ctg1_224"
                     /protein_end="293"
                     /protein_start="174"
                     /score="158.0"
                     /tool="antismash"
                     /translation="LKETLSEEAYQVTQHAATERPFQNEYFATFEEGIYVDVTTGEPLF
                     FAGDKFDSGCGWPSFTRPIAKDVIKYYQDKSHGMERIEVRSRSGNAHLGHVFTDGPQEQ
                     GGLRYCINSAALRFI"
     CDS             2286..3554
                     /locus_tag="ctg1_225"
                     /transl_table=11
                     /translation="MKAFKQVNLVTCDADFHVYRNGLLVIHEDKIVYCGNENATWVDRA
                     DEVVDCEGAWLMPGLVNCHTHSAMTTLRGIQDDSNLHEWLEDYIWPAERDSTPEVTTQA
                     VKLALIEMLQTGTTTFNDMYNPNGVEIGQIHEVVAGSKMRCYFSPTLFSSDVETTEETL
                     ARTRIIIEEILAYNDERFKVMVAPHAPYSCSKDLLKGSLKLAQELQLKLHIHVAETQAE
                     NGMILERYGKRPLAFLKDLGYLEHDGVFAHGVELNEREIAELAVSNIHIAHNPISNLKL
                     ASGIAPVTDLVQTGVIVGLATDSVASNNNLDMFEESRTAALLQKMRTGDATQFTIEQAL
                     KIMTIEGAKALGMDDQIGSLEVGKQADFLIIQPKGKVHLYPEENMLSHLIYAAKGNDVK
                     DVYIAGEQVVKNGQVLTVELSDL"
     PFAM_domain     2451..3509
                     /aSDomain="Amidohydro_1"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF01979.22"
                     /description="Amidohydrolase family"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_225_0073"
                     /evalue="3.10E-70"
                     /label="ctg1_225"
                     /locus_tag="ctg1_225"
                     /protein_end="408"
                     /protein_start="55"
                     /score="237.3"
                     /tool="antismash"
                     /translation="LMPGLVNCHTHSAMTTLRGIQDDSNLHEWLEDYIWPAERDSTPEV
                     TTQAVKLALIEMLQTGTTTFNDMYNPNGVEIGQIHEVVAGSKMRCYFSPTLFSSDVETT
                     EETLARTRIIIEEILAYNDERFKVMVAPHAPYSCSKDLLKGSLKLAQELQLKLHIHVAE
                     TQAENGMILERYGKRPLAFLKDLGYLEHDGVFAHGVELNEREIAELAVSNIHIAHNPIS
                     NLKLASGIAPVTDLVQTGVIVGLATDSVASNNNLDMFEESRTAALLQKMRTGDATQFTI
                     EQALKIMTIEGAKALGMDDQIGSLEVGKQADFLIIQPKGKVHLYPEENMLSHLIYAAKG
                     NDVKDVYIAGEQV"
     CDS             4289..4651
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: Lactococcin_972"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg1_226"
                     /sec_met_domain="Lactococcin_972 (E-value: 3.7e-09,
                     bitscore: 33.9, seeds: 6, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIKNIAFCIIIFHYCIYEEEENMVKIRTVVVTAFTILTFSLVLPV
                     FAVSHLGGEWNYGGHHDPRNWGAFSNYYHRDRYHFSYVGSLERNNERRPSVQAGHTSYA
                     FINTNFGERVTFDAGW"
     PFAM_domain     4442..4633
                     /aSDomain="Lactococcin_972"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF09683.12"
                     /description="Bacteriocin (Lactococcin_972)"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_226_0074"
                     /evalue="1.10E-10"
                     /label="ctg1_226"
                     /locus_tag="ctg1_226"
                     /protein_end="115"
                     /protein_start="51"
                     /score="41.9"
                     /tool="antismash"
                     /translation="GGEWNYGGHHDPRNWGAFSNYYHRDRYHFSYVGSLERNNERRPSV
                     QAGHTSYAFINTNFGERVT"
     aSDomain        4711..6702
                     /aSDomain="TIGR01654"
                     /aSTool="tigrfam"
                     /description="bact_immun_7tm: bacteriocin-associated
                     integral membrane protein"
                     /detection="hmmscan"
                     /domain_id="TIGRFam_ctg1_227_0023"
                     /evalue="3.10E-73"
                     /identifier="TIGR01654"
                     /label="ctg1_227"
                     /locus_tag="ctg1_227"
                     /protein_end="664"
                     /protein_start="0"
                     /score="245.3"
                     /tool="antismash"
                     /translation="MKRIFVVISNVLVCCFFIWVFTIISATVVSRYYPFVAVRGNASGI
                     QYKKVAEKLTKLANETNSLIAIQHYEAGSNGDSVVSYNRFGKGKLPRGLVEKADSKQAR
                     GVESNYFIFRGKLTVERLKEELNQLGLTHLSVVKPFLLGSLAAIFGSGFQLLSLFIFLL
                     CFAALSVISQIRALRTAGIRLISGEHRWKIFTDPIKEDFLSCLLGIFPALLGAVLATFV
                     FSFPFAALYLMVVGIFVYNLLLLGISFNFCALFAIGIKKVHLMQVIKGQIPVRGIISLI
                     LIGQLVAVIIVSLGINRAFIYSKAWQQQEKGRQAWAQESRLVQLTRSRDGLNIKRSEKI
                     DPKEWRWFQFVKEAVAKHDALLSKHNLVQQVFKQPTERHSDWQDYSPQGNVLFVTPNYL
                     QKQGIKLDSAIREKINNLQQGEFALLLPESLKAEQKKYTVLYEKDVSMIASRQGEEQQK
                     MKAIVSYLPVNQMRFVYNTTPIAYQQYLKDPIIVVLTPQSTGEQSYEFWSNTLQNDLLL
                     NGVKETQELLQKYQISHWASELTPARLVYRRIVEKLQIEIWMTIAGAVLGIVTSILLFN
                     TMNLLYFEEFRRDIFIKQVSGFTFWELHHSYLLAQLLVFFLGLLASLFLTQSIWLSFIV
                     FLLFTGNSVVLLQLQMKKESKMSVMILKG"
     CDS             4711..6708
                     /locus_tag="ctg1_227"
                     /transl_table=11
                     /translation="MKRIFVVISNVLVCCFFIWVFTIISATVVSRYYPFVAVRGNASGI
                     QYKKVAEKLTKLANETNSLIAIQHYEAGSNGDSVVSYNRFGKGKLPRGLVEKADSKQAR
                     GVESNYFIFRGKLTVERLKEELNQLGLTHLSVVKPFLLGSLAAIFGSGFQLLSLFIFLL
                     CFAALSVISQIRALRTAGIRLISGEHRWKIFTDPIKEDFLSCLLGIFPALLGAVLATFV
                     FSFPFAALYLMVVGIFVYNLLLLGISFNFCALFAIGIKKVHLMQVIKGQIPVRGIISLI
                     LIGQLVAVIIVSLGINRAFIYSKAWQQQEKGRQAWAQESRLVQLTRSRDGLNIKRSEKI
                     DPKEWRWFQFVKEAVAKHDALLSKHNLVQQVFKQPTERHSDWQDYSPQGNVLFVTPNYL
                     QKQGIKLDSAIREKINNLQQGEFALLLPESLKAEQKKYTVLYEKDVSMIASRQGEEQQK
                     MKAIVSYLPVNQMRFVYNTTPIAYQQYLKDPIIVVLTPQSTGEQSYEFWSNTLQNDLLL
                     NGVKETQELLQKYQISHWASELTPARLVYRRIVEKLQIEIWMTIAGAVLGIVTSILLFN
                     TMNLLYFEEFRRDIFIKQVSGFTFWELHHSYLLAQLLVFFLGLLASLFLTQSIWLSFIV
                     FLLFTGNSVVLLQLQMKKESKMSVMILKGA"
     PFAM_domain     6403..6702
                     /aSDomain="DUF1430"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF07242.13"
                     /description="Protein of unknown function (DUF1430)"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_227_0075"
                     /evalue="1.30E-23"
                     /label="ctg1_227"
                     /locus_tag="ctg1_227"
                     /protein_end="664"
                     /protein_start="564"
                     /score="83.3"
                     /tool="antismash"
                     /translation="VLGIVTSILLFNTMNLLYFEEFRRDIFIKQVSGFTFWELHHSYLL
                     AQLLVFFLGLLASLFLTQSIWLSFIVFLLFTGNSVVLLQLQMKKESKMSVMILKG"
     CDS             6710..7339
                     /gene_functions="transport (smcogs) SMCOG1000:ABC
                     transporter ATP-binding protein (Score: 170.1; E-value:
                     1e-51)"
                     /gene_kind="transport"
                     /locus_tag="ctg1_228"
                     /transl_table=11
                     /translation="MIRLEKVSKQFGERLLFSDISIEFKAGKTYALIGLSGSGKTTLLN
                     MLAKLESYEGQIIYRGKNLKQYKTSDFFRKELGYLFQNFGLLENQTIDENLRLGLIGQK
                     LKKDERQKRELEALKNVGLDYLDLGKRIFELSGGEAQRVALAKIILKNPPLILADEPTA
                     ALDPETSKDIMTRLIALKNDHRVIVIATHNPIIWEMADEVISIHDL"
     aSDomain        6719..7327
                     /aSDomain="TIGR03608"
                     /aSTool="tigrfam"
                     /description="L_ocin_972_ABC: putative bacteriocin export
                     ABC transporter, lactococcin 972 group"
                     /detection="hmmscan"
                     /domain_id="TIGRFam_ctg1_228_0024"
                     /evalue="7.00E-78"
                     /identifier="TIGR03608"
                     /label="ctg1_228"
                     /locus_tag="ctg1_228"
                     /protein_end="206"
                     /protein_start="3"
                     /score="258.8"
                     /tool="antismash"
                     /translation="LEKVSKQFGERLLFSDISIEFKAGKTYALIGLSGSGKTTLLNMLA
                     KLESYEGQIIYRGKNLKQYKTSDFFRKELGYLFQNFGLLENQTIDENLRLGLIGQKLKK
                     DERQKRELEALKNVGLDYLDLGKRIFELSGGEAQRVALAKIILKNPPLILADEPTAALD
                     PETSKDIMTRLIALKNDHRVIVIATHNPIIWEMADEVISI"
     PFAM_domain     6761..7198
                     /aSDomain="ABC_tran"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00005.29"
                     /description="ABC transporter"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_228_0076"
                     /evalue="8.20E-33"
                     /label="ctg1_228"
                     /locus_tag="ctg1_228"
                     /protein_end="163"
                     /protein_start="17"
                     /score="113.9"
                     /tool="antismash"
                     /translation="SDISIEFKAGKTYALIGLSGSGKTTLLNMLAKLESYEGQIIYRGK
                     NLKQYKTSDFFRKELGYLFQNFGLLENQTIDENLRLGLIGQKLKKDERQKRELEALKNV
                     GLDYLDLGKRIFELSGGEAQRVALAKIILKNPPLILADEPTA"
     CDS             complement(7603..8781)
                     /gene_functions="other (smcogs) SMCOG1108:ROK family
                     protein (Score: 159.2; E-value: 2.7e-48)"
                     /gene_kind="other"
                     /locus_tag="ctg1_229"
                     /transl_table=11
                     /translation="MNQTKKQAELRTIILDKIYAKGPISRIDISKETGITPATVSAITG
                     SLIQEKLLYELGEDEEHTKVGRKKILLGIKKQHSYFIGCELSEKYFSFVLSDNTGNVID
                     KEKATVSSEKILSEGADSFCHLLRQFISQHVSYPIQAVGVAIPGRYLHNDLITTNNQTW
                     KQFDLAKIKNEFSFPIYFSNNVNCMALAKRLFSAYQLDENFIYFHFARGMHCSYMYNGK
                     IYGKTNIVIGEIGHTVVCPDGEVCGCGRRGCLQTYASESWLIKKAKIIFETAELTHLKS
                     LVTDKEEITIQTILTAYNLGDQSVLNILHLAFKYLAQSLLNLSMIIDAKKIYLHSPILT
                     DDKVIAAFYQEIAQQPKLLFKDLPELIIEPYDDFTGAIAGVALCLQKEFLSI"
     PFAM_domain     complement(7633..8535)
                     /aSDomain="ROK"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00480.22"
                     /description="ROK family"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_229_0077"
                     /evalue="7.10E-36"
                     /label="ctg1_229"
                     /locus_tag="ctg1_229"
                     /protein_end="383"
                     /protein_start="82"
                     /score="124.3"
                     /tool="antismash"
                     /translation="GCELSEKYFSFVLSDNTGNVIDKEKATVSSEKILSEGADSFCHLL
                     RQFISQHVSYPIQAVGVAIPGRYLHNDLITTNNQTWKQFDLAKIKNEFSFPIYFSNNVN
                     CMALAKRLFSAYQLDENFIYFHFARGMHCSYMYNGKIYGKTNIVIGEIGHTVVCPDGEV
                     CGCGRRGCLQTYASESWLIKKAKIIFETAELTHLKSLVTDKEEITIQTILTAYNLGDQS
                     VLNILHLAFKYLAQSLLNLSMIIDAKKIYLHSPILTDDKVIAAFYQEIAQQPKLLFKDL
                     PELIIEPYDDFTGAIAGVAL"
ORIGIN
        1 atggtatcaa ctcaaacaca aattgctggt ttttcttttg acaattgcct gatgaatgcg
       61 gctggagtag cttgtatgac aatagaggag ctagaaaaag tcaaacagtc tgctgcagga
      121 acctttgtca ctaagacagc cactttgcaa gcccgagcag gaaatcctga acctcgttac
      181 caagatgtac cgctaggctc tatcaattca atggggttac caaatcatgg actagattac
      241 tatctggatt acttattaga tttgcaaaag atagagccca atcgaacatt ctttttatct
      301 cttgtgggat tgtcgccaga agaaacccac acgcttctga aaaaggtgca ggatagtgat
      361 tttaaaggtt tgactgagct caatctttcc tgccccaatg tacctggtaa accgcagatt
      421 gcttatgatt ttgaaatgac agataaaatt ttgagtgacg tatttgatta tttcaccaaa
      481 ccgctgggga ttaaattacc accttatttt gatattgtgc attttgatca agcagcagca
      541 atttttaata aattcccact ttgttttgtc aattgtgtca attcaattgg taacggtttg
      601 tatgttgagg atgaatcagt tgttatccgt ccgaaaaatg ggtttggcgg aattggtggg
      661 gcgtatatta aaccgactgc tcttgctaat gttcatgctt tctatcaacg tctcaatcct
      721 actattcaaa tcattggtac aggtggtgtg ttgactggtc gagatgcttt tgaacatatt
      781 ctctgtggag ccagcatggt acaagtcgga acaacgcttc acaaagaggg tgtagagtcc
      841 tttgagcgta ttacagaaga gctgaaggtg atgatggcag aaaaaggcta cgaaagtata
      901 gaagattttc gtgggaaatt gaaccacctg aattaattag aggagacgtt acagtatttc
      961 tttgtcgtat cattttaaag aaacttctaa tcaaatcctt ataatatttt aggaatttgt
     1021 gagaaaataa gaataaagaa atgaggtgtt tttatgtcag aaatttatct agcaggtggt
     1081 tgtttttggg gattggaaga atatttttct cgtatcaaag gggtgactga tacaactgtc
     1141 ggttatgcca atggacaagt agaatcgaca aattatcagt tgattcacca aactgatcat
     1201 gctgaaacag ttcaggtgac ctatgatgac aatcttgtta cgttgcgaga aattttgctt
     1261 tattacttcc gagtgattga tcccttatct atcaataagc aagggaatga tattgggcgc
     1321 caataccgca cagggattta ttatacaaat gatacggatg cacccatcat tgccgaagtc
     1381 acgaaagagc aggaagagca atttggtcag aagattgcag tagaagtaga accgctgcgc
     1441 cattatgttt tagcagagga atatcaccaa gattatctca agaaaaatcc cagtggctat
     1501 tgtcatatca atgtcaatga tgcttaccaa cctttagtag acccgagtca gtatgaaaaa
     1561 ccgagtgagc taactttaaa ggagacactg tctgaagaag cttatcaggt cacccaacat
     1621 gctgcaactg aacgaccatt ccaaaatgag tattttgcaa cttttgaaga aggcatttat
     1681 gtagatgtga caacaggaga accactgttt tttgccggtg ataagtttga ttctggttgt
     1741 ggttggccaa gctttacaag accaattgcc aaagatgtga ttaagtatta tcaagataaa
     1801 agtcacggta tggagcgaat tgaggtgcgt tctcgctctg ggaatgcgca tttagggcat
     1861 gttttcacag atggtccgca ggaacaaggc ggtttgcgct actgtattaa ttcagcagcg
     1921 ttacgcttta tcaaaaaaga agaaatggaa gaaacaggct atggctattt actttcatat
     1981 atgagatgaa gaggatgcgt tcagtttatc acttgttctt gtgcttcaga acttgctatt
     2041 taggacgtat tttgctacaa taactaaaaa ttcatgaaaa catataatct ccataataag
     2101 gttggagagt ttctaccgtc ttaccgtaaa taagcgtggc atagtcctta gttatgttgt
     2161 caaacacaaa tagagtatca ggttaaatgt taagtagttg taggatagct atgttgtgtt
     2221 ctaccctgcc ctgctcctaa atataagacc tgaatggctc tgatatttgc tttaaaggag
     2281 aaggaatgaa agcatttaaa caggtgaatt tggtaacatg tgatgcagat tttcacgtct
     2341 atcgaaatgg actactggta atacatgagg ataagattgt ctattgtgga aatgagaatg
     2401 ctacttgggt agatcgagca gatgaggtgg tagattgtga aggcgcgtgg cttatgcctg
     2461 gtctagtgaa ttgtcacacc cattctgcaa tgactacgct tcgtggtatt caagatgata
     2521 gcaatcttca cgaatggcta gaagattaca tttggccagc agagagggac tctactccag
     2581 aagtgacgac acaagcggtt aagttagcgc ttatagaaat gcttcagacg ggaacaacga
     2641 cctttaatga tatgtataat ccaaatggtg tggaaattgg gcaaattcat gaagttgtag
     2701 caggttctaa aatgcgttgt tatttttcac caactttgtt tagctcagat gtagagacaa
     2761 cagaagaaac cttagcacgt actcggatta ttattgagga aattctagca tacaatgatg
     2821 aacgttttaa agtaatggtg gcaccgcacg ctccttatag ttgcagtaag gacttgttaa
     2881 aaggcagttt gaagctagcg caagaattgc aattgaaatt gcacatccat gtggcagaga
     2941 cacaagcaga aaatggtatg attttagagc gttatggaaa acgtccgctt gccttcttaa
     3001 aggacttagg gtatctggag catgatggtg tctttgctca tggtgtagaa ttaaatgaac
     3061 gagaaattgc tgaattagca gtatcaaata ttcatatcgc tcataatcct atcagcaatc
     3121 tcaaattagc atcagggatt gctcctgtaa cagacttagt tcaaactggt gtaatagtcg
     3181 gacttgcaac ggattcggtt gcttctaaca acaatttaga tatgtttgaa gagagccgta
     3241 ccgctgccct tttacagaaa atgcgcacag gtgatgcaac tcaatttacc attgagcaag
     3301 ctctgaaaat aatgacgatt gagggagcta aagcacttgg tatggatgat cagattggca
     3361 gcttagaagt tggtaagcaa gcagattttt taatcattca gccgaaagga aaggtgcact
     3421 tgtatccaga ggaaaacatg ctctctcacc tgatctatgc tgctaaagga aatgatgtta
     3481 aagatgtcta tatagctggt gagcaggtcg taaaaaatgg acaggttcta acagtagaat
     3541 tgagtgattt ataagaaaat gcattataag ttatagtaaa aagaagagac tgggacacaa
     3601 gtgtttcaat gcaaaaaaac aacggttttg ctgccgttgt ttttttgcat taaattaggg
     3661 atacagttgt ctatgtctat tcctctaacc tttcgagcta tgcggaggga cgtagagtca
     3721 gatgatgtgt tagctttggg aggattattg catgttgaga atttatactc tctagggtgt
     3781 cgatcatcat cggctgttag tgcgtggaca gcgtgttgcc aatgcttgta actataaagc
     3841 ggctgtcgaa tctgaaacaa ttcaagtaac accgatttta gtagtgctag ttatagcagt
     3901 tatttatgtg ttctattatt ggataaacat ccatgattgc tcaaagtact attataagtc
     3961 tgtaaaataa gcccccctct cgattaatac tctgtgaaaa tctcttcaaa ctttgtccgc
     4021 ttcactttgc tgtactccag tatggcttgt ggatcgattc ttagtgctgt ttgattgtta
     4081 gtgaagtata aaaaatggat tttatgaatg atagtttaaa gcgactcttt cgtataatta
     4141 agagtacttt ttctttttgt tcgccggcaa aatagataga tttgtagagt tgacaaatag
     4201 atatttgagg catataataa aagtgtgaaa gcgcttctct gtagaaagga tagaaaaacg
     4261 gaaacgatat tcagatagcc gcttgtcaat gataaaaaat attgcctttt gcattattat
     4321 atttcattat tgtatttatg aagaagaaga aaatatggta aagatacgaa cagtagttgt
     4381 tactgcattc acaatcttaa cattttcatt agtgttgcca gtttttgcag tttcacacct
     4441 gggtggcgaa tggaattatg gcggccatca cgatccaaga aattggggtg ctttttctaa
     4501 ttattatcat agagataggt atcacttttc ctatgttgga agcttagaaa gaaataatga
     4561 acgtcgacca tcggtgcagg ctggtcatac atcttatgct tttattaaca ctaattttgg
     4621 ggagagagtc acttttgatg ctggttggtg aggttgttat aggcaggagg agacgatttt
     4681 cgtctccttt ttaaagaaaa ggagcagaat atgaaacgga tatttgtagt gatttctaat
     4741 gtgctagtct gctgtttttt tatatgggta tttactatta tatcagctac agtggtctcg
     4801 cgttattatc catttgttgc tgtgagaggc aatgcatcgg gtattcaata taaaaaagta
     4861 gctgaaaagc tgactaagtt agcaaatgaa acgaatagtt tgattgcgat acaacactat
     4921 gaggcaggtt ccaatggtga ttctgtggtt tcatataatc gctttggcaa agggaaattg
     4981 ccaagaggtt tagtagaaaa agctgactcc aaacaggcaa gaggcgttga atccaattac
     5041 tttattttta gaggaaaact aacggttgag cggttaaaag aggagcttaa ccagttaggt
     5101 ttaacgcact tatcagtggt gaagcctttt ctccttggtt cattagcggc tatttttggc
     5161 agtggatttc agttattgag cttgtttatc ttcttgcttt gttttgccgc tcttagtgtt
     5221 attagtcaga ttcgggcttt gagaactgcg gggattcggt tgatttcagg tgagcatcgt
     5281 tggaaaatct ttactgaccc aattaaagaa gatttcctaa gttgtttgct gggaattttt
     5341 cctgctcttt tgggtgcagt acttgcgacc tttgtctttt cttttccctt tgctgcattg
     5401 tacttaatgg ttgtaggaat attcgtctat aatctactac tattggggat ttctttcaat
     5461 ttttgcgctc tatttgcgat aggaattaaa aaagttcatc ttatgcaagt tatcaaaggg
     5521 cagattcctg tcagagggat catcagtttg attttgatag ggcagttagt cgcggttatc
     5581 attgtttctt tgggaattaa tcgagctttc atctattcga aagcttggca acagcaagag
     5641 aaaggaagac aagcctgggc gcaggaaagt cgactagtac agttgactcg cagtcgagat
     5701 ggactaaaca taaaacgttc tgagaaaatt gatccgaaag agtggcgttg gttccagttt
     5761 gttaaggagg ctgttgccaa gcatgatgcg ttactgagta agcataattt agtacaacaa
     5821 gtttttaaac aaccgactga aagacattca gattggcagg attacagccc acagggaaat
     5881 gttttatttg tcacgccgaa ctatctccaa aaacaaggta taaaacttga ttcagccata
     5941 agagaaaaga taaacaattt gcagcaagga gagtttgctt tacttttgcc agaaagcttg
     6001 aaagcagagc aaaaaaagta cactgtattg tacgaaaaag atgtatcaat gatcgcttct
     6061 cgtcagggag aagaacaaca aaaaatgaaa gcgatagtgt cttatcttcc agtcaatcaa
     6121 atgcgatttg tgtataatac aaccccgatt gcttatcagc aatatttaaa agaccccatt
     6181 atagtagttc tgacacctca gtctacagga gagcaatctt atgaattttg gagcaatacg
     6241 ttacaaaatg atcttctttt gaatggtgta aaagaaacac aagagttgtt gcaaaaatac
     6301 caaatttctc actgggcatc tgagttgact cccgctcgac tggtttaccg aaggatagtc
     6361 gagaaacttc aaattgaaat ctggatgaca attgcaggag ctgtcttagg aatagtgact
     6421 tcgattttgc tctttaatac gatgaactta ctttattttg aggaatttcg acgagatatt
     6481 tttattaaac aagtttctgg attcactttt tgggaattgc atcactctta tttattggca
     6541 caattattgg tgtttttcct tgggctgtta gctagtctct ttttgacaca aagcatttgg
     6601 ctgagtttta tagtattttt gctatttact ggaaattctg tagtattatt gcagcttcaa
     6661 atgaagaaag aaagtaaaat gtctgtgatg attttgaaag gggcataaga tgattcgttt
     6721 agaaaaagta agtaaacaat ttggagaacg gctgctattt tcggatattt ctattgaatt
     6781 taaggcaggt aaaacatatg ctctaatcgg attaagtggt agcggcaaaa caaccttgtt
     6841 aaatatgctg gcaaaattag agagttatga aggtcaaatt atttatcgtg gaaagaattt
     6901 gaaacaatat aaaaccagcg actttttccg caaggaactg ggctatcttt ttcaaaattt
     6961 tggtttatta gaaaatcaaa cgattgatga aaatttaaga ttaggtttaa ttggacaaaa
     7021 gttgaaaaaa gatgagcggc aaaagaggga attagaagct ctaaaaaatg tagggttgga
     7081 ctatcttgac ttaggcaaaa ggatttttga actatctggt ggtgaggctc agcgtgttgc
     7141 cttggctaaa attatcttaa aaaatccgcc tcttatcttg gcggatgaac caacagctgc
     7201 ccttgatcct gaaacatcaa aagatattat gacaagactg atagctttaa aaaatgacca
     7261 tagagtcatt gttattgcaa cgcataatcc tatcatttgg gagatggcag atgaagttat
     7321 ttctattcat gatttgtaaa tgtgaaataa ttttacttat attgccttta gcttcttttg
     7381 ttgaaatatg agagaaacag agagtagaat aaaaattagt aacgcgaggg gatcgctctg
     7441 cctccgcaag aatggctagg tctgacaaaa gttgttacac taatttcaga ctatttagca
     7501 aatacatctt gtagtttata gtaaaaaatt agaggtttgt gacagttgtc ctaacctctt
     7561 ttgtaataaa aatacgcact aagttcagaa gtcataataa agttaaatag acaaaaattc
     7621 tttttgcaga caaagcgcaa cgccagctat tgcgccagtg aagtcatcgt aaggctcgat
     7681 gatgagttca ggtaagtctt tgaagagtaa ttttggctgt tgggcaattt cttggtagaa
     7741 tgctgcaatg actttgtcat cagtcagaat ggggctgtgc agataaattt tcttggcatc
     7801 aattatcata ctgaggttga gaagggattg tgccagatac ttaaatgcca aatgcaagat
     7861 attgaggacg gattggtctc ctaagttgta tgccgtaaga atagtttgaa tcgtgatctc
     7921 ttctttatct gtgacaagtg attttaaatg tgttaactcg gcagtttcaa agatgatttt
     7981 agcttttttt atcagccagc tttcactagc ataagtctgc aaacagcctc tgcgtccaca
     8041 accacagact tctccgtcag gacaaacgac ggtatgacca atttcgccga tgacaatatt
     8101 ggttttgccg tagattttgc cattgtacat ataagagcag tgcatacccc ttgcaaaatg
     8161 aaaatagata aaattctcat ccagttggta agcagaaaaa aggcgctttg ctagtgccat
     8221 gcaattgaca ttattagaaa agtaaattgg aaaagaaaac tcgtttttaa tcttcgctaa
     8281 atcaaattgt ttccatgttt gattatttgt tgtaatcaaa tcattgtgca gatatcgccc
     8341 tggaatggct actcctacag cctgaatcgg ataggataca tgttgagaaa tgaattgtct
     8401 cagtaagtga caaaatgaat ctgcaccttc tgacagaatc ttttctgagc tgacagttgc
     8461 tttctcttta tcaatcacat ttcctgtatt atcactcaac acaaaagaaa aatatttttc
     8521 tgatagttcg caaccgatga aataagagtg ctgttttttt atacccaaga ggattttctt
     8581 tcgcccgact tttgtgtgtt cttcatcttc ccccagctca tacagcagtt tttcttggat
     8641 caaacttcct gtaatcgcac taactgtagc aggagtaatg cccgtctctt ttgaaatatc
     8701 aatgcgagaa attggcccct tggcgtaaat tttatctaaa ataattgttc gtaattcagc
     8761 ttgttttttc gtttgattca t
//
