LOCUS       NZ_CP065054.1           9272 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  NZ_CP065054.1 Streptococcus equi subsp. zooepidemicus strain SEZ13
            chromosome, complete genome.
ACCESSION   NZ_CP065054
VERSION     NZ_CP065054.1
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 6.1.1
            Run date     :: 2024-03-14 14:56:30
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 130211
            Orig. end    :: 139483
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     CDS             1..324
                     /locus_tag="ctg1_116"
                     /transl_table=11
                     /translation="MKMRLSTLKDQAVQAFTLLEMLLVLLIISVLMLLFVPNLSKQKDK
                     VTDTGNAAVVKLVENQAELYELSHGEKPSLKQLQEDGSISDKQQKAYQDYYAKHKDETK
                     KLN"
     protocluster    1..9272
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[135030:135282](-)"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193)"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(4820..5071)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193)"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
     cand_cluster    1..9272
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193)"
                     /kind="single"
                     /product="RiPP-like"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..9272
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="RiPP-like"
                     /region_number="1"
                     /rules="(strepbact or Antimicrobial14 or Bacteriocin_IId or
                     BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or
                     Lactococcin or Antimicrobial17 or Lactococcin_972 or
                     Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or
                     TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or
                     TIGR03975 or DUF692 or TIGR01193)"
                     /tool="antismash"
     PFAM_domain     40..102
                     /aSDomain="N_methyl"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF07963.14"
                     /description="Prokaryotic N-terminal methylation motif"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_116_0001"
                     /evalue="2.20E-04"
                     /label="ctg1_116"
                     /locus_tag="ctg1_116"
                     /protein_end="34"
                     /protein_start="13"
                     /score="20.8"
                     /tool="antismash"
                     /translation="QAFTLLEMLLVLLIISVLMLL"
     aSDomain        43..102
                     /aSDomain="TIGR02532"
                     /aSTool="tigrfam"
                     /description="IV_pilin_GFxxxE: prepilin-type N-terminal
                     cleavage/methylation domain"
                     /detection="hmmscan"
                     /domain_id="TIGRFam_ctg1_116_0001"
                     /evalue="5.50E-05"
                     /identifier="TIGR02532"
                     /label="ctg1_116"
                     /locus_tag="ctg1_116"
                     /protein_end="34"
                     /protein_start="14"
                     /score="20.9"
                     /tool="antismash"
                     /translation="AFTLLEMLLVLLIISVLMLL"
     CDS             287..727
                     /locus_tag="ctg1_117"
                     /transl_table=11
                     /translation="MQSIKMKLRSSIKAFTLLEGLLTLFLISFMLLCLSLPVSDSYARV
                     EEHLFFMRFEQAYRHLQKLSILRQKEHVLVLKPHYIKAEEAILPLPKQVKLKSTQTLTI
                     DKLGGNHSLARVVFENRDRQITYQFYLGSGNYQKTSQSLHRS"
     CDS             684..974
                     /locus_tag="ctg1_118"
                     /transl_table=11
                     /translation="VVIIKKQVKAYIALEGLIATGLILVIVTLILSALHYSQQELAACR
                     QKQELLNTAVMAMQTKQRVLSLNGCHIKLLSHQKGIAIVEKDQTIIRIERQ"
     PFAM_domain     717..962
                     /aSDomain="PulG"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF11773.10"
                     /description="Type II secretory pathway pseudopilin"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_118_0002"
                     /evalue="4.20E-24"
                     /label="ctg1_118"
                     /locus_tag="ctg1_118"
                     /protein_end="93"
                     /protein_start="11"
                     /score="84.3"
                     /tool="antismash"
                     /translation="IALEGLIATGLILVIVTLILSALHYSQQELAACRQKQELLNTAVM
                     AMQTKQRVLSLNGCHIKLLSHQKGIAIVEKDQTIIRI"
     CDS             931..1395
                     /locus_tag="ctg1_119"
                     /transl_table=11
                     /translation="LLKKTKRLLGLKDSRLKAFTLIECLIALLVISGSLLVYQALTKSL
                     MVSERYLAANDQDNWLLFSQQLRAELSGTTLQGVSNNRLYVEKDKKTLSFGQVKSHDFR
                     KAAGNGRGYQPMLFGLSSSQITAVGQQVIIKLKWQSGLERTFIYAFQEKG"
     aSDomain        982..1029
                     /aSDomain="TIGR02532"
                     /aSTool="tigrfam"
                     /description="IV_pilin_GFxxxE: prepilin-type N-terminal
                     cleavage/methylation domain"
                     /detection="hmmscan"
                     /domain_id="TIGRFam_ctg1_119_0002"
                     /evalue="2.30E-04"
                     /identifier="TIGR02532"
                     /label="ctg1_119"
                     /locus_tag="ctg1_119"
                     /protein_end="33"
                     /protein_start="17"
                     /score="18.9"
                     /tool="antismash"
                     /translation="AFTLIECLIALLVISG"
     PFAM_domain     1081..1359
                     /aSDomain="ComGF"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF15980.7"
                     /description="Putative Competence protein ComGF"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_119_0003"
                     /evalue="1.00E-18"
                     /label="ctg1_119"
                     /locus_tag="ctg1_119"
                     /protein_end="143"
                     /protein_start="50"
                     /score="67.6"
                     /tool="antismash"
                     /translation="YLAANDQDNWLLFSQQLRAELSGTTLQGVSNNRLYVEKDKKTLSF
                     GQVKSHDFRKAAGNGRGYQPMLFGLSSSQITAVGQQVIIKLKWQSGLE"
     CDS             1373..1735
                     /locus_tag="ctg1_120"
                     /transl_table=11
                     /translation="MHFKRRVKAGVLLYALLMASVFLLLLQAYLSHISQLHQEYQAQMD
                     YAKAQLMAEMVYQEQPPSDGQIAFNCGQASYKSHKQHFIIEIKLPHQQLYQFSYPKVQQ
                     VSQTSKKEPELRQSLP"
     CDS             1797..2750
                     /locus_tag="ctg1_121"
                     /transl_table=11
                     /translation="MNFEKIEQAYELILENSQLIENDLKTHIYDAIVEQNSFYLGAQGA
                     SPQVAKNIETLKALQLTKEEWRQAYQFVLIKAGKTEPLQANHQFTPDAIGFIMLYILET
                     LSSQESLDVLEIGSGTGNLAHTILNHSHQAIHYLGIELDDLLIDLSASIAEIMGSSAQF
                     IQEDAVRPQLLKESDMIISDLPVGFYPNDDIASRYQVASSDEHTYAHHLLMEQALKYLK
                     KDGFAIFLAPVNLLSSPQSHLLKQWLKGYAQVAALITLPEAVFGNPANAKSIIVLCKQS
                     NRFAETFVYPIRDLKSVDNVRDFMENFKNWKRDNVI"
     PFAM_domain     1998..2678
                     /aSDomain="N6_Mtase"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF02384.18"
                     /description="N-6 DNA Methylase"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_121_0004"
                     /evalue="1.50E-07"
                     /label="ctg1_121"
                     /locus_tag="ctg1_121"
                     /protein_end="294"
                     /protein_start="67"
                     /score="31.1"
                     /tool="antismash"
                     /translation="QAYQFVLIKAGKTEPLQANHQFTPDAIGFIMLYILETLSSQESLD
                     VLEIGSGTGNLAHTILNHSHQAIHYLGIELDDLLIDLSASIAEIMGSSAQFIQEDAVRP
                     QLLKESDMIISDLPVGFYPNDDIASRYQVASSDEHTYAHHLLMEQALKYLKKDGFAIFL
                     APVNLLSSPQSHLLKQWLKGYAQVAALITLPEAVFGNPANAKSIIVLCKQSNRFAETFV
                     YPIRD"
     CDS             2810..4009
                     /locus_tag="ctg1_122"
                     /transl_table=11
                     /translation="MSKTIAINAGSSSLKWQLYQMPEEKVLAQGIIERIGLTDSISTVK
                     FDGKKEEHILDIPDHTEAVKRLLNDLIHFGIIGTYDEITGVGHRIVAGGEYFKESVVVD
                     DKVVEQVEELAALAPLHNPGAAAGIRAFRKILPDITSVCVFDTSFHTTMQKHTYLYPIP
                     QKYYTDYKVRKYGAHGTSHKYVAEEAAKMLGRPLDELKLITAHVGNGVSITANYHGQSV
                     DTSMGFTPLAGPMMGTRSGDIDPAIIPYLIAQDPELKDAADVVNMLNKQSGLGGVSGIS
                     SDMRDIEAGLQANNPDAVLAYNIFIDRIKKFIGQYFAVLNGADALVFTAGMGENAPLMR
                     QDVVNGLSWFGMEIDPEKNVFGYRGDISTAASKVKVLVISTDEELCIARDVERLKQTIS
                     "
     aSDomain        2813..3994
                     /aSDomain="TIGR00016"
                     /aSTool="tigrfam"
                     /description="ackA: acetate kinase"
                     /detection="hmmscan"
                     /domain_id="TIGRFam_ctg1_122_0003"
                     /evalue="9.80E-150"
                     /identifier="TIGR00016"
                     /label="ctg1_122"
                     /locus_tag="ctg1_122"
                     /protein_end="395"
                     /protein_start="1"
                     /score="496.7"
                     /tool="antismash"
                     /translation="SKTIAINAGSSSLKWQLYQMPEEKVLAQGIIERIGLTDSISTVKF
                     DGKKEEHILDIPDHTEAVKRLLNDLIHFGIIGTYDEITGVGHRIVAGGEYFKESVVVDD
                     KVVEQVEELAALAPLHNPGAAAGIRAFRKILPDITSVCVFDTSFHTTMQKHTYLYPIPQ
                     KYYTDYKVRKYGAHGTSHKYVAEEAAKMLGRPLDELKLITAHVGNGVSITANYHGQSVD
                     TSMGFTPLAGPMMGTRSGDIDPAIIPYLIAQDPELKDAADVVNMLNKQSGLGGVSGISS
                     DMRDIEAGLQANNPDAVLAYNIFIDRIKKFIGQYFAVLNGADALVFTAGMGENAPLMRQ
                     DVVNGLSWFGMEIDPEKNVFGYRGDISTAASKVKVLVISTDEELCIARDVERLK"
     PFAM_domain     2819..3976
                     /aSDomain="Acetate_kinase"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00871.19"
                     /description="Acetokinase family"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_122_0005"
                     /evalue="2.50E-148"
                     /label="ctg1_122"
                     /locus_tag="ctg1_122"
                     /protein_end="389"
                     /protein_start="3"
                     /score="494.0"
                     /tool="antismash"
                     /translation="TIAINAGSSSLKWQLYQMPEEKVLAQGIIERIGLTDSISTVKFDG
                     KKEEHILDIPDHTEAVKRLLNDLIHFGIIGTYDEITGVGHRIVAGGEYFKESVVVDDKV
                     VEQVEELAALAPLHNPGAAAGIRAFRKILPDITSVCVFDTSFHTTMQKHTYLYPIPQKY
                     YTDYKVRKYGAHGTSHKYVAEEAAKMLGRPLDELKLITAHVGNGVSITANYHGQSVDTS
                     MGFTPLAGPMMGTRSGDIDPAIIPYLIAQDPELKDAADVVNMLNKQSGLGGVSGISSDM
                     RDIEAGLQANNPDAVLAYNIFIDRIKKFIGQYFAVLNGADALVFTAGMGENAPLMRQDV
                     VNGLSWFGMEIDPEKNVFGYRGDISTAASKVKVLVISTDEELCIAR"
     CDS             complement(4620..4802)
                     /locus_tag="ctg1_123"
                     /transl_table=11
                     /translation="MNNFLELQDQALTNVYGGGGNIGSAIGGCIGGVLLAAAGGPITGG
                     AAAFVCIASGIATGL"
     aSDomain        complement(4659..4793)
                     /aSDomain="TIGR03949"
                     /aSTool="tigrfam"
                     /description="bact_IIb_cerein: class IIb bacteriocin,
                     lactobin A/cerein 7B family"
                     /detection="hmmscan"
                     /domain_id="TIGRFam_ctg1_123_0004"
                     /evalue="4.00E-11"
                     /identifier="TIGR03949"
                     /label="ctg1_123"
                     /locus_tag="ctg1_123"
                     /protein_end="48"
                     /protein_start="3"
                     /score="40.5"
                     /tool="antismash"
                     /translation="FLELQDQALTNVYGGGGNIGSAIGGCIGGVLLAAAGGPITGGAAA
                     "
     CDS             complement(4820..5071)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: Bacteriocin_IIc"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg1_124"
                     /sec_met_domain="Bacteriocin_IIc (E-value: 6.2e-16,
                     bitscore: 55.4, seeds: 35, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MFKRSKKLTSEELADIIGGYNATDCRNHLIGGISGGAITGGVGSG
                     LVTLGVGGPAGAFVGAHIGAIAGGITCIGGMIGNNIKF"
     PFAM_domain     complement(4886..5062)
                     /aSDomain="Bacteriocin_IIc"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF10439.11"
                     /description="Bacteriocin class II with double-glycine
                     leader peptide"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_124_0006"
                     /evalue="1.90E-09"
                     /label="ctg1_124"
                     /locus_tag="ctg1_124"
                     /protein_end="62"
                     /protein_start="3"
                     /score="37.5"
                     /tool="antismash"
                     /translation="RSKKLTSEELADIIGGYNATDCRNHLIGGISGGAITGGVGSGLVT
                     LGVGGPAGAFVGAH"
     CDS             5585..7627
                     /locus_tag="ctg1_125"
                     /transl_table=11
                     /translation="MVDSKAVVILMTLMTYQDLSLYELSVKTKFTIREIKDRIDELNDF
                     LAQHELSELQTTRSGYRISQQLKAESDHLFTLINAEQVYLSQAERINLIYLYTFCRRDF
                     VSNSHYQDFLKVSKNTALTDIKALRQKLADVDLELRYTRASGYTLVGDELDKHRLALAM
                     IATLLKSPIGLWALDYILASWHYQVSFEALEKRVSHFYQTFQMSPILDRLQACLYAFIF
                     ILCRYQRRVDRVKQRPVVVSEQLDQLTALLVSEIMQQLSLRYQLFEADEAYFQLLLAGC
                     FEGEGTVSDDFFESLTAAIVDQMQGVALLSFSQSDQLKEDLKRHLIPAYYRLRYGLPSD
                     NDYTLRVKDSYSELFDLVKQSLEPLAKELDSPIPDSEIAYFVLHFGGYLKQQGKDFHRQ
                     AYRAVIVCPNGVSSSLMIKEHLKLLFPDIAFRGLSRLDQLGQLDESGYDLVFSTIRLET
                     DKPFYLVPMIMTDEQAFQLVSLVNRDFPDIGYRLEVEELLHLISSYAVIHQKEKLRFAL
                     QQYLRQDVKRKDIRPVLQDLITKKTYQSTSEQLGWREAIYLAAQPLLESGQIQASYQEA
                     MIAKVEEFGPFINLGKGIAIPHARPEDGVNQVGMSMLVLEHPIYLLDDPKQEIRLLICI
                     AAIDNETHLKALSRLTTILRDNEQVKALLASKSFEDIKTIIAEEA"
     PFAM_domain     6482..6745
                     /aSDomain="PRD"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00874.22"
                     /description="PRD domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_125_0007"
                     /evalue="8.00E-18"
                     /label="ctg1_125"
                     /locus_tag="ctg1_125"
                     /protein_end="387"
                     /protein_start="299"
                     /score="64.6"
                     /tool="antismash"
                     /translation="IVDQMQGVALLSFSQSDQLKEDLKRHLIPAYYRLRYGLPSDNDYT
                     LRVKDSYSELFDLVKQSLEPLAKELDSPIPDSEIAYFVLHFGG"
     PFAM_domain     7214..7618
                     /aSDomain="PTS_EIIA_2"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00359.24"
                     /description="Phosphoenolpyruvate-dependent sugar
                     phosphotransferase system, EIIA 2"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_125_0008"
                     /evalue="2.90E-30"
                     /label="ctg1_125"
                     /locus_tag="ctg1_125"
                     /protein_end="678"
                     /protein_start="543"
                     /score="105.1"
                     /tool="antismash"
                     /translation="QSTSEQLGWREAIYLAAQPLLESGQIQASYQEAMIAKVEEFGPFI
                     NLGKGIAIPHARPEDGVNQVGMSMLVLEHPIYLLDDPKQEIRLLICIAAIDNETHLKAL
                     SRLTTILRDNEQVKALLASKSFEDIKTIIAE"
     CDS             7629..7916
                     /locus_tag="ctg1_126"
                     /transl_table=11
                     /translation="MALRIGTACGSGLGSSFMVQMNIESVLKDLGVTGVEVEHYDLGGA
                     DPTAADVWIVGRDLADSAGHLGDVRILNSIIDMDELTSLVKAICQEKGLV"
     PFAM_domain     7641..7874
                     /aSDomain="PTS_IIB"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF02302.19"
                     /description="PTS system, Lactose/Cellobiose specific IIB
                     subunit"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_126_0009"
                     /evalue="8.60E-12"
                     /label="ctg1_126"
                     /locus_tag="ctg1_126"
                     /protein_end="82"
                     /protein_start="4"
                     /score="45.7"
                     /tool="antismash"
                     /translation="IGTACGSGLGSSFMVQMNIESVLKDLGVTGVEVEHYDLGGADPTA
                     ADVWIVGRDLADSAGHLGDVRILNSIIDMDELT"
     CDS             7929..9272
                     /locus_tag="ctg1_127"
                     /transl_table=11
                     /translation="MTFLLDIVSTPAILVALIAIVGLLLQKKPAPDIVKGGIKTFVGFL
                     VVSGGAGIVQGSLNPFGTMFEHAFHLSGVVPNNEAIVAVALTTYGSATALIMFTGMIFN
                     ILIARFTRFKYIFLTGHHTLYMACMIAVIMSVAGFTSVSLIVFGGLALGIIMSISPALV
                     QRYMIQLTGHDKVALGHFSSLGYWLSGFVGGLVGDKTKSTEDINFPKSLAFLRDSTVSI
                     TLSMAIIYLIVAIFAGPAWISKELSSGTHGLVFALQLAGQFAAGVFVILAGVRLILGEI
                     VPAFKGISEKLVPHSKPALDCPIVYPYAPNAVLIGFVSSFIGGLVSMAVMIASGTTVIL
                     PGVVPHFFCGATAGVIGNASGGVRGATVGAFLQGVLISYLPIFLMPVLGGLGFEGSTFS
                     DADFGLSGILLGTLRQMGGVTAIVIGIFVILAGLVGLSVVGKSAAKEE"
     PFAM_domain     7947..9134
                     /aSDomain="EIIC-GAT"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF03611.16"
                     /description="PTS system sugar-specific permease component"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_127_0010"
                     /evalue="1.40E-144"
                     /label="ctg1_127"
                     /locus_tag="ctg1_127"
                     /protein_end="402"
                     /protein_start="6"
                     /score="482.2"
                     /tool="antismash"
                     /translation="IVSTPAILVALIAIVGLLLQKKPAPDIVKGGIKTFVGFLVVSGGA
                     GIVQGSLNPFGTMFEHAFHLSGVVPNNEAIVAVALTTYGSATALIMFTGMIFNILIARF
                     TRFKYIFLTGHHTLYMACMIAVIMSVAGFTSVSLIVFGGLALGIIMSISPALVQRYMIQ
                     LTGHDKVALGHFSSLGYWLSGFVGGLVGDKTKSTEDINFPKSLAFLRDSTVSITLSMAI
                     IYLIVAIFAGPAWISKELSSGTHGLVFALQLAGQFAAGVFVILAGVRLILGEIVPAFKG
                     ISEKLVPHSKPALDCPIVYPYAPNAVLIGFVSSFIGGLVSMAVMIASGTTVILPGVVPH
                     FFCGATAGVIGNASGGVRGATVGAFLQGVLISYLPIFLMPVLGGLGFEGSTFSDAD"
ORIGIN
        1 atgaaaatga gattatcaac cttaaaagat caagctgttc aggccttcac tttactggaa
       61 atgcttctgg ttttgttaat cattagtgtt ttgatgctgt tatttgttcc aaatttaagt
      121 aaacaaaagg ataaggtgac agatacaggc aatgctgcgg tggtaaagct agttgaaaat
      181 caggcagagc tttatgaatt atcacatggg gaaaagccaa gcctgaagca actgcaagag
      241 gatggaagca tcagtgacaa gcaacaaaag gcttatcagg attattatgc aaagcataaa
      301 gatgaaacta agaagctcaa ttaaagcttt taccctctta gagggcttac tgacgctttt
      361 tttgattagc tttatgctgc tgtgcttgtc attaccggta tcagatagct atgctagggt
      421 tgaggagcat ctctttttca tgcgctttga acaggcctat aggcacctac agaagctatc
      481 gatattacgt caaaaagagc atgtgctggt cttaaagcca cattatatta aggccgaaga
      541 agctattttg cctctgccaa agcaggtcaa gctaaaatct acccagacct taaccattga
      601 taaactgggc ggcaatcatt cgctggcaag ggttgtcttt gaaaatagag atcggcagat
      661 tacttatcaa ttttatttag ggagtggtaa ttatcaaaaa acaagtcaaa gcctacatcg
      721 ctcttgaagg cttgatagca acaggactta ttcttgttat tgtaacactg atcctgtcag
      781 ccctgcatta tagccagcaa gagctagcag cctgtcgtca aaagcaagag ctattgaata
      841 cagctgtgat ggctatgcag acaaaacaaa gggtattaag ccttaatggt tgtcatatta
      901 agctattatc acatcagaag ggtatcgcta ttgttgaaaa agaccaaacg attattagga
      961 ttgaaagaca gtaggttaaa ggctttcacc ttgatagagt gccttattgc cttgcttgtc
     1021 atctcaggct ctttattagt ttatcaggcc ttaaccaaga gccttatggt gagtgagagg
     1081 tatctagcag caaatgatca ggacaactgg cttttgtttt cccagcaatt gcgagcagag
     1141 ctttcaggta ctaccttaca gggtgtctcc aataataggc tatatgttga gaaagacaag
     1201 aaaactctgt cctttggaca ggtcaaaagc catgatttta gaaaagcagc tggcaatggt
     1261 cgaggctatc agcccatgct gtttggcttg tcaagtagcc aaataacagc agtaggtcag
     1321 caggttatca tcaagctgaa gtggcaaagc ggcttagaaa ggacctttat ttatgcattt
     1381 caagagaagg gttaaggcag gagtgctttt gtatgctttg ctgatggcat cagtcttttt
     1441 attactgtta caggcttatc ttagtcatat tagccagcta catcaggaat atcaggctca
     1501 gatggactac gcaaaggctc agctaatggc agaaatggtc tatcaggagc agcctcctag
     1561 tgatggtcag attgccttta attgtggtca ggctagctat aagtcgcata agcagcattt
     1621 tataattgag atcaaattac cacatcagca gttatatcaa ttcagctatc ctaaagttca
     1681 gcaggtctct cagacttcta aaaaggagcc tgagcttagg caatcactcc cataactaag
     1741 ggagcctggc tagtggtatt cttttcattt cagccttatt ttgatatgat agacgtatga
     1801 attttgaaaa gattgaacaa gcctatgagc ttatattaga aaatagccag ctgattgaaa
     1861 atgatctaaa aacgcatatc tatgatgcta ttgttgagca gaattctttt tatctgggag
     1921 cccaaggagc aagtcctcag gttgctaaaa atattgagac gttgaaggcc ttgcagttaa
     1981 ccaaggagga gtggcgccag gcttatcagt ttgttttgat caaggctggg aaaacagagc
     2041 cattacaggc caaccaccaa tttaccccag acgcgatcgg ctttatcatg ctttatattt
     2101 tggagacctt gagctcacaa gagtcacttg atgtgcttga gattggcagt gggacaggca
     2161 atctggctca caccatttta aaccattcac accaagcgat tcattattta ggcattgagc
     2221 ttgatgattt attaattgat ctatcagcta gtattgctga aatcatgggg tcgtcagccc
     2281 agtttattca agaggatgct gtcagacctc agttgttaaa agaaagtgat atgatcatta
     2341 gtgatttgcc agttggcttt tatcctaacg atgatattgc cagcaggtat caggtggcta
     2401 gctcagatga gcatacctat gcccatcatt tactgatgga gcaggcctta aagtacctga
     2461 aaaaagatgg ctttgctatt ttcttagcac cggtaaatct tttgagcagc ccacaaagtc
     2521 acctcttaaa acaatggctg aagggctatg ctcaggttgc ggccttgatt actttgcctg
     2581 aggctgtgtt tggaaatcca gctaatgcaa aatcgattat tgttctttgt aagcaatcga
     2641 atcgctttgc agaaaccttt gtttacccca ttagggattt gaaatctgtt gataatgttc
     2701 gtgattttat ggaaaacttc aaaaattgga aacgggataa tgttatttaa cggaattttt
     2761 tgatataata gaaaagcatt gcagaaaacg atttcaagag aggtaaaaca tgtcaaagac
     2821 aattgcaatt aatgcaggaa gctccagctt aaaatggcag ctatatcaaa tgccagagga
     2881 aaaggtatta gcacagggaa ttatcgaacg tatcggtctg acagactcaa tctctactgt
     2941 taaattcgat ggcaaaaaag aagagcatat tcttgatatt ccagatcata cagaggctgt
     3001 taagcgcttg ttgaatgatt tgattcattt tggcattatt ggtacgtatg acgagatcac
     3061 aggtgttggg caccgtattg ttgcaggtgg tgaatacttt aaggaatctg tggttgttga
     3121 tgataaggtt gttgagcagg ttgaggagtt agcagccttg gcacccttgc acaatccggg
     3181 ggcagcagca ggtattcgtg cctttcgtaa gattttgccg gacattacga gtgtttgtgt
     3241 gtttgatacg tcgtttcata ccacaatgca aaagcatacc tacctttatc caattcctca
     3301 aaaatattat acagattata aggttcgcaa gtacggggcg catgggacta gccataaata
     3361 tgttgctgag gaagcagcaa aaatgctggg tcgccctcta gacgaattaa agctcattac
     3421 agcccatgtt ggtaatggtg tgtctatcac agccaattat catggtcagt cagtggatac
     3481 ttctatgggc tttacaccgc ttgctggtcc gatgatgggg acacgctctg gtgatattga
     3541 tcctgctatt attccttatt tgattgctca ggatcctgag ctaaaggacg cagcagatgt
     3601 ggtcaatatg cttaacaagc aatctggatt aggtggtgtg tctggtattt ccagtgatat
     3661 gcgtgatatt gaggctggct tgcaggctaa caatccagat gccgtcttag cttacaatat
     3721 ctttattgat cgtatcaaga aatttatcgg acaatacttt gcggtattaa atggtgcaga
     3781 tgccttggtc tttaccgcag gtatgggtga gaatgcgccc ttgatgcgcc aagatgtcgt
     3841 taatggcttg tcatggtttg gtatggaaat tgatccagag aaaaatgtgt ttggttatcg
     3901 tggtgatatt tcaacagcag cttcaaaggt gaaggtgctt gtcatctcaa ctgatgaaga
     3961 gctgtgtatt gcgcgtgacg ttgaacgctt gaaacagact atatcataat ctgataatat
     4021 aatcttagct cagctgatca cttttaaaag ggttgagttt ggggcaaaag actaacgatc
     4081 aatctaaaaa aacacgaaca aaagtatatt tctagtcaat aggtttatac ttttgttcgt
     4141 tttgctatgt taatcactgt ggatcgaggt ttcataaaaa gagtctgaga caaaaagtca
     4201 tctcagtcga gaaaaatagg caattatttt tcgtgtaagt tcctatttta gtattgaatc
     4261 atttttttat tgtacttgat aagagtatta gctataagaa ctaatctcat atcagtttta
     4321 atccgctgtt tatctattaa atattctttg atattaacga tatgatctta gataataagt
     4381 ttaaaagcaa aatgcttact aaaaataaag aggtaatagc attaaagcaa tattacctca
     4441 aagattctac agatatgttt tggttattta tttaaaaatc aattttatga atatataaac
     4501 taatattgtg atagcaatga ccttaccagc atttgccttt accttttgat ctttcaaaaa
     4561 gacttgtgat aatataagac aaattaatcc agatataata gttatcgcca tatgattaac
     4621 tacaagccag tcgcaattcc tgaagcaata caaacaaatg ctgctgcacc acctgttatt
     4681 ggacctccag ctgctgcaag taatacacca cctatacaac cacctatagc agagccaatg
     4741 ttcccacctc cgccgtatac attagttaac gcttgatctt gtaattctaa aaaattattc
     4801 atatactttt acctttatat tagaatttta tattatttcc tatcatgcca cctatacaag
     4861 ttattccacc tgcaatcgcc ccaatatgag ctccaacaaa tgctccagca ggccctccta
     4921 cacctaatgt aaccagacct gaaccaactc ctccagttat agcaccacca ctaataccac
     4981 caattaaatg atttctacag tcagtagcat tatagcctcc tataatatcg gctaattctt
     5041 cacttgttaa ttttttactt cgtttaaaca tatttattta aaaagcctcc cattctatat
     5101 ttgtcaaact gctgcaatct aacaaactaa atgtagcaca tcctatcatg atttgtcaat
     5161 ttagaagcgg ttacattaga gtaaatagag tttttctttt tacctaaatt aattttaatt
     5221 taagtaaaaa gaatattatg ttactatttg acctatggta ttattttcgt tttataccta
     5281 gagttatcac atgctgatga ggtcaatcag tttttttgat tatttggaac atttttgacg
     5341 gttattactc caaagagttt aagctttggc ttggacctgg aaaatcatga ggtaactgct
     5401 tagcggtagg ggtggatttg tttgcccttt attgatagtt agaggagcta gtagcctgtt
     5461 tagattggct ggtctgcaat cttgagccca agggctgttg atggtgctgg ataagaaatt
     5521 gtgcccaatg ggggctagtt tattgtaatc gttttcgata gaatgacttt agaaaggaaa
     5581 tcaaatggtt gatagcaaag cagttgtcat tttgatgact ttgatgactt atcaagactt
     5641 atcactttac gagctgagtg ttaagacaaa attcaccatt agagagatta aggaccgtat
     5701 tgatgagctg aatgattttt tggctcagca tgagctctca gagctgcaga caacaagatc
     5761 tggttatcgg atcagtcagc agcttaaggc tgagtcagat catttgttta cgttgattaa
     5821 tgctgagcag gtctatcttt ctcaggcaga gcggatcaat cttatctatc tgtatacctt
     5881 ttgccgtagg gattttgttt caaatagtca ttatcaggac tttttaaagg tcagcaagaa
     5941 cacagcattg acagatatta aggccttgcg gcagaagctg gcagatgttg acttggaatt
     6001 aaggtatacc agagcaagtg gctatactct agttggtgat gagcttgata agcaccgatt
     6061 agctttggct atgattgcta ctctgcttaa atctcctatt ggcttgtggg ccttggatta
     6121 tattttggct tcttggcact atcaggtgtc gtttgaagcg cttgaaaaac gtgtgagcca
     6181 tttttatcag acctttcaga tgtctccaat ccttgatcgt ctgcaggcct gtttgtacgc
     6241 tttcatcttt attttatgtc gttaccaaag acgggtggat agagtcaagc aaagaccggt
     6301 agtagtttct gagcagctgg atcagctaac agcccttttg gtgtcagaaa taatgcagca
     6361 attgtctctt aggtatcagc tatttgaagc tgatgaggcc tattttcaat tgctgttagc
     6421 gggctgcttt gagggtgagg ggactgtcag tgatgatttc tttgaatcac taaccgctgc
     6481 gattgttgat caaatgcagg gggttgcttt actaagcttc agccaatcag atcagctcaa
     6541 ggaggatttg aagaggcatt tgatcccagc ctattaccgt ttgcgctatg gtttgccaag
     6601 tgataatgat tataccttgc gggttaagga tagttattct gagctctttg acttggtaaa
     6661 gcagtctctg gagcctttag ccaaggagct ggatagtccc ataccagata gtgagattgc
     6721 ttattttgtt cttcattttg gaggctattt aaagcagcag ggaaaagatt ttcatcgtca
     6781 agcctatcgg gctgtgattg tctgtcctaa tggtgttagt tcttctttaa tgatcaagga
     6841 gcatttaaag cttttatttc ctgatattgc ttttcgggga ctttcaaggc ttgatcagct
     6901 tgggcaatta gatgagagcg gctatgattt ggttttttca acgatacgat tagagactga
     6961 taagcccttt tatttggtac ctatgataat gactgatgag caggcttttc agctggttag
     7021 cttggttaat cgtgattttc cagatattgg ctatcggcta gaggttgaag agctgctcca
     7081 tcttatcagc tcatatgcgg tcattcatca aaaagaaaag ctgcgctttg ctttgcagca
     7141 atatttaaga caagatgtga aaagaaagga tattcgacca gtgttacaag acttaattac
     7201 caagaaaacc tatcaatcaa cctcagagca attggggtgg agagaggcta tttatttggc
     7261 ggctcagccc ttgttagaga gtgggcagat tcaagcgagc taccaggagg ctatgattgc
     7321 taaggttgag gagtttggtc cttttattaa tctaggtaag gggattgcta tcccacatgc
     7381 gaggccagag gatggtgtga atcaggtagg tatgtcgatg cttgttttag agcacccgat
     7441 ttatttgtta gatgatccta agcaggagat tcgtttgtta atttgtattg ctgctattga
     7501 taatgaaaca catctaaagg ccctgtctcg gctgacgacc attttaagag acaatgagca
     7561 ggtaaaggct ttacttgcgt ctaaatcatt tgaggatatt aaaactatta ttgcagagga
     7621 ggcataaaat ggcattgaga attggtacag cctgtggttc aggcttaggg tctagcttta
     7681 tggttcagat gaatatcgaa tccgtattaa aggacttggg agtaaccggt gttgaggtgg
     7741 agcattatga tcttggcggc gcggacccca cagcggcaga tgtgtggatt gtagggcgtg
     7801 atttggcaga ctcggcaggg catctgggag atgtgagaat tttaaatagt atcattgata
     7861 tggacgaatt gactagtctg gtaaaggcta tttgccagga aaaggggctt gtctagaagg
     7921 aggataagat gacattttta cttgatattg ttagcacacc agctattttg gttgccttga
     7981 ttgctattgt tggtctcttg cttcaaaaaa agcctgctcc tgacattgtt aagggaggca
     8041 ttaagacctt tgttgggttt ttagtggttt caggtggtgc aggtattgtg caaggctcac
     8101 tcaatccttt tggaacgatg tttgagcatg cctttcatct gtctggggtt gtgccaaata
     8161 atgaggctat tgttgcagtt gctttgacga cctatgggtc agcgacagct ctcattatgt
     8221 ttacaggaat gatctttaat attttgattg ctcgctttac ccgctttaag tatatcttct
     8281 tgacggggca tcatacgctt tacatggcct gtatgattgc tgtgattatg tctgttgcag
     8341 gctttacatc agtgtccttg attgtgtttg gtgggctggc cttagggatt atcatgagta
     8401 tttcaccagc tcttgtgcaa agatacatga ttcagctgac gggacatgac aaggtcgctt
     8461 tggggcattt tagctctctt ggttattggt taagcggttt tgtgggaggt cttgttggag
     8521 acaagaccaa gtcaacagag gacatcaatt ttccaaagag ccttgccttt ttgcgcgata
     8581 gtacggtaag cattaccctg tcaatggcaa tcatttattt gattgtagct atttttgcag
     8641 gtcctgcttg gattagcaag gaattatcct ctggcacaca tggcttggtt tttgctttac
     8701 aattggcagg acaatttgct gcaggtgtct ttgtgatatt agctggtgtt cggctgatcc
     8761 taggtgaaat tgtgccagcc ttcaagggca tttctgaaaa attagtgcca cattctaagc
     8821 cagccttgga ttgtcctatt gtttaccctt atgccccaaa tgcagtgcta attggctttg
     8881 tatctagctt tattggtggc ttggtgagta tggctgtgat gatagcaagt ggaaccacgg
     8941 tgattttgcc tggtgttgtg cctcatttct tctgtggtgc aacagctggt gttattggta
     9001 atgcctctgg aggtgtgcgc ggtgcaactg tgggagcctt cttacagggt gttcttatta
     9061 gttatcttcc tattttcttg atgcctgttt taggtggtct aggctttgag ggctcaacat
     9121 tctcagatgc cgattttggc ttatcaggta ttctattagg gacacttcgt cagatgggcg
     9181 gtgtgacagc tattgtgatt ggcatttttg tgatattagc tggacttgtt gggctttctg
     9241 ttgttggaaa atcagcagct aaggaggaat aa
//
