LOCUS       c00263_NZ_CABK..        9144 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  NZ_CABKTV010000263.1 Actinomyces polynesiensis isolate
            MGYG-HGUT-01480, whole genome shotgun sequence.
ACCESSION   c00263_NZ_CABK..
VERSION     c00263_NZ_CABK..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 6.1.1
            Run date     :: 2024-03-14 16:25:23
            Original ID  :: NZ_CABKTV010000263.1
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 9144
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..9144
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="True"
                     /core_location="[3292:4144](-)"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193)"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(3293..4144)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193)"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
     cand_cluster    1..9144
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193)"
                     /kind="single"
                     /product="RiPP-like"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..9144
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="RiPP-like"
                     /region_number="1"
                     /rules="(strepbact or Antimicrobial14 or Bacteriocin_IId or
                     BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or
                     Lactococcin or Antimicrobial17 or Lactococcin_972 or
                     Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or
                     TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or
                     TIGR03975 or DUF692 or TIGR01193)"
                     /tool="antismash"
     CDS             213..1022
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF00881"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg263_1"
                     /sec_met_domain="PF00881 (E-value: 7.7e-18, bitscore: 54.8,
                     seeds: 78, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDAQQQSDRGPGRVAPTTFAENETIRTQLAHRTIRAFTPDPVGEE
                     VVRSLLDVARHAPTSSFYQQTTVLWVRDPVLRHEVYRSSGQPYVDGTRGELLVFVVDLH
                     RNACIREEAGEDLEPLGRTTLFLEGVEDAVIAAQNTVVAAESLGLGTVYLGSIGGDPRR
                     VIRALRLPRHTFPLLGLLVGHPDQEPQFKPRLPADLTTAVDTYPEVEDWGAALAGYDAT
                     VQTYYDLRDANRRVDSFTHQIRTKPGTGRAEQAPVLEVLHEQGLALG"
     PFAM_domain     303..764
                     /aSDomain="Nitroreductase"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00881.26"
                     /description="Nitroreductase family"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg263_1_0001"
                     /evalue="1.90E-14"
                     /label="ctg263_1"
                     /locus_tag="ctg263_1"
                     /protein_end="184"
                     /protein_start="30"
                     /score="54.2"
                     /tool="antismash"
                     /translation="HRTIRAFTPDPVGEEVVRSLLDVARHAPTSSFYQQTTVLWVRDPV
                     LRHEVYRSSGQPYVDGTRGELLVFVVDLHRNACIREEAGEDLEPLGRTTLFLEGVEDAV
                     IAAQNTVVAAESLGLGTVYLGSIGGDPRRVIRALRLPRHTFPLLGLLVGH"
     CDS             1174..2463
                     /locus_tag="ctg263_2"
                     /transl_table=11
                     /translation="MDFDSRYAAVASRDRRFDGRFVTAVRSTGIYCRPSCPARTPKPGN
                     VEFFATSAAAQAAGYRACRRCLPEALPGSPEWDLREDLAARAMRLISQGVVDREGVGGL
                     ASRLGHSTRHLTRVLTDELGAGPLALARSQRAHTARQLLCTTTLPVSEVAFSAGFSSIR
                     QFNDTVREVFGLTPTQLRGRARRAEAVAQVPGAITLRLAHREPLDLRGLFDWYAARAVR
                     GIEDAGGGHLSRTLRTSRGAALVELWGEGREVLARLHLQDPSELPEVLGRVRRALDLDA
                     DPVSVDTALSRDDRLAPHVDEVPGIRIPGEFDLAEALVRAVIGQQVGVEPARRDFARVA
                     RLLADPLPRGSHPRGGRTPRPISCSPPRPSWPSAPSRLYPGRDAGGPRSRRPVRRSRRG
                     ASPSTPPGDVRTRWRPCVRCRGSARGPRTT"
     PFAM_domain     1189..1380
                     /aSDomain="Ada_Zn_binding"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF02805.18"
                     /description="Metal binding domain of Ada"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg263_2_0002"
                     /evalue="1.30E-29"
                     /label="ctg263_2"
                     /locus_tag="ctg263_2"
                     /protein_end="69"
                     /protein_start="5"
                     /score="102.1"
                     /tool="antismash"
                     /translation="RYAAVASRDRRFDGRFVTAVRSTGIYCRPSCPARTPKPGNVEFFA
                     TSAAAQAAGYRACRRCLPE"
     PFAM_domain     1483..1722
                     /aSDomain="HTH_18"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF12833.9"
                     /description="Helix-turn-helix domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg263_2_0003"
                     /evalue="2.40E-19"
                     /label="ctg263_2"
                     /locus_tag="ctg263_2"
                     /protein_end="183"
                     /protein_start="103"
                     /score="69.5"
                     /tool="antismash"
                     /translation="LASRLGHSTRHLTRVLTDELGAGPLALARSQRAHTARQLLCTTTL
                     PVSEVAFSAGFSSIRQFNDTVREVFGLTPTQLRGR"
     PFAM_domain     1765..2112
                     /aSDomain="AlkA_N"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF06029.13"
                     /description="AlkA N-terminal domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg263_2_0004"
                     /evalue="2.70E-26"
                     /label="ctg263_2"
                     /locus_tag="ctg263_2"
                     /protein_end="313"
                     /protein_start="197"
                     /score="92.2"
                     /tool="antismash"
                     /translation="TLRLAHREPLDLRGLFDWYAARAVRGIEDAGGGHLSRTLRTSRGA
                     ALVELWGEGREVLARLHLQDPSELPEVLGRVRRALDLDADPVSVDTALSRDDRLAPHVD
                     EVPGIRIPGEFD"
     CDS             2409..2651
                     /locus_tag="ctg263_3"
                     /transl_table=11
                     /translation="VAALCAVPGIGPWTADHVTMRVTGNPDVLVRGDAAQWRGASRLGL
                     GTTAAELEGEGRAFAPWRSYLGMHLWRASIGRDTP"
     CDS             2648..3196
                     /locus_tag="ctg263_4"
                     /transl_table=11
                     /translation="MTDVGHPAAEAGHLAGLLLVTTLGTPDGPFTVVEETDGTVWASGW
                     SADVGDLLHRAHIAPGTPLAPSRGPSAAVRAVLSLYEGDAAPLAGVPVRRSGTAFQQEV
                     WRGLRDIPVGTTLSYSRLGECIGRPRAVRAVGLACGRNAVAPFVPCHRVVGADGSLTGY
                     AWGLEVKRHLLTLEGALRP"
     aSDomain        2939..3178
                     /aSDomain="TIGR00589"
                     /aSTool="tigrfam"
                     /description="ogt: methylated-DNA--[protein]-cysteine
                     S-methyltransferase"
                     /detection="hmmscan"
                     /domain_id="TIGRFam_ctg263_4_0001"
                     /evalue="8.70E-32"
                     /identifier="TIGR00589"
                     /label="ctg263_4"
                     /locus_tag="ctg263_4"
                     /protein_end="177"
                     /protein_start="97"
                     /score="107.0"
                     /tool="antismash"
                     /translation="TAFQQEVWRGLRDIPVGTTLSYSRLGECIGRPRAVRAVGLACGRN
                     AVAPFVPCHRVVGADGSLTGYAWGLEVKRHLLTLE"
     PFAM_domain     2942..3181
                     /aSDomain="DNA_binding_1"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF01035.22"
                     /description="6-O-methylguanine DNA methyltransferase, DNA
                     binding domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg263_4_0005"
                     /evalue="4.80E-30"
                     /label="ctg263_4"
                     /locus_tag="ctg263_4"
                     /protein_end="178"
                     /protein_start="98"
                     /score="103.5"
                     /tool="antismash"
                     /translation="AFQQEVWRGLRDIPVGTTLSYSRLGECIGRPRAVRAVGLACGRNA
                     VAPFVPCHRVVGADGSLTGYAWGLEVKRHLLTLEG"
     CDS             complement(3293..4144)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: Linocin_M18"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg263_5"
                     /sec_met_domain="Linocin_M18 (E-value: 4e-88, bitscore:
                     284.4, seeds: 61, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSSPNEGPTVAATATTVGTSNLHRWLAPVSDAAWGEIAEEARRTF
                     RRNSAARRVVDVTGPLGLEAAAANTGHLSTIDPPRPGIRSRLREVAPLVELRVPFSVSR
                     AAVDDVLRGAQDSDWQPVKDAATALARAEDAAVFQGYAAAQVRGIAPASSNEPITLPAD
                     ARELPEVVAHALTELRLAGVEGPYALVLDADVHTEASETRDHGYPIRTQLEQLVEQVVW
                     APALSGGCLLSTRGGDYEMVLGQDVSIGYTSHTGEDVELYLQESLTFLTHTDEASVVLV
                     RP"
     PFAM_domain     complement(3341..4087)
                     /aSDomain="Linocin_M18"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF04454.14"
                     /description="Encapsulating protein for peroxidase"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg263_5_0006"
                     /evalue="3.80E-84"
                     /label="ctg263_5"
                     /locus_tag="ctg263_5"
                     /protein_end="268"
                     /protein_start="19"
                     /score="282.1"
                     /tool="antismash"
                     /translation="SNLHRWLAPVSDAAWGEIAEEARRTFRRNSAARRVVDVTGPLGLE
                     AAAANTGHLSTIDPPRPGIRSRLREVAPLVELRVPFSVSRAAVDDVLRGAQDSDWQPVK
                     DAATALARAEDAAVFQGYAAAQVRGIAPASSNEPITLPADARELPEVVAHALTELRLAG
                     VEGPYALVLDADVHTEASETRDHGYPIRTQLEQLVEQVVWAPALSGGCLLSTRGGDYEM
                     VLGQDVSIGYTSHTGEDVELYLQESLT"
     CDS             complement(4141..5235)
                     /locus_tag="ctg263_6"
                     /transl_table=11
                     /translation="VPLDAFQSAQSPQTPAQDPEPQAILTSLTSSAAFLVVTVPGDSSA
                     AGRVLAVAADIGSLVRAVGFREPTASLSCVVGFGADFWDRIRPAGTPRPAQLHAFHPVT
                     GARHNAPSTPGDILFHIRANRPDLVFELTRLLMDAIGADVHVEDHVTGFRYFDSRDLLG
                     FVDGTENPTGRGAVGAALIDTSGEPEFAGGSYVIVQKYVHDMAAWHALSTEEQEHVIGR
                     TKLDDVELDEEVMPTNSHVSLNTIVDEDGTEHDILRDNMAFGDPGRGEFGTYYIAYAAD
                     PSVTEQMLDNMFIGNPPGNYDHILDVSTALTGSLFFVPSLDLLESLPDDVPAQGRPAAG
                     RPDTEPDTSTTESLSIGSLRGTTS"
     aSDomain        complement(4270..5172)
                     /aSDomain="TIGR01413"
                     /aSTool="tigrfam"
                     /description="Dyp_perox_fam: Dyp-type peroxidase family"
                     /detection="hmmscan"
                     /domain_id="TIGRFam_ctg263_6_0002"
                     /evalue="4.90E-83"
                     /identifier="TIGR01413"
                     /label="ctg263_6"
                     /locus_tag="ctg263_6"
                     /protein_end="322"
                     /protein_start="21"
                     /score="277.0"
                     /tool="antismash"
                     /translation="QAILTSLTSSAAFLVVTVPGDSSAAGRVLAVAADIGSLVRAVGFR
                     EPTASLSCVVGFGADFWDRIRPAGTPRPAQLHAFHPVTGARHNAPSTPGDILFHIRANR
                     PDLVFELTRLLMDAIGADVHVEDHVTGFRYFDSRDLLGFVDGTENPTGRGAVGAALIDT
                     SGEPEFAGGSYVIVQKYVHDMAAWHALSTEEQEHVIGRTKLDDVELDEEVMPTNSHVSL
                     NTIVDEDGTEHDILRDNMAFGDPGRGEFGTYYIAYAADPSVTEQMLDNMFIGNPPGNYD
                     HILDVSTALTGSLFFVPSLD"
     PFAM_domain     complement(4270..5172)
                     /aSDomain="Dyp_perox"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF04261.14"
                     /description="Dyp-type peroxidase family"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg263_6_0007"
                     /evalue="2.40E-82"
                     /label="ctg263_6"
                     /locus_tag="ctg263_6"
                     /protein_end="322"
                     /protein_start="21"
                     /score="276.7"
                     /tool="antismash"
                     /translation="QAILTSLTSSAAFLVVTVPGDSSAAGRVLAVAADIGSLVRAVGFR
                     EPTASLSCVVGFGADFWDRIRPAGTPRPAQLHAFHPVTGARHNAPSTPGDILFHIRANR
                     PDLVFELTRLLMDAIGADVHVEDHVTGFRYFDSRDLLGFVDGTENPTGRGAVGAALIDT
                     SGEPEFAGGSYVIVQKYVHDMAAWHALSTEEQEHVIGRTKLDDVELDEEVMPTNSHVSL
                     NTIVDEDGTEHDILRDNMAFGDPGRGEFGTYYIAYAADPSVTEQMLDNMFIGNPPGNYD
                     HILDVSTALTGSLFFVPSLD"
     CDS             complement(5277..6617)
                     /locus_tag="ctg263_7"
                     /transl_table=11
                     /translation="MARHRVVIIGSGFGGLFATRALRRSDVDITVIARTGHHLFQPLLY
                     QVATGILSEGEIAPATREVLRRQRNARVLLGLVEDIDTQARVVHWRNHNRAEETPYDTL
                     VVAAGAGQSYFGNDHFATFAPGMKTIDDALELRARIFGAFELAEIETDPTRIAELLTFV
                     VVGAGPTGVEMAGQIRELSSNTLRGEFRSIDPSSARVVLLDGAPLPLPVFGEKLGTRAQ
                     KALEELGVEVRTRTLVTGMDAESVTVRDAEGKSERIPSVCKVWAAGVQGSPLGRVLAER
                     TGAELDRAGRVRVGPDLSVPGHPEVFVIGDLMSVDGVPGVAQGAIQSARFVADLIDSRL
                     RGRRPCRTTFSYRDKGSMATIARFKAVVSVGRVKMSGFTAWLAWCFLHLLYIVGFKQQV
                     MTLLHWFISFLSRARSERTTTNQQMVARLALERLGEHSSGRLVTGEE"
     PFAM_domain     complement(5631..6608)
                     /aSDomain="Pyr_redox_2"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF07992.16"
                     /description="Pyridine nucleotide-disulphide
                     oxidoreductase"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg263_7_0008"
                     /evalue="4.10E-49"
                     /label="ctg263_7"
                     /locus_tag="ctg263_7"
                     /protein_end="329"
                     /protein_start="3"
                     /score="167.5"
                     /tool="antismash"
                     /translation="HRVVIIGSGFGGLFATRALRRSDVDITVIARTGHHLFQPLLYQVA
                     TGILSEGEIAPATREVLRRQRNARVLLGLVEDIDTQARVVHWRNHNRAEETPYDTLVVA
                     AGAGQSYFGNDHFATFAPGMKTIDDALELRARIFGAFELAEIETDPTRIAELLTFVVVG
                     AGPTGVEMAGQIRELSSNTLRGEFRSIDPSSARVVLLDGAPLPLPVFGEKLGTRAQKAL
                     EELGVEVRTRTLVTGMDAESVTVRDAEGKSERIPSVCKVWAAGVQGSPLGRVLAERTGA
                     ELDRAGRVRVGPDLSVPGHPEVFVIGDLMSVDGVPGVAQGAIQSA"
     CDS             complement(7026..7784)
                     /locus_tag="ctg263_8"
                     /transl_table=11
                     /translation="MSASLVVLASGIGSLLVTIPRQRRAPLSWAWTALCLVLGVAGLGV
                     QWWACLALVGVAQGWCLSIGAAAPGAPRRGMPAAVGRAPHRTIVATACLVVTIAVALGL
                     ETVLTTGPTALTRGWTEVRSPALAGVPLALLVATVGVIALMGPASNLLTASTLAAVRGT
                     EGATPPDQPVLRGGRVIGPLERLLIVVLGLAGALPVIAALLAAKGIVRFPEISRDSGLG
                     AKAEEFLIGSMTSWSLACAAALFLALLRGA"
     CDS             complement(7781..7999)
                     /locus_tag="ctg263_9"
                     /transl_table=11
                     /translation="VNALLLLRDHVIARMKSRERRIATGLLAGSTQVEIARSEGITQSA
                     VSQNAHRSGAATLVEVHRLLASGEVRR"
     CDS             complement(7996..8451)
                     /locus_tag="ctg263_10"
                     /transl_table=11
                     /translation="MTIATGIIADIIGSRDLPDRAAAQQAILDSLARACEGAEVLRPVW
                     PTVGDEFQLVVADPPTAVRVTGLAHLLLPATLSLRFGIGTGTVVEVGGSTTGSAPPIQD
                     GSAWWAAREAIQTVHRLRRGARTPPSPGSAAVPPPARGRRRGPRRRR"
     PFAM_domain     complement(8092..8433)
                     /aSDomain="SatD"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF16264.7"
                     /description="SatD family (SatD)"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg263_10_0009"
                     /evalue="1.50E-10"
                     /label="ctg263_10"
                     /locus_tag="ctg263_10"
                     /protein_end="120"
                     /protein_start="6"
                     /score="41.2"
                     /tool="antismash"
                     /translation="IIADIIGSRDLPDRAAAQQAILDSLARACEGAEVLRPVWPTVGDE
                     FQLVVADPPTAVRVTGLAHLLLPATLSLRFGIGTGTVVEVGGSTTGSAPPIQDGSAWWA
                     AREAIQTVHR"
ORIGIN
        1 cccctgccgg cgggcgccgc tgggttccga ccggcaggca ccgggggccc cggtcagcac
       61 gtgccgctga caaccggcca ggagaggggg tccgggcgcc gtgcccggac ccctccctcg
      121 actcctgcgc tccacgtgcg gcttctcaca cagggccggt cctcgtggga cgaacagcgt
      181 ggacggacaa tggcaggaac ggaaggacac acatggacgc ccagcagcag agcgaccggg
      241 gaccggggcg cgtggcaccg accacgttcg cggagaacga gacgatccgc acccaactcg
      301 cccaccgcac gatccgtgcg ttcacccccg accccgtggg ggaggaggtc gtccgcagcc
      361 tgttggacgt cgcccggcac gcccccacga gcagcttcta ccagcagacg accgtcctgt
      421 gggtcaggga tcccgtcctg cggcacgagg tgtaccggtc ctccggacag ccctacgtgg
      481 acgggacccg gggcgagctg ctggtgttcg tcgtggacct gcaccgcaac gcctgcatcc
      541 gggaggaggc gggtgaggac ctcgaaccac tcggacgcac gaccctgttc ctcgagggcg
      601 tcgaggacgc ggtcatcgcg gcccagaaca ccgtcgtggc cgccgagagc ctcggcctgg
      661 gcaccgtcta cctggggagc atcggcggcg acccgcggcg tgtcatccgc gcgctgcggc
      721 tcccacggca caccttcccc ctcctcggtc tcctggtcgg gcaccccgac caggagcccc
      781 agttcaagcc ccgtctcccc gccgacctga ccacggcggt cgacacctat cccgaggtcg
      841 aggactgggg tgccgccctg gccgggtacg acgcgaccgt gcagacctac tacgacctcc
      901 gcgacgcgaa ccgcagggtg gactccttca cccaccagat ccgcaccaag cccgggaccg
      961 gacgcgcaga acaggccccc gtcctcgagg tgctgcacga gcagggactg gcgctgggct
     1021 gagggcgggt cccggagcca cacgtccagg acccggggcc gatgaaacgc tgatatcgct
     1081 cggatatcag gagaagtgtg cggcccccgc gcccccaccg tcgcgtccga ttcccgccag
     1141 ccgaacgggc ggcaccatgg caggctgtgg cccatggact tcgactcccg ctacgccgca
     1201 gtcgcgtccc gtgaccgacg gttcgacgga cgcttcgtca ccgcggtgcg ctcgacgggg
     1261 atctactgcc gcccgagctg cccggcccgc acgccgaagc ccggcaacgt cgagttcttc
     1321 gccaccagcg cggcagccca ggccgcaggg taccgggcct gccggagatg cctgcccgag
     1381 gccctgcccg gcagccccga gtgggacctg cgcgaggacc tggcggcccg cgcgatgcga
     1441 ctgatcagcc agggagtcgt cgaccgcgaa ggcgtcggcg gtctcgcgtc ccggctcggg
     1501 cactccaccc gtcacctgac gcgcgtgctc accgacgagc tcggtgcagg tccgctcgcc
     1561 ctggcgcgct cacagcgcgc ccacaccgcc cggcagctcc tgtgcaccac gacactgccg
     1621 gtctccgagg tggccttctc cgcggggttc tccagcatcc gccagttcaa tgacaccgtc
     1681 cgcgaggtct tcggcctcac ccccacccag ctgcgcgggc gcgcccgacg cgcggaggcg
     1741 gtcgcccagg tacccggggc gatcacgctg cgcctggcac accgtgagcc gctggacctg
     1801 cgtggtctgt tcgactggta tgccgcgcgc gccgtccggg gcatcgagga cgcaggaggc
     1861 ggacacctct cacggacgct gaggacgtcg cgcggcgccg ccctcgtcga actgtggggg
     1921 gagggcaggg aggtcctggc acgactccac ctgcaggatc cctccgagct ccccgaagtg
     1981 ctcggacggg ttcggcgagc actcgacctc gatgcggacc ccgtctccgt cgacaccgcc
     2041 ctgtcccgtg atgaccggct cgccccacac gtcgacgaag tgccggggat ccgcatcccc
     2101 ggtgagttcg acctcgcaga ggctttggtg cgcgccgtga tcggacagca ggtgggggtg
     2161 gaacccgccc gcagggactt cgcccgggtg gcgcgtctgc tggcggatcc cctcccccgg
     2221 ggttcgcacc cgcggggcgg aaggacgcca cgccccatct cctgttcccc accgcgtccg
     2281 tcctggccga gcgcgccgtc gcggctgtac ccgggccgcg acgccggggg gccacgatcg
     2341 cggcggcctg tgcggcggtc gcggaggggc gcctcgccat cgacccctcc tggagacgtg
     2401 aggacgcggt ggcggccctg tgtgcggtgc cggggatcgg cccgtggacc gcggaccacg
     2461 tgacgatgcg cgtgacgggg aacccggacg tcctggtccg tggcgacgcc gcgcagtgga
     2521 ggggtgcgag caggctcggg ttgggcacca cagctgcgga actggaaggg gaggggcgtg
     2581 cattcgcgcc ctggaggagc tacctcggca tgcacctgtg gcgtgcctcg atcggaaggg
     2641 acacaccatg acggacgtcg gacaccctgc ggcggaggcg ggacacctcg ccgggctgct
     2701 gctcgtgacg actctcggga cacccgacgg gcccttcacc gtggtggagg agacggacgg
     2761 aaccgtctgg gcctccggat ggagcgcgga tgtcggggac ctcctgcacc gcgcacacat
     2821 cgcccccggg acaccgctgg cgccctcccg gggaccctcg gctgcggtac gcgcggtcct
     2881 ctccctctac gagggcgacg ccgcacccct ggccggtgtc ccggtccgcc ggtccggcac
     2941 cgcgttccaa caggaggtgt ggaggggact gcgggacatc ccggtgggga cgacactctc
     3001 ctacagccgg ctcggggagt gcatcggccg ccctcgtgcg gttcgcgccg tcggcctggc
     3061 ctgcgggcgc aacgccgtgg cccccttcgt gccctgccac cgcgtggtgg gggccgacgg
     3121 ttcactgacc ggttacgcgt gggggctcga ggtcaagcgc cacctcctga ccctcgaggg
     3181 cgcgctgcgt ccctgagggg gcggcacccc tgccggtacg gaaccgtccg tcccggcagg
     3241 ggtcacgccc tggaggggtt gacgggcgtt ccccgacggc gggggagcgg tctcagggac
     3301 ggacgaggac gaccgaggcc tcgtcggtgt gggtgaggaa ggtcagggac tcctggaggt
     3361 agagctcgac gtcctcaccc gtgtgggagg tgtagccgat cgagacatcc tgtcccagga
     3421 ccatctcgta gtcgccgccg cgcgtgctca acaggcagcc acccgacagg gccggcgccc
     3481 agacgacctg ttcgacgagc tgctccagct gcgtgcggat ggggtagccg tggtcgcggg
     3541 tctccgaggc ctcggtgtgg acgtcggcgt cgaggaccag ggcgtagggg ccctccaccc
     3601 cggccaaccg cagctcggtg agggcgtggg cgaccacctc ggggagctcc cgcgcatcgg
     3661 cgggcagggt gatcggttca ttgctcgagg ccggggcgat gccccggacc tgcgcggcgg
     3721 cgtacccctg gaagacggcg gcgtcctcgg ccctggccag tgcggtggcg gcgtccttga
     3781 cgggctgcca gtcggagtcc tgcgcgcccc ggaggacgtc gtcgacggcg gcacgcgaga
     3841 ccgagaaggg gacgcgcagc tcgaccagtg gggcgacctc ccgcagacgc gagcggatgc
     3901 ccggccgggg cgggtcgatg gtgctcaggt ggccggtgtt ggcggcggcc gcctccaggc
     3961 cgagagggcc cgtgacgtcg acgacgcgac gtgcggcgga gttgcgacgg aaggtgcgcc
     4021 gcgcctcctc ggcgatctcg ccccaggcgg cgtcactgac gggcgcgagc caacggtgca
     4081 ggttggaggt cccgaccgtg gtcgccgtcg cggcgaccgt gggcccttcg ttcggtgagc
     4141 tcatgatgtg gttcctctca ggctgccgat cgacagcgat tccgtggtgc tggtgtcggg
     4201 ttcggtgtcc ggtcgtcctg ctgcgggtcg tccctgtgcg ggcacgtcgt ccgggagcga
     4261 ctccaacagg tccagtgagg gcacgaagaa cagggagccg gtcagggccg tggacacgtc
     4321 gaggatgtgg tcgtagttgc ccggtgggtt gccgatgaac atgttgtcga gcatctgctc
     4381 ggtgacggag ggatccgcgg cgtaggcgat gtagtacgtg ccgaactccc cacgacccgg
     4441 gtcgccgaag gccatgttgt cacgcaggat gtcgtgctcg gtgccgtcct cgtcgacgat
     4501 ggtgttgagg gagacgtggg agttggtcgg catgacctcc tcgtcgagct cgacgtcgtc
     4561 gagcttcgtg cgaccgatga cgtgctcctg ctcctcggtg ctcagtgcgt gccaggcggc
     4621 catgtcgtgc acgtacttct gcacgatgac gtagctgcca ccggcgaact ccggttcacc
     4681 ggaggtgtcg atcagggcgg cacccactgc cccacgcccg gtcgggttct cggtgccgtc
     4741 gacgaacccg aggaggtccc gggagtcgaa gtaacggaag ccggtgacgt ggtcctcgac
     4801 gtgcacgtcc gcaccgatgg cgtccatcag aagccgggtc agctcgaaga cgaggtcggg
     4861 ccggttcgcg cggatgtgga agaggatgtc cccgggggtg gagggtgcgt tgtgacgggc
     4921 ccccgtcacg gggtggaagg cgtggagctg ggcgggtcgg ggggtcccgg cgggtcggat
     4981 cctgtcccag aagtccgccc cgaaccccac cacgcaggac agggaggcgg tgggttcgcg
     5041 gaagccgacg gcccggacga gcgaaccgat gtcggctgcc accgcgagga cgcgtcccgc
     5101 tgcggaggag tccccgggga cggtgacgac gaggaaggcc gccgaggagg tcagcgaggt
     5161 gaggatcgcc tggggctccg ggtcctgggc cggggtctgg ggcgactggg cactctggaa
     5221 ggcatcgagg ggcacacccc gagcctaccg ccccgggtgg ccgggcggag gcggcctcac
     5281 tcctctccgg tcaccagcct gcccgaggag tgctccccga ggcgctccag tgccagacgt
     5341 gccaccatct gctggttcgt ggtggtgcgt tccgagcgtg cccgggagag gaagctgatg
     5401 aaccagtgca gcagggtcat gacctgctgt ttgaaaccga cgatgtagag caggtgcagg
     5461 aagcaccacg ccagccaggc cgtgaaccca ctcatcttga cccgaccgac gctgaccacc
     5521 gccttgaaac gtgcgatcgt ggccatcgac cccttgtccc ggtagctgaa ggtggtcctg
     5581 cagggtcgtc gtccacgcag gcgcgagtcg atgaggtccg cgacgaaacg tgctgactga
     5641 atggcaccct gggcgacccc ggggacaccg tcgacggaca tgaggtctcc gatgacgaag
     5701 acctcgggat ggccgggcac cgacaggtcc gggccgaccc tcacccggcc cgcccggtcc
     5761 agctcggctc cggtgcgctc ggcgagcacg cggcccaggg gggagccctg gacaccggcc
     5821 gcccacacct tgcacaccga ggggatgcgt tcgctcttcc cctcggcgtc gcgcaccgtg
     5881 accgactcgg cgtccatgcc ggtgaccagg gtgcgggtac ggacctcgac accgagctcc
     5941 tccagggcct tctgggcgcg ggtgcccagc ttctcgccga acaccggcag gggcaggggc
     6001 gctccgtcga gcaggaccac gcgggcgctt gagggatcga tggagcggaa ctcaccgcgc
     6061 agcgtgttgg aggagagctc ccggatctgt cccgccatct ccacaccggt cggacccgcc
     6121 cccacgacca cgaaggtgag gagttccgcg atccgggtgg ggtcggtctc gatctcggcg
     6181 agttcgaagg ctccgaagat cctcgcacgc agttcgaggg cgtcgtcgat ggtcttcatc
     6241 ccgggggcga aggtcgcgaa atggtcattg ccgaagtagg actgtccggc tcccgcggcg
     6301 acgaccaggg tgtcgtaggg ggtctcctcg gcccggttgt ggttcctcca gtgcacgacc
     6361 cgcgcctgtg tgtcgatgtc ctccacgagg cccaggagga cccgcgcgtt gcgctgcctg
     6421 cgcaggacct cgcgggtcgc gggtgcgatc tccccctcgg agaggattcc cgtggcgacc
     6481 tggtagagga gtggttggaa caggtggtgg cccgtccgcg cgatgacggt gatgtcgacg
     6541 tcgctgcgcc gcagcgcccg cgtggcgaac agtcccccga agccggagcc gatgatgacg
     6601 acgcgatgcc tggccatggt tcctcccgaa ataggtcagg tgaatgttac ctaattcgtg
     6661 gggcggatcc cagcggggga ggggtgcctg cacctgacgg gggtcgcggt ggtggaggat
     6721 ccgccgacgg gtgcgggatc tgggggggtg gcggggacgt gcggaggaat gtgggacgtg
     6781 cggacggtgc ggggcgtgcg gaggaatgcg ggacgtggtg aggtcaggag cgctgggcgg
     6841 gcgtggcccc gcacccgggg aaccctctgc gcgagggccg cgttccgtga ccgccccgtg
     6901 tacggctcca gggcgccctt cacgcgtcac cggccgacgt ggacagcccg cggcccggcc
     6961 cgacgtgtcc gcctccgcgt gtccgaccgg tgggacgccc gtggaggact cccacgggga
     7021 ggcagtcacg cacccctgag cagggcgagg aacagggcgg ccgcgcaggc cagcgaccag
     7081 ctcgtcatcg atccgatgag gaactcctcg gccttcgccc cgagtcccga gtcccgtgag
     7141 atctccggga aacgcacgat gcccttggcg gccaggagtg cggcgatcac cgggagcgca
     7201 ccggcgagcc cgagcaccac gatgaggagg cgttcgaggg ggccgatgac acgacctccc
     7261 cgcagtaccg gttggtcggg aggggttgcc ccctccgtgc ctcgcaccgc tgcgagggtc
     7321 gatgccgtga ggaggttgga ggcggggccc atgagggcga tcaccccgac cgtggcgacc
     7381 aggagtgcca gggggacccc ggccagggcg ggtgagcgca cctccgtcca ccctcgggtg
     7441 agagcggtgg ggcccgtcgt caggacggtt tccaggccga gcgccacggc gatggtgacg
     7501 accagacagg cggtcgcgac gatggtccgg tgcggggccc gaccgacggc cgcgggcatg
     7561 ccacgacgtg gtgcgcccgg agctgctgcc ccgatggaca ggcaccaccc ctgcgcgacg
     7621 cccaccaggg cgaggcaggc ccaccactgc acgccgaggc cggccactcc caggaccagg
     7681 cacagtgcgg tccacgccca ggacaggggg gcgcggcgct gccgggggat cgtgacgagg
     7741 agggaaccga tgcccgaggc gaggacgacg agtgaggcgc tcatcggcgc acctccccgg
     7801 aggcgaggag tcggtggacc tcgaccaatg tcgcggcgcc cgatcggtgc gcattctggg
     7861 agacggccga ctgggtgatc ccttcggagc gtgcgatctc gacctgggtc gacccggcca
     7921 ggagtccggt ggcgatgcgg cgctcccggg acttcatgcg ggcgatcacg tggtcgcgca
     7981 gcagcaggag ggcgttcacc gtctcctcct cgggccacgc cgcctgcccc gggctggagg
     8041 gggcaccgct gcggaaccag gtgagggcgg cgtcctggcc cccctgcgga gccggtggac
     8101 ggtctggatc gcctcccgcg ccgcccacca ggcggagccg tcctggatgg gcggggccga
     8161 cccggtggtg ctgccaccca cctccaccac ggtgccggtg ccgatcccga accggagcga
     8221 gagcgtcgcc gggagcagga ggtgcgcgag acccgtcacc cgtacggcgg tgggcggatc
     8281 ggcgacgacc aattggaact cgtcgccgac cgtcggccag accggacgca gcacctcggc
     8341 gccctcgcag gcccgcgcca gggagtcgag gatggcctgc tgggcagcgg cacggtcggg
     8401 caggtcgcgg gagccgatga tgtccgcgat gatgccggtg gcgatggtca tgcctgacga
     8461 taacactgat atgtgcccaa tatcagtgtt tttgtggacc cagcccagtc acacaccact
     8521 gtcctcgagc acgaaggcag gggagggcac ctgcgccgac ccctccagga gccggggacg
     8581 ggggttctgc ggggtccgtt ccaggacacg gaccagcgag tccgtctccc cggcgacgac
     8641 gaggagactc cggccgtcgc ccgcgtccac cacggcgaag tggcggggcc aggacgtccc
     8701 cgtccaggcc cgacccagca gctccaggcc actgccgtcg gaggagacgc ggaacgtggc
     8761 gagactcccg ggtccacgca cggccacgtc gagcaggagc gtcccgtccg gctgcggtga
     8821 gagcaccagg tgcgagggca ggggtgcgtc gtccgagcgg tcggccacgg gcacccgcgt
     8881 cacctcgtgg gcctccttcc cgccccactc ctggagcacc acctcggcgc tgagctcggt
     8941 gacgacgagg aggtgacgcc cgtccggcag gaatgctgcg tggcgtggtc cggatccggg
     9001 ggtgaaacgg aatgccactc cgtcctcgac cagctggggt gacccgcccc cctcgacgac
     9061 gcgcagccgc ctcagctcat cggtgcccag gtcgcacacg aggacggtcc ccgcgcccgg
     9121 ggcgaccgtc gcggagtgtg catg
//
