LOCUS       NZ_CP029491.1          10739 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  NZ_CP029491.1 Streptococcus sobrinus strain 10919 chromosome,
            complete genome.
ACCESSION   NZ_CP029491
VERSION     NZ_CP029491.1
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 6.1.1
            Run date     :: 2024-03-14 12:51:12
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 1837916
            Orig. end    :: 1848655
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     CDS             complement(1..177)
                     /locus_tag="ctg1_1701"
                     /transl_table=11
                     /translation="MNTVAFEQFTTAEQEELTEAAGGFGPFVPDPPIPYPNPILSGAIG
                     ALTGAVGYIGFGG"
     protocluster    1..10739
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[1842746:1845053](-)"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193)"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(4831..7137)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193)"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
     cand_cluster    1..10739
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193)"
                     /kind="single"
                     /product="RiPP-like"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..10739
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="RiPP-like"
                     /region_number="5"
                     /rules="(strepbact or Antimicrobial14 or Bacteriocin_IId or
                     BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or
                     Lactococcin or Antimicrobial17 or Lactococcin_972 or
                     Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or
                     TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or
                     TIGR03975 or DUF692 or TIGR01193)"
                     /tool="antismash"
     CDS             complement(637..813)
                     /locus_tag="ctg1_1702"
                     /transl_table=11
                     /translation="MKENTAIMNFANATDEELQEINGGILPILATAAAVVGICAGAYAL
                     SYGAGEAWYNMTH"
     aSDomain        complement(682..774)
                     /aSDomain="TIGR03949"
                     /aSTool="tigrfam"
                     /description="bact_IIb_cerein: class IIb bacteriocin,
                     lactobin A/cerein 7B family"
                     /detection="hmmscan"
                     /domain_id="TIGRFam_ctg1_1702_0029"
                     /evalue="2.00E-09"
                     /identifier="TIGR03949"
                     /label="ctg1_1702"
                     /locus_tag="ctg1_1702"
                     /protein_end="44"
                     /protein_start="13"
                     /score="35.1"
                     /tool="antismash"
                     /translation="TDEELQEINGGILPILATAAAVVGICAGAYA"
     CDS             complement(833..1018)
                     /locus_tag="ctg1_1703"
                     /transl_table=11
                     /translation="MNTIAFEKFETVDANSLMAIEGGWFWDNWKGGEWALAGAWALGPG
                     TGIIATGFYNGYNSHG"
     CDS             complement(1101..1274)
                     /locus_tag="ctg1_1704"
                     /transl_table=11
                     /translation="MKENTAIMNFDNVTDEELQKINGGIIGIDDVAAIVGICAGAYALS
                     YGVGQAWYTMTH"
     aSDomain        complement(1128..1247)
                     /aSDomain="TIGR03949"
                     /aSTool="tigrfam"
                     /description="bact_IIb_cerein: class IIb bacteriocin,
                     lactobin A/cerein 7B family"
                     /detection="hmmscan"
                     /domain_id="TIGRFam_ctg1_1704_0030"
                     /evalue="7.40E-07"
                     /identifier="TIGR03949"
                     /label="ctg1_1704"
                     /locus_tag="ctg1_1704"
                     /protein_end="49"
                     /protein_start="9"
                     /score="26.8"
                     /tool="antismash"
                     /translation="FDNVTDEELQKINGGIIGIDDVAAIVGICAGAYALSYGVG"
     aSDomain        complement(1203..1247)
                     /aSDomain="TIGR01847"
                     /aSTool="tigrfam"
                     /description="bacteriocin_sig: bacteriocin-type signal
                     sequence"
                     /detection="hmmscan"
                     /domain_id="TIGRFam_ctg1_1704_0031"
                     /evalue="3.30E-03"
                     /identifier="TIGR01847"
                     /label="ctg1_1704"
                     /locus_tag="ctg1_1704"
                     /protein_end="24"
                     /protein_start="9"
                     /score="16.0"
                     /tool="antismash"
                     /translation="FDNVTDEELQKINGG"
     CDS             complement(1296..1481)
                     /locus_tag="ctg1_1705"
                     /transl_table=11
                     /translation="MNTIAFEKFETVDANSLMAVEGGWFWDNWKGGEWALAGAWALGPG
                     TGIIATGFYNGYNSHG"
     CDS             complement(1775..1966)
                     /locus_tag="ctg1_1706"
                     /transl_table=11
                     /translation="MDTRISENFEEMSSEELTAVSGGFFPEPPIVPVIPYYGFGTLIGG
                     AVGSLYGSFAGSGSASKF"
     aSDomain        complement(1898..1942)
                     /aSDomain="TIGR01847"
                     /aSTool="tigrfam"
                     /description="bacteriocin_sig: bacteriocin-type signal
                     sequence"
                     /detection="hmmscan"
                     /domain_id="TIGRFam_ctg1_1706_0032"
                     /evalue="5.40E-03"
                     /identifier="TIGR01847"
                     /label="ctg1_1706"
                     /locus_tag="ctg1_1706"
                     /protein_end="23"
                     /protein_start="8"
                     /score="15.3"
                     /tool="antismash"
                     /translation="FEEMSSEELTAVSGG"
     CDS             complement(2268..2492)
                     /locus_tag="ctg1_1707"
                     /transl_table=11
                     /translation="MNTVAFEEFATVENDNLAAVAGGERTIFMECANGYSYRDENGHWG
                     YQVTKSPLEAATNTIVNSWASGIASFAAY"
     CDS             complement(2713..3411)
                     /locus_tag="ctg1_1708"
                     /transl_table=11
                     /translation="MKASPRVHSVDSFVYAYKEEHPSETVPSTKTLYNYSHQGLLAIKA
                     IDFPKAVRLRKKTKKRSSTQKHLGVSIEERPETINDRSVFGHWEIDSVLGTQKAGEPSI
                     LTLVERKTRYAITAYLAGKKAEDVNEAVAELIQQYPIKSITADNGSEFASLNELEGVQV
                     YYAHAYSSYERGTNENFNGLLREFVPKGKSLKTLTAEDLAKATLAINQRPRRLLNYQTA
                     KTLFGLTQTA"
     CDS             complement(3429..3731)
                     /locus_tag="ctg1_1709"
                     /transl_table=11
                     /translation="MSTTNCTTKQPYCHLSEVERGKIETFLSEGVKPAEIARRLGRSRS
                     TISREIKRGTTKQVKQVNGKKIYFDYYFADLAQRRYVEGRQGIDYLKLEKDLSTF"
     PFAM_domain     complement(3570..3692)
                     /aSDomain="HTH_38"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF13936.8"
                     /description="Helix-turn-helix domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_1709_0098"
                     /evalue="1.20E-14"
                     /label="ctg1_1709"
                     /locus_tag="ctg1_1709"
                     /protein_end="54"
                     /protein_start="13"
                     /score="53.8"
                     /tool="antismash"
                     /translation="HLSEVERGKIETFLSEGVKPAEIARRLGRSRSTISREIKRG"
     CDS             complement(3893..4816)
                     /locus_tag="ctg1_1710"
                     /transl_table=11
                     /translation="MNPKLLESAEFYRRRYHNFATVLIVPLVILIIFIGVFLCFAKKEI
                     TVISQGEVAPTKVLAVIQSVSDTSIAQNKLDDNTKVDKGDLLVQYTENAEPEQKDAQKN
                     TIKDRNDRLDKEIEKEEKKTKKKYKKLSKKERKKREKKDQKKKEKKKKDRDSEDKKETD
                     HVSLFAPESGVIHTNSKYDGLNILPKWSEIAQIYPDIQKTKTVLITYYVSSDDVVSMKK
                     GQTTRLSLEKKGNDKLTVQGKINSVAASATTTKKGNLFKVTAKVKLSKKDSKLVKYGMT
                     GKTVTVIDKKTYFDYFKDKLLHKVED"
     PFAM_domain     complement(3980..4318)
                     /aSDomain="HlyD_3"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF13437.8"
                     /description="HlyD family secretion protein"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_1710_0099"
                     /evalue="1.30E-14"
                     /label="ctg1_1710"
                     /locus_tag="ctg1_1710"
                     /protein_end="279"
                     /protein_start="166"
                     /score="54.8"
                     /tool="antismash"
                     /translation="LFAPESGVIHTNSKYDGLNILPKWSEIAQIYPDIQKTKTVLITYY
                     VSSDDVVSMKKGQTTRLSLEKKGNDKLTVQGKINSVAASATTTKKGNLFKVTAKVKLSK
                     KDSKLVKYG"
     CDS             complement(4831..7137)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: TIGR01193"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_C39"
                     /gene_functions="resistance (resist) ABC_efflux (Score:
                     258.4; E-value: 8.4e-79)"
                     /gene_functions="transport (smcogs) SMCOG1288:ABC
                     transporter related protein (Score: 332.2; E-value:
                     1e-100)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg1_1711"
                     /sec_met_domain="TIGR01193 (E-value: 0.0, bitscore: 1106.5,
                     seeds: 5, tool: rule-based-clusters)"
                     /sec_met_domain="Peptidase_C39 (E-value: 3.2e-40, bitscore:
                     133.9, seeds: 36, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKQITYIILIVALVIAVNIILEAFRRYFRSKRGKSSPQSSQAVAG
                     SSSSVGLFWRRRYKFIPQVDTRDCGPAALASVAKHYGSDYSLARLRELSKTDKQGTTAL
                     GLVEAAKAIGFETRSIKADMTLFDYTDLTYPFIVHVVKNKRLQHYYVVYANAGDSLIIG
                     DPDPTVKVTRMSKRDFQEEWTGLAIFLAPTPNYKPKKDEKNGLMSFFPIILRQKALLTY
                     IVLASLMVTLIDIVGSYYLQGMLDEYIPDQLISTLGIITIGLIITYIIQQMMSFAKEYL
                     LNVLSLRLVIDVILSYIKHIFTLPMSFFATRRTGEITSRFSDANQIINAVASTIFSIFL
                     DVTMLLIVGGVLLVQNSHLFLLTLLSIPIYAIIITAFLKPFEKMNHEVMEANAMVSSSI
                     IEDINGMETIKSLTSESSRYQNIDGEFVDYLEKNFKLQKMNALQTSLKTGAKLILNVVI
                     LWYGARLVMDGKISVGQLITFNALLSYFQNPIENIISLQTKLQSARVANTRLNEVYLVE
                     SEFENDGELSEDSFLDGDISFEKLSYKYGYGRDTLSDINLTIAKGSKVSLVGPSGSGKT
                     TLAKMMVNFYDPNRGIARINGYDLKVIDKTALRQHISYLPQQAYVFSGTIMDNLTLGAK
                     EGTTQEDIIRACEIAEIRSDIEQMPLGYQTELSDGAGVSGGQKQRIALARALLTQAPVL
                     ILDEATSSLDVLTEKKIVDNLMTMTDKTVIFVAHRLSIAQRTDRIIVMDQGKIVEEGSH
                     KELLANKGFYYTLFN"
     aSDomain        complement(4834..6951)
                     /aSDomain="TIGR01193"
                     /aSTool="tigrfam"
                     /description="bacteriocin_ABC: ABC-type bacteriocin
                     transporter"
                     /detection="hmmscan"
                     /domain_id="TIGRFam_ctg1_1711_0033"
                     /evalue="0.00E+00"
                     /identifier="TIGR01193"
                     /label="ctg1_1711"
                     /locus_tag="ctg1_1711"
                     /protein_end="768"
                     /protein_start="62"
                     /score="1106.5"
                     /tool="antismash"
                     /translation="QVDTRDCGPAALASVAKHYGSDYSLARLRELSKTDKQGTTALGLV
                     EAAKAIGFETRSIKADMTLFDYTDLTYPFIVHVVKNKRLQHYYVVYANAGDSLIIGDPD
                     PTVKVTRMSKRDFQEEWTGLAIFLAPTPNYKPKKDEKNGLMSFFPIILRQKALLTYIVL
                     ASLMVTLIDIVGSYYLQGMLDEYIPDQLISTLGIITIGLIITYIIQQMMSFAKEYLLNV
                     LSLRLVIDVILSYIKHIFTLPMSFFATRRTGEITSRFSDANQIINAVASTIFSIFLDVT
                     MLLIVGGVLLVQNSHLFLLTLLSIPIYAIIITAFLKPFEKMNHEVMEANAMVSSSIIED
                     INGMETIKSLTSESSRYQNIDGEFVDYLEKNFKLQKMNALQTSLKTGAKLILNVVILWY
                     GARLVMDGKISVGQLITFNALLSYFQNPIENIISLQTKLQSARVANTRLNEVYLVESEF
                     ENDGELSEDSFLDGDISFEKLSYKYGYGRDTLSDINLTIAKGSKVSLVGPSGSGKTTLA
                     KMMVNFYDPNRGIARINGYDLKVIDKTALRQHISYLPQQAYVFSGTIMDNLTLGAKEGT
                     TQEDIIRACEIAEIRSDIEQMPLGYQTELSDGAGVSGGQKQRIALARALLTQAPVLILD
                     EATSSLDVLTEKKIVDNLMTMTDKTVIFVAHRLSIAQRTDRIIVMDQGKIVEEGSHKEL
                     LANKGFYYTLFN"
     PFAM_domain     complement(5035..5484)
                     /aSDomain="ABC_tran"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00005.29"
                     /description="ABC transporter"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_1711_0102"
                     /evalue="5.10E-31"
                     /label="ctg1_1711"
                     /locus_tag="ctg1_1711"
                     /protein_end="701"
                     /protein_start="551"
                     /score="108.1"
                     /tool="antismash"
                     /translation="LSDINLTIAKGSKVSLVGPSGSGKTTLAKMMVNFYDPNRGIARIN
                     GYDLKVIDKTALRQHISYLPQQAYVFSGTIMDNLTLGAKEGTTQEDIIRACEIAEIRSD
                     IEQMPLGYQTELSDGAGVSGGQKQRIALARALLTQAPVLILDEATS"
     PFAM_domain     complement(5671..6480)
                     /aSDomain="ABC_membrane"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00664.25"
                     /description="ABC transporter transmembrane region"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_1711_0101"
                     /evalue="3.70E-56"
                     /label="ctg1_1711"
                     /locus_tag="ctg1_1711"
                     /protein_end="489"
                     /protein_start="219"
                     /score="190.9"
                     /tool="antismash"
                     /translation="LTYIVLASLMVTLIDIVGSYYLQGMLDEYIPDQLISTLGIITIGL
                     IITYIIQQMMSFAKEYLLNVLSLRLVIDVILSYIKHIFTLPMSFFATRRTGEITSRFSD
                     ANQIINAVASTIFSIFLDVTMLLIVGGVLLVQNSHLFLLTLLSIPIYAIIITAFLKPFE
                     KMNHEVMEANAMVSSSIIEDINGMETIKSLTSESSRYQNIDGEFVDYLEKNFKLQKMNA
                     LQTSLKTGAKLILNVVILWYGARLVMDGKISVGQLITFNALLSYFQNP"
     PFAM_domain     complement(6556..6969)
                     /aSDomain="Peptidase_C39"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF03412.17"
                     /description="Peptidase C39 family"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_1711_0100"
                     /evalue="3.10E-39"
                     /label="ctg1_1711"
                     /locus_tag="ctg1_1711"
                     /protein_end="194"
                     /protein_start="56"
                     /score="133.9"
                     /tool="antismash"
                     /translation="RYKFIPQVDTRDCGPAALASVAKHYGSDYSLARLRELSKTDKQGT
                     TALGLVEAAKAIGFETRSIKADMTLFDYTDLTYPFIVHVVKNKRLQHYYVVYANAGDSL
                     IIGDPDPTVKVTRMSKRDFQEEWTGLAIFLAPTP"
     CDS             complement(7610..7783)
                     /locus_tag="ctg1_1712"
                     /transl_table=11
                     /translation="VSPVKLIEKIERGQINPESKKSVALLVLISGVGEEIITFGAIADA
                     YFGYKAEGYLIN"
     CDS             8879..10039
                     /locus_tag="ctg1_1713"
                     /transl_table=11
                     /translation="MKKTLNLQDFGVQMWDDKTIQSFRRTLLAWYDQEKRDLPWRRTKD
                     PYHIWISEIMLQQTQVQTVIPYYLRFLDWFPSIKDLAQAPEEQLLKAWEGLGYYSRVRN
                     LQKGAQQIMNDFAGIFPKTYQEILSLKGIGPYTAGAIASIAFGLPEPAVDGNVMRVMAR
                     LFEVDYDIGNPSNRKIFQAIMEELIDPERPGDFNQALMDLGTDIESAKNPRPDESPIRA
                     FNAAYLHGTYDKYPIKLPKKKPKPMQLQAFIIRNQEGQFLLEKNQKAGLLAGFWSFPLM
                     ETQLLAKQLNLFEEDKDDEVLEKVSLKNVFEEDYGLKPVWTKGNFPLVKHTFSHQKWQV
                     SLLEGQIDQTDLKGDKDLCWVAPEDFVNYPMATPQKKMIEAYQQKD"
     aSDomain        8945..9739
                     /aSDomain="TIGR01084"
                     /aSTool="tigrfam"
                     /description="mutY: A/G-specific adenine glycosylase"
                     /detection="hmmscan"
                     /domain_id="TIGRFam_ctg1_1713_0034"
                     /evalue="2.00E-96"
                     /identifier="TIGR01084"
                     /label="ctg1_1713"
                     /locus_tag="ctg1_1713"
                     /protein_end="287"
                     /protein_start="22"
                     /score="320.7"
                     /tool="antismash"
                     /translation="FRRTLLAWYDQEKRDLPWRRTKDPYHIWISEIMLQQTQVQTVIPY
                     YLRFLDWFPSIKDLAQAPEEQLLKAWEGLGYYSRVRNLQKGAQQIMNDFAGIFPKTYQE
                     ILSLKGIGPYTAGAIASIAFGLPEPAVDGNVMRVMARLFEVDYDIGNPSNRKIFQAIME
                     ELIDPERPGDFNQALMDLGTDIESAKNPRPDESPIRAFNAAYLHGTYDKYPIKLPKKKP
                     KPMQLQAFIIRNQEGQFLLEKNQKAGLLAGFWSFPLMETQLLA"
     PFAM_domain     9029..9427
                     /aSDomain="HhH-GPD"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00730.27"
                     /description="HhH-GPD superfamily base excision DNA repair
                     protein"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_1713_0103"
                     /evalue="2.90E-18"
                     /label="ctg1_1713"
                     /locus_tag="ctg1_1713"
                     /protein_end="183"
                     /protein_start="50"
                     /score="66.3"
                     /tool="antismash"
                     /translation="ISEIMLQQTQVQTVIPYYLRFLDWFPSIKDLAQAPEEQLLKAWEG
                     LGYYSRVRNLQKGAQQIMNDFAGIFPKTYQEILSLKGIGPYTAGAIASIAFGLPEPAVD
                     GNVMRVMARLFEVDYDIGNPSNRKIFQAI"
     PFAM_domain     9629..10021
                     /aSDomain="NUDIX_4"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF14815.8"
                     /description="NUDIX domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_1713_0104"
                     /evalue="1.10E-18"
                     /label="ctg1_1713"
                     /locus_tag="ctg1_1713"
                     /protein_end="381"
                     /protein_start="250"
                     /score="67.2"
                     /tool="antismash"
                     /translation="AFIIRNQEGQFLLEKNQKAGLLAGFWSFPLMETQLLAKQLNLFEE
                     DKDDEVLEKVSLKNVFEEDYGLKPVWTKGNFPLVKHTFSHQKWQVSLLEGQIDQTDLKG
                     DKDLCWVAPEDFVNYPMATPQKKMIEA"
     CDS             10311..10739
                     /locus_tag="ctg1_1714"
                     /transl_table=11
                     /translation="MKMTVYFDGGFWFALLEYQDKKLGYQAFRYAFGKEPKDKEVLNFV
                     HRRLSHWMRRQEELGLVIDEPDKSMSHKSINPKRMQREVSKQMKKPVLSSKAQQAMQAS
                     YELLKQKKKASKRQQKQEYKERQFQLKQEKRRQKKKGH"
     PFAM_domain     10317..10736
                     /aSDomain="DUF2992"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF11208.10"
                     /description="Protein of unknown function (DUF2992)"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_1714_0105"
                     /evalue="3.30E-39"
                     /label="ctg1_1714"
                     /locus_tag="ctg1_1714"
                     /protein_end="142"
                     /protein_start="2"
                     /score="134.2"
                     /tool="antismash"
                     /translation="MTVYFDGGFWFALLEYQDKKLGYQAFRYAFGKEPKDKEVLNFVHR
                     RLSHWMRRQEELGLVIDEPDKSMSHKSINPKRMQREVSKQMKKPVLSSKAQQAMQASYE
                     LLKQKKKASKRQQKQEYKERQFQLKQEKRRQKKKGH"
ORIGIN
        1 ctacccacca aacccaatat atccgacagc ccccgttaaa gctccaatag ctccactaag
       61 aataggattt ggatatggaa ttggagggtc tggaacgaaa ggtccaaagc cacctgccgc
      121 ctctgttaat tcttcttgct ctgctgttgt aaattgttca aatgctactg tattcatgtg
      181 aatcccccct tattttttac ttggtcatct actactttac ttcatgtaat ttgacctgtt
      241 tttgttactg atcaactgaa cttattttca attgataata aatattgtaa ggaataaaac
      301 acaagtaggc aagtgatctt gggcggttta accaaattaa aagacgtccg aagacgacag
      361 ctaaattttc taaactattt ctgttcggag atgttgttac tcttatgaaa tgggctggtt
      421 ttacgcaatc tatcaacgaa aaatttgctg attgcttttt gcgtagagga tgaaccaata
      481 cctgcttaaa taatctaaaa gtccagactc aagaaaataa gtagttttta aagaagcaaa
      541 aaacctgcca gaacaagtct gaacaggtct ctttgcttct atctaactag agcattatat
      601 taataaggtt caattgccct aaaattagag ttagaattag tgtgtcatat tataccatgc
      661 ttcaccggca ccataagaca gggcatacgc acctgcgcag attccaacta cagcagcagc
      721 agtagcaagt atagggagaa taccaccgtt gatttcttga agttcttcat ctgttgcgtt
      781 agcaaagttc ataattgcag tattttcttt cattgttctt atctcctata tcttatccgt
      841 gtgaattgta tccgttgtag aatcctgtgg caatgatacc tgtaccaggg ccaagtgccc
      901 atgcaccagc tagcgcccat tcgccacctt tccagttatc ccagaaccag ccaccttcaa
      961 tggccatcaa actatttgcg tcaacagttt caaatttttc aaatgcaatt gtattcatgt
     1021 gaatcccctt gttgttatta gatcactgtt cgattatttt tagagagact gcctctaaaa
     1081 aaactacttt aatatcggaa ttagtgtgtc atcgtatacc atgcctgacc gacaccataa
     1141 gacagggcat acgcacctgc gcagattcca actatggcag caacatcatc aattccaata
     1201 ataccaccat tgattttttg aagttcttcg tctgttacgt tatcaaagtt cataattgca
     1261 gtattttctt tcattgttct tatctcctat attctttatc cgtgtgaatt gtatccgttg
     1321 tagaatcctg tggcaatgat acctgtacca gggccaagtg cccatgcacc agctagcgcc
     1381 cattcgccac ctttccagtt gtcccagaac cagccacctt caacagccat taaactgttt
     1441 gcgtcgacag tttcaaattt ttcaaatgca atagtattca tatgaatatc ctccttattt
     1501 agtgcttggt cgcttactac tcctgtaatt gacctatctt cttttaccaa tcgaaattat
     1561 tttcaattga tagtaattat tatacgagat agagcgcaca tagacaagca attctgagag
     1621 acttaattaa attttaaaaa attgataacg tttactaaaa tttctgaatt attatcattt
     1681 gaaaataaat acaaaaatcc aactctagaa agaactagaa tcggatctca ccttattatt
     1741 aaatcattgt ttatattttt agagaatgct gtctctaaaa cttactggca ctgccactgc
     1801 cagcaaaact accataaagg ctgccaactg caccaccgat taaagttcca aatccataat
     1861 aaggaattac tggaacgatc ggaggttctg gaaagaaacc tcccgagact gctgtcaatt
     1921 cttctgaact catttcttca aaattttctg aaattcttgt atccatgttg aataccctcc
     1981 ttaaatttaa ctcggccttt cactcactcc gtgtaaattg acctgttttg tcactgatca
     2041 actgaattta ttttcaattg ataacaacta ttttagcgaa cttaaattct gttagcaagc
     2101 attttaaagg tttttaaaga ttcagcaata caaatgatgt ggtgccttaa ttttttcgaa
     2161 tatttttatt tgaaaataaa taaaatcaac cccagacaga gttgatttta atttacaaac
     2221 taatcagccc agtaaagcta aatccgcttt aggatagaag ccaattctta ataagctgca
     2281 aaactagcaa tacctgaagc ccaactattt acaatagtat tcgtagctgc ttccaaagga
     2341 ctcttggtaa cttgataacc ccagtggcca ttctcatctc tgtaggaata accgttagca
     2401 cattccataa atatagtgcg ttcaccacca gcgactgccg ctagattatc attttcgact
     2461 gttgcaaatt cttcaaatgc gactgtattc attagtaaat ctccttttgg ccagaattct
     2521 gccccgataa tttcttgtca gttgaagttt ttctgactga caaagactag tttagcaggc
     2581 taaaaagcct aaagcaagca attttggagt ttttaaccga gataaaaatt aatcgaaaag
     2641 ggaaagtgaa ttttctcccg aattgtcaag ttaagcgcaa cagttgttat ccgataccaa
     2701 gttgaagagg ggctaggctg tttgggttag cccaaacagg gttttcgccg tttgatagtt
     2761 gagtagtctt cttggtcttt gattgatagc taaggtcgcc ttagctaaat cctcagctgt
     2821 gagagtcttg agcgacttac ctttaggaac gaactctcta agtaagccgt tgaagttctc
     2881 atttgtccca cgttcgtatg aggagtaagc atgggcatag taaacctgaa caccttctaa
     2941 ttcattcaag gaagcgaact cagaaccatt atcagctgta atggatttga tgggatactg
     3001 ctgaataagc tcagctaccg cctcgttaac gtcctcagct tttttaccag ccaggtaagc
     3061 tgtaatagcg tagcgggttt tccgctcaac caaagtcaag atggaaggtt ctccagcttt
     3121 ctgagtccct aatacggagt caatttccca atgtccaaat acagagcggt cattgatggt
     3181 ttctggcctc tcttcaatgg agacaccaag gtgtttctgc gttgaagagc gcttcttagt
     3241 ctttttacga agccgtacag ctttagggaa atcaatggcc ttaatagcta gcaagccttg
     3301 atgactatag ttgtaaaggg ttttggtact tggaacggtt tcacttgggt gttcctcttt
     3361 ataagcataa acgaagctgt ctacactatg aactctggga gaggccttca tggcttcttc
     3421 aaaggccttt agaaagtgct cagatccttt tcgagtttga ggtagtcaat tccttgtcgc
     3481 ccttcaacgt aacgcctttg agctaggtca gcgaagtagt agtcaaagta gatcttttta
     3541 ccattgacct gcttgacttg ttttgtcgtc ccacgcttga tttcacgtga aatggtggag
     3601 cgacttcttc ccaaacgtct agcaatctca gctggtttca ccccttctga taggaaggtc
     3661 tcaatttttc ctcgttctac ctctgagagg tggcaatagg gttgttttgt ggtacaattt
     3721 gtggtggaca tgcttatctc tttccttata ctttgtttcg caactttagt atatcagata
     3781 agcttgtctt tttttgttgc acctcatttt acaacggagc aagtgaattt tctaaatata
     3841 tccatttgaa aataaatagc ccagctcatt cgagccgaac tatctgttga aattaatcct
     3901 ccaccttgtg aagcaattta tccttgaagt aatcgaagta ggtcttttta tcaatgacgg
     3961 tgactgtctt tccagtcatc ccatacttga ccagcttgct gtccttcttg gacagcttga
     4021 ccttggctgt gaccttgaag aggttgccct tcttggtcgt cgtggccgat gcagcgacac
     4081 tattgatttt cccttggacg gtcagtttat cattgccttt cttttcaagc gataaacggg
     4141 tcgtttggcc cttcttcatg gaaacaacat cgtcagatga gacgtagtag gtaattaaga
     4201 cggttttcgt cttttgaata tcaggataga tttgggcaat ttctgaccac ttaggaagga
     4261 tattgaggcc atcatactta ctgttagtat ggatcactcc tgactcagga gcaaagaggg
     4321 aaacgtggtc tgtttctttt ttatcctctg aatctcggtc ttttttcttt ttctccttct
     4381 tcttctggtc ttttttctcc cgtttcttcc tttccttttt ggaaagcttt ttatactttt
     4441 tctttgtttt cttctcttcc ttttctattt ccttgtctag gcggtcattg cggtccttga
     4501 ttgtattctt ttgggcatcc ttttgttctg gttccgcatt ctctgtgtac tgcaccaaga
     4561 ggtcaccctt atcaacctta gtgttgtcgt ctaatttatt ttgtgcaatc gatgtgtcac
     4621 taacagactg gataacggcc aatacctttg ttggcgccac ttcaccttga gaaatcactg
     4681 tgatttcctt tttggcaaag cagaggaaaa caccaatgaa gataatcaag ataaccaagg
     4741 gcacaataag aacagtcgca aaattatggt agcgacgacg gtaaaattcc gcactttcaa
     4801 gtaattttgg attcatgtta gatgcctccc ttagttaaac agtgtgtagt agaagccctt
     4861 attagccaag agttccttat ggctaccttc ttccacaatc tttccttggt ccatgacgat
     4921 aatccgatct gtcctttgcg cgatactcaa tcggtgggcg acaaagataa cggtcttgtc
     4981 ggtcatggtc atgaggttat cgacaatttt cttttcggtc agaacatcca aactgctggt
     5041 ggcctcatcc aaaattaaga caggggcctg agttaggagg gcacgggcca acgcaattct
     5101 ttgcttctga ccgcctgaaa ccccagcacc gtcagagagt tctgtttggt aaccaagagg
     5161 catctgctca atatccgagc ggatttctgc aatttcacaa gctcggataa tgtcttcctg
     5221 ggtagtgcct tccttagccc ctagggttag gttatccatg atggtgccag aaaagacata
     5281 ggcttgttgg ggtaaataac taatatgttg ccgcagggca gtcttatcaa tgaccttgag
     5341 atcatagccg ttgatacggg caatccctcg gttaggatca tagaaattga ccatcatctt
     5401 agctaaggtt gtcttaccag agcctgatgg tcctaccaag ctgaccttag agcctttggc
     5461 aatggtcagg ttgatgtctg aaagggtatc gcgaccataa ccatacttgt aggacagttt
     5521 ctcaaaggag atatccccat ctaggaagct atcttctgag agttcgccat cgttttcaaa
     5581 ctcggattct accaaataga cttcattaag acgggtgttg gctacacgcg ctgattgcag
     5641 tttagtttgc aagctgatga tattttcaat tggattttgg aagtaagaca agagagcatt
     5701 aaaggtaatc aattgcccaa cagaaatctt accatccata actaagcgtg ccccatacca
     5761 gaggatgact acattgagaa tgagtttcgc cccagtcttg agtgaggtct gcagggcatt
     5821 catcttttga agtttgaaat ttttctccaa ataatcaacg aattcaccat cgatattttg
     5881 gtaacgactg gattcactgg tcaaagattt gatggtttcc atcccgttaa tatcttcaat
     5941 gatagaagag gagaccatgg cattggcttc catcacctca tggttcatct tttcaaacgg
     6001 tttgaggaag gctgtaatga taatggcata aatcggaatg gacagcaggg tcaagagaaa
     6061 gaggtggctg ttttgtacca agagcacccc gccgacaatc agtaacatag tgacatctaa
     6121 gaagatggag aagatggttg acgcgacagc attaatgatc tgattggcat cagaaaaacg
     6181 agaggtaatt tccccggtcc gccgagtcgc aaagaaagac ataggcaggg taaagatgtg
     6241 cttgatataa gatagaataa catcaatcac cagccgcagg ctaaggacat taagcaagta
     6301 ttccttggca aagctcatca tctgctgaat gatataggta ataatcaagc cgatggtaat
     6361 aatacccaga gttgaaatta actggtctgg aatgtattca tccagcatgc cctggagata
     6421 gtaagaacca acaatatcaa tcagggttac catcagactg gctaaaacaa tgtaagtcaa
     6481 gagggccttc tgtctcagaa tgatggggaa gaagctcatg agaccatttt tttcgtcttt
     6541 cttgggctta tagttagggg tgggcgctag aaagatagcc agacctgtcc actcttcctg
     6601 aaaatctcgc ttagacatgc gggtgacctt gacggtagga tctgggtccc caataatcag
     6661 gctatcacca gcattggcat agacgacata atagtgctgg agacgcttgt tcttaaccac
     6721 atggacaata aaagggtatg ttaaatccgt atagtcaaac aaagtcatat cagccttgat
     6781 cgagcgggtt tcaaaaccaa tagccttggc agcttctact aaaccaagag ctgtcgttcc
     6841 ctgcttgtca gtctttgaaa gctctcgcaa tctagccaga gaatagtccg aaccatagtg
     6901 cttggctact gaagctaggg ctgctggacc acagtctctg gtatccactt gaggaataaa
     6961 cttgtagcgc ctacgccaaa atagcccaac tgaactggaa gaaccagcta ctgcttgaga
     7021 tgattgagga ctagacttcc ctctcttaga tctaaagtag cgtctaaagg cctctaaaat
     7081 aatattgact gcgataacaa gagctacaat caaaataata taagtgatct gcttcataag
     7141 attcctttcc agccaacccg tgaaaatagt tgaggacgat ttcagaaaaa tatccccgac
     7201 accaaataag gaacagggca tatctatcta tgaagtcagt ttaacaaaaa tagactcaat
     7261 tagcaatatt tttaagattt acttaataaa ataaaaacaa agacgatacc taaataagaa
     7321 ttttctgaaa atttaatata tacgaaaatc tttttccttt caaaaaattc cctgatacca
     7381 aaatgaaggt ggagattttc agctatgctt actcttattt aaaaaatgaa aaaaactcaa
     7441 gcgatattct taggtgcata ataaatcgta gatggctagc aaaattatca tcattaaaat
     7501 tgacgtgaaa gatagggggt taaatttccc atttttagag aatcttaaaa aaattgtatc
     7561 taaattatca aaaatatcta aaggataaaa tttataacat acttcatggt taattaatca
     7621 aataaccttc tgccttatag ccaaaataag catcagcaat ggctccaaag gtaataattt
     7681 cttctccaac tccagaaatc agtaccaata gtgctactga ttttttagat tctggattta
     7741 tttgtcctct ttcaattttt tctattagtt tgactggcga cacgacttag ctcttatcaa
     7801 atgtgattat taatctaatt catcttagaa acttttaact tttctagcta acctactttc
     7861 atactagtaa aaaagggcca agtagttagt cacagtattg gcaaaagttc ccgataataa
     7921 aaaagcacta aaaaatccga ttcttgcaca cttagaatcg gattctattg ttctgtttca
     7981 atttctgtca agctagcatc acgcctttct tttttctcat aaggaggtta aggtagataa
     8041 ttgtctccgt tttgattacg gcttaaattc aatcttaatg ccacctcttt caatgacaag
     8101 tagattttgc ttttttgaat atctaatttt cttttttatc atttaccttg ctgagttatc
     8161 ttctactttc agcctctaat tttaatacta gacttcatta agcagttttt tattaaattt
     8221 ttcattacat cagtttcacc ccttaagcta ttttatgcaa cagcctagga tgtctccgtt
     8281 tttatagcgt ccttgattaa agtttagcat aagcacacct tcttttctca atgtacacta
     8341 gaattttggc atgggtacca ctcctttagc tattctatgc gacagctaaa gaatctccat
     8401 ttttgtaacg acttaggtca aacatcaaca taagcgttcc tccagcactt ttgcaagatt
     8461 tacaactgac tagtaagatt aactactgtt aggactatga gctttacttt aaaaatcttc
     8521 tgcttactac tatgtctcaa actagaacta gcaatcaacc actaattggt cggttacgct
     8581 tatcattgaa ctactgtctc catttttgta ccgagattta ttcatgttaa tcattacaat
     8641 cacctcttaa cacaatatct catacgaact agcgacaata cttaccgtaa aattaatctt
     8701 tatttgccta ccatctaagg cctgtcaccg ttcttgtacc tcgaaatgtt ttgtctaatc
     8761 atgggaatac ctccttgatt aagtcttatc ttatttacat tttcattata atgtaagcgt
     8821 tttcctttgt caagctttta aatctttttt atcaaacatt tttgttataa tttttcctat
     8881 gaagaaaaca ctaaatttac aagactttgg tgtccaaatg tgggatgaca aaactatcca
     8941 gtcctttcgg cggaccctct tggcttggta tgaccaagaa aaaagagacc taccctggcg
     9001 gcggaccaag gatccctacc atatctggat ttctgaaatc atgctgcaac agacccaagt
     9061 tcaaacagtc attccttatt atctaagatt tttagactgg ttccctagta ttaaagattt
     9121 agcccaggct cctgaggaac agttgctcaa agcctgggaa ggcctaggct attactctcg
     9181 cgtcagaaat ctgcaaaagg gtgcccagca aatcatgaac gattttgctg ggatctttcc
     9241 taagacctac caagagattc tgagtttaaa aggaattggt ccttacaccg ctggggccat
     9301 tgccagtatc gcctttggcc tgcctgagcc cgctgttgat ggtaatgtca tgcgggtcat
     9361 ggcccgcctc tttgaggtag actatgacat cggcaatcct agcaatagaa aaattttcca
     9421 ggctattatg gaggaactga ttgaccctga gcgacctggt gattttaatc aggccttgat
     9481 ggacttggga acggatatcg aatccgctaa aaatcccaga cctgacgaaa gccccatccg
     9541 ggccttcaat gctgcctatt tacacgggac ctacgacaaa tatcctatta agctacccaa
     9601 gaaaaagccc aagcctatgc agcttcaggc tttcatcatc cgaaatcaag agggacagtt
     9661 tcttttggag aagaatcaaa aggctggcct cctagcaggc ttctggtcct ttcccctgat
     9721 ggagacccag ctcctagcca agcagctcaa tcttttcgaa gaagataagg atgatgaggt
     9781 cttagaaaaa gtctccttga aaaatgtttt tgaagaggat tacggactca agccagtctg
     9841 gacgaaagga aatttccccc ttgtcaagca tacttttagc catcaaaaat ggcaggttag
     9901 tctgcttgaa gggcaaattg accaaacaga cttaaaagga gacaaggact tgtgctgggt
     9961 tgctccagaa gattttgtca attatcctat ggcaactccc cagaaaaaaa tgattgaggc
    10021 ctaccagcaa aaagattaaa ctagaatttc tcatcatcta ggtgggattg tcaagggaaa
    10081 gctgtcttga atttttggcc tccccttagt ctgccaaaga tagaaccaag ttagactagc
    10141 tggaattttg ctatattcta aaaatgtaaa gccagcaaag cagatctatg ctataataga
    10201 ggcgatataa aaacacagtt gcagttgggt agtctgcaag cacctttggt gtcagtaacc
    10261 ttccctccag gtcgtccctt atcaaatttt atcttttttg gagggctggc atgaaaatga
    10321 cagtatattt cgacggcggt ttctggtttg ccttgcttga atatcaagat aagaaactgg
    10381 gctatcaggc tttccgttat gcttttggta aggaacccaa ggacaaggaa gttctcaact
    10441 ttgtccaccg ccgcttgagc cactggatga gacgacaaga ggagctgggc ttggtcattg
    10501 atgagcccga caaatccatg agccataagt ctattaatcc caagcggatg caaagggagg
    10561 tcagcaaaca gatgaaaaag cctgtcctgt cctccaaggc tcaacaggcc atgcaggcca
    10621 gttatgaatt gctgaaacag aaaaagaagg catccaaacg ccagcaaaag caagagtaca
    10681 aggaaagaca gtttcaactc aaacaggaaa aacgtcgtca aaagaaaaag ggacactaa
//
