LOCUS       NZ_CP020549.1           8289 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  NZ_CP020549.1 Streptococcus pneumoniae strain Hu17 chromosome.
ACCESSION   NZ_CP020549
VERSION     NZ_CP020549.1
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 6.1.1
            Run date     :: 2024-03-14 13:01:09
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 138067
            Orig. end    :: 146356
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     CDS             complement(1..672)
                     /locus_tag="ctg1_144"
                     /transl_table=11
                     /translation="MKSLRFQSVFDIIGPVMIGPSSSHTAGAVRIGKIVSSIFDDTPTE
                     VEFQLFNSFAKTYRGHGTDLALVAGILGMNTDDPEIPNSLEIAHKRGIKIVWTIQKDSN
                     APHPNTTKITVKNAHKTISVTGISIGGGNIQVTELNGFAVSLNMNTPTIIIVHQDIPGM
                     IALVTEALSRYGINIAQMNVTREKAGEKAIMIIEVDSRNCDEAIEEIRKIPHLHNVNFF
                     K"
     protocluster    1..8289
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[142293:142542](+)"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193)"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      4227..4475
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193)"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
     cand_cluster    1..8289
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193)"
                     /kind="single"
                     /product="RiPP-like"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..8289
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="RiPP-like"
                     /region_number="2"
                     /rules="(strepbact or Antimicrobial14 or Bacteriocin_IId or
                     BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or
                     Lactococcin or Antimicrobial17 or Lactococcin_972 or
                     Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or
                     TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or
                     TIGR03975 or DUF692 or TIGR01193)"
                     /tool="antismash"
     PFAM_domain     complement(31..219)
                     /aSDomain="ACT"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF01842.27"
                     /description="ACT domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_144_0017"
                     /evalue="1.00E-09"
                     /label="ctg1_144"
                     /locus_tag="ctg1_144"
                     /protein_end="214"
                     /protein_start="151"
                     /score="38.1"
                     /tool="antismash"
                     /translation="TIIIVHQDIPGMIALVTEALSRYGINIAQMNVTREKAGEKAIMII
                     EVDSRNCDEAIEEIRKIP"
     aSDomain        complement(52..657)
                     /aSDomain="TIGR00719"
                     /aSTool="tigrfam"
                     /description="sda_beta: L-serine dehydratase,
                     iron-sulfur-dependent, beta subunit"
                     /detection="hmmscan"
                     /domain_id="TIGRFam_ctg1_144_0007"
                     /evalue="2.40E-68"
                     /identifier="TIGR00719"
                     /label="ctg1_144"
                     /locus_tag="ctg1_144"
                     /protein_end="207"
                     /protein_start="5"
                     /score="228.0"
                     /tool="antismash"
                     /translation="FQSVFDIIGPVMIGPSSSHTAGAVRIGKIVSSIFDDTPTEVEFQL
                     FNSFAKTYRGHGTDLALVAGILGMNTDDPEIPNSLEIAHKRGIKIVWTIQKDSNAPHPN
                     TTKITVKNAHKTISVTGISIGGGNIQVTELNGFAVSLNMNTPTIIIVHQDIPGMIALVT
                     EALSRYGINIAQMNVTREKAGEKAIMIIEVDSRNCDEAI"
     PFAM_domain     complement(439..651)
                     /aSDomain="SDH_beta"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF03315.17"
                     /description="Serine dehydratase beta chain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_144_0016"
                     /evalue="3.00E-11"
                     /label="ctg1_144"
                     /locus_tag="ctg1_144"
                     /protein_end="78"
                     /protein_start="7"
                     /score="44.0"
                     /tool="antismash"
                     /translation="SVFDIIGPVMIGPSSSHTAGAVRIGKIVSSIFDDTPTEVEFQLFN
                     SFAKTYRGHGTDLALVAGILGMNTDD"
     CDS             914..1501
                     /locus_tag="ctg1_145"
                     /transl_table=11
                     /translation="MKSITKKIKATLAGVAALFAVFAPSFVSAQESSTYTVKEGDTLSE
                     IAETHNTTVEKLAENNHIDNIHLIYVGQELVIDGPVAPVATPAPATYAAPAAQDETVSA
                     PVAETPVVSETVVSTVSGSEAEAKEWIAQKESGGSYTATNGRYIGRYQLTDSYLNGDYS
                     AENQERVADAYVAGRYGSWTAAKNFWLNNGWY"
     PFAM_domain     1016..1144
                     /aSDomain="LysM"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF01476.22"
                     /description="LysM domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_145_0018"
                     /evalue="1.00E-14"
                     /label="ctg1_145"
                     /locus_tag="ctg1_145"
                     /protein_end="77"
                     /protein_start="34"
                     /score="54.4"
                     /tool="antismash"
                     /translation="YTVKEGDTLSEIAETHNTTVEKLAENNHIDNIHLIYVGQELVI"
     CDS             complement(1553..2416)
                     /locus_tag="ctg1_146"
                     /transl_table=11
                     /translation="MRYDFGKVYKEIRESKGLTQEEVCGNVISRTSLSKIESGKATPKY
                     ENMEFLLRQINMSFEEFDYICHLYQPSQRTEIMQTYLNMTSIIGSNSLVHFFETCQDYL
                     KTHHDLPIEEIRDMLEIVIHIRQHGTEQLSNQVKQTVTKLWEKIEKQDTWYENDLKILN
                     TILFSFPIDHLHLITGKILQRLEVYKNYQHLYDLRMAILLNLSTIYLYHQDKNMCRQIC
                     YTLLEDAKKKKHYDRLAICYVRIGICRDDARLIQKGFSLLELTEETSMLSHLKKEVEIY
                     SQPKEI"
     PFAM_domain     complement(2231..2389)
                     /aSDomain="HTH_3"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF01381.24"
                     /description="Helix-turn-helix"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_146_0019"
                     /evalue="2.00E-09"
                     /label="ctg1_146"
                     /locus_tag="ctg1_146"
                     /protein_end="62"
                     /protein_start="9"
                     /score="37.5"
                     /tool="antismash"
                     /translation="KEIRESKGLTQEEVCGNVISRTSLSKIESGKATPKYENMEFLLRQ
                     INMSFEEF"
     CDS             2739..3326
                     /locus_tag="ctg1_147"
                     /transl_table=11
                     /translation="MNYNLKYLLSGIVVLVFIGFLVWMRYFNQRKEEEHSDVSFEARLD
                     SEVKTLYKQLGLGEEPHYFLAYRYLHPWFDLAILPPTVEIFLTKIALVMVTPDELLIRN
                     LGNGLTFTSEHHRDLRQGLIRIPKSEMKEFEIRNWKKFFVFGDFLTIKTSQHSYYLQVR
                     DDGLQKGSLSTKHFSDLKSQDFLGLLTDKRTF"
     CDS             3447..3959
                     /locus_tag="ctg1_148"
                     /transl_table=11
                     /translation="MGXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
                     XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
                     XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
                     XXKSLKI"
     aSDomain        4227..4472
                     /aSDomain="TIGR01653"
                     /aSTool="tigrfam"
                     /description="lactococcin_972: bacteriocin, lactococcin 972
                     family"
                     /detection="hmmscan"
                     /domain_id="TIGRFam_ctg1_149_0008"
                     /evalue="2.00E-18"
                     /identifier="TIGR01653"
                     /label="ctg1_149"
                     /locus_tag="ctg1_149"
                     /protein_end="82"
                     /protein_start="0"
                     /score="64.4"
                     /tool="antismash"
                     /translation="MVCSILASTSVLAVWVDGGQWNYGVGWSGNFGYSDYLHSTRSHTA
                     TVKDGNKFSKDCAEAEAWARASIFKFPPTGMEYFYGF"
     CDS             4227..4475
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: Lactococcin_972"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg1_149"
                     /sec_met_domain="Lactococcin_972 (E-value: 7.3e-31,
                     bitscore: 103.6, seeds: 6, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MVCSILASTSVLAVWVDGGQWNYGVGWSGNFGYSDYLHSTRSHTA
                     TVKDGNKFSKDCAEAEAWARASIFKFPPTGMEYFYGF"
     PFAM_domain     4275..4463
                     /aSDomain="Lactococcin_972"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF09683.12"
                     /description="Bacteriocin (Lactococcin_972)"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_149_0020"
                     /evalue="4.00E-23"
                     /label="ctg1_149"
                     /locus_tag="ctg1_149"
                     /protein_end="79"
                     /protein_start="16"
                     /score="81.8"
                     /tool="antismash"
                     /translation="DGGQWNYGVGWSGNFGYSDYLHSTRSHTATVKDGNKFSKDCAEAE
                     AWARASIFKFPPTGMEYF"
     CDS             4530..6638
                     /locus_tag="ctg1_150"
                     /transl_table=11
                     /translation="MKKISHLCMLLLLLCTTFFVFNVNYTREVVRIQEMGKTVDSLDLY
                     LKDINEPAASVLRFFEDVSKEYKVSIIKTDSGDEVVKSGVFDKDTFPYQEFGISSLDFT
                     TDGEGVYSNKEISNKLGTIPTFLKAKPIQLMTFQTYIKDTSRSLNGRYTITSTQEMDKD
                     RIVQKWSDFFKIDQATLLEPTYKSAVEVINRDLLLSAIVFVLAILLLVLVTVYQPMMEM
                     KRVGVQKLLGFQDRAVLADVVKGNLYLLLGGALVINLGVFFLLDYKPKDLFPMLWLSHF
                     LLLQLYLFISWLTYLLIQKMTISSLLKGFSSFKFGLIFNYVMKIGTTILLTALLIGVGR
                     SLEQENKELAYQQQWVSQGNYLTLETFKLNDNLWQEELAGSGKSTDYFYRFYQDLVEKT
                     QAGYVQSSSLPVKNFVQSEQIQQYQLTDTVDVYYANRNFLKSKGFKLPDTGIKKVILMP
                     ASTKGEEDKNQLLGKLIAFHSMKYEEQQKRTIEEMDVEIAYYEGDWSFFPYSDKRKENL
                     SNPIISLVNDSDMMWDEKASLSTTGLNNPIKIENTVQHQKEITELVEKLSDGNYLKFSS
                     IQAIQQEKVDSYRDAVRNFNLLFALFGLLSMMISYFLLVTTFLLKRRDIITKKFMGWKL
                     VDRYRPLLVLLLLGYSFPLLVLIFFAHAFLPLLLFAGFTCLDILFVLGLASRMEKRSLV
                     ELLKGGIL"
     aSDomain        4554..6626
                     /aSDomain="TIGR01654"
                     /aSTool="tigrfam"
                     /description="bact_immun_7tm: bacteriocin-associated
                     integral membrane protein"
                     /detection="hmmscan"
                     /domain_id="TIGRFam_ctg1_150_0009"
                     /evalue="2.50E-226"
                     /identifier="TIGR01654"
                     /label="ctg1_150"
                     /locus_tag="ctg1_150"
                     /protein_end="699"
                     /protein_start="8"
                     /score="751.3"
                     /tool="antismash"
                     /translation="MLLLLLCTTFFVFNVNYTREVVRIQEMGKTVDSLDLYLKDINEPA
                     ASVLRFFEDVSKEYKVSIIKTDSGDEVVKSGVFDKDTFPYQEFGISSLDFTTDGEGVYS
                     NKEISNKLGTIPTFLKAKPIQLMTFQTYIKDTSRSLNGRYTITSTQEMDKDRIVQKWSD
                     FFKIDQATLLEPTYKSAVEVINRDLLLSAIVFVLAILLLVLVTVYQPMMEMKRVGVQKL
                     LGFQDRAVLADVVKGNLYLLLGGALVINLGVFFLLDYKPKDLFPMLWLSHFLLLQLYLF
                     ISWLTYLLIQKMTISSLLKGFSSFKFGLIFNYVMKIGTTILLTALLIGVGRSLEQENKE
                     LAYQQQWVSQGNYLTLETFKLNDNLWQEELAGSGKSTDYFYRFYQDLVEKTQAGYVQSS
                     SLPVKNFVQSEQIQQYQLTDTVDVYYANRNFLKSKGFKLPDTGIKKVILMPASTKGEED
                     KNQLLGKLIAFHSMKYEEQQKRTIEEMDVEIAYYEGDWSFFPYSDKRKENLSNPIISLV
                     NDSDMMWDEKASLSTTGLNNPIKIENTVQHQKEITELVEKLSDGNYLKFSSIQAIQQEK
                     VDSYRDAVRNFNLLFALFGLLSMMISYFLLVTTFLLKRRDIITKKFMGWKLVDRYRPLL
                     VLLLLGYSFPLLVLIFFAHAFLPLLLFAGFTCLDILFVLGLASRMEKRSLVELLKG"
     CDS             6635..7276
                     /gene_functions="transport (smcogs) SMCOG1000:ABC
                     transporter ATP-binding protein (Score: 193.6; E-value:
                     6.6e-59)"
                     /gene_kind="transport"
                     /locus_tag="ctg1_151"
                     /transl_table=11
                     /translation="MIELKNITKTIGGKVILDNLSLRIDQGDLVAIVGKSGSGKSTLLN
                     LLGLIDGDYSGRYEIFGQTNLAVNSAKSQTIIREHISYLFQNFALIDDETVEYNLMLAL
                     KYVKLPKKDKLKKVEEILERVGLSATLHQRVSELSGGEQQRIAVARAILKPSQLILADE
                     PTGSLDPENRDLVLKFLLEMNREGKTVIIVTHDAYVAQQCHRVIELGEGK"
     aSDomain        6644..7261
                     /aSDomain="TIGR03608"
                     /aSTool="tigrfam"
                     /description="L_ocin_972_ABC: putative bacteriocin export
                     ABC transporter, lactococcin 972 group"
                     /detection="hmmscan"
                     /domain_id="TIGRFam_ctg1_151_0010"
                     /evalue="8.30E-89"
                     /identifier="TIGR03608"
                     /label="ctg1_151"
                     /locus_tag="ctg1_151"
                     /protein_end="209"
                     /protein_start="3"
                     /score="294.4"
                     /tool="antismash"
                     /translation="LKNITKTIGGKVILDNLSLRIDQGDLVAIVGKSGSGKSTLLNLLG
                     LIDGDYSGRYEIFGQTNLAVNSAKSQTIIREHISYLFQNFALIDDETVEYNLMLALKYV
                     KLPKKDKLKKVEEILERVGLSATLHQRVSELSGGEQQRIAVARAILKPSQLILADEPTG
                     SLDPENRDLVLKFLLEMNREGKTVIIVTHDAYVAQQCHRVIEL"
     PFAM_domain     6683..7129
                     /aSDomain="ABC_tran"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00005.29"
                     /description="ABC transporter"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_151_0021"
                     /evalue="2.90E-30"
                     /label="ctg1_151"
                     /locus_tag="ctg1_151"
                     /protein_end="165"
                     /protein_start="16"
                     /score="105.7"
                     /tool="antismash"
                     /translation="LDNLSLRIDQGDLVAIVGKSGSGKSTLLNLLGLIDGDYSGRYEIF
                     GQTNLAVNSAKSQTIIREHISYLFQNFALIDDETVEYNLMLALKYVKLPKKDKLKKVEE
                     ILERVGLSATLHQRVSELSGGEQQRIAVARAILKPSQLILADEPT"
     CDS             7483..8289
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1091:glutamine-binding lipoprotein glnH (Score: 207.5;
                     E-value: 3.1e-63)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg1_152"
                     /transl_table=11
                     /translation="MNKMKKVLMTMFGLVMLPLLFACSNNQSAGIEAIKSKGKLVVALN
                     PDFAPFEYQKVVDGKNQIVGSDIELAKAIATELGVELELSPMSFDNVLASVQSGKADLA
                     ISGVSKTDERSKVFDFSTPYYTAKNKLIVKKSDLATYQSVNDLAQKKVGAQKGSIQETM
                     AKDLLQNSSLVSLPKNGNLITDLKSGQVDAVIFEEPVSKGFVENNPDLAIADLNFEKEQ
                     DDSYAVAMKKDSKELKEAVDKTIQKLKESGELDKLIEDAFKASIEK"
     PFAM_domain     7600..8268
                     /aSDomain="SBP_bac_3"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00497.22"
                     /description="Bacterial extracellular solute-binding
                     proteins, family 3"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_152_0022"
                     /evalue="1.20E-59"
                     /label="ctg1_152"
                     /locus_tag="ctg1_152"
                     /protein_end="262"
                     /protein_start="39"
                     /score="201.6"
                     /tool="antismash"
                     /translation="LVVALNPDFAPFEYQKVVDGKNQIVGSDIELAKAIATELGVELEL
                     SPMSFDNVLASVQSGKADLAISGVSKTDERSKVFDFSTPYYTAKNKLIVKKSDLATYQS
                     VNDLAQKKVGAQKGSIQETMAKDLLQNSSLVSLPKNGNLITDLKSGQVDAVIFEEPVSK
                     GFVENNPDLAIADLNFEKEQDDSYAVAMKKDSKELKEAVDKTIQKLKESGELDKLIEDA
                     F"
ORIGIN
        1 ctatttaaag aaattgacat tgtggagatg agggattttt cgaatttctt cgatagcctc
       61 atcacagttg cgactgtcaa cttcgataat cataatggct ttttcaccag ctttttcacg
      121 agtgacattc atctgggcga tattgatacc atagcgggaa agcgcctctg taacaagggc
      181 aatcatacct ggaatatctt gatgaacgat gatgatagtc ggtgtattca tattgagaga
      241 gacggcaaaa ccattgagtt cggttacctg aatatttcct ccaccgatag aaataccagt
      301 cacgctgatg gtcttgtggg catttttaac agtaatttta gtggtgttag ggtgaggggc
      361 attgctgtct ttctgaatgg tccagacaat cttgatacca cgcttgtggg caatttccag
      421 actatttgga atttcaggat catctgtatt cattcccaaa atacctgcaa caagggctag
      481 gtctgttccg tgaccacgat aggtcttggc aaatgagtta aaaagttgga attcaacttc
      541 tgtcggagta tcatcaaaaa tggaagagac aatcttccca atacgaacag caccagcggt
      601 atggctacta gatgggccaa tcataactgg tccgatgata tcaaagacag attgaaaacg
      661 aagtgatttc atcagtttcc ccttataaaa attcttatct ctattatatc aaagaatgag
      721 gggcttggct ttaattgtgg atgaaaacct ttctaatacc tcaaatagca taaaaatagt
      781 atcttttatg acaaaaaaca ccttatttag ggaaataaaa aataattttg taatatttct
      841 acataaaagt gtcaagaaac ggtaatattt aaagggtatg atagaactat agaaagaagg
      901 agaattttcg aatatgaaat caataactaa aaagattaaa gcaactcttg caggagtagc
      961 tgccttgttt gcagtatttg ctccatcatt tgtatctgct caagaatcat caacttacac
     1021 tgttaaagaa ggtgatacac tttcagaaat cgctgaaact cacaacacaa cagttgaaaa
     1081 attggcagaa aacaaccaca ttgataacat tcatttgatt tatgttggtc aagagttggt
     1141 tatcgatggc cctgtagcgc ctgttgcaac accagcgcca gctacttatg cggcaccagc
     1201 cgctcaagat gaaactgttt cagctccagt agcagaaact ccagtagtaa gtgaaacagt
     1261 tgtttcaact gtaagcggat ctgaagcaga agccaaagaa tggatcgctc aaaaagaatc
     1321 aggcggtagc tacacagcta caaacggacg ttacatcgga cgttaccaat taacagattc
     1381 atacctgaac ggtgactact cagctgaaaa ccaagaacgt gtagcagatg cctatgttgc
     1441 aggacgttac ggttcatgga cagccgctaa aaacttctgg cttaataacg gctggtatta
     1501 agaaataacg agcagaataa tatgaaaagg tcgaggaaat ccctcgactt ttttatattt
     1561 ccttcggttg agaatagatc tctacttctt ttttgagatg agacagcata gaagtttcct
     1621 cggtcagctc cagaagtgag aaaccttttt ggataagtct agcgtcatcc ctacaaatcc
     1681 cgatacggac atagcagata gcaagtctat cgtagtgctt ctttttcttg gcatcctcta
     1741 gtaaagtata gcagatttgt cgacacatat ttttgtcttg atggtataag taaatggtgg
     1801 acagattgag taggattgcc attcgtaagt catataaatg ttggtagttt ttatagactt
     1861 ctaagcgttg caagattttt ccagtaatga gatggaggtg atcaatggga aagctgaaaa
     1921 ggatggtatt gaggattttt aggtcatttt cataccatgt atcttgtttc tcaatttttt
     1981 cccaaagttt tgtgacagtc tgtttcactt ggtttgacag ttgctctgta ccatgttgac
     2041 ggatatgaat gacaatttcc agcatatccc ttatttcttc tataggcagg tcgtggtggg
     2101 tcttgagata gtcttggcat gtttcaaaaa aatgaactag actattacta ccaatgatgg
     2161 aagtcatatt gagataagtt tgcatgattt ctgttcgttg gcttggttga tagagatggc
     2221 agatgtagtc aaactcttca aaactcatat tgatttgccg gagaagaaat tccatgtttt
     2281 catatttggg agttgctttg ccactttcaa tctttgatag gctagttctt gagatgacat
     2341 ttccacagac ctcttcttgg gtcaatcctt ttgactcgcg tatttcttta tagacctttc
     2401 cgaaatcata acgcatgatt cactcctttt cgtgaaaaaa gttaacaaat aataaaatcc
     2461 tattaaaaat attgtatcat agtaatataa aaagtaaaaa agaaagataa aataagtttg
     2521 gtgtaatttt aatatggggt taatgagtac tatgatgtag ctagaaaagg ggtggaaaaa
     2581 tgtttaaaaa taaggaactt tttcgagtag tcatgatatt tgtgatagga attatcctaa
     2641 ttttaatgac acccgtctta tttaaagtta tgatggaact attttcaaaa taaataggcc
     2701 tctgttttag gcagaagcgt gaatcaggaa gttaagtgat gaactacaat ttaaaatatc
     2761 ttttatcagg aatagttgtc ctagtcttta taggtttcct agtctggatg cgttatttta
     2821 atcagaggaa ggaagaagag cattcggatg tgtcttttga agcgaggtta gatagtgagg
     2881 tcaagacctt atataaacaa ctaggattgg gtgaggagcc tcattatttc ttagcgtatc
     2941 gctacctaca tccttggttt gatttggcga ttttaccacc aacagttgaa attttcttaa
     3001 ctaaaatagc gctggtgatg gtaactccag atgaactact gataagaaat cttgggaatg
     3061 ggctgacttt cacaagtgag catcatcgtg atttgcggca aggacttatc cgcattccaa
     3121 aatcagagat gaaagaattt gagattcgta actggaaaaa attttttgta tttggcgatt
     3181 ttttgacaat taaaacaagc caacatagct attatttaca ggttagagat gatggacttc
     3241 aaaaaggaag cctttctacc aaacatttct cagacttgaa gagccaagat tttctcggat
     3301 tattgacaga taaacggaca ttctgataga cgattgccct agttgtttat tgtaaacttt
     3361 gcaaatttgg cttgtaattt tttttataaa attcacttcg attacttgac agttattata
     3421 ttttcactta ttatatagat aaaaggatgg gannnnnnnn nnnnnnnnnn nnnnnnnnnn
     3481 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
     3541 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
     3601 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
     3661 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
     3721 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
     3781 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
     3841 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
     3901 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn taagagttta aaaatttgaa
     3961 agcgctatcc atattgttta ttgggctgat tcttgagtaa tagttagagt gtgattaata
     4021 ctactctggt tgttcaaaga cctgatacag aagagaacta ttcttctagt taagagtaag
     4081 ttcgttgttt aaaaatgaaa tgagatagaa ggaaggtgag tccaatggac tacgatactt
     4141 gttgacaaat tactatagct gtttctacgg aatagctctc gataatagga gaaataaatc
     4201 atgagaaaat tggtgttgca tctttaatgg tatgtagtat acttgcttct acaagtgttt
     4261 tggcagtatg ggttgatggt ggtcaatgga actatggagt aggatggtca ggaaattttg
     4321 gttattctga ttatttacat tctactcgct ctcatacagc aactgttaaa gatggaaata
     4381 aattctctaa ggattgtgca gaagctgagg catgggctcg ggcttcaatc ttcaaattcc
     4441 caccaacggg aatggaatat ttctatggat tttaattaaa attctccctc cccttttgga
     4501 gagggagttt cttcacggga ggtatctcta tgaaaaaaat cagtcatctt tgtatgttac
     4561 tcctgcttct gtgtaccact ttttttgttt ttaatgtaaa ctatacacga gaagtggttc
     4621 ggattcaaga aatgggaaag actgtagatt ctttggattt gtatttgaaa gatattaacg
     4681 aacctgcagc gtctgttctt cgattttttg aggatgtatc aaaggagtat aaagtctcca
     4741 tcatcaaaac agacagtggt gatgaggtgg tcaagtctgg tgtttttgat aaagatacct
     4801 tcccctacca agagtttggg atttcttctc ttgattttac cacagatggt gaaggagtct
     4861 atagtaataa agaaatttcc aataaacttg gtacgattcc gacctttcta aaagccaaac
     4921 ctattcagct tatgactttt caaacctata tcaaggatac atctcgtagt ttaaatggtc
     4981 gctatacgat aacttctaca caagagatgg acaaggatag gattgtacag aaatggagcg
     5041 attttttcaa gatagaccag gctaccttgc tagagccgac ctacaaaagt gcagtggaag
     5101 tcataaatcg agatttgctt ttatctgcca ttgtttttgt cttggctatt ttgcttcttg
     5161 tgttagtgac agtgtatcaa ccgatgatgg agatgaaaag agttggggta caaaaattac
     5221 ttggttttca agatagggct gttttagctg atgttgtaaa aggcaacctt tacctcctcc
     5281 taggtggggc tcttgtgatc aatctaggcg tgtttttctt gcttgattat aagccaaaag
     5341 atttgtttcc tatgctgtgg ttgtctcatt ttttgctgtt gcagctttat ctctttatca
     5401 gttggttgac ttacctctta atccaaaaaa tgacaatcag ctctctgctg aaaggttttt
     5461 catctttcaa atttggtctt atcttcaatt atgtgatgaa aatagggaca actattttac
     5521 tgacggcctt actgattggg gtgggcagaa gtttagaaca agaaaacaaa gaacttgctt
     5581 atcagcaaca gtgggtaagt caaggtaatt acctgacctt agaaaccttc aaactcaatg
     5641 ataatctgtg gcaagaagag ctagcagggt cagggaaatc tacagattat ttctatcgat
     5701 tttatcagga tttggtagaa aaaacgcagg cgggctatgt gcagagtagc agtcttcctg
     5761 taaaaaattt tgtccaatca gaacagattc agcaatatca gttaacagat acggtggatg
     5821 tttactatgc caatcgcaat tttctaaaga gcaagggatt caagctacca gataccggta
     5881 ttaaaaaagt tattttgatg ccagcaagta cgaaaggtga agaagataaa aatcagctct
     5941 tggggaagtt aattgccttt cattcgatga agtatgaaga gcagcaaaaa cgaacgatag
     6001 aggagatgga tgtcgagatt gcctattatg aaggagattg gtcatttttc ccatatagtg
     6061 ataagcgaaa ggaaaatctc tccaatccaa ttattagctt ggtcaatgat tctgatatga
     6121 tgtgggatga gaaagcctcc ctgtcaacaa ctggcttaaa taatccgatt aaaattgaaa
     6181 atacggttca acatcaaaaa gagattacag agttagttga gaaattgtca gatggaaatt
     6241 atttaaaatt ttcatctatt caagccattc aacaagagaa agtggattct tatcgagatg
     6301 ctgttcggaa ttttaaccta ctctttgctt tgtttggtct ccttagcatg atgatttcct
     6361 acttcttact agtaacaact ttcttattga agcgcaggga tatcattacc aagaagttta
     6421 tggggtggaa actggtcgat cgctaccgtc ctctcctcgt tctgctcttg ctgggctata
     6481 gtttccctct tctagtcttg attttctttg cccatgcgtt cttaccactt ctactgtttg
     6541 caggttttac atgtctggat atactatttg tgctaggctt agcttctagg atggagaaaa
     6601 gaagtctagt agagttattg aaagggggca tcttatgatt gagttgaaaa atattaccaa
     6661 aaccattggg ggaaaagtga ttttggataa cttatctctc aggattgatc agggggattt
     6721 ggtagctatt gttggtaaga gtggtagtgg gaagtcgacc ttgttaaatt tattgggttt
     6781 gatagatggt gattatagcg gacggtatga gatttttggt cagacaaatc tagcggttaa
     6841 ttctgctaag tcgcaaacaa taatccgtga acatatctct tatctgtttc aaaattttgc
     6901 cctgattgat gatgaaacgg tcgagtacaa tctcatgctg gcgctgaaat atgtgaaatt
     6961 gcctaagaaa gacaagctca aaaaggtgga agagatttta gagagagtag gtttgtcagc
     7021 tactttgcat caaagggtct ccgagttgtc tgggggcgaa caacaacgaa ttgcagttgc
     7081 tagagccatc ttaaaaccca gccagctgat tttagccgat gaacctacag gttcgctgga
     7141 tcctgaaaat agagatttgg tcttgaagtt tctcttagag atgaatcgag aagggaaaac
     7201 agtcattatt gtgacccacg atgcttatgt agcccaacaa tgtcatcgtg tcattgaatt
     7261 gggcgaggga aaatgagttc attcagctcc ttttgactgg ctgaatactc atgttttcca
     7321 gagaaaaata gcataaatac gcctaggaat gacattttat gtagtatttc taggtttttt
     7381 ttgtttcaaa ttgaaaattt tttcaattta ggcttgacaa aggatgagca taggagtatt
     7441 atttatacaa taaaaaagaa taaacataaa ggaggctttg ttatgaataa gatgaagaag
     7501 gtgttgatga cgatgtttgg tttagtgatg ctccccctac tatttgcttg tagtaacaat
     7561 caatcggctg gaattgaagc catcaagtcc aaaggaaaat tggttgtagc cctcaatcca
     7621 gattttgctc catttgaata tcaaaaagtg gttgatggga aaaatcagat tgtgggttca
     7681 gatatcgaat tagccaaggc tatcgcaaca gaactaggtg tcgaattgga actatctcct
     7741 atgagttttg acaatgtact ggctagcgtt caatcaggaa aagctgacct tgccatatca
     7801 ggtgtttcta agacagatga acggagcaag gtgtttgatt tttcaactcc ctactatact
     7861 gcaaaaaata aactcattgt caaaaaatct gatttagcca cttatcagtc tgtcaacgat
     7921 ttggcgcaga aaaaggtcgg agcgcagaaa ggttcgattc aagagacgat ggcgaaagat
     7981 ttgctacaaa attcttccct cgtatctctg cctaaaaatg ggaatttaat cacagattta
     8041 aaatcaggac aagtggatgc cgttatcttt gaagaacctg tttccaaggg atttgtggaa
     8101 aataatcctg atttagcaat cgcagacctc aattttgaaa aagagcaaga tgattcctac
     8161 gcggtagcca tgaaaaaaga tagcaaggaa ttgaaagagg cagtcgataa aaccattcaa
     8221 aagttgaagg agtctgggga attagacaaa ctcattgagg atgcctttaa agcatccatt
     8281 gaaaaatag
//
