LOCUS       NZ_LR822015.1          16283 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  NZ_LR822015.1 Streptococcus thermophilus isolate STH_CIRM_65
            chromosome STHERMO, complete sequence.
ACCESSION   NZ_LR822015
VERSION     NZ_LR822015.1
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 6.1.1
            Run date     :: 2024-03-14 15:18:11
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 1475267
            Orig. end    :: 1491550
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..16283
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[1480267:1486550]"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193)"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      5001..11283
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193)"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
     cand_cluster    1..16283
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193)"
                     /kind="single"
                     /product="RiPP-like"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..16283
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="RiPP-like"
                     /region_number="5"
                     /rules="(strepbact or Antimicrobial14 or Bacteriocin_IId or
                     BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or
                     Lactococcin or Antimicrobial17 or Lactococcin_972 or
                     Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or
                     TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or
                     TIGR03975 or DUF692 or TIGR01193)"
                     /tool="antismash"
     CDS             complement(282..1211)
                     /locus_tag="ctg1_1532"
                     /transl_table=11
                     /translation="MKKRTLTLWMMSSALLLNLSVGTALADEVVETGADNSPKVEATES
                     TPVEQPSDSQEQSLPEDKEAPAATESVTLAESEEETAKNDIPAVSREEYDANVADLPKI
                     SLDDVRNAFTEDGQAHTIYFGRGTCYYCRQFSPELKVLNQLMDGRLEYYDIDREDFDRN
                     YVFGEIGIPGTPTLLYLENGQLLSGWVGGGPAQTVYDHLASSSPRFMTLNQEQTTISEP
                     QTKTVRPTRVTEESTKEKSLPTVQPQPMSTVQKELNAQTGQMAPMTDKVADTKEFPKTN
                     DGEQSLVSFVGALAILASLMLALRYYIK"
     CDS             1405..2091
                     /gene_functions="other (smcogs) SMCOG1164:transposase
                     IS3/IS911 family protein (Score: 25.1; E-value: 2.3e-07)"
                     /gene_kind="other"
                     /locus_tag="ctg1_1533"
                     /transl_table=11
                     /translation="MSKRSPKSVSEKLEIVLLHLEEGKSLSWLTRNQGISKDTLSNWVR
                     KYKEAGVDGLEESRQWKKYSKELKEQAVSDYLNGLGSLKDLTKKYGISDPYVLRSWIKS
                     YTSGKELKATSKGMRRMKQGRKTTFEERIEIVNFTLAHEKDYQGAVEKYGVSYQQIYSW
                     VRKFEKDGSNGLLDRRGKGLTSKPNLTPEEELRLKIKQQEERIKYLEMENGLLKKLEEI
                     KRRNRR"
     PFAM_domain     1435..1581
                     /aSDomain="HTH_28"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF13518.8"
                     /description="Helix-turn-helix domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_1533_0132"
                     /evalue="2.30E-09"
                     /label="ctg1_1533"
                     /locus_tag="ctg1_1533"
                     /protein_end="59"
                     /protein_start="10"
                     /score="37.3"
                     /tool="antismash"
                     /translation="EKLEIVLLHLEEGKSLSWLTRNQGISKDTLSNWVRKYKEAGVDGL
                     EESR"
     PFAM_domain     1795..1950
                     /aSDomain="HTH_28"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF13518.8"
                     /description="Helix-turn-helix domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_1533_0133"
                     /evalue="2.20E-11"
                     /label="ctg1_1533"
                     /locus_tag="ctg1_1533"
                     /protein_end="182"
                     /protein_start="130"
                     /score="43.8"
                     /tool="antismash"
                     /translation="ERIEIVNFTLAHEKDYQGAVEKYGVSYQQIYSWVRKFEKDGSNGL
                     LDRRGKG"
     CDS             2106..2975
                     /gene_functions="other (smcogs) SMCOG1026:transposase
                     (Score: 247.8; E-value: 1.9e-75)"
                     /gene_kind="other"
                     /locus_tag="ctg1_1534"
                     /transl_table=11
                     /translation="LETFQAIKEYADEYEEVSISHLCHILKVSRSGYYKWLQHQETTSE
                     QENLGLMDIIKKLHSQHNGILGYRRMTLFVNRKLETNYNKKRIRRLMHILGLRSIIRRA
                     KGYCTKTSFVNVEDNILNRNFTATAPNQKWCTDVTFLKYGFSCKAYLSAIKDLYDGSIV
                     AYVVGQFNDNELVLETLRKAQKANPNATPLIHSDRGSQYTSKDYYRLTTQYQMTRSMSR
                     VGKCIDNAPIESFFGHFKTECYDLKKYKTFEELVSDIDAYIYFYNHQRFQERNNGLAPL
                     EMRNKAVA"
     PFAM_domain     2256..2417
                     /aSDomain="HTH_21"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF13276.8"
                     /description="HTH-like domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_1534_0134"
                     /evalue="6.90E-13"
                     /label="ctg1_1534"
                     /locus_tag="ctg1_1534"
                     /protein_end="104"
                     /protein_start="50"
                     /score="48.6"
                     /tool="antismash"
                     /translation="LMDIIKKLHSQHNGILGYRRMTLFVNRKLETNYNKKRIRRLMHIL
                     GLRSIIRRA"
     PFAM_domain     2487..2783
                     /aSDomain="rve"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00665.28"
                     /description="Integrase core domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_1534_0135"
                     /evalue="4.50E-17"
                     /label="ctg1_1534"
                     /locus_tag="ctg1_1534"
                     /protein_end="226"
                     /protein_start="127"
                     /score="62.3"
                     /tool="antismash"
                     /translation="TAPNQKWCTDVTFLKYGFSCKAYLSAIKDLYDGSIVAYVVGQFND
                     NELVLETLRKAQKANPNATPLIHSDRGSQYTSKDYYRLTTQYQMTRSMSRVGKC"
     PFAM_domain     2802..2963
                     /aSDomain="rve_2"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF13333.8"
                     /description="Integrase core domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_1534_0136"
                     /evalue="6.10E-14"
                     /label="ctg1_1534"
                     /locus_tag="ctg1_1534"
                     /protein_end="286"
                     /protein_start="232"
                     /score="52.0"
                     /tool="antismash"
                     /translation="ESFFGHFKTECYDLKKYKTFEELVSDIDAYIYFYNHQRFQERNNG
                     LAPLEMRNK"
     CDS             complement(3222..3362)
                     /locus_tag="ctg1_1535"
                     /transl_table=11
                     /translation="MATQTIENLTPLTSKHLLVLKEVDVVGEAQVERLFKELSEERLEV
                     M"
     CDS             complement(3613..4014)
                     /locus_tag="ctg1_1536"
                     /transl_table=11
                     /translation="MKLKNISSSVLRSFRTITAALAVFLISISLSLYKSKISPGTWLAV
                     GALAFVVIFVNGLLYRMLKKRPDSVNLLTIRQSFIVFPVITFLVLSVEFYTLLTFSDTT
                     DRIVLAVLMLLLILCDFLSYLQVKKYFKQ"
     CDS             complement(4344..4511)
                     /locus_tag="ctg1_1537"
                     /transl_table=11
                     /translation="MFKNSKPYLLATILIVMGLANLFRSLDAVHHTINLLGLTVLLYSL
                     LFKKWVQFQK"
     CDS             complement(4869..4994)
                     /locus_tag="ctg1_1538"
                     /transl_table=11
                     /translation="MFDLKSYILGMVSMAVMSFLDKPIMSFLEKHKATNSVKKKS"
     CDS             complement(5001..5231)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: Bacteriocin_IIc"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg1_1539"
                     /sec_met_domain="Bacteriocin_IIc (E-value: 3.1e-17,
                     bitscore: 59.5, seeds: 35, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MATQTIENFNTLDLETLASVEGGGCSWGGFAKQGVATGVGNGLRL
                     GIKTRTWQGAVAGAAGGAIVGGVGYGATCWW"
     PFAM_domain     complement(5037..5213)
                     /aSDomain="Bacteriocin_IIc"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF10439.11"
                     /description="Bacteriocin class II with double-glycine
                     leader peptide"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_1539_0137"
                     /evalue="1.30E-13"
                     /label="ctg1_1539"
                     /locus_tag="ctg1_1539"
                     /protein_end="65"
                     /protein_start="6"
                     /score="50.8"
                     /tool="antismash"
                     /translation="ENFNTLDLETLASVEGGGCSWGGFAKQGVATGVGNGLRLGIKTRT
                     WQGAVAGAAGGAIV"
     CDS             5481..6212
                     /locus_tag="ctg1_1540"
                     /transl_table=11
                     /translation="LKIYLLEDNSIQMGRLEEAVAHELKSFGKDLSCVQSFDKPDQLLS
                     AITSNTSDQIFFLDIEIKGEDKKGLDIAKIVRQNNPYAIIAFVTTHIEFMPQAFGVTAY
                     KYINKTLDEASFRKEIGETIAQVFPINATTTDEFFLYKTESQLINLPMDQILYLSTSDI
                     KHHVHLQTIHTLMDIRANLADFKKIHKKLYPCHRSYIVNTDMIISVNKTNYEATLINGQ
                     VLPVSRMKIGKIAQIVEERGR"
     PFAM_domain     5529..5837
                     /aSDomain="Response_reg"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00072.26"
                     /description="Response regulator receiver domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_1540_0138"
                     /evalue="3.80E-07"
                     /label="ctg1_1540"
                     /locus_tag="ctg1_1540"
                     /protein_end="119"
                     /protein_start="16"
                     /score="30.3"
                     /tool="antismash"
                     /translation="EEAVAHELKSFGKDLSCVQSFDKPDQLLSAITSNTSDQIFFLDIE
                     IKGEDKKGLDIAKIVRQNNPYAIIAFVTTHIEFMPQAFGVTAYKYINKTLDEASFRKE"
     PFAM_domain     5916..6191
                     /aSDomain="LytTR"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF04397.17"
                     /description="LytTr DNA-binding domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_1540_0139"
                     /evalue="2.20E-14"
                     /label="ctg1_1540"
                     /locus_tag="ctg1_1540"
                     /protein_end="237"
                     /protein_start="145"
                     /score="53.6"
                     /tool="antismash"
                     /translation="QLINLPMDQILYLSTSDIKHHVHLQTIHTLMDIRANLADFKKIHK
                     KLYPCHRSYIVNTDMIISVNKTNYEATLINGQVLPVSRMKIGKIAQI"
     CDS             6209..7552
                     /locus_tag="ctg1_1541"
                     /transl_table=11
                     /translation="MMLTTLWLLFLTLLSAGLEIILFLYLMGQKIRLRYFFLLLIFNLA
                     FNFIYNHSSWFIIKFWGEDIYYLLLSFLLSTKTKKPLKIKIFNGLFPDILNNLSLRLIT
                     FFIFPFFNISITDYKSSLLISIPSSIAPLCLSFLFIKLFKESFTILQKQKSNSPIQHII
                     IVANFFMFGYTLLLQSLMYLENTTHSSTLELRKLCVVISLVLFFIMIVFLERNIREMIQ
                     GQLDFQKNLQLENLYTYNKHIECLYNSVRSFRHDYSNLLVTLRLGIDKDDMDIVKEVYD
                     SVLQESDKRLNTRNFDLARLVNIQDNTLKSLLSAKVLQAEEEGIEAQISIPEPIHLIGM
                     EILDFIIVTSIFLDNAIEGAIQTQNHKITISFWEDHRSQLLSISNTISEEQTETKTIFE
                     RGVSNKGRERGIGLANVTEILDNYINVNLETQSNNFSFTQQLTITKKA"
     PFAM_domain     7226..7537
                     /aSDomain="HATPase_c_5"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF14501.8"
                     /description="GHKL domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_1541_0140"
                     /evalue="7.60E-19"
                     /label="ctg1_1541"
                     /locus_tag="ctg1_1541"
                     /protein_end="443"
                     /protein_start="339"
                     /score="67.6"
                     /tool="antismash"
                     /translation="MEILDFIIVTSIFLDNAIEGAIQTQNHKITISFWEDHRSQLLSIS
                     NTISEEQTETKTIFERGVSNKGRERGIGLANVTEILDNYINVNLETQSNNFSFTQQLTI
                     "
     CDS             complement(7570..7731)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: Bacteriocin_IIc"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg1_1542"
                     /sec_met_domain="Bacteriocin_IIc (E-value: 3e-07, bitscore:
                     27.5, seeds: 35, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MANNTINNFETLDNHALEQVVGGSGWMDYINGFLKGFGGQRTLPT
                     KDYNIPQV"
     PFAM_domain     complement(7642..7731)
                     /aSDomain="ComC"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF03047.16"
                     /description="COMC family"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_1542_0141"
                     /evalue="5.10E-16"
                     /label="ctg1_1542"
                     /locus_tag="ctg1_1542"
                     /protein_end="30"
                     /protein_start="0"
                     /score="57.9"
                     /tool="antismash"
                     /translation="MANNTINNFETLDNHALEQVVGGSGWMDYI"
     aSDomain        complement(7663..7707)
                     /aSDomain="TIGR01847"
                     /aSTool="tigrfam"
                     /description="bacteriocin_sig: bacteriocin-type signal
                     sequence"
                     /detection="hmmscan"
                     /domain_id="TIGRFam_ctg1_1542_0024"
                     /evalue="5.80E-03"
                     /identifier="TIGR01847"
                     /label="ctg1_1542"
                     /locus_tag="ctg1_1542"
                     /protein_end="23"
                     /protein_start="8"
                     /score="15.2"
                     /tool="antismash"
                     /translation="FETLDNHALEQVVGG"
     CDS             complement(7746..8651)
                     /locus_tag="ctg1_1543"
                     /transl_table=11
                     /translation="LGVAKTNTEVNNQAAIASNTGSAIDNQISQLQTQVSEYEALSQAI
                     TNHETTLPEGNPHQATLNAYNSQYATTPDASVTDQYLSQVNTNISSLNASIGNLEIQKA
                     GTGTVVTYDNSDSTKKEALKNQFLQNAGQQLSSVETQITDTESKINQADVLLTNTLIQS
                     PEDGILHLSQADKKATMAATGTELAQLYPDMTQTQEVAITYYVNSDYVPKLQKGQSVRL
                     TLDKVGNHGTTIIGKLESIDNSATETERGNVFRVTARASISEKEAQNLRYGLESRVTSV
                     IDQKTYFNYFKDKLLNLQDQ"
     PFAM_domain     complement(7833..8171)
                     /aSDomain="HlyD_3"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF13437.8"
                     /description="HlyD family secretion protein"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_1543_0142"
                     /evalue="9.10E-14"
                     /label="ctg1_1543"
                     /locus_tag="ctg1_1543"
                     /protein_end="273"
                     /protein_start="160"
                     /score="52.1"
                     /tool="antismash"
                     /translation="IQSPEDGILHLSQADKKATMAATGTELAQLYPDMTQTQEVAITYY
                     VNSDYVPKLQKGQSVRLTLDKVGNHGTTIIGKLESIDNSATETERGNVFRVTARASISE
                     KEAQNLRYG"
     CDS             complement(8779..9114)
                     /locus_tag="ctg1_1544"
                     /transl_table=11
                     /translation="MNPQLFKSTEFYHRRYHNMSTVLITPLILLVIFLFLFAFFAKKEV
                     TVTSRGSIEPTKVIAVIQSTSDNTIIDNQLVANKVVKKGDTLVQYSETMEASQKEGLQK
                     QLELLKR"
     CDS             complement(9130..11283)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: TIGR01193"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_C39"
                     /gene_functions="transport (smcogs) SMCOG1288:ABC
                     transporter related protein (Score: 309.7; E-value:
                     6.7e-94)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg1_1545"
                     /sec_met_domain="TIGR01193 (E-value: 0.0, bitscore: 1102.7,
                     seeds: 5, tool: rule-based-clusters)"
                     /sec_met_domain="Peptidase_C39 (E-value: 8.6e-43, bitscore:
                     142.2, seeds: 36, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MFRFRRTFVPQIDMRNCGVAALASVAKYYGSDYSLAHLRELAKTN
                     KEGTTALGLVEAAKKIGFETRAIKAEMSLFEMEDVPYPFIAHVNKDGKLQHYYVIYKST
                     KDYLIIGDPDPSVKVTKMTKERFEKEWTGVTLFMGPEPSYKPHKDKKNGLWDFLPLIFK
                     QRSLIANIVFASLLVTLINILGSYYLQGILDEYVPNQMKSTLGIISIGLVVTYVLQQMM
                     TFARDYLLTILSQRLTIDVILSYIRHIFELPMSFFATRRTGEVISRFSDANSIIDALAS
                     TILSLFLDFSIVIIVGGVLLIQNSNLFKLVLCSVPIYTLIVFAFMKPFERMNHDVMQSN
                     AMVNSAIIEDINGIETIKSLTSEEVCYQKIDGEFVDYLDNSFRLSKLSILQTSLKQGAQ
                     LILNVLILWTGAQLVMGNTISIGQLITFNMLLSYFTNPLENIINLQTKLQSAKVANTRL
                     NEVYLIESEFGQSDDTYQEGIADGDITVTDLSYKYGFGRDTLTDVSLTIRQGEKISFVG
                     VSGSGKTTLAKMLVNFYQPYKGHIDFNGQNISRIDKKTLRQHINYLPQQSYIFSGSVLE
                     NLTLGAARGITQADILKACEIAEIRQDIENMPMGFQTELSDGAGLSGGQKQRIALARAL
                     LTKSPVLILDEATSGLDVLTEKQVIDNLLALKDKTIIFVAHRLSIAERTDRIVVIDQGR
                     VVETGSHQDLMSYPGFYYQLFRK"
     aSDomain        complement(9136..11253)
                     /aSDomain="TIGR01193"
                     /aSTool="tigrfam"
                     /description="bacteriocin_ABC: ABC-type bacteriocin
                     transporter"
                     /detection="hmmscan"
                     /domain_id="TIGRFam_ctg1_1545_0025"
                     /evalue="0.00E+00"
                     /identifier="TIGR01193"
                     /label="ctg1_1545"
                     /locus_tag="ctg1_1545"
                     /protein_end="716"
                     /protein_start="10"
                     /score="1102.7"
                     /tool="antismash"
                     /translation="QIDMRNCGVAALASVAKYYGSDYSLAHLRELAKTNKEGTTALGLV
                     EAAKKIGFETRAIKAEMSLFEMEDVPYPFIAHVNKDGKLQHYYVIYKSTKDYLIIGDPD
                     PSVKVTKMTKERFEKEWTGVTLFMGPEPSYKPHKDKKNGLWDFLPLIFKQRSLIANIVF
                     ASLLVTLINILGSYYLQGILDEYVPNQMKSTLGIISIGLVVTYVLQQMMTFARDYLLTI
                     LSQRLTIDVILSYIRHIFELPMSFFATRRTGEVISRFSDANSIIDALASTILSLFLDFS
                     IVIIVGGVLLIQNSNLFKLVLCSVPIYTLIVFAFMKPFERMNHDVMQSNAMVNSAIIED
                     INGIETIKSLTSEEVCYQKIDGEFVDYLDNSFRLSKLSILQTSLKQGAQLILNVLILWT
                     GAQLVMGNTISIGQLITFNMLLSYFTNPLENIINLQTKLQSAKVANTRLNEVYLIESEF
                     GQSDDTYQEGIADGDITVTDLSYKYGFGRDTLTDVSLTIRQGEKISFVGVSGSGKTTLA
                     KMLVNFYQPYKGHIDFNGQNISRIDKKTLRQHINYLPQQSYIFSGSVLENLTLGAARGI
                     TQADILKACEIAEIRQDIENMPMGFQTELSDGAGLSGGQKQRIALARALLTKSPVLILD
                     EATSGLDVLTEKQVIDNLLALKDKTIIFVAHRLSIAERTDRIVVIDQGRVVETGSHQDL
                     MSYPGFYYQLFR"
     PFAM_domain     complement(9337..9786)
                     /aSDomain="ABC_tran"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00005.29"
                     /description="ABC transporter"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_1545_0145"
                     /evalue="7.40E-33"
                     /label="ctg1_1545"
                     /locus_tag="ctg1_1545"
                     /protein_end="649"
                     /protein_start="499"
                     /score="114.1"
                     /tool="antismash"
                     /translation="LTDVSLTIRQGEKISFVGVSGSGKTTLAKMLVNFYQPYKGHIDFN
                     GQNISRIDKKTLRQHINYLPQQSYIFSGSVLENLTLGAARGITQADILKACEIAEIRQD
                     IENMPMGFQTELSDGAGLSGGQKQRIALARALLTKSPVLILDEATS"
     PFAM_domain     complement(9970..10776)
                     /aSDomain="ABC_membrane"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00664.25"
                     /description="ABC transporter transmembrane region"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_1545_0144"
                     /evalue="8.50E-56"
                     /label="ctg1_1545"
                     /locus_tag="ctg1_1545"
                     /protein_end="438"
                     /protein_start="169"
                     /score="189.7"
                     /tool="antismash"
                     /translation="NIVFASLLVTLINILGSYYLQGILDEYVPNQMKSTLGIISIGLVV
                     TYVLQQMMTFARDYLLTILSQRLTIDVILSYIRHIFELPMSFFATRRTGEVISRFSDAN
                     SIIDALASTILSLFLDFSIVIIVGGVLLIQNSNLFKLVLCSVPIYTLIVFAFMKPFERM
                     NHDVMQSNAMVNSAIIEDINGIETIKSLTSEEVCYQKIDGEFVDYLDNSFRLSKLSILQ
                     TSLKQGAQLILNVLILWTGAQLVMGNTISIGQLITFNMLLSYFTNPL"
     PFAM_domain     complement(10858..11265)
                     /aSDomain="Peptidase_C39"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF03412.17"
                     /description="Peptidase C39 family"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_1545_0143"
                     /evalue="8.80E-42"
                     /label="ctg1_1545"
                     /locus_tag="ctg1_1545"
                     /protein_end="142"
                     /protein_start="6"
                     /score="142.2"
                     /tool="antismash"
                     /translation="TFVPQIDMRNCGVAALASVAKYYGSDYSLAHLRELAKTNKEGTTA
                     LGLVEAAKKIGFETRAIKAEMSLFEMEDVPYPFIAHVNKDGKLQHYYVIYKSTKDYLII
                     GDPDPSVKVTKMTKERFEKEWTGVTLFMGPEP"
     CDS             complement(12297..14042)
                     /gene_functions="resistance (resist) ABC_efflux (Score:
                     283.7; E-value: 1.8e-86)"
                     /gene_functions="transport (smcogs) SMCOG1288:ABC
                     transporter related protein (Score: 312.7; E-value:
                     8.1e-95)"
                     /gene_kind="transport"
                     /locus_tag="ctg1_1546"
                     /transl_table=11
                     /translation="MPNQNQWSVFKRLLTYLKPYKFLTFLALTFLLSTTVIKSIIPLVA
                     SYFIDHYLHDMNQAASMILIGYYGLYLLQTLVQYLGNLFFARVSYSIVRDIRRDAFANM
                     EKLGMSYFDKTPAGSIVSRLTNDTETISEMFSGILSSFISAIFIFVTTLYTMMILDIRL
                     TGLIVLFLPLIVLLVNLYRKKSVVIIEKTRALLSDINAKLSESIEGIHIIQAFNQEKRL
                     KKEFDAINEEHLIYASRSISLDSLFLRPAMSLLKLLAYAVLMAYFGYRGIYLGITAGTM
                     YAFIQYVNRLFDPLIEVTQNFSTLQTSMVSAGRVFALIDERTYEPEQRDTAAKVTEGNI
                     RFENVSFSYDGKHQILDNISFSVNKGETIAFVGSTGSGKSSIINVLMRFYEFQSGRVLL
                     DGVDIRDYSQAELRKNIGLVLQDPFLYHGTIKSNIAMYQDLTDEEIKAAAEFVDANHFI
                     DKLPEGYDSPVSERGSSFSTGQRQLLAFARTVASQPKILILDEATANIDSETEAIVQNS
                     LAKMRQGRTTIAIAHRLSTIQDANCIYVLDKGRIIEHGSHEELLVLGGTYHKMYSLQAG
                     TMEGE"
     PFAM_domain     complement(12531..12977)
                     /aSDomain="ABC_tran"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00005.29"
                     /description="ABC transporter"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_1546_0147"
                     /evalue="2.20E-32"
                     /label="ctg1_1546"
                     /locus_tag="ctg1_1546"
                     /protein_end="504"
                     /protein_start="355"
                     /score="112.5"
                     /tool="antismash"
                     /translation="LDNISFSVNKGETIAFVGSTGSGKSSIINVLMRFYEFQSGRVLLD
                     GVDIRDYSQAELRKNIGLVLQDPFLYHGTIKSNIAMYQDLTDEEIKAAAEFVDANHFID
                     KLPEGYDSPVSERGSSFSTGQRQLLAFARTVASQPKILILDEATA"
     PFAM_domain     complement(13161..13970)
                     /aSDomain="ABC_membrane"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00664.25"
                     /description="ABC transporter transmembrane region"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_1546_0146"
                     /evalue="3.00E-39"
                     /label="ctg1_1546"
                     /locus_tag="ctg1_1546"
                     /protein_end="294"
                     /protein_start="24"
                     /score="135.4"
                     /tool="antismash"
                     /translation="FLALTFLLSTTVIKSIIPLVASYFIDHYLHDMNQAASMILIGYYG
                     LYLLQTLVQYLGNLFFARVSYSIVRDIRRDAFANMEKLGMSYFDKTPAGSIVSRLTNDT
                     ETISEMFSGILSSFISAIFIFVTTLYTMMILDIRLTGLIVLFLPLIVLLVNLYRKKSVV
                     IIEKTRALLSDINAKLSESIEGIHIIQAFNQEKRLKKEFDAINEEHLIYASRSISLDSL
                     FLRPAMSLLKLLAYAVLMAYFGYRGIYLGITAGTMYAFIQYVNRLFDP"
     CDS             complement(14035..15792)
                     /gene_functions="transport (smcogs) SMCOG1288:ABC
                     transporter related protein (Score: 390.1; E-value:
                     3e-118)"
                     /gene_kind="transport"
                     /locus_tag="ctg1_1547"
                     /transl_table=11
                     /translation="LFFKESIIAKLWWFFKLEKRRYIVGILALSLVSVLNLLPPMVMGR
                     VIDAITSGKLTNQILLLNLVYLLLAALGMYYLRYVWRMYILATSYRLGQIMRSRLFEHF
                     TKMSPSFYQKYRTGDLMAHATNDINSLTRLAGGGVMSAVDASITALVTLITMFFSISWQ
                     MTLVAVLPLPFMAFATSRLGRKTHKAFGESQAAFSELNNKVQESVSGIKVTKSFGYQEA
                     ELQSFQETNKMTFEKNMHTMKYDSLFDPLVLLFVGSSYVLTLLVGAFMIQAGQITVGNL
                     VTFITYLDMLVWPLMAIGFLFNITQRGNVSYQRIETLLEQESDVQDPAYPLPSIKNGRL
                     DFAIDRFAFEDEDTLRDIHFTLDKGQTLGLVGPTGSGKTALVKLLLREHDVNQGAIYLN
                     GHDIRDYRLSDLRSLIGYVPQDQFLFASSILDNVRFGNPDFSIDKVEEATKLAQVYDDI
                     KDMPEGFETIIGEKGVSLSGGQKQRLAMSRAMILNPEILILDDSLSAVDAKTEHAIIDN
                     LKHTRKNKTTIITAHRLSAVVHADLILVMQDGRIIERGRHDDLLAQGGWYAKTYGSQQL
                     EMEGGEAHA"
     PFAM_domain     complement(14287..14730)
                     /aSDomain="ABC_tran"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00005.29"
                     /description="ABC transporter"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_1547_0149"
                     /evalue="3.20E-29"
                     /label="ctg1_1547"
                     /locus_tag="ctg1_1547"
                     /protein_end="502"
                     /protein_start="354"
                     /score="102.3"
                     /tool="antismash"
                     /translation="LRDIHFTLDKGQTLGLVGPTGSGKTALVKLLLREHDVNQGAIYLN
                     GHDIRDYRLSDLRSLIGYVPQDQFLFASSILDNVRFGNPDFSIDKVEEATKLAQVYDDI
                     KDMPEGFETIIGEKGVSLSGGQKQRLAMSRAMILNPEILILDDS"
     PFAM_domain     complement(14908..15726)
                     /aSDomain="ABC_membrane"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00664.25"
                     /description="ABC transporter transmembrane region"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_1547_0148"
                     /evalue="1.20E-40"
                     /label="ctg1_1547"
                     /locus_tag="ctg1_1547"
                     /protein_end="295"
                     /protein_start="22"
                     /score="140.0"
                     /tool="antismash"
                     /translation="IVGILALSLVSVLNLLPPMVMGRVIDAITSGKLTNQILLLNLVYL
                     LLAALGMYYLRYVWRMYILATSYRLGQIMRSRLFEHFTKMSPSFYQKYRTGDLMAHATN
                     DINSLTRLAGGGVMSAVDASITALVTLITMFFSISWQMTLVAVLPLPFMAFATSRLGRK
                     THKAFGESQAAFSELNNKVQESVSGIKVTKSFGYQEAELQSFQETNKMTFEKNMHTMKY
                     DSLFDPLVLLFVGSSYVLTLLVGAFMIQAGQITVGNLVTFITYLDMLVWPL"
     CDS             complement(15980..16186)
                     /locus_tag="ctg1_1548"
                     /transl_table=11
                     /translation="MRERGQVWSYSEVKRESQLANYNTDGRYLSETTNFELYNFVREYK
                     TSDEIRRIWNPKKDESVIHDKDN"
ORIGIN
        1 ctgcttcaaa tcagcataat ctggcttatc tccaatagtt tcaattacct catcgatgat
       61 agctactgct tgttcttgtc tctctttgcc tcctgcaaac catttaagtc ctttcattaa
      121 gaaaacctcc ttatttcttt caactaattt ttcaatcaca tctttagtat agcacactga
      181 tagtcattta aaagccagcg tcacaaaaag tggctatacg tcctgaatgg tcattcatat
      241 acaaaatgaa aaaaattgag ggagatactc aatcttttaa cctatttaat ataatatctc
      301 agtgctaaca tgagtgaagc taagattgct aatgccccca caaaagagac aagtgattgc
      361 tcaccgtcat ttgttttagg gaattctttt gtgtctgcta ctttatcagt cattggtgcc
      421 atttgccctg tttgagcgtt cagttccttc tgaaccgttg acatcggctg tggttgaaca
      481 gttggcaaag atttctcttt cgtactctct tcggttactc gtgtaggacg aacagtttta
      541 gtttgaggtt cagagatggt tgtttgttcc tgattcaaag tcataaaacg tggactagag
      601 ctggctaaat ggtcataaac tgtttgagca ggtccaccac caacccatcc tgataatagc
      661 tgaccatttt ccagataaag tagtgtaggt gtacctggaa taccaatctc accaaacaca
      721 tagtttcggt caaaatcctc acgatctata tcgtaatact ctaaacgacc atccatcagt
      781 tggttcaaga ccttcaactc tggtgaaaat tgacgacaat agtaacaggt tccacgtcca
      841 aaataaatcg tatgtgcctg accatcctcg gtaaaggcat tacgcacatc atctaaactt
      901 attttaggta aatcagcaac gttagcgtcg tattcctcac gagatactgc tgggatatca
      961 ttttttgcag tctcctcctc agactcagcc aaggttactg attcagtcgc tgctggtgcc
     1021 tctttatctt caggaagcga ctgctcctga ctatctgatg gttgttctac tggagtagat
     1081 tcggttgctt caacctttgg agaattatca gctcccgttt ctaccacctc atccgctaaa
     1141 gcagttccta ccgatagatt cagtaacaag gctgaactca tcatccatag cgttaatgtc
     1201 ctttttttca tcataaactc ctttcgatta cttagtctag tttaacaatt tacaactctc
     1261 atagaagcta acgtcccaaa aagtgactat acgtcccgaa tggtaagaat ataaaaaatc
     1321 ccactatcac catgatatac tccccttata gtggacagtg aaaaaataaa aattttcact
     1381 agaaactata aggggagtct tattatgtcc aaaagaagtc caaaatctgt atctgagaaa
     1441 ctagaaattg ttctgcttca cttggaagaa ggtaaatcac ttagttggtt aactagaaac
     1501 caaggtatct ctaaagacac cctatcgaac tgggttcgga agtacaaaga agctggtgtt
     1561 gatgggctag aggaaagccg tcaatggaag aagtatagta aggaactaaa ggaacaagct
     1621 gtttccgact atcttaatgg cttgggaagt ctcaaagatc tgaccaaaaa atatggaatt
     1681 tctgaccctt atgttctcag atcatggata aaaagttata ctagtggtaa agaactgaaa
     1741 gctactagta aaggaatgag acgcatgaag caaggacgca agacaacatt tgaagaacga
     1801 attgagattg tcaattttac ccttgcccac gagaaagatt accaaggggc tgttgagaag
     1861 tatggtgttt cctaccagca gatctattct tgggtcagaa agttcgagaa ggacggttct
     1921 aacggtctcc tagatcgtcg tggaaaaggt cttacaagta aaccaaacct tactccagaa
     1981 gaagagttac gcctcaaaat caagcaacag gaagagcgga ttaagtatct tgaaatggag
     2041 aacggcctgc taaaaaagtt agaagaaatc aaacgacgaa accgacggta agacttggtc
     2101 ggcacttgga aaccttccaa gcgattaaag aatatgcgga tgagtatgaa gaggtttcta
     2161 tcagccactt gtgccatatt ctaaaggtat ctcgctcagg ctattacaag tggttacaac
     2221 atcaagaaac aacttctgaa caggaaaatt taggcttgat ggatatcatc aagaaacttc
     2281 atagccagca taatggtatt cttggttatc gtcgtatgac gctatttgtc aatcgcaagc
     2341 ttgaaacaaa ctacaacaag aagcggattc gacgcttgat gcacattcta ggtctacgtt
     2401 ccattatcag aagagccaag ggctattgta ctaaaactag ctttgtcaat gtagaggaca
     2461 acattctcaa tcgtaatttt acagccactg ctccaaatca gaaatggtgt acagatgtga
     2521 ctttcttgaa gtacggtttc agctgtaaag cctatttgag tgctattaag gatctttacg
     2581 acggctcaat tgtcgcctat gtagttggtc aatttaatga taacgaattg gtattggaaa
     2641 cacttcgtaa agcacaaaaa gctaatccta atgcgacacc attaattcac agcgaccgag
     2701 gttcgcagta tacttcgaaa gattattacc gtttaactac ccagtatcag atgacccgct
     2761 ccatgtctcg tgttggtaag tgtattgaca atgcaccaat tgagagtttc tttgggcact
     2821 ttaagacgga gtgctatgat ttgaagaagt ataagacttt tgaggagcta gtttcagata
     2881 ttgatgccta catctatttt tacaatcatc aacgttttca agagcgcaat aacggccttg
     2941 cccctcttga aatgaggaac aaggccgtcg cctaatattt tattatttca ttgtccactt
     3001 gacagggagc tgttcagtat atgttcaaga ttatttttta tgtttatttt tattgacctt
     3061 tttgaaaaag atattaccta acaaagcaac aacaaaacct ataataaaat ataccataga
     3121 ttagctccac cagcaggttg ctccataggc aacagtacca cctgcaccac ctagaacacc
     3181 accagctaga taaccaggaa ctgagcctac aactggtaaa actacattac ctccaaacgc
     3241 tcctccgata gctccttgaa cagtcgctcc acctgcgcct ctccaactac atccacctcc
     3301 ttcaacacta gcaagtgttt cgaggtcaag ggtgttaagt tttcaattgt ttgagttgcc
     3361 atggcaacta cctcctaaaa tttttatcgt gtgatctctc aatcacatct ttagtatagc
     3421 attcaagtgt ctctatcaga gctagcgtcc caaaaagtgg ctatatgtcc cgaatggtaa
     3481 ttcctaaaga acatccttca atcattggaa atcttcctct aattttcaca tatttactta
     3541 atcactttct tattataaca cttttatgca aatatcttat agattgctta cagaataatc
     3601 aagcaaatgc gtttattgtt taaaatattt tttgacttga aggtaagata gaaaatcaca
     3661 gaggattaac aaaagcatta atacggctag tactatacgg tctgtggtat cactgaatgt
     3721 tagtaatgtg taaaactcta cactaagcac tagaaatgtg atgacaggaa agacaatgaa
     3781 ggactgccgt attgttaaca gatttactga atctggacgc ttcttaagca tacggtagag
     3841 cagtccatta acaaaaatga ctacgaaagc tagtgctccg actgctagcc aagttcctgg
     3901 cgagatcttg cttttgtaga gagaaaggct gatacttata aggaaaactg ccaacgcagc
     3961 agtgatggtt ctaaaagatc gcaatacact cgaactaata ttctttaact tcatgataaa
     4021 acacctaaac tatgaataac ctcagtcagt cttgcaaacc taataagcta ttacatttaa
     4081 ctctattcct ctctgtattt tattatacag ctgtaagatt tcaagtaagc ccttagcgat
     4141 taaattctac tggagatgta atacagtagt gtcattagta ctgatacttt aaataggcga
     4201 atatacatat ctttgttttc tctattacaa agatatgcaa tcaaatataa tataatctcc
     4261 gctatcatta gcaagaataa ttttacttcg ggaacatcaa aaataagcat ttgcaagcat
     4321 cttacgttca aagtgaccaa aggttacttt tgaaactgta cccacttttt aaaaagtaag
     4381 ctataaagaa gcaccgttag ccctagcaag ttaatggtat ggtgaactgc atccaagctt
     4441 ctaaatagat tagcgaggcc cattacgatg agaatggtag ccagtaaata cggttttgag
     4501 tttttaaaca tacttttctc cttaaagtgt ttttagctag tctgtgcata atctatgaat
     4561 tttattatag attggaagcc gataaaaaag tagtgacata aatgtcacta cttgtctgac
     4621 cttatatcct tgataaccgt acacataaga aaaagaaata aacataaccc gataagattt
     4681 aggcattgaa gtccaaaatt cagtttttct ccaaagttat gtaaggcaac aaggacgaag
     4741 cccatagaca tcattagaga cactaggcgt tttttggtca tgattacaaa tacctcttct
     4801 cttatatcga aattttcaat cataattcac atgctattca cagaccagca attgacaaga
     4861 catttcagtt aggatttctt cttaacggaa ttggtagcct tgtgtttttc aagaaatgac
     4921 ataattggct tatctaaaaa actcataaca gccatggaaa ccatccctaa aatataactt
     4981 ttcaaatcaa acataatcca tcaccaccag catgttgctc cataaccaac accacctacg
     5041 atagcacctc cagctgctcc tgcgacagca ccttgccaag tacgtgtttt gatacctagt
     5101 cgtaaaccat taccaactcc tgtagctact ccttgtttag caaaacctcc ccagctacat
     5161 ccaccacctt caacactagc aagtgtttcg aggtcaaggg tgttaaagtt ttcaattgtt
     5221 tgagttgcca tggcaactac ctcctaaaat ttttatcgtg tgatctctca atcacatctt
     5281 tagtatagca ttcaattgtc tctatcagag ctagcgtccc aaaaagtggc tatatgtccc
     5341 gaatggtaat tcctaatgta tattatttct aaaattcaga aaaaaatctc attttatact
     5401 cataaaaaaa tgaaaaaccg ttttctttat gttacaattt ttcaataaac agtattcgtc
     5461 ataaaagaga ggactagacc ttgaagattt acctattaga agataattct attcagatgg
     5521 gtcgcttgga agaggctgtg gcacatgaac ttaaatcctt cggaaaagat ctatcttgtg
     5581 tccagtcttt tgacaaacct gaccagttgt tatcagctat cacttctaat acaagcgatc
     5641 agattttctt tcttgatatt gaaattaaag gtgaagataa gaagggactt gatatcgcta
     5701 aaatcgtacg tcaaaataac ccttatgcta tcattgcctt tgtcactaca catatagagt
     5761 tcatgcctca agcttttggc gttacagcct ataaatacat caataaaacc ttagatgaag
     5821 ctagctttag aaaagaaata ggggaaacca ttgctcaagt cttccctatt aacgcaacta
     5881 ccacggatga gttttttctc tacaaaacag agtctcaatt aataaacctt cctatggatc
     5941 aaattctata cctatccaca tcagatatca aacaccatgt tcacctccag actatccata
     6001 ccctcatgga tatccgagca aatctggcag actttaaaaa gatacacaaa aagctctacc
     6061 catgccatcg gtcctatatc gtcaatacag atatgatcat ctctgtcaac aagaccaatt
     6121 atgaagctac cttaattaat ggtcaagttc taccagtatc ccgtatgaag ataggaaaga
     6181 ttgcacagat tgttgaggaa agaggcagat gatgttaaca acgttatggc tactttttct
     6241 caccctttta agtgcaggcc tagaaattat tcttttcctt tatttaatgg gacagaagat
     6301 tcgtctgagg tattttttcc tactccttat ttttaattta gcctttaatt ttatttataa
     6361 ccactcttct tggtttatca ttaaattctg gggtgaggat atctactatc ttctgctctc
     6421 cttcctttta tccactaaga ctaaaaaacc attaaaaata aagattttca atggtctctt
     6481 ccctgatatc ctcaacaacc ttagtttaag actgattact ttttttatct ttcctttttt
     6541 taatattagt atcaccgatt ataaaagctc tctattaata tccatccctt catctatcgc
     6601 acctctttgt ctatcatttc tctttattaa attattcaag gagagtttta ccatacttca
     6661 aaagcagaaa tcaaattctc cgattcaaca tattattata gttgctaact tttttatgtt
     6721 tgggtacacc ctactgttac agtccctcat gtatcttgaa aacactactc actcttcaac
     6781 tttggagctt cgaaaactct gtgttgttat ttcacttgtc ctcttcttca ttatgattgt
     6841 ctttttagaa agaaacattc gtgaaatgat tcaaggacaa ttggacttcc agaaaaatct
     6901 ccagctagag aatctctaca cctacaataa acatattgaa tgtctctaca attctgttcg
     6961 tagttttaga cacgattata gtaatctctt agtcacatta cgattgggga tagataaaga
     7021 cgatatggat attgtcaaag aagtctatga tagtgtgctt caagaatccg ataaacgatt
     7081 aaatacaaga aactttgact tagctagact cgttaatatt caggataata ctttgaaaag
     7141 ccttctgtcc gcaaaagttt tacaagcaga agaagaaggt attgaagctc agattagcat
     7201 cccagaaccc atccacttga ttgggatgga gattctggac ttcattatcg tcacttctat
     7261 ttttttagat aacgctattg aaggtgccat tcaaactcaa aaccataaaa ttactattag
     7321 cttttgggaa gatcatcgtt cacagctatt atctattagc aataccataa gtgaagaaca
     7381 aacagaaact aaaaccatat ttgaaagagg tgtctccaac aagggacgag agcgaggcat
     7441 tggccttgct aatgtcacag aaatcttaga taactatatc aatgtaaact tagaaacaca
     7501 gagtaacaat ttctcattca cacaacaatt aacaataact aaaaaggcct aacagccttt
     7561 tttctatacc taaacttgag gaatgttata gtcttttgtt ggaagcgttc tttgccctcc
     7621 gaatcctttt aggaaaccat ttatataatc catccaccca cttccaccta cgacttgttc
     7681 aagagcgtgg ttatcaagtg tttcaaagtt attaatcgta ttgttagcca tcggtaattc
     7741 tcctcctatt ggtcttgcaa gtttagtaac ttgtctttaa agtaattgaa gtaggtcttt
     7801 tggtcaataa cgcttgtcac acgactttct agaccgtaac gtagattttg ggcttctttt
     7861 tctgaaatac ttgccctagc agttactcta aacacattcc ccctttctgt ttccgtggca
     7921 gaattatcaa tactctcaag ttttccaata attgtggtac cgtgattacc aaccttatcc
     7981 aaggtcagtc gaactgactg gcctttttgc agttttggca cataatccga attcacataa
     8041 taagtaatgg caacttcctg ggtttgagtc atatcgggat aaagctgggc caactcagtt
     8101 cctgtcgcag ccatggttgc ttttttatca gcttgactca agtgtaagat tccatcttct
     8161 ggtgactgga tgagggtatt agtcagaagg acatctgcct gattgatttt actctcggta
     8221 tcggtaattt gtgtttccac tgagctcaat tgctgtcctg cattttgcaa gaattgattt
     8281 tttagagctt cttttttagt gctatcacta ttgtcataag ttacaactgt gcctgtccca
     8341 gccttttgga tttctagatt acctatggaa gcattcaagc tcgaaatatt ggtattaact
     8401 tgagataggt attggtctgt tacactggca tccggtgtcg tagcatactg actgttatag
     8461 gcatttaagg ttgcctgatg aggattgcct tcaggtaaag tcgtttcatg attggtaata
     8521 gcttgagaga gcgcctcata ctctgagacc tgagtctgca attgactaat ctggttatca
     8581 atagcagaac cggtattact cgcaattgct gcttggttat taacctctgt atttgtttta
     8641 gccacaccca agtcaataat cctgtgcctg acttaggtag gtgttaaaag tactctgata
     8701 accaaactcg tcttcctgtt cttggaaaag attggttccc tgcgttaggc tagattgcaa
     8761 ggtcttcaaa cctgattcct atctttttaa aagttctagt tgcttttgaa gcccctcttt
     8821 ttgcgatgcc tccatggtct ctgaatactg aactaaggtg tccccttttt taacaacctt
     8881 attagcaacc agttgattat ctatgatggt attgtcactg gttgattgga ttactgcgat
     8941 aaccttggtt ggctctatac ttcctctaga cgtgactgta acttccttct tagcaaaaaa
     9001 agcgaaaaga aaaaggaaaa taactaacaa aatcaaggga gtaatcaaaa cagtagacat
     9061 attgtggtag cgacgatggt aaaactctgt gcttttaaac aactgtggat tcatcgtgtt
     9121 tccttttcct cactttctaa ataattgata atagaaacct ggataagaca tcaggtcttg
     9181 atgagaacct gtctccacta cgcgtccctg atcaatgact acgatacggt cggtccgctc
     9241 agcgatacta agcctgtgtg ctacaaagat gatcgtttta tcttttagtg ctaggaggtt
     9301 atcaataacc tgcttttctg tcaaaacatc caatccgcta gttgcttcat ctaagattag
     9361 tacaggagat ttcgttagta gtgcacgcgc caaagcgata cgttgctttt gccctccaga
     9421 cagacctgct ccatcagaca gctctgtctg aaaccccata ggcatgtttt caatatcttg
     9481 acgaatttct gctatttcac aagctttcaa aatatcagct tgcgtaatac cccgtgctgc
     9541 acctaaagta agattttcta aaacactacc actaaatata taggattgct gagggagata
     9601 gttaatatgt tgacgaagag ttttcttgtc tatgcgacta atattttgac cattaaaatc
     9661 tatgtgcccc ttatatggtt gataaaaatt gaccaacatt ttagctagag tagtcttacc
     9721 agatccactg acaccaacaa aactgatttt ttctccttgt ctaatcgtca aactgacatc
     9781 agtcaaagta tcacgaccaa aaccatattt ataagataaa tccgtaacag tgatatctcc
     9841 atccgcaatg ccttcttgat aggtatcatc actttgtcca aactctgatt caatcagata
     9901 gacctcattg agcctagtat tagctacctt agcagactgt aacttggttt gcaggttaat
     9961 gatattttcc aaaggattcg tgaagtaaga aagcaacata ttaaaagtaa tcaattgtcc
    10021 tatcgaaatg gtatttccca tcaccaactg agcacctgtc cagaggataa gtacatttaa
    10081 aataagttga gcaccttgtt tcaatgatgt ttgtagtata gataacttag aaaggcgaaa
    10141 agaattgtct agatagtcaa caaactcacc atcaatcttt tgatagcata cttcttcgct
    10201 ggttagtgac tttatggttt caatcccatt aatgtcctca atgatggctg aattaaccat
    10261 agcattactc tgcatgacgt catgattcat tcgctcaaaa ggtttcataa aggcaaagac
    10321 gataagggta taaattggaa ccgaacaaag aactagcttg aagagattgc tattttgtat
    10381 caataacacg cctcctacga taatcacaat agagaaatca aggaaaagtg ataatatcgt
    10441 cgaagccaga gcatcgataa tagagttagc atcactaaaa cgtgagataa cctcccctgt
    10501 acgtcttgtg gcaaaaaaag acattgggag ttcaaagata tgtcgtatgt aggacaagat
    10561 aacgtcaatg gtcaatcgct gactcagtat ggttaagaga taatctcttg caaaagtcat
    10621 catttgttgt aaaacatagg tcacaactaa tccaattgag ataattccta aggtagactt
    10681 catttgatta gggacatatt cgtctagaat accttgtaaa taataggaac ctaaaatatt
    10741 tattaaagta accaagagac tggcaaagac aatattagct atcaaggacc tttgtttaaa
    10801 gatcaaaggg agaaagtccc agagtccatt tttcttatcc ttatgtggtt tataactggg
    10861 ttccggtccc ataaaaagag taacacctgt ccactctttc tcaaaacgct ctttagtcat
    10921 tttagttact tttacacttg gatcagggtc tccaattatc agataatcct tggtgctttt
    10981 ataaataaca taataatgtt gaagcttccc atctttatta acatgagcaa taaaaggata
    11041 aggaacatct tccatctcaa agagcgacat ttcagccttt atagctctcg tttcaaagcc
    11101 aattttttta gcagcctcta caagacctaa ggcagttgtc ccttctttat tggtcttcgc
    11161 caactcacgc agatgtgcta atgaataatc tgaaccatag tacttggcca ctgatgccaa
    11221 ggcagcaact ccacaattcc tcatgtctat ttgagggaca aaagtcctac gaaaacgaaa
    11281 cataccaaac cctttcatca caaattatca tatgattagt atgtcatatt ttcaggataa
    11341 aaagagccag cgtcccaaaa agttgccata cgtcccaaac ggtaagaaaa atcttaaagt
    11401 catctccact attaccactt aagccgtatt tggggtcatt taggacaagt tcattgaaat
    11461 cgatttcaaa gttatacaat agttattaga aggaaacatt ctaaaatagt cctacaagca
    11521 tacgtatttg atctaaccat tattactgtg ccagccctgg tatttccaaa ggaaaccatg
    11581 actgctgata gcctcggagc ctatctctat cgtatgatgt cataatttga ttatttttat
    11641 tccgaaaagg gataacatta tgaaaaacgt caatccatat ctcaaaaaat cctatcaaaa
    11701 aaggctaaat cagcctcttg agattcgatt actcaattat cggtttaatt ttccttagct
    11761 ttgtaagtgt atttgttatc actgtcaatg ctatttttag cgtcactaga ggggttccct
    11821 tccttaatgc ccaccttatt tccaccttga gtaattgtgc cttctatctt ttgatttact
    11881 caaccttgag gtggcaccat ctcaaaaagc tctataatct ctacagtggt ttttcccact
    11941 acagaaatta tagagccgaa gttaagtagt tctgtggtaa actgagtcat aggaataaat
    12001 ctctttctag taatgttttg caactctact ataacggatt tattcctttt tgtgtttaca
    12061 caacttattt tacactacct caacgtttgc aagtacctcg agatcgagtg tttcaaatgt
    12121 attatttgtt tgccttgtca ttctaacaac ctcctaaatt atttttagct ttttctctca
    12181 agctatgatt ttattatagg gtggtagcca acaaaaaagt agtgacataa atgtcactac
    12241 tcgattttga tttttaagaa atcttttcga atatagaagc tatggtctag attagcttac
    12301 tctccttcca tggtgcctgc ttgtaggctg tacatcttgt gataggtgcc gccgaggact
    12361 aggagctctt cgtggctacc gtgttcaatg atgcggccct tgtctaagac atagatgcag
    12421 ttagcatctt ggattgttga taggcggtgg gcaatggcaa tggttgtacg gccttgacgc
    12481 atttttgcaa gagagttttg aacaatagcc tctgtctccg aatcaatatt ggctgtcgct
    12541 tcatccaaaa tcaagatttt aggctggcta gcaacggttc tagcaaaggc tagaagctgg
    12601 cgttgaccgg ttgagaaact tgaaccacgt tcggaaactg gggaatcata gccttcagga
    12661 agtttatcaa taaagtgatt ggcatcgaca aactcagcag cagctttaat ctcttcatca
    12721 gttaaatctt gatacatggc aatattggat ttgattgtgc catgatagag gaaggggtcc
    12781 tgaaggacaa gaccaatatt cttgcgcagc tctgcctgac tataatcacg aatatccaca
    12841 ccgtctagga gaactcgtcc tgattggaac tcatagaatc gcatgagcac gttgataata
    12901 gaggattttc cagagcctgt agatcccaca aaggcgatgg tttcaccttt attgacagag
    12961 aaggaaatat tatccaaaat ctggtgcttg ccatcatagg agaaggagac attctcaaag
    13021 cgaatattcc cctcagtaac cttggcagct gtgtctctct gttcaggctc ataggtacgc
    13081 tcgtcaatca aggcaaagac ccgacctgct gagaccatag aggtttgtag agtcgagaag
    13141 ttttgtgtca cttcaatcaa gggatcaaag aggcgattaa catactggat aaaggcatac
    13201 atggtacctg ctgtgatacc cagatagata cctcggtagc caaaataggc catgagaaca
    13261 gcataagcca ggagcttcag tagactcatg gctgggcgta gaaagagaga atccagtgat
    13321 atagaacggc tggcataaat caggtgttcc tcattaatgg catcaaactc ttttttaaga
    13381 cgcttctcct ggttaaaggc ctgaatgatg tgaatccctt cgatactctc tgacagtttg
    13441 gcatttatat ctgaaagcaa ggctctggtc ttttcaatga tgaccactga ttttttgcga
    13501 taaaggttaa ccaaaaggac aatcagagga agaaagagga caataagccc ggtcagacga
    13561 atgtccaaga tcatcatggt gtaaagggtg gtaacaaaga taaagatagc cgaaataaaa
    13621 ctagacagaa ttcctgagaa catctcgcta atggtctcag tatcattggt caagcgggaa
    13681 acgatggaac ctgctggggt cttgtcaaag taagacatac ccagtttttc catattggca
    13741 aaggcatctc gacgaatatc tctgacaatg ctataggaca cacgcgcaaa gaagagattt
    13801 cccagatact ggactagtgt ctgcaagagg tagagaccat agtagccaat cagaatcata
    13861 cttgccgcct gattcatatc atgaagatag tgatcaataa aataagaggc caccaaggga
    13921 atgatactct tgataaccgt tgtggacaag aggaaggtca aagctagaaa ggtcaagaac
    13981 ttgtaaggct tgagataggt caagagacgc ttaaacacag accattggtt ttgattaggc
    14041 atgagcttct cctccttcca tttctaactg ttgagaccca taggtcttgg cataccaacc
    14101 accttgagct agtaagtcgt catgacgccc acgttcaatg atacgaccat cttgcatgac
    14161 caggatgagg tcagcgtgca ccaccgcact gagacggtgg gcggtaataa tagttgtttt
    14221 gttcttgcga gtatgcttaa gattatcaat aatggcatgt tctgtcttag catcaaccgc
    14281 agataaggag tcatccaaaa tcaaaatttc tggattcaaa atcatggccc ggctcatagc
    14341 cagacgttgt ttttgaccac ctgataggct gacacccttt tcaccaatga ttgtttcaaa
    14401 gccttcaggc atatccttga tatcatcata aacttgagct aacttagtcg cttcttccac
    14461 cttatcaatg gagaaatctg gattaccaaa gcggacattg tctaaaatag aactagcaaa
    14521 gagaaactgg tcttgaggaa cataaccaat caagctacgc aagtctgata ggcgatagtc
    14581 tcggatgtca tgtccattca aatagatagc tccttgattg acatcgtgct cccgcaagag
    14641 caacttgaca agagccgtct ttcctgagcc agtcggtcca accaaaccaa gggtttgccc
    14701 cttgtccaag gtgaaatgaa tatctcgcaa agtatcctca tcctcaaaag caaagcggtc
    14761 aatcgcaaag tctaaacgac catttttaat gcttggaaga ggataagcag gatcttgaac
    14821 atctgattcc tgctctaaaa gagtctcgat acgttggtag gacacatttc ccctctgcgt
    14881 gatattaaag aggaagccaa tggccattag gggccaaacc agcatgtcca aataggtaat
    14941 aaaggttacc aaatttccga ccgttatctg accggcctga atcataaagg ccccgacaag
    15001 gagggtcaaa acataagatg agccaacaaa gagcaagacc aaaggatcaa aaaggctgtc
    15061 atacttcatg gtatgcatat tcttttcaaa agtcatctta ttggtctctt ggaaggactg
    15121 gagctcagcc tcctgatagc caaaagactt ggttaccttg atacctgaca ccgattcttg
    15181 taccttatta ttaagttcag aaaaagctgc ctgggattct ccaaaagctt tgtgggtctt
    15241 acgtcccaaa cgactagtcg caaaagccat gaaaggtaga ggtaagactg ccaccagggt
    15301 catctgccag gaaatgctga agaacatggt gattaaagtc accaaggctg tgatagacgc
    15361 atccacggct gacatgacac ccccaccagc caaacgggtt agagagttga tatcattggt
    15421 ggcatgggcc atgagatcac cagttcggta cttttggtaa aaagaaggcg acatcttggt
    15481 aaaatgctca aaaagccgcg aacgcataat ctgtcccaag cgataagacg ttgccaagat
    15541 atacatccgc caaacatagc gcaaatagta cattcctaaa gccgccaaaa gcaaataaac
    15601 gagattcaaa agcaagatct gattggtcaa ttttcccgat gtgatagcat caatgacccg
    15661 acccataacc ataggaggaa gcagattgag aaccgaaacc aaactcagtg ccaatatccc
    15721 gacaatataa cggcgttttt ctaacttgaa aaaccaccaa agttttgcaa tgattgattc
    15781 tttaaaaaac aagttattcc ccctatccct acaaaaggat gattataagt ctaatgaaag
    15841 ttatttccaa tagcgataaa ttgtaccatc ttctaactga aagtgaccaa tataagtcaa
    15901 ttttccaaaa tcagtagact ctggcaattg ataagcaaag gagtcaaaat tatagacctt
    15961 gtgcccatca tcaatagaat cagttatcct tatcgtggat aactgattcg tccttcttag
    16021 ggttccaaat acgtctgatt tcatcagatg tcttatactc tctgacaaaa ttgtacaatt
    16081 cgaagttagt tgtctcactg agatagcgac catcagtgtt gtagttagct aattgagact
    16141 ctcttttaac ctcagaatag ctccaaacct gacctctttc tcgcataata tcggcatcac
    16201 ggccactttt gataagtatc tgctttaacc gctgtcattg ttgctcatag tgtcaataca
    16261 gtgactactg tcacattaag tgt
//
