LOCUS       c00002_NZ_UHFA..       10309 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  NZ_UHFA01000002.1 Streptococcus downei MFe28 strain NCTC 11391,
            whole genome shotgun sequence.
ACCESSION   NZ_UHFA01000002
VERSION     NZ_UHFA01000002
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 6.1.1
            Run date     :: 2024-03-14 16:14:09
            Original ID  :: NZ_UHFA01000002.1
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 1910911
            Orig. end    :: 1921220
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..10309
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[1915911:1916220](-)"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193)"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(5001..5309)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193)"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
     cand_cluster    1..10309
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193)"
                     /kind="single"
                     /product="RiPP-like"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..10309
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="RiPP-like"
                     /region_number="9"
                     /rules="(strepbact or Antimicrobial14 or Bacteriocin_IId or
                     BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or
                     Lactococcin or Antimicrobial17 or Lactococcin_972 or
                     Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or
                     TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or
                     TIGR03975 or DUF692 or TIGR01193)"
                     /tool="antismash"
     CDS             complement(20..244)
                     /locus_tag="ctg2_1757"
                     /transl_table=11
                     /translation="MPSKKKTFEENLQDLEAIVTRLENGDVPLEEAISEFQKGMVLSKN
                     LQKTLEDAEKTLVKVMQADGSEAEMETND"
     aSDomain        complement(59..226)
                     /aSDomain="TIGR01280"
                     /aSTool="tigrfam"
                     /description="xseB: exodeoxyribonuclease VII, small
                     subunit"
                     /detection="hmmscan"
                     /domain_id="TIGRFam_ctg2_1757_0056"
                     /evalue="3.50E-22"
                     /identifier="TIGR01280"
                     /label="ctg2_1757"
                     /locus_tag="ctg2_1757"
                     /protein_end="62"
                     /protein_start="6"
                     /score="76.2"
                     /tool="antismash"
                     /translation="TFEENLQDLEAIVTRLENGDVPLEEAISEFQKGMVLSKNLQKTLE
                     DAEKTLVKVMQ"
     PFAM_domain     complement(74..223)
                     /aSDomain="Exonuc_VII_S"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF02609.18"
                     /description="Exonuclease VII small subunit"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg2_1757_0204"
                     /evalue="1.30E-18"
                     /label="ctg2_1757"
                     /locus_tag="ctg2_1757"
                     /protein_end="57"
                     /protein_start="7"
                     /score="66.8"
                     /tool="antismash"
                     /translation="FEENLQDLEAIVTRLENGDVPLEEAISEFQKGMVLSKNLQKTLED
                     AEKTL"
     CDS             complement(219..1562)
                     /locus_tag="ctg2_1758"
                     /transl_table=11
                     /translation="LSDYLSVSSLTKYLKLKFDRDPYLERVYLTGQVSNFRKRPNHQYF
                     SLKDEKAVIQATIWAGVFRKLGFELEEGMKINVVGRVQLYEPNGSYSIIIERAEPDGIG
                     ALAVQFEQLKKKLTQAGYFAAEHKQALPQFVKKIGVVTSSSGAVIRDIITTVSRRFPGV
                     EILLFPTKVQGEGSAQAVAENIAQANQREDLDLLIIGRGGGSIEDLWAFNEEVVVQAIF
                     ESRLPVISSVGHETDTTLADYVADRRAATPTAAAELATPVTKADILAWLREAGQRAYQA
                     TNRRIGQEGERLAKWSQSVIFRQPERLYDGHAQKLDRLTDDLSKQMRYRLSQAQQDQGL
                     LSQRLASIDLQGRLQLVKERLSQQERLLKANMANQYDSRLARFEKAQDALLSLDTSRIV
                     ARGYAIVQKDKKPITSVTDLKQGDQLTLQMKDGQVEVEVENAKQEKNI"
     PFAM_domain     complement(255..1199)
                     /aSDomain="Exonuc_VII_L"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF02601.17"
                     /description="Exonuclease VII, large subunit"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg2_1758_0206"
                     /evalue="1.60E-96"
                     /label="ctg2_1758"
                     /locus_tag="ctg2_1758"
                     /protein_end="436"
                     /protein_start="121"
                     /score="323.5"
                     /tool="antismash"
                     /translation="YFAAEHKQALPQFVKKIGVVTSSSGAVIRDIITTVSRRFPGVEIL
                     LFPTKVQGEGSAQAVAENIAQANQREDLDLLIIGRGGGSIEDLWAFNEEVVVQAIFESR
                     LPVISSVGHETDTTLADYVADRRAATPTAAAELATPVTKADILAWLREAGQRAYQATNR
                     RIGQEGERLAKWSQSVIFRQPERLYDGHAQKLDRLTDDLSKQMRYRLSQAQQDQGLLSQ
                     RLASIDLQGRLQLVKERLSQQERLLKANMANQYDSRLARFEKAQDALLSLDTSRIVARG
                     YAIVQKDKKPITSVTDLKQGDQLTLQMKDGQVEV"
     aSDomain        complement(501..1547)
                     /aSDomain="TIGR00237"
                     /aSTool="tigrfam"
                     /description="xseA: exodeoxyribonuclease VII, large
                     subunit"
                     /detection="hmmscan"
                     /domain_id="TIGRFam_ctg2_1758_0057"
                     /evalue="1.80E-126"
                     /identifier="TIGR00237"
                     /label="ctg2_1758"
                     /locus_tag="ctg2_1758"
                     /protein_end="354"
                     /protein_start="5"
                     /score="420.4"
                     /tool="antismash"
                     /translation="SVSSLTKYLKLKFDRDPYLERVYLTGQVSNFRKRPNHQYFSLKDE
                     KAVIQATIWAGVFRKLGFELEEGMKINVVGRVQLYEPNGSYSIIIERAEPDGIGALAVQ
                     FEQLKKKLTQAGYFAAEHKQALPQFVKKIGVVTSSSGAVIRDIITTVSRRFPGVEILLF
                     PTKVQGEGSAQAVAENIAQANQREDLDLLIIGRGGGSIEDLWAFNEEVVVQAIFESRLP
                     VISSVGHETDTTLADYVADRRAATPTAAAELATPVTKADILAWLREAGQRAYQATNRRI
                     GQEGERLAKWSQSVIFRQPERLYDGHAQKLDRLTDDLSKQMRYRLSQAQQDQGLLSQRL
                     ASIDLQGRL"
     PFAM_domain     complement(1272..1550)
                     /aSDomain="tRNA_anti_2"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF13742.8"
                     /description="OB-fold nucleic acid binding domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg2_1758_0205"
                     /evalue="4.80E-24"
                     /label="ctg2_1758"
                     /locus_tag="ctg2_1758"
                     /protein_end="97"
                     /protein_start="4"
                     /score="84.5"
                     /tool="antismash"
                     /translation="LSVSSLTKYLKLKFDRDPYLERVYLTGQVSNFRKRPNHQYFSLKD
                     EKAVIQATIWAGVFRKLGFELEEGMKINVVGRVQLYEPNGSYSIIIER"
     CDS             complement(1831..2658)
                     /locus_tag="ctg2_1759"
                     /transl_table=11
                     /translation="MKEFEDDYRQAIGKSGVQGLGDPRVKKELKDRVTRLQDSLASASD
                     DQSRQEIKFLLDRAKGDYQKYVTAEKKMVAKIRYDMRLQETYAKKKKQQTTIIIASIVG
                     VLLLALFIFLHFNASHRAAQNEAAAKAAFQQKSSQASSKPDAGDTLGDAELLPKNLIGT
                     WTGTQGGATISLTFAEDGTVSVTTQLSDGSYTQNSGAITSTLPVDDTTFRVVQASGNVF
                     PGQLTTGSGYDLGYKLSDDGQTLYPIQWENQGGQDIDYSQYKYDKANAFTKSK"
     CDS             complement(3023..3235)
                     /locus_tag="ctg2_1760"
                     /transl_table=11
                     /translation="MAEFTFEIEEKLLVLSENDKGWTKELNRVSFNGAPAKYDIRSWSP
                     DHTKMGKGITLTNEEFRTLVEAFKN"
     PFAM_domain     complement(3035..3181)
                     /aSDomain="PC4"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF02229.18"
                     /description="Transcriptional Coactivator p15 (PC4)"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg2_1760_0207"
                     /evalue="5.60E-12"
                     /label="ctg2_1760"
                     /locus_tag="ctg2_1760"
                     /protein_end="67"
                     /protein_start="18"
                     /score="45.2"
                     /tool="antismash"
                     /translation="DKGWTKELNRVSFNGAPAKYDIRSWSPDHTKMGKGITLTNEEFRT
                     LVEA"
     CDS             complement(3387..4676)
                     /locus_tag="ctg2_1761"
                     /transl_table=11
                     /translation="MSTNVKKRPEVLSPAGTLEKLKVAVLYGADAVFVGGQQYGLRSRA
                     GNFSMEDMQEGINFAHEHGAKVYVAANMVTHEGNEQGAGAWFRQLRDMGLDAVIVSDPA
                     LIEICATEAPGLDIHLSTQASATNVETFKFWSNYGLTRVVLAREVNMEELAEIRRRTDV
                     EIEAFVHGAMCISYSGRCTLSNHMSHRDANRGGCSQSCRWKYDLYDMPFGQERQNLKGE
                     IPEDYSMSAVDMCMIEHIPDMIENGVDSLKIEGRMKSIHYVSTVTNCYKAAVDAYMESP
                     EKFEAIKEDLIDELWKVAQRELATGFYYQTPTENEQLFGARRKIPQYKFIAEVVSFNEK
                     TMTATIRQRNVIKEGDRVEFYGPGFRHFETNIEDLHDAKGNKIDRAPNPMELLTITVPQ
                     AVQPGDMVRACKEGLVNLYQKDGSSKTVRA"
     PFAM_domain     complement(3453..3698)
                     /aSDomain="Peptidase_U32_C"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF16325.7"
                     /description="Peptidase family U32 C-terminal domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg2_1761_0209"
                     /evalue="1.90E-21"
                     /label="ctg2_1761"
                     /locus_tag="ctg2_1761"
                     /protein_end="408"
                     /protein_start="326"
                     /score="76.2"
                     /tool="antismash"
                     /translation="QYKFIAEVVSFNEKTMTATIRQRNVIKEGDRVEFYGPGFRHFETN
                     IEDLHDAKGNKIDRAPNPMELLTITVPQAVQPGDMVR"
     PFAM_domain     complement(3741..4424)
                     /aSDomain="Peptidase_U32"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF01136.21"
                     /description="Peptidase family U32"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg2_1761_0208"
                     /evalue="4.50E-87"
                     /label="ctg2_1761"
                     /locus_tag="ctg2_1761"
                     /protein_end="312"
                     /protein_start="84"
                     /score="291.2"
                     /tool="antismash"
                     /translation="AWFRQLRDMGLDAVIVSDPALIEICATEAPGLDIHLSTQASATNV
                     ETFKFWSNYGLTRVVLAREVNMEELAEIRRRTDVEIEAFVHGAMCISYSGRCTLSNHMS
                     HRDANRGGCSQSCRWKYDLYDMPFGQERQNLKGEIPEDYSMSAVDMCMIEHIPDMIENG
                     VDSLKIEGRMKSIHYVSTVTNCYKAAVDAYMESPEKFEAIKEDLIDELWKVAQRELATG
                     FYYQTP"
     CDS             complement(5001..5309)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: Bacteriocin_IIc"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg2_1762"
                     /sec_met_domain="Bacteriocin_IIc (E-value: 2.9e-08,
                     bitscore: 30.9, seeds: 35, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNTAALDTMAFDKFEVADMDYLTSIEAGSFSWKSFNDAVGNGGLA
                     GAATGATEGAMVGAMGGTAVCPGVGTVTGAFACGVANGFIGAIVGGIGGGVNYLLNC"
     CDS             6202..7209
                     /locus_tag="ctg2_1763"
                     /transl_table=11
                     /translation="MTKKNLLKGERIDQLFSTDVKIIQNKEVFSYSVDSVLLSRFPKFP
                     AKGLIVDLCSGNGAVGLFASTKTKAKIMEVELQERLADMGQRSIELNGLSEQVTMINDD
                     LKNLMDHTPRSKVDLILCNPPYFKATKTSKKNASQHYLLARHEIATNLEEICQVSQQAL
                     KTKGRLALVHRPDRFLEILDTLKKYKLAPKRVQFVYPKADKEANMILVEAIKDGSPDGL
                     KILPPLVVHKPNGDYTDAIHDIYFGPNHKAYYMYVLKCADGSLYTGYTTDLDKRLATHN
                     AGKGAKYTKSRLPVDLLYYETFNHKNAAMSAEAKFKLKTRDEKLEYIQEHKNKE"
     PFAM_domain     6259..6723
                     /aSDomain="MTS"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF05175.16"
                     /description="Methyltransferase small domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg2_1763_0210"
                     /evalue="1.00E-11"
                     /label="ctg2_1763"
                     /locus_tag="ctg2_1763"
                     /protein_end="174"
                     /protein_start="19"
                     /score="44.8"
                     /tool="antismash"
                     /translation="VKIIQNKEVFSYSVDSVLLSRFPKFPAKGLIVDLCSGNGAVGLFA
                     STKTKAKIMEVELQERLADMGQRSIELNGLSEQVTMINDDLKNLMDHTPRSKVDLILCN
                     PPYFKATKTSKKNASQHYLLARHEIATNLEEICQVSQQALKTKGRLALVHR"
     PFAM_domain     6958..7170
                     /aSDomain="GIY-YIG"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF01541.26"
                     /description="GIY-YIG catalytic domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg2_1763_0211"
                     /evalue="2.40E-15"
                     /label="ctg2_1763"
                     /locus_tag="ctg2_1763"
                     /protein_end="323"
                     /protein_start="252"
                     /score="56.6"
                     /tool="antismash"
                     /translation="YYMYVLKCADGSLYTGYTTDLDKRLATHNAGKGAKYTKSRLPVDL
                     LYYETFNHKNAAMSAEAKFKLKTRDE"
     CDS             complement(7393..8277)
                     /gene_functions="regulatory (smcogs) SMCOG1014:LysR family
                     transcriptional regulator (Score: 114.7; E-value: 7.9e-35)"
                     /gene_kind="regulatory"
                     /locus_tag="ctg2_1764"
                     /transl_table=11
                     /translation="MNLKDFYYFQELAKLNSFTAVAQSFKVSQPTITYAVKRLEDYFNC
                     DLFIKDPSHRSVILTQQGQILAQHIEHILEEVRQSKKEIGRANQKVIKLGFPPIIRARI
                     LSQLIGRGADLSFLSAFSMVGDGSLDLLQELVVGDLDFSLLGSLRTLDHPKLVTKELYQ
                     RSFYIMVSEKHPLAKKKSLSFQEVLSESFILLDEGHTHLEAFNQLNEKYHNQAKVLLKL
                     SEVSMIGQLVRENLGLIFLTDFVLFSDIEGLVKIPLVPEDNFTFHVSYAYPKQALLADA
                     TKQLIELLEVVKE"
     PFAM_domain     complement(7411..8013)
                     /aSDomain="LysR_substrate"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF03466.22"
                     /description="LysR substrate binding domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg2_1764_0213"
                     /evalue="5.60E-23"
                     /label="ctg2_1764"
                     /locus_tag="ctg2_1764"
                     /protein_end="289"
                     /protein_start="88"
                     /score="81.5"
                     /tool="antismash"
                     /translation="QKVIKLGFPPIIRARILSQLIGRGADLSFLSAFSMVGDGSLDLLQ
                     ELVVGDLDFSLLGSLRTLDHPKLVTKELYQRSFYIMVSEKHPLAKKKSLSFQEVLSESF
                     ILLDEGHTHLEAFNQLNEKYHNQAKVLLKLSEVSMIGQLVRENLGLIFLTDFVLFSDIE
                     GLVKIPLVPEDNFTFHVSYAYPKQALLADATKQLIELL"
     PFAM_domain     complement(8086..8271)
                     /aSDomain="HTH_1"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00126.29"
                     /description="Bacterial regulatory helix-turn-helix
                     protein, lysR family"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg2_1764_0212"
                     /evalue="1.60E-13"
                     /label="ctg2_1764"
                     /locus_tag="ctg2_1764"
                     /protein_end="64"
                     /protein_start="2"
                     /score="50.5"
                     /tool="antismash"
                     /translation="LKDFYYFQELAKLNSFTAVAQSFKVSQPTITYAVKRLEDYFNCDL
                     FIKDPSHRSVILTQQGQ"
     CDS             8433..10055
                     /locus_tag="ctg2_1765"
                     /transl_table=11
                     /translation="MKAHEILNNPFINKGTAFTMEERKENGLIGLLPPYVQTIEEQADQ
                     AYQHYLQKPSDLEKRLFLMEIFNTNRTLFYYLFNQHIVEFNPIVYDPTIADTIENYSQL
                     FVDPQYAAYLDINHPENIEETLKNAAGDRDIRLIVATDAEGILGIGDWGVQGVDISVGK
                     LMVYTAAAGIDPASVMPLVIDAGTNRQELLDDPMYLGNRHQRVRGDKYYDFIDKFVQTA
                     ESLFPKLYLHWEDFGRSNAATILDKYKKDIPTFNDDIQGTGIVVLGGIFGALDITGEKL
                     TDQVYLCYGGGSAGAGIASRVHAEMVAEGLSEEEAYKHFFMIDQQGLLFDDMDDLTPAQ
                     KPFAKKRADFANADELTDLLQVIKTVKPTILVGTSTDAGAFTKEVVEAMCQNTQRPVIF
                     PISNPTKKLEATAEQVIQWSDGKAFVATGVPSGTVSYKGVDYQIGQANNALIYPGLGLG
                     MLASEAKLLTDEMIGAAAHSLSGLVDPGQAGAPVLPPFQYVAEVSIKVAEAVAKMAQEQ
                     GLAQAKETDMAKAVRDLKWYPQY"
     PFAM_domain     8634..9179
                     /aSDomain="malic"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00390.21"
                     /description="Malic enzyme, N-terminal domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg2_1765_0214"
                     /evalue="1.50E-67"
                     /label="ctg2_1765"
                     /locus_tag="ctg2_1765"
                     /protein_end="249"
                     /protein_start="67"
                     /score="227.0"
                     /tool="antismash"
                     /translation="NTNRTLFYYLFNQHIVEFNPIVYDPTIADTIENYSQLFVDPQYAA
                     YLDINHPENIEETLKNAAGDRDIRLIVATDAEGILGIGDWGVQGVDISVGKLMVYTAAA
                     GIDPASVMPLVIDAGTNRQELLDDPMYLGNRHQRVRGDKYYDFIDKFVQTAESLFPKLY
                     LHWEDFGRSNAATILDKYK"
     PFAM_domain     9207..9974
                     /aSDomain="Malic_M"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF03949.17"
                     /description="Malic enzyme, NAD binding domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg2_1765_0215"
                     /evalue="4.20E-99"
                     /label="ctg2_1765"
                     /locus_tag="ctg2_1765"
                     /protein_end="514"
                     /protein_start="258"
                     /score="331.1"
                     /tool="antismash"
                     /translation="IQGTGIVVLGGIFGALDITGEKLTDQVYLCYGGGSAGAGIASRVH
                     AEMVAEGLSEEEAYKHFFMIDQQGLLFDDMDDLTPAQKPFAKKRADFANADELTDLLQV
                     IKTVKPTILVGTSTDAGAFTKEVVEAMCQNTQRPVIFPISNPTKKLEATAEQVIQWSDG
                     KAFVATGVPSGTVSYKGVDYQIGQANNALIYPGLGLGMLASEAKLLTDEMIGAAAHSLS
                     GLVDPGQAGAPVLPPFQYVAEVSIKVAEAVAKMA"
ORIGIN
        1 agcatcaatt ttttcaagct tagtcatttg tttccatttc tgcttcacta ccatcggcct
       61 gcatgacctt aaccagggtc ttttcagcgt cctctagagt cttttgcaaa ttcttagaaa
      121 gcaccatgcc cttttgaaac tccgaaatag cctcttccaa gggcacatcg ccgttctcta
      181 atctagtgac gatggcttct aaatcctgta aattttcttc aaatgttttt ttcttgcttg
      241 gcattttcca cctctacttc tacttgacca tccttcatct gcagggtcaa ctggtccccc
      301 tgcttgaggt ccgtgacact agtaatgggc ttcttatctt tttggacaat ggcatagcct
      361 cgagccacaa tccgactggt atctagggat aagagggcat cctgagcctt ttcaaaacga
      421 gccaggcggc tatcatattg attggccata ttggccttga gcaggcgttc ctgctgagat
      481 aggcgctctt ttactagctg taaacgcccc tgcaaatcaa tactggcaag cctttggcta
      541 agcaggccct gatcttgctg ggcctggctt aagcggtaac gcatttgctt acttaaatca
      601 tctgtcaagc gatccagctt ttgcgcatga ccatcataga gtcgctccgg ttggcgaaag
      661 ataaccgatt gactccattt agccagtcgt tcaccctctt ggccaatcct gcgattggtg
      721 gcctgatagg ccctttgtcc agcctctcgc aaccaagcca gaatatcagc cttggtaaca
      781 ggcgtagcca attcagcggc tgctgttggc gtggctgccc gtctatcggc cacatagtct
      841 gccagagttg tgtccgtttc gtgaccaaca ctagaaataa caggcagacg ggattcaaaa
      901 atggcctgga ctacgacttc ctcattgaag gcccagaggt cctcaatcga accgcccccc
      961 cgaccaataa tgagaaggtc caggtcctct ctttgattag cctgggcaat attttcagct
     1021 acagcctgag cactgccctc accctgaacc ttggtgggaa agagaaggat ttccaccccc
     1081 gggaagcgtc ggctaaccgt tgtgatgatg tcgcgaataa cagccccgct agaggacgta
     1141 accacgccaa tcttttttac aaattgtggc agggcctgct tgtgctcggc cgcaaaataa
     1201 ccagcctgag tcagcttttt cttgagttgt tcaaactgga cagccagagc gccaatgcca
     1261 tctggctcag ctcgctcaat aatgatggag taggaaccat tgggctcgta gagttggaca
     1321 cgaccaacaa cattaatctt catgccctct tcaagctcaa aacctagctt gcgaaagaca
     1381 cctgcccaga tggtggcctg aatgacagcc ttctcatcct tgagggaaaa gtattggtgg
     1441 ttgggccgtt tgcggaagtt ggaaacctgt cccgtcagat aaacccgctc cagatatgga
     1501 tctcggtcaa attttaattt aagatattta gtcagagaac tgactgacaa ataatccgac
     1561 aagggctacc tcccaactct ttcaagagta aatgttagtt tatattatag caaaatttag
     1621 ctaagagagc catgaaaatg tatattatta ggcttaaaaa gggggaaact ttcaaattta
     1681 tacagggtca gccagcctta gctagaacca agaaagctgg ctgtcatttc ctcaaacagc
     1741 tttgcatttt ctgtaagctg attagctggt atccttgagc ccagcgaaat ggcgcaaaaa
     1801 agccagcctg actggctagc ctatgaaaat ttattttgat ttggtgaagg cattagcctt
     1861 gtcatactta tactggctat agtcaatatc ttgaccgcct tgattctccc attggatagg
     1921 gtagagggtc tgaccatcat cactcaactt atagcctaag tcataacctg agcccgttgt
     1981 caattgacct ggaaaaacat ttcccgatgc ttggacaacc ctaaaggtcg tgtcatcaac
     2041 ggggagggtt gaggtaatag caccagagtt ttgcgtgtag ctaccatcgc tgagttgagt
     2101 cgtcacgctg accgttccat cctcagcaaa ggtcaaacta atggtcgccc caccctgtgt
     2161 tcccgtccaa gtgccgatga gatttttggg aagcaattca gcatctccca aggtatctcc
     2221 ggcatctggc ttggaggaag cttggctgga cttttgctgg aaggcggcct tggctgctgc
     2281 ctcgttctga gcagcacggt gggaggcatt aaaatgcaaa aagataaaga gtgccaacaa
     2341 aagaacacct acaatagaag caatgatgat ggtcgtctgt tgcttcttct ttttggcata
     2401 ggtttcctgc aagcgcatat cgtaacgaat ctttgctacc atcttcttct cagccgtcac
     2461 atacttctga taatcgccct tggctctatc cagaagaaac ttaatctcct gacgggactg
     2521 gtcatcgcta gcagaggcta gagaatcttg cagacgggtg acgcgatctt tcaattcctt
     2581 tttaactcta gggtctccca gaccctggac accgctttta ccgattgcct gcctgtaatc
     2641 atcctcaaat tctttcattg gccacctgtt cctttttcct tggcttactt ttaatattgt
     2701 aacctctttc agaaaacttt gtcaagataa tactgttaaa gacaggggca aggacaaagg
     2761 tccttaacct tttactttct taccaccaaa cattttgagg tggtgctgat tggaaaatct
     2821 tgtagctgtg agaggatttt gactttttag aggctgggca aatggagtca caaaaaaagg
     2881 cgaccactgc tttttgggca gggcctcctc agatgatctt atactcttca aaaatcaaaa
     2941 ctatccatcg ttaactcact ttgccgtacc caagtactgc ctgcagttcg ttgccttggc
     3001 tatttttgat ttttattgag cattagtttt taaaggcttc aactagggtc ctaaactcct
     3061 cattggtcaa ggtaatgccc ttgcccatct tagtgtggtc ggggctccaa gaacgaatat
     3121 cgtacttggc tggggcccca ttgaagctca cccgattgag ttccttggtc cagcccttgt
     3181 cattttccga gagtaccaag agcttttctt caatttcaaa tgtaaattct gccataggtt
     3241 tatcctttca ataagccaga taatcgagcg ttatcggttc gcttatctga ctgtcgctaa
     3301 cttttaaata aagccgccta gctggactta tctaacacct gcagacggct tcacttatct
     3361 attcgtaatt gctcagaaaa cctagctcaa gctcgaacgg ttttactaga gccgtccttt
     3421 tgatagaggt taaccagtcc ctccttacag gcccgaacca tgtcacctgg ttgaacagcc
     3481 tggggaactg tgatggtcaa gagttccata ggatttgggg cgcggtcaat tttattgcct
     3541 ttggcatcat gtaggtcttc gatgttggtt tcaaaatgac ggaagcctgg accgtagaac
     3601 tcaacccggt caccttcctt gataacatta cgctggcgaa tggtggccgt catggtcttc
     3661 tcattaaaag agacaacctc tgcgataaat ttatattgag gaatcttgcg acgggcccca
     3721 aagagttgct cgttttcagt tggcgtttgg taatagaagc cagtagccaa ttcgcgttgg
     3781 gccaccttcc agagttcgtc aatcaagtcc tccttgatag cctcaaattt ttctggactt
     3841 tccatatagg catccaccgc tgccttatag cagttggtta cggttgagac gtagtggata
     3901 gacttcatcc gaccttcgat tttcaggcta tccacaccat tttcaatcat atctggaata
     3961 tgctcaatca tgcacatatc aacggctgac atggagtagt cctcgggaat ttctccctta
     4021 agattttgcc gctcttggcc aaaaggcata tcatagaggt catacttcca gcgacaggat
     4081 tgggaacaac cgcccctatt ggcatcgcgg tggctcatgt gattggacag ggtacagcga
     4141 cctgaataag aaatacacat agccccgtgg acgaaggctt caatttcgac atcggtccga
     4201 cggcgaatct ctgccagctc ttccatgtta acctcacgag ctagaacaac ccgagtcagg
     4261 ccatagttgc tccagaattt gaaggtttca acattggtag ctgaggcttg agtggacagg
     4321 tgaatgtcca gacctggtgc ctcggtcgca cagatctcaa tcagggctgg gtcagagacg
     4381 atgaccgcat ccagtcccat gtctcgcaat tggcggaacc aagcgccagc tccctgctca
     4441 ttgccttcgt gggtgaccat attggccgct acatagacct tagccccatg ctcatgggca
     4501 aagttaatcc cttcttgcat atcttccatg ctaaagttac cagctcgact acgtaggcca
     4561 tactgttggc caccaacaaa gacagcatcg gccccgtaga gaacggcaac ctttaatttt
     4621 tccaaggtcc cagccggtga gagcacctca ggacgtttct tgacatttgt tgacatatct
     4681 atctcctctg cgattgaaaa aatcaatcgc caagtttctt ttttagctct tccattctaa
     4741 agcaaatccc cctaaaaatc aaggaaagga gctggtccaa acgacagagc aattggcctg
     4801 atcagacaaa aagaacctag ctgagactag attcctagta ctttatcatt agtttcttgt
     4861 gcagatagct agctaccctg aggtaaccaa agataatctt cacaacaagt tattttggtt
     4921 ttttccgatt gaccaactgt ataattatta tgacaactag cgctgtgata gctcccgtaa
     4981 tgtaatattt catattaacc tcagcaattc agtaaatagt tcacgcctcc gccaattcca
     5041 ccaacgattg caccaataaa tccatttgca acaccacaag caaatgcacc tgttacagtt
     5101 cctacaccag gacaaacggc agtccctccc attgctccta ccatagctcc ttcggtagca
     5161 ccggtagcag ctccggcaag tcctccatta cctacggcat cgttgaagct cttccaacta
     5221 aaacttccag cttcaataga tgtcaaataa tccatatccg ctacttcaaa cttatcaaaa
     5281 gccatggtat ccaatgctgc tgtattcata aaattctctt tattctaagt caccagagtt
     5341 tcagcaagtc tctctagcaa cgaaatcttt tacgtccctc atcctatcac ttaatttttt
     5401 ctcaatcaag accttctcgg aagctttaat tagaacgtta atattccata aaaaaacata
     5461 aattttctga caattaatgc taaagatggg gggccttagc tactaaacaa attacaagac
     5521 aataacaaaa aagcaagggt tgaattatag tttcgtcttt gatttttaca ctattagttc
     5581 cctttgggac taggcaaaat tggccaatag aacttgttct ccccatccat cctaacactc
     5641 gtcagatagg aacaactttt ttatccttta gtcatcatga agctgatagt agtaaatatg
     5701 gtccatagcc cccttcgtct aagaccagaa caagtcaggg catagagggc tagaagtatt
     5761 atcaataaga atagggagac cgaaaatagg gcctttaatt tctcattttt ggaacgccta
     5821 ttgaaaatgg tcgttaaaat gaccaaaagt agccaaagaa taaaaagatt gtacttcatg
     5881 ataggtttct gcctttctat aaatgcctac tgagccaatc aggccgggct cttcacctgc
     5941 tttacttttt cttctgattc aagatctggt tgcctgcccc ctagaaccat gatggtccat
     6001 aatcctccga taatggccta tgacctcttc tcctcccaca gctggctagg tgaaaattta
     6061 ctggatcgtt ttttattggc aagaagattg gtcaaattta tgatgccagc tcttaggctg
     6121 aacattcctg cttctctgtc tgctagtccc gacaaactac agccctaggc ctagcgggca
     6181 aagcgtgcta taataattcc catgactaag aaaaatctgc tcaaggggga gcgtattgac
     6241 cagctcttct caactgatgt aaaaattatt caaaacaagg aagtttttag ctactcagtg
     6301 gattcggttc tgctttctcg ttttcccaaa tttcctgcca agggactgat tgttgacctc
     6361 tgctctggca acggggcggt tggcctcttt gcttccacca aaaccaaggc caagattatg
     6421 gaggtggaac tgcaggaaag gctggcagat atgggccagc gctccattga gctcaatgga
     6481 ctttctgagc aagtgaccat gattaacgat gacctaaaaa atctcatgga ccacacccct
     6541 cgctcaaagg tggacctgat tctctgcaat ccgccctatt ttaaggcgac aaagacctct
     6601 aagaaaaatg ccagccagca ctacctcttg gctcgccatg aaattgccac caaccttgaa
     6661 gaaatttgtc aggtcagcca acaggccctg aaaaccaagg gacgcttagc tctcgtccac
     6721 agacccgacc gctttttaga aatcctggac accctgaaaa aatataagtt ggcacctaag
     6781 cgggttcagt ttgtctatcc caaggccgat aaggaagcca atatgattct ggttgaagcc
     6841 attaaggatg gctcgcctga cgggctcaag attttgccac cgctggttgt tcacaagcct
     6901 aatggtgact acaccgatgc cattcatgac atctattttg gtcccaacca caaggcctat
     6961 tatatgtatg ttctcaagtg tgccgatggt agcctctata ccggttatac gaccgatttg
     7021 gacaaacgtc tggccaccca caatgccggt aagggagcca aatacaccaa gtcacgcttg
     7081 ccagtcgact tgctctatta cgagaccttc aaccacaaga acgccgccat gtcggctgaa
     7141 gccaaattca aactcaagac tcgagacgaa aaattagaat acattcaaga acataagaat
     7201 aaggagtagg ctaggtgcct gctccttgtt ttattttcaa tttttttgtt ctatcaaagc
     7261 aaaagaaaaa acagaccata gtttttctct aatttatctt cgacctagga tggaaagttt
     7321 tttacttatt aagccatttt ttctaatcta gagtcgattt aataagtttt ttcataacaa
     7381 atcctgtcct tttcactcct taaccacctc caggagttca atcagttgct tggtagcatc
     7441 agccagaagg gcctgtttgg gataggcata ggagacatga aaggtgaaat tatcctctgg
     7501 gacgaggggg attttgacta ggccctcaat gtcggagaag aggacaaaat cggtcaggaa
     7561 gatgaggcct aaattctcac ggactaactg gccaatcatg gagacttcac tgagtttgag
     7621 gaggaccttg gcctggttgt ggtatttttc atttagctgg ttaaaggctt caagatgggt
     7681 atggccttca tccaagagga taaaggattc gctcagaacc tcttggaagg agaggctttt
     7741 tttcttggcc agagggtgct tttccgagac cataatgtaa aaggagcgtt gatagagttc
     7801 cttggtcact agcttgggat ggtccaaagt ccgcaggcta cctagcagac tgaaatctaa
     7861 atcgccaaca accagctcct gcaagaggtc aagggatccg tctcccacca tgctaaaggc
     7921 tgataaaaag gagaggtctg cccctcggcc aatcagctgg gagagtattc tagcacggat
     7981 aataggagga aaaccaagct tgatgacctt ttgattggcc cgcccaattt ccttcttgga
     8041 ttgcctgact tcttctaaaa tatgctcaat atgttgggct aaaatttgcc cctgctgggt
     8101 taggataacc gagcgatggg agggatcctt aataaaaagg tcacaattga aatagtcttc
     8161 caacctcttg actgcatagg taatggtggg ctggctgacc ttaaaagact gggccaccgc
     8221 cgtaaaggaa ttgagtttgg ctaattcttg aaaatagtaa aaatctttta aattcatgag
     8281 ggcctccagc cttattttac cacatgcact agtccttata aataaaattt ataataattc
     8341 tcctgtttga ctataagaat ttttgggggc tataatggcg acaactcgtc gagagttacc
     8401 caattaaatt ttaatcagag gagaactgat tcatgaaagc acatgaaatt ttaaacaacc
     8461 ctttcattaa caaagggact gccttcacta tggaagaacg taaagaaaat ggcctgattg
     8521 gtctcttacc accttatgtt caaacgattg aagaacaggc tgaccaagcc taccagcact
     8581 acctgcaaaa accatcggat ttggaaaaac gccttttctt gatggaaatt ttcaatacca
     8641 accgcaccct cttctactac ctcttcaacc aacatattgt tgagttcaac ccaatcgtct
     8701 acgatccaac tatcgctgac accattgaga actacagcca acttttcgtc gatccccagt
     8761 atgccgctta tttggacatc aaccatccag aaaatattga agaaaccctg aaaaatgcgg
     8821 ctggcgaccg agatattcgc ttgattgtgg cgaccgatgc cgaagggatt ctgggtatcg
     8881 gtgactgggg tgtccaaggg gtggatatct ctgtcggtaa actgatggtc tataccgctg
     8941 ctgctggtat cgacccagca tctgtcatgc ctttagtgat tgatgccggt accaatcgcc
     9001 aagaactctt ggatgacccc atgtatctgg gtaaccgtca ccaacgggtg cgcggtgaca
     9061 agtactacga cttcatcgat aaattcgtcc aaaccgcaga aagtctcttt cctaaactct
     9121 acctgcactg ggaagacttc ggtcgctcta atgccgcaac cattcttgat aagtataaga
     9181 aagacattcc aaccttcaac gatgatatcc aaggaactgg tatcgtggtt ctcggtggta
     9241 tctttggtgc tctggacatc actggtgaaa aattaactga ccaagtctac ctctgctacg
     9301 gtggcggttc tgctggtgct ggtattgcgt cacgggttca cgccgaaatg gtagccgaag
     9361 gtctttctga agaagaagcc tacaaacact tctttatgat tgaccaacag ggtctgctct
     9421 ttgacgatat ggacgatttg acgccagctc aaaaaccatt tgccaagaag cgtgccgact
     9481 ttgctaatgc tgatgagctg accgacctgc tccaagttat caagaccgtt aaaccaacca
     9541 tcctggtcgg cacttctacc gatgctggtg ccttcaccaa ggaagtggtt gaggctatgt
     9601 gtcaaaatac gcagcgccca gttatcttcc caatctctaa cccaaccaag aaattggaag
     9661 ctacggctga gcaagtgatt caatggtctg acggtaaggc ttttgtcgca acaggtgtgc
     9721 cttctggaac ggtttcctac aagggtgttg actatcaaat tggtcaagcc aacaatgcgc
     9781 tcatctaccc aggccttggg cttggtatgt tggcatctga agccaagctc ctgaccgatg
     9841 aaatgatcgg ggcagcagct cattccctca gtggtctggt tgacccaggc caagcagggg
     9901 ctcctgtgct tccaccattc caatacgtgg ctgaagtttc tatcaaggtg gccgaagctg
     9961 tcgctaagat ggctcaagaa caaggactag cacaggctaa agaaaccgat atggccaagg
    10021 ccgtgcgtga cctcaagtgg tatcctcaat actaagctgg aggttgcgac ccattatgaa
    10081 aaaacttaat gagattaaaa tttcaggtat cagtctaccc ctctacgctg gtttagtcct
    10141 aatcctggct atcgccatcg ctcttggtaa gttgccccta aatatgctgg gcatcacctt
    10201 tatgctagtg ctgctaggtc acctctttta ttggattggc caaaaaacac caatcttcaa
    10261 cacctatctc ggtggcggat cagtcatgac cctgcttcta gcagccctg
//
