LOCUS       NZ_CP009728.1          10852 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  NZ_CP009728.1 Burkholderia mallei strain Turkey2 chromosome 2,
            complete sequence.
ACCESSION   NZ_CP009728
VERSION     NZ_CP009728.1
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 6.1.1
            Run date     :: 2024-03-14 13:03:12
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 23170
            Orig. end    :: 34022
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..10852
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[28170:29022](+)"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193)"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      5001..5852
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193)"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
     cand_cluster    1..10852
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193)"
                     /kind="single"
                     /product="RiPP-like"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..10852
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="RiPP-like"
                     /region_number="1"
                     /rules="(strepbact or Antimicrobial14 or Bacteriocin_IId or
                     BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or
                     Lactococcin or Antimicrobial17 or Lactococcin_972 or
                     Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or
                     TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or
                     TIGR03975 or DUF692 or TIGR01193)"
                     /tool="antismash"
     CDS             complement(87..323)
                     /locus_tag="ctg2_21"
                     /transl_table=11
                     /translation="MTRHHTHAGIPRTLKIVGYCGLAAIALALFVAMCAILKDSALDRE
                     AARQLQNGNVELHGGADVEPGSTNDAAQARTPG"
     CDS             complement(1089..1916)
                     /gene_functions="other (smcogs) SMCOG1200:vibriobactin
                     utilization protein ViuB (Score: 274.2; E-value: 1.6e-83)"
                     /gene_kind="other"
                     /locus_tag="ctg2_22"
                     /transl_table=11
                     /translation="MTQPTTERAVVRVRHTLKFRLLQVKRVVDVTPHLKRVTLAGDELD
                     DFESASFDDHVKVFFPPPGEDAPARPEFGPNGIVFPQDRPRPVARDFTPRRYDRAAREL
                     DLDFVLHHPGPASQWAAQARVGQTLGIGGPRGSFVIPKDFDWHLLIGDDTALPAVARRL
                     EELPAGTRVAAVLEVADPSAQIAFETDANLYVVWRHRGDAASGERGASRLVDALRELPL
                     PAGEGYVWAAGEAAAMRGVREHLCRERGVAKSRIRASAYWKHGAIAVHESLED"
     PFAM_domain     complement(1122..1484)
                     /aSDomain="SIP"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF04954.15"
                     /description="Siderophore-interacting protein"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg2_22_0002"
                     /evalue="4.70E-39"
                     /label="ctg2_22"
                     /locus_tag="ctg2_22"
                     /protein_end="265"
                     /protein_start="144"
                     /score="133.7"
                     /tool="antismash"
                     /translation="DWHLLIGDDTALPAVARRLEELPAGTRVAAVLEVADPSAQIAFET
                     DANLYVVWRHRGDAASGERGASRLVDALRELPLPAGEGYVWAAGEAAAMRGVREHLCRE
                     RGVAKSRIRASAYWKHG"
     PFAM_domain     complement(1506..1850)
                     /aSDomain="FAD_binding_9"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF08021.13"
                     /description="Siderophore-interacting FAD-binding domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg2_22_0001"
                     /evalue="2.70E-37"
                     /label="ctg2_22"
                     /locus_tag="ctg2_22"
                     /protein_end="137"
                     /protein_start="22"
                     /score="127.8"
                     /tool="antismash"
                     /translation="QVKRVVDVTPHLKRVTLAGDELDDFESASFDDHVKVFFPPPGEDA
                     PARPEFGPNGIVFPQDRPRPVARDFTPRRYDRAARELDLDFVLHHPGPASQWAAQARVG
                     QTLGIGGPRGS"
     CDS             complement(1956..2663)
                     /locus_tag="ctg2_23"
                     /transl_table=11
                     /translation="MRHAHRFSRRECGMSDSFGHSPFEMFRQMFGGHRRGGGRHGFGPF
                     GGFGGGGPGGFGGFGDDAMPRGRQFSADDLQLLLLALLAEQPSHGYELIKALDTRSSGF
                     YAPSPGMVYPALTYLEELGYVTVQAEGNRKRYALADAGRAHLDAQRERVEMLFAKLAHL
                     GRKMEFMRRAFAGEAPAAPEDDTRGWLPEFVEARMALKQALFRRSGANADEQRRIAAIL
                     RRAVADIEGRAQG"
     PFAM_domain     complement(2223..2429)
                     /aSDomain="PadR"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF03551.16"
                     /description="Transcriptional regulator PadR-like family"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg2_23_0003"
                     /evalue="2.90E-19"
                     /label="ctg2_23"
                     /locus_tag="ctg2_23"
                     /protein_end="147"
                     /protein_start="78"
                     /score="68.9"
                     /tool="antismash"
                     /translation="LLALLAEQPSHGYELIKALDTRSSGFYAPSPGMVYPALTYLEELG
                     YVTVQAEGNRKRYALADAGRAHLD"
     CDS             2810..2998
                     /locus_tag="ctg2_24"
                     /transl_table=11
                     /translation="MPECRVQGWGDGDGRRRHGEPGPWPVRSMADVYPSRGVPYCATAL
                     RSRSGGTGRAASEDVIL"
     CDS             3071..4477
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) p450"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1034:cytochrome P450 (Score: 212.7; E-value: 1.6e-64)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg2_25"
                     /sec_met_domain="p450 (E-value: 5.5e-35, bitscore: 117.7,
                     seeds: 50, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNGLPLSLPRVDSTDSLFADPLAFLARARAQCGDVFVLREHGPIF
                     SRASDCSGVIAVFGEHRLRQVLTETDTFALPMSAAAKMALPKNLVNLNRGLHSMREPEH
                     GRHKRLLTGTANRALFDAHRSGMQTDLSRFCEMLNGDGRISVVSRMRELTAKLASRLFL
                     GPQCEEDAELTFLLSAYFTLRREASSPNAHDPLQYRDALIGAGRQLDRALRARIRRYRK
                     APAGECAGLLQRLATAGQPGSPALSEDEIVGHANVMFVSSTEPVAISLAWLLLVLSQLP
                     DLRRALRAESAARASSPASPYDAPLLERVINETLRLLTPNALMVRATTQAVSLQGVALP
                     ARCEIVVCPFLVHREANAFARPHAFLPSRWETARPSPYEYFPFGAGGHFCAGRNLALSL
                     IGEVLSTLLSRFDFVLDIEQFIDWRIHIMLMPKGDPTLTAHPVDERRDTPSPKWRGPVA
                     ELFHFAPGLS"
     PFAM_domain     3764..4318
                     /aSDomain="p450"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00067.24"
                     /description="Cytochrome P450"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg2_25_0004"
                     /evalue="6.20E-34"
                     /label="ctg2_25"
                     /locus_tag="ctg2_25"
                     /protein_end="416"
                     /protein_start="231"
                     /score="117.6"
                     /tool="antismash"
                     /translation="LQRLATAGQPGSPALSEDEIVGHANVMFVSSTEPVAISLAWLLLV
                     LSQLPDLRRALRAESAARASSPASPYDAPLLERVINETLRLLTPNALMVRATTQAVSLQ
                     GVALPARCEIVVCPFLVHREANAFARPHAFLPSRWETARPSPYEYFPFGAGGHFCAGRN
                     LALSLIGEVLSTLLSRFDFVLD"
     CDS             4627..4827
                     /locus_tag="ctg2_26"
                     /transl_table=11
                     /translation="MATKPKKTKGVSVSIEGKLPKMTLDMPVDAKKIKAIQKCLENGKL
                     TITMSKVDLAGGRMGEGYLYD"
     CDS             5001..5852
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: DUF692"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg2_27"
                     /sec_met_domain="DUF692 (E-value: 5.7e-35, bitscore: 117.5,
                     seeds: 7, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKAFDRDAGAPRIGLAYGPGMAEFAARHAHLVDYIEVPFELLRFS
                     PTIAELQQTIPFVLHCASLSVAGFVPPDDSTVDAIERTAVRTGTPWIGEHLAYISADPI
                     GEALGGTHEPTSLSYTLCPQLSDETVRRVADNLAVLAPRFPVPLIVENSPQYFSIPGST
                     MGMTDFIRAIADRCDVGLLLDLSHFLITAYNTGADVHREFARLPLERVVEVHLSGMSIQ
                     SGAAWDDHSLPASPILFELLERLLAVARPRALTFEYNWSPYFPLSVLTSHIERARALMG
                     LA"
     PFAM_domain     5037..5837
                     /aSDomain="DUF692"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF05114.15"
                     /description="Protein of unknown function (DUF692)"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg2_27_0005"
                     /evalue="2.10E-39"
                     /label="ctg2_27"
                     /locus_tag="ctg2_27"
                     /protein_end="279"
                     /protein_start="12"
                     /score="135.4"
                     /tool="antismash"
                     /translation="IGLAYGPGMAEFAARHAHLVDYIEVPFELLRFSPTIAELQQTIPF
                     VLHCASLSVAGFVPPDDSTVDAIERTAVRTGTPWIGEHLAYISADPIGEALGGTHEPTS
                     LSYTLCPQLSDETVRRVADNLAVLAPRFPVPLIVENSPQYFSIPGSTMGMTDFIRAIAD
                     RCDVGLLLDLSHFLITAYNTGADVHREFARLPLERVVEVHLSGMSIQSGAAWDDHSLPA
                     SPILFELLERLLAVARPRALTFEYNWSPYFPLSVLTSHIERARAL"
     CDS             5849..6682
                     /locus_tag="ctg2_28"
                     /transl_table=11
                     /translation="MNARTIHALIAASTKDPQLIERWRRHPDLLRGAGIAPGDLDWRAL
                     EHFVGLSLKVRHNGLRGDFPLSFRLLSVVGLEIEVFAAYASDCAESGHVFAATPQERAR
                     DLIAFLDRWLDPAQRNHVLLWDILRHEYALACLRQAGDAPLADARPAARHRARATAGGI
                     PTLNGSVVQHVMRCNPDDLAAALHQKEPPLDAVPAVDTYCCYWRSAETGEIRLLRVDTL
                     GYFAIEAIDGRRSAADICHRLLGNRRLLPQFLSSLDQLAGIGIVRFARPLGCAAA"
     CDS             6679..8622
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF04055"
                     /gene_functions="other (smcogs) SMCOG1277:Radical SAM
                     domain protein (Score: 260.4; E-value: 4.9e-79)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg2_29"
                     /sec_met_domain="PF04055 (E-value: 4.8e-14, bitscore: 49.8,
                     seeds: 518, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKLLLVDNLVMPEEGSLAYLDVHPHLGLLALAAVAEADGHRVRIY
                     DPKRLIRDGTLAYDATLYERASRAILAERPDAVGFTALGCSFLFALNVAALLKRREPDL
                     PVLLGGPHATMLHRQILERFPQFDIIVRYEADEILPAVLDCLEQRTFDVIPGLSWRATG
                     RGAPLRFTDGKPKVEELDRLPIASYDHYPVDDLGFSMLRIEAGRGCPFACTFCSTAGFF
                     QRSFRLKSAERLVHELDILHRRYRVSDFKLDHDMFTVNRHKVMAFCEAVAGRGYRWRAS
                     ARIDCVDEALLRKMADAGCVNLYFGVETGSERMQTICRKRLDLRLVEPILAAADSFGIE
                     TTASFITGYPQESGQDQDDTLDMIGRCARRPSCLTQLHMLAPEPGTPLFDEHGAQIAYD
                     GYGGPYNTRLLGPEDEREVLDHPDIFQTYYYYPAALPRARHIFAVEAVDVLRRAGPIIL
                     AYALREFGGRLSRLISAWRRFADETSPGALPDAAGLEAFVAARFGRGHHLHSLFRYALR
                     LSAARAPADVVAEGPYEPDRPCMLAENVGLLEDIHNCEALVDRLRRSNDGAPALGDADV
                     GGLGAYIVRADGEAVTGYWVESGIAAILDLFRAPRSCRAAAQWLAHVTRNDGVDASIFE
                     LLLRRGILVPAR"
     PFAM_domain     6742..7104
                     /aSDomain="B12-binding"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF02310.21"
                     /description="B12 binding domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg2_29_0006"
                     /evalue="2.20E-17"
                     /label="ctg2_29"
                     /locus_tag="ctg2_29"
                     /protein_end="142"
                     /protein_start="21"
                     /score="63.3"
                     /tool="antismash"
                     /translation="VHPHLGLLALAAVAEADGHRVRIYDPKRLIRDGTLAYDATLYERA
                     SRAILAERPDAVGFTALGCSFLFALNVAALLKRREPDLPVLLGGPHATMLHRQILERFP
                     QFDIIVRYEADEILPAV"
     PFAM_domain     7288..7767
                     /aSDomain="Radical_SAM"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF04055.23"
                     /description="Radical SAM superfamily"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg2_29_0007"
                     /evalue="9.00E-13"
                     /label="ctg2_29"
                     /locus_tag="ctg2_29"
                     /protein_end="363"
                     /protein_start="203"
                     /score="49.0"
                     /tool="antismash"
                     /translation="EAGRGCPFACTFCSTAGFFQRSFRLKSAERLVHELDILHRRYRVS
                     DFKLDHDMFTVNRHKVMAFCEAVAGRGYRWRASARIDCVDEALLRKMADAGCVNLYFGV
                     ETGSERMQTICRKRLDLRLVEPILAAADSFGIETTASFITGYPQESGQDQDDTLDM"
     CDS             8636..9625
                     /locus_tag="ctg2_30"
                     /transl_table=11
                     /translation="MARRKLERWSALDLAEGLQLAHAVAALQTLGVVDAMAEPTTAQTL
                     SAACDLDPELLRGVLEYAASRTNLIRKTGDRFAASEHYTAQARFLLNLYAGAYADNASR
                     LATLLRRPALAGTTVDLVAHARAFEASEAGGGALAAIISQLHLNHVLDLGCGAGTLLHA
                     LVADDREFVGWGLDRNPSMCKAARMRARQAGIAARVKVFQGDGRHPGASIPPRVLARVR
                     NVVASQFVNEMFRGGTSRAQAWLRRMRRLLPDRLLVIADYYGRLGHGFQTPHRETLLHD
                     YAQLISGQGVPPPNADAWLAMYRAAGCRPLHVIEDRAATTRFVHLVAL"
     PFAM_domain     9083..9259
                     /aSDomain="Methyltransf_25"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF13649.8"
                     /description="Methyltransferase domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg2_30_0008"
                     /evalue="1.50E-07"
                     /label="ctg2_30"
                     /locus_tag="ctg2_30"
                     /protein_end="208"
                     /protein_start="149"
                     /score="32.1"
                     /tool="antismash"
                     /translation="VLDLGCGAGTLLHALVADDREFVGWGLDRNPSMCKAARMRARQAG
                     IAARVKVFQGDGRH"
     CDS             complement(9797..10417)
                     /locus_tag="ctg2_31"
                     /transl_table=11
                     /translation="MNWIAFSHGAMLCASLIVTIGAQNAFILRQGIMRSHVGKIVLLCT
                     LSDMLLIGAGVGGASVLVERYPAFVHAVLYVGLAYLAWFGLSALRRAFKPGHETLDATG
                     AVAAPPAQRAWPIVLMTLAFTWLNPHVYLDTFLLIGTAGAREPEGARGAFAIGAMAVSA
                     VWFVALGYGARLLAPWFKRALAWRVLDGAIGGMVLFLAAVQLR"
     PFAM_domain     complement(9809..10378)
                     /aSDomain="LysE"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF01810.20"
                     /description="LysE type translocator"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg2_31_0009"
                     /evalue="1.50E-36"
                     /label="ctg2_31"
                     /locus_tag="ctg2_31"
                     /protein_end="203"
                     /protein_start="13"
                     /score="125.8"
                     /tool="antismash"
                     /translation="ASLIVTIGAQNAFILRQGIMRSHVGKIVLLCTLSDMLLIGAGVGG
                     ASVLVERYPAFVHAVLYVGLAYLAWFGLSALRRAFKPGHETLDATGAVAAPPAQRAWPI
                     VLMTLAFTWLNPHVYLDTFLLIGTAGAREPEGARGAFAIGAMAVSAVWFVALGYGARLL
                     APWFKRALAWRVLDGAIGGMVLFLAAV"
ORIGIN
        1 cggcgaatcg gtgcacgcgg tcgcgttcac gcgattgcac gagcggccga tccgcatcga
       61 ctgacgccga tcggcaggaa tccggatcaa cccggcgttc tcgcctgggc ggcgtcgttc
      121 gtcgagcccg gctcgacatc ggcgccgccg tgcaattcga cgttcccgtt ctgcaactgg
      181 cgcgcggctt cgcgatcgag cgcgctgtct ttgaggatcg cgcacatcgc gacgaacagc
      241 gcgagcgcga ttgcggcgag cccgcaatag ccgacgattt tgagcgttct cggaatgccg
      301 gcgtgggtgt ggtggcgagt catggacgcg tatccgggtg gcgacgcgcg aagccgcgcg
      361 gtctcgttct cgttcgacac gcgaaaatac cgcggtgcgc gccgtgcttt tccctatccg
      421 gtcacggcgg cgcgcgcccc gttgtgccgc catcggcgtc gccatgtgcc gtcgacatag
      481 gtataggaca cgggcgatgc ggatgcaact ccgctcgtgt ggagacgcgc ggatgcgagg
      541 gcatcgcgcg atgcaagcgg acgatggcat ctgaacgcgc gcgccggccg ccgtcgctgc
      601 ggcgttgatc ggcgggaaaa cggcggagaa gcgaacgaaa cggctttgtc ggcgcgcgga
      661 atggcagcga aggcgtgcga tgcgatgggt cagcgcggcg cggctgcgct cgagcggcgc
      721 ggcggtgcgg tgcgatcggg cgcgaaccag agccgcttgc catgagcgac gtatcgcgag
      781 cgtggcggtg cgcggctatt tcaagataat caagacaagc cgatgcgatg cgacagcggt
      841 acgcgcgcga ttcagctcat acgaaacggc gaaaacgcga cgcggcgaac gtagcggcgg
      901 cgtgaagggg tttgcggttt tggctttcgc tttcggcgat ggccggtcga ggcgtacgcg
      961 cgtgtgctgc ctgccggccg ctatcgcgtg cattgcaata ctgcatgcgg gtgccggcga
     1021 cgccgtgcgc ttggatcgcg cgcgtgaatc gccgggcgat attcgcgcgc gcagcggccg
     1081 gccgcggatc agtcttcgag cgattcgtgc acggcgatcg caccgtgctt ccagtaagcg
     1141 gatgcgcgaa tccgcgattt cgcgacgccg cgctcgcggc acagatgctc gcgcacgccg
     1201 cgcatcgcgg ccgcctcgcc cgccgcccat acgtagcctt cgcccgccgg cagcggcagt
     1261 tcgcgcaatg cgtcgaccag ccggctcgcg ccgcgctcgc cgctcgccgc atcgccgcga
     1321 tgtcgccata ccacatacag gttcgcatcg gtttcgaatg cgatctgcgc cgacggatcg
     1381 gccacttcga gcaccgccgc gacgcgcgtg ccggccggca attcctcgag ccggcgcgcg
     1441 acggcgggca atgcggtgtc gtcgccgatc agcagatgcc agtcgaaatc cttcgggatc
     1501 acgaacgaac cgcgcggccc gccgatgccg agcgtttgcc cgacgcgcgc ctgagcggcc
     1561 cactgcgaag ccggccccgg atgatgcagc acgaaatcga gatcgagctc tcgcgcggcg
     1621 cgatcatagc ggcgcggcgt gaaatcgcgt gcgacggggc gcggcctgtc ctgcggaaac
     1681 acgatgccgt tcgggccgaa ttcggggcgc gcgggtgcgt cttcgccggg cggcgggaag
     1741 aagactttca cgtgatcgtc gaacgacgcc gattcgaaat cgtcgagttc gtcgcctgcc
     1801 agcgtcacgc gcttcagatg cggcgtcacg tcgacgacgc gcttgacctg cagcaggcgg
     1861 aatttcagcg tatgacgcac gcgtacgacc gcgcgctcgg tagtcggttg ggtcatgtcg
     1921 atcggttctc cttgatgagc cggaaacggc gcgattcagc cttgcgcgcg gccttcgatg
     1981 tcggcgacgg cgcgccgcaa aatggccgcg atgcggcgtt gctcgtcggc gtttgcaccg
     2041 cttctgcgaa agagcgcttg cttgagcgcc atccgtgctt cgacgaattc cggcagccag
     2101 ccgcgcgtgt cgtcctcggg cgcggcgggc gcttcgccgg cgaacgcgcg acgcatgaat
     2161 tccatcttgc ggccgagatg cgcgagcttc gcgaacagca tctcgacgcg ttcacgctgc
     2221 gcgtcgagat gcgcgcggcc cgcgtcggcg agcgcgtaac gcttgcggtt gccttcggcc
     2281 tgcaccgtca cgtagccgag ttcttccaga tacgtgagcg ccggatacac catgccgggg
     2341 ctcggcgcgt agaagccgct cgagcgcgtg tcgagcgcct tgatcagctc atagccgtgg
     2401 ctcggctgct cggcgagcag cgcgagcagc agcaactgca gatcgtcggc gctgaattga
     2461 cggccgcgcg gcatcgcgtc gtctccgaag ccgccgaacc caccggggcc gccgccgccg
     2521 aagccgccga atgggccgaa gccatgccgg ccgccgccgc ggcgatggcc gccgaacatc
     2581 tgacgaaaca tctcgaacgg gctgtgtccg aacgaatcgg acatgccgca ttcgcggcgc
     2641 gaaaaacggt gagcgtgacg catgtccgcc tcctgtgtct ttagatgtat ctaaagatat
     2701 atatcgaaag atataaagtc aacggaattt aaacggggaa cgagggggcg gagtgcgatg
     2761 gccggacggg cgatgtcccg cccggtaccg acacgcggag ggcgcgacga tgccggaatg
     2821 ccgcgtgcaa gggtggggcg acggcgacgg ccgaaggcgg catggcgaac ccggcccctg
     2881 gcccgttcgt tcgatggcgg atgtttatcc gtcccggggc gtgccgtatt gcgcgacggc
     2941 gttgcgatcg cgctcgggcg gtaccggccg ggcggcttcg gaagacgtga tactgtgacg
     3001 gcagccatgc tgtagcgatc aaccggcgta gccacgatcg gcacgaatcg ttcacggaca
     3061 cagcgcgcaa atgaatggcc tccctctgtc gcttccgcga gtcgacagca ccgattcgct
     3121 ctttgcggat ccgctcgctt ttctcgcacg agcgcgcgcg caatgcggcg acgtcttcgt
     3181 gctgcgggag cacggtccga ttttttctcg cgcgagcgat tgcagcggcg tgatcgccgt
     3241 gttcggcgaa catcggcttc gacaagtctt gaccgagacg gacaccttcg cgctgccgat
     3301 gtcagcggcg gcgaagatgg cgttgccgaa gaatctggtc aacctcaacc gcggcttgca
     3361 cagcatgcgc gagccggagc acggccggca caagcgcctc ctgacgggaa cggccaaccg
     3421 cgcgctgttc gacgcgcatc gatccggaat gcaaacggat ttgagccgct tttgcgaaat
     3481 gctgaacggg gacggccgga tttccgtcgt gagccgaatg cgcgagctga cagccaagtt
     3541 ggcgtcccgt ctttttcttg ggccgcagtg tgaggaggat gccgaactga cgtttctgct
     3601 aagcgcgtat ttcacgttgc ggcgcgaggc gtcttcgccc aacgcgcacg atccgttgca
     3661 gtaccgggac gcgctgatcg gcgccgggcg gcaactcgat cgcgcgttgc gggcgcggat
     3721 ccggcggtat cgaaaggcgc ccgccggcga gtgcgcgggg ctgctccagc ggctggcgac
     3781 ggccggccag ccgggttcgc ccgcgctttc cgaggatgag atcgtcggcc acgccaacgt
     3841 gatgtttgtg tcgagcacgg agccggtggc gatatcgctg gcgtggctgc tgctcgttct
     3901 gtcgcagttg cccgatctgc ggcgtgcgct tcgcgcggaa agcgccgccc gcgcatcgtc
     3961 gccggcttcg ccgtacgacg cgccattgct cgagcgcgtc atcaacgaga cgcttcggct
     4021 cctgacgccc aacgcgctga tggtccgcgc cacgacgcag gcggtttcgt tgcaaggcgt
     4081 cgcgcttccc gcgcgctgcg agattgtcgt gtgcccgttc ctcgtgcacc gcgaggccaa
     4141 cgcgtttgcg cgcccgcatg cattcttgcc gtcccgatgg gagacggcga ggccgtcgcc
     4201 gtacgagtat tttccattcg gcgccggcgg ccatttctgc gcggggcgga atctcgcgct
     4261 gtcgctgatt ggcgaagtgc tgtcgacgct gctatcgcga ttcgatttcg ttttggatat
     4321 cgaacagttt atcgactggc gcattcatat catgctgatg ccgaaaggcg acccgacgct
     4381 cacggcgcac cccgtcgatg aacgccgcga cacgccgtcg ccgaaatggc gcgggcctgt
     4441 cgccgagctg ttccatttcg cgccggggct ttcttgacat ttaccggggc gcatccttta
     4501 atcagaagca aatcggcatg cacacccgac gggatttttt cggtcatcga ttcgcatggc
     4561 gattttcggg ggttattccg cactcacagc tgagcgttgc gtcctgccca caacaaagga
     4621 acgatcatgg ccacgaaacc caaaaaaaca aagggcgttt ccgtttccat cgaagggaag
     4681 ctgcccaaga tgacgctgga tatgccggtg gacgcgaaaa agatcaaggc catccagaaa
     4741 tgcctggaaa acggcaagct gacgatcacg atgagcaagg tggatctcgc cggcggccgc
     4801 atgggcgagg gctatctcta cgactgacgt ccggcggcgc gcgcgggcct tgccggccgc
     4861 gccgcattct cgtcgcctcg atgctcgggc ttcgcagaga agccgcgccg ccgaacgcga
     4921 ggcgttcggc gtgcgctcgc gcaatggcgg gcgataaatc tggactgctg cggttcggcg
     4981 cctgaaggcg cgggaagcct atgaaagcgt tcgatcgcga tgccggggcg ccccggatcg
     5041 gccttgcgta cgggcccggc atggcggaat tcgccgcacg gcatgcgcat ctcgtcgatt
     5101 acatcgaagt gccgttcgag ctcttgcgat tctcgccgac gattgccgag cttcagcaaa
     5161 ccattccgtt cgttctgcac tgcgccagct tgtccgttgc gggattcgtg ccgcccgacg
     5221 attcgaccgt cgacgcaatc gagcgcacgg ccgtgcgcac cggcacgccg tggatcggcg
     5281 aacatctcgc gtacatctcg gccgatccca tcggcgaggc gctgggtggg acccatgagc
     5341 ccacgtcgct gtcttacacg ctgtgccctc agttgagcga cgagacggtg cggcgcgtcg
     5401 ccgataatct cgccgtgctc gctccgcgct ttccggttcc gctgatcgtg gaaaattcgc
     5461 cccaatactt ttcgattccc ggcagcacga tgggcatgac cgacttcatt cgcgcgatcg
     5521 cggaccggtg cgatgtcggc ttgctcctgg atctgagcca ttttctgatc acggcgtaca
     5581 acacgggcgc cgacgtgcac cgggaattcg cccggctgcc gctcgagcgc gtggtcgaag
     5641 ttcacctgtc cggcatgagc atccagtccg gcgcggcctg ggacgatcat tcgctgccgg
     5701 cgtcgccgat cctcttcgaa ctgctcgagc gcctgctcgc cgtcgcgcgg cctcgcgcgc
     5761 tgaccttcga atacaactgg tcgccatact tcccgttgtc ggtcctcacg agccacatcg
     5821 aacgcgcgcg cgcgctgatg gggcttgcat gaacgcaagg acgatacacg cgctgatcgc
     5881 ggccagcacc aaggatccgc agctcatcga gcgttggcgg cggcatccgg acctgctgcg
     5941 cggcgcgggc atcgcgcccg gcgatctcga ttggcgcgca ttggagcatt tcgtcgggtt
     6001 gagcctgaag gtgcgccaca acggcctgcg cggagatttt ccgctgagct tcaggctgct
     6061 gagcgtggtc ggcctcgaga tcgaggtatt cgccgcgtat gcgtcggact gcgcggagag
     6121 cggccacgta ttcgccgcca cgccgcagga gcgcgcgcgc gatctgattg cgtttctcga
     6181 tagatggctc gatcccgcgc aacgcaatca cgttctgctg tgggacatcc tgcgccatga
     6241 atacgcgctc gcatgcctgc ggcaagcggg cgacgcgccg cttgccgatg cgcgtcccgc
     6301 cgcgcgtcat cgggcgcgcg cgacggccgg cggcattccg acgctcaacg gctccgtcgt
     6361 tcaacacgtg atgcgctgca atcctgacga tctggcggcg gcgcttcatc agaaggagcc
     6421 gccgctcgac gcggttcccg ccgtcgacac ttactgctgc tattggcgct ccgccgaaac
     6481 gggcgaaata cggttgctgc gggtcgatac gctcggttac ttcgcgatcg aagcgatcga
     6541 cggcaggcgg tccgccgccg acatctgcca tcggttgctc ggcaatcgcc gtctgctgcc
     6601 gcagttcctg agttcgctcg accaactggc cggcatcggg atcgtgcgat tcgcgcggcc
     6661 gctcggatgc gccgcggcat gaagctgctg ctcgtcgaca atctcgtcat gccggaagag
     6721 ggctcgctcg cctatctcga cgtgcatccg catctcgggc tgctcgcgct ggccgcggtc
     6781 gccgaggccg acggccatcg cgtgcggatc tatgatccga agcgactgat ccgggacggc
     6841 acgctcgctt acgatgcgac gctttacgag cgggcgagcc gcgcgatcct cgccgagcgc
     6901 ccggacgcgg tcggcttcac cgcgctcggc tgcagttttc tgttcgcgct caatgtcgcg
     6961 gcgctgctga agcggcgcga gcccgatttg ccggtcctgc tcggcggccc gcacgcgacg
     7021 atgctgcatc ggcagatcct cgagcgattc ccgcagttcg acatcatcgt tcgctacgaa
     7081 gcggacgaga tccttcccgc cgtgctcgac tgcctcgagc agcggacatt cgatgttatc
     7141 cccggcttga gctggcgcgc gacgggccgc ggtgcgccgt tgcgcttcac cgacggcaag
     7201 cccaaggtcg aggaactgga ccggctgccg atcgcgtcgt acgaccatta tccggtcgac
     7261 gatctgggct tctcgatgct gcgcatcgag gccggccgcg gctgtccgtt cgcatgcacg
     7321 ttctgttcga cggcgggctt ctttcagcgc agctttcgcc tcaagtccgc cgagcgcctg
     7381 gtgcacgagc tggacatcct tcatcggcgc tatcgcgtgt ccgacttcaa gctcgaccat
     7441 gacatgttta ccgtgaatcg ccacaaggtg atggcgtttt gcgaggcggt ggccgggcgc
     7501 ggctaccggt ggcgcgcgtc ggcgcggatc gattgcgtcg acgaagcatt gctgaggaag
     7561 atggccgacg cgggctgcgt gaatctttat ttcggcgtgg agaccggctc cgaacgcatg
     7621 cagacaatct gccggaagcg gttggacttg cggttggtcg agcccattct ggccgcggcg
     7681 gattcgttcg gaatcgagac gaccgcgtcg ttcatcaccg gctatccgca ggaaagcggg
     7741 caggaccagg acgacacgct ggacatgatc gggcgctgcg cgcggcggcc gtcctgcctg
     7801 acgcaactgc acatgctcgc gccggagccc ggcacgccgc tgttcgacga acacggggcg
     7861 cagatcgcct acgacggcta tggcgggcct tacaacacgc gcctgctggg cccggaggac
     7921 gagcgcgagg tgctcgacca tcccgacata tttcaaacct actattacta tcccgccgcg
     7981 ctgccgcgcg cgagacacat ctttgccgtc gaggcggtgg atgtgctgcg ccgcgcgggg
     8041 ccgatcatcc tcgcgtacgc tttgcgggaa ttcggcggac ggctgagccg gctgatatcg
     8101 gcatggcgac ggttcgcgga cgaaacgtcg cccggcgcgt tgccggatgc ggcggggctg
     8161 gaggctttcg tggccgcgcg attcggccgc ggccatcacc tgcattctct tttccggtac
     8221 gcgttgcggc tgtccgcggc ccgcgctccg gcggacgtcg tcgccgaagg gccctatgag
     8281 ccggaccggc cttgcatgct ggccgaaaac gtcggcctgc tggaggacat ccacaattgc
     8341 gaggcgttgg tcgatcggct ccggcgctcg aacgacggtg cgccggcgct cggcgacgcg
     8401 gatgtcggcg ggctcggcgc ctatatcgtc cgcgcggacg gcgaagccgt caccggctat
     8461 tgggtggagt ccggcattgc cgcgatcctc gatctgttca gggcgccccg ttcgtgccgc
     8521 gccgctgcgc aatggctggc gcacgtcacc cgcaatgacg gcgtggacgc ttcgatcttc
     8581 gagctgctgc tgcgcagagg cattttggtg ccggcccgct aaattcattt cgctcatggc
     8641 tcgtcggaaa ctcgaacgct ggtccgcgct ggatctcgcg gaaggtcttc aactggcgca
     8701 tgccgtcgcc gcgctgcaaa cgctcggcgt cgtggatgcg atggcggagc cgacgacggc
     8761 gcaaacgctg agcgccgcgt gcgatctcga tcccgagttg ttgcgaggcg tcctcgaata
     8821 cgcggcatcg agaacgaacc tgatccgcaa gaccggcgac cgattcgcgg cttccgagca
     8881 ctacacggcg caagcgcgtt tcctgctgaa cctgtatgcc ggcgcctatg ccgataacgc
     8941 ttcgcggctg gcgacgctgc tccggcggcc ggcgctggcg ggcacgacgg tcgacctcgt
     9001 cgcgcacgcg cgcgccttcg aggcgagcga ggcgggcggc ggggcgctcg ccgcgatcat
     9061 cagccaattg cacctgaatc acgtactgga tctcggatgc ggcgccggta cgctgctgca
     9121 cgcgctggtg gcggacgatc gtgaattcgt cgggtggggg ctggatcgca atccgtcgat
     9181 gtgcaaggcc gcccggatgc gggcgaggca agcgggaatc gcggcgcgcg tgaaggtgtt
     9241 tcagggcgac ggcaggcatc ccggcgcgtc gattccgccg cgcgtgctgg cgcgcgtgcg
     9301 caacgtcgtc gcgagccagt tcgtcaacga gatgtttcgc ggcggcacgt cccgcgcgca
     9361 ggcctggctt cgacgcatgc gccgcctgct gcccgaccgc ctgctcgtga tcgcggacta
     9421 ctacggccgc ctcggccacg gttttcaaac gccgcaccgc gagacgctgc tgcacgacta
     9481 tgcgcagctc atatcggggc aaggcgtgcc gccgcccaat gccgacgcgt ggctcgccat
     9541 gtatcgggcg gccggttgcc ggcctctgca tgtgatcgaa gaccgcgcgg ccacgacgcg
     9601 cttcgtccac ctggtagcgc tgtagcggca tgacgggcgc ggctcggcgg cgccgcttgc
     9661 gccgaccgcg tgcgccggct ggccgattcc ctcggggcgt gcggccatga cgttcgtggc
     9721 tcgctcgccg ccgtgcgccg cgtgccgccg tccgcgcttc agatggcgtc ggcaccgcca
     9781 acgcgcatcc gccgcgttag cgcaactgca ccgccgcgag aaacagcacc atgccgccga
     9841 tcgcgccgtc gagcacgcgc cacgcgagcg cgcgcttgaa ccatggcgcg agcaatcgcg
     9901 caccgtatcc gagcgcgacg aaccataccg cgctgaccgc catcgcgccg atcgcgaacg
     9961 cgccgcgcgc gccttccggc tcgcgcgcgc cggccgtgcc gatcagcagg aacgtgtcca
    10021 gatagacgtg cgggttgagc catgtgaacg cgagcgtcat cagcacgatc ggccaggcgc
    10081 gctgcgcggg cggcgcggca accgcgcccg tcgcatcgag cgtttcgtgg ccgggcttga
    10141 acgcgcggcg cagcgcgctc aggccgaacc atgcgagata ggcgaggccg acatacagca
    10201 cggcatgaac gaaggccgga tagcgctcga cgagcaccga tgcgccgccg acgcccgcgc
    10261 cgatcaacag catgtccgac agcgtgcaga gcaggacgat cttgccgacg tgcgaacgca
    10321 tgatgccctg ccggaggatg aacgcattct gcgcgccgat ggtgacgatg agcgatgcgc
    10381 agagcatcgc gccgtgagaa aaagcgatcc agttcatgtt cgttgcggct tccggcggtg
    10441 gactaacggg gcaagaggcg ctagtctgcg atgatcgctt gagtaagaaa agctaaatga
    10501 tctaatgccg attaaggaaa actgatgctc gactatgcac tgctcgatgc gcttgccgaa
    10561 gtgatccgcc acggctcgtt cgagcgggcg gcgaaagcgc tcaacgtgtc gccttcggcg
    10621 gtgtcgcagc gcgtgaagct cttggaggag cgcgtgggca gcgtgctcgt gaagcgcggg
    10681 cagccgtgcg tcgcgacgac ctcgggcgcg ctgctgtgcc gccacaccga gcgcgtgcgg
    10741 atgctggagg ccgagctgtc cgggcacatg cccgcgttcg cgggcgcgca agcggcggcg
    10801 tggccgacgc tgcgcgtggc cgtcaacgac gacagcgtcg cgacctggtt cg
//
