LOCUS       c00003_NZ_UHFZ..        9724 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  NZ_UHFZ01000001.1 Streptococcus parasanguinis strain NCTC12854,
            whole genome shotgun sequence.
ACCESSION   NZ_UHFZ01000001
VERSION     NZ_UHFZ01000001
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 6.1.1
            Run date     :: 2024-03-14 16:18:13
            Original ID  :: NZ_UHFZ01000001.1
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 9724
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..9724
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="True"
                     /core_location="[4427:4724](-)"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193)"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(4428..4724)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193)"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
     cand_cluster    1..9724
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193)"
                     /kind="single"
                     /product="RiPP-like"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..9724
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="RiPP-like"
                     /region_number="1"
                     /rules="(strepbact or Antimicrobial14 or Bacteriocin_IId or
                     BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or
                     Lactococcin or Antimicrobial17 or Lactococcin_972 or
                     Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or
                     TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or
                     TIGR03975 or DUF692 or TIGR01193)"
                     /tool="antismash"
     CDS             complement(296..472)
                     /locus_tag="ctg3_1"
                     /transl_table=11
                     /translation="MQLTPENFKLFISVKKDTFPTKISCLDTTYKSKHCKGGGTKTLSL
                     EKQLILNLHYLCY"
     CDS             complement(1000..1362)
                     /locus_tag="ctg3_2"
                     /transl_table=11
                     /translation="MRKIVSILLLSLSIITLIACTKNKQQSLDGEYYWISSERNELAFT
                     IKGDNASIEHGEANSFTINKKKNTIELTGQNIASRTEEYSFKDGVFSVDISGVKHDYYL
                     KDSEEYNNALKQYGYK"
     CDS             complement(1709..2344)
                     /gene_functions="transport (smcogs) SMCOG1000:ABC
                     transporter ATP-binding protein (Score: 187.5; E-value:
                     4.9e-57)"
                     /gene_kind="transport"
                     /locus_tag="ctg3_3"
                     /transl_table=11
                     /translation="MIKIHQLTKTFGDRTVFSDLNLNFDAGKVYALIGNSGCGKTTLLN
                     MVAKLEPYDQGSIQYKGKDLRKIKPTNYFRNELGYLFQNFGLIDNNTVSENLDLGLIGH
                     KLDKQKKRETKEEVLDRVGLSYIQLDQKVYELSGGEAQRVALAKIILKDPPLILADELT
                     AALDPETSQEIMDLLLTLKNKERLIIIATHNPTIWKQADQVVSLKNSQ"
     aSDomain        complement(1724..2335)
                     /aSDomain="TIGR03608"
                     /aSTool="tigrfam"
                     /description="L_ocin_972_ABC: putative bacteriocin export
                     ABC transporter, lactococcin 972 group"
                     /detection="hmmscan"
                     /domain_id="TIGRFam_ctg3_3_0001"
                     /evalue="4.30E-82"
                     /identifier="TIGR03608"
                     /label="ctg3_3"
                     /locus_tag="ctg3_3"
                     /protein_end="207"
                     /protein_start="3"
                     /score="272.5"
                     /tool="antismash"
                     /translation="IHQLTKTFGDRTVFSDLNLNFDAGKVYALIGNSGCGKTTLLNMVA
                     KLEPYDQGSIQYKGKDLRKIKPTNYFRNELGYLFQNFGLIDNNTVSENLDLGLIGHKLD
                     KQKKRETKEEVLDRVGLSYIQLDQKVYELSGGEAQRVALAKIILKDPPLILADELTAAL
                     DPETSQEIMDLLLTLKNKERLIIIATHNPTIWKQADQVVSL"
     PFAM_domain     complement(1853..2293)
                     /aSDomain="ABC_tran"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00005.29"
                     /description="ABC transporter"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg3_3_0001"
                     /evalue="1.70E-32"
                     /label="ctg3_3"
                     /locus_tag="ctg3_3"
                     /protein_end="164"
                     /protein_start="17"
                     /score="112.9"
                     /tool="antismash"
                     /translation="SDLNLNFDAGKVYALIGNSGCGKTTLLNMVAKLEPYDQGSIQYKG
                     KDLRKIKPTNYFRNELGYLFQNFGLIDNNTVSENLDLGLIGHKLDKQKKRETKEEVLDR
                     VGLSYIQLDQKVYELSGGEAQRVALAKIILKDPPLILADELTA"
     CDS             complement(2347..3624)
                     /locus_tag="ctg3_4"
                     /transl_table=11
                     /translation="LFLSILFSFLYVLSIKAVHLVSLLKGKLPLKQIMGILYLGQLVAF
                     LLIVLTIHRTSIYSTIWQLHQSGDTAWSNQKDWVLLSTNREFGSEIRNQDSRKMLEEQW
                     KNFIETGIQNGGMLVQHPFCIIRSKRSVFTSLNGEKMSINDYNPYANSLYVTPNYLDVQ
                     NVELNEEDKKSINSLGEGEFGLLLPEKLKDQEDKLRQIYEDFLAIRNDKENKIQQAMKA
                     RVFYISNNKKRFVYNSTPISYQQFLSDPILIVLKPSSFGKNQNAFFTYPSDYLYFKGLD
                     ATKKLVEQGGIKRYISQYDLAYYVYRGMSHNIQVEILTIIAGGFLGIATSILLFNTMTI
                     LYFEEFRKTILIKKISGLNFFELHQKFFIWQIVIFILGGAIGLLLTNKLWVVFLTSCVF
                     GLNSILILMHRSRKEDRMASIILKGA"
     PFAM_domain     complement(2353..2649)
                     /aSDomain="DUF1430"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF07242.13"
                     /description="Protein of unknown function (DUF1430)"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg3_4_0002"
                     /evalue="4.20E-21"
                     /label="ctg3_4"
                     /locus_tag="ctg3_4"
                     /protein_end="424"
                     /protein_start="325"
                     /score="75.2"
                     /tool="antismash"
                     /translation="LGIATSILLFNTMTILYFEEFRKTILIKKISGLNFFELHQKFFIW
                     QIVIFILGGAIGLLLTNKLWVVFLTSCVFGLNSILILMHRSRKEDRMASIILKG"
     aSDomain        complement(2353..3624)
                     /aSDomain="TIGR01654"
                     /aSTool="tigrfam"
                     /description="bact_immun_7tm: bacteriocin-associated
                     integral membrane protein"
                     /detection="hmmscan"
                     /domain_id="TIGRFam_ctg3_4_0002"
                     /evalue="3.50E-63"
                     /identifier="TIGR01654"
                     /label="ctg3_4"
                     /locus_tag="ctg3_4"
                     /protein_end="424"
                     /protein_start="0"
                     /score="212.1"
                     /tool="antismash"
                     /translation="LFLSILFSFLYVLSIKAVHLVSLLKGKLPLKQIMGILYLGQLVAF
                     LLIVLTIHRTSIYSTIWQLHQSGDTAWSNQKDWVLLSTNREFGSEIRNQDSRKMLEEQW
                     KNFIETGIQNGGMLVQHPFCIIRSKRSVFTSLNGEKMSINDYNPYANSLYVTPNYLDVQ
                     NVELNEEDKKSINSLGEGEFGLLLPEKLKDQEDKLRQIYEDFLAIRNDKENKIQQAMKA
                     RVFYISNNKKRFVYNSTPISYQQFLSDPILIVLKPSSFGKNQNAFFTYPSDYLYFKGLD
                     ATKKLVEQGGIKRYISQYDLAYYVYRGMSHNIQVEILTIIAGGFLGIATSILLFNTMTI
                     LYFEEFRKTILIKKISGLNFFELHQKFFIWQIVIFILGGAIGLLLTNKLWVVFLTSCVF
                     GLNSILILMHRSRKEDRMASIILKG"
     CDS             complement(3759..4361)
                     /locus_tag="ctg3_5"
                     /transl_table=11
                     /translation="MKRFFVILSNIFITSFLLWICFSTSNLVIHNSFPAIGILSQNKEV
                     SKDQVKYSLDQLANETDSVIGQQIEKIDDKGKVHFSYAIYGSGHIPNGLVKASKEDFYN
                     SSLFVNYYILSGNLTLDRLNHELQSLGFTETFVSYPNIFLSLFTFMGNGTQLLILVIFS
                     TNFYSLNDYSKNQGNANSWDSIYFWIAPNSDFWKLND"
     CDS             complement(4428..4724)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: Lactococcin_972"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg3_6"
                     /sec_met_domain="Lactococcin_972 (E-value: 1.1e-13,
                     bitscore: 41.9, seeds: 6, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKFYKIFLTSLTIVISCCLICPVFADWVSGGVWSYGANHDPNNWG
                     AFSNYYHDYQYHWSSVTRARDSKSKYGTAPAHQTSKAFINTNLGEVAYFNYGF"
     aSDomain        complement(4431..4643)
                     /aSDomain="TIGR01653"
                     /aSTool="tigrfam"
                     /description="lactococcin_972: bacteriocin, lactococcin 972
                     family"
                     /detection="hmmscan"
                     /domain_id="TIGRFam_ctg3_6_0003"
                     /evalue="3.60E-10"
                     /identifier="TIGR01653"
                     /label="ctg3_6"
                     /locus_tag="ctg3_6"
                     /protein_end="98"
                     /protein_start="27"
                     /score="38.0"
                     /tool="antismash"
                     /translation="VSGGVWSYGANHDPNNWGAFSNYYHDYQYHWSSVTRARDSKSKYG
                     TAPAHQTSKAFINTNLGEVAYFNYGF"
     PFAM_domain     complement(4458..4640)
                     /aSDomain="Lactococcin_972"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF09683.12"
                     /description="Bacteriocin (Lactococcin_972)"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg3_6_0003"
                     /evalue="2.60E-10"
                     /label="ctg3_6"
                     /locus_tag="ctg3_6"
                     /protein_end="89"
                     /protein_start="28"
                     /score="40.7"
                     /tool="antismash"
                     /translation="SGGVWSYGANHDPNNWGAFSNYYHDYQYHWSSVTRARDSKSKYGT
                     APAHQTSKAFINTNLG"
     CDS             complement(4941..5069)
                     /locus_tag="ctg3_7"
                     /transl_table=11
                     /translation="MCIYVTFLHFDMCLVYHIYKERGEKHEKNHYLFIFCSITPTL"
     CDS             5089..5937
                     /locus_tag="ctg3_8"
                     /transl_table=11
                     /translation="MRWDYGTIYKKIRKSKHISQEEVCQGYISRAHLSRIESNQVVPSF
                     ESMEHLLKQVGLDFEEFRYICHSYHHSDREEIILLAEDNNAYQSNDKLLELKNKSVAYL
                     KKHPNDIPVLNILKRVEVILCLRESGPNEKVRMMATEAWNEIKNQDVWYHSDLKLIVVI
                     LFTLPLETVISICDEVIDRLNDYSDYTEILPTKYKLLSNLASIFLWNGLMEKCTSISYL
                     LLDTAKKSKRYDFLGNAKVTLGICLSDKKLVDEGLQLLELTDEITLLEACRSDVNRFFK
                     E"
     PFAM_domain     5116..5274
                     /aSDomain="HTH_3"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF01381.24"
                     /description="Helix-turn-helix"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg3_8_0004"
                     /evalue="2.80E-06"
                     /label="ctg3_8"
                     /locus_tag="ctg3_8"
                     /protein_end="62"
                     /protein_start="9"
                     /score="27.4"
                     /tool="antismash"
                     /translation="KKIRKSKHISQEEVCQGYISRAHLSRIESNQVVPSFESMEHLLKQ
                     VGLDFEEF"
     CDS             complement(6143..6754)
                     /locus_tag="ctg3_9"
                     /transl_table=11
                     /translation="LVKNQYEGYEYIDPNHQYTYPNSTVLINKQNVTNIEEAYRNEHLF
                     VTKRLADLRLKAIKVYSMSNILAIHNYLFQDVYAWSGQYRKVNISKSGNPFMSIQSFNA
                     AETYINHLIHSYHQTANSRDEIIKHLAKILDNLNYFHPFREGNGRTQREVIRSLALSKG
                     YSAQIRVEQDDEIYNLYMDGTVYGELWKLEKLFDKILKEI"
     PFAM_domain     complement(6287..6565)
                     /aSDomain="Fic"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF02661.20"
                     /description="Fic/DOC family"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg3_9_0005"
                     /evalue="3.40E-17"
                     /label="ctg3_9"
                     /locus_tag="ctg3_9"
                     /protein_end="156"
                     /protein_start="63"
                     /score="63.2"
                     /tool="antismash"
                     /translation="SNILAIHNYLFQDVYAWSGQYRKVNISKSGNPFMSIQSFNAAETY
                     INHLIHSYHQTANSRDEIIKHLAKILDNLNYFHPFREGNGRTQREVIR"
     CDS             complement(6747..6935)
                     /locus_tag="ctg3_10"
                     /transl_table=11
                     /translation="MTLDVNKEELTILGIPFDNFSDFDTVWYAIGSSMIENYEPTVQDV
                     IDLKTYVINKRKELNIG"
     CDS             7259..7408
                     /locus_tag="ctg3_11"
                     /transl_table=11
                     /translation="MLTKLILTAFTTVYEEKVEKKVEFQMTVNFHLLFVKVVPLKYRLL
                     HSFG"
     CDS             complement(7341..8612)
                     /gene_functions="other (smcogs) SMCOG1077:phage integrase
                     family protein (Score: 135.2; E-value: 6.6e-41)"
                     /gene_kind="other"
                     /locus_tag="ctg3_12"
                     /transl_table=11
                     /translation="MQIETIERNNKKVLKKIKKDGSITYSMKGAYLGTDKKTGKQVTTT
                     ISAPTLKALDRKYLETKRKFEENDSTRKETLSVGTIKELSEFWYDSYKSWVSSDNTRNR
                     VRGYLDTYILPKFGDYKIDSIESTEVQKWVDQLAEKARIEINKGKRKADKGKASDYGAV
                     VHKLKDILDFGMVHFNLKNNPAKQVRIPPKPKAPQNRIQVLHEKDIAIWLNYLDTLPNS
                     RANRRFKLICNTLLASALRINELLALEVDDLLFESSEINVNKTLMWRRGDKTLGTKGKV
                     ICKNSAKTDSGNRKVSVPITIIQELKDFNNEMNNYFEKHGLPKSKLIFPTIYGNYMTDR
                     NERATLIKRLKELGLPDYGFHLFRHTHASLMLNSGANWKELQERMGHKSISTTMDIYAE
                     LDPNRKNEAVDILMERLSQIKGEN"
     PFAM_domain     complement(7410..8003)
                     /aSDomain="Phage_integrase"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00589.24"
                     /description="Phage integrase family"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg3_12_0007"
                     /evalue="4.80E-23"
                     /label="ctg3_12"
                     /locus_tag="ctg3_12"
                     /protein_end="401"
                     /protein_start="203"
                     /score="81.9"
                     /tool="antismash"
                     /translation="LHEKDIAIWLNYLDTLPNSRANRRFKLICNTLLASALRINELLAL
                     EVDDLLFESSEINVNKTLMWRRGDKTLGTKGKVICKNSAKTDSGNRKVSVPITIIQELK
                     DFNNEMNNYFEKHGLPKSKLIFPTIYGNYMTDRNERATLIKRLKELGLPDYGFHLFRHT
                     HASLMLNSGANWKELQERMGHKSISTTMDIYAELD"
     PFAM_domain     complement(8202..8375)
                     /aSDomain="Phage_int_SAM_3"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF14659.8"
                     /description="Phage integrase, N-terminal SAM-like domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg3_12_0006"
                     /evalue="1.70E-10"
                     /label="ctg3_12"
                     /locus_tag="ctg3_12"
                     /protein_end="137"
                     /protein_start="79"
                     /score="41.1"
                     /tool="antismash"
                     /translation="TIKELSEFWYDSYKSWVSSDNTRNRVRGYLDTYILPKFGDYKIDS
                     IESTEVQKWVDQL"
     CDS             complement(8623..8880)
                     /locus_tag="ctg3_13"
                     /transl_table=11
                     /translation="MDTLQQVKLDKIENLLQVLVNLLDKRSDTNQLEIMTQKEVLKELN
                     ISPNTLKSWERKGLPRLEPPIEGTRTVYYKRGDILKFLTI"
     PFAM_domain     complement(8626..8778)
                     /aSDomain="MerR_1"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF13411.8"
                     /description="MerR HTH family regulatory protein"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg3_13_0008"
                     /evalue="9.50E-08"
                     /label="ctg3_13"
                     /locus_tag="ctg3_13"
                     /protein_end="85"
                     /protein_start="34"
                     /score="32.1"
                     /tool="antismash"
                     /translation="MTQKEVLKELNISPNTLKSWERKGLPRLEPPIEGTRTVYYKRGDI
                     LKFLTI"
     CDS             complement(8894..9130)
                     /locus_tag="ctg3_14"
                     /transl_table=11
                     /translation="MNKPGFTTTHTPTEHSALSFSPGQAGADPIYGHISFVEQVKSDGS
                     ILVSECNVKGLGIISYRTFDAETAKQFTYVIGH"
     PFAM_domain     complement(8975..9112)
                     /aSDomain="CHAP"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF05257.18"
                     /description="CHAP domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg3_14_0009"
                     /evalue="6.20E-06"
                     /label="ctg3_14"
                     /locus_tag="ctg3_14"
                     /protein_end="52"
                     /protein_start="6"
                     /score="26.8"
                     /tool="antismash"
                     /translation="TTTHTPTEHSALSFSPGQAGADPIYGHISFVEQVKSDGSILVSEC
                     N"
ORIGIN
        1 aagagtaaaa tcatgtgtat gaccgtctca aaaaactaat tgacaggcac gaagtgtcgt
       61 taaatcgatt atgattgtgt ctttatggtg tatatctttt tccaggataa ttcttacttt
      121 ggtttctttt aggacattga aataggactt tctgtgacat caatagctat agtgacactt
      181 gttaatttta agttttctaa gtcaaataga cttgaggaat gaagagtgta ttctacgaat
      241 gttaatgttc actagtccaa gaccaaaatc aaaaaactag aagatgttga gttgattaat
      301 agcataaata atgcaagttc agaattaact gtttttctag acttaaagtt tttgtgcctc
      361 ctcctttaca gtgtttggat ttataagttg tatctagaca ggatatcttt gttgggaagg
      421 tatccttttt gacactaata aataatttaa agttctcagg agttagttgc atggtttttc
      481 gtaaatagtt ttcttaacta tagtatagca tagtacagta tggcacttta ttttttccaa
      541 taagtctatt ataccccaag gacagctggt tttaattttt tctctgaact gtacgatttt
      601 gcgccagaaa tgtaggaatt acctttcgtt gtgatgtgat aaaacttaca aatctttttt
      661 gttattcttg acctagtttt ttagaaagaa ggtctaagat gttaaataaa gtcaaaacta
      721 aagccttaat tagtgttgga gcagtggctg caactagctt tattctctga atcttgcatg
      781 ataagaagaa taaagaaata aaaagaaaaa tcaaagtgtt tgtttatcgg caatcatcac
      841 aattcggttt tttaaaatag gatggtattt ttgtttcttt gaccaaaatt tgaacaaaaa
      901 atagatttga ctttcggtta ataataagct taaaagtttt ttgaaggaat ctatttagca
      961 caaaaaaaca cctattcggg aaaataggtg tgaatgatgt tatttatatc catattgttt
     1021 tagtgcgtta ttatattctt cgctatcttt aagatagtag tcgtgcttaa ctccactaat
     1081 atcaacagaa aagaccccat ctttaaatga atattcttct gttcgacttg caatattttg
     1141 tccagttaat tcgatcgtat tctttttttt gttaatggta aagctgttgg cttctccatg
     1201 ctctatggaa gcattatctc ctttaatagt aaatgccaat tcatttcttt cacttgatat
     1261 ccaatagtat tcgccatcca gagattgttg cttattttta gtgcaagcaa ttaacgtaat
     1321 tattgataat gacaacaata atatgctaac aatttttctc atgtttctcg cctcctttta
     1381 taatattact ataccaaaat aatgttacaa aactgtatca atgtctgtta taatggaaat
     1441 ttcaaacaat gtccattata acagacatta gtaaattata gaaaaagatc tatatttggc
     1501 tatagtttta ctaaatctct acgactatag attaaaaatg tatacacttc tatacaaata
     1561 gtagaaaagg actcagtcct gtgcaataca gaactaaatc ctttggataa attattaatc
     1621 taactatttg ggtgcactta actttcggga tgttttgtca ggaaatgaat atgtaacgta
     1681 atgaaaatct gtgctattac cctattcttc attgactatt ttttaggctt accacttgat
     1741 cagcttgttt ccaaatggtt ggattatgtg ttgcaataat gatcagacgt tccttatttt
     1801 ttaatgttag gagtaagtcc ataatctcct gtgaggtctc aggatcaaga gcggcagtta
     1861 attcatctgc caaaattaga ggaggatctt ttaaaatgat ctttgccaag gctacacgtt
     1921 gtgcttctcc tcccgaaagc tcatatactt tttgatctag ttgaatataa gatagtccta
     1981 ctctatctaa tacttcttct ttagtctctc tctttttttg tttgtctaat ttatgaccaa
     2041 ttaatcccaa atctaaattt tctgaaacag tattattatc gattagtcca aaattctgga
     2101 agagataacc tagttcattt ctgaaatagt ttgttggttt aatctttcgt aaatctttcc
     2161 ctttatattg aatactcccc tgatcataag gttctagctt ggctaccata tttagtaagg
     2221 ttgttttgcc acaaccacta tttccgataa gagcatagac tttacctgca tcaaaattta
     2281 agttcaaatc actaaatacc gtccggtccc caaaggtttt tgttagttga tggattttaa
     2341 tcatttctat gctcctttca atataatact agccatccta tcttccttac gagaacgatg
     2401 cattagtatt aaaatagaat tcaaaccaaa gacgcaagag gttagaaaga ctacccaaag
     2461 tttatttgtt agcaaaagac caatagcccc tcccaaaatg aagataacta tttgccagat
     2521 aaaaaatttc tggtgtaact caaaaaaatt taatcctgat attttcttaa taagaatagt
     2581 tttacgaaat tcttcaaagt agaggattgt cattgtatta aagagtagaa ttgaggtagc
     2641 aataccgaga aaaccaccag caatgattgt caatatttca acttgaatgt tgtgactcat
     2701 accacgataa acataatagg caagatcata ctgactgata tatctcttta ttccaccttg
     2761 ttcaactagt tttttagtgg catccaaacc tttaaaatac agataatcag atggataagt
     2821 gaagaaagca ttttgatttt ttccaaaaga gcttggttta aggacaataa gtataggatc
     2881 acttagaaat tgttgatatg agattggtgt agaattatat acgaaacgct tcttattgtt
     2941 tgaaatatag aaaacacgag ctttcatagc ctgttgaatt ttattttcct tatcgtttcg
     3001 aatcgctagg aaatcttcat aaatttgacg caatttatct tcttgatctt ttaatttttc
     3061 aggcaatagt agtccaaatt ctccttctcc aaggctatta atgctcttct tatcttcttc
     3121 atttaattct acattctgaa catctaaata attaggagtc acatataagc tattagcata
     3181 cggattgtag tcatttatcg acattttttc tccgttaagg gatgtgaaga cagacctttt
     3241 agatcgaatg atgcaaaatg gatgctgaac aagcattcct ccattctgaa tgccagtttc
     3301 tatgaagttt ttccattgtt cttccaacat ttttctacta tcctgatttc taatctctga
     3361 cccaaactcc ctatttgttg aaagcaatac ccaatctttt tgatttgacc atgctgtatc
     3421 tccagactga tgcaattgcc aaatagttga atagatactt gttctatgaa tggtaagtac
     3481 tattaaaaga aaagcgacca attgccccaa gtaaagaata cccataatct gtttcaaagg
     3541 taactttcct ttgagtaaag aaaccaaatg taccgcttta atacttaaaa cataaagaaa
     3601 gctaaagagt atagaaagga acaaaagtaa caaattataa gttatgctag ctgaaaaaat
     3661 aactggaata gaaaaatggt gtgatatgga atagacttac accacagatt ccaagaaaaa
     3721 tccctgtaat tacccctaaa agtaaatctc cacaatcact aatcattgag tttccaaaaa
     3781 tctgagttag gtgcaatcca gaaatatatc gaatcccaac tgttcgcatt tccttggttt
     3841 tttgaataat cattaaggct ataaaagtta gtagaaaaaa tgaccaaaat gagtaattga
     3901 gtaccatttc ccataaacgt aaataagcta agaaaaatat ttggatatga aacaaatgtt
     3961 tctgtgaaac ccaatgattg aagttcatga tttaatctat ctagagtgag atttccagat
     4021 aaaatataat aattgacaaa taagctacta ttgtaaaaat cttctttact agctttaaca
     4081 aggccatttg ggatatggcc agatccatat attgcatagg aaaaatgaac cttaccttta
     4141 tcatctattt tttcaatttg ttgaccaatc acactgtctg tttcatttgc taattgatct
     4201 aaactgtatt ttacctgatc ttttgatacc tctttgttct gggaaagaat accaatagct
     4261 ggaaaactat tgtgaataac cagatttgag gttgaaaaac aaatccaaag tagaaaactt
     4321 gttataaaga tatttgaaag gataacaaag aagcgcttca tactttactc actttctaaa
     4381 actttcatgg atagtaatat aatcttttct atgagctatg aattttttta aaatccgtaa
     4441 ttaaaatatg ctacttcacc caaatttgta tttataaaag cttttgaggt ctgatgagca
     4501 ggagcggtac catattttga tttactatct cttgcacgag ttacgcttga ccagtgatat
     4561 tggtaatcat ggtaataatt tgaaaatgca ccccagttat ttggatcgtg attagcacca
     4621 taactccata caccaccaga aacccaatct gcaaaaaccg gacaaattaa acaacaacta
     4681 ataacaatag ttaaagaagt taaaaatatc ttataaaatt tcattattaa atacctccta
     4741 aacctatatt tataatttaa taacttattt gttttagatt acttaatctg ggacctcctt
     4801 tcatattact atccatgaaa ttctcaacaa tttatacata agggctatca aaaatattta
     4861 tgataaaatt agatattatc ttacaattct aatctcattt ctattaatga aatccccacc
     4921 atctccaaat gtctaacaag ttaaagagtg ggagtgatgc tacaaaaaat aaataaatag
     4981 tgattttttt catgtttttc acctctttct ttatatatat gatatactaa acacatatcg
     5041 aaatgtaaaa atgtcacata tatacacata attagaggtg gagtttttat gcgttgggat
     5101 tacggtacga tctataaaaa aatacggaaa tcaaaacata ttagtcaaga ggaagtttgc
     5161 cagggttaca tttcaagagc gcatttatca cgtattgaat cgaaccaagt ggtaccgagt
     5221 tttgagtcga tggagcatct tctaaagcaa gttggcttag atttcgaaga atttcgatat
     5281 atatgccatt cttaccacca ctccgatagg gaagaaatta tcttattagc ggaagataac
     5341 aatgcctacc aatcaaatga taaattattg gaactgaaga ataagagtgt agcttattta
     5401 aaaaaacatc ctaatgatat tcctgtgtta aatatactaa agagagtaga ggtcattctt
     5461 tgtttacgag aatctggtcc aaatgaaaag gtaagaatga tggcaacgga agcttggaac
     5521 gaaatcaaaa atcaggatgt ctggtatcat agtgacctaa aattaattgt cgttatttta
     5581 tttacacttc cactagaaac agtgatttct atctgtgatg aagtgataga taggctcaat
     5641 gattactctg attatacaga gattcttccc accaagtata aattactctc aaatttagct
     5701 agcatttttc tgtggaatgg tttgatggag aagtgtacga gtatcagtta tctattgtta
     5761 gatacggcca aaaaaagtaa gcgatatgat tttctaggaa atgctaaagt gacacttgga
     5821 atttgtttaa gtgataaaaa gctagttgat gaaggcttgc agttactcga attaactgat
     5881 gaaataacgt tgttggaagc atgtaggtca gatgtgaatc gttttttcaa ggaatgagtt
     5941 tctaattaag aatcgtagaa aaaggcaaag tttcttcgat ggataacgat gaatgttttg
     6001 ccatcttaaa aagctagagt ttgaattgaa atacagtaca atagttcgca tttggcaaaa
     6061 agaaaaaagc ctttgaaatc aacgtttcaa tggcttttag cttaataaat ttttttcttc
     6121 tgtaattatc aagtattaca acctatattt cttttaatat tttatcaaat aatttttcta
     6181 atttccataa ttctccatag acagttccgt ccatataaag gttgtaaatt tcatcatctt
     6241 gttccactcg tatttgtgca gaataccctt ttgatagtgc taaggaacga ataacttccc
     6301 gttgagttcg tccattacct tctcgaaagg gatggaaata attaagatta tcaagaattt
     6361 ttgctaaatg tttaatgatt tcatctcttg agttggcagt ttgatgatag gaatgaatga
     6421 gatgatttat ataagtttcc gcagcattaa acgactgtat cgacataaaa ggattaccac
     6481 ttttagagat attcaccttg cgatattgtc ctgaccaagc ataaacatct tgaaacaaat
     6541 agttatgaat ggctaaaata ttactcatgg aatagacttt aatggctttc aagcgcaaat
     6601 ctgcaagtct tttagtaacg aataagtgtt catttcggta ggcttcttca atatttgtaa
     6661 cattttgttt attgattaag actgtggaat ttggataggt atattggtga ttggggtcaa
     6721 tatactcata gccttcgtat tgatttttaa ccaatattca attcctttcg tttgttgata
     6781 acataagttt ttaaatcaat cacatcttga acagtaggtt cataattttc aatcattgat
     6841 gacccaatag cataccagac ggtatcgaaa tctgaaaagt tatcaaaggg aatccctaaa
     6901 attgttaatt cttctttatt tacatcaaga gtcatggcac acttccttgt ataacgttat
     6961 ctttattata ccataaaatc ggtattttta cctaaaagga tagagaccaa aagatatatg
     7021 taagcgtata gattaatact tacagaacta aaaatattcc cctgttttta gtccaactga
     7081 aacccatact ttccaaacca ggtcttaaga aaaaaggtag agaaaaaggt agagtttgaa
     7141 ttgaaataca gtgcaatata tcgcatttgg caaaaagaaa aaacgcttga aatcagcgtt
     7201 tttcttctgt attgattcgt attgaacccc tacttcactt ctgtaaaagt taacttatat
     7261 gcttacaaag cttattttaa cagcctttac gactgtttat gaagaaaagg tagagaaaaa
     7321 ggtagagttt caaatgactg ttaattttca ccttttattt gtgaaagtcg ttccattaaa
     7381 atatcgactg cttcattctt tcggttagga tctaattccg catagatatc cattgtggtt
     7441 gaaatagatt tgtgacccat acgttcttgt aattctttcc aatttgctcc agagttgagc
     7501 attaaagatg catgagtatg gcggaataag tgaaaaccat aatcaggtaa acctaactct
     7561 tttaatcgtt taataagagt agctcgctca tttcgatcag tcatgtaatt tccatagata
     7621 gtgggaaata tcaacttaga ttttggaagc ccatgttttt cgaagtaatt attcatttca
     7681 ttgttaaaat ctttaagttc ttgaataatg gtaataggta ctgatacttt gcgatttcct
     7741 gaatcagttt tcgcagaatt tttacaaata accttacctt tagtacctaa ggttttatct
     7801 cctctcctcc acataagagt tttatttacg ttaatttctg atgattcgaa aagtaagtca
     7861 tcaacttcca atgctaatag ttcattaatt cgtaaggcag aagctaaaag agtattacaa
     7921 ataagtttaa agcgcctgtt ggctcttgag tttgggagcg tatctaagta attcaaccat
     7981 atagcgatat ctttttcatg tagaacttga attcgatttt gaggtgcttt aggcttgggt
     8041 ggtatcctga cttgttttgc gggattattc tttagattaa agtgtaccat tccgaaatca
     8101 agaatatctt ttagtttatg aacgactgca ccataatcag atgcctttcc tttatctgcc
     8161 ttacgttttc ccttatttat ttctattcga gctttttctg ctagctgatc aacccatttt
     8221 tgaacttcag tagattcaat agaatctatt ttataatcac caaattttgg aaggatatat
     8281 gtatccaaat atccccttac tctatttcta gtattatcag atgataccca agatttataa
     8341 ctatcatacc aaaattccga cagttctttt atagtaccga cagatagagt ttcttttcga
     8401 gtagaatcat tttcttcaaa ttttctttta gtctctaaat atttgcgatc taaggctttt
     8461 agtgttggag ctgatatagt agttgtaact tgttttcctg tttttttatc agttcctaaa
     8521 taagctcctt tcatagaata agttatagaa ccatcttttt tgattttctt aagaactttc
     8581 ttattgtttc tttctattgt ctcaatttgc atttagttta cctcagatgg tcaagaattt
     8641 aagaatatcc ccacgtttat aatacactgt tcgggtccct tcgattggtg gctccaaccg
     8701 tggcagtcct ttacgttccc aacttttgag tgtattaggg gaaatattca gttctttgag
     8761 gacttccttt tgggtcataa tttctaactg attagtatct gatcttttat ccagaagatt
     8821 taccagaacc tgtaatagat tttcgatttt atctagtttt acttgttgta gtgtatccat
     8881 ataattatcc tttctaatgt ccaataacat aggtaaattg tttggcagtt tctgcgtcaa
     8941 aagtacggta actaatgatt cctaaccctt ttacattaca ttctgagacg agaattgaac
     9001 catctgattt gacctgttcc acaaatgaaa tgtgtccgta tattggatca gctccagctt
     9061 gtccagggct aaatgataga gcagagtgct ctgttggtgt atgggttgtt gtgaatcctg
     9121 gcttattcat ccattgtcca ccatttccca taaatggatc aaagttgact ccgacttgtt
     9181 ttccacggtt gaagacatac caggtacatt gtccccaagg atagtactag tgatatatcc
     9241 tgtggtatca atagctgttg tcaaactata acctaccggt atatcatttg aagtgactcc
     9301 tccaccatct ctagtttttc ctgtagtttg ttcaggagct tttggtgttc ctccatgttc
     9361 atcaatgaag gcatccagtt tttgcatggt ttcagcacgt ctttttcccg atcctgtagt
     9421 atctgtgaaa tagaccccgc catcagttgc tggattgagt gttccattcg caaacttttt
     9481 agccttatca tcttgaattt tgaaggtttg gtttttattt ccaatgatgg tttgttgggt
     9541 taattcgaca acagcaatct catcattaaa gttattggca tattctggat tggagtcata
     9601 agctccaaaa ccaaacatat tggctccagg attggtggcc accccagcag ttccaaggga
     9661 actttcattt agtgcgatcg caacgattcc acggacatca agattagatt tagcttccca
     9721 ttcg
//
