LOCUS       NZ_CP012871.1          10624 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  NZ_CP012871.1 [Enterobacter] lignolyticus strain G5 chromosome,
            complete genome.
ACCESSION   NZ_CP012871
VERSION     NZ_CP012871.1
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 6.1.1
            Run date     :: 2024-03-14 16:01:50
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 4673451
            Orig. end    :: 4684075
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..10624
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[4678451:4679075](+)"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193)"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      5001..5624
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193)"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
     cand_cluster    1..10624
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193)"
                     /kind="single"
                     /product="RiPP-like"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..10624
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="RiPP-like"
                     /region_number="6"
                     /rules="(strepbact or Antimicrobial14 or Bacteriocin_IId or
                     BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or
                     Lactococcin or Antimicrobial17 or Lactococcin_972 or
                     Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or
                     TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or
                     TIGR03975 or DUF692 or TIGR01193)"
                     /tool="antismash"
     CDS             complement(2476..2991)
                     /locus_tag="ctg1_4264"
                     /transl_table=11
                     /translation="VIPLLAVAAWSGTGKTTLLKALIPLLCAQGIRPGLIKHTHHNMDV
                     DIPGKDSYELRKAGAAQTIVASAQRWALMTETPEENELDLHYLVSRLDPSTLDLVLVEG
                     FKHEAVPKILLFRSGTGHRIEELTLDAHVIAVASDIVLPLSVPVLDLNNPAAIALFIKT
                     WIAAANTA"
     aSDomain        complement(2500..2979)
                     /aSDomain="TIGR00176"
                     /aSTool="tigrfam"
                     /description="mobB: molybdopterin-guanine dinucleotide
                     biosynthesis protein B"
                     /detection="hmmscan"
                     /domain_id="TIGRFam_ctg1_4264_0049"
                     /evalue="1.20E-48"
                     /identifier="TIGR00176"
                     /label="ctg1_4264"
                     /locus_tag="ctg1_4264"
                     /protein_end="164"
                     /protein_start="4"
                     /score="163.1"
                     /tool="antismash"
                     /translation="LAVAAWSGTGKTTLLKALIPLLCAQGIRPGLIKHTHHNMDVDIPG
                     KDSYELRKAGAAQTIVASAQRWALMTETPEENELDLHYLVSRLDPSTLDLVLVEGFKHE
                     AVPKILLFRSGTGHRIEELTLDAHVIAVASDIVLPLSVPVLDLNNPAAIALFIKTW"
     PFAM_domain     complement(2575..2979)
                     /aSDomain="MobB"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF03205.16"
                     /description="Molybdopterin guanine dinucleotide synthesis
                     protein B"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_4264_0170"
                     /evalue="5.40E-47"
                     /label="ctg1_4264"
                     /locus_tag="ctg1_4264"
                     /protein_end="139"
                     /protein_start="4"
                     /score="159.1"
                     /tool="antismash"
                     /translation="LAVAAWSGTGKTTLLKALIPLLCAQGIRPGLIKHTHHNMDVDIPG
                     KDSYELRKAGAAQTIVASAQRWALMTETPEENELDLHYLVSRLDPSTLDLVLVEGFKHE
                     AVPKILLFRSGTGHRIEELTLDAHVIAVASD"
     CDS             complement(2988..3572)
                     /locus_tag="ctg1_4265"
                     /transl_table=11
                     /translation="VNQDRAITGVILAGGRATRMGGKDKGLQPLNGKPLWRHVADALQK
                     QVGQLAISANRHLAIYRESGFAVYPDGVANYPGPLAGMLSVMQQADGEWFLFCPCDTPF
                     IPATLAERFWQQKGAAPVVWAHDGERDHPAIALVNRCIIPQLLEYLTQGERRVMVFMRK
                     AGGHPVDFSDSHDAFINVNTLDDLQHMQEKS"
     aSDomain        complement(3009..3554)
                     /aSDomain="TIGR02665"
                     /aSTool="tigrfam"
                     /description="molyb_mobA: molybdenum cofactor
                     guanylyltransferase"
                     /detection="hmmscan"
                     /domain_id="TIGRFam_ctg1_4265_0050"
                     /evalue="3.00E-67"
                     /identifier="TIGR02665"
                     /label="ctg1_4265"
                     /locus_tag="ctg1_4265"
                     /protein_end="188"
                     /protein_start="6"
                     /score="224.2"
                     /tool="antismash"
                     /translation="ITGVILAGGRATRMGGKDKGLQPLNGKPLWRHVADALQKQVGQLA
                     ISANRHLAIYRESGFAVYPDGVANYPGPLAGMLSVMQQADGEWFLFCPCDTPFIPATLA
                     ERFWQQKGAAPVVWAHDGERDHPAIALVNRCIIPQLLEYLTQGERRVMVFMRKAGGHPV
                     DFSDSHDAFINVNTLDDLQ"
     PFAM_domain     complement(3096..3548)
                     /aSDomain="NTP_transf_3"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF12804.9"
                     /description="MobA-like NTP transferase domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_4265_0171"
                     /evalue="7.80E-34"
                     /label="ctg1_4265"
                     /locus_tag="ctg1_4265"
                     /protein_end="159"
                     /protein_start="8"
                     /score="117.4"
                     /tool="antismash"
                     /translation="GVILAGGRATRMGGKDKGLQPLNGKPLWRHVADALQKQVGQLAIS
                     ANRHLAIYRESGFAVYPDGVANYPGPLAGMLSVMQQADGEWFLFCPCDTPFIPATLAER
                     FWQQKGAAPVVWAHDGERDHPAIALVNRCIIPQLLEYLTQGERRVMV"
     PFAM_domain     3642..3899
                     /aSDomain="DUF1040"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF06288.15"
                     /description="Protein of unknown function (DUF1040)"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_4266_0172"
                     /evalue="1.90E-45"
                     /label="ctg1_4266"
                     /locus_tag="ctg1_4266"
                     /protein_end="86"
                     /protein_start="0"
                     /score="153.2"
                     /tool="antismash"
                     /translation="MKCKRLNEVIELLQPAWQKEPDLNLMQFLQKLAKESGFDGELTDL
                     SDDILIYHLKMRDSAKDAAIPGIQKDYEEDFKTALLRARGV"
     CDS             3642..3911
                     /locus_tag="ctg1_4266"
                     /transl_table=11
                     /translation="MKCKRLNEVIELLQPAWQKEPDLNLMQFLQKLAKESGFDGELTDL
                     SDDILIYHLKMRDSAKDAAIPGIQKDYEEDFKTALLRARGVIKE"
     CDS             3988..4974
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) APH"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg1_4267"
                     /sec_met_domain="APH (E-value: 4.5e-44, bitscore: 149.1,
                     seeds: 156, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNDKAFTFQTLHPDTIMDALFEQGIRVDSGLTPLNSYENRVWQFQ
                     DEDRRRFVVKFYRPQRWSAEQINEEHQFALELQADGVPVAAPVVFNDQTLLSHQGFFFA
                     VFPSVGGRQFEPDNLDQMEWVGRYLGRLHQTGRKKNFVARPGIGVKEYLLEPRQVFENT
                     LLIPSSLKGELLAAVDKLIDAVMGLWHNRFTPLRLHGDCHAGNILWRDGPLFVDLDDAR
                     NGPAVQDLWMLLHGDNAERRMQLDIILEAYEEFSTFDTAELAFIEPLRAMRMVYYLAWL
                     IRRWDDPAFPVNFPWLAEEDSWRNQIKMFLEQARVLQEPPLQLTPMY"
     PFAM_domain     4081..4773
                     /aSDomain="APH"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF01636.25"
                     /description="Phosphotransferase enzyme family"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_4267_0173"
                     /evalue="5.00E-44"
                     /label="ctg1_4267"
                     /locus_tag="ctg1_4267"
                     /protein_end="262"
                     /protein_start="31"
                     /score="151.0"
                     /tool="antismash"
                     /translation="TPLNSYENRVWQFQDEDRRRFVVKFYRPQRWSAEQINEEHQFALE
                     LQADGVPVAAPVVFNDQTLLSHQGFFFAVFPSVGGRQFEPDNLDQMEWVGRYLGRLHQT
                     GRKKNFVARPGIGVKEYLLEPRQVFENTLLIPSSLKGELLAAVDKLIDAVMGLWHNRFT
                     PLRLHGDCHAGNILWRDGPLFVDLDDARNGPAVQDLWMLLHGDNAERRMQLDIILEAYE
                     EFSTFDTAE"
     CDS             5001..5624
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: TIGR03651"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg1_4268"
                     /sec_met_domain="TIGR03651 (E-value: 5.5e-05, bitscore:
                     21.4, seeds: 9, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKKIWLALAGMILAFSASAAQITDGKEYTTLDKPVAGEPQVLEFF
                     SFYCPHCYQFEEVLHVSDTVKKKLPEGTKMTKYHVEFLGPLGKDLTQAWAVAMALGVED
                     QITAPMFEAVQKTQTVQTVADIRQVFVNAGVKGEDYDAAWNSFVVKSLVAQQEKAAADL
                     QLQGVPAMFVNGKYQLNPQGMDTSNMDAFVQQYADTVKQLVEKK"
     PFAM_domain     5118..5588
                     /aSDomain="DSBA"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF01323.22"
                     /description="DSBA-like thioredoxin domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_4268_0174"
                     /evalue="1.80E-28"
                     /label="ctg1_4268"
                     /locus_tag="ctg1_4268"
                     /protein_end="196"
                     /protein_start="39"
                     /score="99.7"
                     /tool="antismash"
                     /translation="QVLEFFSFYCPHCYQFEEVLHVSDTVKKKLPEGTKMTKYHVEFLG
                     PLGKDLTQAWAVAMALGVEDQITAPMFEAVQKTQTVQTVADIRQVFVNAGVKGEDYDAA
                     WNSFVVKSLVAQQEKAAADLQLQGVPAMFVNGKYQLNPQGMDTSNMDAFVQQY"
     CDS             complement(5672..6586)
                     /locus_tag="ctg1_4269"
                     /transl_table=11
                     /translation="MSRLLAAITLLLSIALTIVVTVICSVPIIIAGIIKLLLPVPAVWR
                     SISVFCNLMMYCWCAGLAVLLRLNPRLQWDVEGLEGLNKKNWYLLICNHHSWADIVVLC
                     VLFRKHIPMNKYFLKQQLAWVPFIGLACWALDMPFMRRYSRGYLIRHPERRGKDVETTR
                     RSCEKFRAHPTTIVNFVEGSRFTEEKRRQTRSPFKNLLPPKAAGIAMALNVLGTQFDKL
                     LDVTLCYPENDKTPFYDMLSGKLTRIVVRINLVSVNDELHGDYVNDKNFKRGFQQWLNV
                     LWNDKDVLIEDIKAGRAAVKKRA"
     PFAM_domain     complement(5900..6364)
                     /aSDomain="Acyltransferase"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF01553.23"
                     /description="Acyltransferase"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_4269_0175"
                     /evalue="8.40E-14"
                     /label="ctg1_4269"
                     /locus_tag="ctg1_4269"
                     /protein_end="229"
                     /protein_start="74"
                     /score="51.4"
                     /tool="antismash"
                     /translation="DVEGLEGLNKKNWYLLICNHHSWADIVVLCVLFRKHIPMNKYFLK
                     QQLAWVPFIGLACWALDMPFMRRYSRGYLIRHPERRGKDVETTRRSCEKFRAHPTTIVN
                     FVEGSRFTEEKRRQTRSPFKNLLPPKAAGIAMALNVLGTQFDKLLDVTLCY"
     CDS             6983..9769
                     /locus_tag="ctg1_4270"
                     /transl_table=11
                     /translation="MVQIQENPLILVDGSSYLYRAYHAFPPLTNSAGEPTGAMYGVLNM
                     LRSLILQYQPTHAAVVFDAKGKTFRDELFEHYKSHRPPMPDDLRAQIEPLHAMVRAMGL
                     PLLAVSGVEADDVIGTLAREAEKVGRPVLISTGDKDMAQLVTPGITLINTMTNTVLGPD
                     EVVTKYGVPPELIIDFLALMGDSSDNIPGVPGVGEKTAQALLQGLGGLDVLYAQPEKIA
                     ELSFRGAKTMAAKLEQNKEVAYLSYQLATIKTDVALEQGCEQLEVQPPAADTLVELFKK
                     YEFKRWTTDVESGKWLQAKGGKPAAKPVAAPVAEEDAEEVVSALSAEHYVTVLDEETLK
                     SWIEKLKKAPLFAFDTETDSLDNHSANMVGLSFACEPGVAAYVPVAHDYIGAPEQISRE
                     RALELLKPLLEDEKALKVGQNLKYDRGILANYGIELRGIAWDTMLESYTLDSVAGRHDM
                     DSLSERWLKHKTITFEEIAGKGKNQLTFNQIDLEQAGRYAAEDADVTLQLHLKMWPKLQ
                     KREGPLNVFRNIEMPLVPVLSRIERNGVKIDPLVLQKHSEEITLRLAELEQKAHDIAGE
                     PFNLSSTKQLQTILFEKQGIKPLKKTPGGAPSTSEEVLEELALDYPLPKVILEYRGLAK
                     LKSTYTDKLPLMINPKTGRVHTSYHQAVTATGRLSSTDPNLQNIPVRNEEGRRIRQAFI
                     APEDYLIVSADYSQIELRIMAHLSRDKGLLKAFAEGKDIHRATAAEVFGLPLESVSAEQ
                     RRSAKAINFGLIYGMSAFGLSRQLNIPRKESQKYMDLYFERYPGVLEYMERTRAQAKEQ
                     GYVETLEGRRLYLPDIKSSNAARRAAAERAAINAPMQGTAADIIKRAMIAVDAWLQEEQ
                     PRVRMIMQVHDELVFEVHKDALDAVSKKIHELMESSMALDVPLLVEVGSGDNWDQAH"
     PFAM_domain     7007..7492
                     /aSDomain="5_3_exonuc_N"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF02739.18"
                     /description="5'-3' exonuclease, N-terminal resolvase-like
                     domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_4270_0176"
                     /evalue="3.20E-54"
                     /label="ctg1_4270"
                     /locus_tag="ctg1_4270"
                     /protein_end="170"
                     /protein_start="8"
                     /score="183.2"
                     /tool="antismash"
                     /translation="LILVDGSSYLYRAYHAFPPLTNSAGEPTGAMYGVLNMLRSLILQY
                     QPTHAAVVFDAKGKTFRDELFEHYKSHRPPMPDDLRAQIEPLHAMVRAMGLPLLAVSGV
                     EADDVIGTLAREAEKVGRPVLISTGDKDMAQLVTPGITLINTMTNTVLGPDEVVTKYG"
     aSDomain        7007..9766
                     /aSDomain="TIGR00593"
                     /aSTool="tigrfam"
                     /description="pola: DNA polymerase I"
                     /detection="hmmscan"
                     /domain_id="TIGRFam_ctg1_4270_0051"
                     /evalue="8.70E-286"
                     /identifier="TIGR00593"
                     /label="ctg1_4270"
                     /locus_tag="ctg1_4270"
                     /protein_end="928"
                     /protein_start="8"
                     /score="948.8"
                     /tool="antismash"
                     /translation="LILVDGSSYLYRAYHAFPPLTNSAGEPTGAMYGVLNMLRSLILQY
                     QPTHAAVVFDAKGKTFRDELFEHYKSHRPPMPDDLRAQIEPLHAMVRAMGLPLLAVSGV
                     EADDVIGTLAREAEKVGRPVLISTGDKDMAQLVTPGITLINTMTNTVLGPDEVVTKYGV
                     PPELIIDFLALMGDSSDNIPGVPGVGEKTAQALLQGLGGLDVLYAQPEKIAELSFRGAK
                     TMAAKLEQNKEVAYLSYQLATIKTDVALEQGCEQLEVQPPAADTLVELFKKYEFKRWTT
                     DVESGKWLQAKGGKPAAKPVAAPVAEEDAEEVVSALSAEHYVTVLDEETLKSWIEKLKK
                     APLFAFDTETDSLDNHSANMVGLSFACEPGVAAYVPVAHDYIGAPEQISRERALELLKP
                     LLEDEKALKVGQNLKYDRGILANYGIELRGIAWDTMLESYTLDSVAGRHDMDSLSERWL
                     KHKTITFEEIAGKGKNQLTFNQIDLEQAGRYAAEDADVTLQLHLKMWPKLQKREGPLNV
                     FRNIEMPLVPVLSRIERNGVKIDPLVLQKHSEEITLRLAELEQKAHDIAGEPFNLSSTK
                     QLQTILFEKQGIKPLKKTPGGAPSTSEEVLEELALDYPLPKVILEYRGLAKLKSTYTDK
                     LPLMINPKTGRVHTSYHQAVTATGRLSSTDPNLQNIPVRNEEGRRIRQAFIAPEDYLIV
                     SADYSQIELRIMAHLSRDKGLLKAFAEGKDIHRATAAEVFGLPLESVSAEQRRSAKAIN
                     FGLIYGMSAFGLSRQLNIPRKESQKYMDLYFERYPGVLEYMERTRAQAKEQGYVETLEG
                     RRLYLPDIKSSNAARRAAAERAAINAPMQGTAADIIKRAMIAVDAWLQEEQPRVRMIMQ
                     VHDELVFEVHKDALDAVSKKIHELMESSMALDVPLLVEVGSGDNWDQAH"
     PFAM_domain     7493..7795
                     /aSDomain="5_3_exonuc"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF01367.22"
                     /description="5'-3' exonuclease, C-terminal SAM fold"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_4270_0177"
                     /evalue="2.00E-29"
                     /label="ctg1_4270"
                     /locus_tag="ctg1_4270"
                     /protein_end="271"
                     /protein_start="170"
                     /score="102.2"
                     /tool="antismash"
                     /translation="VPPELIIDFLALMGDSSDNIPGVPGVGEKTAQALLQGLGGLDVLY
                     AQPEKIAELSFRGAKTMAAKLEQNKEVAYLSYQLATIKTDVALEQGCEQLEVQPPA"
     PFAM_domain     7970..8533
                     /aSDomain="DNA_pol_A_exo1"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF01612.22"
                     /description="3'-5' exonuclease"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_4270_0178"
                     /evalue="2.00E-41"
                     /label="ctg1_4270"
                     /locus_tag="ctg1_4270"
                     /protein_end="517"
                     /protein_start="329"
                     /score="141.7"
                     /tool="antismash"
                     /translation="YVTVLDEETLKSWIEKLKKAPLFAFDTETDSLDNHSANMVGLSFA
                     CEPGVAAYVPVAHDYIGAPEQISRERALELLKPLLEDEKALKVGQNLKYDRGILANYGI
                     ELRGIAWDTMLESYTLDSVAGRHDMDSLSERWLKHKTITFEEIAGKGKNQLTFNQIDLE
                     QAGRYAAEDADVTLQLHLKMWPKLQ"
     PFAM_domain     8636..9757
                     /aSDomain="DNA_pol_A"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00476.22"
                     /description="DNA polymerase family A"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_4270_0179"
                     /evalue="4.80E-159"
                     /label="ctg1_4270"
                     /locus_tag="ctg1_4270"
                     /protein_end="925"
                     /protein_start="551"
                     /score="529.5"
                     /tool="antismash"
                     /translation="LQKHSEEITLRLAELEQKAHDIAGEPFNLSSTKQLQTILFEKQGI
                     KPLKKTPGGAPSTSEEVLEELALDYPLPKVILEYRGLAKLKSTYTDKLPLMINPKTGRV
                     HTSYHQAVTATGRLSSTDPNLQNIPVRNEEGRRIRQAFIAPEDYLIVSADYSQIELRIM
                     AHLSRDKGLLKAFAEGKDIHRATAAEVFGLPLESVSAEQRRSAKAINFGLIYGMSAFGL
                     SRQLNIPRKESQKYMDLYFERYPGVLEYMERTRAQAKEQGYVETLEGRRLYLPDIKSSN
                     AARRAAAERAAINAPMQGTAADIIKRAMIAVDAWLQEEQPRVRMIMQVHDELVFEVHKD
                     ALDAVSKKIHELMESSMALDVPLLVEVGSGDNWD"
ORIGIN
        1 tctagccatg ggcaggttga aggttgggta acactaactg gaggaccgaa ccgactaatg
       61 ttgaaaaatt agcggatgac ttgtggctgg gggtgaaagg ccaatcaaac cgggagatag
      121 ctggttctcc ccgaaagcta tttaggtagc gcctcgtgaa ctcatcttcg ggggtagagc
      181 actgtttcgg ctagggggtc atcccgactt accaacccga tgcaaactgc gaataccgaa
      241 gaatgttatc acgggagaca cacggcgggt gctaacgtcc gtcgtgaaga gggaaacaac
      301 ccagaccgcc agctaaggtc ccaaagtcat ggttaagtgg gaaacgatgt gggaaggcac
      361 agacagccag gatgttggct tagaagcagc catcatttaa agaaagcgta atagctcact
      421 ggtcgagtcg gcctgcgcgg aagatgtaac ggggctaaac catgcaccga agctgcggca
      481 gcgacactat gtgttgttgg gtaggggagc gttctgtaag ccgttgaagg tggcctgtga
      541 gggttgctgg aggtatcaga agtgcgaatg ctgacataag taacgataaa gcgggtgaaa
      601 agcccgctcg ccggaagacc aagggttcct gtccaacgtt aatcggggca gggtgagtcg
      661 acccctaagg cgaggccgaa aggcgtagtc gatgggaaac aggttaatat tcctgtactt
      721 ggtgttactg cgaagggggg acggagaagg ctatgtcatc cgggcgacgg tcgtcccggt
      781 ttaagcgtgt aggtgtgtgt tccaggcaaa tccggagcac tttaacactg aggcgtgatg
      841 acgaggcact acggtgctga agtgacagat gccctgcttc caggaaaagc ctctaagcat
      901 caggtaacac gaaatcgtac cccaaaccga cacaggtggt caggtagaga ataccaaggc
      961 gcttgagaga actcgggtga aggaactagg caaaatggtg ccgtaacttc gggagaaggc
     1021 acgctgatat gtaggtgaag cccctgcggg tggagctgaa atcagtcgaa gataccagct
     1081 ggctgcaact gtttattaaa aacacagcac tgtgcaaaca cgaaagtgga cgtatacggt
     1141 gtgacgcctg cccggtgccg gaaggttaat tgatggggtt atccgtaagg agaagctctt
     1201 gatcgaagcc ccggtaaacg gcggccgtaa ctataacggt cctaaggtag cgaaattcct
     1261 tgtcgggtaa gttccgacct gcacgaatgg cgtaatgatg gccaggctgt ctccacccga
     1321 gactcagtga aattgaactc gctgtgaaga tgcagtgtac ccgcggcaag acggaaagac
     1381 cccgtgaacc tttactatag cttgacactg aacattgagc cttgatgtgt aggataggtg
     1441 ggaggctttg aagtgtggac gccagtctgc atggagccaa ccttgaaata ccacccttta
     1501 atgtttgatg ttctaacgtg gacccgtaat ccgggttgcg gacagtgtct ggtgggtagt
     1561 ttgactgggg cggtctcctc ccaaagagta acggaggagc acgaaggttg gctaatcctg
     1621 gtcggacatc aggaggttag tgcaatggca taagccagct tgactgcgag cgtgacggcg
     1681 cgagcaggtg cgaaagcagg tcatagtgat ccggtggttc tgaatggaag ggccatcgct
     1741 caacggataa aaggtactcc ggggataaca ggctgatacc gcccaagagt tcatatcgac
     1801 ggcggtgttt ggcacctcga tgtcggctca tcacatcctg gggctgaagt aggtcccaag
     1861 ggtatggctg ttcgccattt aaagtggtac gcgagctggg tttagaacgt cgtgagacag
     1921 ttcggtccct atctgccgtg ggcgctggag aattgagggg ggctgctcct agtacgagag
     1981 gaccggagtg gacgcatcac tggtgttcgg gttgtcatgc caatggcatt gcccggtagc
     2041 taaatgcgga agagataagt gctgaaagca tctaagcacg aaacttgccc cgagatgagt
     2101 tctccctgac tccttgagag tcctgaagga acgttgaaga cgacgacgtt gataggccgg
     2161 gtgtgtaagc gcagcgatgc gttgagctaa ccggtactaa tgaaccgtga ggcttaacct
     2221 tacaacgccg aagatgtttt ggcggatttg agatgatttt cagcctgata cagataacag
     2281 aatttgcctg gcggcaaaag cgcggtggtc ccacctgacc ccatgccgaa ctcagaagtg
     2341 aaacgccgta gcgccgatgg tagtgtgggg tctccccatg tgagagtagg gaactgccag
     2401 gcatcaatca agtgaagagc ccatcctgac ggatgggctt tttgcgtttt tgtccttttc
     2461 ttgcgaaaaa gagcatcagg ccgtatttgc tgcggcgatc cacgttttaa taaacaacgc
     2521 gatagcggct ggattgttga gatccagtac cggcacgctc aacggtaaaa caatgtcgct
     2581 ggcgacggcg ataacgtgcg catcaagcgt cagttcttcg atgcgatgac ctgtacccga
     2641 tcggaacagc aggatcttgg gcaccgcttc gtgtttaaac ccttctacca gcaccaaatc
     2701 taacgtcgat ggatccagac ggcttaccag gtaatgcaaa tccagttcat tttcttccgg
     2761 cgtttccgtc atcaacgccc agcgctgcgc gctggccaca atagtttgtg cggcgcctgc
     2821 tttacgcagc tcgtagctgt ctttcccggg aatatcgacg tccatattat ggtgggtgtg
     2881 tttaattaac cccgggcgaa taccctgcgc acatagcagc gggatcaggg ctttcagcag
     2941 cgttgttttg cctgtaccgc tccaggccgc tacggctaac agtgggatca cgacttctcc
     3001 tgcatatgct gtaaatcgtc cagcgtattc acattaataa aggcatcatg gctgtcgcta
     3061 aaatcaaccg gatgcccacc ggcctttcgc ataaaaacca ttacccgacg ttcgccctgc
     3121 gtaagatact ccagcagctg cggtatgatg cagcggttaa ccagcgcaat ggccgggtga
     3181 tcgcgctcgc cgtcatgggc ccataccacc ggcgctgcgc ccttttgctg ccaaaagcgt
     3241 tcggccagcg tagcgggaat aaacggggtg tcgcaggggc aaaacaggaa ccattcgcca
     3301 tcggcctgct gcatgacgga gagcattccc gccagcgggc ctggatagtt cgccacgccg
     3361 tccggataga cggcgaaacc gctctcccgg tagatagcaa gatggcgatt ggcgctaatg
     3421 gcgagttgtc ctacctgctt ttgcagagca tcagcgacat ggcgccataa cggtttccca
     3481 ttaagcggct gtaatccttt atctttacct cccatgcgcg tcgcccggcc gccagccagt
     3541 atcaccccgg taattgcccg atcctgattc accaatatcg cctcttttat tgtgggtttg
     3601 accctgttaa cgtgtgccta tcaagcgtaa ggagcatgac aatgaaatgt aaacgtctta
     3661 acgaagtgat tgaactcctc cagccggcct ggcagaaaga gccagatctg aatcttatgc
     3721 aatttttgca gaaactggcg aaggagtcag gttttgacgg tgaactgacc gacctttctg
     3781 acgatatcct gatctaccat cttaagatgc gtgattccgc gaaagatgcg gcgatccctg
     3841 gcattcagaa agactatgaa gaggatttca aaaccgcgct gctgcgcgca cgcggcgtaa
     3901 ttaaagagta aaagcttgta agcggcgcaa ccgaaatcgt cgtgaaatga tatcctgaat
     3961 cattcgtagt aatttccgga taatcggatg aacgacaagg cttttacttt ccagacatta
     4021 cacccggata ccatcatgga tgcgctgttt gagcagggga tccgggtgga ttcggggttg
     4081 accccgctta acagctatga aaaccgcgtc tggcagtttc aggatgaaga caggcgtcgt
     4141 ttcgtggtga agttctaccg cccacagcgc tggtcagctg aacaaatcaa cgaagaacac
     4201 cagttcgctc ttgagctgca ggcggatggc gtacctgttg ccgctcccgt ggttttcaat
     4261 gaccagacgc tgctctctca tcagggcttc tttttcgcgg tgttcccaag cgtcggcggt
     4321 cgtcagtttg agccggataa tctcgatcaa atggagtggg tggggcgcta cctgggccgt
     4381 ctgcatcaga ccgggcgtaa aaaaaacttt gttgcgcgtc cgggtattgg ggtgaaggag
     4441 tatctgcttg aacctcgcca ggtgtttgaa aacacattac ttattccatc atcccttaaa
     4501 ggtgagcttc ttgccgcagt agataaactg atcgacgcgg tgatggggct gtggcacaac
     4561 cgctttaccc ccctgcgtct gcacggtgac tgccatgccg ggaatattct gtggcgtgac
     4621 ggtccgctgt ttgtcgatct ggacgacgcg cgtaacggtc cggcggttca ggatctgtgg
     4681 atgttgctgc atggcgataa tgccgagcgc cgcatgcagc tcgatatcat tcttgaagcc
     4741 tatgaagagt tcagtacctt cgacaccgct gagcttgcct tcatcgaacc gttgcgcgcc
     4801 atgcggatgg tgtattacct ggcgtggtta atccgccgct gggatgaccc tgcgtttccg
     4861 gtgaacttcc cctggcttgc cgaggaagat agctggcgca accaaataaa aatgtttttg
     4921 gaacaagcac gggttcttca ggaacctccg ttacaattaa cgccaatgta ttaactgaca
     4981 tattcaggag agagttgacc atgaagaaaa tttggctggc gctggcagga atgattctgg
     5041 cattcagcgc atcggctgcg cagatcaccg atggtaagga atataccacc cttgataagc
     5101 cggttgccgg tgaaccacag gtgcttgagt tcttctcatt ttattgcccg cactgctacc
     5161 agtttgagga agtgctgcac gtttccgata cggtgaagaa aaagctgccg gaaggcacca
     5221 aaatgaccaa ataccacgtg gagttcctgg gaccgttggg taaagacctg actcaggcct
     5281 gggcagtggc aatggcgctg ggcgtggaag accagatcac ggcgccgatg tttgaagctg
     5341 tgcagaaaac acaaaccgtt cagaccgttg ccgatattcg ccaggtcttt gttaacgccg
     5401 gcgtgaaagg tgaagactac gacgcggcct ggaacagttt cgtagtgaaa tcgctggtcg
     5461 cgcagcagga aaaagcggca gccgatctgc agctgcaggg cgtgccggcc atgtttgtta
     5521 acggtaaata ccagctgaac ccgcagggta tggacaccag caacatggac gctttcgttc
     5581 agcaatatgc tgataccgtg aagcaactgg ttgagaaaaa ataaaaaaac gccggtcact
     5641 gaccggcgtt ttcatttctg gtatctgctt ttcaggctcg ctttttcacc gccgcccgtc
     5701 ccgctttaat gtcttcaatc agcacatctt tatcgttcca caggacgttc agccactgct
     5761 ggaatccgcg cttaaagttc ttatcgttga cgtaatcgcc gtgcagctca tcgttgacgg
     5821 acaccaggtt gatgcgcacc acaatgcgcg tcagtttacc gctcagcatg tcataaaacg
     5881 gagtcttgtc gttttccggg tagcacagcg tgacgtccag cagcttatcg aactgggtac
     5941 ccagcacgtt tagcgccatc gcaatacccg ccgcttttgg cggcagcagg tttttgaacg
     6001 gggaacgcgt ctggcggcgc ttttcttcgg taaagcggga gccttcgaca aagttaacga
     6061 tagtcgtcgg atgcgcgcga aacttctcgc aggagcgacg ggtggtttcg acatcttttc
     6121 cgcgacgttc cgggtggcgg ataaggtagc cgcgggaata gcggcgcata aacggcatat
     6181 ccagcgccca gcatgccagg ccgatgaaag gcacccaggc aagctgttgc ttcagaaagt
     6241 acttattcat tgggatatgt ttacggaaca gtacgcacag caccacgatg tctgcccagc
     6301 tgtgatggtt gcatatcagc aggtaccagt tctttttatt gagtccttcc agcccttcaa
     6361 catcccactg tagccgcggg ttcaggcgca gcagtaccgc aagcccggcg caccagcagt
     6421 acatcatcag attgcagaag acggagattg agcgccagac cgcaggaacg ggcagcagca
     6481 gcttaatgat cccggcgata ataatcggca ccgaacagat cacggtgact acaatggtaa
     6541 gagcgatact cagcagaagc gttatcgcag cgagcaatct cgacataatc aatttattca
     6601 gatagttaat tgtaaattgt gcgtgcttta cgggcgcaag gcgctgattt tatcagaaaa
     6661 cgcgtcaaat gacgggtcat accagaatag aaaaatagac attgtgaata tccacatagc
     6721 acaaaatgtc gacacgaagg taaaagatga tattgatgtt ttataacaca atgaaatata
     6781 agaaaaatga aatctaaaag atctttccgt tattagcatt tactcgccgg aataaatcta
     6841 tacacaaact tatccacagg tgctttttgc gagagatcca gaggatctgt aaatcttttg
     6901 ccgcaataat ggtgaaaaat tcatgtttta cctccgtctg tggcattctt taaccctaat
     6961 ctgataaaca ggcacggaaa ttatggttca gatccaagaa aatcccctca tcctggttga
     7021 tggctcctcc tatctctacc gcgcgtatca cgcgtttcct ccgctgacca acagcgccgg
     7081 ggaaccgacg ggagcaatgt acggcgtgtt gaatatgctg cgcagcctca tcctgcagta
     7141 tcagcctacc catgcggcgg tagtgtttga tgccaagggg aaaaccttcc gtgatgaact
     7201 gtttgaacat tacaaatccc accgtcctcc gatgccggac gatcttcgcg cgcagattga
     7261 accgctgcac gcgatggtca gagcgatggg gctaccgctg ctggccgttt ccggcgtgga
     7321 agcggacgac gttatcggta cgctggcgcg ggaagcggaa aaagtcggcc gcccggtgct
     7381 tatcagcacg ggcgataaag acatggcgca gctggtgacg ccgggtatta ccctgattaa
     7441 caccatgacc aacaccgtgc tcgggccgga tgaggtggta accaaatacg gcgtaccgcc
     7501 ggagcttatc atcgatttcc tcgcactgat gggcgactcg tcggacaaca ttcctggcgt
     7561 gcctggcgtc ggtgagaaaa cggcgcaggc gctgctgcag gggcttggcg gtcttgatgt
     7621 tctgtatgcg cagccggaga aaatcgctga gctgagcttc cgcggcgcga aaacgatggc
     7681 cgcgaagctt gagcaaaaca aagaggttgc ctacctctcc tatcagctcg ctaccatcaa
     7741 aaccgatgtt gctctggagc agggctgcga gcagcttgaa gtgcagccgc cggccgccga
     7801 cacgctggtg gagctgttta aaaagtatga gtttaagcgc tggacgacgg acgttgagag
     7861 cggtaaatgg ctgcaggcga aaggcggcaa acccgcggcg aaacctgtgg ccgcgccggt
     7921 tgcagaagaa gacgcggaag aggtcgtttc cgcgctgtcg gcggagcact acgtcaccgt
     7981 tctcgatgag gagacgctga aaagctggat cgagaagctg aaaaaggcgc cgctgtttgc
     8041 gtttgatacg gaaacggata gcctcgacaa ccactccgcc aacatggtgg ggctgtcgtt
     8101 cgcctgcgag ccgggcgttg cggcctatgt tcctgtcgcg catgactata tcggcgcgcc
     8161 ggagcaaatt tcccgtgagc gggcgctgga gctgcttaag cccctgctgg aagatgaaaa
     8221 ggcgctgaag gtcgggcaaa acctgaagta tgatcgcggt atcctggcga attacggtat
     8281 tgagctgcgc gggattgcct gggacaccat gctggagtcc tatacgctgg atagcgttgc
     8341 cggtcgtcat gacatggaca gcctttccga gcgctggctg aagcataaaa ccatcacctt
     8401 cgaagagatt gccggtaagg gtaagaacca gctgaccttc aaccaaatcg atcttgagca
     8461 ggccgggcgc tatgcggcgg aagatgccga cgtcactctg cagctgcatc tgaagatgtg
     8521 gccgaagctg caaaagcgcg aaggtcctct caacgttttc cgcaatatcg aaatgccgct
     8581 ggtgccggtg ctctcccgta tcgaacgtaa cggcgtgaaa atcgatccgc tggtgctgca
     8641 aaagcactcg gaggagatta ccctgcgcct ggcggagctt gagcaaaaag cgcatgacat
     8701 tgccggcgag ccgtttaacc tctcgtcgac caagcagctg cagaccatcc tctttgagaa
     8761 gcaggggatt aaaccgctga agaaaacccc tggcggcgcg ccgtcgacgt cggaagaggt
     8821 gctggaagag ctggcgctgg actacccgct gccaaaagtc attctggagt atcgcgggct
     8881 ggcgaagctg aaatcgacct acaccgataa gctgccgctg atgattaacc cgaaaaccgg
     8941 ccgtgtacat acgtcttatc accaggcggt taccgcaacg ggacgtctgt cgtcgaccga
     9001 cccgaacctg cagaacattc cggttcgcaa tgaagaaggg cgccgcatcc gccaggcgtt
     9061 tatcgctccg gaagactatc tcatcgtttc tgcggactac tcgcaaattg aactgcgcat
     9121 catggcgcat ctgtcacgcg acaaggggct gctgaaggcg tttgcggaag gcaaagatat
     9181 ccaccgcgcg acggcggcgg aagtgtttgg gctaccgctg gaaagcgttt ccgcggaaca
     9241 gcgccgcagc gcgaaagcga tcaacttcgg tttgatctac ggcatgagcg cgtttggcct
     9301 gtcccgccag ctcaatattc cacgcaaaga gtcgcagaaa tacatggatc tctacttcga
     9361 gcgctatcct ggcgtgctgg agtatatgga gcgcacccgg gcgcaggcaa aagagcaggg
     9421 gtatgtcgaa acgctcgagg gccgtcgcct gtacctgccg gatatcaagt ccagcaacgc
     9481 cgcgcgccgc gccgcggcag agcgtgctgc gattaacgcg ccgatgcagg gtaccgccgc
     9541 agatatcatt aagcgggcga tgatcgccgt tgatgcctgg ctgcaagagg agcaaccgcg
     9601 cgtgcggatg atcatgcagg tacacgatga actggtgttc gaagtgcata aggacgcgct
     9661 ggacgcggtc tcgaaaaaga tccatgagct gatggaaagc agcatggcgc ttgatgtgcc
     9721 gttgctggtg gaagtgggga gcggtgataa ctgggatcaa gcgcactaac cgtacgaaga
     9781 acgtcgcgtg cttttgtaac taagcaacat aacttatcgc tttttgtgat ggctattaga
     9841 ttttgctatg taaagagtga aaaaaaacta caaaaagtac tttgtacgct gagaaaaaaa
     9901 gagtagagtt gttcgcgtag ggtacagagg taagatgttc tatctttcag accttttact
     9961 tcacgtaatc ggatttggct gaatatttta gccgccccag tcagtaatga ctggggcgtt
    10021 ttttattgcg gcaaaaaaaa gcgcggactg tgccgcgcct gagattatgc ttccgcctct
    10081 tcctgcggag ggatctcgct gaaccacgta tccagcttct cgcgcagctt atccacaccc
    10141 tgcttcttca gtgatgaaaa cgcttcaacc tgcacatcgc cgttaaacgc ggcggcggct
    10201 tcacgcacca tattcagctg ggctttacgc gcgccgctgg cgagcttatc ggctttggtc
    10261 agcagaacca gtacctgaat accgctgtcg acggcccatt cgatcatctg ctgatcgagg
    10321 tccttcagcg gatggcgaat gtccattaat accaccaggc ccttcaggca caggcgtttt
    10381 tccaggtatt cgccgagcgc gcgctgccat ttgcgcttca tttcttccgg cacttccgcg
    10441 tagccatagc ccgggaggtc gacaagacgc ttaccgtcgg cgacttcaaa caggttaatg
    10501 agctgcgtac ggcccggcgt ttttgaggtg cgcgccaggc ttttctggtt agtcagcgta
    10561 ttcagcgcgc tggattttcc tgcgttggag cggccggcga acgccacttc aataccgctg
    10621 tcgg
//
