LOCUS       NZ_CP020549.1          14022 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  NZ_CP020549.1 Streptococcus pneumoniae strain Hu17 chromosome.
ACCESSION   NZ_CP020549
VERSION     NZ_CP020549.1
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 6.1.1
            Run date     :: 2024-03-14 13:01:09
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 68098
            Orig. end    :: 82120
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     CDS             1..1170
                     /NRPS_PKS="Domain: Aminotran_1_2 (31-382). E-value:
                     3.6e-64. Score: 209.0. Matches aSDomain:
                     nrpspksdomains_ctg1_77_Aminotran_1_2.1"
                     /NRPS_PKS="type: other"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) DegT_DnrJ_EryC1"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1019:aminotransferase (Score: 285; E-value: 1.5e-86)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg1_77"
                     /sec_met_domain="DegT_DnrJ_EryC1 (E-value: 1.8e-07,
                     bitscore: 27.7, seeds: 38, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDLTKRFNKQLDKIQVSLIRQFDQVISEIPGVLRLTLGEPDFTTP
                     DHVKEAAKRAIDQNQSYYTGMSGLLTLRQAASDFVKEKYQLDYAPENEILVTIGATEAL
                     SATLTAILEEGDKVLLPAPAYPGYEPIVNLVGAEIVEIDTTENGFVLTPEMLEKAILEQ
                     GDKLKAVILNYPANPTGITYSREQLEALAAVLRKYEIFVVCDEVYSELTYTGEAHVSLG
                     TMLRDQAIIINGLSKSHAMTGWRLGLIFAPAAFTAQLIKSHQYLVTAANTMAQHAAVEA
                     LTAGKNDAEPMKKEYIQRRDYIIEKMTALGFEIIKPDGAFYIFAKIPAGYNQDSFAFLK
                     DFAQKKAVAFIPGAAFGRYGEGYVRLSYAASMETIKEAMKRLEEYMREA"
     protocluster    1..14022
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[71947:79881]"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193)"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      3850..11783
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193)"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
     cand_cluster    1..14022
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193)"
                     /kind="single"
                     /product="RiPP-like"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..14022
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="RiPP-like"
                     /region_number="1"
                     /rules="(strepbact or Antimicrobial14 or Bacteriocin_IId or
                     BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or
                     Lactococcin or Antimicrobial17 or Lactococcin_972 or
                     Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or
                     TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or
                     TIGR03975 or DUF692 or TIGR01193)"
                     /tool="antismash"
     aSDomain        94..1146
                     /aSDomain="Aminotran_1_2"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg1_77_Aminotran_1_2.1"
                     /evalue="3.60E-64"
                     /label="ctg1_77_Aminotran_1_2.1"
                     /locus_tag="ctg1_77"
                     /protein_end="382"
                     /protein_start="31"
                     /score="209.0"
                     /tool="antismash"
                     /translation="VLRLTLGEPDFTTPDHVKEAAKRAIDQNQSYYTGMSGLLTLRQAA
                     SDFVKEKYQLDYAPENEILVTIGATEALSATLTAILEEGDKVLLPAPAYPGYEPIVNLV
                     GAEIVEIDTTENGFVLTPEMLEKAILEQGDKLKAVILNYPANPTGITYSREQLEALAAV
                     LRKYEIFVVCDEVYSELTYTGEAHVSLGTMLRDQAIIINGLSKSHAMTGWRLGLIFAPA
                     AFTAQLIKSHQYLVTAANTMAQHAAVEALTAGKNDAEPMKKEYIQRRDYIIEKMTALGF
                     EIIKPDGAFYIFAKIPAGYNQDSFAFLKDFAQKKAVAFIPGAAFGRYGEGYVRLSYAAS
                     METIKEAMKRL"
     PFAM_domain     94..1146
                     /aSDomain="Aminotran_1_2"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00155.23"
                     /description="Aminotransferase class I and II"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_77_0001"
                     /evalue="1.10E-61"
                     /label="ctg1_77"
                     /locus_tag="ctg1_77"
                     /protein_end="382"
                     /protein_start="31"
                     /score="209.2"
                     /tool="antismash"
                     /translation="VLRLTLGEPDFTTPDHVKEAAKRAIDQNQSYYTGMSGLLTLRQAA
                     SDFVKEKYQLDYAPENEILVTIGATEALSATLTAILEEGDKVLLPAPAYPGYEPIVNLV
                     GAEIVEIDTTENGFVLTPEMLEKAILEQGDKLKAVILNYPANPTGITYSREQLEALAAV
                     LRKYEIFVVCDEVYSELTYTGEAHVSLGTMLRDQAIIINGLSKSHAMTGWRLGLIFAPA
                     AFTAQLIKSHQYLVTAANTMAQHAAVEALTAGKNDAEPMKKEYIQRRDYIIEKMTALGF
                     EIIKPDGAFYIFAKIPAGYNQDSFAFLKDFAQKKAVAFIPGAAFGRYGEGYVRLSYAAS
                     METIKEAMKRL"
     CDS             1167..1937
                     /locus_tag="ctg1_78"
                     /transl_table=11
                     /translation="MIQSITSQGLVLYNRNFREDDKLVKIFTEQVGKRMFFVKHAGQSK
                     LAPVIQPLVLARFLLRINDDGLSYIEDYHEVMTFPKINSDLFVMAYATYVAALADASLQ
                     DNQQDAPLFAFLQKTLELMEAGLDYQVLTNIFEIQILTRFGISLNFNECVFCHRVGQAF
                     DFSFKYGACLCPEHYHEDKRRCHLNPNIPYLLNQFQAIDFETLETISLKPGIKQELRQF
                     MDQLYEEYVGIHLKSKKFIDSLADWGQLLKEEKK"
     PFAM_domain     1176..1382
                     /aSDomain="RecO_N"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF11967.10"
                     /description="Recombination protein O N terminal"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_78_0002"
                     /evalue="8.40E-16"
                     /label="ctg1_78"
                     /locus_tag="ctg1_78"
                     /protein_end="72"
                     /protein_start="3"
                     /score="57.8"
                     /tool="antismash"
                     /translation="SITSQGLVLYNRNFREDDKLVKIFTEQVGKRMFFVKHAGQSKLAP
                     VIQPLVLARFLLRINDDGLSYIED"
     aSDomain        1182..1895
                     /aSDomain="TIGR00613"
                     /aSTool="tigrfam"
                     /description="reco: DNA repair protein RecO"
                     /detection="hmmscan"
                     /domain_id="TIGRFam_ctg1_78_0001"
                     /evalue="1.30E-71"
                     /identifier="TIGR00613"
                     /label="ctg1_78"
                     /locus_tag="ctg1_78"
                     /protein_end="243"
                     /protein_start="5"
                     /score="238.8"
                     /tool="antismash"
                     /translation="TSQGLVLYNRNFREDDKLVKIFTEQVGKRMFFVKHAGQSKLAPVI
                     QPLVLARFLLRINDDGLSYIEDYHEVMTFPKINSDLFVMAYATYVAALADASLQDNQQD
                     APLFAFLQKTLELMEAGLDYQVLTNIFEIQILTRFGISLNFNECVFCHRVGQAFDFSFK
                     YGACLCPEHYHEDKRRCHLNPNIPYLLNQFQAIDFETLETISLKPGIKQELRQFMDQLY
                     EEYVGIHLKSKKFIDS"
     PFAM_domain     1416..1880
                     /aSDomain="RecO_C"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF02565.17"
                     /description="Recombination protein O C terminal"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_78_0003"
                     /evalue="1.80E-35"
                     /label="ctg1_78"
                     /locus_tag="ctg1_78"
                     /protein_end="238"
                     /protein_start="83"
                     /score="122.1"
                     /tool="antismash"
                     /translation="SDLFVMAYATYVAALADASLQDNQQDAPLFAFLQKTLELMEAGLD
                     YQVLTNIFEIQILTRFGISLNFNECVFCHRVGQAFDFSFKYGACLCPEHYHEDKRRCHL
                     NPNIPYLLNQFQAIDFETLETISLKPGIKQELRQFMDQLYEEYVGIHLKSK"
     CDS             1934..2926
                     /locus_tag="ctg1_79"
                     /transl_table=11
                     /translation="MKKIAVDAMGGDYAPQAIVEGVNQALSDFSDIEVQLYGDEAKIKQ
                     YLTATERVSIIHTDEKIDSDDEPTRAIRNKKNASMVLAAKAVKDGEADAVLSAGNTGAL
                     LAAGFFIVGRIKNIDRPGLMSTLPTVDGKGFDMLDLGANAENTAQHLHQYAVLGSFYAK
                     NVRGIAQPRVGLLNNGTESSKGDPLRKETYELLAADESLNFIGNVEARDLMNGVADVVV
                     ADGFTGNAVLKSIEGTAMGIMGLLKTAITGGGLRAKLGALLLKDSLRGLKKQLNYSDVG
                     GAVLFGVKAPVVKTHGSSDAKAVYSTIRQIRTMLETDVVAQTAREFSGE"
     PFAM_domain     1940..2893
                     /aSDomain="FA_synthesis"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF02504.17"
                     /description="Fatty acid synthesis protein"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_79_0004"
                     /evalue="6.00E-105"
                     /label="ctg1_79"
                     /locus_tag="ctg1_79"
                     /protein_end="320"
                     /protein_start="2"
                     /score="351.0"
                     /tool="antismash"
                     /translation="KIAVDAMGGDYAPQAIVEGVNQALSDFSDIEVQLYGDEAKIKQYL
                     TATERVSIIHTDEKIDSDDEPTRAIRNKKNASMVLAAKAVKDGEADAVLSAGNTGALLA
                     AGFFIVGRIKNIDRPGLMSTLPTVDGKGFDMLDLGANAENTAQHLHQYAVLGSFYAKNV
                     RGIAQPRVGLLNNGTESSKGDPLRKETYELLAADESLNFIGNVEARDLMNGVADVVVAD
                     GFTGNAVLKSIEGTAMGIMGLLKTAITGGGLRAKLGALLLKDSLRGLKKQLNYSDVGGA
                     VLFGVKAPVVKTHGSSDAKAVYSTIRQIRTMLETDVV"
     aSDomain        1940..2914
                     /aSDomain="TIGR00182"
                     /aSTool="tigrfam"
                     /description="plsX: fatty acid/phospholipid synthesis
                     protein PlsX"
                     /detection="hmmscan"
                     /domain_id="TIGRFam_ctg1_79_0002"
                     /evalue="1.40E-116"
                     /identifier="TIGR00182"
                     /label="ctg1_79"
                     /locus_tag="ctg1_79"
                     /protein_end="327"
                     /protein_start="2"
                     /score="387.3"
                     /tool="antismash"
                     /translation="KIAVDAMGGDYAPQAIVEGVNQALSDFSDIEVQLYGDEAKIKQYL
                     TATERVSIIHTDEKIDSDDEPTRAIRNKKNASMVLAAKAVKDGEADAVLSAGNTGALLA
                     AGFFIVGRIKNIDRPGLMSTLPTVDGKGFDMLDLGANAENTAQHLHQYAVLGSFYAKNV
                     RGIAQPRVGLLNNGTESSKGDPLRKETYELLAADESLNFIGNVEARDLMNGVADVVVAD
                     GFTGNAVLKSIEGTAMGIMGLLKTAITGGGLRAKLGALLLKDSLRGLKKQLNYSDVGGA
                     VLFGVKAPVVKTHGSSDAKAVYSTIRQIRTMLETDVVAQTAREF"
     CDS             2932..3165
                     /NRPS_PKS="Domain: PP-binding (8-72). E-value: 4.2e-12.
                     Score: 38.3. Matches aSDomain:
                     nrpspksdomains_ctg1_80_PP-binding.1"
                     /NRPS_PKS="type: other"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PP-binding"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg1_80"
                     /sec_met_domain="PP-binding (E-value: 1.6e-10, bitscore:
                     38.3, seeds: 164, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTEKEIFDRIVTIIQERQGEDFVVTESLSLKDDLDADSVDLMEFI
                     LTLEDEFSIEISDEEIDQLQNVGDVVKIIQGK"
     aSDomain        2956..3147
                     /aSDomain="PP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg1_80_PP-binding.1"
                     /evalue="4.20E-12"
                     /label="ctg1_80_PP-binding.1"
                     /locus_tag="ctg1_80"
                     /protein_end="72"
                     /protein_start="8"
                     /score="38.3"
                     /tool="antismash"
                     /translation="RIVTIIQERQGEDFVVTESLSLKDDLDADSVDLMEFILTLEDEFS
                     IEISDEEIDQLQNVGDVVK"
     PFAM_domain     2956..3147
                     /aSDomain="PP-binding"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00550.27"
                     /description="Phosphopantetheine attachment site"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_80_0005"
                     /evalue="7.50E-09"
                     /label="ctg1_80"
                     /locus_tag="ctg1_80"
                     /protein_end="72"
                     /protein_start="8"
                     /score="35.9"
                     /tool="antismash"
                     /translation="RIVTIIQERQGEDFVVTESLSLKDDLDADSVDLMEFILTLEDEFS
                     IEISDEEIDQLQNVGDVVK"
     CDS             3195..3698
                     /locus_tag="ctg1_81"
                     /transl_table=11
                     /translation="MVFRNEKXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
                     XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
                     XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXSKKVIR
                     KHLF"
     CDS             3850..4080
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: Bacteriocin_IIc"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg1_82"
                     /sec_met_domain="Bacteriocin_IIc (E-value: 6.2e-16,
                     bitscore: 55.5, seeds: 35, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNTKKMSQFEIMDTEMLACVEGGGCNWGDFAKAGVGGGAVRGLQL
                     GIKTRTWQGAATGAAGGAILGGVAYAATCWW"
     PFAM_domain     3865..4044
                     /aSDomain="Bacteriocin_IIc"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF10439.11"
                     /description="Bacteriocin class II with double-glycine
                     leader peptide"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_82_0006"
                     /evalue="2.10E-15"
                     /label="ctg1_82"
                     /locus_tag="ctg1_82"
                     /protein_end="65"
                     /protein_start="5"
                     /score="56.6"
                     /tool="antismash"
                     /translation="MSQFEIMDTEMLACVEGGGCNWGDFAKAGVGGGAVRGLQLGIKTR
                     TWQGAATGAAGGAIL"
     CDS             4083..4208
                     /locus_tag="ctg1_83"
                     /transl_table=11
                     /translation="MDFKSFIIGLVVGIFGPYMDDLIRKKFLKSSEKKTEKSVKK"
     CDS             4831..5724
                     /locus_tag="ctg1_84"
                     /transl_table=11
                     /translation="MDELKREIGYKIKTIRRSCGKTQIDICGDESELTIRQLARIENGQ
                     ALATLPKLLLIADKLGVSLQNIVDVKVIEIPKGFLKLKDELIHSQTYADKGRIERKEAI
                     LEEIYENYYENLPEEEQLIVDVTQARFDIYGSSDVTYGLGLVEEYFQQLLKKKYFSVND
                     LLIIELYFFCCAMGLEDKEHFEELAQKVLLCSEYEDKASLVQMEKVLLSLFIQIQTEDS
                     LIYIQTFEKIIAKTRHVFYRPHLFLLKAKYALFVDKNILEAESFYEKAISLAELLDDQV
                     LVQRILAEKQIDFPTT"
     PFAM_domain     5056..5697
                     /aSDomain="ComR_TPR"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF18710.3"
                     /description="ComR tetratricopeptide"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_84_0007"
                     /evalue="1.30E-58"
                     /label="ctg1_84"
                     /locus_tag="ctg1_84"
                     /protein_end="289"
                     /protein_start="75"
                     /score="198.3"
                     /tool="antismash"
                     /translation="PKGFLKLKDELIHSQTYADKGRIERKEAILEEIYENYYENLPEEE
                     QLIVDVTQARFDIYGSSDVTYGLGLVEEYFQQLLKKKYFSVNDLLIIELYFFCCAMGLE
                     DKEHFEELAQKVLLCSEYEDKASLVQMEKVLLSLFIQIQTEDSLIYIQTFEKIIAKTRH
                     VFYRPHLFLLKAKYALFVDKNILEAESFYEKAISLAELLDDQVLVQRILAE"
     CDS             6267..6563
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: Bacteriocin_IId"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg1_85"
                     /sec_met_domain="Bacteriocin_IId (E-value: 6.8e-21,
                     bitscore: 71.2, seeds: 5, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKSKRMEFHNKFLIVSAMLAVISWLSLGVVSFPMLAGTLGISTKA
                     AATVVNLISAYSTVTAVISIVGAITGVGSIGSGIAATVLYILKKKGAAKAALW"
     aSDomain        6369..6560
                     /aSDomain="TIGR03651"
                     /aSTool="tigrfam"
                     /description="circ_ocin_uber: circular bacteriocin,
                     circularin A/uberolysin family"
                     /detection="hmmscan"
                     /domain_id="TIGRFam_ctg1_85_0003"
                     /evalue="3.40E-15"
                     /identifier="TIGR03651"
                     /label="ctg1_85"
                     /locus_tag="ctg1_85"
                     /protein_end="98"
                     /protein_start="34"
                     /score="54.1"
                     /tool="antismash"
                     /translation="LAGTLGISTKAAATVVNLISAYSTVTAVISIVGAITGVGSIGSGI
                     AATVLYILKKKGAAKAALW"
     PFAM_domain     6372..6560
                     /aSDomain="Bacteriocin_IId"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF09221.12"
                     /description="Bacteriocin class IId cyclical
                     uberolysin-like"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_85_0008"
                     /evalue="3.00E-15"
                     /label="ctg1_85"
                     /locus_tag="ctg1_85"
                     /protein_end="98"
                     /protein_start="35"
                     /score="56.2"
                     /tool="antismash"
                     /translation="AGTLGISTKAAATVVNLISAYSTVTAVISIVGAITGVGSIGSGIA
                     ATVLYILKKKGAAKAALW"
     CDS             6570..7706
                     /locus_tag="ctg1_86"
                     /transl_table=11
                     /translation="MKILSKKECESILGYLNFIGITLLFFVIISLSIYFKSYLPFQGKL
                     FLLFLVVDYATLNRYNMKLPIQSKKINTFYIRKNYIFLYLLAIVKKYYSFQILQSFIYL
                     FILYFLDIIGYFYLSITLCLIAIQIISLILPSLFSIISKLFLFLSIGLLSIEQGQVVIY
                     VILLNYFILVMGILDNHASNFYFKSSRMSQKRFRSSLFILLRFCWLNKGLTFSFILISI
                     LLSYLFWYMMTMLSIDDTKIPILFLYTSIYITLMEAIIGNHKSSIGVDLALLQLSALNH
                     SKMNFFFKNAQLMMLTHLISFLQFSLLLCLIPVTSYSNDIKSILLNLLLIPFNYFIAYV
                     YYKKALFLIKGTVSLLRWSFLVLYCFLIIFVILVGGIR"
     CDS             7703..8185
                     /locus_tag="ctg1_87"
                     /transl_table=11
                     /translation="MRKSGFLIYYVLFCIVCFLLGLLLSFILKNETFATIPPKLELQFT
                     LTVLQANSTNFLLYLFCFPISPLLQLFDLLSLGIQLGISGQMIGIVATIKGILPHALIE
                     IPNFIWYQGMSQYLLYRLLKDRGIKNILIYIKSNLKWYIISYLLLILAALIEGIKL"
     PFAM_domain     7745..8173
                     /aSDomain="SpoIIM"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF01944.19"
                     /description="Stage II sporulation protein M"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_87_0009"
                     /evalue="4.60E-09"
                     /label="ctg1_87"
                     /locus_tag="ctg1_87"
                     /protein_end="157"
                     /protein_start="14"
                     /score="36.6"
                     /tool="antismash"
                     /translation="IVCFLLGLLLSFILKNETFATIPPKLELQFTLTVLQANSTNFLLY
                     LFCFPISPLLQLFDLLSLGIQLGISGQMIGIVATIKGILPHALIEIPNFIWYQGMSQYL
                     LYRLLKDRGIKNILIYIKSNLKWYIISYLLLILAALIEG"
     CDS             8182..8778
                     /gene_functions="transport (smcogs) SMCOG1000:ABC
                     transporter ATP-binding protein (Score: 69.4; E-value:
                     6.3e-21)"
                     /gene_kind="transport"
                     /locus_tag="ctg1_88"
                     /transl_table=11
                     /translation="MKIENESKSYDKCILKNISLEIDKGIYRVEGENGSGKSTLLQLLA
                     GLETFDSGLKNCVSKDVLYLDTNQLGVVPFTIEENLQLLCDSFQIHLSFEDKEQINTFF
                     DNKIGDNYMTASTGTKFKLGLSLIFAKNWDYIFIDETLSTVDARSIDMIAKRLISMKES
                     STIIYVSHNLLNQELISKSQRILIEEGRVYEISNK"
     PFAM_domain     8224..8604
                     /aSDomain="ABC_tran"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00005.29"
                     /description="ABC transporter"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_88_0010"
                     /evalue="1.20E-08"
                     /label="ctg1_88"
                     /locus_tag="ctg1_88"
                     /protein_end="141"
                     /protein_start="14"
                     /score="35.7"
                     /tool="antismash"
                     /translation="LKNISLEIDKGIYRVEGENGSGKSTLLQLLAGLETFDSGLKNCVS
                     KDVLYLDTNQLGVVPFTIEENLQLLCDSFQIHLSFEDKEQINTFFDNKIGDNYMTASTG
                     TKFKLGLSLIFAKNWDYIFIDET"
     CDS             8759..9250
                     /locus_tag="ctg1_89"
                     /transl_table=11
                     /translation="MKFQTNNSLYKLMNLIIYLFLLYLFIDLLMKSGILDEQIDKLSEL
                     SNLFTIKIETILTVISVVFTFIATLIEYGFSLFLITLFFDKNKRNFGDILLSKNITLSF
                     SILLCYLFNPSDIKFAYFSVLTVLLIGITNYARFKNLRLTVVFSVPFLFNAIMSIINSF
                     "
     CDS             9630..11783
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: TIGR01193"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_C39"
                     /gene_functions="transport (smcogs) SMCOG1288:ABC
                     transporter related protein (Score: 336.3; E-value:
                     6e-102)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg1_90"
                     /sec_met_domain="TIGR01193 (E-value: 0.0, bitscore: 1124.1,
                     seeds: 5, tool: rule-based-clusters)"
                     /sec_met_domain="Peptidase_C39 (E-value: 4.4e-42, bitscore:
                     140.0, seeds: 36, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKFGKRHYRPQVDQMDCGVASLAMVFGYYGSYYFLAHLRELAKTT
                     MDGTTALGLVKVAEEIGFETRAIKADMTLFDLPDLTFPFVAHVLKEGKLLHYYVVTGQD
                     KDSIHIADPDPGVKLTKLPRERFEEEWTGVTLFMAPSPDYKPHKDQKNGLLSFIPILVK
                     QRGLIANIVLATLLVTLINIVGSYYLQSIIDTYVPDQMRSTLGIISIGLVIVYILQQIL
                     SYAQEYLLLVLGQRLSIDVILSYIKHVFHLPMSFFATRRTGEIVSRFTDANSIIDALAS
                     TILSIFLDVSTVVIISLVLFSQNTNLFFMTLLALPIYTVIIFAFMKPFEKMNRDTMEAN
                     AVLSSSIIEDINGIETIKSLTSESQRYQKIDKEFVDYLKKSFTYSRAESQQKALKKVAH
                     LLLNVGILWMGAVLVMDGKMSLGQLITYNTLLVYFTNPLENIINLQTKLQTAQVANNRL
                     NEVYLVASEFEEKKTVEDLSLMKGEMTFKQVHYKYGYGRDVLSDINLTVPQGSKVAFVG
                     ISGSGKTTLAKMMVNFYDPSQGEISLGGVNLNQIDKKALRQYINYLPQQPYVFNGTILE
                     NLLLGAKEGTTQEDILRAVELAEIREDIERMPLNYQTELTSDGAGISGGQRQRIALARA
                     LLTDAPVLILDEATSSLDILTEKRIVDNLIALDKTLIFIAHRLTIAERTEKVVVLDQGK
                     IVEEGKHADLLAQGGFYAHLVNS"
     PFAM_domain     9648..10055
                     /aSDomain="Peptidase_C39"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF03412.17"
                     /description="Peptidase C39 family"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_90_0011"
                     /evalue="4.00E-41"
                     /label="ctg1_90"
                     /locus_tag="ctg1_90"
                     /protein_end="142"
                     /protein_start="6"
                     /score="140.0"
                     /tool="antismash"
                     /translation="HYRPQVDQMDCGVASLAMVFGYYGSYYFLAHLRELAKTTMDGTTA
                     LGLVKVAEEIGFETRAIKADMTLFDLPDLTFPFVAHVLKEGKLLHYYVVTGQDKDSIHI
                     ADPDPGVKLTKLPRERFEEEWTGVTLFMAPSP"
     aSDomain        9660..11777
                     /aSDomain="TIGR01193"
                     /aSTool="tigrfam"
                     /description="bacteriocin_ABC: ABC-type bacteriocin
                     transporter"
                     /detection="hmmscan"
                     /domain_id="TIGRFam_ctg1_90_0004"
                     /evalue="0.00E+00"
                     /identifier="TIGR01193"
                     /label="ctg1_90"
                     /locus_tag="ctg1_90"
                     /protein_end="716"
                     /protein_start="10"
                     /score="1124.1"
                     /tool="antismash"
                     /translation="QVDQMDCGVASLAMVFGYYGSYYFLAHLRELAKTTMDGTTALGLV
                     KVAEEIGFETRAIKADMTLFDLPDLTFPFVAHVLKEGKLLHYYVVTGQDKDSIHIADPD
                     PGVKLTKLPRERFEEEWTGVTLFMAPSPDYKPHKDQKNGLLSFIPILVKQRGLIANIVL
                     ATLLVTLINIVGSYYLQSIIDTYVPDQMRSTLGIISIGLVIVYILQQILSYAQEYLLLV
                     LGQRLSIDVILSYIKHVFHLPMSFFATRRTGEIVSRFTDANSIIDALASTILSIFLDVS
                     TVVIISLVLFSQNTNLFFMTLLALPIYTVIIFAFMKPFEKMNRDTMEANAVLSSSIIED
                     INGIETIKSLTSESQRYQKIDKEFVDYLKKSFTYSRAESQQKALKKVAHLLLNVGILWM
                     GAVLVMDGKMSLGQLITYNTLLVYFTNPLENIINLQTKLQTAQVANNRLNEVYLVASEF
                     EEKKTVEDLSLMKGEMTFKQVHYKYGYGRDVLSDINLTVPQGSKVAFVGISGSGKTTLA
                     KMMVNFYDPSQGEISLGGVNLNQIDKKALRQYINYLPQQPYVFNGTILENLLLGAKEGT
                     TQEDILRAVELAEIREDIERMPLNYQTELTSDGAGISGGQRQRIALARALLTDAPVLIL
                     DEATSSLDILTEKRIVDNLIALDKTLIFIAHRLTIAERTEKVVVLDQGKIVEEGKHADL
                     LAQGGFYAHLVN"
     PFAM_domain     10137..10943
                     /aSDomain="ABC_membrane"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00664.25"
                     /description="ABC transporter transmembrane region"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_90_0012"
                     /evalue="2.00E-62"
                     /label="ctg1_90"
                     /locus_tag="ctg1_90"
                     /protein_end="438"
                     /protein_start="169"
                     /score="211.4"
                     /tool="antismash"
                     /translation="NIVLATLLVTLINIVGSYYLQSIIDTYVPDQMRSTLGIISIGLVI
                     VYILQQILSYAQEYLLLVLGQRLSIDVILSYIKHVFHLPMSFFATRRTGEIVSRFTDAN
                     SIIDALASTILSIFLDVSTVVIISLVLFSQNTNLFFMTLLALPIYTVIIFAFMKPFEKM
                     NRDTMEANAVLSSSIIEDINGIETIKSLTSESQRYQKIDKEFVDYLKKSFTYSRAESQQ
                     KALKKVAHLLLNVGILWMGAVLVMDGKMSLGQLITYNTLLVYFTNPL"
     PFAM_domain     11127..11579
                     /aSDomain="ABC_tran"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00005.29"
                     /description="ABC transporter"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_90_0013"
                     /evalue="1.10E-31"
                     /label="ctg1_90"
                     /locus_tag="ctg1_90"
                     /protein_end="650"
                     /protein_start="499"
                     /score="110.3"
                     /tool="antismash"
                     /translation="LSDINLTVPQGSKVAFVGISGSGKTTLAKMMVNFYDPSQGEISLG
                     GVNLNQIDKKALRQYINYLPQQPYVFNGTILENLLLGAKEGTTQEDILRAVELAEIRED
                     IERMPLNYQTELTSDGAGISGGQRQRIALARALLTDAPVLILDEATS"
     aSDomain        11796..13142
                     /aSDomain="TIGR01000"
                     /aSTool="tigrfam"
                     /description="bacteriocin_acc: bacteriocin secretion
                     accessory protein"
                     /detection="hmmscan"
                     /domain_id="TIGRFam_ctg1_91_0005"
                     /evalue="5.70E-174"
                     /identifier="TIGR01000"
                     /label="ctg1_91"
                     /locus_tag="ctg1_91"
                     /protein_end="449"
                     /protein_start="0"
                     /score="577.2"
                     /tool="antismash"
                     /translation="MKPEFLESAEFYNRRYHNFSSSVIVPMALLLVFLLGFATVAEKEM
                     SLSTRATVEPSRILANIQSTSNNRILVNHLEENKLVKKGDLLVQYQEGAEGVQAESYAS
                     QLDMLKDQKKQLEYLQKSLQEGENHFPEEDKFGYQATFRDYISQVGSLRASTSQQNETI
                     ASQNAAASQTQAEIGNLISQTEAKIRDYQTVKSAIETGASLAGQNLAYSLYQSYKSQGE
                     ENPQTKVQAVAQVEAQISQLESSLATYRVQYAGSGTQQAYASGLSSQLESLKSQHLAKV
                     GQELTLLAQKILEAESGKKVQGNLLDKGKITASEDGVLHLNPETSDSSMVAEGALLAQL
                     YPSLEREGKAKLTAYLSSKDVARIKVGDSVRYTTTHDAGNQLFLDSTITSIDATATKTE
                     KGNFFKIEAEINLTSEQAEKLRYGVEGRLQMITGKKSYLRYYLDQFLNKE"
     CDS             11796..13145
                     /locus_tag="ctg1_91"
                     /transl_table=11
                     /translation="MKPEFLESAEFYNRRYHNFSSSVIVPMALLLVFLLGFATVAEKEM
                     SLSTRATVEPSRILANIQSTSNNRILVNHLEENKLVKKGDLLVQYQEGAEGVQAESYAS
                     QLDMLKDQKKQLEYLQKSLQEGENHFPEEDKFGYQATFRDYISQVGSLRASTSQQNETI
                     ASQNAAASQTQAEIGNLISQTEAKIRDYQTVKSAIETGASLAGQNLAYSLYQSYKSQGE
                     ENPQTKVQAVAQVEAQISQLESSLATYRVQYAGSGTQQAYASGLSSQLESLKSQHLAKV
                     GQELTLLAQKILEAESGKKVQGNLLDKGKITASEDGVLHLNPETSDSSMVAEGALLAQL
                     YPSLEREGKAKLTAYLSSKDVARIKVGDSVRYTTTHDAGNQLFLDSTITSIDATATKTE
                     KGNFFKIEAEINLTSEQAEKLRYGVEGRLQMITGKKSYLRYYLDQFLNKE"
     PFAM_domain     12723..13064
                     /aSDomain="HlyD_3"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF13437.8"
                     /description="HlyD family secretion protein"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_91_0014"
                     /evalue="8.10E-10"
                     /label="ctg1_91"
                     /locus_tag="ctg1_91"
                     /protein_end="423"
                     /protein_start="309"
                     /score="39.4"
                     /tool="antismash"
                     /translation="KITASEDGVLHLNPETSDSSMVAEGALLAQLYPSLEREGKAKLTA
                     YLSSKDVARIKVGDSVRYTTTHDAGNQLFLDSTITSIDATATKTEKGNFFKIEAEINLT
                     SEQAEKLRYG"
     CDS             13315..14022
                     /locus_tag="ctg1_92"
                     /transl_table=11
                     /translation="MSKQLIYSGKAKDIYTTEDENLIISTYKDQATAFNGVKKEQIAGK
                     GVLNNQISSFIFEKLNAAGVATHFVEKLSDTEQLNKKVKIIPLEVVLRNYTAGSFSKRF
                     GVDEGIALETPIVEFYYKNDDLDDPFINDEHVKFLQIADDQQIAYLKEETRRINELLKV
                     WFAEIGLKLIDFKLEFGFDKDGKIILADEFSPDNCRLWDADGNHMDKDVFRRGLGELTD
                     VYEIVWEKLQELK"
     aSDomain        13324..13926
                     /aSDomain="TIGR00081"
                     /aSTool="tigrfam"
                     /description="purC:
                     phosphoribosylaminoimidazolesuccinocarboxamide synthase"
                     /detection="hmmscan"
                     /domain_id="TIGRFam_ctg1_92_0006"
                     /evalue="9.20E-72"
                     /identifier="TIGR00081"
                     /label="ctg1_92"
                     /locus_tag="ctg1_92"
                     /protein_end="204"
                     /protein_start="3"
                     /score="239.7"
                     /tool="antismash"
                     /translation="QLIYSGKAKDIYTTEDENLIISTYKDQATAFNGVKKEQIAGKGVL
                     NNQISSFIFEKLNAAGVATHFVEKLSDTEQLNKKVKIIPLEVVLRNYTAGSFSKRFGVD
                     EGIALETPIVEFYYKNDDLDDPFINDEHVKFLQIADDQQIAYLKEETRRINELLKVWFA
                     EIGLKLIDFKLEFGFDKDGKIILADEFSPDNCRLWDAD"
     PFAM_domain     13330..13992
                     /aSDomain="SAICAR_synt"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF01259.20"
                     /description="SAICAR synthetase"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_92_0015"
                     /evalue="2.20E-66"
                     /label="ctg1_92"
                     /locus_tag="ctg1_92"
                     /protein_end="226"
                     /protein_start="5"
                     /score="224.1"
                     /tool="antismash"
                     /translation="IYSGKAKDIYTTEDENLIISTYKDQATAFNGVKKEQIAGKGVLNN
                     QISSFIFEKLNAAGVATHFVEKLSDTEQLNKKVKIIPLEVVLRNYTAGSFSKRFGVDEG
                     IALETPIVEFYYKNDDLDDPFINDEHVKFLQIADDQQIAYLKEETRRINELLKVWFAEI
                     GLKLIDFKLEFGFDKDGKIILADEFSPDNCRLWDADGNHMDKDVFRRGLGELTDVYEI"
ORIGIN
        1 atggacttaa ctaagcgctt taataaacag ttagataaaa ttcaagtttc gttgattcgt
       61 cagtttgacc aggttatttc ggagattcct ggggtcttgc gtttgacctt gggggaacct
      121 gattttacaa cgccagacca tgtcaaggag gcggccaagc gagcgattga tcagaaccaa
      181 tcctactata cagggatgag tggtctgctg actctacgtc aggcagctag tgactttgtt
      241 aaggaaaagt accaactgga ctatgctcct gaaaatgaaa tcttggttac aattggggcg
      301 acagaggctt tatctgcgac tttgacggct attttggaag agggagacaa ggtgctcttg
      361 ccagctcctg cttatccggg ttatgaaccg attgtcaatc tagttggggc agaaattgtt
      421 gagattgata cgactgaaaa tggttttgtc ttgactcctg agatgttgga gaaggccatt
      481 ttggagcagg gtgataagct caaggcggtt attctcaact atccagccaa tccgacagga
      541 attacctaca gtcgagagca gttagaggcc ttggcagctg ttttacgcaa gtacgaaatt
      601 tttgttgtct gtgatgaggt ttactcagaa ttgacctaca caggcgaagc ccatgtgtct
      661 ctaggaacga tgttgagaga ccaggctatt attatcaatg gtttgtctaa atcgcatgcc
      721 atgacaggtt ggcgtttggg gctgattttc gctcctgcgg ccttcacagc ccagttaatc
      781 aagagtcacc aatacttggt cactgccgca aataccatgg cgcaacatgc tgcggtagaa
      841 gccttgacgg ctggtaaaaa tgatgcggag cccatgaaga aggaatatat ccagcgtcgg
      901 gactatatca tcgaaaaaat gactgctctt ggttttgaga ttatcaaacc agacggtgcc
      961 ttctatattt ttgctaaaat tccagcgggc tacaatcaag actcctttgc ttttctgaag
     1021 gattttgctc agaagaaggc cgttgccttt atccctggtg cagcctttgg acgttacggg
     1081 gaaggctacg tccgcctatc ttatgcagcc agcatggaga ctatcaaaga agccatgaaa
     1141 cgacttgagg agtacatgag agaagcatga ttcagtctat cacgagtcaa ggcttggtgc
     1201 tttacaatcg caattttcgt gaggatgaca agctcgtcaa aatttttaca gagcaggttg
     1261 gcaaacgcat gttttttgtc aaacacgctg gtcagtctaa gctggcgcct gttattcagc
     1321 ccttggtgct ggcacgattt ctcttgcgaa tcaatgatga cggactcagt tacatcgaag
     1381 actatcatga ggtcatgact tttcccaaga ttaatagtga cctctttgtc atggcctatg
     1441 cgacctatgt ggcagctctt gcagatgcta gtttgcagga caatcagcag gatgctccct
     1501 tgtttgcttt tttgcaaaag actttggagt tgatggaagc aggcttggat tatcaggttt
     1561 tgaccaatat ttttgaaatt caaattttga ctcgatttgg aatcagcctc aattttaatg
     1621 agtgtgtctt ctgccatcgg gttggtcagg cttttgactt ttctttcaaa tatggagcct
     1681 gcctctgtcc agagcattat catgaggata agagacgttg tcatctcaat cccaatatcc
     1741 cctatctgct caatcaattt caagctattg attttgagac tttggagacc atttcgctca
     1801 agcctggaat caagcaagag ctacgccaat ttatggatca attatatgaa gagtacgttg
     1861 ggattcacct aaaatcaaag aaatttattg attccctagc agactgggga caattactaa
     1921 aagaggaaaa gaaatgaaaa aaatcgcagt agatgccatg gggggcgatt acgcacctca
     1981 ggccattgtt gagggtgtca atcaagccct atctgacttt tcagatatcg aggttcaact
     2041 ttacggagat gaagctaaaa tcaagcaata tctgacagcg acagagcgcg tcagcattat
     2101 ccatacggat gagaagattg attcggatga tgaacctacg agagctatta ggaataagaa
     2161 aaatgccagt atggtattgg cagccaaggc tgtcaaagat ggtgaagcag acgctgtcct
     2221 ttcggctggg aatacaggtg ccttgttggc agcaggattc ttcatcgtgg gtcgtatcaa
     2281 gaatatcgac cgtcctggac tcatgtctac cttgcctacc gttgatggaa aaggttttga
     2341 catgctagac cttggtgcca atgcagaaaa tacagcccag cacctccatc aatatgcggt
     2401 tctaggttcc ttctatgcta aaaatgtccg tggcattgcg caaccacgcg ttggtttgct
     2461 caacaacgga acagagagta gcaagggcga cccgcttcgt aaggaaactt atgaattact
     2521 ggcggctgat gaaagtttga actttatcgg aaacgtggaa gcgcgtgatt tgatgaatgg
     2581 cgttgcagat gttgttgtgg cagatggttt cacgggaaac gctgtgctca aatccatcga
     2641 agggacagct atgggaatca tgggcttgct caagacagct attacaggtg gtggtcttcg
     2701 agcgaaacta ggtgccctcc ttctcaagga cagcctcaga ggtttgaaaa aacagctcaa
     2761 ttattcagat gttggtggag cggtcttgtt tggtgttaag gcacctgttg tcaagactca
     2821 tggctcaagc gatgccaagg ctgtttatag tacgattcgt cagatccgta ccatgctaga
     2881 aacagacgtg gttgcccaga ctgcgcgtga attttcagga gaataaaaga gatgacagaa
     2941 aaagaaattt ttgaccgtat tgtgaccatt atccaagagc gacagggaga ggactttgtc
     3001 gtgacagaat ccttgagtct gaaagacgat ttggatgcgg attctgttga cttgatggag
     3061 tttatcttga ctctggaaga tgaatttagt atcgaaatca gcgatgaaga aattgaccaa
     3121 ctccaaaacg taggagatgt ggttaaaatc attcaaggaa aatagcaatc ggagttccaa
     3181 gtcaacggaa gtagatggtt tttagaaatg agaaatannn nnnnnnnnnn nnnnnnnnnn
     3241 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
     3301 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
     3361 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
     3421 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
     3481 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
     3541 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
     3601 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
     3661 nnnntagtaa aaaagtgatt agaaaacatc ttttttaaaa atagagatga ttttgaaaca
     3721 aaaaagctaa ttcaagacgt ttcgatgcca attcaagatt tggatgaaaa aaattaatag
     3781 atactgttat actaaacttg tcaagtttgt aacaagacaa atattaaaaa taaaaaagag
     3841 gtattcgtta tgaatacaaa aaagatgtca caatttgaaa ttatggatac tgagatgctt
     3901 gcttgcgttg aaggtggcgg atgcaattgg ggagattttg ccaaagcagg tgttggagga
     3961 ggagcagtac gaggtcttca gctaggaatt aaaacaagaa catggcaagg tgcagcaact
     4021 ggtgctgcgg gaggagctat acttggaggt gtggcctatg cagcgacatg ttggtggtaa
     4081 ttatggattt taaaagtttt attattggtt tagtagttgg tatatttggt ccttatatgg
     4141 atgatttaat tagaaaaaaa tttttaaagt cttcggagaa gaaaacagaa aaatctgtta
     4201 aaaaataatc aaaactataa atgatgaatc tgaatcaaaa ttattttgcg catgtaaaga
     4261 ggagtcttat agtaacgagt caaaaaagga gtaactatga atcgtaattt agaacggtgt
     4321 tatctattct gactaggaat agatcatacc agaggtagct tagaaatagc agagacatta
     4381 gaaattgaag taataaatag gatgtcgtaa gtgttactat caatgattta tttgtttcaa
     4441 gcttgcctag ggtgacagta aaaaatcaat ttcctttcat atcatatttt tagtagatag
     4501 gatgtttgtt ctgtctattt tttgccaaaa aaagtgcagt cgaagtgttt atttggagtt
     4561 ttatatatat tttcgataaa ataggtgtag aaattaggaa agttgaagaa aagaaatgaa
     4621 gaaggtttta aaatattttt tagtatttgt ttttctattt ttgatgaata ttttcatctt
     4681 taagatacta gcaaccctgg gatttcagct gataatgagt gaaaagagtt atattgttct
     4741 accgctgttt tcgcttatcg ttttatatat gattgacaaa agaattagga agaaaaagaa
     4801 atctttgtaa tcaacttaag gagtattact atggatgagt tgaaacgtga aattggttat
     4861 aaaatcaaaa ctattaggcg atcttgtgga aaaactcaga tagatatttg tggtgatgaa
     4921 tcagagttga cgattcgtca gctagcacgt attgaaaatg ggcaagcttt agcaacactt
     4981 cctaaattat tattgattgc ggataaactt ggagtatcat tacagaatat tgtggatgtt
     5041 aaggttatag agattccaaa aggattccta aaactcaaag atgagctgat tcattctcaa
     5101 acctacgctg ataagggaag aatcgaacga aaagaagcta tacttgagga aatatatgaa
     5161 aactattatg agaatttgcc tgaggaagag cagttaattg tggatgtgac acaagctcgt
     5221 tttgatattt atggtagttc agatgtgacc tacggtttag ggttagtgga agaatatttc
     5281 cagcagttat taaaaaagaa atatttttct gtaaatgatt tgttgattat tgaattgtat
     5341 ttcttttgtt gtgctatggg attagaagat aaagaacatt ttgaggagtt agctcaaaaa
     5401 gtattgctat gttcagaata tgaagataag gctagcctag ttcaaatgga aaaagttctt
     5461 ctgagcctat ttatccaaat tcagacagaa gatagtctga tatatattca aacatttgag
     5521 aaaattattg ctaaaacaag acatgttttt taccgacctc atctattttt gctaaaggca
     5581 aaatatgctt tatttgtaga caagaatatt ttagaggcag aaagtttcta tgaaaaggcg
     5641 atttctctag cagaattgct agacgatcag gtattagttc agagaatttt agcagaaaaa
     5701 cagatagatt tcccaacaac ctgacttcta agtcatgttg tttttttcat gtttttgcta
     5761 tactaaacct ataaagaaaa cgttctcaaa aagaaaggag gtttattatg ggtggaacgt
     5821 tatttgtcct tttaagtata ggaatttggt tctatctata atatcgggta gagattaatg
     5881 gaacaaggta ttcttatatt ggattaaagg aatgttttaa taggtttcct acattagtat
     5941 agaggatgaa actcaatttt caatgatata gaagagttat ttggagattg tgagggttga
     6001 gtatgtttat ttatgatgta ggaagtgtaa actaaaaagg aggtagtaat cgtataaaag
     6061 ttaaatagac attatctttt attgagtctt agtgatataa aagtaatttg ataatctagg
     6121 aaaatgtagt agtaatttat ttattataga tatgttaata aaagtagtat aaaatataga
     6181 cgaacatttg aagagagtta ggaatacaac atgtgcgaat taactctcaa taaaacatac
     6241 ataatataca aaaggagtac actaaaatga aatctaaaag aatggaattt cataataaat
     6301 ttcttattgt ttcagcaatg ttagcagtca ttagttggtt aagcttaggt gttgtttctt
     6361 ttcctatgtt ggctgggaca ttaggaattt cgacaaaagc tgctgctact gtagtcaatt
     6421 tgattagtgc ttatagtaca gttacagcag taatttcaat tgtaggtgca atcacaggag
     6481 taggttctat tggttcgggt attgcagcaa cagttcttta tatattgaaa aagaaaggtg
     6541 ctgctaaagc agctctatgg tagaactaga tgaaaatact ttctaaaaaa gaatgtgaaa
     6601 gtattttagg ttatcttaat tttattggga taaccctttt gttttttgtt atcataagtt
     6661 tgtcaatcta ttttaaaagc tatcttcctt ttcaagggaa attattttta ctttttttgg
     6721 tagtagatta cgctactttg aatcgttata atatgaaact gcctatccaa agtaaaaaaa
     6781 taaatacttt ctatataagg aaaaactata tttttctcta tcttcttgcc attgtcaaga
     6841 aatattattc tttccaaatt ttacaatcat tcatttattt atttattttg tattttctag
     6901 atattattgg atatttttat ttatccatta ctctttgttt gatagctatt caaattattt
     6961 ctttaattct acctagtttg ttttcaatta taagtaaatt gttcttattt ttatctatag
     7021 gactattgtc tatagaacaa ggacaagttg taatttatgt catactactc aattatttta
     7081 ttttagtcat ggggatatta gataatcatg cgagtaattt ctattttaaa agcagtcgaa
     7141 tgagtcaaaa aagatttcgt agcagtctat ttatattgct tcgtttttgt tggttaaata
     7201 aagggttaac tttttctttt attttgatta gtattcttct ttcctatcta ttttggtata
     7261 tgatgacgat gttatcaatt gatgacacaa aaataccaat attatttctt tatacctcaa
     7321 tatatattac attaatggag gcaataatag ggaatcataa atcctcaatt ggggtagatc
     7381 tagctttact tcaattatct gctcttaatc attctaaaat gaatttcttt tttaagaatg
     7441 cacaactaat gatgttgacg catttaatct ctttcttaca attttcattg ttgttatgtt
     7501 tgattccggt gacaagttat agtaatgata taaaaagtat tttgttgaat ttgttattga
     7561 ttccattcaa ttattttata gcctatgtct attataagaa agctctattt ttaattaaag
     7621 gtacagttag tttattgaga tggagttttc tggttttata ttgttttctg ataatatttg
     7681 taattttagt agggggcatt agatgagaaa aagtggtttt ctgatttact atgtgttatt
     7741 ttgtatagtc tgttttttac taggtttact tttaagcttt atattaaaaa atgagacttt
     7801 tgctactata cctccgaaac tggaattaca atttacattg acagttttac aggcaaattc
     7861 tacaaatttt ttgctatatc tattctgttt tccgatttcg cccttattgc aactttttga
     7921 tttgctatct ttaggaatac aattgggtat atctggtcag atgattggaa tagtagctac
     7981 aataaaagga atattacctc atgctcttat tgaaataccg aattttattt ggtatcaagg
     8041 tatgagtcag tatcttttat accgattatt gaaggatagg ggaattaaaa atatacttat
     8101 ttatataaaa agtaatttaa aatggtatat catttcttat cttttattaa ttttagcagc
     8161 gttgatagag ggaattaaat tatgaaaatt gaaaatgaat ctaaaagtta tgataaatgt
     8221 atattgaaaa atatatcact agagattgat aagggaattt acagagttga aggagagaat
     8281 ggttcaggaa agagcaccct tctacaactt ttagctgggc tagagacttt tgatagtggt
     8341 ttaaagaatt gtgtctccaa agatgtacta taccttgata ccaatcagct tggggttgtt
     8401 ccatttacta tagaagaaaa tttgcagttg ttgtgtgatt cttttcaaat ccatctatca
     8461 tttgaggata aagaacaaat taatactttt tttgataata aaatcggaga taactatatg
     8521 acagcatcta ctggaacaaa attcaaatta ggcttatcct taatttttgc taaaaattgg
     8581 gattatattt ttattgatga gactttatca acagtggatg caagaagtat tgatatgatt
     8641 gctaaacgct taatttccat gaaagaaagc tctactatta tatatgtatc tcataattta
     8701 ttgaatcaag aattgattag caaatctcaa aggattttaa tagaggaagg acgggtttat
     8761 gaaatttcaa acaaataata gtttatacaa attaatgaat ctgattattt atctttttct
     8821 tttatatttg tttattgatt tactgatgaa gtcgggaatt ttagatgaac aaattgataa
     8881 attatctgaa ctatctaatc tttttacaat taaaatagaa acaatattga cagtgatttc
     8941 tgttgttttc acatttatag caactcttat tgaatatgga ttttctctct ttctgattac
     9001 attatttttt gataagaata agaggaactt tggagatatt cttttatcta aaaatataac
     9061 cttaagtttt agcattttac tttgttattt atttaatcca tcggatataa agtttgccta
     9121 tttcagcgta ttgacagtat tactaattgg gataacaaat tatgcgagat ttaaaaattt
     9181 aagattgaca gtagtgtttt ctgtaccatt tttatttaat gctataatgt ctattataaa
     9241 tagtttttag aaatactaaa atttttttct ttacttaata atgatatgaa atcatttcgg
     9301 ttttgttaac ttgtaattct tatattttct aggtagaacg tttgttctgc ctattttttt
     9361 atccaaaaag tgcagttggg agggagatag gctcatttgg gaaggaagtc cagtttttgt
     9421 ttagtgattg gggtaagata gttgttatca gatgagttta tactcttcga aaatcaaatt
     9481 caaaccacgt caacgtcgcc ttgccgtata tatgtgactg acttcgtcag tcctatctac
     9541 aacctcaaaa cagtgttttg agcagcctgc ggctagtttc ctagtttgct ctttgatttt
     9601 cattgagtat tagggaaaag gagatgaata tgaaatttgg gaaacgtcac tatcgtccgc
     9661 aagtggatca gatggactgc ggtgtagctt cattagccat ggtttttggc tactatggta
     9721 gttattattt tttggctcac ttgcgagaat tggctaagac gaccatggat gggacgacgg
     9781 ctttgggctt ggtcaaggtg gcagaggaga ttggctttga gacacgagct atcaaggcgg
     9841 atatgacgct ttttgatttg cccgatttga cttttccttt tgttgcccat gtgcttaagg
     9901 aagggaaatt gctccactac tatgtggtga ctgggcagga taaggacagc attcatattg
     9961 ccgatccaga tcctggggtg aaattgacca aactgccacg tgagcgtttt gaggaagaat
    10021 ggacaggagt gactctgttt atggcaccta gtccagacta caagcctcat aaggatcaaa
    10081 agaatggtct gctctctttt atccctatat tagtgaagca gcgtggcttg attgccaata
    10141 tcgttttggc aacactcttg gtaaccttga ttaacattgt gggttcttat tatctgcagt
    10201 ctatcattga tacctatgtg ccagatcaga tgcgttcgac gttggggatt atttctattg
    10261 ggctagtcat cgtctacatc ctccagcaaa tcttgtctta cgctcaggag tatctcttgc
    10321 ttgttttggg gcaacgcttg tcgattgacg tgattttgtc ctatatcaag catgtttttc
    10381 acctccctat gtccttcttt gcgacacgca ggacagggga gatcgtgtct cgttttacag
    10441 atgctaacag tatcatcgat gcgctggctt cgaccatcct ttcgattttc ctagatgtgt
    10501 caacggttgt cattatttcc cttgttttat tttcacaaaa taccaatctc tttttcatga
    10561 ctttattggc gcttcctatc tacacagtga ttatctttgc ctttatgaag ccatttgaaa
    10621 agatgaatcg ggacaccatg gaagccaatg cggttctgtc ttcttctatc attgaggaca
    10681 tcaatggtat tgagactatc aagtccttga ccagtgaaag tcagcgttac caaaaaattg
    10741 acaaggaatt tgtggattat ctgaagaaat cctttaccta tagtcgagca gagagtcagc
    10801 aaaaggctct gaaaaaggtt gcccatctct tgcttaatgt cggcattctc tggatggggg
    10861 ctgttctggt catggatggc aagatgagtt tggggcagtt gattacctat aataccttgc
    10921 tggtttactt taccaatcct ttggaaaata tcatcaatct gcaaaccaag cttcagacag
    10981 cgcaggttgc caataaccgt ctaaatgaag tgtatctagt agcttctgag tttgaggaga
    11041 agaaaacagt tgaggatttg agcttgatga agggagagat gactttcaag caggttcatt
    11101 acaagtatgg ctatggtcga gacgtcttgt cggatatcaa tttaaccgtt ccccaagggt
    11161 ctaaggtggc ttttgtgggg atttcagggt caggtaagac gactttggcc aagatgatgg
    11221 ttaattttta cgacccaagt caaggggaga ttagtctggg tggtgtcaat ctcaatcaga
    11281 ttgataaaaa agccctgcgc cagtacatca actatctgcc tcaacagccc tatgtcttta
    11341 acggaacgat tttggagaat cttcttttgg gagccaagga ggggacgaca caggaagata
    11401 tcttacgggc ggtcgaattg gcagagattc gagaggatat cgagcgcatg ccactgaatt
    11461 atcagacaga attgacttcg gatggggcag ggatttcagg tggtcaacgt cagagaatcg
    11521 ctttggcgcg tgctctcttg acagatgcgc cggtcttgat tttggatgag gcgactagca
    11581 gtttggatat tttgacagag aagcggattg tcgataatct catagctttg gacaagacct
    11641 tgattttcat tgctcaccgc ttgactattg ctgagcggac agagaaggta gttgtcttgg
    11701 atcagggcaa gattgtcgaa gaaggaaagc atgctgattt gcttgcacag ggtggctttt
    11761 acgcccattt ggtcaatagc tagaaagagg agaggatgaa accagaattt ttagaaagtg
    11821 cggagtttta taatcgtcgt taccataatt tttccagtag tgtgattgta cccatggccc
    11881 ttctgctcgt gtttttactt ggctttgcaa ctgttgcaga aaaggagatg agtttgtcca
    11941 ctagagctac tgtcgaacct agtcgtatcc ttgcaaatat ccagtcaact agcaacaatc
    12001 gtattcttgt caatcatttg gaagaaaata agctggttaa gaagggggat cttttggttc
    12061 aataccaaga aggggcagag ggtgtccaag cggagtccta tgccagtcag ttggacatgc
    12121 taaaggatca aaaaaagcaa ttggagtatc tgcaaaagag cctgcaagaa ggggagaacc
    12181 actttccaga ggaggataag tttggctacc aagccacctt tcgcgactac atcagtcaag
    12241 taggcagtct tagggctagt acatcgcaac aaaatgagac catcgcgtcc cagaatgcag
    12301 cagctagcca aacccaagcc gaaatcggca acctcatcag tcaaacagag gctaaaattc
    12361 gcgattacca gacagttaag tcagctattg aaacaggtgc ttccttggcc ggtcagaatc
    12421 tagcctactc tctttaccag tcctacaagt ctcagggcga ggaaaatccc caaactaagg
    12481 ttcaggcagt tgcacaggtt gaagcacaga tttctcagtt agaatctagt cttgctactt
    12541 accgtgtcca gtatgcaggt tcaggtaccc agcaagccta tgcgtcaggg ttaagcagtc
    12601 aattggaatc ccttaaatcc caacacttgg caaaggttgg tcaggaattg acccttctag
    12661 cccagaaaat cttggaggca gagtcaggta agaaggtaca gggaaatctt ttagacaagg
    12721 ggaaaattac ggcaagtgag gatggggtgc ttcatcttaa tcctgagacc agtgattcta
    12781 gcatggttgc agaaggtgcc ctactagccc aactttatcc atctttggaa agagaaggga
    12841 aagccaaact cacagcctat ctaagttcaa aagatgtagc aagaatcaag gtcggtgatt
    12901 ctgttcgcta tactacgact catgatgccg ggaatcaact ttttctagat tctactatta
    12961 caagtattga tgcgacagct actaagactg agaaagggaa tttctttaaa atcgaggcgg
    13021 agattaatct aacttcggag caggctgaaa aacttaggta cggggtggaa ggccgtctac
    13081 agatgattac gggcaagaaa agttatctac gttattattt ggatcaattt ttgaacaaag
    13141 agtaatgttc gtgtttttag agttaaataa tttttaaact gtgagaaaga ttcttcttgc
    13201 agttttttct ttacaatttt tgaaaaacat ctgctattta ttcggttaaa ttcttgtgtt
    13261 ttttggtttt ttgtggtaaa atgtgctcaa gtaatacgaa aggcgaactt taaaatgtca
    13321 aaacaattga tctattcggg aaaagctaaa gatatctata caactgagga tgaaaatctt
    13381 attatttcaa cttacaagga ccaggcgact gctttcaacg gtgtcaagaa ggagcagatt
    13441 gcaggtaagg gagtcttgaa taatcagatc tcatctttta tttttgagaa attaaatgcg
    13501 gctggtgtgg cgactcactt tgtggagaaa ctttcagaca cggaacaact caataaaaag
    13561 gttaagatta ttcctttgga agtcgtgctc cgcaactata ctgctggttc cttttcaaaa
    13621 cgttttggtg tggatgaggg aatcgccttg gagactccga ttgtcgaatt ttactacaaa
    13681 aatgatgatt tggatgatcc atttatcaat gatgagcatg tgaaattcct acagattgcg
    13741 gatgaccagc agattgccta cttgaaggaa gaaacgcgtc gtatcaatga actattgaaa
    13801 gtctggtttg ctgagattgg gcttaaattg attgacttta agctagagtt cggttttgac
    13861 aaggatggca agattatctt ggcagacgaa ttttcaccag ataactgccg cttgtgggat
    13921 gctgatggca accacatgga taaggatgtt ttccgtagag gattgggaga actaaccgac
    13981 gtttatgaga ttgtttggga aaagttgcag gaattgaaat aa
//
