LOCUS       c00001_NZ_UHFZ..       10297 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  NZ_UHFZ01000003.1 Streptococcus parasanguinis strain NCTC12854,
            whole genome shotgun sequence.
ACCESSION   NZ_UHFZ01000003
VERSION     NZ_UHFZ01000003
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 6.1.1
            Run date     :: 2024-03-14 16:18:13
            Original ID  :: NZ_UHFZ01000003.1
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 394180
            Orig. end    :: 404477
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..10297
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[399180:399477](-)"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193)"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(5001..5297)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193)"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
     cand_cluster    1..10297
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193)"
                     /kind="single"
                     /product="RiPP-like"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..10297
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="RiPP-like"
                     /region_number="1"
                     /rules="(strepbact or Antimicrobial14 or Bacteriocin_IId or
                     BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or
                     Lactococcin or Antimicrobial17 or Lactococcin_972 or
                     Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or
                     TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or
                     TIGR03975 or DUF692 or TIGR01193)"
                     /tool="antismash"
     CDS             complement(1575..1937)
                     /locus_tag="ctg1_377"
                     /transl_table=11
                     /translation="MRKIVSILLLSLSIITLIACTKNKQQSLDGEYYWISSERNELAFT
                     IKGDNASIEHGEANSFTINKKKNTIELTGQNIASRTEEYSFKDGVFSVDISGVKHDYYL
                     KDSEEYNNALKQYGYK"
     CDS             complement(2284..2919)
                     /gene_functions="transport (smcogs) SMCOG1000:ABC
                     transporter ATP-binding protein (Score: 187.5; E-value:
                     4.9e-57)"
                     /gene_kind="transport"
                     /locus_tag="ctg1_378"
                     /transl_table=11
                     /translation="MIKIHQLTKTFGDRTVFSDLNLNFDAGKVYALIGNSGCGKTTLLN
                     MVAKLEPYDQGSIQYKGKDLRKIKPTNYFRNELGYLFQNFGLIDNNTVSENLDLGLIGH
                     KLDKQKKRETKEEVLDRVGLSYIQLDQKVYELSGGEAQRVALAKIILKDPPLILADELT
                     AALDPETSQEIMDLLLTLKNKERLIIIATHNPTIWKQADQVVSLKNSQ"
     aSDomain        complement(2299..2910)
                     /aSDomain="TIGR03608"
                     /aSTool="tigrfam"
                     /description="L_ocin_972_ABC: putative bacteriocin export
                     ABC transporter, lactococcin 972 group"
                     /detection="hmmscan"
                     /domain_id="TIGRFam_ctg1_378_0001"
                     /evalue="4.30E-82"
                     /identifier="TIGR03608"
                     /label="ctg1_378"
                     /locus_tag="ctg1_378"
                     /protein_end="207"
                     /protein_start="3"
                     /score="272.5"
                     /tool="antismash"
                     /translation="IHQLTKTFGDRTVFSDLNLNFDAGKVYALIGNSGCGKTTLLNMVA
                     KLEPYDQGSIQYKGKDLRKIKPTNYFRNELGYLFQNFGLIDNNTVSENLDLGLIGHKLD
                     KQKKRETKEEVLDRVGLSYIQLDQKVYELSGGEAQRVALAKIILKDPPLILADELTAAL
                     DPETSQEIMDLLLTLKNKERLIIIATHNPTIWKQADQVVSL"
     PFAM_domain     complement(2428..2868)
                     /aSDomain="ABC_tran"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00005.29"
                     /description="ABC transporter"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_378_0001"
                     /evalue="1.70E-32"
                     /label="ctg1_378"
                     /locus_tag="ctg1_378"
                     /protein_end="164"
                     /protein_start="17"
                     /score="112.9"
                     /tool="antismash"
                     /translation="SDLNLNFDAGKVYALIGNSGCGKTTLLNMVAKLEPYDQGSIQYKG
                     KDLRKIKPTNYFRNELGYLFQNFGLIDNNTVSENLDLGLIGHKLDKQKKRETKEEVLDR
                     VGLSYIQLDQKVYELSGGEAQRVALAKIILKDPPLILADELTA"
     CDS             complement(2922..4934)
                     /locus_tag="ctg1_379"
                     /transl_table=11
                     /translation="MKRFFVILSNIFITSFLLWICFSTSNLVIHNSFPAIGILSQNKEV
                     SKDQVKYSLDQLANETDSVIGQQIEKIDDKGKVHFSYAIYGSGHIPNGLVKASKEDFYN
                     SSLFVNYYILSGNLTLDRLNHELQSLGFTETFVSYPNIFLSLFTFMGNGTQLLILVIFL
                     LTFIALMIIQKTKEMRTVGIRYISGLHLTQIFGNSMISDCGDLLLGVITGIFLGICGVS
                     LFHITPFSIPVIFSASITYNLLLLFLSILFSFLYVLSIKAVHLVSLLKGKLPLKQIMGI
                     LYLGQLVAFLLIVLTIHRTSIYSTIWQLHQSGDTAWSNQKDWVLLSTNREFGSEIRNQD
                     SRKMLEEQWKNFIETGIQNGGMLVQHPFASFDLKGLSSHPLTGEKMSINDYNPYANSLY
                     VTPNYLDVQNVELNEEDKKSINSLGEGEFGLLLPEKLKDQEDKLRQIYEDFLAIRNDKE
                     NKIQQAMKARVFYISNNKKRFVYNSTPISYQQFLSDPILIVLKPSSFGKNQNAFFTYPS
                     DYLYFKGLDATKKLVEQGGIKRYISQYDLAYYVYRGMSHNIQVEILTIIAGGFLGIATS
                     ILLFNTMTILYFEEFRKTILIKKISGLNFFELHQKFFIWQIVIFILGGAIGLLLTNKLW
                     VVFLTSCVFGLNSILILMHRSRKEDRMASIILKGA"
     PFAM_domain     complement(2928..3224)
                     /aSDomain="DUF1430"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF07242.13"
                     /description="Protein of unknown function (DUF1430)"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_379_0002"
                     /evalue="8.80E-21"
                     /label="ctg1_379"
                     /locus_tag="ctg1_379"
                     /protein_end="669"
                     /protein_start="570"
                     /score="74.1"
                     /tool="antismash"
                     /translation="LGIATSILLFNTMTILYFEEFRKTILIKKISGLNFFELHQKFFIW
                     QIVIFILGGAIGLLLTNKLWVVFLTSCVFGLNSILILMHRSRKEDRMASIILKG"
     aSDomain        complement(2928..4934)
                     /aSDomain="TIGR01654"
                     /aSTool="tigrfam"
                     /description="bact_immun_7tm: bacteriocin-associated
                     integral membrane protein"
                     /detection="hmmscan"
                     /domain_id="TIGRFam_ctg1_379_0002"
                     /evalue="1.30E-82"
                     /identifier="TIGR01654"
                     /label="ctg1_379"
                     /locus_tag="ctg1_379"
                     /protein_end="669"
                     /protein_start="0"
                     /score="276.3"
                     /tool="antismash"
                     /translation="MKRFFVILSNIFITSFLLWICFSTSNLVIHNSFPAIGILSQNKEV
                     SKDQVKYSLDQLANETDSVIGQQIEKIDDKGKVHFSYAIYGSGHIPNGLVKASKEDFYN
                     SSLFVNYYILSGNLTLDRLNHELQSLGFTETFVSYPNIFLSLFTFMGNGTQLLILVIFL
                     LTFIALMIIQKTKEMRTVGIRYISGLHLTQIFGNSMISDCGDLLLGVITGIFLGICGVS
                     LFHITPFSIPVIFSASITYNLLLLFLSILFSFLYVLSIKAVHLVSLLKGKLPLKQIMGI
                     LYLGQLVAFLLIVLTIHRTSIYSTIWQLHQSGDTAWSNQKDWVLLSTNREFGSEIRNQD
                     SRKMLEEQWKNFIETGIQNGGMLVQHPFASFDLKGLSSHPLTGEKMSINDYNPYANSLY
                     VTPNYLDVQNVELNEEDKKSINSLGEGEFGLLLPEKLKDQEDKLRQIYEDFLAIRNDKE
                     NKIQQAMKARVFYISNNKKRFVYNSTPISYQQFLSDPILIVLKPSSFGKNQNAFFTYPS
                     DYLYFKGLDATKKLVEQGGIKRYISQYDLAYYVYRGMSHNIQVEILTIIAGGFLGIATS
                     ILLFNTMTILYFEEFRKTILIKKISGLNFFELHQKFFIWQIVIFILGGAIGLLLTNKLW
                     VVFLTSCVFGLNSILILMHRSRKEDRMASIILKG"
     CDS             complement(5001..5297)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: Lactococcin_972"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg1_380"
                     /sec_met_domain="Lactococcin_972 (E-value: 1.2e-11,
                     bitscore: 41.9, seeds: 6, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKFYKIFLTSLTIVISCCLICPVFADWVSGGVWSYGANHDPNNWG
                     AFSNYYHDYQYHWSSVTRARDSKSKYGTAPAHQTSKAFINTNLGEVAYFNYGF"
     aSDomain        complement(5004..5216)
                     /aSDomain="TIGR01653"
                     /aSTool="tigrfam"
                     /description="lactococcin_972: bacteriocin, lactococcin 972
                     family"
                     /detection="hmmscan"
                     /domain_id="TIGRFam_ctg1_380_0003"
                     /evalue="3.60E-10"
                     /identifier="TIGR01653"
                     /label="ctg1_380"
                     /locus_tag="ctg1_380"
                     /protein_end="98"
                     /protein_start="27"
                     /score="38.0"
                     /tool="antismash"
                     /translation="VSGGVWSYGANHDPNNWGAFSNYYHDYQYHWSSVTRARDSKSKYG
                     TAPAHQTSKAFINTNLGEVAYFNYGF"
     PFAM_domain     complement(5031..5213)
                     /aSDomain="Lactococcin_972"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF09683.12"
                     /description="Bacteriocin (Lactococcin_972)"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_380_0003"
                     /evalue="2.60E-10"
                     /label="ctg1_380"
                     /locus_tag="ctg1_380"
                     /protein_end="89"
                     /protein_start="28"
                     /score="40.7"
                     /tool="antismash"
                     /translation="SGGVWSYGANHDPNNWGAFSNYYHDYQYHWSSVTRARDSKSKYGT
                     APAHQTSKAFINTNLG"
     CDS             5662..6510
                     /locus_tag="ctg1_381"
                     /transl_table=11
                     /translation="MRWDYGTIYKKIRKSKHISQEEVCQGYISRAHLSRIESNQVVPSF
                     ESMEHLLKQVGLDFEEFRYICHSYHHSDREEIILLAEDNNAYQSNDKLLELKNKSVAYL
                     KKHPNDIPVLNILKRVEVILCLRESGPNEKVRMMATEAWNEIKNQDVWYHSDLKLIVVI
                     LFTLPLETVISICDEVIDRLNDYSDYTEILPTKYKLLSNLASIFLWNGLMEKCTSISYL
                     LLDTAKKSKRYDFLGNAKVTLGICLSDKKLVDEGLQLLELTDEITLLEACRSDVNRFFK
                     E"
     PFAM_domain     5689..5847
                     /aSDomain="HTH_3"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF01381.24"
                     /description="Helix-turn-helix"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_381_0004"
                     /evalue="2.80E-06"
                     /label="ctg1_381"
                     /locus_tag="ctg1_381"
                     /protein_end="62"
                     /protein_start="9"
                     /score="27.4"
                     /tool="antismash"
                     /translation="KKIRKSKHISQEEVCQGYISRAHLSRIESNQVVPSFESMEHLLKQ
                     VGLDFEEF"
     CDS             complement(6716..7327)
                     /locus_tag="ctg1_382"
                     /transl_table=11
                     /translation="LVKNQYEGYEYIDPNHQYTYPNSTVLINKQNVTNIEEAYRNEHLF
                     VTKRLADLRLKAIKVYSMSNILAIHNYLFQDVYAWSGQYRKVNISKSGNPFMSIQSFNA
                     AETYINHLIHSYHQTANSRDEIIKHLAKILDNLNYFHPFREGNGRTQREVIRSLALSKG
                     YSAQIRVEQDDEIYNLYMDGTVYGELWKLEKLFDKILKEI"
     PFAM_domain     complement(6860..7138)
                     /aSDomain="Fic"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF02661.20"
                     /description="Fic/DOC family"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_382_0005"
                     /evalue="3.40E-17"
                     /label="ctg1_382"
                     /locus_tag="ctg1_382"
                     /protein_end="156"
                     /protein_start="63"
                     /score="63.2"
                     /tool="antismash"
                     /translation="SNILAIHNYLFQDVYAWSGQYRKVNISKSGNPFMSIQSFNAAETY
                     INHLIHSYHQTANSRDEIIKHLAKILDNLNYFHPFREGNGRTQREVIR"
     CDS             complement(7320..7508)
                     /locus_tag="ctg1_383"
                     /transl_table=11
                     /translation="MTLDVNKEELTILGIPFDNFSDFDTVWYAIGSSMIENYEPTVQDV
                     IDLKTYVINKRKELNIG"
     CDS             8448..8666
                     /locus_tag="ctg1_384"
                     /transl_table=11
                     /translation="MVNMKLKNRLKELRARDGLNQTELAKLAGISRQTISLLERDEYTP
                     SIIIALKISQIFHEPVESVFRLEEEES"
     PFAM_domain     8475..8627
                     /aSDomain="HTH_3"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF01381.24"
                     /description="Helix-turn-helix"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_384_0006"
                     /evalue="1.40E-13"
                     /label="ctg1_384"
                     /locus_tag="ctg1_384"
                     /protein_end="60"
                     /protein_start="9"
                     /score="50.8"
                     /tool="antismash"
                     /translation="LKELRARDGLNQTELAKLAGISRQTISLLERDEYTPSIIIALKIS
                     QIFHEP"
     CDS             8663..8851
                     /locus_tag="ctg1_385"
                     /transl_table=11
                     /translation="MNKYRVIYYLCIIAFVANVSMMIGTLLGWFHILDSNYFFWSSLIF
                     SLVFERIEKKVKEREKV"
     CDS             8865..9215
                     /locus_tag="ctg1_386"
                     /transl_table=11
                     /translation="MKEFLADFQVDTEHKEIAGVCAGIANYFNIDPLMIRALACLLFLS
                     SIEISLLTVISYAFLAGWMGNESLEVVIKKSGYKILFFYLVAILLNSFGDQVLTATFGF
                     GHALVQGLLGLF"
     PFAM_domain     8898..9056
                     /aSDomain="PspC"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF04024.14"
                     /description="PspC domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_386_0007"
                     /evalue="7.70E-11"
                     /label="ctg1_386"
                     /locus_tag="ctg1_386"
                     /protein_end="64"
                     /protein_start="11"
                     /score="41.8"
                     /tool="antismash"
                     /translation="TEHKEIAGVCAGIANYFNIDPLMIRALACLLFLSSIEISLLTVIS
                     YAFLAGWM"
     CDS             9230..9931
                     /locus_tag="ctg1_387"
                     /transl_table=11
                     /translation="MKKKHLLLLLGSLLLGGLIGMFGVAFTNLHLNISQEQVQFILTTI
                     FFCLGILSTIVALYFIMNSRKVYASYLAEEDDELNELAYIKMYRSLDYGTVAYNVLQVS
                     MLFSLLTVLPSHDLPISAFLLAVLTILVGSFCIKTTSKIRNYQLSILATPKEVLDYLET
                     YDEGEKQAEMEEAYLILFKLNQLILPSVYIILFALSIILGEVQLVAALITAVIHLYINI
                     AQLRKTKRYFK"
     PFAM_domain     9239..9910
                     /aSDomain="DUF3169"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF11368.10"
                     /description="Protein of unknown function (DUF3169)"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_387_0008"
                     /evalue="3.30E-24"
                     /label="ctg1_387"
                     /locus_tag="ctg1_387"
                     /protein_end="227"
                     /protein_start="3"
                     /score="85.9"
                     /tool="antismash"
                     /translation="KHLLLLLGSLLLGGLIGMFGVAFTNLHLNISQEQVQFILTTIFFC
                     LGILSTIVALYFIMNSRKVYASYLAEEDDELNELAYIKMYRSLDYGTVAYNVLQVSMLF
                     SLLTVLPSHDLPISAFLLAVLTILVGSFCIKTTSKIRNYQLSILATPKEVLDYLETYDE
                     GEKQAEMEEAYLILFKLNQLILPSVYIILFALSIILGEVQLVAALITAVIHLYINIAQL
                     RK"
ORIGIN
        1 ctgtttctcc taattcaaat ctagatattt gagattttga aatttcagca cctgctaatg
       61 aagaaataga aattcccttt tcttctctta ttttcctata agtttcacct aaaatcatat
      121 ttatctccat ttaccataaa aaatcattag aaagcgtgac agattatgaa aaaatactat
      181 caaatctttt tattattatt atttgatatt atcattatta ttggattata tcaataaaat
      241 taatgagtgt gtgaaaattc aatactagga gaaaatgaaa taaatatttc cacaataaaa
      301 agtatgatat caagtttttt ggaaagcctc tgtttgtaaa ttattttaac tcacagttga
      361 tgattccaca aattgaaaag ttttaaactt agcatttaaa cgctcaattt taatacgtat
      421 tacaactatc tctattaaac ttcttatcct ctacagtcga tacatgcttt ttagaacttt
      481 ttaaaggaaa aaagatatct catgaatatt catagtatct aaataacaaa aacaagtaat
      541 tgctctgaca aacttgacct atactttctt taaaaagagt aaaatcatgt gtatgaccgt
      601 ctcaaaaaac taattgacag gcacgaagtg tcgttaaatc gattatgatt gtgtctttat
      661 ggtgtatatc tttttccagg ataattctta ctttggtttc ttttaggaca ttgaaatagg
      721 actttctgtg acatcaatag ctatagtgac acttgttaat tttaagtttt ctaagtcaaa
      781 tagacttgag gaatgaagag tgtattctac gaatgttaat gttcactagt ccaagaccaa
      841 aatcaaaaaa ctagaagatg ttgagttgat taatagcata aataatgcaa gttcagaatt
      901 aactgttttt ctagacttaa agtttttgtg cctcctcctt tacagtgttt ggatttataa
      961 gttgtatcta gacaggatat ctttgttggg aaggtatcct ttttgacact aataaataat
     1021 ttaaagttct caggagttag ttgcatggtt tttcgtaaat agttttctta actatagtat
     1081 agcatagtac agtatggcac tttatttttt ccaataagtc tattataccc caaggacagc
     1141 tggttttaat tttttctctg aactgtacga ttttgcgcca gaaatgtagg aattaccttt
     1201 cgttgtgatg tgataaaact tacaaatctt ttttgttatt cttgacctag ttttttagaa
     1261 agaaggtcta agatgttaaa taaagtcaaa actaaagcct taattagtgt tggagcagtg
     1321 gctgcaacta gctttattct ctgaatcttg catgataaga agaataaaga aataaaaaga
     1381 aaaatcaaag tgtttgttta tcggcaatca tcacaattcg gttttttaaa ataggatggt
     1441 atattttgtt tctttgacca aaatttgaac aaaaaataga tttgactttc ggttaataat
     1501 aagcttaaaa gttttttgaa ggaatctatt tagcacaaaa aaacacctat tcgggaaaat
     1561 aggtgtgaat gatgttattt atatccatat tgttttagtg cgttattata ttcttcgcta
     1621 tctttaagat agtagtcgtg cttaactcca ctaatatcaa cagaaaagac cccatcttta
     1681 aatgaatatt cttctgttcg acttgcaata ttttgtccag ttaattcgat cgtattcttt
     1741 tttttgttaa tggtaaagct gttggcttct ccatgctcta tggaagcatt atctccttta
     1801 atagtaaatg ccaattcatt tctttcactt gatatccaat agtattcgcc atccagagat
     1861 tgttgcttat ttttagtgca agcaattaac gtaattattg ataatgacaa caataatatg
     1921 ctaacaattt ttctcatgtt tctcgcctcc ttttataata ttactatacc aaaataatgt
     1981 tacaaaactg tatcaatgtc tgttataatg gaaatttcaa acaatgtcca ttataacaga
     2041 cattagtaaa ttatagaaaa agatctatat ttggctatag ttttactaaa tctctacgac
     2101 tatagattaa aaatgtatac acttctatac aaatagtaga aaaggactca gtcctgtgca
     2161 atacagaact aaatcctttg gataaattat taatctaact atttgggtgc acttaacttt
     2221 cgggatgttt tgtcaggaaa tgaatatgta acgtaatgaa aatctgtgct attaccctat
     2281 tcttcattga ctatttttta ggcttaccac ttgatcagct tgtttccaaa tggttggatt
     2341 atgtgttgca ataatgatca gacgttcctt attttttaat gttaggagta agtccataat
     2401 ctcctgtgag gtctcaggat caagagcggc agttaattca tctgccaaaa ttagaggagg
     2461 atcttttaaa atgatctttg ccaaggctac acgttgtgct tctcctcccg aaagctcata
     2521 tactttttga tctagttgaa tataagatag tcctactcta tctaatactt cttctttagt
     2581 ctctctcttt ttttgtttgt ctaatttatg accaattaat cccaaatcta aattttctga
     2641 aacagtatta ttatcgatta gtccaaaatt ctggaagaga taacctagtt catttctgaa
     2701 atagtttgtt ggtttaatct ttcgtaaatc tttcccttta tattgaatac tcccctgatc
     2761 ataaggttct agcttggcta ccatatttag taaggttgtt ttgccacaac cactatttcc
     2821 gataagagca tagactttac ctgcatcaaa atttaagttc aaatcactaa ataccgtccg
     2881 gtccccaaag gtttttgtta gttgatggat tttaatcatt tctatgctcc tttcaatata
     2941 atactagcca tcctatcttc cttacgagaa cgatgcatta gtattaaaat agaattcaaa
     3001 ccaaagacgc aagaggttag aaagactacc caaagtttat ttgttagcaa aagaccaata
     3061 gcccctccca aaatgaagat aactatttgc cagataaaaa atttctggtg taactcaaaa
     3121 aaatttaatc ctgatatttt cttaataaga atagttttac gaaattcttc aaagtagagg
     3181 attgtcattg tattaaagag tagaattgag gtagcaatac cgagaaaacc accagcaatg
     3241 attgtcaata tttcaacttg aatgttgtga ctcataccac gataaacata ataggcaaga
     3301 tcatactgac tgatatatct ctttattcca ccttgttcaa ctagtttttt agtggcatcc
     3361 aaacctttaa aatacagata atcagatgga taagtgaaga aagcattttg attttttcca
     3421 aaagagcttg gtttaaggac aataagtata ggatcactta gaaattgttg atatgagatt
     3481 ggtgtagaat tatatacgaa acgcttctta ttgtttgaaa tatagaaaac acgagctttc
     3541 atagcctgtt gaattttatt ttccttatcg tttcgaatcg ctaggaaatc ttcataaatt
     3601 tgacgcaatt tatcttcttg atcttttaat ttttcaggca atagtagtcc aaattctcct
     3661 tctccaaggc tattaatgct cttcttatct tcttcattta attctacatt ctgaacatct
     3721 aaataattag gagtcacata taagctatta gcatacggat tgtagtcatt tatcgacatt
     3781 ttttctcccg ttaagggatg tgaagacaga ccttttagat cgaatgatgc aaatggatgc
     3841 tgaacaagca ttcctccatt ctgaatgcca gtttctatga agtttttcca ttgttcttcc
     3901 aacatttttc tactatcctg atttctaatc tctgacccaa actccctatt tgttgaaagc
     3961 aatacccaat ctttttgatt tgaccatgct gtatctccag actgatgcaa ttgccaaata
     4021 gttgaataga tacttgttct atgaatggta agtactatta aaagaaaagc gaccaattgc
     4081 cccaagtaaa gaatacccat aatctgtttc aaaggtaact ttcctttgag taaagaaacc
     4141 aaatgtaccg ctttaatact taaaacataa agaaagctaa agagtataga aaggaacaaa
     4201 agtaacaaat tataagttat gctagctgaa aaaataactg gaatagaaaa tggtgtgata
     4261 tggaatagac ttacaccaca gattccaaga aaaatccctg taattacccc taaaagtaaa
     4321 tctccacaat cactaatcat tgagtttcca aaaatctgag ttaggtgcaa tccagaaata
     4381 tatcgaatcc caactgttcg catttccttg gttttttgaa taatcattaa ggctataaaa
     4441 gttagtagaa aaatgaccaa aatgagtaat tgagtaccat ttcccataaa cgtaaataag
     4501 ctaagaaaaa tatttggata tgaaacaaat gtttctgtga aacccaatga ttgaagttca
     4561 tgatttaatc tatctagagt gagatttcca gataaaatat aataattgac aaataagcta
     4621 ctattgtaaa aatcttcttt actagcttta acaaggccat ttgggatatg gccagatcca
     4681 tatattgcat aggaaaaatg aaccttacct ttatcatcta ttttttcaat ttgttgacca
     4741 atcacactgt ctgtttcatt tgctaattga tctaaactgt attttacctg atcttttgat
     4801 acctctttgt tctgggaaag aataccaata gctggaaaac tattgtgaat aaccagattt
     4861 gaggttgaaa aacaaatcca aagtagaaaa cttgttataa agatatttga aaggataaca
     4921 aagaagcgct tcatacttta ctcactttct aaaactttca tggatagtaa tataatcttt
     4981 tctatgagct atgaattttt ttaaaatccg taattaaaat atgctacttc acccaaattt
     5041 gtatttataa aagcttttga ggtctgatga gcaggagcgg taccatattt tgatttacta
     5101 tctcttgcac gagttacgct tgaccagtga tattggtaat catggtaata atttgaaaat
     5161 gcaccccagt tatttggatc gtgattagca ccataactcc atacaccacc agaaacccaa
     5221 tctgcaaaaa ccggacaaat taaacaacaa ctaataacaa tagttaaaga agttaaaaat
     5281 atcttataaa atttcattat taaatacctc ctaaacctat atttataatt taataactta
     5341 tttgttttag attacttaat ctgggacctc ctttcatatt actatccatg aaattctcaa
     5401 caatttatac ataagggcta tcaaaaatat ttatgataaa attagatatt atcttacaat
     5461 tctaatctca tttctattaa tgaaatcccc accatctcca aatgtctaac aagttaaaga
     5521 gtgggagtga tgctacaaaa aataaataaa tagtgatttt tttcatgttt ttcacctctt
     5581 tctttatata tatgatatac taaacacata tcgaaatgta aaaatgtcac atatatacac
     5641 ataattagag gtggagtttt tatgcgttgg gattacggta cgatctataa aaaaatacgg
     5701 aaatcaaaac atattagtca agaggaagtt tgccagggtt acatttcaag agcgcattta
     5761 tcacgtattg aatcgaacca agtggtaccg agttttgagt cgatggagca tcttctaaag
     5821 caagttggct tagatttcga agaatttcga tatatatgcc attcttacca ccactccgat
     5881 agggaagaaa ttatcttatt agcggaagat aacaatgcct accaatcaaa tgataaatta
     5941 ttggaactga agaataagag tgtagcttat ttaaaaaaac atcctaatga tattcctgtg
     6001 ttaaatatac taaagagagt agaggtcatt ctttgtttac gagaatctgg tccaaatgaa
     6061 aaggtaagaa tgatggcaac ggaagcttgg aacgaaatca aaaatcagga tgtctggtat
     6121 catagtgacc taaaattaat tgtcgttatt ttatttacac ttccactaga aacagtgatt
     6181 tctatctgtg atgaagtgat agataggctc aatgattact ctgattatac agagattctt
     6241 cccaccaagt ataaattact ctcaaattta gctagcattt ttctgtggaa tggtttgatg
     6301 gagaagtgta cgagtatcag ttatctattg ttagatacgg ccaaaaaaag taagcgatat
     6361 gattttctag gaaatgctaa agtgacactt ggaatttgtt taagtgataa aaagctagtt
     6421 gatgaaggct tgcagttact cgaattaact gatgaaataa cgttgttgga agcatgtagg
     6481 tcagatgtga atcgtttttt caaggaatga gtttctaatt aagaatcgta gaaaaaggca
     6541 aagtttcttc gatggataac gatgaatgtt ttgccatctt aaaaagctag agtttgaatt
     6601 gaaatacagt acaatagttc gcatttggca aaaagaaaaa agcctttgaa atcaacgttt
     6661 caatggcttt tagcttaata aatttttttc ttctgtaatt atcaagtatt acaacctata
     6721 tttcttttaa tattttatca aataattttt ctaatttcca taattctcca tagacagttc
     6781 cgtccatata aaggttgtaa atttcatcat cttgttccac tcgtatttgt gcagaatacc
     6841 cttttgatag tgctaaggaa cgaataactt cccgttgagt tcgtccatta ccttctcgaa
     6901 agggatggaa ataattaaga ttatcaagaa tttttgctaa atgtttaatg atttcatctc
     6961 ttgagttggc agtttgatga taggaatgaa tgagatgatt tatataagtt tccgcagcat
     7021 taaacgactg tatcgacata aaaggattac cacttttaga gatattcacc ttgcgatatt
     7081 gtcctgacca agcataaaca tcttgaaaca aatagttatg aatggctaaa atattactca
     7141 tggaatagac tttaatggct ttcaagcgca aatctgcaag tcttttagta acgaataagt
     7201 gttcatttcg gtaggcttct tcaatatttg taacattttg tttattgatt aagactgtgg
     7261 aatttggata ggtatattgg tgattggggt caatatactc atagccttcg tattgatttt
     7321 taaccaatat tcaattcctt tcgtttgttg ataacataag tttttaaatc aatcacatct
     7381 tgaacagtag gttcataatt ttcaatcatt gatgacccaa tagcatacca gacggtatcg
     7441 aaatctgaaa agttatcaaa gggaatccct aaaattgtta attcttcttt atttacatca
     7501 agagtcatgg cacacttcct tgtataacgt tatctttatt ataccataaa atcggtattt
     7561 ttacctaaaa ggatagagac caaaagatat atgtaagcgt atagattaat acttacagaa
     7621 ctaaaaatat tcccctgttt ttagtccaac tgaaacccat actttccaaa ccaggtctta
     7681 agaaaaaagg tagagaaaaa ggtagagttt gaattgaaat acagtgcaat atatcgcatt
     7741 tggcaaaaag aaaaaacgct tgaaatcagc gtttttcttc tgtattgatt cgtattgaac
     7801 ccctacttca cttctgtaaa aaccaaataa ggtaaacttt tgatattctg gttcgatttt
     7861 atcttatttt taatgaaagt ttaccttatt taaatgaaag tgattgaaat taattgaaat
     7921 tttaattctt agaaacttat gaaaatgttg attttaaagc attttgaaat tggataaaat
     7981 aagtggtgcc ccaaccaggt cttaagaaag cacgtaaagc ttcacaattc tcaaaacgtt
     8041 aatcaatacg attatatcaa cgtttacaga cattcaagag aactctcttg gatgtctttt
     8101 ttgtttcaaa aatacaaagt tcaccctaaa attcacctta taccttttgt gatgttaagc
     8161 cttcatattg tcactgttta gagaaatgct ctaagccatt ttgaatcaga atgagcaact
     8221 tgacttaaat tgtttacaaa atgacaaaaa taatgatatt tttgactaat atcattgtca
     8281 aaaataaaaa gatatgttac aatgtaatca agttaaagaa ataagaactt agatagggag
     8341 gaactatgtg tgcatcgtta atactatctt atttaatagc aaaggaggaa agatcaaatt
     8401 ctaccgtttt taggctatct aagccaagtg gttgaatttg atagacaatg gtaaatatga
     8461 agctaaaaaa tcgtttaaaa gagcttcgcg ctcgtgatgg tttaaaccaa accgagcttg
     8521 caaagctagc aggtatatcg aggcagacta ttagtttgct agagcgtgat gagtataccc
     8581 cctctattat tattgccttg aaaatctctc agatatttca tgagccagta gagtcggtat
     8641 ttcgcttaga ggaggaagaa tcatgaacaa atatagagta atttattatc tttgtatcat
     8701 tgcctttgta gcaaatgttt cgatgatgat cgggaccttg ctgggatggt ttcacatttt
     8761 agacagtaat tattttttct ggagtagctt gatttttagt ttagtatttg agcggataga
     8821 aaagaaagta aaagaaagag aaaaagtata aaaggagtaa gattatgaaa gagtttttgg
     8881 cagattttca agtagatacc gaacacaaag aaattgcagg ggtttgtgcc ggtatagcta
     8941 attatttcaa tatagaccct ctgatgattc gtgcactggc ttgtttgctt tttctatctt
     9001 cgatagaaat tagtcttctc acagtgataa gttatgcttt tttagctggc tggatgggaa
     9061 atgaatctct tgaagtagtc atcaaaaaat cagggtacaa gattctattt ttctatctag
     9121 ttgccattct cctgaatagt tttggtgatc aagttttaac ggctactttt gggtttgggc
     9181 atgctctggt tcaaggactg ctaggtttat tttagaaaga agatagaaaa tgaaaaagaa
     9241 acatttatta ctattgttag gaagtttatt gttgggtggt ttaatcggaa tgtttggtgt
     9301 tgcctttacg aatcttcatt taaacatttc tcaagagcaa gtacagttta ttttgacgac
     9361 catctttttc tgtctgggaa tactatcgac aatagtagct ctctatttta tcatgaatag
     9421 taggaaagtt tatgctagct acctagcaga agaagatgat gaattaaacg agctagctta
     9481 tatcaagatg tatcgctctc tagattatgg gacagttgct tacaatgttt tgcaagttag
     9541 tatgcttttt agcttgctta cagtgttgcc tagccacgat ttaccgatat cagcttttct
     9601 cttagcagta ttaaccattc ttgttggaag tttctgcatc aaaacaacga gcaaaattcg
     9661 taattaccaa ctttctattt tagccacacc aaaagaggta ttagattatc tagaaaccta
     9721 tgacgaggga gagaaacaag cggaaatgga agaggcttat ttaatcttgt tcaaactcaa
     9781 tcagctaatc ttaccatctg tctatatcat cttgtttgcc ctatccatta ttcttggaga
     9841 agtacagtta gttgctgccc ttattactgc tgtcatccat ctctacatca atattgcaca
     9901 attaagaaaa acaaaacgtt actttaaata acagggattt ctatgaatcg tgtcgcaaat
     9961 gtaggtgacg atgttgaaag gaatgaatca atcaaaataa atttcattcc aagatagagc
    10021 taaacataaa attctaaaaa gtttgtaaag tagctttagt aaacgttctt ttaaaagaat
    10081 gctaatcatt acaatgagca cccttcgggg tgttcttttt gtataactga atttgaagca
    10141 aataaaaacc caccccatct tccacagtca aatgcgactg tagaaaatag agtgggacta
    10201 ggatgttaag gcttagttgt cgtctttgtg aaagatattt ttaacgccct tgatagctcc
    10261 ttcaacagct tcttttgcat cttcagcaac ttctttt
//
