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Overview
1.1
1.2
1.3
1.4

### Identified secondary metabolite regions using strictness 'relaxed'

NZ_LS483338.1

Region | Type | From | To | Most similar known cluster | Similarity
--- | --- | --- | --- | --- | ---
Region 1 | T3PKS | 1,050,125 | 1,091,300 |
Region 2 | LAP | 1,188,075 | 1,211,841 | streptolysin S | RiPP:LAP | 100%
Region 3 | lanthipeptide-class-ii | 1,289,900 | 1,312,683 | streptococcin A-FF22 | RiPP:Lanthipeptide | 100%
Region 4 | RiPP-like | 1,360,394 | 1,372,258 |

NZ_LS483338.1 - Region 1 - T3PKS
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 1,050,125 - 1,091,300 nt. (total: 41,176 nt) Show pHMM detection rules used
T3PKS: (Chal_sti_synt_C or Chal_sti_synt_N)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
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zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
MIBiG comparison
KnownClusterBlast
Pfam domains
TIGRFAM domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | T3PKS | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000286.1 |  | 0.18 | Polyketide | viguiepinol | Streptomyces sp. KO-3988
BGC0001521.1 |  | 0.17 | NRP | auriculamide | Herpetosiphon aurantiacus DSM 785
BGC0001591.1 |  | 0.16 | Other | fatty acid enol ester | uncultured bacterium CSLC2
BGC0001688.1 |  | 0.16 | Other | N-tetradecanoyl tyrosine | uncultured bacterium CSLC2
BGC0000626.1 |  | 0.15 | RiPP | thuricin | Bacillus thuringiensis
BGC0000668.1 |  | 0.15 | Terpene, Alkaloid | 12-epi-hapalindole C isonitrile, 12-epi-hapalindole E, 12-epi-fischerindole U isonitrile, fischerindole L, 12-epi-fischerindole I isonitrile, welwitindolinone A isonitrile, welwitindolinone B isothiocyanate, welwitindolinone C isothiocyanate, N-methylwelwitindolinone C isothiocyanate, N-methylwelwitinsolinone C isonitrile, 3-epi-welwitindolinone B isothiocyanate, 3-(Z-2'-isocyanoethenyl)-indole | Hapalosiphon welwitschii UTEX B 1830
BGC0001863.1 |  | 0.15 | RiPP, Terpene | bacillicn CER074 | Bacillus mycoides
BGC0000490.1 |  | 0.15 | RiPP | garvicin ML | Lactococcus garvieae DCC43
BGC0001222.1 |  | 0.15 | RiPP | acidocin B | Lactobacillus acidophilus
BGC0000491.1 |  | 0.15 | RiPP | gassericin A | Lactobacillus gasseri

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000286.1 |  | 0.49 | Polyketide | viguiepinol | Streptomyces sp. KO-3988
BGC0001521.1 |  | 0.49 | NRP | auriculamide | Herpetosiphon aurantiacus DSM 785
BGC0001591.1 |  | 0.46 | Other | fatty acid enol ester | uncultured bacterium CSLC2
BGC0001688.1 |  | 0.46 | Other | N-tetradecanoyl tyrosine | uncultured bacterium CSLC2
BGC0000626.1 |  | 0.46 | RiPP | thuricin | Bacillus thuringiensis
BGC0000668.1 |  | 0.46 | Terpene, Alkaloid | 12-epi-hapalindole C isonitrile, 12-epi-hapalindole E, 12-epi-fischerindole U isonitrile, fischerindole L, 12-epi-fischerindole I isonitrile, welwitindolinone A isonitrile, welwitindolinone B isothiocyanate, welwitindolinone C isothiocyanate, N-methylwelwitindolinone C isothiocyanate, N-methylwelwitinsolinone C isonitrile, 3-epi-welwitindolinone B isothiocyanate, 3-(Z-2'-isocyanoethenyl)-indole | Hapalosiphon welwitschii UTEX B 1830
BGC0001863.1 |  | 0.45 | RiPP, Terpene | bacillicn CER074 | Bacillus mycoides
BGC0000490.1 |  | 0.45 | RiPP | garvicin ML | Lactococcus garvieae DCC43
BGC0001222.1 |  | 0.45 | RiPP | acidocin B | Lactobacillus acidophilus
BGC0000491.1 |  | 0.45 | RiPP | gassericin A | Lactobacillus gasseri

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.

No matches found.

Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
NZ_LS483338.1 - Region 2 - LAP
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 1,188,075 - 1,211,841 nt. (total: 23,767 nt) Show pHMM detection rules used
LAP: ((((goadsporin_like or PF00881 or TIGR03605) and (YcaO or TIGR03882 or TIGR03604)) or TIGR03603 or TIGR03602) and not cyanobactin_synth)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
MIBiG comparison
KnownClusterBlast
Pfam domains
TIGRFAM domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | LAP | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000566.1 |  | 1.00 | RiPP | streptolysin S | Streptococcus pyogenes M1 GAS
BGC0001170.1 |  | 0.36 | RiPP | clostridiolysin S | Clostridium sporogenes ATCC 15579
BGC0000564.1 |  | 0.36 | RiPP | clostridiolysin S | Clostridium botulinum A str. ATCC 3502
BGC0000569.1 |  | 0.31 | RiPP | plantazolicin | Bacillus velezensis FZB42
BGC0001173.1 |  | 0.31 | RiPP | plantazolicin | Bacillus pumilus ATCC 7061
BGC0000568.1 |  | 0.27 | RiPP | microcin B17 | Escherichia coli
BGC0001171.1 |  | 0.21 | RiPP | listeriolysin S | Listeria monocytogenes serotype 4b str. F2365
BGC0000565.1 |  | 0.17 | RiPP | goadsporin | Streptomyces sp. TP-A0584
BGC0000643.1 |  | 0.17 | Terpene | carotenoid | Brevundimonas vesicularis
BGC0000634.1 |  | 0.16 | Terpene | carotenoid | Brevundimonas sp. SD212

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000566.1 |  | 1.00 | RiPP | streptolysin S | Streptococcus pyogenes M1 GAS
BGC0001170.1 |  | 0.68 | RiPP | clostridiolysin S | Clostridium sporogenes ATCC 15579
BGC0000564.1 |  | 0.68 | RiPP | clostridiolysin S | Clostridium botulinum A str. ATCC 3502
BGC0000569.1 |  | 0.64 | RiPP | plantazolicin | Bacillus velezensis FZB42
BGC0001173.1 |  | 0.64 | RiPP | plantazolicin | Bacillus pumilus ATCC 7061
BGC0000568.1 |  | 0.60 | RiPP | microcin B17 | Escherichia coli
BGC0001171.1 |  | 0.53 | RiPP | listeriolysin S | Listeria monocytogenes serotype 4b str. F2365
BGC0000565.1 |  | 0.48 | RiPP | goadsporin | Streptomyces sp. TP-A0584
BGC0000643.1 |  | 0.48 | Terpene | carotenoid | Brevundimonas vesicularis
BGC0000634.1 |  | 0.47 | Terpene | carotenoid | Brevundimonas sp. SD212

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.
Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
NZ_LS483338.1 - Region 3 - lanthipeptide-class-ii
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 1,289,900 - 1,312,683 nt. (total: 22,784 nt) Show pHMM detection rules used
lanthipeptide-class-ii: cds(LANC_like and DUF4135)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
MIBiG comparison
KnownClusterBlast
Lanthipeptides
Pfam domains
TIGRFAM domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | lanthipeptide-class-ii | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000557.1 |  | 0.86 | RiPP | streptococcin A-FF22 | Streptococcus pyogenes
BGC0001788.1 |  | 0.58 | RiPP | suicin 65 | Streptococcus suis
BGC0000550.1 |  | 0.50 | RiPP | salivaricin G32 | Streptococcus salivarius
BGC0000526.1 |  | 0.44 | RiPP | macedocin | Streptococcus macedonicus
BGC0000626.1 |  | 0.36 | RiPP | thuricin | Bacillus thuringiensis
BGC0000528.1 |  | 0.36 | RiPP | michiganin A | Clavibacter michiganensis subsp. michiganensis NCPPB 382
BGC0001787.1 |  | 0.36 | RiPP | suicin 3908 | Streptococcus suis
BGC0000547.1 |  | 0.35 | RiPP | salivaricin 9 | Streptococcus salivarius
BGC0000534.1 |  | 0.34 | RiPP | mutacin K8 | Streptococcus mutans
BGC0001579.1 |  | 0.33 | RiPP | duramycin | Streptomyces cinnamoneus

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000557.1 |  | 0.95 | RiPP | streptococcin A-FF22 | Streptococcus pyogenes
BGC0001788.1 |  | 0.83 | RiPP | suicin 65 | Streptococcus suis
BGC0000550.1 |  | 0.79 | RiPP | salivaricin G32 | Streptococcus salivarius
BGC0000526.1 |  | 0.75 | RiPP | macedocin | Streptococcus macedonicus
BGC0000626.1 |  | 0.69 | RiPP | thuricin | Bacillus thuringiensis
BGC0000528.1 |  | 0.69 | RiPP | michiganin A | Clavibacter michiganensis subsp. michiganensis NCPPB 382
BGC0001787.1 |  | 0.69 | RiPP | suicin 3908 | Streptococcus suis
BGC0000547.1 |  | 0.68 | RiPP | salivaricin 9 | Streptococcus salivarius
BGC0000534.1 |  | 0.67 | RiPP | mutacin K8 | Streptococcus mutans
BGC0001579.1 |  | 0.66 | RiPP | duramycin | Streptomyces cinnamoneus

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.
Lanthipeptide predictions
Lists the possible core peptides for each biosynthetic enzyme, including the predicted class. Each core peptide shows the leader and core peptide sequences, separated by a dash.

#### Lanthipeptide(s) for ctg1_1230 - Putative Class II

ctg1_1231 leader / core peptide
  MEEKMCLGALNALQEFQIEELDNLLGG - RGHGVNDhbIDhaAECRWNDhaLQAIFDhb C C
ctg1_1232 leader / core peptide
  MTKEHEIINSIQEVSLEELDQIIGA - GKNGVFKDhbIDhaHECHLNDhbWAFLADhb C C Dha
ctg1_1233 leader / core peptide
  MEKNNEVINSIQEVSLEELDQIIGA - GKNGVFKDhbIDhaHECHLNDhbWAFLADhb C C Dha
ctg1_1246 leader / core peptide
  MQLPNKLYSYQKSTLAYLPRVLNEIKSGNSNVKDIFHA - IDhaEELDDPDhbDFLDhaIMDCLYALNAIEMDhaNEGEVKLCL
allorf_1307948_1308163 leader / core peptide
  VKIYKNCLELANKLSG - YHC DhaVFEFPYKKIKKFFKHELYDhaRHHYIIVRLDGDhaMEYRFDha DhaVALKNKIKDhaILDDha

#### Legend:

Dha: Didehydroalanine
Dhb: Didehydrobutyrine
Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
Lanthipeptides
Core peptide predictions
Lists the possible core peptides in the region. Each core peptide lists the number of lanthionine bridges, possible molecular weights, and the scores for cleavage site prediction and RODEO.

ctg1_1231 - Class II
  Cleavage pHMM score: 3.80
  RODEO score: 0
  Monoisotopic mass: 2593.2 Da
  Molecular weight: 2594.9 Da
  Number of bridges: 3
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    2613.0 Da N = 1
ctg1_1232 - Class II
  Cleavage pHMM score: 5.20
  RODEO score: 0
  Monoisotopic mass: 2776.3 Da
  Molecular weight: 2778.2 Da
  Number of bridges: 3
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    2796.2 Da N = 1
    2814.2 Da N = 2
ctg1_1233 - Class II
  Cleavage pHMM score: 5.20
  RODEO score: 0
  Monoisotopic mass: 2776.3 Da
  Molecular weight: 2778.2 Da
  Number of bridges: 3
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    2796.2 Da N = 1
    2814.2 Da N = 2
ctg1_1246 - Class II
  Cleavage pHMM score: -7.00
  RODEO score: 0
  Monoisotopic mass: 3960.9 Da
  Molecular weight: 3963.5 Da
  Number of bridges: 2
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    3981.5 Da N = 1
    3999.5 Da N = 2
allorf_1307948_1308163 - Class II
  Cleavage pHMM score: -6.40
  RODEO score: 0
  Monoisotopic mass: 6598.5 Da
  Molecular weight: 6602.7 Da
  Number of bridges: 1
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    6620.7 Da N = 1
    6638.7 Da N = 2
    6656.7 Da N = 3
    6674.7 Da N = 4
    6692.8 Da N = 5
    6710.8 Da N = 6

NZ_LS483338.1 - Region 4 - RiPP-like
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 1,360,394 - 1,372,258 nt. (total: 11,865 nt) Show pHMM detection rules used
RiPP-like: (strepbact or Antimicrobial14 or Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or Lactococcin or Antimicrobial17 or Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or TIGR03975 or DUF692 or TIGR01193)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
MIBiG comparison
KnownClusterBlast
Pfam domains
TIGRFAM domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | RiPP-like | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000526.1 |  | 0.04 | RiPP | macedocin | Streptococcus macedonicus

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000526.1 |  | 0.20 | RiPP | macedocin | Streptococcus macedonicus

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.

No matches found.

Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names