Select genomic region:
Overview
2.1
2.2
2.3
2.4
2.5
2.6
2.7
2.8
2.9

### Identified secondary metabolite regions using strictness 'relaxed'

NZ_UHFA01000002 (original name was: NZ_UHFA01000002.1)

Region | Type | From | To | Most similar known cluster | Similarity
--- | --- | --- | --- | --- | ---
Region 2.1 | RiPP-like | 28,760 | 40,697 |
Region 2.2 | RiPP-like | 72,854 | 83,748 |
Region 2.3 | RiPP-like | 113,131 | 121,530 |
Region 2.4 | LAP,thiopeptide | 150,534 | 182,468 |
Region 2.5 | NRPS-like,NRPS,T1PKS | 267,699 | 326,520 | xenocoumacin 1 / xenocoumacin II | NRP + Polyketide:Modular type I | 14%
Region 2.6 | RiPP-like | 338,510 | 345,942 |
Region 2.7 | RiPP-like | 1,332,690 | 1,345,724 |
Region 2.8 | T3PKS | 1,362,156 | 1,403,340 | exopolysaccharide | Saccharide | 8%
Region 2.9 | RiPP-like | 1,910,912 | 1,921,220 |

Region | Type | From | To | Most similar known cluster | Similarity
--- | --- | --- | --- | --- | ---
Region 2.1 | RiPP-like | 28,760 | 40,697 |
Region 2.2 | RiPP-like | 72,854 | 83,748 |
Region 2.3 | RiPP-like | 113,131 | 121,530 |
Region 2.4 | LAP,thiopeptide | 150,534 | 182,468 |
Region 2.5 | NRPS-like,NRPS,T1PKS | 267,699 | 326,520 | xenocoumacin 1 / xenocoumacin II | NRP + Polyketide:Modular type I | 14%
Region 2.6 | RiPP-like | 338,510 | 345,942 |
Region 2.7 | RiPP-like | 1,332,690 | 1,345,724 |
Region 2.8 | T3PKS | 1,362,156 | 1,403,340 | exopolysaccharide | Saccharide | 8%
Region 2.9 | RiPP-like | 1,910,912 | 1,921,220 |

No secondary metabolite regions were found in these records:
  NZ_UHFA01000003 (original name was: NZ_UHFA01000003.1)
  NZ_UHFA01000001 (original name was: NZ_UHFA01000001.1)

Compact view
c00002_NZ_UHFA.. - Region 1 - RiPP-like
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 28,760 - 40,697 nt. (total: 11,938 nt) Show pHMM detection rules used
RiPP-like: (strepbact or Antimicrobial14 or Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or Lactococcin or Antimicrobial17 or Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or TIGR03975 or DUF692 or TIGR01193)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
MIBiG comparison
KnownClusterBlast
Pfam domains
TIGRFAM domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | RiPP-like | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000617.1 |  | 0.21 | RiPP | coagulin | Bacillus coagulans
BGC0000619.1 |  | 0.16 | RiPP | gassericin T | Lactobacillus gasseri
BGC0001602.1 |  | 0.16 | RiPP | gassericin-T | Lactobacillus gasseri
BGC0001388.1 |  | 0.16 | RiPP | gassericin E | Lactobacillus gasseri
BGC0000558.1 |  | 0.16 | RiPP | sublancin 168 | Bacillus subtilis subsp. subtilis str. 168
BGC0000624.1 |  | 0.14 | RiPP | salivaricin CRL1328 α peptide, salivaricin CRL1328 β peptide | Lactobacillus salivarius
BGC0000584.1 |  | 0.14 | RiPP | colicin V | Escherichia coli
BGC0000703.1 |  | 0.14 | Saccharide | kanamycin | Streptomyces kanamyceticus
BGC0000294.1 |  | 0.13 | NRP | acinetobactin | Acinetobacter baumannii
BGC0000554.1 |  | 0.13 | RiPP | SRO15-3108 | Streptomyces filamentosus NRRL 15998

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000617.1 |  | 0.54 | RiPP | coagulin | Bacillus coagulans
BGC0000619.1 |  | 0.46 | RiPP | gassericin T | Lactobacillus gasseri
BGC0001602.1 |  | 0.46 | RiPP | gassericin-T | Lactobacillus gasseri
BGC0001388.1 |  | 0.46 | RiPP | gassericin E | Lactobacillus gasseri
BGC0000558.1 |  | 0.46 | RiPP | sublancin 168 | Bacillus subtilis subsp. subtilis str. 168
BGC0000624.1 |  | 0.44 | RiPP | salivaricin CRL1328 α peptide, salivaricin CRL1328 β peptide | Lactobacillus salivarius
BGC0000584.1 |  | 0.44 | RiPP | colicin V | Escherichia coli
BGC0000703.1 |  | 0.43 | Saccharide | kanamycin | Streptomyces kanamyceticus
BGC0000294.1 |  | 0.42 | NRP | acinetobactin | Acinetobacter baumannii
BGC0000554.1 |  | 0.42 | RiPP | SRO15-3108 | Streptomyces filamentosus NRRL 15998

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.

No matches found.

Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
c00002_NZ_UHFA.. - Region 2 - RiPP-like
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 72,854 - 83,748 nt. (total: 10,895 nt) Show pHMM detection rules used
RiPP-like: (strepbact or Antimicrobial14 or Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or Lactococcin or Antimicrobial17 or Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or TIGR03975 or DUF692 or TIGR01193)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
MIBiG comparison
KnownClusterBlast
Pfam domains
TIGRFAM domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | RiPP-like | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000617.1 |  | 0.21 | RiPP | coagulin | Bacillus coagulans
BGC0000619.1 |  | 0.15 | RiPP | gassericin T | Lactobacillus gasseri
BGC0001602.1 |  | 0.15 | RiPP | gassericin-T | Lactobacillus gasseri
BGC0001388.1 |  | 0.15 | RiPP | gassericin E | Lactobacillus gasseri
BGC0000558.1 |  | 0.15 | RiPP | sublancin 168 | Bacillus subtilis subsp. subtilis str. 168
BGC0000584.1 |  | 0.14 | RiPP | colicin V | Escherichia coli
BGC0000624.1 |  | 0.14 | RiPP | salivaricin CRL1328 α peptide, salivaricin CRL1328 β peptide | Lactobacillus salivarius
BGC0000703.1 |  | 0.14 | Saccharide | kanamycin | Streptomyces kanamyceticus
BGC0000768.1 |  | 0.14 | Saccharide | gellan polysaccharide | Sphingomonas elodea ATCC 31461
BGC0000759.1 |  | 0.13 | Saccharide | diutan polysaccharide | Sphingomonas sp. ATCC 53159

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000617.1 |  | 0.54 | RiPP | coagulin | Bacillus coagulans
BGC0000619.1 |  | 0.46 | RiPP | gassericin T | Lactobacillus gasseri
BGC0001602.1 |  | 0.46 | RiPP | gassericin-T | Lactobacillus gasseri
BGC0001388.1 |  | 0.46 | RiPP | gassericin E | Lactobacillus gasseri
BGC0000558.1 |  | 0.46 | RiPP | sublancin 168 | Bacillus subtilis subsp. subtilis str. 168
BGC0000584.1 |  | 0.44 | RiPP | colicin V | Escherichia coli
BGC0000624.1 |  | 0.44 | RiPP | salivaricin CRL1328 α peptide, salivaricin CRL1328 β peptide | Lactobacillus salivarius
BGC0000703.1 |  | 0.43 | Saccharide | kanamycin | Streptomyces kanamyceticus
BGC0000768.1 |  | 0.42 | Saccharide | gellan polysaccharide | Sphingomonas elodea ATCC 31461
BGC0000759.1 |  | 0.42 | Saccharide | diutan polysaccharide | Sphingomonas sp. ATCC 53159

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.

No matches found.

Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
c00002_NZ_UHFA.. - Region 3 - RiPP-like
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 113,131 - 121,530 nt. (total: 8,400 nt) Show pHMM detection rules used
RiPP-like: (strepbact or Antimicrobial14 or Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or Lactococcin or Antimicrobial17 or Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or TIGR03975 or DUF692 or TIGR01193)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
MIBiG comparison
KnownClusterBlast
Pfam domains
TIGRFAM domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | RiPP-like | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000676.1 |  | 0.16 | Terpene | aphidicolin, aphidicolan-16β-ol, 3-deoxyaphidicolin, 17-deoxyaphidicolin | Phoma betae
BGC0000420.1 |  | 0.09 | NRP | histidyltryptophanyldiketopiperazine, dehydrohistidyltryptophanyldiketopiperazine, roquefortine D, roquefortine C, glandicoline A, glandicoline B, meleagrine | Penicillium rubens Wisconsin 54-1255
BGC0001895.1 |  | 0.09 | Polyketide | huanglongmycin A, huanglongmycin B, huanglongmycin C | Streptomyces sp. CB09001
BGC0001538.1 |  | 0.09 | NRP, Polyketide | caboxamycin | Streptomyces sp. NTK 937
BGC0000275.1 |  | 0.09 | Polyketide | tetracenomycin C | Streptomyces glaucescens
BGC0000714.1 |  | 0.07 | Saccharide | sisomicin | Micromonospora inyonensis
BGC0001518.1 |  | 0.07 | Terpene | astellolide A | Aspergillus oryzae RIB40
BGC0000317.1 |  | 0.07 | NRP | cephalosporin C | Acremonium chrysogenum ATCC 11550
BGC0000219.1 |  | 0.07 | Polyketide, Saccharide | elloramycin | Streptomyces olivaceus
BGC0001603.1 |  | 0.06 | Saccharide | gentamicin | Micromonospora echinospora

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000676.1 |  | 0.46 | Terpene | aphidicolin, aphidicolan-16β-ol, 3-deoxyaphidicolin, 17-deoxyaphidicolin | Phoma betae
BGC0000420.1 |  | 0.33 | NRP | histidyltryptophanyldiketopiperazine, dehydrohistidyltryptophanyldiketopiperazine, roquefortine D, roquefortine C, glandicoline A, glandicoline B, meleagrine | Penicillium rubens Wisconsin 54-1255
BGC0001895.1 |  | 0.33 | Polyketide | huanglongmycin A, huanglongmycin B, huanglongmycin C | Streptomyces sp. CB09001
BGC0001538.1 |  | 0.32 | NRP, Polyketide | caboxamycin | Streptomyces sp. NTK 937
BGC0000275.1 |  | 0.32 | Polyketide | tetracenomycin C | Streptomyces glaucescens
BGC0000714.1 |  | 0.29 | Saccharide | sisomicin | Micromonospora inyonensis
BGC0001518.1 |  | 0.28 | Terpene | astellolide A | Aspergillus oryzae RIB40
BGC0000317.1 |  | 0.28 | NRP | cephalosporin C | Acremonium chrysogenum ATCC 11550
BGC0000219.1 |  | 0.27 | Polyketide, Saccharide | elloramycin | Streptomyces olivaceus
BGC0001603.1 |  | 0.27 | Saccharide | gentamicin | Micromonospora echinospora

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.

No matches found.

Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
c00002_NZ_UHFA.. - Region 4 - LAP,thiopeptide
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 150,534 - 182,468 nt. (total: 31,935 nt) Show pHMM detection rules used
LAP: ((((goadsporin_like or PF00881 or TIGR03605) and (YcaO or TIGR03882 or TIGR03604)) or TIGR03603 or TIGR03602) and not cyanobactin_synth)
thiopeptide: ((YcaO or TIGR03882) and ((thio_amide and (PF06968 or PF04055 or PF07366)) or Lant_dehydr_C or Lant_dehydr_N or PF07366 or PF06968 or PF04055) or thiostrepton)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
MIBiG comparison
KnownClusterBlast
Thiopeptides
Pfam domains
TIGRFAM domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | LAP | thiopeptide | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | --- | ---
BGC0001174.1 |  |  | 0.52 | RiPP | corynazolicin | Corynebacterium urealyticum DSM 7111
BGC0002013.1 |  |  | 0.45 | RiPP | curacozole | Streptomyces curacoi
BGC0000606.1 |  |  | 0.41 | RiPP | lactazole | Streptomyces lactacystinaeus
BGC0001687.1 |  |  | 0.40 | Other | N-tetradecanoyl tyrosine | uncultured bacterium CSL12
BGC0001618.1 |  |  | 0.38 | RiPP | hyicin 3682 | Staphylococcus hyicus
BGC0000541.1 |  |  | 0.37 | RiPP | paenicidin A | Paenibacillus polymyxa
BGC0000542.1 |  |  | 0.37 | RiPP | paenicidin B | Paenibacillus terrae
BGC0001146.1 |  |  | 0.36 | RiPP | cyclothiazomycin C | Streptomyces sp. NRRL WC-3908
BGC0000607.1 |  |  | 0.36 | RiPP | micrococcin P1 | Macrococcus caseolyticus
BGC0000603.1 |  |  | 0.35 | RiPP | cyclothiazomycin | Streptomyces hygroscopicus

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001174.1 |  | 0.59 | RiPP | corynazolicin | Corynebacterium urealyticum DSM 7111
BGC0002013.1 |  | 0.56 | RiPP | curacozole | Streptomyces curacoi
BGC0000606.1 |  | 0.53 | RiPP | lactazole | Streptomyces lactacystinaeus
BGC0001687.1 |  | 0.52 | Other | N-tetradecanoyl tyrosine | uncultured bacterium CSL12
BGC0001618.1 |  | 0.51 | RiPP | hyicin 3682 | Staphylococcus hyicus
BGC0000541.1 |  | 0.50 | RiPP | paenicidin A | Paenibacillus polymyxa
BGC0000542.1 |  | 0.50 | RiPP | paenicidin B | Paenibacillus terrae
BGC0001146.1 |  | 0.50 | RiPP | cyclothiazomycin C | Streptomyces sp. NRRL WC-3908
BGC0000607.1 |  | 0.49 | RiPP | micrococcin P1 | Macrococcus caseolyticus
BGC0000603.1 |  | 0.49 | RiPP | cyclothiazomycin | Streptomyces hygroscopicus

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.

No matches found.

Thiopeptide predictions
Lists the possible core peptides for each biosynthetic enzyme, including the predicted class. Each core peptide shows the leader and core peptide sequences, separated by a dash. Predicted tail sequences are also shown.
No core peptides found.
Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
Thiopeptides
Core peptide predictions
Lists the possible core peptides in the region. Each core peptide lists its possible molecular weights and the scores for cleavage site prediction and RODEO. If relevant, other features, such as macrocycle and amidation, will also be listed.
No core peptides found.
c00002_NZ_UHFA.. - Region 5 - NRPS,NRPS-like,T1PKS
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 267,699 - 326,520 nt. (total: 58,822 nt) Show pHMM detection rules used
NRPS-like: cds((PP-binding or NAD_binding_4) and (AMP-binding or A-OX))
NRPS: cds(Condensation and (AMP-binding or A-OX))
T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
NRPS/PKS domains
MIBiG comparison
KnownClusterBlast
NRPS/PKS modules
Pfam domains
TIGRFAM domains
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
A glossary is available here.
Selected features only
Show module domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | NRPS-like | NRPS | T1PKS | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | --- | --- | ---
BGC0001778.1 |  |  |  | 0.90 | Other | showdomycin | Streptomyces showdoensis
BGC0000258.1 |  |  |  | 0.83 | Polyketide | prodigiosin | Serratia sp.
BGC0001524.1 |  |  |  | 0.82 | NRP, Polyketide | barnesin A | Sulfurospirillum barnesii SES-3
BGC0000436.1 |  |  |  | 0.80 | NRP | syringolin A | Rhizobium sp. AP16
BGC0000259.1 |  |  |  | 0.78 | Polyketide | prodigiosin | Serratia marcescens
BGC0000044.1 |  |  |  | 0.78 | Polyketide | dawenol | Stigmatella aurantiaca DW4/3-1
BGC0001585.1 |  |  |  | 0.77 | Alkaloid | melinacidin IV | Escovopsis weberi
BGC0001123.1 |  |  |  | 0.75 | NRP | aspirochlorine | Aspergillus oryzae RIB40
BGC0000383.1 |  |  |  | 0.75 | NRP, Polyketide | luminmycin A | Photorhabdus laumondii subsp. laumondii TTO1
BGC0001918.1 |  |  |  | 0.75 | NRP, Polyketide | JBIR-06 | Streptomyces sp.

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001778.1 |  | 0.64 | Other | showdomycin | Streptomyces showdoensis
BGC0000258.1 |  | 0.61 | Polyketide | prodigiosin | Serratia sp.
BGC0001524.1 |  | 0.61 | NRP, Polyketide | barnesin A | Sulfurospirillum barnesii SES-3
BGC0000436.1 |  | 0.60 | NRP | syringolin A | Rhizobium sp. AP16
BGC0000259.1 |  | 0.60 | Polyketide | prodigiosin | Serratia marcescens
BGC0000044.1 |  | 0.60 | Polyketide | dawenol | Stigmatella aurantiaca DW4/3-1
BGC0001585.1 |  | 0.59 | Alkaloid | melinacidin IV | Escovopsis weberi
BGC0001123.1 |  | 0.59 | NRP | aspirochlorine | Aspergillus oryzae RIB40
BGC0000383.1 |  | 0.58 | NRP, Polyketide | luminmycin A | Photorhabdus laumondii subsp. laumondii TTO1
BGC0001918.1 |  | 0.58 | NRP, Polyketide | JBIR-06 | Streptomyces sp.

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.
Module view
Shows module structures for each candidate in NRPS- and PKS regions. Genes are shown in predicted order, and are only present when containing at least one complete module. A domain glossary is available here.
Legend
Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
NRPS/PKS products
NRPS/PKS monomers
Predicted core structure(s)
Shows estimated product structure and polymer for each candidate cluster in the region. To show the product, click on the expander or the candidate cluster feature drawn in the overview.
For candidate cluster 5, location 267698 - 326520:
Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:
  (X - mal - gly - ile) + (X)

Direct lookup in NORINE database: strict or relaxed

For candidate cluster 6, location 267698 - 309584:
Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:
  (X - mal - gly - ile) + (X)

Direct lookup in NORINE database: strict or relaxed

For candidate cluster 7, location 270350 - 326520:
Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:
  (X - mal - gly - ile) + (X)

Direct lookup in NORINE database: strict or relaxed
Link to NORINE database query form
NRPS/PKS monomer predictions
Shows the predicted monomers for each adynelation domain and acyltransferase within genes. Each gene prediction can be expanded to view detailed predictions of each domain. Each prediction can be expanded to view the predictions by tool (and, for some tools, further expanded for extra details).

ctg2_253: mal
  PKS_AT (7..292): mal
  ATSignature: Malonyl-CoA
  Top 3 matches:
    Malonyl-CoA: 66.7%
  minowa: Malonyl-CoA
  Prediction, score:
    Malonyl-CoA: 34.8
    Methoxymalonyl-CoA: 31.2
    Methylmalonyl-CoA: 23.7
    Ethylmalonyl-CoA: 11.9
    2-Methylbutyryl-CoA: 11.5
    fatty_acid: 10.2
    inactive: 10.1
    Isobutyryl-CoA: 5.5
    trans-1,2-CPDA: 0.0
    Propionyl-CoA: 0.0
    CHC-CoA: 0.0
    Benzoyl-CoA: 0.0
    Acetyl-CoA: 0.0
    3-Methylbutyryl-CoA: 0.0
ctg2_267: X
  Search NORINE for peptide: strict or relaxed
  AMP-binding (35..456): X
  NRPSPredictor2: (unknown)
  SVM prediction details:
    NOTE: outside applicability domain
    Predicted physicochemical class:
      N/A
    Large clusters prediction:
      N/A
    Small clusters prediction:
      N/A
    Single AA prediction:
      N/A
  Stachelhaus prediction details:
    Stachelhaus sequence:
      gAFcyGgVaK
    Nearest Stachelhaus code:
      val
    Stachelhaus code match:
      50% (weak)
ctg2_268: X - mal - gly - ile
  Search NORINE for peptide: strict or relaxed
  AMP-binding (458..867): X
  NRPSPredictor2: hydrophobic-aliphatic
  SVM prediction details:
    Predicted physicochemical class:
      hydrophobic-aliphatic
    Large clusters prediction:
      N/A
    Small clusters prediction:
      N/A
    Single AA prediction:
      N/A
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DItnfGVmWK
    Nearest Stachelhaus code:
      gly
    Stachelhaus code match:
      60% (weak)
  PKS_AT (1585..1882): mal
  ATSignature: Malonyl-CoA
  Top 3 matches:
    Malonyl-CoA: 83.3%
    inactive: 79.2%
    Methylmalonyl-CoA: 54.2%
  minowa: Malonyl-CoA
  Prediction, score:
    Malonyl-CoA: 100.0
    inactive: 60.0
    Methoxymalonyl-CoA: 41.1
    Methylmalonyl-CoA: 25.6
    Isobutyryl-CoA: 22.7
    Propionyl-CoA: 16.4
    Benzoyl-CoA: 10.6
    trans-1,2-CPDA: 0.0
    fatty_acid: 0.0
    Ethylmalonyl-CoA: 0.0
    CHC-CoA: 0.0
    Acetyl-CoA: 0.0
    3-Methylbutyryl-CoA: 0.0
    2-Methylbutyryl-CoA: 0.0
  AMP-binding (2518..2916): gly
  NRPSPredictor2: gly
  SVM prediction details:
    Predicted physicochemical class:
      hydrophobic-aliphatic
    Large clusters prediction:
      gly, ala, val, leu, ile, abu, iva
    Small clusters prediction:
      gly, ala
    Single AA prediction:
      gly
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DIylLGLIWK
    Nearest Stachelhaus code:
      gly
    Stachelhaus code match:
      80% (moderate)
  AMP-binding (4375..4774): ile
  NRPSPredictor2: ile
  SVM prediction details:
    Predicted physicochemical class:
      hydrophobic-aliphatic
    Large clusters prediction:
      gly, ala, val, leu, ile, abu, iva
    Small clusters prediction:
      val, leu, ile, abu, iva
    Single AA prediction:
      N/A
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DAFFLGVvFK
    Nearest Stachelhaus code:
      ile
    Stachelhaus code match:
      90% (moderate)

c00002_NZ_UHFA.. - Region 6 - RiPP-like
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 338,510 - 345,942 nt. (total: 7,433 nt) Show pHMM detection rules used
RiPP-like: (strepbact or Antimicrobial14 or Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or Lactococcin or Antimicrobial17 or Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or TIGR03975 or DUF692 or TIGR01193)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
MIBiG comparison
KnownClusterBlast
Pfam domains
TIGRFAM domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

No matches found.

No matches found.

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.

No matches found.

Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
c00002_NZ_UHFA.. - Region 7 - RiPP-like
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 1,332,690 - 1,345,724 nt. (total: 13,035 nt) Show pHMM detection rules used
RiPP-like: (strepbact or Antimicrobial14 or Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or Lactococcin or Antimicrobial17 or Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or TIGR03975 or DUF692 or TIGR01193)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
MIBiG comparison
KnownClusterBlast
Pfam domains
TIGRFAM domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | RiPP-like | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000617.1 |  | 0.39 | RiPP | coagulin | Bacillus coagulans
BGC0000619.1 |  | 0.34 | RiPP | gassericin T | Lactobacillus gasseri
BGC0001602.1 |  | 0.34 | RiPP | gassericin-T | Lactobacillus gasseri
BGC0001388.1 |  | 0.34 | RiPP | gassericin E | Lactobacillus gasseri
BGC0000624.1 |  | 0.29 | RiPP | salivaricin CRL1328 α peptide, salivaricin CRL1328 β peptide | Lactobacillus salivarius
BGC0000558.1 |  | 0.16 | RiPP | sublancin 168 | Bacillus subtilis subsp. subtilis str. 168
BGC0001928.1 |  | 0.14 | Other | (2R,3S,4S)-5-fluoro-2,3,4-trihydroxypentanoic acid | Streptomyces sp. MA37
BGC0000584.1 |  | 0.14 | RiPP | colicin V | Escherichia coli
BGC0000703.1 |  | 0.14 | Saccharide | kanamycin | Streptomyces kanamyceticus
BGC0001765.1 |  | 0.14 | Saccharide | salecan | Agrobacterium tumefaciens

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000617.1 |  | 0.71 | RiPP | coagulin | Bacillus coagulans
BGC0000619.1 |  | 0.67 | RiPP | gassericin T | Lactobacillus gasseri
BGC0001602.1 |  | 0.67 | RiPP | gassericin-T | Lactobacillus gasseri
BGC0001388.1 |  | 0.67 | RiPP | gassericin E | Lactobacillus gasseri
BGC0000624.1 |  | 0.63 | RiPP | salivaricin CRL1328 α peptide, salivaricin CRL1328 β peptide | Lactobacillus salivarius
BGC0000558.1 |  | 0.46 | RiPP | sublancin 168 | Bacillus subtilis subsp. subtilis str. 168
BGC0001928.1 |  | 0.44 | Other | (2R,3S,4S)-5-fluoro-2,3,4-trihydroxypentanoic acid | Streptomyces sp. MA37
BGC0000584.1 |  | 0.43 | RiPP | colicin V | Escherichia coli
BGC0000703.1 |  | 0.43 | Saccharide | kanamycin | Streptomyces kanamyceticus
BGC0001765.1 |  | 0.43 | Saccharide | salecan | Agrobacterium tumefaciens

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.

No matches found.

Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
c00002_NZ_UHFA.. - Region 8 - T3PKS
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 1,362,156 - 1,403,340 nt. (total: 41,185 nt) Show pHMM detection rules used
T3PKS: (Chal_sti_synt_C or Chal_sti_synt_N)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
NRPS/PKS domains
MIBiG comparison
KnownClusterBlast
Pfam domains
TIGRFAM domains
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
A glossary is available here.
Selected features only
Show module domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | T3PKS | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000286.1 |  | 0.22 | Polyketide | viguiepinol | Streptomyces sp. KO-3988
BGC0001412.1 |  | 0.20 | Saccharide | polysaccharide C | Bacteroides fragilis
BGC0000770.1 |  | 0.19 | Saccharide | lipo-oligosaccharide | Campylobacter jejuni
BGC0000758.1 |  | 0.18 | Saccharide | capsular polysaccharide | Staphylococcus aureus
BGC0000730.1 |  | 0.18 | Saccharide | capsular polysaccharide | Klebsiella pneumoniae
BGC0000731.1 |  | 0.18 | Saccharide | capsular polysaccharide | Klebsiella pneumoniae
BGC0001848.1 |  | 0.18 | Other | diazaquinomycin H, diazaquinomycin J | Micromonospora sp. B006
BGC0000764.1 |  | 0.18 | Saccharide | exopolysaccharide | Lactococcus lactis
BGC0000748.1 |  | 0.18 | Saccharide | capsular polysaccharide | Streptococcus agalactiae
BGC0000740.1 |  | 0.18 | Saccharide | capsular polysaccharide | Streptococcus agalactiae

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000286.1 |  | 0.56 | Polyketide | viguiepinol | Streptomyces sp. KO-3988
BGC0001412.1 |  | 0.52 | Saccharide | polysaccharide C | Bacteroides fragilis
BGC0000770.1 |  | 0.51 | Saccharide | lipo-oligosaccharide | Campylobacter jejuni
BGC0000758.1 |  | 0.50 | Saccharide | capsular polysaccharide | Staphylococcus aureus
BGC0000730.1 |  | 0.50 | Saccharide | capsular polysaccharide | Klebsiella pneumoniae
BGC0000731.1 |  | 0.50 | Saccharide | capsular polysaccharide | Klebsiella pneumoniae
BGC0001848.1 |  | 0.50 | Other | diazaquinomycin H, diazaquinomycin J | Micromonospora sp. B006
BGC0000764.1 |  | 0.49 | Saccharide | exopolysaccharide | Lactococcus lactis
BGC0000748.1 |  | 0.49 | Saccharide | capsular polysaccharide | Streptococcus agalactiae
BGC0000740.1 |  | 0.49 | Saccharide | capsular polysaccharide | Streptococcus agalactiae

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.
Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
c00002_NZ_UHFA.. - Region 9 - RiPP-like
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 1,910,912 - 1,921,220 nt. (total: 10,309 nt) Show pHMM detection rules used
RiPP-like: (strepbact or Antimicrobial14 or Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or Lactococcin or Antimicrobial17 or Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or TIGR03975 or DUF692 or TIGR01193)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
MIBiG comparison
KnownClusterBlast
Pfam domains
TIGRFAM domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | RiPP-like | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000344.1 |  | 0.03 | NRP | entolysin | Pseudomonas entomophila L48

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000344.1 |  | 0.15 | NRP | entolysin | Pseudomonas entomophila L48

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.

No matches found.

Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names