LOCUS       c00002_NZ_UHFA..        7433 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  NZ_UHFA01000002.1 Streptococcus downei MFe28 strain NCTC 11391,
            whole genome shotgun sequence.
ACCESSION   NZ_UHFA01000002
VERSION     NZ_UHFA01000002
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 6.1.1
            Run date     :: 2024-03-14 16:14:09
            Original ID  :: NZ_UHFA01000002.1
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 338509
            Orig. end    :: 345942
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     CDS             complement(1..354)
                     /locus_tag="ctg2_300"
                     /transl_table=11
                     /translation="MTDLNQAVKKLQTLMAQHESVEAFQAVQAKVKAQPNLNHLAHDMK
                     TYQQEAVLYEKLEKNRAADQSGQAADRLNQELSNLPLVQDYRSKMQDASDLLQYVTKSL
                     EEKINEGLANGKR"
     protocluster    1..7433
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[341853:342081](-)"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193)"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(3345..3572)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193)"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
     cand_cluster    1..7433
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193)"
                     /kind="single"
                     /product="RiPP-like"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..7433
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="RiPP-like"
                     /region_number="6"
                     /rules="(strepbact or Antimicrobial14 or Bacteriocin_IId or
                     BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or
                     Lactococcin or Antimicrobial17 or Lactococcin_972 or
                     Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or
                     TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or
                     TIGR03975 or DUF692 or TIGR01193)"
                     /tool="antismash"
     PFAM_domain     complement(28..339)
                     /aSDomain="Com_YlbF"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF06133.13"
                     /description="Control of competence regulator ComK,
                     YlbF/YmcA"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg2_300_0130"
                     /evalue="2.20E-12"
                     /label="ctg2_300"
                     /locus_tag="ctg2_300"
                     /protein_end="109"
                     /protein_start="5"
                     /score="47.5"
                     /tool="antismash"
                     /translation="QAVKKLQTLMAQHESVEAFQAVQAKVKAQPNLNHLAHDMKTYQQE
                     AVLYEKLEKNRAADQSGQAADRLNQELSNLPLVQDYRSKMQDASDLLQYVTKSLEEKIN
                     "
     CDS             complement(354..782)
                     /locus_tag="ctg2_301"
                     /transl_table=11
                     /translation="MNKIERQNKIRAIIQEERVGTQEEIKASLARQGIAVTQATLSRDL
                     REIGLLKRRDENGKLYYSLSAEETSHLSDVARDYIKKISRASFILVLSTELGEADVLAN
                     IIDREGRSDILGTVAGADTLLVICQDAVKAQTIEEELN"
     PFAM_domain     complement(360..554)
                     /aSDomain="Arg_repressor_C"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF02863.20"
                     /description="Arginine repressor, C-terminal domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg2_301_0132"
                     /evalue="6.50E-17"
                     /label="ctg2_301"
                     /locus_tag="ctg2_301"
                     /protein_end="141"
                     /protein_start="76"
                     /score="61.2"
                     /tool="antismash"
                     /translation="RDYIKKISRASFILVLSTELGEADVLANIIDREGRSDILGTVAGA
                     DTLLVICQDAVKAQTIEEEL"
     aSDomain        complement(360..770)
                     /aSDomain="TIGR01529"
                     /aSTool="tigrfam"
                     /description="argR_whole: arginine repressor"
                     /detection="hmmscan"
                     /domain_id="TIGRFam_ctg2_301_0032"
                     /evalue="2.30E-48"
                     /identifier="TIGR01529"
                     /label="ctg2_301"
                     /locus_tag="ctg2_301"
                     /protein_end="141"
                     /protein_start="4"
                     /score="161.9"
                     /tool="antismash"
                     /translation="ERQNKIRAIIQEERVGTQEEIKASLARQGIAVTQATLSRDLREIG
                     LLKRRDENGKLYYSLSAEETSHLSDVARDYIKKISRASFILVLSTELGEADVLANIIDR
                     EGRSDILGTVAGADTLLVICQDAVKAQTIEEEL"
     PFAM_domain     complement(579..782)
                     /aSDomain="Arg_repressor"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF01316.23"
                     /description="Arginine repressor, DNA binding domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg2_301_0131"
                     /evalue="5.70E-25"
                     /label="ctg2_301"
                     /locus_tag="ctg2_301"
                     /protein_end="68"
                     /protein_start="0"
                     /score="87.0"
                     /tool="antismash"
                     /translation="MNKIERQNKIRAIIQEERVGTQEEIKASLARQGIAVTQATLSRDL
                     REIGLLKRRDENGKLYYSLSAEE"
     CDS             938..2629
                     /locus_tag="ctg2_302"
                     /transl_table=11
                     /translation="MDSKLIIAQEIQAALPDMELEAIVNLLEVPKNSSMGDLAFPVFSL
                     AKVLRKAPQAIASELVEKIQSDKFEKVQAVGPYINFFLNKQEISQAVLAEVIAKDKDYG
                     QQELGQCKNITIDMSSPNIAKPFSVGHLRSTVIGDSLAKIFEKIGYKSVKINHLGDWGK
                     QFGMLIVAYKKWGDEGAVRATPINELLKLYVRINKEAESQPELDEEARDWFRKLEAGDQ
                     EAISLWQWFRDESLVEFNRLYDLLRVQFDSYNGEAFYNDKMDEVVTLLEDKDLLQESQG
                     AQVVKLDKYGIENPALIKKSDGATLYITRDLAAALYRKRTYDFAKSIYVVGNEQAAHFK
                     QLKAVLKEMDYDWSDDITHVPFGLVTKDGKKLSTRKGNVILLEPTIAEAIKRAGDQIEA
                     KNPDLPNKEAVAQAVGVGAIKFYDLKTDRLNGYDFDLDAMVSFEGETGPYVQYAYARIQ
                     SILRKADFKADPAVGYYLDDAESWEIIKLIQNFPAAIKRAADNFEPSIIAKFAISLAQA
                     FNKYYAHNRILDQSPERDSRLALSYTTALVLKEALRLLGVDAPDEM"
     PFAM_domain     956..1186
                     /aSDomain="Arg_tRNA_synt_N"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF03485.18"
                     /description="Arginyl tRNA synthetase N terminal domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg2_302_0133"
                     /evalue="3.20E-18"
                     /label="ctg2_302"
                     /locus_tag="ctg2_302"
                     /protein_end="83"
                     /protein_start="6"
                     /score="66.2"
                     /tool="antismash"
                     /translation="IAQEIQAALPDMELEAIVNLLEVPKNSSMGDLAFPVFSLAKVLRK
                     APQAIASELVEKIQSDKFEKVQAVGPYINFFL"
     aSDomain        959..2626
                     /aSDomain="TIGR00456"
                     /aSTool="tigrfam"
                     /description="argS: arginine--tRNA ligase"
                     /detection="hmmscan"
                     /domain_id="TIGRFam_ctg2_302_0033"
                     /evalue="3.70E-160"
                     /identifier="TIGR00456"
                     /label="ctg2_302"
                     /locus_tag="ctg2_302"
                     /protein_end="563"
                     /protein_start="7"
                     /score="532.0"
                     /tool="antismash"
                     /translation="AQEIQAALPDMELEAIVNLLEVPKNSSMGDLAFPVFSLAKVLRKA
                     PQAIASELVEKIQSDKFEKVQAVGPYINFFLNKQEISQAVLAEVIAKDKDYGQQELGQC
                     KNITIDMSSPNIAKPFSVGHLRSTVIGDSLAKIFEKIGYKSVKINHLGDWGKQFGMLIV
                     AYKKWGDEGAVRATPINELLKLYVRINKEAESQPELDEEARDWFRKLEAGDQEAISLWQ
                     WFRDESLVEFNRLYDLLRVQFDSYNGEAFYNDKMDEVVTLLEDKDLLQESQGAQVVKLD
                     KYGIENPALIKKSDGATLYITRDLAAALYRKRTYDFAKSIYVVGNEQAAHFKQLKAVLK
                     EMDYDWSDDITHVPFGLVTKDGKKLSTRKGNVILLEPTIAEAIKRAGDQIEAKNPDLPN
                     KEAVAQAVGVGAIKFYDLKTDRLNGYDFDLDAMVSFEGETGPYVQYAYARIQSILRKAD
                     FKADPAVGYYLDDAESWEIIKLIQNFPAAIKRAADNFEPSIIAKFAISLAQAFNKYYAH
                     NRILDQSPERDSRLALSYTTALVLKEALRLLGVDAPDEM"
     PFAM_domain     1220..2242
                     /aSDomain="tRNA-synt_1d"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00750.21"
                     /description="tRNA synthetases class I (R)"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg2_302_0134"
                     /evalue="1.50E-101"
                     /label="ctg2_302"
                     /locus_tag="ctg2_302"
                     /protein_end="435"
                     /protein_start="94"
                     /score="339.9"
                     /tool="antismash"
                     /translation="EVIAKDKDYGQQELGQCKNITIDMSSPNIAKPFSVGHLRSTVIGD
                     SLAKIFEKIGYKSVKINHLGDWGKQFGMLIVAYKKWGDEGAVRATPINELLKLYVRINK
                     EAESQPELDEEARDWFRKLEAGDQEAISLWQWFRDESLVEFNRLYDLLRVQFDSYNGEA
                     FYNDKMDEVVTLLEDKDLLQESQGAQVVKLDKYGIENPALIKKSDGATLYITRDLAAAL
                     YRKRTYDFAKSIYVVGNEQAAHFKQLKAVLKEMDYDWSDDITHVPFGLVTKDGKKLSTR
                     KGNVILLEPTIAEAIKRAGDQIEAKNPDLPNKEAVAQAVGVGAIKFYDLKTDRLNGYDF
                     D"
     PFAM_domain     2285..2626
                     /aSDomain="DALR_1"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF05746.17"
                     /description="DALR anticodon binding domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg2_302_0135"
                     /evalue="5.10E-30"
                     /label="ctg2_302"
                     /locus_tag="ctg2_302"
                     /protein_end="563"
                     /protein_start="449"
                     /score="104.2"
                     /tool="antismash"
                     /translation="VQYAYARIQSILRKADFKADPAVGYYLDDAESWEIIKLIQNFPAA
                     IKRAADNFEPSIIAKFAISLAQAFNKYYAHNRILDQSPERDSRLALSYTTALVLKEALR
                     LLGVDAPDEM"
     CDS             complement(3345..3572)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: Bacteriocin_IIc"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg2_303"
                     /sec_met_domain="Bacteriocin_IIc (E-value: 4.1e-09,
                     bitscore: 33.6, seeds: 35, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNSLAFEQFELMDTEMLASIEGGVNWDRVFGGATVYGAATMAVCM
                     ATGPIGWGAGAAYLGLRAASGAYIGYGLAS"
     CDS             complement(4142..5083)
                     /locus_tag="ctg2_304"
                     /transl_table=11
                     /translation="MTKKTQPKRQIKYAVGKAAKKVGLLHAVRSISREKYAEKISASLF
                     YGILSSIAVNFFFQPGHVYSSGATGLAQVLSALSDRFVGFVIPVSVTFYTINIPLMILA
                     WFNLGHRFTIFTFITVTISSFFIQIMPQITLTSDPLINAIFGGLVMGTGIGYGLRSRIS
                     SGGTDIVSLYIRKKTGRAVGSISLMVNGTIMIFAGLLFGWQYALYSMVTIFVSSRMTDA
                     IFTKQKKMQATIITSQPERVTKQIHKRLHRGVTQINDAEGTYNHEKKAVLITIITREEF
                     NDFKYAMRKADPKAFVSVAEDVRILGRFVEDD"
     PFAM_domain     complement(4169..4330)
                     /aSDomain="DUF2179"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF10035.11"
                     /description="Uncharacterized protein conserved in bacteria
                     (DUF2179)"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg2_304_0137"
                     /evalue="1.90E-13"
                     /label="ctg2_304"
                     /locus_tag="ctg2_304"
                     /protein_end="305"
                     /protein_start="251"
                     /score="50.0"
                     /tool="antismash"
                     /translation="RGVTQINDAEGTYNHEKKAVLITIITREEFNDFKYAMRKADPKAF
                     VSVAEDVRI"
     PFAM_domain     complement(4346..4960)
                     /aSDomain="YitT_membrane"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF02588.17"
                     /description="Uncharacterised 5xTM membrane BCR, YitT
                     family COG1284"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg2_304_0136"
                     /evalue="1.40E-56"
                     /label="ctg2_304"
                     /locus_tag="ctg2_304"
                     /protein_end="246"
                     /protein_start="41"
                     /score="191.2"
                     /tool="antismash"
                     /translation="ASLFYGILSSIAVNFFFQPGHVYSSGATGLAQVLSALSDRFVGFV
                     IPVSVTFYTINIPLMILAWFNLGHRFTIFTFITVTISSFFIQIMPQITLTSDPLINAIF
                     GGLVMGTGIGYGLRSRISSGGTDIVSLYIRKKTGRAVGSISLMVNGTIMIFAGLLFGWQ
                     YALYSMVTIFVSSRMTDAIFTKQKKMQATIITSQPERVTKQI"
     CDS             complement(5076..6824)
                     /locus_tag="ctg2_305"
                     /transl_table=11
                     /translation="MKRSIYAGRVRSEHIGSQLTLKGWVGRRRDLGGLVFIDLRDREGI
                     MQLVINPEQVSKEIMDKAESLRTEYVIEVTGTAQAREQANDKLATGAVELQVSDLVILN
                     TSKTTPFEIKDDAEMTDDNRLRYRYLDLRRPSMLKNLKLRAKVTHSVRNYLDELEFIDV
                     ETPMLTKSTPEGARDYLVPSRVSQGHFYALPQSPQITKQLLMNAGLDRYYQIVKCFRDE
                     DLRGDRQPEFTQIDLETSFLDEEEIQEITEGLIARVMKETKGIDVTLPFPRMAYDDAMN
                     NYGSDKPDTRFDMLLQDLTDTVKDIDFKVFAQAPAVKAIVVKDAADKYSRKAIDKLTDV
                     AKQYGAKGLAWVKYMDGKVTGPIAKFLTAIADKLTERLQLVDNDLVLFVADSLEVANTT
                     LGALRTRLAKELDLIDQSQFNFLWVVDWPMFEWSEEEDRYMSAHHPFTLPTQETADQLE
                     GDLSKVRAVAYDIVLNGYELGGGSLRINHKDLQERMLKALGFSQESANEQFGFLLEAMD
                     YGFPPHGGLAIGLDRFVMILAGQDNIREVIAFPKNNKASDPMTQAPSLVAQKQLEELAL
                     QVQDHD"
     aSDomain        complement(5091..6824)
                     /aSDomain="TIGR00459"
                     /aSTool="tigrfam"
                     /description="aspS_bact: aspartate--tRNA ligase"
                     /detection="hmmscan"
                     /domain_id="TIGRFam_ctg2_305_0034"
                     /evalue="6.90E-233"
                     /identifier="TIGR00459"
                     /label="ctg2_305"
                     /locus_tag="ctg2_305"
                     /protein_end="578"
                     /protein_start="0"
                     /score="772.2"
                     /tool="antismash"
                     /translation="MKRSIYAGRVRSEHIGSQLTLKGWVGRRRDLGGLVFIDLRDREGI
                     MQLVINPEQVSKEIMDKAESLRTEYVIEVTGTAQAREQANDKLATGAVELQVSDLVILN
                     TSKTTPFEIKDDAEMTDDNRLRYRYLDLRRPSMLKNLKLRAKVTHSVRNYLDELEFIDV
                     ETPMLTKSTPEGARDYLVPSRVSQGHFYALPQSPQITKQLLMNAGLDRYYQIVKCFRDE
                     DLRGDRQPEFTQIDLETSFLDEEEIQEITEGLIARVMKETKGIDVTLPFPRMAYDDAMN
                     NYGSDKPDTRFDMLLQDLTDTVKDIDFKVFAQAPAVKAIVVKDAADKYSRKAIDKLTDV
                     AKQYGAKGLAWVKYMDGKVTGPIAKFLTAIADKLTERLQLVDNDLVLFVADSLEVANTT
                     LGALRTRLAKELDLIDQSQFNFLWVVDWPMFEWSEEEDRYMSAHHPFTLPTQETADQLE
                     GDLSKVRAVAYDIVLNGYELGGGSLRINHKDLQERMLKALGFSQESANEQFGFLLEAMD
                     YGFPPHGGLAIGLDRFVMILAGQDNIREVIAFPKNNKASDPMTQAPSLVAQKQLEELAL
                     QV"
     PFAM_domain     complement(5169..6461)
                     /aSDomain="tRNA-synt_2"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00152.22"
                     /description="tRNA synthetases class II (D, K and N)"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg2_305_0139"
                     /evalue="1.00E-104"
                     /label="ctg2_305"
                     /locus_tag="ctg2_305"
                     /protein_end="552"
                     /protein_start="121"
                     /score="350.1"
                     /tool="antismash"
                     /translation="DNRLRYRYLDLRRPSMLKNLKLRAKVTHSVRNYLDELEFIDVETP
                     MLTKSTPEGARDYLVPSRVSQGHFYALPQSPQITKQLLMNAGLDRYYQIVKCFRDEDLR
                     GDRQPEFTQIDLETSFLDEEEIQEITEGLIARVMKETKGIDVTLPFPRMAYDDAMNNYG
                     SDKPDTRFDMLLQDLTDTVKDIDFKVFAQAPAVKAIVVKDAADKYSRKAIDKLTDVAKQ
                     YGAKGLAWVKYMDGKVTGPIAKFLTAIADKLTERLQLVDNDLVLFVADSLEVANTTLGA
                     LRTRLAKELDLIDQSQFNFLWVVDWPMFEWSEEEDRYMSAHHPFTLPTQETADQLEGDL
                     SKVRAVAYDIVLNGYELGGGSLRINHKDLQERMLKALGFSQESANEQFGFLLEAMDYGF
                     PPHGGLAIGLDRFVMILAGQDNIREVIAFPKN"
     PFAM_domain     complement(6519..6767)
                     /aSDomain="tRNA_anti-codon"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF01336.27"
                     /description="OB-fold nucleic acid binding domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg2_305_0138"
                     /evalue="6.50E-14"
                     /label="ctg2_305"
                     /locus_tag="ctg2_305"
                     /protein_end="102"
                     /protein_start="19"
                     /score="51.8"
                     /tool="antismash"
                     /translation="TLKGWVGRRRDLGGLVFIDLRDREGIMQLVINPEQVSKEIMDKAE
                     SLRTEYVIEVTGTAQAREQANDKLATGAVELQVSDLVI"
     CDS             complement(7014..7433)
                     /locus_tag="ctg2_306"
                     /transl_table=11
                     /translation="VTSIEQLLNEEQTFSLSFQRDLPLQFQEQFWQMIAYLDRHEIPWF
                     NGEKASDHFMCQQFLGQQWDHDYQTVVLVFKPTERFLGWQYDEETDEWGISIQDIYGFS
                     WNHLADEADYSFEEIAEFQEEFVDTSNLLALFGKK"
ORIGIN
        1 ttatcttttg ccatttgcta atccttcgtt aatcttttct tccaaactct tggtcacata
       61 ctgcagaaga tcactagcat cctgcatttt ggaacggtag tcctgtacca aggggaggtt
      121 cgaaagttcc tgatttaagc gatcggcagc ctgacctgac tggtcggctg cccgattttt
      181 ttctagtttt tcgtagagaa ctgcctcctg ctgataggtc ttcatgtcgt gagccaaatg
      241 attcaaattt ggctgggcct ttaccttggc ctgcaccgct tgaaaggcct caacgctctc
      301 atgttgggcc atgagggtct gtagtttttt tacagcttgg tttaaatccg tcattagttc
      361 aattcttcct caatggtctg agccttgact gcatcttgac agataaccaa gagggtatca
      421 gcacctgcaa ccgttcccag aatatcactg cgaccttctc gatcaatgat attagccaag
      481 acatcggctt ctcccagctc tgtactaaga accagaataa aactagctcg tgaaatcttt
      541 ttaatatagt ccctggccac atccgacaga tgggaagtct cctcggctga caagctataa
      601 tagagctttc cattttcatc gcgacgtttg agcagaccaa tctctcgcaa atcccgagac
      661 agggtagctt gggtgacggc aatcccttgc cgtgccaggc tagccttgat ttcttcttgg
      721 gttcccactc gttcctcttg aataatggct cttatcttat tttgacgttc aattttattc
      781 atgtcatcct ctaaatctct caatttatac cttacccatt ataacaaaaa ggattggctt
      841 tttcacccta gataagtcgg atgaaatttg ccaaatgccc cagcaaaatc aagctattta
      901 tgttacaatg aaatgaatac tttcacagga gaatcacatg gatagtaaac ttattatcgc
      961 tcaagaaatc caggctgccc tgcccgatat ggagctggag gcgattgtta atttattgga
     1021 agttcctaaa aattctagca tgggagactt ggccttccca gttttttctt tggccaaggt
     1081 cttacgtaag gctccccaag ccattgccag cgaactggtt gaaaaaatcc agtccgataa
     1141 atttgaaaag gtccaagcag tcggtcctta tatcaatttc ttcctcaaca agcaggaaat
     1201 ttcccaggcc gttctagctg aggtcattgc caaggacaag gactatggcc agcaagaact
     1261 aggccagtgc aaaaatatca ccatcgatat gtccagtcct aatatcgcta agcccttctc
     1321 tgtcggtcac ctgcgttcga ccgttatcgg cgacagcctg gctaaaattt ttgaaaaaat
     1381 cggctataaa tctgttaaaa tcaaccactt aggggactgg ggcaagcagt ttggcatgct
     1441 gattgtcgcc tacaaaaaat ggggcgatga aggggctgtc agggccaccc ccatcaatga
     1501 gctcctgaaa ctctacgtcc gcatcaataa ggaagccgag agccagcctg aactggatga
     1561 agaagctagg gactggttcc gcaaactaga agcaggtgac caagaagcca tcagtctttg
     1621 gcaatggttc cgtgatgaaa gcctggtgga attcaaccga ctttatgacc ttttgagagt
     1681 ccagtttgac agctataatg gcgaagcctt ctacaatgac aagatggacg aagttgttac
     1741 tctcctggaa gataaggatc tcctccagga atcccaaggc gctcaggttg ttaagctgga
     1801 taaatacggt attgagaacc ctgccctcat taagaaatca gacggagcca ccctctatat
     1861 cacaagggac ttggcggcgg ccctctatcg taagcggacc tatgattttg ccaagtccat
     1921 ctatgtggtc ggcaacgaac aagcggccca cttcaaacag ctcaaggctg tgctcaagga
     1981 gatggactac gactggtcag atgacatcac ccacgttcct tttggcctgg tgaccaagga
     2041 tggcaagaag ctctcaaccc gtaagggcaa tgtcattctc ttggagccaa ccatcgccga
     2101 agccatcaag cgggctggtg accaaattga agccaagaac cccgacctcc ctaataaaga
     2161 ggccgttgcc caagctgtcg gtgtcggagc gattaagttc tacgatctca agactgaccg
     2221 cctcaatgga tatgactttg atctggatgc catggtttcc tttgaagggg aaactggccc
     2281 ctatgtccaa tacgcctatg ctcgtattca atccatcctt cgcaaggcgg actttaaggc
     2341 cgatccagct gtcggctact atttagatga tgctgaaagt tgggaaatta tcaagctcat
     2401 tcaaaacttc cctgctgcta tcaaacgagc tgccgataat tttgagccct ctatcattgc
     2461 taaattcgcg atcagcctag ctcaggcttt caataaatac tatgcccaca atcgtatctt
     2521 ggaccagagt ccagagcgtg acagccgtct agctctcagc tatacaacgg cactggttct
     2581 caaagaagcc ctgcgtcttc tgggcgtgga tgcaccagat gaaatgtaaa ctagagctta
     2641 taagaactta aaataccaca aatcatccca gagaagattc ttgatttatt aacgatcttc
     2701 tctgggcttt tcttatgaat tcatgtctaa ctttctattg tattgaatgg actcaaaaaa
     2761 aagacaaacc tcaaatgaag tttgtctcag atcaatggac agtttcaaag tagtccttag
     2821 tctcgcttaa gtttttatac tcttcgaaaa tcaaaatttt ccgtcgttaa ctcaccttgc
     2881 cgtaccccag tactgtcttc agttcgttgc ctcggctaat ttcgattttc attgagtatt
     2941 agtgaatcaa tccctcttat ttttgctgat ccatctggca atcccagcaa ccagtagcaa
     3001 agtcgtcaaa ccgaaagcta caagagctac aggggtgttc accatatcag gaaaaggatc
     3061 aattctgtta attaaacgca tgatagagag aacagcgaga agaagcaata atgaggattc
     3121 aagcctgata agtgaagtca tttcattgtt aattgcccac aaaaatcctg ggaaacaaag
     3181 caatgcaagt gctatgacaa gcaggtttga aagtttctct tcaccattgt taattactga
     3241 tatcataaga ccatttgcta taatgatcaa agctgtacaa ataataaaag aactttttct
     3301 tctcacgata accacctcaa aacgtagatt gatttaacag atgcttagct tgctagacca
     3361 taaccaatgt aggcacctga agctgcacga agacctagat aagctgctcc tgctccccaa
     3421 ccaattggac cagtagccat acaaacggcc atagttgctg caccataaac tgtagcacca
     3481 ccgaagacac gatcccaatt gactccacct tcaatgctag caagcatttc agtgtccata
     3541 agttcaaatt gttcaaaagc taaagaattc ataaacattc tcctttaaaa ttattttact
     3601 agccgactaa tatctttatt ttaatgtttt tttcaaaaaa ttaagggtta aaattaaaaa
     3661 atcaataatt gtgtgacgtt tttgaaatct aatgtataat tttctttcat tttaattaac
     3721 cttcaattaa aaatatccta aaatagatga aattatagtt gctacagaca cttacttatt
     3781 agagcacttt ttattatgta actgaaaagc ctttattgta gcctagaagg aaacttttaa
     3841 gaccatcgaa aaatccgata gtcctatttt gtacttatat gaaaattgaa aacagacgaa
     3901 gaaagaacca tctattagtg aaaactatcg tttaactaat agaacgtcag caactatggt
     3961 tgactgacta gtttcttcac taacctcata aagttggtag aaacgaccga cttatatgag
     4021 gtgtcgttcg aactgcagac tgtactgaag tacggcaaag tgagttaacc aggcgactcg
     4081 agaaaagaaa agccgattac gctttgcttg atgtatcttg agattttcga agagtattat
     4141 tctagtcatc ttccacaaaa cgtcctagga tacggacatc ctcagcaaca gaaacgaaag
     4201 ccttggggtc agcctttcgc atagcatatt tgaaatcatt aaattcttct cgggtgatga
     4261 tggtaatcag taccgctttt ttctcatgat tgtaggtgcc ttcggcatca ttaatttggg
     4321 tcacgccccg gtgcagtcgc ttatgaattt gcttggttac tcgttcaggc tggctggtaa
     4381 taatcgtggc ctgcatcttc ttttgcttgg tgaaaatggc atctgtcatc cgactggaga
     4441 caaagatggt caccatggaa taaagggcat actgccagcc gaagaggaga ccagcaaata
     4501 tcatgatggt tccattgacc atgagggaga tactgccgac agcccgcccc gttttcttac
     4561 ggatatagag gctgacaatg tcggttcctc cgctagaaat ccgcgaccgc agtccatagc
     4621 caatccccgt ccccatgacc agaccaccaa agatagcatt aatcaaggga tcacttgtca
     4681 aggtaatctg gggcatgatt tggataaaga aggaactgat cgttaccgtg atgaaggtaa
     4741 aaatggtaaa gcggtggccc aagttgaacc aggctaaaat catcagcgga atattgatgg
     4801 tgtaaaaggt taccgaaacc ggtatcacaa agccgacaaa gcggtcactc agagccgata
     4861 ggacctgagc caaaccagtc gccccgctgg aatagacgtg gcctggttga aagaagaaat
     4921 tgaccgcaat actggataaa atcccataaa agagcgaggc cgaaattttc tcggcatact
     4981 tttcccgcga aatactgcgg accgcatgta agagaccaac cttcttagct gccttaccga
     5041 ccgcatactt gatttggcgt ttaggctgtg tttttttagt catggtcttg cacttgcaga
     5101 gctagttctt ccaattgttt ttgggcaacc aggctaggag cctgggtcat tgggtcagaa
     5161 gccttgttat tcttagggaa ggcaatgact tcacgaatgt tgtcttggcc agccaaaatc
     5221 ataacaaagc ggtccagacc gatagccagt ccaccatgtg gtgggaagcc gtaatccatg
     5281 gcttctagca ggaagccaaa ttgctcattg gcagattctt ggctaaagcc aagcgccttg
     5341 agcatgcgct cctgcagatc cttgtgatta atccgcaagc taccgccacc caattcatag
     5401 ccgttgagga caatatcgta ggcaaccgct ctgaccttgg acaggtcgcc ttccagttgg
     5461 tcggctgttt cttgagttgg cagggtgaag gggtggtggg ctgacatgta gcggtcctct
     5521 tcttccgacc attcaaacat tggccagtca accacccaga ggaagttgaa ttggctttgg
     5581 tcaatcaagt ctaattcctt agctaggcgt gtccgcaggg cacccagggt ggtgttagcg
     5641 acttctagac tatcggccac aaagaggacc aaatcattgt caactaactg taaacgctct
     5701 gtcaacttat cagcaatcgc tgtcaagaat ttggcgatag gtcctgtcac tttgccgtcc
     5761 atatacttga cccaagctag acctttggcc ccatattgtt tagcgacatc tgtcaacttg
     5821 tcaatggctt tacgagaata cttatcagct gcatccttaa ccacaatagc cttaacggct
     5881 ggagcttggg caaagacctt gaagtcaatg tccttgacag tatctgtcaa gtcctgtaaa
     5941 agcatgtcaa aacgggtatc tggcttgtca gacccataat tgttcatggc atcatcataa
     6001 gccattcttg ggaaaggtag ggttacatca atccccttag tttccttcat gacccgagca
     6061 attagacctt cggtaatttc ttggatttct tcctcatcta ggaatgaggt ttccaagtca
     6121 atttgggtaa actcaggttg gcggtccccc cgtaagtctt cgtcacggaa gcatttgacg
     6181 atttgatagt aacggtcaag accagcattc atcagcaact gcttggtaat ttgtggactc
     6241 tgaggaaggg catagaagtg gccttggcta acccgacttg gcaccaagta atccctggcc
     6301 ccttctggtg ttgacttggt caacatgggt gtttccacat caatgaattc cagctcatct
     6361 aggtagttgc gaacgctgtg ggttaccttg gcccgcagtt tgaggttctt gagcatactt
     6421 ggacggcgca agtccaaata gcggtaacgc agacgattat catcggtcat ttccgcatca
     6481 tccttgattt caaaaggagt tgtcttagaa gtgttgagaa tgactaggtc gctgacttgc
     6541 agttccacag ctcctgttgc caacttatca ttggcttgct cgcgggcttg agcggtgcct
     6601 gtcacctcaa tcacgtactc ggtccttagg ctctcagcct tatccatgat ttccttagag
     6661 acttgttctg gattgatgac cagctgcata atcccttcac ggtctctcag atcaataaaa
     6721 accaaaccgc ctaggtcacg gcgacggccc acccaaccct tgagggtcag ttgacttcca
     6781 atatgttcag agcgaacacg tccggcatag atactacgtt tcattgtttc tcccaagccc
     6841 tggtccaacc ggcagggctt attcctttct ccttgggtct tttttacatt cctacctatt
     6901 atagcaaaaa gcatagtaaa accccaccca ttgggcggag tttttcaagc tagtttgctc
     6961 aggcttcttt aaggcggctg gagcttggcc taagaattta gctagacttg ttcctacttc
     7021 ttaccaaaaa gagctaggag attgctggtg tcgacgaact cctcctgaaa ttcggcgatt
     7081 tcttcaaagc tgtagtcggc ctcgtcagct agatggttcc agctaaagcc atagatatct
     7141 tgaatggaga taccccattc atccgtctct tcgtcatact gccaacccag aaaacgctct
     7201 gtgggcttaa agaccaagac gactgtttga taatcatggt cccactgttg gcccaaaaat
     7261 tgctggcaca taaaatggtc gctggccttt tccccattga accagggaat ttcatggcga
     7321 tccaaatagg caatcatctg ccagaactgc tcttgaaatt gcaagggcaa atccctctgg
     7381 aaagacaggc taaaggtctg ctcctcgttt aataactgtt caatacttgt cac
//
