LOCUS       NZ_CP020549.1           8989 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  NZ_CP020549.1 Streptococcus pneumoniae strain Hu17 chromosome.
ACCESSION   NZ_CP020549
VERSION     NZ_CP020549.1
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 6.1.1
            Run date     :: 2024-03-14 13:01:09
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 1842276
            Orig. end    :: 1851265
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     CDS             complement(1..1017)
                     /locus_tag="ctg1_1831"
                     /transl_table=11
                     /translation="MVKKIIGMVLALLSVTVVGVGVFAYTIYQQGTETLAKTYKKIGEE
                     TKVIEATEPLTILLMGVDTGNAERTETWVGRSDSMILMTVNPKTKKTTMMSLERDILTR
                     IESGNGQAHEAKLNSAYADGGAELAIETIQKMMNIHIDRYVMVNMRGLQKLVDAVGGIT
                     VNNILGFPISISDQEEFNTISIGVGEQHIGGEEALVYARMRYQDPEGDYGRQKRQREVI
                     QKVMEKALSLNSVGHYQEILKALSDNMQTNIDLSAKSIPNLLGYKDSFKTIETQQLQGE
                     GEILQGVSYQIVSRAHMLEMQNILRRSLGQEEVTQLETNAVLFEDLFGRAPVGDEDN"
     protocluster    1..8989
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[1846875:1847172](+)"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193)"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      4600..4896
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193)"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
     cand_cluster    1..8989
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193)"
                     /kind="single"
                     /product="RiPP-like"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..8989
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="RiPP-like"
                     /region_number="6"
                     /rules="(strepbact or Antimicrobial14 or Bacteriocin_IId or
                     BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or
                     Lactococcin or Antimicrobial17 or Lactococcin_972 or
                     Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or
                     TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or
                     TIGR03975 or DUF692 or TIGR01193)"
                     /tool="antismash"
     aSDomain        complement(328..795)
                     /aSDomain="TIGR00350"
                     /aSTool="tigrfam"
                     /description="lytR_cpsA_psr: cell envelope-related function
                     transcriptional attenuator common domain"
                     /detection="hmmscan"
                     /domain_id="TIGRFam_ctg1_1831_0049"
                     /evalue="2.20E-46"
                     /identifier="TIGR00350"
                     /label="ctg1_1831"
                     /locus_tag="ctg1_1831"
                     /protein_end="230"
                     /protein_start="74"
                     /score="155.9"
                     /tool="antismash"
                     /translation="GRSDSMILMTVNPKTKKTTMMSLERDILTRIESGNGQAHEAKLNS
                     AYADGGAELAIETIQKMMNIHIDRYVMVNMRGLQKLVDAVGGITVNNILGFPISISDQE
                     EFNTISIGVGEQHIGGEEALVYARMRYQDPEGDYGRQKRQREVIQKVMEKAL"
     PFAM_domain     complement(331..792)
                     /aSDomain="LytR_cpsA_psr"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF03816.16"
                     /description="LytR_cpsA_psr family"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_1831_0111"
                     /evalue="1.60E-47"
                     /label="ctg1_1831"
                     /locus_tag="ctg1_1831"
                     /protein_end="229"
                     /protein_start="75"
                     /score="161.6"
                     /tool="antismash"
                     /translation="RSDSMILMTVNPKTKKTTMMSLERDILTRIESGNGQAHEAKLNSA
                     YADGGAELAIETIQKMMNIHIDRYVMVNMRGLQKLVDAVGGITVNNILGFPISISDQEE
                     FNTISIGVGEQHIGGEEALVYARMRYQDPEGDYGRQKRQREVIQKVMEKA"
     CDS             complement(1025..1543)
                     /locus_tag="ctg1_1832"
                     /transl_table=11
                     /translation="MEYELLIREAEPKDAAELVAFLNRVSLETDFTSLDGDGILLTSEE
                     MEIFLNKQASSDNQITLLAFLNGKIAGIVNITADQRKRVRHIGDLFIVIGKRYWNNGLG
                     SLLLEEAIEWAQASGILRRLQLTVQTRNQAAVHLYQKHGFVIEGSQERGAYIEEGKFID
                     VYLMGKLID"
     PFAM_domain     complement(1112..1414)
                     /aSDomain="Acetyltransf_1"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00583.27"
                     /description="Acetyltransferase (GNAT) family"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_1832_0112"
                     /evalue="1.60E-17"
                     /label="ctg1_1832"
                     /locus_tag="ctg1_1832"
                     /protein_end="144"
                     /protein_start="43"
                     /score="63.9"
                     /tool="antismash"
                     /translation="EEMEIFLNKQASSDNQITLLAFLNGKIAGIVNITADQRKRVRHIG
                     DLFIVIGKRYWNNGLGSLLLEEAIEWAQASGILRRLQLTVQTRNQAAVHLYQKHGF"
     CDS             complement(1533..1976)
                     /locus_tag="ctg1_1833"
                     /transl_table=11
                     /translation="MYTKNEEELQALGERLGHLLAKNDVLILIGELGAGKTTFTKGLAK
                     GLQISQMIKSPTYTIVREYEGRLPLYHLDVYRIEGDADSIDLDEFIFGGGVTVIEWGNL
                     LGDALPDAYLELEILKEADGRRLNFQAKGLRAEKLLEELQYGV"
     aSDomain        complement(1584..1967)
                     /aSDomain="TIGR00150"
                     /aSTool="tigrfam"
                     /description="T6A_YjeE: tRNA threonylcarbamoyl adenosine
                     modification protein YjeE"
                     /detection="hmmscan"
                     /domain_id="TIGRFam_ctg1_1833_0050"
                     /evalue="3.00E-33"
                     /identifier="TIGR00150"
                     /label="ctg1_1833"
                     /locus_tag="ctg1_1833"
                     /protein_end="131"
                     /protein_start="3"
                     /score="112.5"
                     /tool="antismash"
                     /translation="KNEEELQALGERLGHLLAKNDVLILIGELGAGKTTFTKGLAKGLQ
                     ISQMIKSPTYTIVREYEGRLPLYHLDVYRIEGDADSIDLDEFIFGGGVTVIEWGNLLGD
                     ALPDAYLELEILKEADGRRLNFQA"
     PFAM_domain     complement(1602..1967)
                     /aSDomain="TsaE"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF02367.19"
                     /description="Threonylcarbamoyl adenosine biosynthesis
                     protein TsaE"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_1833_0113"
                     /evalue="5.80E-36"
                     /label="ctg1_1833"
                     /locus_tag="ctg1_1833"
                     /protein_end="125"
                     /protein_start="3"
                     /score="123.4"
                     /tool="antismash"
                     /translation="KNEEELQALGERLGHLLAKNDVLILIGELGAGKTTFTKGLAKGLQ
                     ISQMIKSPTYTIVREYEGRLPLYHLDVYRIEGDADSIDLDEFIFGGGVTVIEWGNLLGD
                     ALPDAYLELEILKEADGR"
     CDS             complement(2062..2682)
                     /locus_tag="ctg1_1834"
                     /transl_table=11
                     /translation="MKSMRILFLLALIQISLSSCFLWKECILSFKQSTAFFIGSMVFVS
                     GICAGVNYLYTRKQEVHSVLASKKSVKLFYSMLLLINLLGAVLVLSDNLFIKNTLQQEL
                     VDFLLPSFFFLFGLDLLIFLPLKKYVRDFLAMLDRKKTVLVTILATLLFLRNPMTIVSL
                     LIYTGLGLFFAAYLVPNSVKKEVSFYGHIFRDLVLVIVTLIFF"
     CDS             complement(3065..3928)
                     /locus_tag="ctg1_1835"
                     /transl_table=11
                     /translation="MNTLAEKFRLKRKELRLSQQTLAEGICEQSQISKIERGHFIPSAD
                     LLFKLSQRLEVPLDYFFNEQIEIKSNLSNFKQLSARLLDDRNYDNLEYIYRIEIERSTF
                     LTLEDRTYLEWIKAIIDFYQYDSKCEAISSLENILLKVSSNTLIYLKALNTLSNFYSLV
                     GREQEYEANYSHLIELYQTKNLDHQEFLFGYIRVRYNYAHYLVSKEKYNEAIQEALETI
                     ELCKQRQTSYQLAPLLILVGNAGAKFLDREQVKNYYIEARELCKIYNNPLMLMKIENYL
                     KELDTV"
     PFAM_domain     complement(3746..3904)
                     /aSDomain="HTH_3"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF01381.24"
                     /description="Helix-turn-helix"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_1835_0114"
                     /evalue="2.30E-12"
                     /label="ctg1_1835"
                     /locus_tag="ctg1_1835"
                     /protein_end="61"
                     /protein_start="8"
                     /score="46.8"
                     /tool="antismash"
                     /translation="RLKRKELRLSQQTLAEGICEQSQISKIERGHFIPSADLLFKLSQR
                     LEVPLDYF"
     CDS             4600..4896
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: Lactococcin_972"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg1_1836"
                     /sec_met_domain="Lactococcin_972 (E-value: 9.6e-07,
                     bitscore: 26.3, seeds: 6, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLKFRKVVASSLAVLAFSLALPVLAVSHRGGEWTYGGHHDPYNWG
                     AFSNYYHGSQYHWAYVGSNERDNQKTVYAGAHSAAYAFVNTNLGERITFDAGW"
     aSDomain        4630..4881
                     /aSDomain="TIGR01653"
                     /aSTool="tigrfam"
                     /description="lactococcin_972: bacteriocin, lactococcin 972
                     family"
                     /detection="hmmscan"
                     /domain_id="TIGRFam_ctg1_1836_0051"
                     /evalue="2.10E-08"
                     /identifier="TIGR01653"
                     /label="ctg1_1836"
                     /locus_tag="ctg1_1836"
                     /protein_end="94"
                     /protein_start="10"
                     /score="32.3"
                     /tool="antismash"
                     /translation="SLAVLAFSLALPVLAVSHRGGEWTYGGHHDPYNWGAFSNYYHGSQ
                     YHWAYVGSNERDNQKTVYAGAHSAAYAFVNTNLGERITF"
     PFAM_domain     4687..4845
                     /aSDomain="Lactococcin_972"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF09683.12"
                     /description="Bacteriocin (Lactococcin_972)"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_1836_0115"
                     /evalue="2.30E-08"
                     /label="ctg1_1836"
                     /locus_tag="ctg1_1836"
                     /protein_end="82"
                     /protein_start="29"
                     /score="34.5"
                     /tool="antismash"
                     /translation="GGEWTYGGHHDPYNWGAFSNYYHGSQYHWAYVGSNERDNQKTVYA
                     GAHSAAYA"
     aSDomain        4999..7008
                     /aSDomain="TIGR01654"
                     /aSTool="tigrfam"
                     /description="bact_immun_7tm: bacteriocin-associated
                     integral membrane protein"
                     /detection="hmmscan"
                     /domain_id="TIGRFam_ctg1_1837_0052"
                     /evalue="3.00E-69"
                     /identifier="TIGR01654"
                     /label="ctg1_1837"
                     /locus_tag="ctg1_1837"
                     /protein_end="670"
                     /protein_start="0"
                     /score="232.1"
                     /tool="antismash"
                     /translation="MKKLFILISNLLASLFFVWVFTIWTDTYVSHYYPNVVVHDSSPET
                     TFQHVATRLEKLAEETDSFIAIQHQDPNSEGTTVFSYTTFGDGKLPDGLQEKKLEDAQS
                     SSVETNYFVFDGHLDIHLLREELSQLGLTNMHLTIPSKLSTLMAIFSNGFQLISLLIFI
                     LTFGALTLISQISQLRSSGIRLISGEKRWSIFLRPVGEDLKGIAVGFSLAGVLTILMQK
                     ILSLPTQSLMTIGAGLLSYNLILLSISLFFAQLFAVGIKKIHLMQIIKGQVPVRGIISL
                     ILIGQLLAIIIVTLGIGSSLKYSQAWQQHRIGQEAWSQERQLITLSISREGTSPGFDEQ
                     AQRKLRTWYQLMDLAVSEQKAFLSRHQLIDRTLQNGMASSKNFITSTEWHDYSPNGNVL
                     IVTPQYLERQNIPVDTTIEQKMNHLDVGEFVLLLPEHLRSEEDHYKSVFEDDLTSRMSS
                     QDERQQMTATVGYLESGQDRFVYNTTPISYQQFLKDPIIIVITPQSTGPQSILFWIDAV
                     QNYVLFNQLSDAQELIQRQGIENWVSEMQTGYHNYITLLDNIQRERWVMLAGAVLGIAT
                     SILLFNTMNRLYFEEFRRAIFIKRIAGLRFLEIHRTYLFAQLGVFLLGFVASVFLQVEI
                     GVAFLVLLLFTGLSLLQLHVQMQKENKMSMLVLKG"
     CDS             4999..7014
                     /locus_tag="ctg1_1837"
                     /transl_table=11
                     /translation="MKKLFILISNLLASLFFVWVFTIWTDTYVSHYYPNVVVHDSSPET
                     TFQHVATRLEKLAEETDSFIAIQHQDPNSEGTTVFSYTTFGDGKLPDGLQEKKLEDAQS
                     SSVETNYFVFDGHLDIHLLREELSQLGLTNMHLTIPSKLSTLMAIFSNGFQLISLLIFI
                     LTFGALTLISQISQLRSSGIRLISGEKRWSIFLRPVGEDLKGIAVGFSLAGVLTILMQK
                     ILSLPTQSLMTIGAGLLSYNLILLSISLFFAQLFAVGIKKIHLMQIIKGQVPVRGIISL
                     ILIGQLLAIIIVTLGIGSSLKYSQAWQQHRIGQEAWSQERQLITLSISREGTSPGFDEQ
                     AQRKLRTWYQLMDLAVSEQKAFLSRHQLIDRTLQNGMASSKNFITSTEWHDYSPNGNVL
                     IVTPQYLERQNIPVDTTIEQKMNHLDVGEFVLLLPEHLRSEEDHYKSVFEDDLTSRMSS
                     QDERQQMTATVGYLESGQDRFVYNTTPISYQQFLKDPIIIVITPQSTGPQSILFWIDAV
                     QNYVLFNQLSDAQELIQRQGIENWVSEMQTGYHNYITLLDNIQRERWVMLAGAVLGIAT
                     SILLFNTMNRLYFEEFRRAIFIKRIAGLRFLEIHRTYLFAQLGVFLLGFVASVFLQVEI
                     GVAFLVLLLFTGLSLLQLHVQMQKENKMSMLVLKGG"
     PFAM_domain     6709..7008
                     /aSDomain="DUF1430"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF07242.13"
                     /description="Protein of unknown function (DUF1430)"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_1837_0116"
                     /evalue="7.00E-26"
                     /label="ctg1_1837"
                     /locus_tag="ctg1_1837"
                     /protein_end="670"
                     /protein_start="570"
                     /score="90.5"
                     /tool="antismash"
                     /translation="VLGIATSILLFNTMNRLYFEEFRRAIFIKRIAGLRFLEIHRTYLF
                     AQLGVFLLGFVASVFLQVEIGVAFLVLLLFTGLSLLQLHVQMQKENKMSMLVLKG"
     CDS             7016..7648
                     /gene_functions="transport (smcogs) SMCOG1000:ABC
                     transporter ATP-binding protein (Score: 172.4; E-value:
                     2e-52)"
                     /gene_kind="transport"
                     /locus_tag="ctg1_1838"
                     /transl_table=11
                     /translation="MIELKQVSKSFGERELFSNLSMTFEAGKVYALIGSSGSGKTTLMN
                     MIGKLEPYDGTIFYRGKDLANYKSSDFFRHELGYLFQNFGLIENQSIEENLKLGLIGQK
                     LSRSEQRLRQKQALEQVGLVYLDLDKRIFELSGGESQRVALAKIILKNPPFILADEPTA
                     SIDPATSQLIMEILLSLRDDNRLIIIATHNPAIWEMADEVFTMDHLK"
     aSDomain        7025..7630
                     /aSDomain="TIGR03608"
                     /aSTool="tigrfam"
                     /description="L_ocin_972_ABC: putative bacteriocin export
                     ABC transporter, lactococcin 972 group"
                     /detection="hmmscan"
                     /domain_id="TIGRFam_ctg1_1838_0053"
                     /evalue="5.50E-78"
                     /identifier="TIGR03608"
                     /label="ctg1_1838"
                     /locus_tag="ctg1_1838"
                     /protein_end="205"
                     /protein_start="3"
                     /score="259.1"
                     /tool="antismash"
                     /translation="LKQVSKSFGERELFSNLSMTFEAGKVYALIGSSGSGKTTLMNMIG
                     KLEPYDGTIFYRGKDLANYKSSDFFRHELGYLFQNFGLIENQSIEENLKLGLIGQKLSR
                     SEQRLRQKQALEQVGLVYLDLDKRIFELSGGESQRVALAKIILKNPPFILADEPTASID
                     PATSQLIMEILLSLRDDNRLIIIATHNPAIWEMADEVFT"
     PFAM_domain     7067..7504
                     /aSDomain="ABC_tran"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00005.29"
                     /description="ABC transporter"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_1838_0117"
                     /evalue="3.30E-31"
                     /label="ctg1_1838"
                     /locus_tag="ctg1_1838"
                     /protein_end="163"
                     /protein_start="17"
                     /score="108.7"
                     /tool="antismash"
                     /translation="SNLSMTFEAGKVYALIGSSGSGKTTLMNMIGKLEPYDGTIFYRGK
                     DLANYKSSDFFRHELGYLFQNFGLIENQSIEENLKLGLIGQKLSRSEQRLRQKQALEQV
                     GLVYLDLDKRIFELSGGESQRVALAKIILKNPPFILADEPTA"
     CDS             7789..7950
                     /locus_tag="ctg1_1839"
                     /transl_table=11
                     /translation="MKKFDNYIIEKPCDSNSDKLQKILIIESLVDDILQFSLRINNSVG
                     EIFLLQPF"
     CDS             complement(8576..8989)
                     /locus_tag="ctg1_1840"
                     /transl_table=11
                     /translation="MEQTFFIIKPDGVKRGLVGEVLKRIEQRGFTIEKLEFRSQVSEEL
                     IDQHYQDLVGQSFYPPIREFMTSGPVLVGVISGPKVIETWRTMMGATRPEEALPGTIRG
                     DFAKAAGENEIIQNVVHGSDSEESAKREIALWF"
     PFAM_domain     complement(8579..8986)
                     /aSDomain="NDK"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00334.21"
                     /description="Nucleoside diphosphate kinase"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_1840_0118"
                     /evalue="6.90E-47"
                     /label="ctg1_1840"
                     /locus_tag="ctg1_1840"
                     /protein_end="137"
                     /protein_start="1"
                     /score="158.9"
                     /tool="antismash"
                     /translation="EQTFFIIKPDGVKRGLVGEVLKRIEQRGFTIEKLEFRSQVSEELI
                     DQHYQDLVGQSFYPPIREFMTSGPVLVGVISGPKVIETWRTMMGATRPEEALPGTIRGD
                     FAKAAGENEIIQNVVHGSDSEESAKREIALWF"
ORIGIN
        1 ttaattatct tcatcaccaa caggtgctct gccaaataaa tcttcaaata aaaccgcatt
       61 ggtttcaagc tgagtaactt cttcttgtcc caaagaacgt cggagtatat tttgcatttc
      121 caacatatgt gctctcgaaa caatctggta agaaacacct tgaagtatct ctccttcacc
      181 ctgcaactgc tgagtttcaa tggttttaaa tgaatcttta tagcctagca agttagggat
      241 actttttgca gacaaatcaa tattggtctg catattgtca ctcaaagctt ttagaatctc
      301 ttgataatga ccaacgctat ttaaactgag agctttttcc atgacttttt gaataacttc
      361 acgttgacgt ttttgacgac cataatcccc ctcaggatct tggtaacgca ttcgtgcata
      421 gactagggct tcttctcccc caatatgttg ctccccaaca ccgatagaaa tagtattaaa
      481 ttcttcttgg tcactgatag aaattgggaa acctaggata ttattgactg taatacctcc
      541 tactgcatcc actagttttt gcaaccctct catattgacc atcacatagc gatcaatatg
      601 gatattcatc attttttgaa tggtttctat agcaagctct gctccaccat ctgcatatgc
      661 tgagttcagt ttcgcttcat gagcctgacc attccctgat tcaatgcgcg tcagaatatc
      721 ccgctctaaa ctcatcattg ttgttttttt cgttttagga ttcactgtca tcaagatcat
      781 gctatcactt ctaccgaccc aagtttcagt tcgttcagca tttccggtgt ccactcccat
      841 taacagaatg gttagaggtt cagtcgcttc aataaccttg gtttcttcgc cgattttttt
      901 ataggtttta gctaaggttt ctgtcccttg ttgataaata gtataagcaa aaacacctac
      961 tcctactaca gttacagaaa gtaaagctag caccattcca ataatttttt taaccatatt
     1021 tctactaatc tatcagttta cccatcaagt aaacatcgat aaatttccct tcttctatat
     1081 atgccccacg ctcttggcta ccttcaatga caaagccatg cttttgataa agatggactg
     1141 ctgcttgatt acgagtttgg acagtcagtt ggagacgacg cagaatgcca cttgcttgtg
     1201 cccactctat cgcttcttct agcaacaaac ttcccaagcc attattccaa tatctttttc
     1261 caatcacaat gaagagatct ccaatatgac ggactctctt acgctggtca gctgtaatat
     1321 ttacaatacc agcaattttg ccatttaaga atgcaagtaa ggttatctga ttgtccgaac
     1381 tagcttgctt gttgaggaat atttccatct cctcactagt caagagaata ccatctccgt
     1441 ctaggctggt aaagtctgtc tccaaactca cacgatttaa aaaggccact aattcagctg
     1501 catctttggg ctctgcttcc ctaatgagca attcatactc catattgaag ctcctctaac
     1561 aatttctcag cacgcaaacc ctttgcctga aaatttaaac ggcgtccatc tgcttctttt
     1621 agaatttcca attctaaata agcatctggc aaggcatctc ctaagagatt tccccactca
     1681 ataacagtca cgccgccacc aaagataaac tcatccaagt cgatagaatc agcatctcct
     1741 tcaatacgat aaacatctag gtgataaagt ggaagtcgac cttcatactc tctcacgata
     1801 gtataggtag gacttttaat catttgagaa atctgtaatc cttttgcaag tcctttagta
     1861 aaggtcgttt tacctgcacc cagttctcca attaagatta aaacatcatt ctttgctaat
     1921 agatggccca aacgctcccc taaggcttgc aactcttctt cattttttgt gtacatactc
     1981 ttattatacc aaaaactttt cttttgtgtc tattttccta ctaaacttat catcataaca
     2041 tccataaaaa acaggctttc tctaaaagaa aatgagcgta acaatgacca atacaagatc
     2101 tcggaaaata tgaccataaa aggaaacttc cttcttaacc gaatttggga caagataggc
     2161 tgcaaaaaac aagcccagtc cagtataaat cagaagtgag acaatggtca ttggatttct
     2221 taagaaaaga agtgttgcta aaatagtcac caacactgtc ttttttctgt ctagcatagc
     2281 aagaaaatcg cgcacgtatt ttttcaaggg taaaaaaatc agcaaatcta gcccaaatag
     2341 gaaaaagaag gatggcaata aaaagtcaac taattcttgc tgcagcgtat ttttgatgaa
     2401 caagttatct gacaaaacaa gaacagctcc taacaaatta attaagagta acatactgta
     2461 aaaaagcttc accgacttct tactggctag gacactatgg acttcttgct tacgggtata
     2521 aagataattt actccagcac agattcctga aacgaaaacc atgcttccga tgaaaaaagc
     2581 tgtactttgt ttaaaggaca agatgcattc cttccatagg aaacagctac tcaaactgat
     2641 ttgaattaaa gctaacaaaa ataagattct cattgatttc atcttctctc tcccttccta
     2701 ccaatcatta tactaggaga aaagagagaa ctgtttctaa tcttctcaaa tgtctcttta
     2761 agacgctaaa caaacactag agactaatac tcaatgaaaa tcaaagatca aactaggtag
     2821 ctagccacag gttgctcaaa acagtgtttt gagattgcag atagagctga cgtggtttga
     2881 agagattttc gaagaatata aatttgaaat catgaaaatc cgtcaaacgg gtggttgttt
     2941 tgtctcgcac ctcacggagc gagacggact cagagtcaca taatgataag gctgatagta
     3001 ttaatctaac tatcagcctt acaggttatt taacgtttca gaaaaactat aatgtcaaga
     3061 ttaactaaac agtatctaat tccttcaaat aattttctat cttcatcaac attaaaggat
     3121 tgttataaat cttacataac tctcttgctt ctatataata atttttgact tgttctctgt
     3181 ctagaaattt ggctccagca tttcctacaa gaataagtag aggagccaat tggtagcttg
     3241 tctgtctttg tttacagagt tcaatcgttt caagagcttc ttggatggct tcattatatt
     3301 tttcctttga tactaggtag tgagcgtagt tgtaacgaac tctgatgtag ccaaataaaa
     3361 actcttgatg gtccaaattt tttgtctgat acaactctat taaatgagag tagtttgcct
     3421 catattcttg ttcacgaccc actaaggaat agaaattaga tagagtattc aacgccttta
     3481 aataaatcag agtatttgaa gagactttta ataatatatt ttccaatgaa gaaattgcct
     3541 cacacttact gtcatattga tagaagtcaa taatagcttt aatccattca agataagttc
     3601 ggtcttctag tgttagaaaa gtacttcgtt caatctcaat tctataaata tattccaaat
     3661 tatcataatt tctgtcatct aatagtcgag cagacaattg cttgaaatta gagaggttag
     3721 atttaatttc aatttgttca ttaaaaaaat aatctaatgg tacttcaagt cgttgtgaga
     3781 gtttgaacaa aaggtctgcg gagggaatga aatgccctct ctcaatttta ctaatctgac
     3841 tttgttcaca aattccttct gcaagagttt gttgggagag tctcaactct tttcttttca
     3901 atctgaattt ctctgcgagt gtattcatta aagataataa accttcctat ttgcttaatt
     3961 tcattataaa atttttagtt caaaatagta agttaaagaa acaaataatt ctttatggta
     4021 ataaataaaa aaagtcaaaa attacataaa aatacttgac cgaataatat atatatgtta
     4081 aaataaaaac aaggaaaaag aaaggggttt cacgaatgaa gaaaaatcgt ggaattcaaa
     4141 aattagctat attagtatta ctaggtgttt ttatgtttag taacacaatt ccttaccaac
     4201 agttattcag aagaatagac aattggagat tcgagtgcaa tcacaaaaga agtccaatgg
     4261 tcttgatgtt gggaaggctg attgatttcg tattacttta aaattcaact atttagagaa
     4321 aggtattctg atgagagctt gtaacaatac cagatagata taagaatgga gatgtttgat
     4381 aaaatgcttt catagctaac caactgttga aaattatgag ttacaaaatc taaagtattt
     4441 aagattggtt tataaaatta ggtctctgcc tgtagaaagg aacgtgcagt tagaaaggag
     4501 gaaaaaatag gatactataa ttcagactga gatttctaat taaaatatgt agttgcattt
     4561 cgctcatttt cataatattt catttagagg agtaataata tgttaaaatt tagaaaagta
     4621 gttgcatcat cccttgccgt tttggcattt agtttggctc ttcctgtttt ggcagtttct
     4681 caccgtggtg gcgagtggac ctatggaggc catcatgatc catataattg gggagcattt
     4741 tcgaattatt atcatggttc acagtatcac tgggcctatg ttggaagtaa tgaacgtgac
     4801 aatcaaaaaa cagtttatgc aggagcacat agtgcggcct atgcgtttgt taatacaaat
     4861 ttgggggagc gaattacatt tgatgcggga tggtaaagaa taattgaaga agattctttt
     4921 atcaatagtt tagtaagctt gttagtttat agagggcagg ggtatttctg ccctctgttt
     4981 tagaataagg aatgcactat gaaaaaatta tttatactca tatccaacct gcttgctagt
     5041 ttgttctttg tttgggtatt taccatttgg actgatacat atgtctccca ttattacccc
     5101 aacgttgttg tacatgattc ttcccctgaa acaacttttc agcatgttgc tacacgcttg
     5161 gaaaaactag cagaagaaac agatagcttt attgcgattc aacaccaaga tcctaactca
     5221 gaaggtacta cagttttttc ttatacgacc tttggagacg gaaagttgcc tgacgggcta
     5281 caggaaaaaa aactagaaga tgctcaaagt agtagtgttg aaacaaacta ttttgtattc
     5341 gatggacacc tagatattca cttgctaagg gaggagctaa gtcaacttgg cttgactaat
     5401 atgcacctga caattccatc taaactatct acgttaatgg ctatctttag taacggattt
     5461 cagttaatca gtctattgat tttcatctta acctttggag cactgacttt aattagtcaa
     5521 attagccaat tacggtcgtc gggcattcgc ctcatttcag gagagaaacg gtggtccatt
     5581 tttcttagac cagttggtga ggatttgaaa gggatagctg ttggtttcag tttagctggc
     5641 gtgctcacca ttcttatgca aaaaattctg tcgcttccaa cgcaatccct aatgaccata
     5701 ggagcaggct tgctcagtta taatctcatc ttgttgtcta tctccctgtt tttcgctcaa
     5761 ctcttcgcag ttgggataaa aaagatacac ctgatgcaga ttataaaagg gcaagtgcct
     5821 gtcagaggaa tcattagttt gattttaatc ggtcaactat tagcgattat tattgtaaca
     5881 ctgggaatag ggagtagctt aaagtattcc caagcctggc aacagcatcg gattggacaa
     5941 gaggcttgga gccaggaaag gcaactgatt accctatcaa tcagccgtga aggaacgagt
     6001 cctggttttg atgaacaagc tcaaaggaaa ctcagaactt ggtatcaatt gatggatctg
     6061 gctgtttcag aacaaaaggc tttcttatct agacaccagt taattgaccg tactttgcaa
     6121 aatggcatgg cttcctccaa aaactttata acctctacag aatggcacga ttacagcccg
     6181 aatggcaatg tccttatcgt cacaccgcaa tacttggagc gtcaaaacat tcctgtagat
     6241 acaactattg agcaaaagat gaatcacctt gatgtagggg agtttgtctt attgctgcct
     6301 gaacacctcc gttcagagga agatcattat aaatctgttt ttgaagacga cttaaccagt
     6361 cgcatgtcta gtcaagatga acgacagcaa atgactgcta cggtaggtta tttagaatca
     6421 ggtcaggatc gttttgtgta taatacgacc cctatttctt accagcagtt tttgaaagat
     6481 ccaatcatca ttgttataac accccaatca actggtccac agtccatttt gttttggata
     6541 gacgcagtac agaactacgt tctctttaat caattgtctg atgcccagga gcttatccag
     6601 agacaaggca ttgaaaattg ggtctcagaa atgcaaacag gttaccacaa ctacatcaca
     6661 ttattggata atatccagag ggaacgttgg gtaatgctag caggagctgt gcttgggatt
     6721 gcaacttcaa tcttgctgtt taacactatg aataggctct actttgaaga atttagacgt
     6781 gccattttta tcaaacgcat tgcaggtctc aggttcttag aaatccatcg cacttatctc
     6841 tttgctcaac tgggtgtgtt tttactggga tttgttgcta gtgtatttct tcaggtagaa
     6901 ataggagttg ctttcttagt cttgttactc tttactggtc tatctctttt acagttacat
     6961 gtccaaatgc agaaagaaaa caagatgtcc atgcttgttt tgaagggagg ttaatatgat
     7021 tgaacttaaa caggtgagta aatcttttgg agaacgagag ttattttcga atctttcaat
     7081 gacatttgag gctggaaaag tctatgcctt aattggttca agtggtagcg gaaaaacaac
     7141 cttgatgaac atgattggga aattagaacc ttatgatggg acgatttttt accgaggtaa
     7201 agacttggcc aattataaat caagtgattt tttccgtcac gaattgggct acctcttcca
     7261 gaactttggc ttaattgaaa accaaagtat tgaagaaaac cttaagctag gtctcattgg
     7321 tcaaaagttg agtcggtcgg aacagcggtt gaggcagaag caggctttag aacaggtcgg
     7381 cctggtttat cttgacctag ataagcgcat ctttgagtta tcgggcggag aatcgcaacg
     7441 ggttgccttg gcaaaaatta tcttaaagaa tccacccttt attctggcag atgagccaac
     7501 agcttcaata gacccagcaa cctctcagtt gattatggag attttgctat ctcttcgaga
     7561 tgataatagg ctaatcatta tcgcaacaca taatccggca atttgggaga tggctgatga
     7621 agtgttcacg atggatcatc tgaaataaaa atccttgttt ttaattgcac gatgagttac
     7681 tgaaatatta tcatgaatca agaattggag ttaatttaga attgtacttt attaatattg
     7741 aggtaacttt ttcttgataa aggaagaaat aatggagagg aagttagaat gaaaaaattc
     7801 gacaattata ttattgagaa gccttgcgat tctaattcag ataaactgca aaaaatctta
     7861 ataattgaaa gtttggtaga tgatattttg caattttctc tcagaatcaa taatagtgta
     7921 ggagagattt tcctcctaca accgttttaa aagaaaacta tctttattcc atgttatttt
     7981 gaggaagata ttgtgaaagt caaagatgat gataaagttg agtggaattt gttagaattt
     8041 caaaaattta gagcattttt ggcttagtaa tctgtgttga aggctcaaaa cctatggtaa
     8101 aaaagtagct ttgaaaacgt attgcctcca aagatttagt taaataatga tttaacacaa
     8161 aaagaaatta ttgaagttct ggaaagatgt tgtttcagta ttgagaaaag gtgggaaaaa
     8221 cttgcgattt tcacagagaa aggaagaaaa agtatagaaa tatagtcaat tgaaacaaga
     8281 acaggataaa agaacctttt gtgccatatt tttctccttt cgctttacaa ttggattgaa
     8341 cacctttatt gtatcgcgtt tggagttttt ttggtataac cttcgacgcg cacccgcata
     8401 gcgggtgttt ttttgtctcg cacctaacgg agcgagacaa actaatagtc acttaatcaa
     8461 aaaacgcacc atatcaaaaa ctaaaaagtt tgatatcatg cgtcatgtct taaactaatt
     8521 gactatactt tctattcaaa tgagctttta accaattgat tgagccaatc cactcttaaa
     8581 accaaagagc aatttctcgc ttagctgact cttctgaatc tgaaccatgt acaacatttt
     8641 ggataatctc attttctcca gcagcttttg caaaatcacc tcgaatagtg cctggtaaag
     8701 cttcttctgg acgagttgca cccatcatgg tccgccaagt ttcgattact ttgggaccag
     8761 aaatgacacc cacaagaact ggacctgaag tcatgaattc acgaatcggt gggtaaaaac
     8821 tctgaccaac caagtcctga tagtgctggt caatcaactc ttctgaaacc tgtgaacgaa
     8881 actccaattt ttcgattgta aatccacgtt gttcgatgcg ctttaacact tcacccacta
     8941 gccctctttt tacaccatct ggtttgatga taaagaatgt ttgttccat
//
