LOCUS       c00002_NZ_UHFA..        8400 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  NZ_UHFA01000002.1 Streptococcus downei MFe28 strain NCTC 11391,
            whole genome shotgun sequence.
ACCESSION   NZ_UHFA01000002
VERSION     NZ_UHFA01000002
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 6.1.1
            Run date     :: 2024-03-14 16:14:09
            Original ID  :: NZ_UHFA01000002.1
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 113130
            Orig. end    :: 121530
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     CDS             1..654
                     /gene_functions="regulatory (smcogs)
                     SMCOG1133:Transcription regulator, crp (Score: 74; E-value:
                     1.7e-22)"
                     /gene_kind="regulatory"
                     /locus_tag="ctg2_109"
                     /transl_table=11
                     /translation="MTKKALEYYLNKYRLDTIFPQPYIKQLQLMTYDKGQAICQQGQVL
                     EHLFYFIEGHIKIVRRLFNGKEHILETQNQPTLIGDIELMNDQTSVSSVIALEPSLIIQ
                     LPLTNREELYQDPLFLYQIGRQLAQKLEQQNIISSTNISYSVKERLATYILAQETQGVF
                     QLQPSVLADIFGTSYRHLSRVAKQLQDQNIIEKIAFKTYKIVNRAQLEKTKIED"
     protocluster    1..8400
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[117708:117969](-)"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193)"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(4579..4839)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193)"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
     cand_cluster    1..8400
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193)"
                     /kind="single"
                     /product="RiPP-like"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..8400
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="RiPP-like"
                     /region_number="3"
                     /rules="(strepbact or Antimicrobial14 or Bacteriocin_IId or
                     BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or
                     Lactococcin or Antimicrobial17 or Lactococcin_972 or
                     Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or
                     TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or
                     TIGR03975 or DUF692 or TIGR01193)"
                     /tool="antismash"
     PFAM_domain     91..345
                     /aSDomain="cNMP_binding"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00027.31"
                     /description="Cyclic nucleotide-binding domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg2_109_0027"
                     /evalue="1.10E-15"
                     /label="ctg2_109"
                     /locus_tag="ctg2_109"
                     /protein_end="115"
                     /protein_start="30"
                     /score="57.6"
                     /tool="antismash"
                     /translation="TYDKGQAICQQGQVLEHLFYFIEGHIKIVRRLFNGKEHILETQNQ
                     PTLIGDIELMNDQTSVSSVIALEPSLIIQLPLTNREELYQ"
     PFAM_domain     442..636
                     /aSDomain="HTH_Crp_2"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF13545.8"
                     /description="Crp-like helix-turn-helix domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg2_109_0028"
                     /evalue="3.00E-09"
                     /label="ctg2_109"
                     /locus_tag="ctg2_109"
                     /protein_end="212"
                     /protein_start="147"
                     /score="36.8"
                     /tool="antismash"
                     /translation="ERLATYILAQETQGVFQLQPSVLADIFGTSYRHLSRVAKQLQDQN
                     IIEKIAFKTYKIVNRAQLEK"
     CDS             733..1347
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1275:peptide deformylase (Score: 137.5; E-value:
                     4.6e-42)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg2_110"
                     /transl_table=11
                     /translation="MSPQEKIIKASHLIDMSDIIREGNPTLREVAKDVELPLSDEDIIL
                     GEKMMQFLKNSQDPVMAEKMGLRGGVGLAAPQLDISKRIIAVLVPNPEDKEGNPPAQPY
                     SMQEVMYNPRIVSHSVQDAALADGEGCLSVDREVPGYVVRHSRVTVEYVDKNGDKQKIK
                     LRGYNSMVVQHEIDHTNGIMFYDHINEDNPFEIKEGMLIIQ"
     PFAM_domain     781..1305
                     /aSDomain="Pep_deformylase"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF01327.23"
                     /description="Polypeptide deformylase"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg2_110_0029"
                     /evalue="1.80E-40"
                     /label="ctg2_110"
                     /locus_tag="ctg2_110"
                     /protein_end="191"
                     /protein_start="16"
                     /score="138.2"
                     /tool="antismash"
                     /translation="SDIIREGNPTLREVAKDVELPLSDEDIILGEKMMQFLKNSQDPVM
                     AEKMGLRGGVGLAAPQLDISKRIIAVLVPNPEDKEGNPPAQPYSMQEVMYNPRIVSHSV
                     QDAALADGEGCLSVDREVPGYVVRHSRVTVEYVDKNGDKQKIKLRGYNSMVVQHEIDHT
                     NGIMFYDHINED"
     aSDomain        781..1329
                     /aSDomain="TIGR00079"
                     /aSTool="tigrfam"
                     /description="pept_deformyl: peptide deformylase"
                     /detection="hmmscan"
                     /domain_id="TIGRFam_ctg2_110_0009"
                     /evalue="1.90E-38"
                     /identifier="TIGR00079"
                     /label="ctg2_110"
                     /locus_tag="ctg2_110"
                     /protein_end="199"
                     /protein_start="16"
                     /score="129.6"
                     /tool="antismash"
                     /translation="SDIIREGNPTLREVAKDVELPLSDEDIILGEKMMQFLKNSQDPVM
                     AEKMGLRGGVGLAAPQLDISKRIIAVLVPNPEDKEGNPPAQPYSMQEVMYNPRIVSHSV
                     QDAALADGEGCLSVDREVPGYVVRHSRVTVEYVDKNGDKQKIKLRGYNSMVVQHEIDHT
                     NGIMFYDHINEDNPFEIKEG"
     CDS             complement(2044..2673)
                     /gene_functions="regulatory (smcogs) SMCOG1057:TetR family
                     transcriptional regulator (Score: 80.5; E-value: 3.4e-24)"
                     /gene_kind="regulatory"
                     /locus_tag="ctg2_111"
                     /transl_table=11
                     /translation="MAEKKVRSPRQERSIEKREKILKTAKDLFSEKVYFNVTTNEIAKT
                     AGLSVGTLYSYFASKEDILTSLLERYNQAFVDRVFDELSSWESLELFKQAPKDWLNRLI
                     DQLLQTEDKKFHAQVEMLAYAVPEAQTLLEEHNEKMKALTYQCFLDYQEKKSDAKLKIL
                     SLVVFDFTSALVDELLYHNHSDREFTQVKKTGVDSLYRIIASYLDD"
     PFAM_domain     complement(2479..2613)
                     /aSDomain="TetR_N"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00440.25"
                     /description="Bacterial regulatory proteins, tetR family"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg2_111_0030"
                     /evalue="4.40E-14"
                     /label="ctg2_111"
                     /locus_tag="ctg2_111"
                     /protein_end="65"
                     /protein_start="20"
                     /score="52.1"
                     /tool="antismash"
                     /translation="ILKTAKDLFSEKVYFNVTTNEIAKTAGLSVGTLYSYFASKEDILT
                     "
     CDS             2851..4251
                     /gene_functions="transport (smcogs) SMCOG1005:Drug
                     resistance transporter, EmrB/QacA (Score: 309.8; E-value:
                     3.9e-94)"
                     /gene_kind="transport"
                     /locus_tag="ctg2_112"
                     /transl_table=11
                     /translation="MTKTKKMLLTLAMCLGVFLVTLDTTIMNITIPAIQNSFSISLDKL
                     SWAINVYTIIFASFTIPLSKLADIFGKGRFFVLGLILFGGGSLISGFSADFNWLLAGRL
                     IASFGAAILLPVGNTLGISTWSVKDRVKVVAALGLTQGGAAAIGPTLGGLLTDSLSWHW
                     IFFVNLPIVLLAFLIVLFCYHFQGEERIPTKIDWVGSLLSMISLFAVSLGIIKVRDWGF
                     WNGKSLSCFAVFLLALIAFIFLERRIKHPMIKLELFKFREFSASTFIATVVQFFYVGVL
                     VILPTFFTNMQGKTELDAALILLPMSIIVFIFGGLGSLLINKLGPRILVLVGLGSILIA
                     YILLVTVDPAKTWEMTAATVILGIGFGTIAGPVNVLAASSLQGELLTSSQSVLGVVRQI
                     GSVLAVSVFISMVTNNLKTLHTYTPSTMTDAYISIYKIWIPFMVAMLVLTLLFPKRKDY
                     LKGVADKK"
     PFAM_domain     2890..4062
                     /aSDomain="MFS_1"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF07690.18"
                     /description="Major Facilitator Superfamily"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg2_112_0031"
                     /evalue="1.90E-43"
                     /label="ctg2_112"
                     /locus_tag="ctg2_112"
                     /protein_end="404"
                     /protein_start="13"
                     /score="148.9"
                     /tool="antismash"
                     /translation="CLGVFLVTLDTTIMNITIPAIQNSFSISLDKLSWAINVYTIIFAS
                     FTIPLSKLADIFGKGRFFVLGLILFGGGSLISGFSADFNWLLAGRLIASFGAAILLPVG
                     NTLGISTWSVKDRVKVVAALGLTQGGAAAIGPTLGGLLTDSLSWHWIFFVNLPIVLLAF
                     LIVLFCYHFQGEERIPTKIDWVGSLLSMISLFAVSLGIIKVRDWGFWNGKSLSCFAVFL
                     LALIAFIFLERRIKHPMIKLELFKFREFSASTFIATVVQFFYVGVLVILPTFFTNMQGK
                     TELDAALILLPMSIIVFIFGGLGSLLINKLGPRILVLVGLGSILIAYILLVTVDPAKTW
                     EMTAATVILGIGFGTIAGPVNVLAASSLQGELLTSSQSVLGVVRQIGSVLA"
     CDS             complement(4579..4839)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: Bacteriocin_IIc"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg2_113"
                     /sec_met_domain="Bacteriocin_IIc (E-value: 1.1e-10,
                     bitscore: 38.7, seeds: 35, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDTLALDNFEAANMSDLSEVQGGTNPTRCVVGIAGEGVQSGIAGA
                     AALGAVGLAVGGPVGAYGGAHLGFFLGFIGGSLKGTADYCF"
     PFAM_domain     complement(4639..4821)
                     /aSDomain="Bacteriocin_IIc"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF10439.11"
                     /description="Bacteriocin class II with double-glycine
                     leader peptide"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg2_113_0032"
                     /evalue="9.30E-09"
                     /label="ctg2_113"
                     /locus_tag="ctg2_113"
                     /protein_end="67"
                     /protein_start="6"
                     /score="35.3"
                     /tool="antismash"
                     /translation="DNFEAANMSDLSEVQGGTNPTRCVVGIAGEGVQSGIAGAAALGAV
                     GLAVGGPVGAYGGAHL"
     CDS             complement(5488..5670)
                     /locus_tag="ctg2_114"
                     /transl_table=11
                     /translation="MESNVFDKFESVQTIDLSKQIGGSIVIGYDWGLSLARAFGNLYKG
                     GFSGGGGGGGSFGGR"
     CDS             6009..6698
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Abi"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg2_115"
                     /sec_met_domain="Abi (E-value: 3e-15, bitscore: 53.4,
                     seeds: 823, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKTLLNKLKWIALAFAFLALDFFAQALFVIKKDLSNTGTAIIASL
                     GLTAFAALAWFLLWLLKEPLNFKKIRWGMYGLYVGLGVPILFAIKSIGGILLMLMSNTS
                     TSANQAAIDNLGMPIYLYFVFACVFAPIFEEAIFRKCLFEKLFGFEGWQKWLGWIVTSI
                     LFGFIHLYSSPSNLLSPGLWIIYGGMGLAIGFVTMMNKRIEFGYSLHVFNNLIAVLFTF
                     LMQLLTH"
     PFAM_domain     6366..6656
                     /aSDomain="Rce1-like"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF02517.18"
                     /description="Type II CAAX prenyl endopeptidase Rce1-like"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg2_115_0033"
                     /evalue="4.90E-14"
                     /label="ctg2_115"
                     /locus_tag="ctg2_115"
                     /protein_end="216"
                     /protein_start="119"
                     /score="52.6"
                     /tool="antismash"
                     /translation="YLYFVFACVFAPIFEEAIFRKCLFEKLFGFEGWQKWLGWIVTSIL
                     FGFIHLYSSPSNLLSPGLWIIYGGMGLAIGFVTMMNKRIEFGYSLHVFNNLI"
     CDS             complement(6828..7427)
                     /locus_tag="ctg2_116"
                     /transl_table=11
                     /translation="MSFVTTIKNLFTKEEKTMKNILFIVGSLREGSFNHQMAEQAEQVL
                     AGKANVSYLDWGQVPILNQDLETPVLPAVQAVRDAVEAADAIWIFSPVYNFSIPGSVKN
                     LLDWLSRAKDLSDTTGKSAIDSKVTTVSLVANGGTDQAAEIYRHLLPFIRTNFVDEVTT
                     SRVNDSAWADGKFVADEATLAQLQKQAEAFLAATAE"
     PFAM_domain     complement(6966..7370)
                     /aSDomain="FMN_red"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF03358.17"
                     /description="NADPH-dependent FMN reductase"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg2_116_0034"
                     /evalue="1.90E-24"
                     /label="ctg2_116"
                     /locus_tag="ctg2_116"
                     /protein_end="154"
                     /protein_start="19"
                     /score="86.3"
                     /tool="antismash"
                     /translation="NILFIVGSLREGSFNHQMAEQAEQVLAGKANVSYLDWGQVPILNQ
                     DLETPVLPAVQAVRDAVEAADAIWIFSPVYNFSIPGSVKNLLDWLSRAKDLSDTTGKSA
                     IDSKVTTVSLVANGGTDQAAEIYRHLLPFIR"
     CDS             complement(7498..7935)
                     /gene_functions="regulatory (smcogs) SMCOG1135:MarR family
                     transcriptional regulator (Score: 115.7; E-value: 1.8e-35)"
                     /gene_kind="regulatory"
                     /locus_tag="ctg2_117"
                     /transl_table=11
                     /translation="MTEFKNSAVKSMVVMRKAFRTIDSRVSATFRDFDLTPAQFSVLDV
                     LHAKGPMRIGDLIASILSTSGNMTIVIKNMEKNGWVKRTVSKKDHRAYIISITDKGRKL
                     IKKALPAHIEAVEEAFDVLTQAEQEELIELLKKFRTLADKD"
     PFAM_domain     complement(7660..7833)
                     /aSDomain="MarR"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF01047.24"
                     /description="MarR family"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg2_117_0035"
                     /evalue="1.10E-12"
                     /label="ctg2_117"
                     /locus_tag="ctg2_117"
                     /protein_end="92"
                     /protein_start="34"
                     /score="47.7"
                     /tool="antismash"
                     /translation="LTPAQFSVLDVLHAKGPMRIGDLIASILSTSGNMTIVIKNMEKNG
                     WVKRTVSKKDHRA"
     CDS             complement(8254..8400)
                     /locus_tag="ctg2_118"
                     /transl_table=11
                     /translation="MELMIKWDDQSKDEHFDYRLEFSGKQALLATVALCGTVLLGKALF
                     SKK"
ORIGIN
        1 atgacgaaaa aggccctaga gtattattta aacaagtatc gactggacac gattttccct
       61 caaccctata tcaaacaact ccagctcatg acctatgata aggggcaggc catctgtcaa
      121 caaggacaag ttctagagca tctcttttat tttattgagg gccatattaa gattgtccgc
      181 cggcttttta atggtaagga gcatatccta gaaacccaga atcagccgac cctaattggg
      241 gatattgagc ttatgaatga ccagactagc gtgtcatctg tcattgctct tgaacccagc
      301 ctgattattc aactgcctct gaccaatcgg gaagaacttt accaagatcc gctctttctc
      361 taccagattg gccgccaatt ggcccaaaaa ttggagcaac aaaatattat ctcttccacc
      421 aatatttcct attcggtcaa ggagcgcttg gccacctaca ttctagctca ggagacccaa
      481 ggtgtcttcc agctccaacc cagtgtccta gctgatattt tcgggacttc ttaccgccac
      541 ctgagtcgag tggccaagca gttacaggat cagaatatta ttgaaaaaat agcttttaag
      601 acttacaaaa tcgtcaaccg agcccaactg gaaaaaacta agattgaaga ctagggggcc
      661 ggcctttcat tctccttgct ttcatgctat actgaattca agcataattt ctacaattaa
      721 agaggtttca ccatgtcacc acaagaaaaa attattaaag ccagccatct gattgatatg
      781 tccgatatta tccgcgaagg caacccaacc ctgcgggaag ttgccaaaga tgtggaactg
      841 ccactttccg atgaagatat tatcctaggc gaaaaaatga tgcagtttct caagaattcc
      901 caagaccctg tcatggctga aaaaatgggc ctgcgtggtg gggtcggttt ggccgccccc
      961 caattggaca tttctaagcg aattatcgct gtgctagtac ccaatccaga agacaaagaa
     1021 ggcaatccgc ctgctcaacc ttacagtatg caggaagtca tgtataatcc tcggattgtt
     1081 tctcactctg ttcaggatgc tgctctagct gacggtgaag gctgtctgtc cgttgaccgt
     1141 gaagttcccg gctatgtggt tcgtcactcc cgagtgaccg tcgaatatgt tgataaaaat
     1201 ggcgacaagc aaaaaatcaa acttcggggt tataactcta tggtggtcca acacgaaatc
     1261 gaccacacca acggcatcat gttctacgat catatcaacg aagacaaccc cttcgaaatc
     1321 aaggaaggta tgttgattat tcaataaaaa caagctccga catcatagtc agggcttatt
     1381 ttaggctcta tatttatttt ttactcaatg aaaaaacgaa aagacatatc cgattatttc
     1441 tctggcttgt ctttgattca acttaaggca aactggagag aatttggttt gcctttttga
     1501 atagccaaat aagccggctg ggacagaagt cctagcttgg tgacttttcc aatattaaca
     1561 ctttgacgca gtggttgatt tgcgatgatg ggcttgatgc tttagcattt agcccaccac
     1621 ataccagcga agcggcggca tgatgtggca aagtcatcta gctactcaaa gcagctgatg
     1681 acgcagtagg tgactgctgt ctttgctcct gagatggtac agcagacagc tagtcaccct
     1741 tgctggggta gagactacga aggttttgac aaccgtcaaa gcccttctgt cctacttcct
     1801 aacagcaagc accatcgtgc ttgcttagcc accccactag ctacggcaaa actataaggt
     1861 caatagtctt gtctctgcat cgtgtccaag acatgccagt gaaacggcgg taaagtactt
     1921 atcccctttc aggataggtc aaacagtctg ggagactgtt ggagaaaacc aagtcaactg
     1981 tgtgggggtg agactacgaa attggcggct ttgccgtagc aagactgtct cactcccttt
     2041 catttaatca tcgagataag atgcaattat acgataaaga ctgtccacac cggtcttttt
     2101 tacttgcgta aattctcggt cagaatggtt atggtagagc agttcatcga ctagggccga
     2161 ggtaaaatca aaaaccacca aggagaggat tttcagttta gcatccgact ttttctcttg
     2221 ataatccaag aaacactggt aggttagagc tttcattttt tcattgtgct cttccagaag
     2281 agtctgggcc tcaggtacag cataggccaa catttccact tgagcatgga acttcttatc
     2341 ctcggtttgc aagagctggt caatcaacct gttcagccag tctttaggag cttgcttgaa
     2401 tagttccaga gattcccagc tactcaattc atcaaagacc cgatcaacaa aggcctgatt
     2461 atagcgttct agcaggctgg tcagaatatc ttctttgctg gcaaaatagg aatagagagt
     2521 ccccacagaa aggcctgcag tcttggcaat ttcattggtt gtcacattaa aatagacctt
     2581 ttctgaaaac agatccttgg ccgtctttaa aatcttttcc cgcttttcaa tgcttctctc
     2641 ctgccgagga gagcggacct tcttttctgc catcgcttat tccctctatt gtaaaaatta
     2701 atctaattat agcacatgag cgaataattg ggataaatct caaataaata tgagcaaaaa
     2761 ctcattttta tcttgacaag cttctcggac aggattataa tacaaaataa atatgagtat
     2821 taactcatgt tttataaaaa ggaggtcact atgacaaaaa caaaaaagat gttactgacc
     2881 ctagccatgt gtctgggtgt ctttttggta acactggata ccaccatcat gaatattacc
     2941 atcccagcta tccagaacag ctttagtatc agccttgaca agctatcttg ggctatcaat
     3001 gtttatacca tcatctttgc cagctttact attcccttga gtaagttggc cgatatcttt
     3061 ggtaaagggc gtttcttcgt cctgggtttg attctatttg gcggtggtag tctgatttca
     3121 ggcttttcag ccgactttaa ctggctttta gcggggcgcc tcatcgctag cttcggagct
     3181 gctattctcc tacctgtcgg taatacccta ggtatttcaa cctggtcggt caaggaccgg
     3241 gtcaaggtgg tcgctgctct tggtctgacc caaggtggcg ctgccgctat tggtcctacc
     3301 ctgggtggtt tgctgacgga cagcctatcc tggcactgga ttttctttgt caatctgccc
     3361 attgtcctgt tggcctttct tatcgttctt ttctgctatc acttccaagg cgaagaacga
     3421 atcccaacca agattgactg ggtaggcagt ctcctgtcta tgattagtct attcgctgtt
     3481 tccctaggca tcatcaaggt gcgggactgg ggcttctgga atggcaagag tctgagctgt
     3541 tttgccgtct tcctgctggc tctcatcgcc tttatcttcc tagaaagacg gattaagcac
     3601 ccaatgatta agctggaact ctttaaattc cgtgaatttt cagcttccac cttcattgcc
     3661 acagttgtgc aattcttcta cgttggtgtc ctcgtcatcc tgccgacctt tttcaccaat
     3721 atgcagggta agacggagct tgatgccgct ctgattttgc tacccatgtc catcatcgtc
     3781 tttatctttg gcggcctggg tagtctgctc atcaataaac tgggcccacg gattttggtc
     3841 ttagtcggtt tgggtagtat tctgattgcc tacattttgc tagtcaccgt tgaccccgcc
     3901 aagacttggg aaatgactgc tgctacggtt attcttggta ttggctttgg gactatcgct
     3961 ggtccagtca atgtcctagc tgcctcgagc ctgcaagggg agcttctgac ctcgtcccaa
     4021 agtgttctag gcgtcgttcg gcaaattggc tctgttctgg ccgtctcggt cttcatctct
     4081 atggtgacca acaacctcaa aactctccat acctacaccc caagtaccat gaccgatgcc
     4141 tacatctcca tctacaagat ttggattcct ttcatggtcg ctatgctggt tttgaccctg
     4201 ctctttccta agagaaaaga ttatttgaaa ggagtggctg ataaaaaata acattgaaaa
     4261 ctccctctag gactaaatct ctagggggag cttgtttatc taaaaaatat gatttctagc
     4321 ttaatatgcc ctgtggtttt atagttcccc ataatgcata aacaccaaga gctgcaccta
     4381 aagggggata tagtgttgca acagctacag gaaatggcgt cttgccaaga aaagcctcct
     4441 tgaacctcag aaagttcact catattggct gcttcaaaat tgtctaatgc tactgtattc
     4501 atcatatttc cttcttctaa aagtattaaa ctagtggcct tgagcagatt ctttctctag
     4561 taaaatttca tccatctact aaaagcagta atctgctgtt cctttcaacg agcccccaat
     4621 aaatcctagg aagaagccta aatgagctcc tccatatgca ccaacaggac ctcctactgc
     4681 aagacctacc gcacccagtg cagctgcacc agcaatccca gattgtacgc cttctcctgc
     4741 tattcccact acacatcgag tcggattcgt accaccttga acttcagaga ggtcgctcat
     4801 attggctgct tcaaaattgt ctaatgctaa tgtatccata acttttcttc tcctttaacc
     4861 tttcaatcga ttttatacgg ctgtaacgac tgggatagta atagcttctc ctgataagta
     4921 gggtcttgct ctcaaaactc caattccatt gccacgatag acaccatcat ctagataacc
     4981 accatatagc gttctaccaa caattcggcc ccccctgaaa ctctgacaag tttgtcttat
     5041 ctactgtctt aaagtctgca aatacttttg tatctaaatt tatcataatt gtctcctttt
     5101 cattagctat caaaatttaa ttaataatag ggaaatggcg gccaaattcc taccaccggt
     5161 ggataaaact tagctgggtc tttacctagt gaaatctctt cgtggccaag ctcagttaac
     5221 cttttggagc catctccttg aatctttgat aatcttttag aacttactgt ctcaaaacta
     5281 taaagaactg gttgatttaa tatctttgcc atcagatact ttcccttctg tttcggccat
     5341 gccagaagat ttacgaatct catactagta ttgactttct ttaattatca gggagaagta
     5401 tcttacccaa gagtattaga aaattgatta ctcaggactt tatctgtttc tcctatttaa
     5461 tttaagataa actcattggt aggtgcatca gcgaccgccg aagctcccac cacctcctcc
     5521 tcctcctgaa aatccacctt tataaagatt tccaaatgct cgagctaggc tcagtcccca
     5581 atcataacca ataacgatac ttccaccgat ttgtttagac aaatctatgg tttgaacaga
     5641 ttcaaattta tcaaatacat ttgattccat atagttcgtc ctttcatttt tatgtttgtt
     5701 atactatcac ttatactttt cttgattaag gattccaaca ggtttttgat tagaatgtta
     5761 agatattgca aaaattacgt aaaagttctg ttaattttta ttcggttttc cctgactcct
     5821 gtaaaaatag gttgaatcac tattttttca atctccgtaa gatttctcag gagggtaaaa
     5881 tcttgatttt tctcttctta aaatttgcag gaaaatttct agctcccttg ctttcttccc
     5941 tcactttcgt taaactagta ggcagttgcc ggctacgctg gattaagaaa ttggattgga
     6001 ggggtctcat gaaaacccta ctaaataaac ttaaatggat tgctcttgcc tttgcattcc
     6061 ttgcacttga tttcttcgct caggctttat ttgtcatcaa aaaggattta tcaaatactg
     6121 gtactgccat catcgctagt ctgggcttga ctgcctttgc tgctctagct tggttcctcc
     6181 tttggctatt aaaagaacca ctcaacttta agaagattcg ctggggcatg tatggtctat
     6241 atgtcggctt aggtgtccct atcctttttg ccattaagtc tatcggcggt atcttgctga
     6301 tgctgatgag taacacaagc acctctgcta atcaggctgc cattgataac ctaggtatgc
     6361 ccatctatct ctattttgtc tttgcttgtg tctttgcccc gatttttgaa gaagctattt
     6421 tccgcaagtg cctctttgaa aagctctttg gctttgaggg ttggcaaaaa tggctgggct
     6481 ggattgtcac atccatcctc tttggtttta tccacctcta tagcagccct tccaacctcc
     6541 tatctccagg tctctggatt atctatgggg gcatgggcct tgcgattggt tttgtaacca
     6601 tgatgaataa gcggattgaa tttggctaca gcctccatgt ctttaacaac cttatcgccg
     6661 tcctctttac cttccttatg caactgctca cccattaatt aaatggaagg taaccttcta
     6721 aaattataaa aagtcctagc tctggaaaag tcccagtagc ccgaccaaac gaaaactcct
     6781 caagcttatt ctgagcctga ggagtttctt atgctttaat cttattatta ttcagctgta
     6841 gctgccaaaa atgcttctgc ttgcttttgg agttgggcaa gggttgcttc gtcagcgacg
     6901 aatttgccat cagcccaagc ggaatcgttg acacgagagg tggttacctc atcaacgaag
     6961 ttggtccgaa tgaatggcag gaggtggcgg tagatttctg ctgcttggtc ggtaccaccg
     7021 ttagctacga gggaaacagt tgtgaccttg gagtcaatgg ctgatttacc agttgtatct
     7081 gacaaatctt tagcacggga caaccagtcc aagaggttct tgacagaacc tgggattgag
     7141 aagttgtaaa cgggtgagaa aatccagata gcatctgccg cttcgacagc atcacgaaca
     7201 gcttgaactg ctggcaagac tggggtttcc aggtcttggt tcaagatggg aacttgtccc
     7261 caatcaaggt aggaaacatt tgcttttcca gccaaaactt gctcggcttg ctctgccatt
     7321 tggtggttga aggagccctc gcgcaaagag ccgacgataa agagaatatt tttcatagtt
     7381 ttttcttcct ttgtaaatag gtttttaata gtagtaacga atgacatcat aattcctttt
     7441 tatttatcac tatgtagtaa taatagcagc aaattaaagg cctgtccaaa aatatgctca
     7501 gtccttatcc gcaagggttc taaatttttt caagagctca atgagttctt cctgttcagc
     7561 ttgcgtcaaa acatcaaagg cctcttctac cgcttcaata tgagctggca gggctttttt
     7621 gatgagctta cgccccttgt cagtaatgga aatgatatag gcccggtggt cttttttact
     7681 gaccgtccgt ttgacccaac catttttttc catatttttg atgacaatgg tcatgtttcc
     7741 agatgtcgat aagatactag cgatgaggtc cccaattctc atgggaccct tagcatggag
     7801 aacatccaaa acactaaact gagcaggtgt taaatcaaag tcacggaatg tcgcggaaac
     7861 tctactatca atggtgcgga aggccttacg cataaccacc atacttttga cggcagaatt
     7921 tttgaattct gtcataatgc gatctcctta ttggtaaact tagtggttgc tactgactca
     7981 agccaagggc ttcccagcgc aggaccacct aaattatttt gtcattcttt cctaccaatg
     8041 tgacctaacc gcatcattgt aacactaaaa gcttaagcga gcaagaaatt caacttcaga
     8101 aaaattgccc aaaaatgcct gcatggttga acagggcttg agaggttaac tttgagacca
     8161 tagaattgtc atttatcgct tccttacggg aacccttaag aggcaaaaaa cagctagcac
     8221 aagctaactg ttttgataaa tttatgaggt tacctatttt tttgagaaca gggccttgcc
     8281 caacaataca gttccacaaa gggccacggt cgctagcaag gcctgcttac cagagaactc
     8341 taagcggtag tcgaaatgtt cgtctttgga ctggtcgtcc catttaatca ttaattccat
//
