LOCUS       NZ_CP029491.1          23338 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  NZ_CP029491.1 Streptococcus sobrinus strain 10919 chromosome,
            complete genome.
ACCESSION   NZ_CP029491
VERSION     NZ_CP029491.1
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 6.1.1
            Run date     :: 2024-03-14 12:51:12
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 483057
            Orig. end    :: 506395
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..23338
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[493057:496395]"
                     /cutoff="20000"
                     /detection_rule="((((goadsporin_like or PF00881 or
                     TIGR03605) and (YcaO or TIGR03882 or TIGR03604)) or
                     TIGR03603 or TIGR03602) and not cyanobactin_synth)"
                     /neighbourhood="10000"
                     /product="LAP"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..13338
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="((((goadsporin_like or PF00881 or
                     TIGR03605) and (YcaO or TIGR03882 or TIGR03604)) or
                     TIGR03603 or TIGR03602) and not cyanobactin_synth)"
                     /neighbourhood="10000"
                     /product="LAP"
                     /protocluster_number="1"
     cand_cluster    1..23338
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="((((goadsporin_like or PF00881 or
                     TIGR03605) and (YcaO or TIGR03882 or TIGR03604)) or
                     TIGR03603 or TIGR03602) and not cyanobactin_synth)"
                     /detection_rules="((YcaO or TIGR03882) and ((thio_amide and
                     (PF06968 or PF04055 or PF07366)) or Lant_dehydr_C or
                     Lant_dehydr_N or PF07366 or PF06968 or PF04055) or
                     thiostrepton)"
                     /kind="chemical_hybrid"
                     /product="LAP"
                     /product="thiopeptide"
                     /protoclusters="1"
                     /protoclusters="2"
                     /tool="antismash"
     region          1..23338
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="LAP"
                     /product="thiopeptide"
                     /region_number="1"
                     /rules="((((goadsporin_like or PF00881 or TIGR03605) and
                     (YcaO or TIGR03882 or TIGR03604)) or TIGR03603 or
                     TIGR03602) and not cyanobactin_synth)"
                     /rules="((YcaO or TIGR03882) and ((thio_amide and (PF06968
                     or PF04055 or PF07366)) or Lant_dehydr_C or Lant_dehydr_N
                     or PF07366 or PF06968 or PF04055) or thiostrepton)"
                     /tool="antismash"
     protocluster    1..22542
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[493057:495599]"
                     /cutoff="20000"
                     /detection_rule="((YcaO or TIGR03882) and ((thio_amide and
                     (PF06968 or PF04055 or PF07366)) or Lant_dehydr_C or
                     Lant_dehydr_N or PF07366 or PF06968 or PF04055) or
                     thiostrepton)"
                     /neighbourhood="10000"
                     /product="thiopeptide"
                     /protocluster_number="2"
                     /tool="antismash"
     proto_core      10001..12542
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="((YcaO or TIGR03882) and ((thio_amide and
                     (PF06968 or PF04055 or PF07366)) or Lant_dehydr_C or
                     Lant_dehydr_N or PF07366 or PF06968 or PF04055) or
                     thiostrepton)"
                     /neighbourhood="10000"
                     /product="thiopeptide"
                     /protocluster_number="2"
     CDS             450..998
                     /locus_tag="ctg1_443"
                     /transl_table=11
                     /translation="MEIRLAFPNEVESIMTIIEDAKNYLAQSGSDQWQSDYPNKETIFE
                     DVLQGRGWVGLEDGQLLAYAAVIDDHEPAYDAIYDGKWGHNNHRYITFHRLALAESARG
                     QGLAQTFLQGLIEGHDGPDFRCDTHEKNKAMQHILEKLGFHYCGKVVYEGERLAYQKIK
                     SKAERGFYQEVDEADHHAI"
     PFAM_domain     579..881
                     /aSDomain="Acetyltransf_1"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00583.27"
                     /description="Acetyltransferase (GNAT) family"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_443_0001"
                     /evalue="2.30E-07"
                     /label="ctg1_443"
                     /locus_tag="ctg1_443"
                     /protein_end="144"
                     /protein_start="43"
                     /score="31.2"
                     /tool="antismash"
                     /translation="FEDVLQGRGWVGLEDGQLLAYAAVIDDHEPAYDAIYDGKWGHNNH
                     RYITFHRLALAESARGQGLAQTFLQGLIEGHDGPDFRCDTHEKNKAMQHILEKLGF"
     CDS             1330..2508
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1072:dehydrogenase (Score: 220; E-value: 5.2e-67)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg1_444"
                     /transl_table=11
                     /translation="MVYSVKTFNNINQLGLKELGNKFQVDGDLAENPDAFIIRSQNLHG
                     MEFPANLKAIARAGAGTNNIPVADATENGVVVFNTPGANANAVKEAVVAAMLLSARDYI
                     SANAWVNTLSGDDVPKQVEAGKKQFAGSEIRGKTLGVIGLGAIGARIANDTRRLGMSVM
                     GYDPYVSIEAAWNISHHVKRVQDIKEIFANADYITIHVPLTDATRETFNADAFALMNKG
                     TTLINFARGELVNHQDLFEAIETGVVKRYITDFGDEDLLNKEGITVFPHLGGSTAEAEL
                     NCAKMASQEIRQFMETGEITNSVNFPNMHQALEALYRITLINRNVPNIVARISTAVSEA
                     NINIANILNRSKGDYAYTLLDLDENDRDKIDELVATFEASENIIKVRLIQKP"
     PFAM_domain     1609..2145
                     /aSDomain="2-Hacid_dh_C"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF02826.21"
                     /description="D-isomer specific 2-hydroxyacid
                     dehydrogenase, NAD binding domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_444_0002"
                     /evalue="3.00E-39"
                     /label="ctg1_444"
                     /locus_tag="ctg1_444"
                     /protein_end="272"
                     /protein_start="93"
                     /score="134.3"
                     /tool="antismash"
                     /translation="AAMLLSARDYISANAWVNTLSGDDVPKQVEAGKKQFAGSEIRGKT
                     LGVIGLGAIGARIANDTRRLGMSVMGYDPYVSIEAAWNISHHVKRVQDIKEIFANADYI
                     TIHVPLTDATRETFNADAFALMNKGTTLINFARGELVNHQDLFEAIETGVVKRYITDFG
                     DEDLLNKEGITVFPHL"
     CDS             2585..2815
                     /locus_tag="ctg1_445"
                     /transl_table=11
                     /translation="MDKQSLKAYQKSLGDRFYALSFKGQGTGFLGVSILYVDGETGIEY
                     LFVGMGGGSLTPLLNPDGSPKINERWRNGEL"
     PFAM_domain     2654..2788
                     /aSDomain="DUF6440"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF20037.1"
                     /description="Family of unknown function (DUF6440)"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_445_0003"
                     /evalue="2.90E-11"
                     /label="ctg1_445"
                     /locus_tag="ctg1_445"
                     /protein_end="68"
                     /protein_start="23"
                     /score="43.1"
                     /tool="antismash"
                     /translation="GQGTGFLGVSILYVDGETGIEYLFVGMGGGSLTPLLNPDGSPKIN
                     "
     CDS             2812..3306
                     /locus_tag="ctg1_446"
                     /transl_table=11
                     /translation="MIDKQIYQSPLGPISLLADDQDLLGCWFLGQKYFERGFEKEPLAE
                     ENSSVLTQAKSWLDAYFAGQNPQPADFLAPRGTTFQKQVWQVLREIPTGSSLTYGQIAG
                     RVNCRSAQAVGSAVGKNPLSIFIPCHRVLGSQGQLTGYAGGLDKKVWLLEHEGHVIKLR
                     K"
     aSDomain        3043..3279
                     /aSDomain="TIGR00589"
                     /aSTool="tigrfam"
                     /description="ogt: methylated-DNA--[protein]-cysteine
                     S-methyltransferase"
                     /detection="hmmscan"
                     /domain_id="TIGRFam_ctg1_446_0001"
                     /evalue="1.60E-31"
                     /identifier="TIGR00589"
                     /label="ctg1_446"
                     /locus_tag="ctg1_446"
                     /protein_end="156"
                     /protein_start="77"
                     /score="106.2"
                     /tool="antismash"
                     /translation="TTFQKQVWQVLREIPTGSSLTYGQIAGRVNCRSAQAVGSAVGKNP
                     LSIFIPCHRVLGSQGQLTGYAGGLDKKVWLLEHE"
     PFAM_domain     3049..3282
                     /aSDomain="DNA_binding_1"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF01035.22"
                     /description="6-O-methylguanine DNA methyltransferase, DNA
                     binding domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_446_0004"
                     /evalue="5.10E-31"
                     /label="ctg1_446"
                     /locus_tag="ctg1_446"
                     /protein_end="157"
                     /protein_start="79"
                     /score="106.6"
                     /tool="antismash"
                     /translation="FQKQVWQVLREIPTGSSLTYGQIAGRVNCRSAQAVGSAVGKNPLS
                     IFIPCHRVLGSQGQLTGYAGGLDKKVWLLEHEG"
     CDS             3321..3677
                     /locus_tag="ctg1_447"
                     /transl_table=11
                     /translation="MITFYHYPKCTTCQRAKKELDDLGISYQAIDLKENPPTAQTLGEL
                     LDSSDYKLKQLFNTSGNSYRTLGLKDKFASLTREEALDLLAADGMLIKRPLLVKDGKLL
                     QVGHRKSYRELGLK"
     aSDomain        3324..3650
                     /aSDomain="TIGR01617"
                     /aSTool="tigrfam"
                     /description="arsC_related: transcriptional regulator,
                     Spx/MgsR family"
                     /detection="hmmscan"
                     /domain_id="TIGRFam_ctg1_447_0002"
                     /evalue="5.90E-32"
                     /identifier="TIGR01617"
                     /label="ctg1_447"
                     /locus_tag="ctg1_447"
                     /protein_end="110"
                     /protein_start="1"
                     /score="108.4"
                     /tool="antismash"
                     /translation="ITFYHYPKCTTCQRAKKELDDLGISYQAIDLKENPPTAQTLGELL
                     DSSDYKLKQLFNTSGNSYRTLGLKDKFASLTREEALDLLAADGMLIKRPLLVKDGKLLQ
                     VGHRK"
     PFAM_domain     3333..3644
                     /aSDomain="ArsC"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF03960.17"
                     /description="ArsC family"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_447_0005"
                     /evalue="7.90E-16"
                     /label="ctg1_447"
                     /locus_tag="ctg1_447"
                     /protein_end="108"
                     /protein_start="4"
                     /score="58.0"
                     /tool="antismash"
                     /translation="YHYPKCTTCQRAKKELDDLGISYQAIDLKENPPTAQTLGELLDSS
                     DYKLKQLFNTSGNSYRTLGLKDKFASLTREEALDLLAADGMLIKRPLLVKDGKLLQVGH
                     "
     CDS             complement(3760..5532)
                     /gene_functions="transport (smcogs) SMCOG1005:Drug
                     resistance transporter, EmrB/QacA (Score: 357.9; E-value:
                     1.1e-108)"
                     /gene_kind="transport"
                     /locus_tag="ctg1_448"
                     /transl_table=11
                     /translation="MTNTRKVFGFTGLVLAMFMGALDATIVNIALPDIMKDLKTGLTDT
                     SWVATIYVLAMAVFIITVSKLADIYGRKLLMLIGVLLFGGFSFACMTAHTIPLLISYRF
                     FQGVGGAILTPIVLPMGIELFGKKNTSKVTAIIGAFSALAAAGGPVIGGLIIHLSNYRW
                     IFGINIPIALIALILIAFGTCESFDKSVSKHIDWFGMLFLTSCLAGVTFGLLEGHDYGW
                     SSPTIITSFVLSAISLIVLLVIERFVKSPIIDLQLFKEKTFSASSLIYLIFGFAIIIPS
                     LILNYFLQNVRSYSALHSAYLIVPASLAIAVGMPLATKLYQKISSKLLIGIGIVITAGG
                     LAMLSCIQYETSRDFIIACNVIIGFGLGFMAMALTASVKYLPVNKTGIGSGIVNAARYI
                     GQALGMAILVSLLSANVNTAKNSIRSDAYRQINKSHVSSQVKSVAKREIKKAFKTSDSS
                     SKISTQKNSMIKPIKQEAKKDSNLPIPKKGSDHRKLYDAMTKLEKGTNTLNEVLPSQLM
                     PVKTSLRQLGQGQTKVTTAIKLLAQKDELSSVFNHIVKTKNHELSRAFSHVYLTGMILL
                     LLCLPLTIYTERKV"
     aSDomain        complement(4192..5505)
                     /aSDomain="TIGR00711"
                     /aSTool="tigrfam"
                     /description="efflux_EmrB: drug resistance MFS transporter,
                     drug:H+ antiporter-2 (14 Spanner) (DHA2) family"
                     /detection="hmmscan"
                     /domain_id="TIGRFam_ctg1_448_0003"
                     /evalue="7.10E-79"
                     /identifier="TIGR00711"
                     /label="ctg1_448"
                     /locus_tag="ctg1_448"
                     /protein_end="447"
                     /protein_start="9"
                     /score="263.7"
                     /tool="antismash"
                     /translation="FTGLVLAMFMGALDATIVNIALPDIMKDLKTGLTDTSWVATIYVL
                     AMAVFIITVSKLADIYGRKLLMLIGVLLFGGFSFACMTAHTIPLLISYRFFQGVGGAIL
                     TPIVLPMGIELFGKKNTSKVTAIIGAFSALAAAGGPVIGGLIIHLSNYRWIFGINIPIA
                     LIALILIAFGTCESFDKSVSKHIDWFGMLFLTSCLAGVTFGLLEGHDYGWSSPTIITSF
                     VLSAISLIVLLVIERFVKSPIIDLQLFKEKTFSASSLIYLIFGFAIIIPSLILNYFLQN
                     VRSYSALHSAYLIVPASLAIAVGMPLATKLYQKISSKLLIGIGIVITAGGLAMLSCIQY
                     ETSRDFIIACNVIIGFGLGFMAMALTASVKYLPVNKTGIGSGIVNAARYIGQALGMAIL
                     VSLLSANVNTAKNSIRSDAYRQINKSHVSSQVKSVAKRE"
     PFAM_domain     complement(4318..5496)
                     /aSDomain="MFS_1"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF07690.18"
                     /description="Major Facilitator Superfamily"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_448_0006"
                     /evalue="2.40E-45"
                     /label="ctg1_448"
                     /locus_tag="ctg1_448"
                     /protein_end="405"
                     /protein_start="12"
                     /score="155.1"
                     /tool="antismash"
                     /translation="LVLAMFMGALDATIVNIALPDIMKDLKTGLTDTSWVATIYVLAMA
                     VFIITVSKLADIYGRKLLMLIGVLLFGGFSFACMTAHTIPLLISYRFFQGVGGAILTPI
                     VLPMGIELFGKKNTSKVTAIIGAFSALAAAGGPVIGGLIIHLSNYRWIFGINIPIALIA
                     LILIAFGTCESFDKSVSKHIDWFGMLFLTSCLAGVTFGLLEGHDYGWSSPTIITSFVLS
                     AISLIVLLVIERFVKSPIIDLQLFKEKTFSASSLIYLIFGFAIIIPSLILNYFLQNVRS
                     YSALHSAYLIVPASLAIAVGMPLATKLYQKISSKLLIGIGIVITAGGLAMLSCIQYETS
                     RDFIIACNVIIGFGLGFMAMALTASVKYLPVNKTGIGSGIVNAARYIGQALGM"
     CDS             5725..6063
                     /locus_tag="ctg1_449"
                     /transl_table=11
                     /translation="MQRQTTSVQDIKEALTNLLLIKKYNDIRVSDITREAGVSRGTFYQ
                     HFLDKDDLANEIGLETTTKFQEILSGGNLDNYKKVMEALIEIKKDYKHFKAIYLAQHLI
                     FQRLCKNL"
     PFAM_domain     5794..5895
                     /aSDomain="TetR_N"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00440.25"
                     /description="Bacterial regulatory proteins, tetR family"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_449_0007"
                     /evalue="4.30E-09"
                     /label="ctg1_449"
                     /locus_tag="ctg1_449"
                     /protein_end="57"
                     /protein_start="23"
                     /score="36.1"
                     /tool="antismash"
                     /translation="YNDIRVSDITREAGVSRGTFYQHFLDKDDLANEI"
     CDS             6369..6557
                     /locus_tag="ctg1_450"
                     /transl_table=11
                     /translation="MEVTYSASYIRLHQQCIIHSYYLSQDQLTKPVIKNMDDFYKAYDI
                     KKGDKMYMDRQDRLTIW"
     CDS             6897..7760
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) TIGR01716"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg1_451"
                     /sec_met_domain="TIGR01716 (E-value: 4.9e-62, bitscore:
                     206.3, seeds: 14, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLGKSLELGELYRELRIARGLKQRDVARDNLSVSQLSKFENGQSM
                     LAADKLLLAIQGIHMTFSEFSYALTQYQESDLFKMGKKLVEFQAKKDIDSLKKILADYH
                     NEETYEVYNQLNKLVIKATIYSLDSNLEITSEEKEFLTSYLYAIEEWTEYELYLFGNTL
                     FILSDDDLIFLGKAFVERDELYRELPEHKRRAELVLINLILILVEHRNIYHASYFIEKL
                     EALLSYQDMFARVVLIFLKKVMNYIKGETTDLSEVDAYISLVESFDNPILVMFLRTNLK
                     QIIKEN"
     aSDomain        7095..7751
                     /aSDomain="TIGR01716"
                     /aSTool="tigrfam"
                     /description="RGG_Cterm: transcriptional activator,
                     Rgg/GadR/MutR family, C-terminal domain"
                     /detection="hmmscan"
                     /domain_id="TIGRFam_ctg1_451_0004"
                     /evalue="1.10E-61"
                     /identifier="TIGR01716"
                     /label="ctg1_451"
                     /locus_tag="ctg1_451"
                     /protein_end="285"
                     /protein_start="66"
                     /score="206.3"
                     /tool="antismash"
                     /translation="YALTQYQESDLFKMGKKLVEFQAKKDIDSLKKILADYHNEETYEV
                     YNQLNKLVIKATIYSLDSNLEITSEEKEFLTSYLYAIEEWTEYELYLFGNTLFILSDDD
                     LIFLGKAFVERDELYRELPEHKRRAELVLINLILILVEHRNIYHASYFIEKLEALLSYQ
                     DMFARVVLIFLKKVMNYIKGETTDLSEVDAYISLVESFDNPILVMFLRTNLKQIIK"
     CDS             8174..8344
                     /locus_tag="ctg1_452"
                     /transl_table=11
                     /translation="MVSLTENEQNTLDELTQLDLTVLDLDESELVSAAAASSGSSSSCS
                     ISTCGSSSCCA"
     PFAM_domain     8228..8335
                     /aSDomain="Thiopep_pre"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF19409.1"
                     /description="Thiopeptide-type bacteriocin precursor"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_452_0008"
                     /evalue="2.50E-09"
                     /label="ctg1_452"
                     /locus_tag="ctg1_452"
                     /protein_end="54"
                     /protein_start="18"
                     /score="36.9"
                     /tool="antismash"
                     /translation="DLTVLDLDESELVSAAAASSGSSSSCSISTCGSSSC"
     CDS             8423..9358
                     /locus_tag="ctg1_453"
                     /transl_table=11
                     /translation="MKELYIIFESYEDLFRVQQRYFLSNFINQGMILFSKSSTKKSLTF
                     VSEDCREFDTLLGINRQCTRVDISDFNSKIYFPYFLDTDFFVKNYKLFFQGVVSLIQES
                     DYWDLDTEHKRYLIEELLCTVADQHTDGVSHGYLSFYSNYLYYLSQLRAIADKKSYQKI
                     KKRIEFVSDLDRGHFKEELVTFPKLSKNLGMVNKELVKNVEKLDLRQLPSPYDFFKNSK
                     VHLEYSEFHKNVFSNPLLLKRYSDIHFVSYRIIMGFFFKVLPLLGISLNERNHILYLFV
                     RHVEEYFNVDWKKQINESIKWEECNVNPKR"
     CDS             9339..9998
                     /locus_tag="ctg1_454"
                     /transl_table=11
                     /translation="MLIRRDNNKLLLLDKAKLLSVKANDFSEHIVDNKIIKIADNKKKN
                     YVEFESFYWDDNFRENSYSFSEKQDLIKKLEINMGSLLTYEDILDSNNSQYPLFNLKFN
                     DTLLIGHSLQNIYIDYFIRLLVGEVLEVIIDKSDFELYKKALLANNYEPPETNYGSRSK
                     KFNNLVEKQDFDIILSRNCQRAGEFKIEGIIKGKMKIEKITLFNQFEFLVIRDGEN"
     CDS             10001..11677
                     /gene_functions="biosynthetic (rule-based-clusters)
                     thiopeptide: YcaO"
                     /gene_functions="biosynthetic (rule-based-clusters) LAP:
                     YcaO"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg1_455"
                     /sec_met_domain="YcaO (E-value: 1.3e-47, bitscore: 160.0,
                     seeds: 127, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDYLFDKDKINWEKLDNCVKEADVLVPVPDAFIGFKKRKNLKESV
                     EYFRESLQKLGTNHWINFFYDADFTEFKEEIKNPLFLDVELTKDISLFSTEGLLIDSFN
                     LLKEEFSDEREEVDFNEVLDNGKNQLLSESNYRLESTFEIGKQAEEFLEHHVLGSYHLD
                     PAAAPFTGVSFEYKTPSYRKYNYGYGRAFDFLTAKNIASLEAVERFASEFYAFNYKNLA
                     KKSTYEELKTEYNVLPVSEIPLEANSKINNNTSLFWLKGQDIKKDKEIFIPEDLVYYGN
                     YPSREGYMRRLNDSSNGVALGSNYTETMISALLELIERHSFLMTWYGKVPGKRLVDYDD
                     LITDKERKVVDKIEKIGARVNLFEISVFKGVYVVWGLIMNDTDGAIITTYTSAGAGFTL
                     SEAIRAALMEVAVGYLVQGNTHETTPDLPKKIQTMDDHIDFYANPLSRKEFDFIDRFPK
                     YKIIKQEPNLLKICGTQEELVEHLLNVTLKGYKRIIFVNLTSKEMSSRGLYVVKAIIPE
                     FLPMTFGDGNLRINLDYINKSRAELGLDKISSYSSRPHPFP"
     PFAM_domain     10565..11554
                     /aSDomain="YcaO"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF02624.18"
                     /description="YcaO cyclodehydratase, ATP-ad Mg2+-binding"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_455_0009"
                     /evalue="2.70E-46"
                     /label="ctg1_455"
                     /locus_tag="ctg1_455"
                     /protein_end="518"
                     /protein_start="188"
                     /score="158.5"
                     /tool="antismash"
                     /translation="GRAFDFLTAKNIASLEAVERFASEFYAFNYKNLAKKSTYEELKTE
                     YNVLPVSEIPLEANSKINNNTSLFWLKGQDIKKDKEIFIPEDLVYYGNYPSREGYMRRL
                     NDSSNGVALGSNYTETMISALLELIERHSFLMTWYGKVPGKRLVDYDDLITDKERKVVD
                     KIEKIGARVNLFEISVFKGVYVVWGLIMNDTDGAIITTYTSAGAGFTLSEAIRAALMEV
                     AVGYLVQGNTHETTPDLPKKIQTMDDHIDFYANPLSRKEFDFIDRFPKYKIIKQEPNLL
                     KICGTQEELVEHLLNVTLKGYKRIIFVNLTSKEMSSRGLYVVKAIIPEF"
     CDS             11694..12542
                     /gene_functions="biosynthetic (rule-based-clusters)
                     thiopeptide: Lant_dehydr_C"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg1_456"
                     /sec_met_domain="Lant_dehydr_C (E-value: 1e-24, bitscore:
                     84.5, seeds: 35, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MQTIWKSYHVFMWNYEVFDDFIRAFYKLLTKQQKENIFFIRYWKG
                     GPHLRIRIKKENSEIVRSLIEDALQVISEQYPGLNNITLNKNDFYETTFMDGESFDLKN
                     LPWFKNLSIVEIPYVREVERYGGTDLMAQTERIFCMSSIIVSHLIKRPLLLSQKIVILY
                     RTVELVVENILTSQNDKIRYYSMSSRFWKSLERVESIDIETSEKIYQISHNLNLLSLLS
                     EFISGLKAIYLEVLKQDQEYAMSVVMSHLHMFANRLGVSIDTELSCYNYFREKERYDAV
                     G"
     PFAM_domain     11706..12503
                     /aSDomain="Lant_dehydr_C"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF14028.8"
                     /description="Lantibiotic biosynthesis dehydratase C-term"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_456_0010"
                     /evalue="2.60E-27"
                     /label="ctg1_456"
                     /locus_tag="ctg1_456"
                     /protein_end="270"
                     /protein_start="4"
                     /score="96.4"
                     /tool="antismash"
                     /translation="WKSYHVFMWNYEVFDDFIRAFYKLLTKQQKENIFFIRYWKGGPHL
                     RIRIKKENSEIVRSLIEDALQVISEQYPGLNNITLNKNDFYETTFMDGESFDLKNLPWF
                     KNLSIVEIPYVREVERYGGTDLMAQTERIFCMSSIIVSHLIKRPLLLSQKIVILYRTVE
                     LVVENILTSQNDKIRYYSMSSRFWKSLERVESIDIETSEKIYQISHNLNLLSLLSEFIS
                     GLKAIYLEVLKQDQEYAMSVVMSHLHMFANRLGVSIDTELSCYN"
     aSDomain        12039..12512
                     /aSDomain="TIGR03891"
                     /aSTool="tigrfam"
                     /description="thiopep_ocin: thiopeptide-type bacteriocin
                     biosynthesis domain"
                     /detection="hmmscan"
                     /domain_id="TIGRFam_ctg1_456_0005"
                     /evalue="4.80E-15"
                     /identifier="TIGR03891"
                     /label="ctg1_456"
                     /locus_tag="ctg1_456"
                     /protein_end="273"
                     /protein_start="115"
                     /score="54.1"
                     /tool="antismash"
                     /translation="IPYVREVERYGGTDLMAQTERIFCMSSIIVSHLIKRPLLLSQKIV
                     ILYRTVELVVENILTSQNDKIRYYSMSSRFWKSLERVESIDIETSEKIYQISHNLNLLS
                     LLSEFISGLKAIYLEVLKQDQEYAMSVVMSHLHMFANRLGVSIDTELSCYNYFR"
     CDS             12529..13338
                     /gene_functions="biosynthetic (rule-based-clusters) LAP:
                     PF00881"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg1_457"
                     /sec_met_domain="PF00881 (E-value: 1.4e-07, bitscore: 28.6,
                     seeds: 78, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLLDDRYFVNKKKNYNYLVKQNLRDAQNYSGWLMNFAPTGNLNLK
                     FETEITNVTRSKNYWDIDTSAIKFIDDLSYTLENRCSTPVANLDSEWSEEEVLFLLNKS
                     IGNGKRGKVYQDSYIPLRNYPSGGAQYPIKLYLVMNKNIDFFKSSRSYEIHPDLGIITE
                     VEVEDCKFEDIFAISHFNKETSEETKKLSFAIIMNMNLKHSFKKYKYYSKQLAMLEAGH
                     IAQNLQLVSTGLGKKSLPNGGILSDFSKKIIGLEGSKDDIVVYGVTF"
     PFAM_domain     12892..13326
                     /aSDomain="Nitroreductase"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00881.26"
                     /description="Nitroreductase family"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_457_0011"
                     /evalue="5.30E-06"
                     /label="ctg1_457"
                     /locus_tag="ctg1_457"
                     /protein_end="266"
                     /protein_start="121"
                     /score="26.7"
                     /tool="antismash"
                     /translation="RNYPSGGAQYPIKLYLVMNKNIDFFKSSRSYEIHPDLGIITEVEV
                     EDCKFEDIFAISHFNKETSEETKKLSFAIIMNMNLKHSFKKYKYYSKQLAMLEAGHIAQ
                     NLQLVSTGLGKKSLPNGGILSDFSKKIIGLEGSKDDIVVYG"
     CDS             13339..14091
                     /locus_tag="ctg1_458"
                     /transl_table=11
                     /translation="MKQIYINPFYDVIINCDKEINIINKVSNRILFKGISEKSNGVEQQ
                     EKVLLKKIEKLFSKHLMVTKQEYQFLLDLKKYVDDIDNSIKEDVKFSHLFDDWLFSTQL
                     DKVEILDGEVQVKRLLSNDNATYQEAILEINLETDLDYNKLLLTLKHYKYVYICSVGDF
                     TTVGPFLEQSHLKIENFFEIFTNQEIDESFIDSSLEAGVKQFVNNLVYNMLVERISNFL
                     LAQSPFYNRKIYIKSNNRIELGEELALV"
     CDS             14233..15183
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1244:amidohydrolase (Score: 63.7; E-value: 2.3e-19)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg1_459"
                     /transl_table=11
                     /translation="VHNGKEGLVYSNCHPQTYIFDLAFRAEMDAIILPNNDAFHGCGHD
                     LHMTSLIQLMAFLKIFPSSRKILFVFQSSEEAGNGAKNMVNTLNHKGVRVNKIIGLHNA
                     PDILVEDLAIKKNETLSNNFTNRLTIQFYEEERYDYHMPKNPLSNWSEIYSKITTLYNH
                     LSGVLFRIGEFRSNGQTGIQADELSFSLSIRSNELPLKSLYELFDELVVEIQDLNYVKH
                     LFVENINYHWRIYNSPKIYEIIKNNRLFNTLEIPDSFTSDDFCYYEGIAQEIFYLFLGS
                     FENAVVSKTHTKIFRPNLDFLNNSLKLYKFLLEEM"
     PFAM_domain     14335..15078
                     /aSDomain="Peptidase_M20"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF01546.30"
                     /description="Peptidase family M20/M25/M40"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_459_0012"
                     /evalue="2.60E-13"
                     /label="ctg1_459"
                     /locus_tag="ctg1_459"
                     /protein_end="282"
                     /protein_start="34"
                     /score="50.2"
                     /tool="antismash"
                     /translation="NNDAFHGCGHDLHMTSLIQLMAFLKIFPSSRKILFVFQSSEEAGN
                     GAKNMVNTLNHKGVRVNKIIGLHNAPDILVEDLAIKKNETLSNNFTNRLTIQFYEEERY
                     DYHMPKNPLSNWSEIYSKITTLYNHLSGVLFRIGEFRSNGQTGIQADELSFSLSIRSNE
                     LPLKSLYELFDELVVEIQDLNYVKHLFVENINYHWRIYNSPKIYEIIKNNRLFNTLEIP
                     DSFTSDDFCYYEGIAQEIFYLFLGSF"
     CDS             15183..17552
                     /locus_tag="ctg1_460"
                     /transl_table=11
                     /translation="MYIFYRQNRKSVSDFINCFYEGETDDVIKQLQETDYRINEISKQL
                     INNIDDYIYKNELKYPDAKDYLTVKRKVKRRKVLKQQFEKIAEEIPFYNSLLALKIELE
                     EKVNKALESDYKKQVTEFPKLFSEEELLLFRNEHLKYKLMKQGNISLKKKDRISLYHYI
                     SQLSLKTGGVGFANSIGCFELGNSTHHMKPKQNYVVDIHNYLLNRLYFKVLKGNLSNFV
                     GSFLVNFNYVIDRKKSFVLFKVLLDDPDSNIFRGKEREVKLELTSPIKWLLTKDKISIQ
                     GLNEYFGNDEIIQLLNYGILRYAHLRPRDDFSWIDNFDILEPSLLAKLRQIGNLLQDLN
                     YQFSSVDFSRIVELITDLCQKYRVDTLGSPLLTIDTYKDSLDLSNQQVKFLKNFISKIR
                     SLSEFYSIFDASKRVEELAYNFMIYHYPEGKSFKNFMDLDEFFKELAEFVFEKINLGAL
                     RSGFFEFADYPLIAFIINKICSSNSQDFLFSEDDLEEILKKLKLNSYNSDHSYAFFVQT
                     GKEGVYLNHVYKGLGIFNNRYRDNFSANDFEQNYNFGRIFDTPYYFGFNANKRPERPSL
                     DMFGLSEYPKESELDYRDIMITVDSSKRCLRFLDNIGKEFYFSFLGNMTPIVFPKTLAM
                     FNSLSLTGGMYFDLSDLVLRKKYADNKDLNVFISPQIYFLDKEIIISRSKTLVRTTLLK
                     KIFNDSQNNAQILLGIKKIYPNSSLFVREFFVDSDFKSKIKKPLFVNLNSSIGLENFID
                     YVGKVDWVTLETPQPEFSQDHLTEFIVESKNTIPDK"
     CDS             17631..18305
                     /gene_functions="transport (smcogs) SMCOG1000:ABC
                     transporter ATP-binding protein (Score: 170.1; E-value:
                     1e-51)"
                     /gene_kind="transport"
                     /locus_tag="ctg1_461"
                     /transl_table=11
                     /translation="MFTLTNIEKTFGGTNKILQGISLSIEDGERIALLGSNGAGKTTLL
                     KIISGQLKQNKGTINSKLDFQSEIGMMPQGDILIDDLKVKEIVNLKAYMNRLREKNIDS
                     LLEKVDLKDQKDKFVSSLSGGQKRRLSLLLAILNNPKLIFLDEPTTGMDLESVDKFWEL
                     LKKQDVTSVIVTHDFNQIDKFFTRVLILKNGKIFADEKVEVIHQQGLTIEKFYRTINDK
                     EI"
     PFAM_domain     17682..18077
                     /aSDomain="ABC_tran"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00005.29"
                     /description="ABC transporter"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_461_0013"
                     /evalue="3.00E-31"
                     /label="ctg1_461"
                     /locus_tag="ctg1_461"
                     /protein_end="149"
                     /protein_start="17"
                     /score="108.9"
                     /tool="antismash"
                     /translation="LQGISLSIEDGERIALLGSNGAGKTTLLKIISGQLKQNKGTINSK
                     LDFQSEIGMMPQGDILIDDLKVKEIVNLKAYMNRLREKNIDSLLEKVDLKDQKDKFVSS
                     LSGGQKRRLSLLLAILNNPKLIFLDEPT"
     CDS             18307..19026
                     /locus_tag="ctg1_462"
                     /transl_table=11
                     /translation="MPKFIQLKQVIRNKRFLLFTIFIPIVWYAFLHNVQSISSNIILGI
                     AVFIGIIGNSLATFSKRISSNIDFYAFESRFTHYSIKNYLFDQTFIQIVLNTLIFFAIL
                     FSAVAFFKFPIASIVFVQFLLLMLMGIYFSIIGFVMGVRLDTKIIDTVSFPIIIVASLT
                     IIPFKNLGASGNFVDILSKIQMIFPGYYYSSIINALMKDNPVKTNDILLFLVTFFLNII
                     VLYFLIPHGQLKQRVAK"
     CDS             19587..20207
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_C39"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg1_463"
                     /sec_met_domain="Peptidase_C39 (E-value: 1.6e-14, bitscore:
                     50.8, seeds: 36, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKYYHTMQDLASDCGIAVVKSILLTYGRYDETLLTDRLQHLNIDQ
                     GLSLLDIEELLSIFGIYGSNYQVNEFSNLNFKTPCILVTRRDGINHYILGYGKQNDKLV
                     VSNPAEKTISYQSFEEVRDIFNGFAYIVESDDSKVVLKETSATSENDNNSLSFKERLSL
                     FFYDELTLANSLVYYFFYSIFNCFSRPRCKMRCNKKRQAYLIY"
     PFAM_domain     19593..19991
                     /aSDomain="Peptidase_C39"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF03412.17"
                     /description="Peptidase C39 family"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_463_0014"
                     /evalue="1.50E-13"
                     /label="ctg1_463"
                     /locus_tag="ctg1_463"
                     /protein_end="135"
                     /protein_start="2"
                     /score="50.8"
                     /tool="antismash"
                     /translation="YYHTMQDLASDCGIAVVKSILLTYGRYDETLLTDRLQHLNIDQGL
                     SLLDIEELLSIFGIYGSNYQVNEFSNLNFKTPCILVTRRDGINHYILGYGKQNDKLVVS
                     NPAEKTISYQSFEEVRDIFNGFAYIVESD"
     CDS             20242..21261
                     /locus_tag="ctg1_464"
                     /transl_table=11
                     /translation="MSTTNCTTKQPYCHLSEVERGKIEAFLSEGLKPAEIARRLGRSRS
                     TISREIKRGTTKQVKQVNGKKIYFDYYFADLAQRRYVEGQRGIDYLKLEKVSEHFLKAF
                     EEAMKASPRVHSVESFVYAYKEEHPSETVPSTKTLYNYSHQGLLAIKAIDFPKAVRLRK
                     KTKKRSSTQKHLGVSIEERPETINDRSVFGHWEIDSVLGTQKAGEPSILTLVERKTRYA
                     ITAYLAGKKAEDVNEAVAELIQQYPIKSITADNGSEFASLNELEGVQVYYAHAYSSYER
                     GTNENFNGLLREFVPKGKSLKTLTAEDLAKATLAINQRPRKLLNYQTAKTLFGLAQTA"
     PFAM_domain     20281..20403
                     /aSDomain="HTH_38"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF13936.8"
                     /description="Helix-turn-helix domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_464_0015"
                     /evalue="4.80E-14"
                     /label="ctg1_464"
                     /locus_tag="ctg1_464"
                     /protein_end="54"
                     /protein_start="13"
                     /score="51.9"
                     /tool="antismash"
                     /translation="HLSEVERGKIEAFLSEGLKPAEIARRLGRSRSTISREIKRG"
     CDS             21370..22701
                     /locus_tag="ctg1_465"
                     /transl_table=11
                     /translation="MNISTNHYKLRKVKKRWVTFVVTTMAGLTLMTAGASSASADSSTL
                     DSQVNQTSTLVQPTSDGTSVVAPSQEKVPSNPTEVKDTDNQSENQSQPTQAASLTTQED
                     DKEPTSQNNQAPADSPKQVKEPTSVAPASDGAVVQQEPQTQKQEEKTTGGKNEVTSTDA
                     VVTTAPTLTSDDQRADINKILDGRLSGISTLDAAALTYEFEKARLKGATDATILAKIQE
                     AGRVIPNNLTYLSDFYDNQTGTSGTAFRDKASNKVIIAYTGTNNDGNELQDALGADLMG
                     IGLARGQHYQPAYDFYDKIASQYGAEIIVITGHSLGGNVAQRVALKKNAATTVVYNSAP
                     LYIPALASVGNKIYESLRKNFDLPSNKAEAKKTIAAIRSDMKTFTGHVIRITTTKDWLN
                     NAMRWLGAVYLGKEYVIPDSGNHDLQPIAENAKQVASVKQWTTI"
     PFAM_domain     21382..21495
                     /aSDomain="KxYKxGKxW_sig"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF19258.1"
                     /description="KxYKxGKxW signal peptide"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_465_0016"
                     /evalue="3.20E-08"
                     /label="ctg1_465"
                     /locus_tag="ctg1_465"
                     /protein_end="42"
                     /protein_start="4"
                     /score="33.5"
                     /tool="antismash"
                     /translation="TNHYKLRKVKKRWVTFVVTTMAGLTLMTAGASSASADS"
     aSDomain        21385..21441
                     /aSDomain="TIGR03715"
                     /aSTool="tigrfam"
                     /description="KxYKxGKxW: KxYKxGKxW signal peptide"
                     /detection="hmmscan"
                     /domain_id="TIGRFam_ctg1_465_0006"
                     /evalue="1.50E-04"
                     /identifier="TIGR03715"
                     /label="ctg1_465"
                     /locus_tag="ctg1_465"
                     /protein_end="24"
                     /protein_start="5"
                     /score="19.3"
                     /tool="antismash"
                     /translation="NHYKLRKVKKRWVTFVVTT"
ORIGIN
        1 ggattcaagc agattccggt tccctctaca atacgccacc agcttataat atctatatcg
       61 ctaaattggt ctttgaatgg gtgaaaaaca ccatcggcgg tgtcgataag atggcccaaa
      121 tcaatcgtga aaaatctggc ctgctctacg attatattga gcaatcagat ttctacacca
      181 gccctgtcaa gaaggtcgag gatcgctccg ttaccaacat cccatttgtg accccaagta
      241 aggacttgga tgctgagttt gtcgctgagg ctgataaatt aggcttcaag aatatcaagg
      301 gtcaccgtag cgtcggcggt atgcgggcta gtctctacaa cgctttccca agacaaggcg
      361 ttttggacct gattgacttt atgaaggact ttgaagcccg ccatcaataa aagtaggagt
      421 accaccttca cttatatcta aggagaatca tggaaattcg tttagccttt cccaatgaag
      481 tggaaagcat catgaccatc attgaagatg ccaaaaacta cctggctcaa tccggtagtg
      541 accagtggca gtctgactat cccaataaag agaccatttt tgaggatgtt ctccaaggac
      601 ggggctgggt tggccttgaa gatggtcaac tgttggccta cgctgctgtg attgatgacc
      661 atgaaccagc ctatgatgcc atctacgatg gcaagtgggg gcacaataat caccgctata
      721 tcacctttca tcgcctggcc ctagccgaat ctgcccgagg tcaaggtctg gctcagacct
      781 tcttgcaggg gctgattgaa ggccacgatg gccctgattt tcgctgtgat acccatgaga
      841 aaaacaaggc tatgcagcac atcttagaaa agttgggctt tcattactgt ggcaaggtcg
      901 tctatgaagg tgaacgtctg gcctatcaaa agattaagtc aaaggctgaa agaggcttct
      961 atcaagaagt ggacgaggct gaccaccacg ccatctaatc aggcagaaat agctatccaa
     1021 ttccaaatga ggatagctat tttcatagaa ttctagataa gcatcaaaac tgaaagtcta
     1081 tttaagaaaa atcaattgtt tttggaatta agtctaacga agtgaggaaa acctgatatt
     1141 ttcgccgtag tggcattatt agcaacaaaa gtcttgttgc taataacgga ttttttgaga
     1201 ccttaggctc aaaaaatagg aatggaacgc caatggcggt cgcttccgtc cgcactacct
     1261 cagaaaatat caaaaaatga cttttgattt ttaataagtg tagaattttt caattaaaaa
     1321 ggagaaaata tggtttatag tgtcaaaacc tttaacaata ttaatcaact gggcctcaag
     1381 gaattgggca ataagtttca ggtagacggt gatttggcag aaaatcccga tgcctttatt
     1441 atccgcagtc aaaatctgca cggcatggag tttccagcca acctaaaagc catcgctcga
     1501 gccggggcgg gcaccaataa tatccccgtt gcggatgcga ccgaaaatgg ggtcgtggtt
     1561 ttcaataccc caggtgccaa tgccaatgcc gtcaaagaag ctgttgtcgc tgccatgttg
     1621 ctatctgcca gggattatat ctctgccaat gcttgggtca ataccctttc tggtgacgat
     1681 gttcccaaac aagttgaagc aggtaagaag cagtttgctg gtagtgaaat tcgtggcaaa
     1741 acccttggtg tcatcggtct tggtgccatc ggagctcgga ttgccaacga tacccgccgt
     1801 ctagggatgt ccgtcatggg ttatgacccc tatgtctcta ttgaagccgc ttggaatatt
     1861 tcccatcatg tcaagcgagt gcaggacatc aaggaaattt ttgccaatgc cgactacatt
     1921 accatccatg ttcctctgac agatgccact cgtgagacct tcaatgccga tgcctttgct
     1981 ctcatgaata agggaacgac cctgatcaat tttgctcggg gcgagctggt caatcaccag
     2041 gacctatttg aagccattga aacgggcgtg gtcaaacgct atatcaccga ctttggtgat
     2101 gaagacctcc tcaataagga agggattacg gttttccctc acctcggtgg ttcgaccgca
     2161 gaagcagagc tcaactgtgc caagatggcc agtcaagaaa ttcgccagtt catggaaacc
     2221 ggtgaaatta ccaactcagt caattttcca aatatgcacc aggccctgga agccctttac
     2281 cgtatcaccc tgattaatcg caatgtccca aatattgtgg cccggatttc aacggcagtt
     2341 tctgaggcta atatcaatat cgccaacatc ctcaaccgct ctaaaggcga ctatgcctat
     2401 actctgttgg acctagacga aaacgaccgt gacaagattg atgagctggt ggccaccttt
     2461 gaagctagtg aaaatatcat caaggtgcgt ctgattcaaa agccctgaat aaacagacca
     2521 agcagcatcc cctaaagatg ctgttttttg atacaatagg gataatttat taggaggtat
     2581 taggatggat aaacaatcat taaaagctta tcaaaaatca ttgggagatc ggttttacgc
     2641 cctcagtttt aaaggtcaag gaaccggttt tcttggagta agcattttat atgtggacgg
     2701 cgaaacgggt attgaatatc tttttgttgg gatgggaggc ggtagtctga ctccactgct
     2761 caatcctgat ggcagtccta aaatcaatga aagatggcgt aatggcgagc tatgattgac
     2821 aagcaaatct accagtcccc tcttggcccc atttctcttc tagctgatga ccaggacctg
     2881 ctgggctgct ggtttctcgg tcaaaaatac tttgagcgag gctttgaaaa ggagcctctg
     2941 gcggaggaga actcgtcagt tttaacccag gctaagtcct ggcttgatgc ctattttgct
     3001 ggtcaaaatc ctcagcctgc tgattttcta gctccaagag ggaccacttt tcagaagcaa
     3061 gtctggcagg ttctaagaga aattccgacc ggttccagtc tgacctatgg acagatagca
     3121 gggcgtgtaa actgtcgctc cgcccaagct gtgggctcag ctgtcggcaa gaatcccctt
     3181 agtatcttta tcccctgcca ccgagtccta ggttctcaag gccagctgac tggttatgct
     3241 ggtggtctgg acaagaaagt ctggttgctg gagcacgagg gccatgttat taaattgaga
     3301 aaataaggaa ggaaagaaaa atgattactt tttaccatta tcctaaatgc acaacctgcc
     3361 aaagagccaa aaaggagctg gatgacttag gcatttccta ccaggccatt gacctcaagg
     3421 aaaatccacc gactgctcaa actctgggag agctcctaga ctcatccgat tacaagctca
     3481 aacaactctt taacaccagt ggtaacagct atcggacctt gggtctcaag gataaatttg
     3541 ccagcctaac tagagaagaa gcactggacc tcctagcagc tgatggcatg ctgatcaagc
     3601 gtcccctcct ggtcaaggat ggtaaactcc tccaagtcgg ccatcggaag tcgtataggg
     3661 agttggggtt gaaataaata agcccatctc ggctaaactg agatgggtat ttatataata
     3721 atttacttta gcctccttat attgaaactc gtaacaccat tagacctttc tttccgtata
     3781 aattgtcaga gggagacata aaagtagtaa aatcattcca gtcagataaa cgtgtgaaaa
     3841 tgccctactt aattcatgat tttttgtttt tacaatatga ttgaaaacac ttgatagttc
     3901 atctttttga gctagtaatt taatagccgt cgtgactttt gtttgtccct gtcccagttg
     3961 ccttaagctt gttttaactg gcattagctg agaaggtaga acttcattta gggtgtttgt
     4021 gcctttttcg agcttagtca ttgcatcata aagttttcta tgatctgacc ctttctttgg
     4081 aataggtagg ttactatctt tcttggcttc ttgtttgata ggcttaatca tgctattctt
     4141 ttgagttgaa atttttgagc ttgagtctga ggttttaaag gcttttttga tttctctttt
     4201 agcgactgat tttacttgcg atgaaacatg actcttatta atttggcgat aggcgtcact
     4261 tctaatcgag ttcttagctg tattgacatt agcacttaga agtgacacta gaatagccat
     4321 acccaaggct tggccaatat agcgagcagc attaacaatt ccagatccaa ttcctgtttt
     4381 attgactggt aaatatttta ccgaagctgt gagtgccatc gccataaagc cgagaccaaa
     4441 gccgataata acattacagg ctatgatgaa gtcccttgat gtttcgtatt gaatgcaact
     4501 tagcattgca agtccaccgg ctgtaattac gatgccgatt ccaatcaata gtttactgga
     4561 aatcttttga tataatttag ttgctagagg catacctact gcaatggcta gggaggctgg
     4621 aacgattaga taggcagagt gcaaagctga gtaggaacga acattttgta ggaaataatt
     4681 taggataagc gaaggaataa taattgcaaa tccaaaaatt aaataaatta gacttgatgc
     4741 tgagaatgtt ttttctttaa aaagttgtaa atcaataatt ggggatttta caaatcgctc
     4801 aatgaccagt agtacaatca agctgatagc acttaaaaca aaactggtaa taatagttgg
     4861 agaagaccat ccataatcgt gtccttctaa tagtccaaat gttaccccag ctaaacagct
     4921 tgttaagaac aacattccaa accaatcgat atgtttagag acgcttttat caaatgattc
     4981 acatgttcca aaagctatta aaataagcgc aattagggca atgggaatat tgattccaaa
     5041 aatccaccga tagttggaca aatgaatgat tagtccgccg atgacgggtc cgccagcagc
     5101 ggctaaagca ctaaaagcac caatgatggc agtgacctta cttgtattct ttttaccaaa
     5161 gagttcaatt cccataggta gaacaatagg tgtcaaaata gccccaccga ctccttggaa
     5221 aaatctataa gaaattaaaa gagggatggt atgggctgtc atacatgcga aggagaagcc
     5281 tccaaaaagg agcaccccaa ttagcattaa taatttccga ccataaatat ctgctaattt
     5341 tgataccgta ataataaata cggccatggc tagcacatag atagtcgcta cccaactagt
     5401 atctgtcaat ccagttttca aatctttcat gatgtctggc aaagctatgt ttacaattgt
     5461 tgcatctagt gcccccataa acatggctaa aacaagccct gtgaacccaa aaactttcct
     5521 tgtatttgtc ataagttaag taatcctttc tattttttac ggaatggcca accgttttcc
     5581 cgttgaaggg aataaatttt agaaattaaa aagaatgtat agaaatttag ttattcttct
     5641 caataatttc tgccaaaata atacaataca ggttggctat ttactatgac agaagtaaag
     5701 aaactgttca attaaggaga aaaaatgcaa agacaaacaa ccagtgttca agatattaaa
     5761 gaggccctga ctaatctcct cttaataaaa aaatataatg atattcgagt tagtgatatt
     5821 accagggaag ctggtgtcag cagaggaacc ttttatcagc attttttaga taaggatgat
     5881 ttagctaatg aaattggcct tgagacgact accaaatttc aagaaatcct ctctggggga
     5941 aatctggata attacaagaa agtcatggaa gcacttatag aaatcaagaa agattataag
     6001 cattttaaag ccatttattt agcacagcat cttatttttc aaagattgtg caagaactta
     6061 tagtaagtat catttctaaa aacactagtt tgcgaaatag gatattccgt catagtggta
     6121 taaataatcc gattattctc caagctttta gtgcttcatt tgagcgtatc ttgtcaatat
     6181 ggattgagca tgatttggtt gaaccacctg agaagattgc agaggcaatt atgaagattg
     6241 aaggcttgtt ctggggagag atgtaagaca aatattttct cccaaagtat ttttacagta
     6301 tgagatagaa aagccccccc agtttaattt gatgggagtg ctttgtcttt ttaatgtagt
     6361 aaaagattat ggaagtaacc tatagtgcta gttatattcg acttcatcaa cagtgtataa
     6421 ttcacagtta ttatctttca caggaccagc taactaagcc tgtcattaag aatatggacg
     6481 acttctacaa ggcctatgat attaaaaagg gcgacaagat gtatatggac aggcaggacc
     6541 gtctgaccat ctggtgattg cctgatatat gaaaaaattc ctactcgttt ggggcaggaa
     6601 tttttaatag cttttagcaa aatgaggcga gaagcgatat aagggtcgcg ttattaatgc
     6661 ggttaaggcc aaggtctggc ttagacctcc tagtagccga tggcgtggtt ccctcctagt
     6721 taaggacggc aaactcctgc aagtcggaca tcgtaagtct tataaggagt tggaactaaa
     6781 ttaaattttt agaattagta cgcgttatta tctttttcta agtttttata ttaccttagt
     6841 tacaaacctg aaaaatatga tacgattgtt gtaatgaata gttaggagga actataatgc
     6901 ttggcaaatc acttgaacta ggtgaacttt atagagaatt gcggatagct agagggttaa
     6961 agcaaagaga tgttgctagg gataatttat ctgtctccca attatcaaag tttgaaaatg
     7021 gacagtctat gttagcagct gacaaacttc ttttagctat ccagggaatt catatgacct
     7081 tttccgagtt cagctatgca ttgactcaat atcaggaatc tgatttattt aaaatgggta
     7141 agaaactagt ggagtttcag gctaaaaagg atattgatag cttaaaaaaa attttagcag
     7201 actatcataa tgaagaaact tacgaggtct ataatcaact taacaaacta gttattaaag
     7261 ctactatcta tagtttagat tctaatttag aaattactag cgaagaaaag gaatttctaa
     7321 cttcgtacct ctatgctatc gaagagtgga cggagtatga actctatctt tttggtaata
     7381 ccctatttat cttatcggat gatgatttga tcttcttagg taaagcattt gtcgaacgag
     7441 atgaattata tagagagctt ccggagcata agagaagggc tgagcttgta ttaatcaatc
     7501 ttattttaat cttggtagaa catcgtaata tttaccatgc ttcttatttt attgaaaaac
     7561 ttgaggcact attatcttat caagatatgt tcgctagggt agtcttgatt tttttaaaaa
     7621 aagtaatgaa ctatattaag ggtgaaacaa ccgatttatc agaggtggat gcttatatta
     7681 gtctggttga aagttttgat aatcctatac tggtcatgtt tttgaggacg aatttgaaac
     7741 agattataaa agaaaattag ttttaaaaag aaaggagccc tgagtgttga cccagagctc
     7801 ctttttggga gaagtgaaac aagaaagtaa agtattatct ttcgctttgt tgattatagg
     7861 aatggtaaca acaaaaaagg aaaacacgac aaaagcgtaa ttagtttttt aagcatatta
     7921 atttatcctc cttattctta ttttatttta tattttacta gtaaaaagga gtaaaacgag
     7981 aaattcgcaa atatgaaaat aataattaaa aaaaagtcag atttgcgaat atctaagaat
     8041 cgataaaaga ggtgatacat tattcatgta aaatatttga tcaaaatttt acactttaaa
     8101 cttaataatt gttgttagtg tatgtaaagc tagctaatat tgcgctaata atagttatgg
     8161 aaaggagaaa cagatggtat ctttgactga aaacgaacaa aatactttgg acgagcttac
     8221 tcagttagat ttaacagttc ttgatttgga tgaatctgaa ctagtatctg ctgcagctgc
     8281 tagtagtgga agtagtagta gttgttcaat aagtacgtgt ggttcatcat cgtgctgcgc
     8341 ctaaatcgct caaaagtgtt ggagaggtat agtttgatac gatctcaaca cttttgattg
     8401 ttgaataagg agtaaggaaa atatgaaaga attatatatt atttttgagt cctatgaaga
     8461 cttatttcga gtacaacaga gatatttctt atcgaatttt attaatcaag gaatgatttt
     8521 attttcaaaa agtagtacga aaaaatcttt aacctttgtt agcgaagatt gtagagagtt
     8581 tgacacacta ttgggaatca atcggcaatg tacacgagta gatatatctg attttaattc
     8641 aaaaatttat tttccttatt ttttagatac ggatttcttt gtaaaaaact ataaattatt
     8701 ttttcaagga gtagtatccc ttattcaaga gtcagattat tgggacttag atactgaaca
     8761 taaacgatac ttgatagaag agttgctatg tacagtagct gatcagcata ctgacggtgt
     8821 tagccatgga tatttgtcat tttattctaa ctatttatat tatttaagcc aacttagagc
     8881 gatagctgat aaaaaaagtt accagaaaat caaaaaaaga attgaatttg taagtgattt
     8941 agatcgtggc cattttaagg aagaacttgt cacttttccc aaattgtcaa aaaatttagg
     9001 aatggttaat aaggaacttg taaaaaatgt tgaaaaactg gacctaaggc aattaccaag
     9061 tccgtatgat ttttttaaga atagcaaagt tcaccttgaa tactcagaat ttcacaaaaa
     9121 tgtatttagt aatcctttgc tattgaagag atatagcgat attcacttcg tatcttatag
     9181 aattataatg ggattctttt ttaaggtttt accattgtta gggataagtc taaatgagcg
     9241 aaatcatatt ctctatttat ttgttagaca tgtcgaagaa tattttaatg ttgattggaa
     9301 gaagcagata aatgagagca taaaatggga ggaatgtaat gttaatccga agagataata
     9361 acaaacttct tttgttagat aaagcgaaat tattgtcggt caaagcaaat gattttagcg
     9421 aacatatagt agataataag attattaaaa tagctgacaa taagaaaaag aattatgtag
     9481 aatttgagtc tttttattgg gatgataatt ttagagaaaa cagttattct ttttcagaaa
     9541 aacaagattt aattaaaaag ttagaaatta acatgggctc tttgcttaca tatgaggata
     9601 ttttggattc taacaattct caatatcctc tatttaattt aaaatttaac gacaccttgc
     9661 tgattggcca cagtttgcaa aatatttata ttgattattt tattcgttta ctggtcgggg
     9721 aagtcttaga agtaattatt gataagtctg attttgaact ctacaaaaaa gcattattag
     9781 ctaataatta tgaaccacct gaaactaact atggatcacg gagcaaaaaa tttaataatt
     9841 tagtggaaaa gcaggatttt gatattatcc taagccgaaa ttgtcagaga gcaggagagt
     9901 ttaagattga aggtattata aagggaaaaa tgaaaataga gaaaattact ctatttaatc
     9961 aatttgaatt tttagttatt cgggatggtg aaaattaatt atggattatc tctttgataa
    10021 agataaaatt aactgggaaa aactagataa ctgtgtaaaa gaggcagacg tccttgttcc
    10081 agtaccagat gcttttattg ggttcaagaa aagaaagaat ttaaaggaat ccgttgaata
    10141 ttttagagaa agtttacaaa agttaggaac taatcattgg ataaatttct tttatgatgc
    10201 agattttaca gagttcaaag aagaaataaa gaatccttta tttctagatg ttgaactaac
    10261 aaaagatatt tctttattct ctactgaagg acttttaatt gattccttta atcttttgaa
    10321 ggaggaattc tctgacgaac gggaagaagt tgactttaac gaagtattag ataatggtaa
    10381 gaatcaactg ttatcagagt ctaattaccg actggaatct acatttgaaa ttggaaaaca
    10441 ggcagaggag ttcttagaac atcatgtttt gggaagctat cacctagatc cggcagctgc
    10501 accttttaca ggagtatcgt tcgaatataa gacgcctagc tatagaaaat ataactatgg
    10561 atatggacga gcatttgatt ttttaacagc taaaaatatt gccagtcttg aggcagtgga
    10621 acgttttgca tcagaatttt atgcttttaa ctataaaaat ttagcaaaaa aatcgactta
    10681 tgaagaatta aagacggagt acaacgtctt gcctgtaagt gagatccctc ttgaggctaa
    10741 ttcgaaaatc aataataata cttcactttt ttggctgaag ggacaagata ttaaaaaaga
    10801 taaagaaatt tttatcccag aagatttggt atattatgga aattatccaa gtagagaagg
    10861 ttatatgcgt agactgaatg acagttcaaa tggtgtagca ctaggatcaa attatactga
    10921 aactatgata agtgctcttc ttgagttaat tgagcgccac agttttttaa tgacgtggta
    10981 tggtaaagtt cctggaaaaa gattagtgga ttatgatgat ctaataacag ataaggaaag
    11041 gaaggtagtt gataagattg aaaaaattgg agctagagta aatttatttg aaatctcggt
    11101 atttaaaggt gtttatgttg tgtggggact tataatgaat gatactgatg gagctatcat
    11161 taccacctac acttctgctg gagccggctt cactctttcg gaggcaatta gagcagcgct
    11221 tatggaagtg gctgtgggat atctagtaca aggaaatact catgagacga ctccagactt
    11281 gccaaaaaag attcaaacaa tggatgatca tattgatttt tatgccaacc cgctgagtag
    11341 aaaagaattt gactttattg ataggtttcc gaaatataaa attattaaac aagaacccaa
    11401 cttattaaaa atttgtggaa cacaggagga attagtggaa catttactta atgtaacgct
    11461 aaagggatat aagagaatta tttttgtaaa tttgacttct aaagagatgt cctcacgggg
    11521 actatacgtt gttaaagcta ttatcccaga atttttacca atgacttttg gcgatgggaa
    11581 tttaagaatt aacttagatt atattaataa atcaagggcg gagttgggtc tggataaaat
    11641 ttcatcctat agttctcgtc cacacccttt tccttaaatt agggaggaat attatgcaaa
    11701 ctatatggaa gtcttatcat gtttttatgt ggaattatga agtctttgat gactttatta
    11761 gagcgtttta taagttattg acaaaacaac agaaagaaaa tatttttttt attcgttact
    11821 ggaaaggtgg ccctcaccta aggattagaa taaaaaaaga aaattctgag atagtgcgtt
    11881 ctctgattga ggatgcatta caagtgattt ctgagcagta tcctgggttg aataatatta
    11941 cattaaataa aaatgatttt tatgaaacaa cttttatgga tggcgaaagt tttgatttaa
    12001 aaaatcttcc atggttcaaa aatctttcta tcgttgaaat cccctatgtt agagaagtag
    12061 aaaggtatgg aggaactgac ttgatggctc aaactgaaag aatattttgt atgtcttcaa
    12121 tcattgtgag tcatcttata aagcgcccac tattactaag tcagaaaatt gtaattttat
    12181 atcgtactgt tgagttagta gtagaaaata ttttaactag tcaaaatgat aaaattcgat
    12241 attattcaat gtccagtaga ttttggaaat ctctagagag agtagaaagt atagatatag
    12301 agacttcgga aaaaatctat caaattagtc acaatctaaa tttattgagc ttattgtcag
    12361 aatttataag tggcttaaaa gcgatttatc ttgaagtatt gaagcaggat caagagtacg
    12421 caatgagtgt tgtcatgtca catttgcata tgttcgcgaa tagattagga gtatcaattg
    12481 atacggaact gtcttgttat aattatttta gagaaaagga gagatatgat gctgttggat
    12541 gataggtatt ttgtaaacaa aaaaaagaat tataactacc tagttaagca gaatcttcgt
    12601 gatgcacaga attatagtgg ttggttgatg aattttgccc cgactggaaa tttaaattta
    12661 aaatttgaga cagaaattac aaacgtgacg agaagcaaga actattggga tattgatact
    12721 tcagcgatta aatttataga tgatttgagt tatactttgg aaaataggtg ttcaactcca
    12781 gtggctaatt tagatagcga atggagcgaa gaagaagtac tgtttctttt aaataaatca
    12841 attggtaatg ggaaaagggg aaaagtttac caagatagct atattccact acgaaactat
    12901 ccttcaggtg gtgcacaata tcctattaaa ctataccttg ttatgaataa aaatattgat
    12961 ttttttaagt ctagtaggtc ctatgaaatc catccggatt taggaattat aacagaggtt
    13021 gaagttgagg actgtaaatt cgaagatatt tttgcgattt ctcactttaa taaagagacc
    13081 agtgaagaaa ctaaaaaatt atcatttgcg attatcatga atatgaattt gaaacatagt
    13141 tttaaaaaat ataaatatta ctctaagcaa ctggctatgc ttgaagctgg tcatattgct
    13201 caaaatttac agctagtttc caccggcctg gggaaaaaat cgctccctaa tggtgggata
    13261 ctgtcggatt tcagtaagaa aattataggt ctggaaggaa gtaaagatga tattgttgtg
    13321 tatggggtga cgttttagat gaaacaaatt tatattaatc cgttttatga tgtaatcatt
    13381 aattgtgaca aagagatcaa tataattaat aaagtatcaa atagaatact ttttaaagga
    13441 atctctgaaa aaagcaatgg ggttgaacag caagaaaaag tattactcaa gaagatagag
    13501 aagctttttt caaaacattt gatggtcaca aaacaagagt atcagttttt actagattta
    13561 aaaaaatatg ttgacgatat tgacaattct ataaaagagg atgttaaatt ttcccattta
    13621 tttgatgatt ggctgtttag tactcaatta gataaagtag aaattttgga cggagaggtg
    13681 caagtgaagc ggttgctatc aaatgataac gctacgtatc aagaagcaat tcttgaaatt
    13741 aatctagaaa ctgatttgga ctacaacaag ttgttgctta ccttgaaaca ctacaaatat
    13801 gtatatattt gtagtgttgg tgattttacc acggtagggc cgtttcttga acaaagtcat
    13861 ttgaaaatcg aaaatttttt tgagattttt actaaccaag aaattgatga gagcttcatt
    13921 gatagttcac tggaggctgg tgtcaaacag tttgtgaata acttagttta caatatgctt
    13981 gttgaaagaa ttagtaattt tttattagcg cagtcccctt tttacaatag aaagatttat
    14041 attaaatcta acaataggat agaacttgga gaggaattgg ctctggtcta attaaataga
    14101 attatggata tatttgatta cggaaggcag gtgtatcggt tgcttcactc tatacctgag
    14161 ggatcaggac aagagtataa aactagtcag actatttcaa aacttgttga agcaatagga
    14221 ggatatacct tagtgcacaa tggtaaggaa gggctcgttt attctaattg tcacccacaa
    14281 acttacatat ttgaccttgc ttttcgagcg gaaatggatg caatcatact acctaataat
    14341 gatgctttcc atggctgtgg acatgattta cacatgactt ctttaataca attaatggcc
    14401 ttcctaaaga tttttccatc aagtcgaaaa attttatttg tatttcagag ttctgaagaa
    14461 gctgggaatg gggccaaaaa tatggtcaat actttgaatc ataaaggagt tagagtaaat
    14521 aaaattattg gtcttcacaa tgcaccagat attttggtag aagatttagc aataaaaaaa
    14581 aatgaaacct tatctaataa ttttactaat cgtttaacga ttcaatttta tgaagaagaa
    14641 cggtatgatt atcatatgcc aaaaaatcct ttgtcgaatt ggtcagagat ttattcaaaa
    14701 ataactactc tctacaatca tttatctggg gtattattta gaataggtga gtttagatcg
    14761 aatggccaaa ctggaataca ggcggacgaa ctttctttta gcctatcaat tcgttctaat
    14821 gagcttccac ttaaaagttt gtacgaatta tttgatgagt tagtagtaga aatccaagac
    14881 cttaattatg tcaaacactt atttgtagaa aacattaatt atcactggcg gatttataat
    14941 agtccaaaaa tatatgaaat aatcaaaaat aatagacttt ttaatacctt agagattccg
    15001 gatagtttca catcagatga cttttgctat tatgaaggaa ttgcacaaga gattttctat
    15061 ttgtttttag gtagttttga aaatgctgtc gtttcaaaaa cacataccaa aatatttaga
    15121 cctaatctag attttctcaa taattcactc aagttatata aatttttatt ggaggaaatg
    15181 taatgtatat cttttacaga caaaatagaa aatcagttag tgactttatc aactgctttt
    15241 acgaaggtga gactgacgat gtaatcaaac aattgcaaga aacagattac cgaataaatg
    15301 agatttcaaa gcagctaata aataatattg acgattatat atataaaaat gaattaaagt
    15361 atccagatgc aaaagactat ctgacagtaa aaagaaaagt aaagagaaga aaagtattaa
    15421 aacaacagtt tgaaaaaatt gctgaagaaa ttccatttta taatagtctg ttagcgttaa
    15481 agatagaact ggaagaaaag gtgaataaag ctttagagag tgattataaa aaacaagtaa
    15541 ctgaatttcc taagttattc tctgaggaag agttacttct atttagaaat gaacatttaa
    15601 aatataagtt gatgaaacag ggaaatataa gcttaaagaa aaaagacagg atttctttat
    15661 atcattatat ttcgcagtta agtcttaaaa caggtggagt ggggtttgca aatagtatag
    15721 gctgcttcga attgggaaat tctactcatc atatgaagcc aaaacaaaac tatgttgttg
    15781 atatccataa ctatttgtta aacagattat attttaaagt tttaaaggga aatctatcta
    15841 attttgtagg aagttttttg gttaatttca attacgttat tgataggaaa aagagttttg
    15901 tattatttaa agtcttactg gatgatcctg attcaaatat atttcgcggt aaagaaagag
    15961 aagttaaatt agaattgact tcgcctatca agtggttgtt aacgaaagat aaaatctcaa
    16021 tccaaggttt gaatgaatat tttggtaatg atgaaatcat tcaattactt aattatggta
    16081 ttttacgata tgctcatctc agaccccgtg atgactttag ttggattgat aactttgaca
    16141 ttctcgaacc ttctctttta gcaaaattaa ggcaaatagg aaatttattg caggatttga
    16201 attatcaatt ttcatctgta gacttttcgc gtatagtaga attaattaca gatctttgcc
    16261 aaaagtatag agtagatacg ttaggctctc cactccttac tattgacact tataaagaca
    16321 gccttgactt gtctaatcaa caagtaaaat ttttaaagaa ttttataagt aaaataagga
    16381 gtctaagtga gttttattca atttttgacg cctctaaaag ggttgaagaa ttggcttata
    16441 attttatgat ttatcattac ccggaaggga aatcttttaa aaattttatg gatttagacg
    16501 aattttttaa agaattggcc gaattcgttt ttgaaaaaat caatttaggc gctctacgtt
    16561 cgggattttt tgagtttgct gattatcctc taatagcttt cattataaat aagatttgtt
    16621 cgtctaactc tcaagacttt cttttttcag aagacgattt agaagagata ttaaaaaaat
    16681 taaagttaaa cagttacaat tcagatcact cctacgcatt ctttgttcag actggtaaag
    16741 agggtgtgta tttgaaccat gtctataagg ggctaggaat ctttaataat cgatatcgag
    16801 ataacttttc tgctaatgat tttgaacaga attataattt tggaagaatt tttgacaccc
    16861 cttattactt cggttttaat gcaaataaaa ggcctgaacg tccaagcctt gatatgtttg
    16921 gactatctga gtatcccaaa gaaagtgaat tggattaccg agatatcatg ataacggtag
    16981 acagttctaa aagatgtctg aggtttttag ataatattgg taaagaattt tatttttctt
    17041 ttttgggcaa catgacacca atagtatttc ctaaaacatt ggctatgttt aatagtctgt
    17101 cattaacggg tggaatgtat tttgatttgt ctgatttggt tctaagaaag aaatatgcag
    17161 acaataagga tttaaatgtt tttatctctc cacaaattta ttttttggat aaagaaatta
    17221 ttatatctag gagtaaaact ttagttcgaa cgaccttgtt gaaaaagatt tttaatgata
    17281 gtcaaaataa tgctcagatt ttacttggta taaagaaaat ttatcccaac tcatcgttgt
    17341 ttgtcagaga attttttgtt gacagtgatt tcaaaagcaa aataaaaaaa ccgctttttg
    17401 tgaacctcaa cagctctata ggattggaaa actttataga ttacgtggga aaggttgatt
    17461 gggtaacact tgaaactcct caacctgaat ttagccaaga ccatttaaca gaatttattg
    17521 ttgaaagtaa gaatacaatc ccagataagt agctatttat tctgacaaaa gtaggactat
    17581 ataactggga accatagtcc catatattga tagtaaaaaa ggagataaga atgtttacat
    17641 taactaatat tgaaaagaca ttcggtggaa cgaacaaaat tttacaagga atctctcttt
    17701 caattgaaga tggtgaacga attgctttgc ttggaagtaa tggtgctggt aagacaactt
    17761 tgctgaaaat tatttctgga caacttaaac agaataaagg aacaattaac tcgaaattag
    17821 attttcagag tgaaattggt atgatgccac aaggggatat tttgattgat gatttaaagg
    17881 tgaaagaaat tgtgaatttg aaggcttata tgaaccgcct aagggagaaa aacattgata
    17941 gtcttttaga gaaagttgat ttaaaagatc agaaagacaa atttgtgtct agtctttctg
    18001 gaggacaaaa aagacgtctc tcgttattat tggcaatttt aaataatcca aaattaattt
    18061 ttcttgatga accaactact gggatggatt tagagtcagt tgataaattc tgggagctat
    18121 taaagaagca agatgtcacc tcggtaatag taacccatga ttttaatcaa attgataagt
    18181 tctttacccg agtcttaatt ttaaaaaatg ggaagatctt tgctgatgag aaagttgagg
    18241 tcattcatca acagggttta acaatcgaaa agttttatag aactattaat gataaggaga
    18301 tttaatatgc caaaatttat tcaattaaaa caggttatac gtaataaacg ttttctgctg
    18361 ttcactattt ttattccaat agtttggtat gcttttttgc ataatgttca aagcatttca
    18421 tctaatatta ttttagggat tgcagttttt attggtatta ttggcaatag cttggcgaca
    18481 tttagtaaaa ggatttcatc taatattgat ttctatgcct ttgaatcacg atttactcat
    18541 tatagtatca agaactatct ctttgaccag acatttattc aaattgtttt aaatactctg
    18601 atcttctttg caatcctttt ttccgctgta gcattcttta aatttcctat agcaagtata
    18661 gtttttgttc aatttttact cttaatgttg atgggaatat attttagtat cattggcttt
    18721 gttatgggag ttcgattaga taccaaaatt atcgatacgg ttagctttcc gattattatt
    18781 gtggcatctt tgacgattat tccattcaaa aacctaggtg cctcaggaaa ttttgtagat
    18841 atattgagta aaatccaaat gatatttccc ggctactact atagtagtat tatcaacgct
    18901 ctaatgaagg ataatcctgt taaaacaaac gatatccttt tgtttttagt aacatttttt
    18961 ctcaatatca ttgtgctata ttttttgatt ccacatggtc aactgaaaca aagagttgct
    19021 aaataaaata ctatatgtac taatttaact atagaattta atttttttca aattgagaaa
    19081 gcttatgcgg tgacaacggt agttggcctg actttaatga tggtcggagt aggttttgct
    19141 agtgcagata gtaataccga caaacataga gaaagagtag ctgatcgttt aaacataatg
    19201 gaacatccat tcgactctat cctcctagtt agtttagaaa atttatctta ttcgcgaata
    19261 tgataaattt caaaaaaata tcatatttgc gaatatcaag aaatcggaaa ttatagtgat
    19321 ataattcata tgtaagcgat ttaattaact gtttacgcca tatcgcttta aaagttctgc
    19381 tagctatatc tttaatcgta gtatgaaatt taaacaagga ggaaagtcat catgacaaaa
    19441 agacaatcac gtcttgttaa agcgggatgg gtatgtattg gctggggctt cgtttgctgg
    19501 tgctaattag taaacggaaa cctagcacag agtttagtgg atagccgtat agctatccac
    19561 tttttagatg aggagaaaaa aatagtatga agtattatca cactatgcag gatctcgcat
    19621 cagattgtgg aatagcggtt gtgaaatcaa ttttattgac atatgggcgg tacgatgaaa
    19681 ctctattaac agatagactt caacatctta atattgacca aggattatca ttacttgata
    19741 ttgaagaatt gctttcaatc tttggaatat acggtagtaa ttatcaggtt aatgaattta
    19801 gtaatcttaa ttttaaaact ccttgtattc tagtgacgag aagggatggg ataaaccatt
    19861 acattttagg ctacggaaaa caaaacgata agttggttgt ttctaatcct gctgagaaga
    19921 ctattagcta ccagtcgttt gaagaagtac gagatatttt taatggtttt gcctatattg
    19981 ttgaaagcga tgattctaag gtcgtgttga aagagacaag tgcaactagt gaaaatgata
    20041 ataactcctt gagttttaaa gaaaggttga gcctgttttt ttatgacgag cttactttgg
    20101 ctaattccct tgtttattat tttttctatt caatatttaa ttgtttttca aggccccgtt
    20161 gtaaaatgag gtgcaacaaa aaaagacaag cttatctgat atactaaagt tgcgaaacaa
    20221 agtataagga aagagataag catgtccacc accaattgta ccacaaaaca accctattgc
    20281 cacctctcag aggtagaacg aggaaaaatt gaggccttcc tatcagaagg gttgaaacca
    20341 gctgagattg ctagacgctt gggaagaagt cgctccacca tttcacgtga aatcaagcgt
    20401 gggacgacaa aacaagtcaa gcaggtaaat ggtaaaaaga tctactttga ctactacttc
    20461 gctgacctag ctcaaaggcg ttacgttgaa gggcaacgag gaattgacta cctcaaactc
    20521 gaaaaggtat ctgagcactt tctaaaggcc tttgaagaag ccatgaaggc ctctcccaga
    20581 gttcatagtg tagagagctt cgtttatgct tataaagagg aacacccaag tgaaaccgtt
    20641 ccaagtacca aaacccttta caactatagt catcaaggct tgctagctat taaggccatt
    20701 gatttcccta aagctgtacg gcttcgtaaa aagactaaga agcgctcttc aacgcagaaa
    20761 caccttggtg tctccattga agagaggcca gaaaccatca atgaccgctc tgtatttgga
    20821 cattgggaaa ttgactccgt attagggact cagaaagctg gagaaccttc catcttgact
    20881 ttggttgagc ggaaaacccg ctacgctatt acagcttacc tggctggtaa aaaagctgag
    20941 gacgttaacg aggcggtagc tgagcttatt cagcagtatc ccatcaaatc cattacagct
    21001 gataatggtt ctgagttcgc ttccttgaat gaattagaag gtgttcaggt ttactatgcc
    21061 catgcttact cctcatacga acgtgggaca aatgagaact tcaacggctt acttagagag
    21121 ttcgttccta aaggtaagtc gctcaagact ctcacagctg aggatttagc taaggcgacc
    21181 ttagctatca atcaaagacc aagaaaacta ctcaactatc aaacggcgaa aaccctgttt
    21241 gggctagccc aaacagccta gcccctcttc aacttggtat cagataacaa ctgttgcact
    21301 taacttgaca attcgggttt tcaaaatgta gaggtactct agagtaacat aatagaaagg
    21361 ttagtaggta tgaatattag tacgaatcac tacaaactac gcaaagtaaa gaaacgttgg
    21421 gtcacttttg tcgtaacaac tatggctggt ctaacattaa tgacagctgg agcaagctcc
    21481 gccagtgcag atagctcaac tctggattct caagtcaatc aaacgtcaac tcttgtccaa
    21541 ccgacaagcg atggaacttc agtggttgct cctagccaag agaaggtgcc atccaatccg
    21601 acagaggtga aggatactga taatcaatca gaaaatcagt ctcaaccaac tcaagcggcc
    21661 tctttaacca ctcaagaaga tgacaaggag cctactagcc aaaacaatca agcaccggct
    21721 gactctccaa aacaggttaa ggaaccaact tcagttgccc cagcttcaga tggcgcagtc
    21781 gtccagcaag aacctcaaac tcaaaaacag gaagaaaaaa caacaggggg taaaaatgag
    21841 gtaacatcaa cggatgctgt ggtgacaact gccccaaccc ttacctccga tgaccagcgg
    21901 gcagacatta ataaaatcct tgatggacgt ttatcaggta tttctactct tgatgcggcg
    21961 gctctgacct atgagtttga aaaggctcgc ttgaaaggag ctactgatgc cactatttta
    22021 gctaaaatcc aagaagcagg gcgtgtgata cctaacaatc tgacctatct cagtgatttc
    22081 tacgataatc agacgggaac aagtggaact gcctttcgag ataaggccag taataaggtt
    22141 atcattgcct atacgggaac taataatgat ggtaatgaac ttcaagatgc cctaggagct
    22201 gacctgatgg gaatcggtct agctagaggt cagcactatc aacctgccta tgatttttat
    22261 gataaaattg ctagccaata tggtgctgaa attattgtga ttaccggaca ctccctaggt
    22321 gggaatgtgg ctcaacgcgt tgccttgaag aaaaatgctg caaccacggt tgtctataat
    22381 tcggcccccc tctacattcc agcccttgcc tcagtcggta acaagattta tgagtctctg
    22441 aggaaaaatt ttgatctccc atcgaataag gcagaggcca agaagacgat cgcagctatc
    22501 aggagtgata tgaagacttt cacaggccat gttatccgta tcacaacgac caaggattgg
    22561 ctcaacaatg ctatgcgttg gttgggagcc gtttacctcg gcaaggaata tgtgattcct
    22621 gattcaggca atcacgattt gcagcccatt gccgaaaatg ctaagcaagt agctagtgtg
    22681 aagcagtgga caaccattta acttactaaa taaaaaaact aaccttctag tttttaaatg
    22741 aaccgctccc tgtcaagtag acagtcaaat aatataagca acctgattcc tgaattctaa
    22801 aggagtcagg ttatttagtt tttcttgata acgttgggtg ttataaaagc tgatatagtc
    22861 gtcaatagct gtaaccaatt cctcaaaggt cttgtagtgt tggagatggt aagactctgt
    22921 cttgaaatgg ccaaagaaac tctcaattgg ggcgttatca atacatttgc caacccgtga
    22981 catggatagg gtgagcccag cttgggtggt gaaatcacgg ttgagaatag tctcttcata
    23041 atatttatcc ccagattttg tacaggcatg gcgaacacga cgactgacag agcgaatgcc
    23101 tagaatgtgc atgagtcggc gaatccgctt cttgttatac tgggtgccta gttgccggtt
    23161 gacaaaggcg gtcatgcggc gatagccgag gataccattg tagcgatgat gaaaagattt
    23221 tatggttgcc atcagctctt tgttcactct ttcagaaggc gtctctggat gctttagcca
    23281 tttataatag cctgaacgag agactttcag aattctgcac aaggtttgaa tagggaag
//
