LOCUS       NZ_LS483338.1          22784 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  NZ_LS483338.1 Streptococcus pyogenes strain NCTC12064 chromosome 1,
            complete sequence.
ACCESSION   NZ_LS483338
VERSION     NZ_LS483338.1
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 6.1.1
            Run date     :: 2024-03-14 12:58:57
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 1289899
            Orig. end    :: 1312683
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..22784
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[1299899:1302683](-)"
                     /cutoff="20000"
                     /detection_rule="cds(LANC_like and DUF4135)"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-ii"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..12784)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="cds(LANC_like and DUF4135)"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-ii"
                     /protocluster_number="1"
     cand_cluster    1..22784
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="cds(LANC_like and DUF4135)"
                     /kind="single"
                     /product="lanthipeptide-class-ii"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..22784
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="lanthipeptide-class-ii"
                     /region_number="3"
                     /rules="cds(LANC_like and DUF4135)"
                     /tool="antismash"
     CDS             complement(670..2220)
                     /locus_tag="ctg1_1221"
                     /transl_table=11
                     /translation="MGLFDRLFGKKETPKVAEEKLEENLLTETTQKEELSEKANEQDKI
                     EAVQQEDVSSEGAGSVENGPEAASVNALVEEETGDNSNHPSEDTNEFAADKTDLKVSEL
                     SQSTASEPKDLVDQPVVEQFPTKQAQADASNDSANEEAVDTSKEQSSSQQVMEDYYRRK
                     AALEKSLQEKAAATVPVMPEEVPQENQASTSAEASQNKATHDTIPETDQEKYKRSLKKT
                     RTGFSARLNSFFANFRRVDEEFFEDLEEMLILSDVGVHVATTLTEELRYEAKLENAKKP
                     DALKRVIVEKLVDIYEKDGRYNEAINYQDGLTVMLFVGVNGVGKTTSIGKLAYRYKQEG
                     KKVMLVAADTFRAGAVAQLVEWGRRVDVPVITGPEKADPASVVFDGMEKAVAKGVDILL
                     IDTAGRLQNKENLMAELEKMGRIIKRVLPDAPHETLLALDASTGQNALSQAKEFSKITP
                     LTGLILTKIDGTAKGGVVLAIRQELDIPVKFIGFGEKVDDIGEFHSEDFMKGLLEGIL"
     PFAM_domain     complement(685..1284)
                     /aSDomain="SRP54"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00448.24"
                     /description="SRP54-type protein, GTPase domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_1221_0075"
                     /evalue="5.70E-76"
                     /label="ctg1_1221"
                     /locus_tag="ctg1_1221"
                     /protein_end="512"
                     /protein_start="312"
                     /score="254.6"
                     /tool="antismash"
                     /translation="TVMLFVGVNGVGKTTSIGKLAYRYKQEGKKVMLVAADTFRAGAVA
                     QLVEWGRRVDVPVITGPEKADPASVVFDGMEKAVAKGVDILLIDTAGRLQNKENLMAEL
                     EKMGRIIKRVLPDAPHETLLALDASTGQNALSQAKEFSKITPLTGLILTKIDGTAKGGV
                     VLAIRQELDIPVKFIGFGEKVDDIGEFHSEDFMKGLL"
     aSDomain        complement(685..1503)
                     /aSDomain="TIGR00064"
                     /aSTool="tigrfam"
                     /description="ftsY: signal recognition particle-docking
                     protein FtsY"
                     /detection="hmmscan"
                     /domain_id="TIGRFam_ctg1_1221_0029"
                     /evalue="5.40E-107"
                     /identifier="TIGR00064"
                     /label="ctg1_1221"
                     /locus_tag="ctg1_1221"
                     /protein_end="512"
                     /protein_start="239"
                     /score="355.1"
                     /tool="antismash"
                     /translation="VDEEFFEDLEEMLILSDVGVHVATTLTEELRYEAKLENAKKPDAL
                     KRVIVEKLVDIYEKDGRYNEAINYQDGLTVMLFVGVNGVGKTTSIGKLAYRYKQEGKKV
                     MLVAADTFRAGAVAQLVEWGRRVDVPVITGPEKADPASVVFDGMEKAVAKGVDILLIDT
                     AGRLQNKENLMAELEKMGRIIKRVLPDAPHETLLALDASTGQNALSQAKEFSKITPLTG
                     LILTKIDGTAKGGVVLAIRQELDIPVKFIGFGEKVDDIGEFHSEDFMKGLL"
     PFAM_domain     complement(1345..1542)
                     /aSDomain="SRP54_N"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF02881.21"
                     /description="SRP54-type protein, helical bundle domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_1221_0074"
                     /evalue="1.30E-11"
                     /label="ctg1_1221"
                     /locus_tag="ctg1_1221"
                     /protein_end="292"
                     /protein_start="226"
                     /score="44.6"
                     /tool="antismash"
                     /translation="SARLNSFFANFRRVDEEFFEDLEEMLILSDVGVHVATTLTEELRY
                     EAKLENAKKPDALKRVIVEKL"
     CDS             complement(2220..3044)
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1179:hydrolase (Score: 160.5; E-value: 9.9e-49)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg1_1222"
                     /transl_table=11
                     /translation="MNIRILALDLDGTLYNTEKIVTDANKKALAAAREKGVKVVITTGR
                     PLKAIGNLLEELDLLDHDDYSITFNGGLVQRNTGEVLDKSSLSFDQICQIQQALEAVGL
                     PTDIISGGDVYSIPSKDGRHSQYHLANPLLTFIEVTSVAELPKDITYNKIVTVTDPDFL
                     DQQIIKLSPSLFEDFEAFKSRDIIFEIMPKGIDKAFGLNLLCQHLGLEARHVMAMGDEA
                     NDFAMLEWAGLGVAMANGVSGAKAVADAVTTLTNDESGVAEAVKTFILEEES"
     PFAM_domain     complement(2253..3029)
                     /aSDomain="Hydrolase_3"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF08282.14"
                     /description="haloacid dehalogenase-like hydrolase"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_1222_0076"
                     /evalue="8.10E-59"
                     /label="ctg1_1222"
                     /locus_tag="ctg1_1222"
                     /protein_end="264"
                     /protein_start="5"
                     /score="199.5"
                     /tool="antismash"
                     /translation="LALDLDGTLYNTEKIVTDANKKALAAAREKGVKVVITTGRPLKAI
                     GNLLEELDLLDHDDYSITFNGGLVQRNTGEVLDKSSLSFDQICQIQQALEAVGLPTDII
                     SGGDVYSIPSKDGRHSQYHLANPLLTFIEVTSVAELPKDITYNKIVTVTDPDFLDQQII
                     KLSPSLFEDFEAFKSRDIIFEIMPKGIDKAFGLNLLCQHLGLEARHVMAMGDEANDFAM
                     LEWAGLGVAMANGVSGAKAVADAVTTLTNDESGVAEA"
     aSDomain        complement(2253..3032)
                     /aSDomain="TIGR00099"
                     /aSTool="tigrfam"
                     /description="Cof-subfamily: Cof-like hydrolase"
                     /detection="hmmscan"
                     /domain_id="TIGRFam_ctg1_1222_0030"
                     /evalue="7.00E-55"
                     /identifier="TIGR00099"
                     /label="ctg1_1222"
                     /locus_tag="ctg1_1222"
                     /protein_end="264"
                     /protein_start="4"
                     /score="184.3"
                     /tool="antismash"
                     /translation="ILALDLDGTLYNTEKIVTDANKKALAAAREKGVKVVITTGRPLKA
                     IGNLLEELDLLDHDDYSITFNGGLVQRNTGEVLDKSSLSFDQICQIQQALEAVGLPTDI
                     ISGGDVYSIPSKDGRHSQYHLANPLLTFIEVTSVAELPKDITYNKIVTVTDPDFLDQQI
                     IKLSPSLFEDFEAFKSRDIIFEIMPKGIDKAFGLNLLCQHLGLEARHVMAMGDEANDFA
                     MLEWAGLGVAMANGVSGAKAVADAVTTLTNDESGVAEA"
     aSDomain        complement(2334..3032)
                     /aSDomain="TIGR01484"
                     /aSTool="tigrfam"
                     /description="HAD-SF-IIB: HAD hydrolase, family IIB"
                     /detection="hmmscan"
                     /domain_id="TIGRFam_ctg1_1222_0031"
                     /evalue="1.40E-27"
                     /identifier="TIGR01484"
                     /label="ctg1_1222"
                     /locus_tag="ctg1_1222"
                     /protein_end="237"
                     /protein_start="4"
                     /score="95.1"
                     /tool="antismash"
                     /translation="ILALDLDGTLYNTEKIVTDANKKALAAAREKGVKVVITTGRPLKA
                     IGNLLEELDLLDHDDYSITFNGGLVQRNTGEVLDKSSLSFDQICQIQQALEAVGLPTDI
                     ISGGDVYSIPSKDGRHSQYHLANPLLTFIEVTSVAELPKDITYNKIVTVTDPDFLDQQI
                     IKLSPSLFEDFEAFKSRDIIFEIMPKGIDKAFGLNLLCQHLGLEARHVMAMGDEANDFA
                     MLEWAGLGVAM"
     CDS             complement(3048..3845)
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1179:hydrolase (Score: 144.7; E-value: 6.2e-44)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg1_1223"
                     /transl_table=11
                     /translation="MIKLIATDMDGTFLAEDGTYNQEQLAALLPKLAEKGILFAVSSGR
                     SLLAIDQLFEPFLDQIAVIAENGSVVQYHGEILFADMMTKEQYTEVAKKVLANPHYVET
                     GMVFSGQKAAYILKGASEEYIQKTKHYYANVKVINGFEDMENDAIFKVSTNFTGHTVLE
                     GSDWLNQALPYATAVTTGFDSIDIILKEVNKGFGMEHLCQALGIKKAETIAFGDNFNDY
                     QMLEFAGRAIATENARPEIKVISDQVIGHCNDGAVLTYLKGLV"
     PFAM_domain     complement(3063..3833)
                     /aSDomain="Hydrolase_3"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF08282.14"
                     /description="haloacid dehalogenase-like hydrolase"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_1223_0077"
                     /evalue="1.00E-49"
                     /label="ctg1_1223"
                     /locus_tag="ctg1_1223"
                     /protein_end="261"
                     /protein_start="4"
                     /score="169.7"
                     /tool="antismash"
                     /translation="IATDMDGTFLAEDGTYNQEQLAALLPKLAEKGILFAVSSGRSLLA
                     IDQLFEPFLDQIAVIAENGSVVQYHGEILFADMMTKEQYTEVAKKVLANPHYVETGMVF
                     SGQKAAYILKGASEEYIQKTKHYYANVKVINGFEDMENDAIFKVSTNFTGHTVLEGSDW
                     LNQALPYATAVTTGFDSIDIILKEVNKGFGMEHLCQALGIKKAETIAFGDNFNDYQMLE
                     FAGRAIATENARPEIKVISDQVIGHCNDGAVLTYL"
     aSDomain        complement(3063..3836)
                     /aSDomain="TIGR00099"
                     /aSTool="tigrfam"
                     /description="Cof-subfamily: Cof-like hydrolase"
                     /detection="hmmscan"
                     /domain_id="TIGRFam_ctg1_1223_0032"
                     /evalue="3.60E-45"
                     /identifier="TIGR00099"
                     /label="ctg1_1223"
                     /locus_tag="ctg1_1223"
                     /protein_end="261"
                     /protein_start="3"
                     /score="152.5"
                     /tool="antismash"
                     /translation="LIATDMDGTFLAEDGTYNQEQLAALLPKLAEKGILFAVSSGRSLL
                     AIDQLFEPFLDQIAVIAENGSVVQYHGEILFADMMTKEQYTEVAKKVLANPHYVETGMV
                     FSGQKAAYILKGASEEYIQKTKHYYANVKVINGFEDMENDAIFKVSTNFTGHTVLEGSD
                     WLNQALPYATAVTTGFDSIDIILKEVNKGFGMEHLCQALGIKKAETIAFGDNFNDYQML
                     EFAGRAIATENARPEIKVISDQVIGHCNDGAVLTYL"
     aSDomain        complement(3147..3836)
                     /aSDomain="TIGR01484"
                     /aSTool="tigrfam"
                     /description="HAD-SF-IIB: HAD hydrolase, family IIB"
                     /detection="hmmscan"
                     /domain_id="TIGRFam_ctg1_1223_0033"
                     /evalue="1.10E-27"
                     /identifier="TIGR01484"
                     /label="ctg1_1223"
                     /locus_tag="ctg1_1223"
                     /protein_end="233"
                     /protein_start="3"
                     /score="95.5"
                     /tool="antismash"
                     /translation="LIATDMDGTFLAEDGTYNQEQLAALLPKLAEKGILFAVSSGRSLL
                     AIDQLFEPFLDQIAVIAENGSVVQYHGEILFADMMTKEQYTEVAKKVLANPHYVETGMV
                     FSGQKAAYILKGASEEYIQKTKHYYANVKVINGFEDMENDAIFKVSTNFTGHTVLEGSD
                     WLNQALPYATAVTTGFDSIDIILKEVNKGFGMEHLCQALGIKKAETIAFGDNFNDYQML
                     EFAGRAIA"
     CDS             4150..4425
                     /gene_functions="other (smcogs) SMCOG1164:transposase
                     IS3/IS911 family protein (Score: 67.1; E-value: 1.8e-20)"
                     /gene_kind="other"
                     /locus_tag="ctg1_1224"
                     /transl_table=11
                     /translation="MSTVKRYDEEFKQSLVNLYQTGKTQSELCKDYGVSASALAKWIKQ
                     YSQVKLEDNSVLTAKQIQELQKRNAQLEEENLILKKASAIFMQNLK"
     PFAM_domain     4156..4377
                     /aSDomain="HTH_Tnp_1"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF01527.22"
                     /description="Transposase"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_1224_0078"
                     /evalue="3.40E-14"
                     /label="ctg1_1224"
                     /locus_tag="ctg1_1224"
                     /protein_end="76"
                     /protein_start="2"
                     /score="53.0"
                     /tool="antismash"
                     /translation="TVKRYDEEFKQSLVNLYQTGKTQSELCKDYGVSASALAKWIKQYS
                     QVKLEDNSVLTAKQIQELQKRNAQLEEEN"
     CDS             4545..5276
                     /gene_functions="other (smcogs) SMCOG1026:transposase
                     (Score: 251.3; E-value: 1.6e-76)"
                     /gene_kind="other"
                     /locus_tag="ctg1_1225"
                     /transl_table=11
                     /translation="LDNQIYKKQILEIYTKANKRLGVKSIKVILQRDYDTKISEGRIYR
                     LMKNMALPKMATVKPKTALKRTQKTYPQNLLNQKFNPDKPNQVWSTDFTYISIGYKKYV
                     YLCAILDLYSRKCIAWKLSHHMDAKLACDTLELALNKRKIEGALLFHSDQGSQFKAREL
                     RKIIDDNTIMHSFSKPGYPYDNAVTEAFFKYLKHRQINRKKYQNIKQVQLDCFEYIENF
                     YNNYNPHTANLGLNPNQKEEN"
     PFAM_domain     4563..4700
                     /aSDomain="HTH_21"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF13276.8"
                     /description="HTH-like domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_1225_0079"
                     /evalue="1.10E-08"
                     /label="ctg1_1225"
                     /locus_tag="ctg1_1225"
                     /protein_end="52"
                     /protein_start="6"
                     /score="35.1"
                     /tool="antismash"
                     /translation="KKQILEIYTKANKRLGVKSIKVILQRDYDTKISEGRIYRLMKNMA
                     L"
     PFAM_domain     4791..5090
                     /aSDomain="rve"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00665.28"
                     /description="Integrase core domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_1225_0080"
                     /evalue="7.20E-26"
                     /label="ctg1_1225"
                     /locus_tag="ctg1_1225"
                     /protein_end="182"
                     /protein_start="82"
                     /score="90.5"
                     /tool="antismash"
                     /translation="DKPNQVWSTDFTYISIGYKKYVYLCAILDLYSRKCIAWKLSHHMD
                     AKLACDTLELALNKRKIEGALLFHSDQGSQFKARELRKIIDDNTIMHSFSKPGYP"
     PFAM_domain     5109..5225
                     /aSDomain="rve_2"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF13333.8"
                     /description="Integrase core domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_1225_0081"
                     /evalue="8.40E-05"
                     /label="ctg1_1225"
                     /locus_tag="ctg1_1225"
                     /protein_end="227"
                     /protein_start="188"
                     /score="22.8"
                     /tool="antismash"
                     /translation="EAFFKYLKHRQINRKKYQNIKQVQLDCFEYIENFYNNYN"
     CDS             complement(5390..6127)
                     /locus_tag="ctg1_1226"
                     /transl_table=11
                     /translation="MNDYFKAEWLKTRKGAILAVGIIFLVLSSFIGLANFFLNYEVLIE
                     EQMSRVLWGQLTFYNSQLLFPAMLAIFSGMIILPEFERKTFEMLRANQVSVKKMLLSKF
                     LLALLLITVIQVLLFVIYLVTLKLSQIPFVAKDLLLFLRATVLSVIGSSSVVMIHSYIM
                     AKTKNFSKSVGIAAIGSFCGFIFIMLGGVINQFFPYSQPMIGIRSRALVDMSISEFVIF
                     IVVNALYSFIFFKLTLRTLEKNG"
     PFAM_domain     complement(5579..6115)
                     /aSDomain="ABC2_membrane_4"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF12730.9"
                     /description="ABC-2 family transporter protein"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_1226_0082"
                     /evalue="1.50E-13"
                     /label="ctg1_1226"
                     /locus_tag="ctg1_1226"
                     /protein_end="183"
                     /protein_start="4"
                     /score="51.2"
                     /tool="antismash"
                     /translation="FKAEWLKTRKGAILAVGIIFLVLSSFIGLANFFLNYEVLIEEQMS
                     RVLWGQLTFYNSQLLFPAMLAIFSGMIILPEFERKTFEMLRANQVSVKKMLLSKFLLAL
                     LLITVIQVLLFVIYLVTLKLSQIPFVAKDLLLFLRATVLSVIGSSSVVMIHSYIMAKTK
                     NFSKSVGIAAIGSFCG"
     CDS             complement(6120..6884)
                     /locus_tag="ctg1_1227"
                     /transl_table=11
                     /translation="MIKAIQIELLKSKRTKSFMISFIMMLVAVTWSLLAASRSIDIPKL
                     RTIGLFFNNLQANSIFLPIATCLFVSRIVGNEKEGSTFKLQEANNTNLIIIFTRKLIFT
                     NSVFLLLNIFQVLIVYLNVLRYDIQVPIWTLILQVVGLTMSSFTLITLFLYLSIILEKQ
                     GILLGIGFLSGFFGMITSQTLKWINLIFPFGGSSFLALYRIKILNSSDSLDYIFSWDKS
                     VPLNYTLYLIYCVMIYSVVKYLLKKKKGDNNE"
     CDS             complement(6886..7794)
                     /gene_functions="transport (smcogs) SMCOG1000:ABC
                     transporter ATP-binding protein (Score: 170.3; E-value:
                     9.2e-52)"
                     /gene_kind="transport"
                     /locus_tag="ctg1_1228"
                     /transl_table=11
                     /translation="MKNAIELRKLSKVYQDITTVDLEKITVREGEIYGFLGPNGAGKTT
                     TMKMILSLVSPTLGEILINGEDIKGNHAYLSVIGSMIEEPSYYPNLTGYENLLVFQKMV
                     GFDESNIWPTLALVGLAEENNRKKLVKAYSLGMKQRLALAFALVKKPKILLLDEPTNGL
                     DPAGIHEIRELIVKLAKEKGLTVFISSHILSEIEHIADRVGIINHGRLVYEGEIEAIKS
                     NTWIEIGGDFSQNNIVQSLINYGQVEVLGASASHVKFKNIDNDKLADVVTYLIENDYRI
                     FRVVRESENLEDIFLSLTKEV"
     PFAM_domain     complement(7312..7722)
                     /aSDomain="ABC_tran"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00005.29"
                     /description="ABC transporter"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_1228_0083"
                     /evalue="4.80E-28"
                     /label="ctg1_1228"
                     /locus_tag="ctg1_1228"
                     /protein_end="161"
                     /protein_start="24"
                     /score="98.5"
                     /tool="antismash"
                     /translation="ITVREGEIYGFLGPNGAGKTTTMKMILSLVSPTLGEILINGEDIK
                     GNHAYLSVIGSMIEEPSYYPNLTGYENLLVFQKMVGFDESNIWPTLALVGLAEENNRKK
                     LVKAYSLGMKQRLALAFALVKKPKILLLDEPTN"
     CDS             complement(7906..9978)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_C39"
                     /gene_functions="transport (smcogs) SMCOG1000:ABC
                     transporter ATP-binding protein (Score: 135.8; E-value:
                     3.2e-41)"
                     /gene_kind="transport"
                     /locus_tag="ctg1_1229"
                     /sec_met_domain="Peptidase_C39 (E-value: 1.1e-38, bitscore:
                     128.7, seeds: 36, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNIILQNNEEDCLLACYTMLLNDLGHKVPLYEIYDKDTLPADGLN
                     VSYLLSLSDRFGVKINAYHASFDELLKVYGEKKQRMILHWNNDHFVVLEKITSNKTVIV
                     DPAIGRIKYSRDEFLTHYSETMVSVNKRNNFHPQTYKKIFWKYFKQTLQLKPIALFLLS
                     LLFIQVSVLLFSVILRQMLAEDFKFGISLFLLGAVLIFQLLGYFIKNGALDRYNTDFDK
                     YYSKELFQRLLQKPLLYFRNHLSGGVSEKISFKSTLRDNVTLKIIPSCVSLISAIIIFA
                     YLMTISIKLSVILILMIASYSIISTLLYHRQNEYNQTYLQYLIDFNSELQTDLDDIDYI
                     KIMRREKTVFHSWMEQNNQVTKKYSQILKIENLSQLIGTIFNYISLSSIIVIAVYYKDY
                     INLSLPDLLVYQTSISLLISAIEQVKGAVFEVIRLGVYAEKQSDLLKDTSPIVVPSSQS
                     DDYLIKTKNLNFSYGNKPIYSDVNLTISKGEKIAIVGKSGSGKSTLLLMLAGMLRYDGS
                     LEYGIEKFKDNLRVVLQNMTPRKGTVLENLEWTLDDVTPLYQVLNDTTADEVIARLPNK
                     IHSRLLKQGKNLSGGQIQKLLIAKSLLKENSIIFWDEAFSNLDEQSKNKIYDNVLQNNR
                     YSDRTMLIVSHHLDIVNYVDSIIFIDNETGKVIKDTHEHLMETNVNYTNFITSKN"
     PFAM_domain     complement(8134..8544)
                     /aSDomain="ABC_tran"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00005.29"
                     /description="ABC transporter"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_1229_0086"
                     /evalue="3.30E-22"
                     /label="ctg1_1229"
                     /locus_tag="ctg1_1229"
                     /protein_end="615"
                     /protein_start="478"
                     /score="79.6"
                     /tool="antismash"
                     /translation="SDVNLTISKGEKIAIVGKSGSGKSTLLLMLAGMLRYDGSLEYGIE
                     KFKDNLRVVLQNMTPRKGTVLENLEWTLDDVTPLYQVLNDTTADEVIARLPNKIHSRLL
                     KQGKNLSGGQIQKLLIAKSLLKENSIIFWDEAF"
     PFAM_domain     complement(8719..9489)
                     /aSDomain="ABC_membrane"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00664.25"
                     /description="ABC transporter transmembrane region"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_1229_0085"
                     /evalue="1.60E-16"
                     /label="ctg1_1229"
                     /locus_tag="ctg1_1229"
                     /protein_end="420"
                     /protein_start="163"
                     /score="60.8"
                     /tool="antismash"
                     /translation="LLFIQVSVLLFSVILRQMLAEDFKFGISLFLLGAVLIFQLLGYFI
                     KNGALDRYNTDFDKYYSKELFQRLLQKPLLYFRNHLSGGVSEKISFKSTLRDNVTLKII
                     PSCVSLISAIIIFAYLMTISIKLSVILILMIASYSIISTLLYHRQNEYNQTYLQYLIDF
                     NSELQTDLDDIDYIKIMRREKTVFHSWMEQNNQVTKKYSQILKIENLSQLIGTIFNYIS
                     LSSIIVIAVYYKDYINLSLPDLLVYQTSISLLISA"
     PFAM_domain     complement(9580..9975)
                     /aSDomain="Peptidase_C39"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF03412.17"
                     /description="Peptidase C39 family"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_1229_0084"
                     /evalue="1.20E-37"
                     /label="ctg1_1229"
                     /locus_tag="ctg1_1229"
                     /protein_end="133"
                     /protein_start="1"
                     /score="128.7"
                     /tool="antismash"
                     /translation="NIILQNNEEDCLLACYTMLLNDLGHKVPLYEIYDKDTLPADGLNV
                     SYLLSLSDRFGVKINAYHASFDELLKVYGEKKQRMILHWNNDHFVVLEKITSNKTVIVD
                     PAIGRIKYSRDEFLTHYSETMVSVNKRN"
     CDS             complement(10001..12784)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-ii: DUF4135"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-ii: LANC_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1070:lanthionine synthetase C family protein (Score:
                     702.8; E-value: 1.2e-212)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg1_1230"
                     /sec_met_domain="LANC_like (E-value: 2.1e-67, bitscore:
                     224.0, seeds: 47, tool: rule-based-clusters)"
                     /sec_met_domain="DUF4135 (E-value: 3.4e-79, bitscore:
                     263.3, seeds: 79, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNPKELLYSQFDRFPKVVIENNFPELLNESSELIKDVEDEISDYY
                     RSTLIYLINEKRIEKNLIGDSPESRYEYFNNVLCQNGLIFEEIDRRFPSINQRVMSTIK
                     KCLELINFVKERFTLDFKELRETGYIYSEAQTPKISEVKIKITGDIHNGCGVCILSYEE
                     QKVVFKKKSSNPNVLLHELNIEVGKFLQKDIDFIPDFLDKGEYFWEKFVSSSPLRTEED
                     AKEFYRRMGYLLSYSYILNISDLHFENLISTSFSPKLVDVETVFSVSPYQTVANNESTL
                     EIINNSRNSILSTGLLPVSEAGKVFGGDTSGVLGGTLIGEAKIVINHNRDDIHVEKQKF
                     KTENQDHLPYFIDSKGMKEFLNAEDYVEYIKEGFREVSYFFMNSQDFLKKLYIKHNDIK
                     TRILFRNTRDYSLVRQLLVSPVYCEQSEILFETMANKLSEQNSRSLCLSEKKQLLNMDI
                     PYFYSNIDSCDIKDENMIIWNLESSALSEAINKLEKLSEEIINEQIELIEFSIKTPKAL
                     YSTELQEAYQKFEKVSSSENIIKTGIDTLVDIILENESNSLKDDSTNWLTLKVTDYDAF
                     ELVPMDDSLYEGLSGIAISLSEAYDFLDSGRQRRVKECLKRIFSVLSNSYMKLPNHSFF
                     VGKLGIYSALKRISVVTGQEIQNSIMNYNNLKYTLDVDVLSADFLSSFPNEITALRNSD
                     IKIDNLTQALDKLKELAIVQKDFISWDKLESNNVSLAHGNLGVEIALLYLAGKLESPEA
                     LNLFHKAKMFDKHQKLENGWIDKRNSSTSANWCHGSTGVLVARLAQLKLDDEYSLLSHS
                     ERIELENDMKHAAKQILEIGFDMTNFSLCHGTSGNLLALTYYQSYLTGADSEKLKEILD
                     REYRKLHSFGLENGWMCSFNTKYNVYGLMTGVSGILFSTVKYMKGDDSLDVLIPNF"
     PFAM_domain     complement(10025..11047)
                     /aSDomain="LANC_like"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF05147.15"
                     /description="Lanthionine synthetase C-like protein"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_1230_0088"
                     /evalue="1.90E-67"
                     /label="ctg1_1230"
                     /locus_tag="ctg1_1230"
                     /protein_end="920"
                     /protein_start="579"
                     /score="227.4"
                     /tool="antismash"
                     /translation="PMDDSLYEGLSGIAISLSEAYDFLDSGRQRRVKECLKRIFSVLSN
                     SYMKLPNHSFFVGKLGIYSALKRISVVTGQEIQNSIMNYNNLKYTLDVDVLSADFLSSF
                     PNEITALRNSDIKIDNLTQALDKLKELAIVQKDFISWDKLESNNVSLAHGNLGVEIALL
                     YLAGKLESPEALNLFHKAKMFDKHQKLENGWIDKRNSSTSANWCHGSTGVLVARLAQLK
                     LDDEYSLLSHSERIELENDMKHAAKQILEIGFDMTNFSLCHGTSGNLLALTYYQSYLTG
                     ADSEKLKEILDREYRKLHSFGLENGWMCSFNTKYNVYGLMTGVSGILFSTVKYMKGDDS
                     L"
     aSDomain        complement(10049..12694)
                     /aSDomain="TIGR03897"
                     /aSTool="tigrfam"
                     /description="lanti_2_LanM: type 2 lantibiotic biosynthesis
                     protein LanM"
                     /detection="hmmscan"
                     /domain_id="TIGRFam_ctg1_1230_0034"
                     /evalue="7.20E-131"
                     /identifier="TIGR03897"
                     /label="ctg1_1230"
                     /locus_tag="ctg1_1230"
                     /protein_end="912"
                     /protein_start="30"
                     /score="435.7"
                     /tool="antismash"
                     /translation="SELIKDVEDEISDYYRSTLIYLINEKRIEKNLIGDSPESRYEYFN
                     NVLCQNGLIFEEIDRRFPSINQRVMSTIKKCLELINFVKERFTLDFKELRETGYIYSEA
                     QTPKISEVKIKITGDIHNGCGVCILSYEEQKVVFKKKSSNPNVLLHELNIEVGKFLQKD
                     IDFIPDFLDKGEYFWEKFVSSSPLRTEEDAKEFYRRMGYLLSYSYILNISDLHFENLIS
                     TSFSPKLVDVETVFSVSPYQTVANNESTLEIINNSRNSILSTGLLPVSEAGKVFGGDTS
                     GVLGGTLIGEAKIVINHNRDDIHVEKQKFKTENQDHLPYFIDSKGMKEFLNAEDYVEYI
                     KEGFREVSYFFMNSQDFLKKLYIKHNDIKTRILFRNTRDYSLVRQLLVSPVYCEQSEIL
                     FETMANKLSEQNSRSLCLSEKKQLLNMDIPYFYSNIDSCDIKDENMIIWNLESSALSEA
                     INKLEKLSEEIINEQIELIEFSIKTPKALYSTELQEAYQKFEKVSSSENIIKTGIDTLV
                     DIILENESNSLKDDSTNWLTLKVTDYDAFELVPMDDSLYEGLSGIAISLSEAYDFLDSG
                     RQRRVKECLKRIFSVLSNSYMKLPNHSFFVGKLGIYSALKRISVVTGQEIQNSIMNYNN
                     LKYTLDVDVLSADFLSSFPNEITALRNSDIKIDNLTQALDKLKELAIVQKDFISWDKLE
                     SNNVSLAHGNLGVEIALLYLAGKLESPEALNLFHKAKMFDKHQKLENGWIDKRNSSTSA
                     NWCHGSTGVLVARLAQLKLDDEYSLLSHSERIELENDMKHAAKQILEIGFDMTNFSLCH
                     GTSGNLLALTYYQSYLTGADSEKLKEILDREYRKLHSFGLENGWMCSFNTKYNVYGLMT
                     GVSGILFSTVK"
     PFAM_domain     complement(11396..12511)
                     /aSDomain="DUF4135"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF13575.8"
                     /description="Domain of unknown function (DUF4135)"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_1230_0087"
                     /evalue="2.10E-60"
                     /label="ctg1_1230"
                     /locus_tag="ctg1_1230"
                     /protein_end="463"
                     /protein_start="91"
                     /score="205.0"
                     /tool="antismash"
                     /translation="FPSINQRVMSTIKKCLELINFVKERFTLDFKELRETGYIYSEAQT
                     PKISEVKIKITGDIHNGCGVCILSYEEQKVVFKKKSSNPNVLLHELNIEVGKFLQKDID
                     FIPDFLDKGEYFWEKFVSSSPLRTEEDAKEFYRRMGYLLSYSYILNISDLHFENLISTS
                     FSPKLVDVETVFSVSPYQTVANNESTLEIINNSRNSILSTGLLPVSEAGKVFGGDTSGV
                     LGGTLIGEAKIVINHNRDDIHVEKQKFKTENQDHLPYFIDSKGMKEFLNAEDYVEYIKE
                     GFREVSYFFMNSQDFLKKLYIKHNDIKTRILFRNTRDYSLVRQLLVSPVYCEQSEILFE
                     TMANKLSEQNSRSLCLSEKKQLLNMDIPYFYS"
     CDS             complement(12805..12960)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) L_biotic_A"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) leader_d"
                     /gene_functions="biosynthetic-additional (lanthipeptides)
                     predicted lanthipeptide"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg1_1231"
                     /sec_met_domain="L_biotic_A (E-value: 1.2e-24, bitscore:
                     82.6, seeds: 15, tool: rule-based-clusters)"
                     /sec_met_domain="leader_d (E-value: 2.6e-05, bitscore:
                     20.9, seeds: 16, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MEEKMCLGALNALQEFQIEELDNLLGGRGHGVNTISAECRWNSLQ
                     AIFTCC"
     CDS_motif       complement(12880..12960)
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence: MEEKMCLGALNALQEFQIEELDNLLGG"
                     /locus_tag="ctg1_1231_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       complement(12805..12879)
                     /prepeptide="core"
                     /locus_tag="ctg1_1231_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class II"
                     /score="3.80"
                     /molecular_weight="2594.9"
                     /monoisotopic_mass="2593.2"
                     /core_sequence="RGHGVNTISAECRWNSLQAIFTCC"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MEEKMCLGALNALQEFQIEELDNLLGG"
                     /leader_location="[12879:12960](-)"
                     /alternative_weights="2613.0"
     PFAM_domain     complement(12808..12960)
                     /aSDomain="L_biotic_typeA"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF04604.15"
                     /description="Type-A lantibiotic"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_1231_0089"
                     /evalue="1.40E-23"
                     /label="ctg1_1231"
                     /locus_tag="ctg1_1231"
                     /protein_end="51"
                     /protein_start="0"
                     /score="82.6"
                     /tool="antismash"
                     /translation="MEEKMCLGALNALQEFQIEELDNLLGGRGHGVNTISAECRWNSLQ
                     AIFTCC"
     CDS             complement(13160..13315)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) L_biotic_A"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) leader_d"
                     /gene_functions="biosynthetic-additional (lanthipeptides)
                     predicted lanthipeptide"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg1_1232"
                     /sec_met_domain="L_biotic_A (E-value: 3.4e-27, bitscore:
                     90.7, seeds: 15, tool: rule-based-clusters)"
                     /sec_met_domain="leader_d (E-value: 5e-06, bitscore: 23.1,
                     seeds: 16, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTKEHEIINSIQEVSLEELDQIIGAGKNGVFKTISHECHLNTWAF
                     LATCCS"
     CDS_motif       complement(13241..13315)
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence: MTKEHEIINSIQEVSLEELDQIIGA"
                     /locus_tag="ctg1_1232_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       complement(13160..13240)
                     /prepeptide="core"
                     /locus_tag="ctg1_1232_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class II"
                     /score="5.20"
                     /molecular_weight="2778.2"
                     /monoisotopic_mass="2776.3"
                     /core_sequence="GKNGVFKTISHECHLNTWAFLATCCS"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MTKEHEIINSIQEVSLEELDQIIGA"
                     /leader_location="[13240:13315](-)"
                     /alternative_weights="2796.2"
                     /alternative_weights="2814.2"
     PFAM_domain     complement(13166..13315)
                     /aSDomain="L_biotic_typeA"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF04604.15"
                     /description="Type-A lantibiotic"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_1232_0090"
                     /evalue="4.00E-26"
                     /label="ctg1_1232"
                     /locus_tag="ctg1_1232"
                     /protein_end="50"
                     /protein_start="0"
                     /score="90.7"
                     /tool="antismash"
                     /translation="MTKEHEIINSIQEVSLEELDQIIGAGKNGVFKTISHECHLNTWAF
                     LATCC"
     CDS             complement(13346..13501)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) L_biotic_A"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) leader_d"
                     /gene_functions="biosynthetic-additional (lanthipeptides)
                     predicted lanthipeptide"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg1_1233"
                     /sec_met_domain="L_biotic_A (E-value: 9.7e-28, bitscore:
                     92.5, seeds: 15, tool: rule-based-clusters)"
                     /sec_met_domain="leader_d (E-value: 5e-06, bitscore: 23.1,
                     seeds: 16, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MEKNNEVINSIQEVSLEELDQIIGAGKNGVFKTISHECHLNTWAF
                     LATCCS"
     CDS_motif       complement(13427..13501)
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence: MEKNNEVINSIQEVSLEELDQIIGA"
                     /locus_tag="ctg1_1233_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       complement(13346..13426)
                     /prepeptide="core"
                     /locus_tag="ctg1_1233_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class II"
                     /score="5.20"
                     /molecular_weight="2778.2"
                     /monoisotopic_mass="2776.3"
                     /core_sequence="GKNGVFKTISHECHLNTWAFLATCCS"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MEKNNEVINSIQEVSLEELDQIIGA"
                     /leader_location="[13426:13501](-)"
                     /alternative_weights="2796.2"
                     /alternative_weights="2814.2"
     PFAM_domain     complement(13352..13501)
                     /aSDomain="L_biotic_typeA"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF04604.15"
                     /description="Type-A lantibiotic"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_1233_0091"
                     /evalue="1.10E-26"
                     /label="ctg1_1233"
                     /locus_tag="ctg1_1233"
                     /protein_end="50"
                     /protein_start="0"
                     /score="92.5"
                     /tool="antismash"
                     /translation="MEKNNEVINSIQEVSLEELDQIIGAGKNGVFKTISHECHLNTWAF
                     LATCC"
     CDS             13699..14397
                     /gene_functions="regulatory (smcogs) SMCOG1008:response
                     regulator (Score: 184.3; E-value: 4.1e-56)"
                     /gene_kind="regulatory"
                     /locus_tag="ctg1_1234"
                     /transl_table=11
                     /translation="MNFESQLLNKRILIVDDDVALSKSIKEVLISRDFKNISCAYSISE
                     GIDIFSVSKIDLIILDVMLPDGEGHLLAKYIRKYSDVPILFLTAKNNPDDEIRGLESGG
                     DDYVTKPFLPKSLTYRIIALLRRAYKDESELIELTNCTIDLNNASVEKNGQHLSLTPTE
                     IQILRKLFSNKNYIASTESICDTVWGLESLGYEKSLMVHIRNIREKIEITPSKPNHLIT
                     VKGLGYKLVI"
     PFAM_domain     13732..14061
                     /aSDomain="Response_reg"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00072.26"
                     /description="Response regulator receiver domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_1234_0092"
                     /evalue="1.30E-23"
                     /label="ctg1_1234"
                     /locus_tag="ctg1_1234"
                     /protein_end="121"
                     /protein_start="11"
                     /score="83.4"
                     /tool="antismash"
                     /translation="ILIVDDDVALSKSIKEVLISRDFKNISCAYSISEGIDIFSVSKID
                     LIILDVMLPDGEGHLLAKYIRKYSDVPILFLTAKNNPDDEIRGLESGGDDYVTKPFLPK
                     SLTYRI"
     PFAM_domain     14158..14388
                     /aSDomain="Trans_reg_C"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00486.30"
                     /description="Transcriptional regulatory protein, C
                     terminal"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_1234_0093"
                     /evalue="3.40E-18"
                     /label="ctg1_1234"
                     /locus_tag="ctg1_1234"
                     /protein_end="230"
                     /protein_start="153"
                     /score="65.6"
                     /tool="antismash"
                     /translation="GQHLSLTPTEIQILRKLFSNKNYIASTESICDTVWGLESLGYEKS
                     LMVHIRNIREKIEITPSKPNHLITVKGLGYKL"
     CDS             14415..15776
                     /gene_functions="regulatory (smcogs) SMCOG1003:sensor
                     histidine kinase (Score: 115; E-value: 8.4e-35)"
                     /gene_kind="regulatory"
                     /locus_tag="ctg1_1235"
                     /transl_table=11
                     /translation="MNIFKKNILKFILSFFFIIIIDVILLITATNYIRSQQSASTIIET
                     VSSEITLSSNGKYNVSSKAKQLIDDKKLWIMIIDKDNGKEKFNINKPQIIENQFDFADA
                     IRFSRFYLKDYPVFTQIKDNDIYIIAFPKDSIIRYSSNYFELNRVQIFPILILSIIFAN
                     CLFCLFLYIYSVTFLNRNIKPIINAITKLPNGINTQVKSVRELDKLTLAINSANQQLRE
                     NEEFKENWISGIAHDIKTPLSVIVSNTSLAIEKTNDDEFLKHLKPTLVESHYIQNLLND
                     LNIFARLTNGNLKLNHEIVDIIPFFKEIIIQIINQEIWEDFNFEFIPDSKLLGKKMYIE
                     KALISRVVHNLIYNSVLHNHSGCDIKIILEYLPEDCFSITIRDNGIGTSPERLKNINKI
                     EEFNFDMSGVRRSGMGLKISKQIIDLHDGNMIITSTQGQYFQTVITLPIESLNT"
     PFAM_domain     15093..15287
                     /aSDomain="HisKA"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00512.27"
                     /description="His Kinase A (phospho-acceptor) domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_1235_0094"
                     /evalue="3.60E-08"
                     /label="ctg1_1235"
                     /locus_tag="ctg1_1235"
                     /protein_end="291"
                     /protein_start="226"
                     /score="33.4"
                     /tool="antismash"
                     /translation="KENWISGIAHDIKTPLSVIVSNTSLAIEKTNDDEFLKHLKPTLVE
                     SHYIQNLLNDLNIFARLTNG"
     PFAM_domain     15444..15758
                     /aSDomain="HATPase_c"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF02518.28"
                     /description="Histidine kinase-, DNA gyrase B-, and
                     HSP90-like ATPase"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_1235_0095"
                     /evalue="4.50E-13"
                     /label="ctg1_1235"
                     /locus_tag="ctg1_1235"
                     /protein_end="448"
                     /protein_start="343"
                     /score="49.8"
                     /tool="antismash"
                     /translation="ISRVVHNLIYNSVLHNHSGCDIKIILEYLPEDCFSITIRDNGIGT
                     SPERLKNINKIEEFNFDMSGVRRSGMGLKISKQIIDLHDGNMIITSTQGQYFQTVITLP
                     I"
     CDS             complement(15993..16382)
                     /locus_tag="ctg1_1236"
                     /transl_table=11
                     /translation="MEIHTPDQTFLETKDQLVQEIATLDMKIEEIQEKIATLNKMAEVF
                     INLESDNKEGKRLARYNLTKTNIPLTIKVDQVEREIEQLQISLTERLDEYEGKVSELEE
                     FVQMLNTLELPLTDRDHLDRNRLAF"
     PFAM_domain     complement(16050..16322)
                     /aSDomain="Streptin-Immun"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF11083.10"
                     /description="Lantibiotic streptin immunity protein"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_1236_0096"
                     /evalue="3.00E-31"
                     /label="ctg1_1236"
                     /locus_tag="ctg1_1236"
                     /protein_end="111"
                     /protein_start="20"
                     /score="107.7"
                     /tool="antismash"
                     /translation="IATLDMKIEEIQEKIATLNKMAEVFINLESDNKEGKRLARYNLTK
                     TNIPLTIKVDQVEREIEQLQISLTERLDEYEGKVSELEEFVQMLNT"
     CDS             16528..16803
                     /gene_functions="other (smcogs) SMCOG1164:transposase
                     IS3/IS911 family protein (Score: 67.1; E-value: 1.8e-20)"
                     /gene_kind="other"
                     /locus_tag="ctg1_1237"
                     /transl_table=11
                     /translation="MSTVKRYDEEFKQSLVNLYQTGKTQSELCKDYGVSASALAKWIKQ
                     YSQVKLEDNSVLTAKQIQELQKRNAQLEEENLILKKASAIFMQNLK"
     PFAM_domain     16534..16755
                     /aSDomain="HTH_Tnp_1"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF01527.22"
                     /description="Transposase"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_1237_0097"
                     /evalue="3.40E-14"
                     /label="ctg1_1237"
                     /locus_tag="ctg1_1237"
                     /protein_end="76"
                     /protein_start="2"
                     /score="53.0"
                     /tool="antismash"
                     /translation="TVKRYDEEFKQSLVNLYQTGKTQSELCKDYGVSASALAKWIKQYS
                     QVKLEDNSVLTAKQIQELQKRNAQLEEEN"
     CDS             16923..17654
                     /gene_functions="other (smcogs) SMCOG1026:transposase
                     (Score: 252; E-value: 1e-76)"
                     /gene_kind="other"
                     /locus_tag="ctg1_1238"
                     /transl_table=11
                     /translation="LDNQIYKKQILEIYTKANKRLGVKSIKVILQRDYDTKISEGRIYR
                     LMKNMALPKMATVKPKTALKRTQKTYPQNLLNQKFNPDKPNQVWSTDFTYISIGYKKYV
                     YLCAILDLYSRKCIAWRLSHHMDAKLACDTLELALNKRKIEGTLLFHSDQGSQFKAREL
                     RKIIDDNTIMHSFSKPGYPYDNAVTEAFFKYLKHRQINRKKYQNIKQVQLDCFEYIENF
                     YNNYNPHTANLGLNPNQKEEN"
     PFAM_domain     16941..17078
                     /aSDomain="HTH_21"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF13276.8"
                     /description="HTH-like domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_1238_0098"
                     /evalue="1.10E-08"
                     /label="ctg1_1238"
                     /locus_tag="ctg1_1238"
                     /protein_end="52"
                     /protein_start="6"
                     /score="35.1"
                     /tool="antismash"
                     /translation="KKQILEIYTKANKRLGVKSIKVILQRDYDTKISEGRIYRLMKNMA
                     L"
     PFAM_domain     17169..17468
                     /aSDomain="rve"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00665.28"
                     /description="Integrase core domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_1238_0099"
                     /evalue="6.70E-26"
                     /label="ctg1_1238"
                     /locus_tag="ctg1_1238"
                     /protein_end="182"
                     /protein_start="82"
                     /score="90.6"
                     /tool="antismash"
                     /translation="DKPNQVWSTDFTYISIGYKKYVYLCAILDLYSRKCIAWRLSHHMD
                     AKLACDTLELALNKRKIEGTLLFHSDQGSQFKARELRKIIDDNTIMHSFSKPGYP"
     PFAM_domain     17487..17603
                     /aSDomain="rve_2"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF13333.8"
                     /description="Integrase core domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_1238_0100"
                     /evalue="8.40E-05"
                     /label="ctg1_1238"
                     /locus_tag="ctg1_1238"
                     /protein_end="227"
                     /protein_start="188"
                     /score="22.8"
                     /tool="antismash"
                     /translation="EAFFKYLKHRQINRKKYQNIKQVQLDCFEYIENFYNNYN"
     CDS             complement(18049..18264)
                     /gene="allorf_1307948_1308163"
                     /gene_functions="biosynthetic-additional (lanthipeptides)
                     predicted lanthipeptide"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="allorf_1307948_1308163"
                     /protein_id="allorf_1307948_1308163"
                     /tool="antismash"
                     /transl_table=1
                     /translation="VKIYKNCLELANKLSGYHCSVFEFPYKKIKKFFKHELYSRHHYII
                     VRLDGSMEYRFSSVALKNKIKSILDS"
     CDS_motif       complement(18217..18264)
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence: VKIYKNCLELANKLSG"
                     /locus_tag="allorf_1307948_1308163_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       complement(18049..18216)
                     /prepeptide="core"
                     /locus_tag="allorf_1307948_1308163_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class II"
                     /score="-6.40"
                     /molecular_weight="6602.7"
                     /monoisotopic_mass="6598.5"
                     /core_sequence="YHCSVFEFPYKKIKKFFKHELYSRHHYIIVRLDGSMEYRFSSV
                     ALKNKIKSILDS"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="VKIYKNCLELANKLSG"
                     /leader_location="[18216:18264](-)"
                     /alternative_weights="6620.7"
                     /alternative_weights="6638.7"
                     /alternative_weights="6656.7"
                     /alternative_weights="6674.7"
                     /alternative_weights="6692.8"
                     /alternative_weights="6710.8"
     CDS             complement(18267..18818)
                     /locus_tag="ctg1_1239"
                     /transl_table=11
                     /translation="VDEFKGIKVEFIQLSNKNIFDVLEKDLSKKLRFEDISIEAILGKY
                     LCNNDIEIIKCLYEKDKINMELLISLISKISNKLVKQEFIKVLDLYEYVKNFLPVDCIY
                     FSLSNLYGTGHYSSMNYKIFIRTKSGDIFDIADGGRIDDMVSKFNKVNVLGVCMGIGTT
                     VLSQEIEYEIEDRIMILVEK"
     CDS             complement(19034..19126)
                     /locus_tag="ctg1_1240"
                     /transl_table=11
                     /translation="MTTVVEQARLDEIATSVLSRHLDAFKELTE"
     CDS             complement(19123..19254)
                     /locus_tag="ctg1_1241"
                     /transl_table=11
                     /translation="MELVKTIQIGDDIYPPIPDPFGIQENQEFNLYKSTDGTLVMSR"
     CDS             complement(19317..19577)
                     /locus_tag="ctg1_1242"
                     /transl_table=11
                     /translation="MKEYQVTMSDDAKADLLNIYHYVRDELCAPQAADNLLERLSQGML
                     SLSIFPERCAIIEDLIGKGYTFRQLIEKNIALYIMFWKMKL"
     aSDomain        complement(19341..19565)
                     /aSDomain="TIGR02385"
                     /aSTool="tigrfam"
                     /description="RelE_StbE: addiction module toxin, RelE/StbE
                     family"
                     /detection="hmmscan"
                     /domain_id="TIGRFam_ctg1_1242_0035"
                     /evalue="6.20E-09"
                     /identifier="TIGR02385"
                     /label="ctg1_1242"
                     /locus_tag="ctg1_1242"
                     /protein_end="79"
                     /protein_start="4"
                     /score="34.2"
                     /tool="antismash"
                     /translation="QVTMSDDAKADLLNIYHYVRDELCAPQAADNLLERLSQGMLSLSI
                     FPERCAIIEDLIGKGYTFRQLIEKNIALYI"
     PFAM_domain     complement(19410..19559)
                     /aSDomain="ParE_toxin"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF05016.17"
                     /description="ParE toxin of type II toxin-antitoxin system,
                     parDE"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_1242_0101"
                     /evalue="1.20E-05"
                     /label="ctg1_1242"
                     /locus_tag="ctg1_1242"
                     /protein_end="56"
                     /protein_start="6"
                     /score="26.0"
                     /tool="antismash"
                     /translation="TMSDDAKADLLNIYHYVRDELCAPQAADNLLERLSQGMLSLSIFP
                     ERCAI"
     CDS             complement(19577..19879)
                     /locus_tag="ctg1_1243"
                     /transl_table=11
                     /translation="MAKTGTLNLRVDDSVKSAADDILKRLGIPMSTAIDMFLNQIILTG
                     GIPFDVSLPEAPQRVNVDYMSQEKFYDKLITSFEDAKTGNRQDVREFLFQLKENA"
     aSDomain        complement(19634..19879)
                     /aSDomain="TIGR02384"
                     /aSTool="tigrfam"
                     /description="RelB_DinJ: addiction module antitoxin,
                     RelB/DinJ family"
                     /detection="hmmscan"
                     /domain_id="TIGRFam_ctg1_1243_0036"
                     /evalue="9.30E-27"
                     /identifier="TIGR02384"
                     /label="ctg1_1243"
                     /locus_tag="ctg1_1243"
                     /protein_end="82"
                     /protein_start="0"
                     /score="91.1"
                     /tool="antismash"
                     /translation="MAKTGTLNLRVDDSVKSAADDILKRLGIPMSTAIDMFLNQIILTG
                     GIPFDVSLPEAPQRVNVDYMSQEKFYDKLITSFEDAK"
     PFAM_domain     complement(19715..19867)
                     /aSDomain="RelB"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF04221.14"
                     /description="RelB antitoxin"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_1243_0102"
                     /evalue="3.00E-11"
                     /label="ctg1_1243"
                     /locus_tag="ctg1_1243"
                     /protein_end="55"
                     /protein_start="4"
                     /score="43.1"
                     /tool="antismash"
                     /translation="GTLNLRVDDSVKSAADDILKRLGIPMSTAIDMFLNQIILTGGIPF
                     DVSLPE"
     CDS             complement(19934..20092)
                     /locus_tag="ctg1_1244"
                     /transl_table=11
                     /translation="MGQAPAGNIKPDKEKSVEKIDGIVGLILVLDRCIRRQGDEASVYD
                     ERGILSF"
     CDS             20135..21019
                     /locus_tag="ctg1_1245"
                     /transl_table=11
                     /translation="MLDFPFHHEFIEFLGRWTHILITLPKRHHGQVDTAIPRYLLVTIR
                     EKTGIVKSTTVQNTAFTTQSNQLKKQYGQFLLTESNNCCACPGCDRPLILTSGNLAAEN
                     YEVSAIEKDKDAEPLNLIALCPDCFLTYQADSRKKIVTALKNVKKILVSAHNSQQAISD
                     MKLDSGIVSVLTSLNKLKCDEYDISYDSKQLTDKISPENNRTLYQLVKNQVIDNYLTIQ
                     KIIVNLDKQGKIDYEEIQYQTRSMYKKLKAAKHNNLAIFNTISEKLHKATLQDIYFCQT
                     IVSYFIQKCEVLE"
     CDS             21019..21243
                     /gene_functions="biosynthetic-additional (lanthipeptides)
                     predicted lanthipeptide"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg1_1246"
                     /transl_table=11
                     /translation="MQLPNKLYSYQKSTLAYLPRVLNEIKSGNSNVKDIFHAISEELDD
                     PTDFLSIMDCLYALNAIEMSNEGEVKLCL"
     CDS_motif       21019..21132
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence:
                     MQLPNKLYSYQKSTLAYLPRVLNEIKSGNSNVKDIFHA"
                     /locus_tag="ctg1_1246_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       21133..21243
                     /prepeptide="core"
                     /locus_tag="ctg1_1246_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class II"
                     /score="-7.00"
                     /molecular_weight="3963.5"
                     /monoisotopic_mass="3960.9"
                     /core_sequence="ISEELDDPTDFLSIMDCLYALNAIEMSNEGEVKLCL"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MQLPNKLYSYQKSTLAYLPRVLNEIKSGNSNVKDIFHA"
                     /leader_location="[21018:21132](+)"
                     /alternative_weights="3981.5"
                     /alternative_weights="3999.5"
ORIGIN
        1 accctttctt gatattcgca ttctcaaaat tccctctcta acctttggcc tgattccctt
       61 ttttgtcttc cagctgatta atttaggcat aaattttcta acgccaaact ttattgtcat
      121 ggaaaagatt gctaatagtt ctcaagctgg tatggtgtta ctacctggta ccttactcgg
      181 agctctacta gcacctgctt ttggtaaact ttatgatcaa aaaggagcaa aactttcgct
      241 ttatttagga aatgccttat ttagtttatc attgattatt atgacacttc aaacaagaca
      301 ttttatgctt ttaccattca ctcttttata tattttattc acgtttgggc gtaacatggg
      361 ctttaataat agcttagcca cggctattcg agaattgcct gccgagaaaa atgccgatgc
      421 cacggccatt tttcagatga tgcagcaatt tgctggcgct ctaggaactg ctatggcatc
      481 actgatagct aatagtcagc cagaattcac aagcggtgtc cagtctgtct accttctctt
      541 tactattttt gctctacttg attttatctt tttctttgct atgttttacc atttagggaa
      601 aaaaggactt gcctaagcta acttacttaa aaaccagcct cgttctgttg aacaagactg
      661 gtttttttct tataaaatac cttctaaaag acctttcata aagtcttctg agtggaattc
      721 tccaatatca tccacttttt caccaaatcc gatgaacttg actggaatgt ctaattcttg
      781 acggatggct aggaccaccc caccttttgc agtcccatca attttcgtta aaattaagcc
      841 tgttaaaggt gttatttttg aaaattcctt ggcttggcta agcgcatttt gacctgttga
      901 cgcatctaag gccaaaagcg tttcatgagg ggcatctggt agcacgcgct taatgatacg
      961 acccattttt tccagctctg ccatgagatt ttctttgttt tgcaggcgac cagccgtgtc
     1021 aatcaggaga atatctacac cttttgccac agctttttcc atcccgtcaa aaacaacaga
     1081 cgctggatca gccttttcag ggccagtaat gactggcaca tctactcggc gtccccattc
     1141 gactagctga gccacagccc ctgctcggaa ggtatctgct gccaccaaca tgactttttt
     1201 accttcttgt ttgtaacggt aagccagctt cccgattgaa gtcgttttac caaccccgtt
     1261 aacacctaca aaaagcataa ccgtcaagcc atcttgataa ttaatggctt cattataacg
     1321 cccatctttt tcatagatat ctaccaattt ttccacaatc acacgtttca aggcatctgg
     1381 ttttttcgca ttttccagtt tggcttcata acgcaactcc tctgtcaaag ttgtcgccac
     1441 atgtacaccg acatctgata agatcagcat ttcttccaag tcttcaaaga attcttcatc
     1501 cactcgcctg aaattggcaa agaaactgtt cagacgagct gagaagccag tccgcgtttt
     1561 tttcaagcta cgcttgtatt tttcttgatc tgtctcagga atggtatcgt gggttgcctt
     1621 gttttgagaa gcttctgctg aggtagaggc ctgattttct tgtggaacct cttctggcat
     1681 cactggaacc gttgccgctg ctttttcttg aaggcttttt tcaagagcag ccttacgacg
     1741 gtagtagtct tccataacct gttggctact ggattgctct tttgaagtgt ctactgcttc
     1801 ttcattcgcc gaatcatttg aggcatcagc ttgggcttgt tttgttggaa actgttccac
     1861 aactggctgg tcaacaaggt cttttggttc tgatgccgta gattgactaa gttcacttac
     1921 cttaaggtct gttttgtcgg cagcaaactc attggtatct tctgatggat gattactatt
     1981 gtcacctgtt tcttcctcaa ccagtgcgtt tactgaagct gcttcgggac cattttccac
     2041 cgaacctgcg ccctctgaag aaacgtcctc ttgttgaacc gcctcaatct tgtcttgctc
     2101 attggctttt tcagaaagct cctctttctg agttgtttct gtcaaaagat tttcttctaa
     2161 cttttcctca gctaccttcg gggtttcttt tttcccaaat aaacgatcaa ataatcccat
     2221 taactctcct cttctaaaat aaatgtcttc acagcttctg caactccaga ctcatcattg
     2281 gtcaaggtgg tcacggcatc ggcaacggct ttagctcctg aaacaccatt agccatagct
     2341 actccaagtc ctgcccattc taacatcgca aagtcgttag cttcgtctcc catagccatg
     2401 acatgtctag cttcaaggcc aaggtgctgg caaagcaagt ttaatccaaa agctttatca
     2461 atgccttttg gcatgatttc aaaaataata tctcgtgatt taaaggcttc aaaatcctca
     2521 aataagcttg gggatagctt tataatctgc tgatccaaaa agtctggatc ggtgactgtc
     2581 acaattttgt tataggtaat gtcttttggt agttccgcta cagatgtcac ctcaataaag
     2641 gtcaacagtg ggttagctag atggtactgc gaatgcctac cgtccttact tggaatgcta
     2701 tacacatccc caccactgat aatatctgtt ggtaagccaa ccgcctctaa agcttgctga
     2761 atctggcaaa tctggtcaaa actgagagaa ctcttatcca aaacctcccc tgtatttcgc
     2821 tgaaccaaac ccccattaaa ggtaatactg tagtcatcgt ggtcaagcaa gtccaactct
     2881 tctagcaagt taccgatggc ctttagaggg cgacctgtgg taataaccac cttaacccct
     2941 ttttctctag ccgctgctaa ggctttttta ttggcatctg tgacaatttt ttcagtgttg
     3001 tagagggttc cgtctaaatc aagcgccaaa attctaatat tcatgagtta cactagtcct
     3061 tttaaatacg ttagtactgc tccgtcatta cagtgaccaa tgacttggtc tgaaatcact
     3121 ttgatttcag gtcttgcatt ttccgtagca atagccctac cagcaaactc caacatctgg
     3181 taatcattaa aattatcccc aaaagcaatc gtttctgctt tcttaatgcc caaggcttga
     3241 caaagatgct ccataccaaa gcccttattc acctctttta agataatatc aatggaatca
     3301 aagccggtgg tcactgcagt ggcataaggg agggcttgat tcaaccaatc gcttccttct
     3361 aagacggtat ggcctgtgaa gttggtagaa actttaaaaa tggcgtcatt ctccatatct
     3421 tcaaaaccat taataacctt aacattagca tagtaatgtt ttgttttttg aatgtactct
     3481 tctgatgcgc cttttaaaat ataggctgcc ttttgcccag aaaaaaccat acctgtttct
     3541 acatagtgag gattggctaa aacctttttt gcaacttcgg tatactgctc tttggtcatc
     3601 atatctgcaa atagaatctc accatggtat tgaaccacgg aaccattttc tgcaataaca
     3661 gcaatctgat ccaaaaaggg ctcaaagagc tgatcaatgg ctaagagcga gcggccactc
     3721 gaaaccgcaa ataaaatgcc tttttcggct aactttggca agagcgcagc tagttgctct
     3781 tgattataag taccatcttc agctaggaag gtaccatcca tatctgttgc tattagttta
     3841 atcatacaat gtctcctttt tttactctag gggggtgcaa acgccattta gggtgtgcac
     3901 tttttaacga tttaaataag ccccatcatt tctgcattct gttcaatttt tcttattata
     3961 tcataaaaag cagctttcat tccattcgta aaaaacagcc agattatatt tcgataacct
     4021 gaccgttttt gaagtgaact gctacttttt ttatttttat aaatgaccac tggatgtata
     4081 ctataaaagt agacaaaact ttgtgtgtta caatctgttt taaaagacac aaaaacgaaa
     4141 ggacaaccta tgtcaacagt taaacgctac gatgaagaat ttaaacaatc ccttgtcaac
     4201 ctttatcaaa ctggaaaaac tcagtctgaa ctctgtaaag actatggggt atccgcttct
     4261 gcgcttgcaa aatggatcaa acagtattct caagtcaaac tcgaagataa ttctgtactt
     4321 actgccaagc aaatacaaga gctacaaaaa cgtaatgcgc agcttgaaga ggagaacctt
     4381 atcctaaaaa aagcaagtgc catattcatg caaaacttaa agtaagactc ctcgctgtct
     4441 atcggttacg ctttgaacac gacacaacaa ccttgtgtcg tgttttacgt gtcaatcgct
     4501 ccacttacta taaatttcta aaacataagc cctccaaaag agaattggat aatcaaattt
     4561 ataaaaaaca aatacttgag atttatacca aagcgaacaa aagacttggt gtgaagtcta
     4621 tcaaagtcat tcttcaaaga gactacgaca caaaaatctc tgaaggaaga atttaccgtc
     4681 tgatgaagaa tatggcgctt cctaaaatgg ctaccgttaa gccaaaaaca gctcttaaaa
     4741 ggactcaaaa aacgtatcct caaaacttac tcaaccagaa atttaatcct gacaaaccaa
     4801 atcaagtatg gtctactgac ttcacctata tttctattgg atataagaaa tatgtctatc
     4861 tctgcgcaat acttgatctc tattctagaa aatgtattgc ttggaaactg agtcatcata
     4921 tggatgcaaa gttagcatgt gacactctag aattagctct taataaaaga aagattgaag
     4981 gagcacttct ctttcattcc gaccaagggt cacaatttaa ggccagggaa ttgagaaaaa
     5041 taattgatga caacactatc atgcattctt tttctaaacc tggatatcct tatgataatg
     5101 ccgtaacgga agcatttttc aagtatttaa agcatagaca aatcaaccga aaaaagtatc
     5161 aaaatatcaa acaggttcaa ttagactgct ttgaatacat tgagaatttt tataacaatt
     5221 acaacccaca tacggctaat ctaggactaa accctaatca gaaagaagaa aattagttta
     5281 acgtaataaa ataacacggt tttctgtcta cttatttgac attagtccac atgctctcac
     5341 cttttccttc tataaattta gttacttctg taatgtataa aaatccactt tatccattct
     5401 tctctaaagt tcgtaatgtc aatttgaaaa aaataaaact atatagagca ttaacaacta
     5461 taaatattac gaactccgaa atgctcatat ctactaacgc tctactacgt atacctatca
     5521 ttggctggga ataagggaaa aattgattaa tgacacctcc caacataata aatatgaatc
     5581 cacaaaatga acctatagct gcaatcccga ctgatttaga aaaatttttt gttttagcca
     5641 tgatataact atgaatcatt acaacagagc tagaaccaat aacagatagc acagttgctc
     5701 ttaaaaataa aagtaaatct tttgctacaa acggaatctg gctcaatttc agtgttacaa
     5761 gatatataac aaataataat acttgtataa ctgttataag tagcaaagct aacaagaact
     5821 tactaagaag catcttttta acagatactt gatttgcacg taacatttca aatgtttttc
     5881 gctcaaattc aggtagaata atcatgcctg agaatattgc taacatagct gggaaaagca
     5941 actgactatt atagaaagtt aactgtcccc agagtactct actcatttgt tcctcaatga
     6001 gtacctcata attcaaaaag aaatttgcca aaccaatgaa actagataga acaagaaata
     6061 taatcccaac tgctaaaata gctcctttgc gagtttttag ccactccgct ttgaaataat
     6121 cattcattat tgtccccttt cttctttttc agtaaatact taactacgct atagatcatt
     6181 acgcagtaaa taaggtataa agtataattt aaaggcacgc ttttgtccca agaaaaaata
     6241 taatctaaac tatcactgga atttaaaatc tttattctat atagtgctaa aaaactcgat
     6301 cctccaaacg gaaaaataag gttaatccac tttaaagtct gggaggtaat cataccgaaa
     6361 aaacctgata aaaatccaat tcctaaaaga atcccttgtt tttctaaaat tattgataaa
     6421 taaagaaaga gagtgattaa agtaaaactg gacatcgtta aacctactac ttgtaaaatc
     6481 agagtccaaa ttggaacttg gatatcatat cttagtacat ttagataaac aatcaagact
     6541 tggaaaatat tcaaaagtag aaagacagaa tttgtgaaaa tcaatttgcg agtaaatatt
     6601 ataattagat ttgtattatt tgcttcttga agtttaaatg tactaccttc tttttcatta
     6661 ccaacaatac gtgaaacaaa taggcaagtt gcaataggta aaaaaataga attagcttgt
     6721 aaattattaa agaacaatcc gatagtccgt aatttaggaa tatcaatact tcttgaggct
     6781 gctaacaatg accacgtcac tgctactaac atcataatga aagaaatcat aaaagatttc
     6841 gtacgcttac tttttaataa ttcaatctgt attgctttta tcatttcaaa cctccttagt
     6901 taaagagagg aaaatgtctt ctaaattctc gctttcccta acaactcgga aaatccgata
     6961 gtcattttca attaaataag tcactacatc tgctaatttg tcattatcaa tatttttaaa
     7021 cttaacatga cttgctgaag ctcctagcac ttcaacctgt ccgtaattaa ttaaactttg
     7081 aacaatatta ttttgcgaga aatccccgcc aatctcaatc caagtatttg attttattgc
     7141 ttcaatttcc ccttcataaa ccagtctccc atgatttata atgcctactc ggtcagctat
     7201 atgctcaatt tcggataaaa tatgacttga gataaatact gttagccctt tctccttagc
     7261 taattttaca attaactcgc gaatttcatg aattccagcc ggatcaagtc cattagtagg
     7321 ttcatctaat aacaagattt ttggtttttt aaccagagca aaagccaagg ctaaccgttg
     7381 cttcatgcct aaagagtagg ctttcacaag tttttttcgg ttattttcct ctgctaaacc
     7441 aaccaatgcc aaagtcggcc agatattact ttcatcaaaa cctaccattt tttgaaagac
     7501 tagtagattc tcgtaacctg ttaaatttgg ataataggag ggttcctcaa tcattgaacc
     7561 gattacactc aaataagcgt ggttcccctt tatatcttca ccatttataa gaatttctcc
     7621 tagtgttgga gaaactagtg acaaaatcat tttcattgtt gttgtttttc ctgcaccatt
     7681 cggtccaaga aaaccgtaaa tctcgccttc acgaaccgta atcttttcta aatctaccgt
     7741 agtaatatcc tgatagacct tagaaagttt tcttaattca atagcatttt tcatgttaat
     7801 aaccccataa taagaccctt caatgagtct cttcctttcc ttctattaca acattattgt
     7861 atctaagcaa cttaaagata acattaagaa aagagaaaca ttctcttaat ttttggaagt
     7921 aatgaaattt gtatagttaa catttgtttc cataagatgt tcatgagtat ctttaataac
     7981 cttaccagtt tcattatcaa taaaaataat agaatcaaca taattgacaa tatctaaatg
     8041 atgactaacg attaacatag ttctgtctga atatctattg ttttgtaaaa cattatcgta
     8101 aattttgttc ttactttgtt catctaaatt actgaaagcc tcgtcccaaa aaataattga
     8161 attttctttt aaaagtgatt ttgctatgag taacttctgg atttgtccac ctgataaatt
     8221 ttttccttgt tttaagagtc tagagtgaat cttatttggt aatcgtgcta taacttcatc
     8281 agctgttgta tcattcaata cttggtaaag tggagttaca tcatctaaag tccactctaa
     8341 gttttctaag acagtcccct ttctaggtgt catattttga agaacaactc ttagattgtc
     8401 tttgaatttt tcgatgccat attcaagaga tccatcatag cgtagcatac ctgctaacat
     8461 taatagtaaa gttgacttcc cgctaccaga tttacctaca atggcaatct tttctccttt
     8521 actgattgtt aaattcacat cactatagat tggtttatta ccataagaaa agttcaaatt
     8581 tttagttttg attaaataat cgtctgactg tgaactaggt acaacgatag gtgaagtatc
     8641 ttttaataaa tcactttgtt tttctgcata tacacccaat cgaattactt caaatactgc
     8701 tccttttact tgttcaattg ctgatatcaa taaagaaata ctagtttgat aaactaatag
     8761 atcaggaagg gataaattaa tataatcctt ataatatact gcgataacaa ttattgagga
     8821 tagactaatg tagttaaaaa tagttccaat aagttgtgaa agattttcaa ttttaagaat
     8881 ctgcgaatac ttcttagtga cttgattatt ttgctccatc caggaatgga aaacagtttt
     8941 ctctcttctc attattttta tatagtcaat gtcatcaaga tctgtttgta actctgagtt
     9001 aaaatcaatt aagtactgta aatatgtctg attatactcg ttttgcctat gatacaatag
     9061 agtagagatt atactatatg aagcaatcat caagattaat atcaccgaca acttaataga
     9121 tatagtcatc agatatgcaa agataataat agctgaaatc aaacttacac atgatggaat
     9181 aatttttaaa gtaacattgt ccctaagtgt tgatttaaaa ctaatttttt cagatactcc
     9241 cccacttaga tgatttctaa aataaagtaa aggtttttgt aataatcttt gaaacaactc
     9301 tttactgtaa tatttatcaa agtctgtatt atatctatct aatgcaccat tctttataaa
     9361 ataacctaat aattgaaaaa ttaatactgc acctaaaagg aataagctga taccaaactt
     9421 gaaatcttca gctaacattt gtcttaaaat gactgagaac agtaaaacac taacttgaat
     9481 aaacaggagt gacaacaaga ataatgcaat cggttttaat tgtaaggtct gtttgaaata
     9541 cttccaaaag attttcttat atgtttgggg gtgaaaatta tttcttttgt taactgacac
     9601 catagtttcc gagtagtgag ttaaaaattc atcacggcta tacttaatac gaccaatggc
     9661 tgggtcaact ataactgttt tatttgacgt aattttttca agaaccacaa aatgatcatt
     9721 attccaatga agaatcattc tttgcttctt ttctccgtat acttttagta attcatcaaa
     9781 agaggcatga taagcattta ttttcacccc aaatctgtca cttagtgaca aaagatatga
     9841 gacatttaga ccatctgcag gcaatgtatc tttatcataa atttcatata atggaacttt
     9901 atgtcctaaa tcattaagta acattgtata acaagctaag agacaatcct cctcattgtt
     9961 ttgcaaaata atattcatat ctcatattcc tttctatctc ttagaaattg ggaatcaaca
    10021 catctaggga atcatcaccc ttcatgtact ttactgtaga aaataatatt cctgacacac
    10081 ctgtcattaa cccataaaca ttatattttg tattaaaact acacatccag ccgttttcca
    10141 ggccaaaaga atgcagtttt ctatactctc tatccaaaat ttcttttaac ttctctgaat
    10201 cagctcctgt taaatatgat tggtagtaag taagtgccag caaatttcca ctggttccat
    10261 ggcaaagtga aaagtttgtc atatcaaaac caatttcaag aatctgttta gcagcatgct
    10321 tcatatcatt ctctaattct atccgttcag aatgagaaag aaggctatat tcatcatcta
    10381 gttttaactg tgctaacctt gcaactaata ctcctgttga accatgacac cagttggcac
    10441 tagtcgagga atttcttttg tctatccagc cgttttccaa tttttgatgt ttatcaaaca
    10501 tttttgcttt atgaaataaa tttagtgcct caggactttc taactttcca gctaaataaa
    10561 gtaacgctat ttcaactcct aaattaccat gtgcaagact aacattattc gactctaact
    10621 tatcccaact aataaaatcc ttttgaacaa ttgccaactc tttaagtttg tctagtgcct
    10681 gagtaagatt atctatctta atatccgaat ttctcaaagc agtgatttca ttaggaaaac
    10741 ttgatagaaa atcagcactt aaaacatcta catccaatgt atatttgaga ttattataat
    10801 tcatgataga attttgaatc tcttgtcctg taacaacact aattcgtttt aaagctgagt
    10861 aaattcccag cttccccaca aaaaaagaat gatttggtaa tttcatatag gaattagata
    10921 atacagaaaa aattcgtttt agacattctt taacccttct ttgtcttcct gagtctagaa
    10981 aatcataagc ctctgataaa gaaattgcta ttccagacaa accttcataa agagagtcat
    11041 ccatcggaac taactcaaaa gcatcataat ctgtaacttt caaggtgagc cagtttgtac
    11101 tatcgtcttt tagagagttg ctttcatttt ccaaaataat atcaactaga gtatcaatac
    11161 cagtttttat tatattttca ctgctactaa ccttctcaaa tttttgatat gcctcttgaa
    11221 gttccgtact atataaagct ttaggagttt tgatagaaaa ctcaattaat tcaatttgct
    11281 catttatgat ttcttcactc aatttttcta atttattgat tgcttcgctt aaagcagaac
    11341 tttcaaggtt ccaaataatc atgttttcat cctttatatc acaactatca atatttgagt
    11401 aaaaataagg gatatccata tttaaaagct gtttcttttc tgatagacat aaactacgac
    11461 tattttgttc agacaattta ttggccattg tttcaaataa aatctcggat tgctcacaat
    11521 aaacaggaga aactagcaat tggcgcacta agctataatc tcttgtattt ctgaacaaaa
    11581 ttctagtctt tatatcatta tgcttaatat aaagcttctt taaaaaatct tgtgaattca
    11641 tgaaaaagta gctgacttca cggaaccctt ctttgatata ttcaacataa tcttcagcat
    11701 taagaaattc tttcattccc ttcgaatcaa taaagtaagg caaatgatcc tggttttctg
    11761 ttttaaactt ttgtttttca acatgaatat catctcggtt atgattgatg acgatttttg
    11821 cctctccaat taaggtgcct cctagaacac cactagtatc tcctccaaaa actttaccag
    11881 cttcagaaac aggaagcaaa cctgttgata atatcgaatt tctactatta ttaattatct
    11941 ccaatgttga ctcgttattt gcaacagttt gataggggct aactgaaaaa actgtctcaa
    12001 catcaactaa cttaggagaa aagcttgtag aaatcagatt ttcaaaatgc aaatcagaga
    12061 tattcaatat gtaagaatat gataataagt aacccatcct acgataaaat tcctttgcat
    12121 cctcctcggt tcttaacgga gaacttgata caaatttttc ccaaaaatac tctcctttat
    12181 ctaaaaaatc agggataaag tctatatctt tctgtaagaa tttaccaact tctatattca
    12241 gttcatgcaa gagaacattg ggatttgatg attttttctt aaaaactact ttttgttctt
    12301 cataactcaa aatgcagact ccacaaccat tgtgaatatc tccagttatt ttgattttga
    12361 cttcactaat ttttggagtc tgagcttcac tatagatata gcctgtctct ctcaactctt
    12421 tgaaatctaa agtaaatctt tcctttacaa aattaattaa ttccaaacat ttcttgatag
    12481 tactcattac acgctgatta atagaaggga aacgtctatc aatttcttca aaaattaagc
    12541 cattctgaca tagtacatta ttaaagtatt catagcgtga ctctggagaa tctccaatta
    12601 ggtttttctc aattcttttt tcatttatta ggtaaataag agtggaacga taataatcag
    12661 aaatttcatc ttcaacatcc ttaatcagct cactactttc atttagcaat tctgggaaat
    12721 tattttcaat aactactttt gggaatctat caaattggct atataacagt tcttttggat
    12781 tcatattctt tactcctaaa catattaaca acaagtaaaa attgcctgta aactattcca
    12841 acgacattca gctgaaattg tattgacacc atgccctctt cctcccaaaa ggttatccaa
    12901 ttcctcaatc tgaaattctt gtaacgcatt caaagcacct aggcacattt tttcttccat
    12961 aattctttac ctcatttata tgacatcgag tagaactcga aatttgtttt ctttatacat
    13021 tgattttaaa tttgttacat aaagacaata ttaaggaaaa ctaaagttaa attaaatttt
    13081 ctacctatgt caatgcaaat aaaaaaagag gtccccctct ttttttatgt aacatcaaag
    13141 acacctgaac agtagagttt tatgaacaac aagtagcaag gaatgcccat gtattcaaat
    13201 gacactcatg agaaattgtc ttaaatacac cgtttttccc agcaccgata atttggtcca
    13261 actcctcaag actaacttct tgaatagagt taataatttc atgttctttg gtcataacga
    13321 ttttctcctt atattttatc taatattatg agcaacaagt agcaaggaat gcccatgtat
    13381 tcaaatgaca ctcatgagaa attgttttaa acacaccatt ttttccagca ccgataattt
    13441 gatcgagttc ttcaagacta acttcttgaa tagagttgat tacttcatta tttttttcca
    13501 ttttctatac ctcatttaac tttcttcaga aggataggtg ccttcctctt tgttacaacc
    13561 ttattttaag atgataactt taagacagaa taaagaaaac ataaatttaa ttttaagatt
    13621 atacaacaca agtcctactt attctcttat atctataatc tttatggtat aattttatta
    13681 cactttagga ggtattgtat gaattttgag tctcaattat tgaataaacg catattgatt
    13741 gtcgacgatg atgtcgcact tagcaaatca attaaagagg tacttatcag tcgggatttc
    13801 aagaatatca gctgtgctta tagtataagc gaaggaattg atatcttctc agtttctaaa
    13861 attgatctca ttattttaga tgttatgcta ccagatggag aagggcactt acttgcaaaa
    13921 tacattagga aatattcaga tgtgccaatt ctctttttaa cagccaaaaa caatcctgat
    13981 gatgaaattc gaggacttga atccggaggg gatgattatg ttacgaagcc atttcttccc
    14041 aaatctttaa catatcgtat tattgcactg ttgagaaggg cttataaaga tgaatcggaa
    14101 ctaattgagc taacaaattg taccatagac ttaaacaatg caagtgttga aaaaaatggt
    14161 caacatttgt cactcactcc aacagaaata caaatcctac gaaaattatt ttcaaataaa
    14221 aattatattg catcaactga atcgatttgt gataccgttt ggggacttga gagccttggc
    14281 tacgaaaaat cacttatggt acatattcgc aatatcagag aaaaaatcga gataactcca
    14341 tctaagccaa atcatcttat tactgtaaaa gggcttggtt ataaactagt tatataaact
    14401 ataaggaata tagcatgaat attttcaaga aaaatatact aaaatttatc ctatcatttt
    14461 tctttattat aataattgac gtcatactgt taataactgc taccaattat atccgaagtc
    14521 agcagtctgc atctactata atcgaaactg tctcatctga aatcactcta tcttctaatg
    14581 gtaaatataa tgttagttct aaagctaaac aactcattga tgataaaaag ttatggataa
    14641 tgattattga caaagataat ggaaaagaaa aatttaatat taataaacct cagattatag
    14701 aaaatcaatt cgattttgca gatgctatac gattttctag attttaccta aaagactatc
    14761 ctgtatttac gcaaataaaa gataatgata tttacatcat tgcttttcca aaagacagta
    14821 taatacgtta tagtagtaat tatttcgaac taaatagagt tcaaattttt ccaatcctta
    14881 ttttgtctat catatttgca aactgtttgt tctgcctatt tctttacatt tattctgtta
    14941 cttttttaaa tcgtaacatt aaacctatca ttaacgcaat tactaaatta ccaaatggaa
    15001 ttaatactca ggtcaaatct gtacgagaat tagataaatt aacacttgct attaactcag
    15061 caaatcagca acttcgtgaa aacgaagaat tcaaggagaa ttggatttct ggaatagcac
    15121 atgatataaa gacaccactt tcagtaattg tatctaacac ttccttagcc attgaaaaaa
    15181 caaatgatga cgaattcctt aaacatttga aacccacctt agttgaaagt cactacattc
    15241 aaaatctcct aaacgattta aatatatttg ctcgattaac aaacggaaac ttaaaactaa
    15301 accatgagat tgttgatata atccctttct tcaaagaaat aatcattcag attatcaatc
    15361 aagaaatttg ggaagacttc aattttgaat tcattcctga ttctaaacta ttaggtaaga
    15421 aaatgtatat tgaaaaagct ctcatttcta gagttgttca taacctaatt tataattcag
    15481 tacttcataa tcattctggt tgcgacatta aaatcatttt agaatatcta cctgaagatt
    15541 gtttttcgat tactattcgt gataatggta taggaacttc tcctgaaaga ctaaaaaata
    15601 tcaataagat tgaagaattt aattttgata tgtcaggcgt tcgaaggagt ggtatgggat
    15661 tgaaaatttc taaacaaatt attgatttac atgatggaaa catgataatt acaagtacac
    15721 aagggcagta cttccaaaca gtaattaccc tccctattga atcactaaac acttaacaaa
    15781 attttttgat aaagcagaga ttaaaatccg aaacataagt aaaaaataat gactttagct
    15841 ttctgttatt cagaatattt attttttagg ctctttcttc acgattgcaa atattattat
    15901 cggagataat atcaactatg aaaaaatttt taaaaatcat tatttagtat ttggtgtgat
    15961 agacactact gcaaataaat cactaagatc tattaaaaag caagtctatt cctatctaga
    16021 tgatctctat cagtaagagg aagttcaaga gtattaagca tttgaacaaa ttcctcaagt
    16081 tcactaacct tcccctcgta ttcatctaga cgttctgtta aagaaatttg taactgttct
    16141 atttctcgct ctacttggtc aactttaata gttaatggaa tattcgtctt agtcaggtta
    16201 tacctagcta gccttttacc ctctttatta tcactttcta gattgataaa cacttccgcc
    16261 atcttgttta aggtggcgat tttttcttgg atttcctcta tcttcatgtc tagtgtggct
    16321 atttcttgga ccagctggtc cttggtttca agaaaggttt ggtcaggagt atgaatttcc
    16381 attagtagat ttatcttttc aaccttctct ttcaatgttt caagtgttac tcgttttcga
    16441 tatggaagtg gatgtatact ataaaagtag acaaaacttt gtgtgttaca atctgtttta
    16501 aaagacacaa aaacgaaagg acaacctatg tcaacagtta aacgctacga tgaagaattt
    16561 aaacaatccc ttgtcaacct ttatcaaact ggaaaaactc agtctgaact ctgtaaagac
    16621 tatggggtat ccgcttctgc gcttgcaaaa tggatcaaac agtattctca agtcaaactc
    16681 gaagataatt ctgtacttac tgccaagcaa atacaagagc tacaaaaacg taatgcgcag
    16741 cttgaagagg agaaccttat cctaaaaaaa gcaagtgcca tattcatgca aaacttaaag
    16801 taagactcct cgctgtctat cggttacgct ttgaacacga cacaacaacc ttgtgtcgtg
    16861 ttttacgtgt caatcgctcc acttactata aatttctaaa acataagccc tccaaaagag
    16921 aattggataa tcaaatttat aaaaaacaaa tacttgagat ttataccaaa gcgaacaaaa
    16981 gacttggtgt gaagtctatc aaagtcattc ttcaaagaga ctacgacaca aaaatctctg
    17041 aaggaagaat ttaccgtctg atgaagaata tggcgcttcc taaaatggct accgttaagc
    17101 caaaaacagc tcttaaaagg actcaaaaaa cgtatcctca aaacttactc aaccagaaat
    17161 ttaatcctga caaaccaaat caagtatggt ctactgactt cacctatatt tctattggat
    17221 ataagaaata tgtctatctc tgcgcaatac ttgatctcta ttctagaaaa tgtattgctt
    17281 ggagactgag tcatcatatg gatgcaaagt tagcatgtga cactctagaa ttagctctta
    17341 ataaaagaaa gattgaagga acacttctct ttcattccga ccaagggtca caatttaagg
    17401 ccagggaatt gagaaaaata attgatgaca acactatcat gcattctttt tctaaacctg
    17461 gatatcctta tgataatgcc gtaacggaag catttttcaa gtatttaaag catagacaaa
    17521 tcaaccgaaa aaagtatcaa aatatcaaac aggttcaatt agactgcttt gaatacattg
    17581 agaattttta taacaattac aacccacata cggctaatct aggactaaac cctaatcaga
    17641 aagaagaaaa ttagtttaac gtaataaaat aacacggttt tctgtctact tatttgacat
    17701 tagtccaaaa tacatcctaa tggtgtcgct ttttttattt cactagacat tcgttctagt
    17761 ttaggatata agaaggtctc aaattttttt caggatgttt attccaaaca tccaatcacc
    17821 tttctatata actgttcatt tagtggtata cacaaacaga aatactccgt ttctagtttc
    17881 atagaagacg gagtattttt tagtagagac gtctggattg atagatagtt ggtatatagc
    17941 tcatccctac taggctttca ttatagacta tggtgggttt ccttgacaac ccctttatca
    18001 aaatcgttga caacaatatt tgattattat tctaaatgac agtatacatc aactatcaag
    18061 tatgctttta attttatttt ttaaagctac agatgaaaat ctgtattcca tacttccatc
    18121 taatcgaaca ataatataat gatgtctcga atataattca tgtttaaaaa actttttgat
    18181 ttttttataa ggaaactcaa aaacggaaca atgataccca cttaatttat ttgctaattc
    18241 aagacaattc ttatagattt tcacatctat ttttcaacta atatcattat tctatcttca
    18301 atttcatact caatctcttg tgataaaaca gtggttccta ttcccatgca aactcctaat
    18361 acgtttactt tattaaattt agaaaccata tcatcaattc taccaccatc agcaatatca
    18421 aatatgtcac ctgacttagt tcgtatgaag attttatagt tcatacttga ataatgtcct
    18481 gttccatata aattagataa tgaaaagtaa atgcaatcta ctggtaaaaa gttttttaca
    18541 tactcataca agtctaaaac ttttataaat tcctgtttca ccagtttgtt acttattttt
    18601 gaaataagac taattaagag ttccatattt attttatctt tttcataaag acattttatg
    18661 atttctatgt cattattaca caaatattta cccaatattg cttcaattga aatatcttca
    18721 aatcttaact ttttagataa atctttctcc aaaacatcaa atatattttt gttagacagt
    18781 tgaataaatt ctactttaat tcctttaaac tcatccacat tctcgccact agtcgtgcga
    18841 ccaaagaggt aggaaaagtc ctgaccttca taactgtttt ggggcttatc tctagccctt
    18901 tttcttcaaa ttaaatcaag tagtcccata agccctcctt attttggggt acaaaaaaag
    18961 cacccccttt gaagtgcttt cggtatattt ctttcaaagt aatcaacagt ctttcttaca
    19021 aaacctagta ttctcattct gtcaattcct taaatgcgtc aagatgtcgt gataatactg
    19081 aagtcgcaat ctcatctaac cttgcttgtt caacaactgt tgtcatctgc tcatcaccaa
    19141 agttccatca gttgatttat aaaggttaaa ctcctgattc tcttgaatgc caaatgggtc
    19201 aggtatcgga ggatagatgt catcaccaat ttgtatcgtc tttacgagtt ccatacatca
    19261 ctctccctta ctttaccaat tattcatatg acgtgatcca tagacgaccg caacaattat
    19321 aacttcatct tccagaacat gatatacaat gcgatatttt tttcaatcag ctgtctgaag
    19381 gtatagcctt ttccaatcag atcctcaatg atggcacaac gttcaggaaa aatggatagt
    19441 gataacattc cttgggataa cctctcaaga agattatccg ctgcctgtgg tgcacagagt
    19501 tcatcacgaa catagtgata gatgttcagc aaatctgctt tagcatcatc cgacatggtg
    19561 acctgatatt ctttcattaa gcattttcct tcaattgaaa tagaaattct ctgacatcct
    19621 gacggttgcc agttttcgca tcttcaaagc tggtgataag cttatcataa aacttctcct
    19681 gactcatgta atcaacatta actcgttgag gcgcttcagg tagagaaaca tcaaatggga
    19741 tacccccagt caaaataatc tgattcaaaa acatatcaat cgcagttgac ataggaatac
    19801 ctaagcgttt caaaatatca tctgccgcac tttttactga atcatcaact cgtaaattca
    19861 aagttcccgt tttagccatg gttatcctcc ttttttgtaa cgacattgta tcacattttg
    19921 ggagttgact caactaaaaa ctcaatatcc ctcgctcatc atagacgcta gcttcatcac
    19981 cttggcggcg aatgcaacgg tcaagaacca ggataagacc tacaataccg tcaatcttct
    20041 caacagattt ttccttatct ggcttgatgt tgcctgcagg agcttgtccc atcaccacgt
    20101 tttgtcccat ccatttaagg actgggtgac cactatgtta gattttccct tccatcatga
    20161 gtttatagag ttccttggac ggtggactca tatccttata accctgccca aaaggcacca
    20221 tggtcaagtc gacaccgcaa ttccaaggta tcttctagta accatcagag agaagacagg
    20281 gattgtaaaa tcaaccactg tgcaaaatac tgcgttcact acccagtcga atcagctcaa
    20341 aaaacaatac gggcagttct tgttaacaga atctaataac tgttgtgcat gcccaggctg
    20401 tgatagacca ctcattctaa ccagtggcaa cttagcagca gaaaattacg aggtttcagc
    20461 cattgaaaaa gataaggacg ctgaaccact gaatctgata gccctctgcc cagattgttt
    20521 tttaacctat caagcagata gtcgcaaaaa aattgtaaca gctctaaaaa atgttaaaaa
    20581 gattctagtc tctgcacata acagccaaca agcgatttct gatatgaagt tagacagtgg
    20641 aattgtttca gttttgacta gtctcaataa actaaaatgt gatgaatatg atatctccta
    20701 tgactcgaag caattgactg ataagatatc acctgagaac aatcgtacgc tttatcaatt
    20761 ggttaaaaac caagttattg ataactactt aaccattcaa aaaatcatcg taaatttgga
    20821 caaacaagga aaaattgatt acgaggaaat ccaatatcaa acgcgatcga tgtataaaaa
    20881 gttaaaagca gccaagcata ataatctggc tattttcaat actatttcgg aaaaactcca
    20941 taaagctaca ctacaggaca tctacttctg tcagacgatt gtctcttact ttatccaaaa
    21001 atgcgaggta cttgaataat gcaattacca aataaacttt actcctatca aaaaagcacc
    21061 cttgcttatt tgcctagagt gctaaatgaa atcaaaagtg gaaactcaaa cgtcaaagat
    21121 atctttcacg ctatctcaga agagttggat gatcctacag atttcctatc tataatggat
    21181 tgcttgtatg cattgaacgc tattgaaatg tctaatgaag gagaagtaaa attatgctta
    21241 tagaaatgtg gtctccagta tttaagaaac acggagaaat tcgggaacca atctgcttcc
    21301 accatgggtt aaacgtgatt atggggatgg atttagctga taactctatc ggcaaatcct
    21361 cctcactatt agccattgat ttcatctttg gaggtaatag ctatctaaaa tcaattgcgg
    21421 ttaaaaaatt aggtgatcat cctatctatt tctgctttca atttgagaaa aagttttatt
    21481 tttcaagaga tacggccaac ccagatatca ttctagtgtg tgacaagagc tactctccaa
    21541 ccggtgaaac aatggatcta ggaatttttc ttaacagact taagaaacga tatcatttag
    21601 attctccaga gctatcattc cgattagcta tgagtggctt ctttaggatt gcaggaaaaa
    21661 gtaatcaaaa taccgatttc cccttacaag tttattcgag ccaaaaatct tctgaatcta
    21721 ttactactct catccaactg tttaatttgt atgataacat tgcacgatac aaagcacgta
    21781 tgaaagataa gagcgaccag ttaacaactt ttcgtaatgc tcgaaagtat gccttcatct
    21841 ccaacctggt tggcggtaaa aagcaatttg aagcaaatgt ctcagaaata aaaatattgg
    21901 aatatgattt agcacatctc caagatactc agcaagataa aattgactct gatgatattg
    21961 agaaaaatca acaaaaactc caacttagaa atactaagct ggagttagaa agcagtcttc
    22021 gggacaagca aagacgtctt aagctattgg acatcagtat cgaatttggc ttatatccta
    22081 ctgaatctga cttaacagag cttcaacaat acttcccaga tactaatctc aaaaaattat
    22141 atgaagttga agcttaccac aaaaaattgg aaactatttt agattccgaa ttctcaactg
    22201 aacgtgaatc cctaatagct gagatcgacg aattagagag tcaattaaca actctaaacc
    22261 aagaacttca agaactagga aacatcccaa atctttcaag tgagtactta gaaaactact
    22321 ctaaactaac agctacaatc aatgcactaa aagaacaaaa cgaggcctac ttaaaggagt
    22381 ctggtctatc caaagaaaaa tcagaagcgg acgctgactt gaaacgcagt acagaagata
    22441 tccttctaga tctagaagta aaaatcaaca gtaagatgcg tgaagtcaat aacattctat
    22501 atccagatat tcgcaaagct cctcaaatta acctcaatgc tcacaatagc tactccttct
    22561 atacaccaga tgatgatggt acaagaacta agttcaaagg gatgattgta ttcgacttag
    22621 taatgctcta ccttactaat ctgccagcac tcgcacacga ttcattactc ttgagtaatg
    22681 ttagctacca agcgactgaa gcacttttga agctgtatga ccagtcaaag tcattgaaca
    22741 aacaagtctt tttagccttc gataaagcca gctcttattc tcca
//
