LOCUS       NZ_CP022046.2          10294 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  NZ_CP022046.2 Mammaliicoccus sciuri strain FDAARGOS_285 chromosome,
            complete genome.
ACCESSION   NZ_CP022046
VERSION     NZ_CP022046.2
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 6.1.1
            Run date     :: 2024-03-14 15:01:54
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 1829798
            Orig. end    :: 1840092
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..10294
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[1834798:1835092](-)"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193)"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(5001..5294)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193)"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
     cand_cluster    1..10294
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193)"
                     /kind="single"
                     /product="RiPP-like"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..10294
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="RiPP-like"
                     /region_number="2"
                     /rules="(strepbact or Antimicrobial14 or Bacteriocin_IId or
                     BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or
                     Lactococcin or Antimicrobial17 or Lactococcin_972 or
                     Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or
                     TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or
                     TIGR03975 or DUF692 or TIGR01193)"
                     /tool="antismash"
     CDS             complement(833..1681)
                     /locus_tag="ctg1_1786"
                     /transl_table=11
                     /translation="MIKIGLTGWGDHDSLYEDLSNKKDKLKAYAAHFPIVELDATYYAI
                     QPQRNIEKWIRETPNNFKFVVKIHQALTGHAEITDFAEDKMTLFNLFKDSMAPLKASGK
                     LAMILVQFPPWFDLQPQNINYLRYVREQLKDFDVCIEFRNRTWFKEDVKEYTLEFLTEM
                     KFIHSVCDEPQSGEGSIPLINRITHDVAFVRYHGRNVNGWTKKDMTDQEWRDVRYLYNY
                     NEAELKELADKVKILEHKAKDVYVVFNNNSGGHAAQNAKTYQKLLDIEYEGLAPKQLKL
                     F"
     PFAM_domain     complement(890..1624)
                     /aSDomain="DUF72"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF01904.20"
                     /description="Protein of unknown function DUF72"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_1786_0024"
                     /evalue="3.90E-58"
                     /label="ctg1_1786"
                     /locus_tag="ctg1_1786"
                     /protein_end="264"
                     /protein_start="19"
                     /score="197.2"
                     /tool="antismash"
                     /translation="SNKKDKLKAYAAHFPIVELDATYYAIQPQRNIEKWIRETPNNFKF
                     VVKIHQALTGHAEITDFAEDKMTLFNLFKDSMAPLKASGKLAMILVQFPPWFDLQPQNI
                     NYLRYVREQLKDFDVCIEFRNRTWFKEDVKEYTLEFLTEMKFIHSVCDEPQSGEGSIPL
                     INRITHDVAFVRYHGRNVNGWTKKDMTDQEWRDVRYLYNYNEAELKELADKVKILEHKA
                     KDVYVVFNNNSGGHAAQNAKTYQ"
     CDS             complement(1981..2613)
                     /gene_functions="transport (smcogs) SMCOG1000:ABC
                     transporter ATP-binding protein (Score: 195; E-value:
                     2.5e-59)"
                     /gene_kind="transport"
                     /locus_tag="ctg1_1787"
                     /transl_table=11
                     /translation="MIRLNNLRKQFNGVNLFSDLSLNINKGEMVAITGRSGSGKSTLLG
                     CMCGLEKNDGGTIYIDGDDITKMKRKHKMLLYRNKLGYLFQNYALITHETIEHNLDIVL
                     TYKKLSKSQKKVLKNDVMKKVGLNKPLNTKIYTLSGGEQQRVAIARLLLKEPLIIFADE
                     PTGALDNDNKYKILELLSEFKGKSTILIVTHDEEVMKYCDRNIQLAT"
     PFAM_domain     complement(2119..2562)
                     /aSDomain="ABC_tran"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00005.29"
                     /description="ABC transporter"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_1787_0025"
                     /evalue="5.10E-35"
                     /label="ctg1_1787"
                     /locus_tag="ctg1_1787"
                     /protein_end="165"
                     /protein_start="17"
                     /score="121.1"
                     /tool="antismash"
                     /translation="SDLSLNINKGEMVAITGRSGSGKSTLLGCMCGLEKNDGGTIYIDG
                     DDITKMKRKHKMLLYRNKLGYLFQNYALITHETIEHNLDIVLTYKKLSKSQKKVLKNDV
                     MKKVGLNKPLNTKIYTLSGGEQQRVAIARLLLKEPLIIFADEPT"
     CDS             complement(2610..2972)
                     /locus_tag="ctg1_1788"
                     /transl_table=11
                     /translation="MKKLIYTLIASIMIICIILFTMKNIDEKLDVVNPFVKRGWSYAKV
                     PYSSDAEHLSKQEIINIQDYKDIESYDENGHKNNYLLDFKGHSPSEQYVKIDHKGKWVY
                     FIEYISKSEYEKMIKQ"
     aSDomain        complement(2631..2972)
                     /aSDomain="TIGR01655"
                     /aSTool="tigrfam"
                     /description="yxeA_fam: conserved hypothetical protein"
                     /detection="hmmscan"
                     /domain_id="TIGRFam_ctg1_1788_0004"
                     /evalue="4.10E-12"
                     /identifier="TIGR01655"
                     /label="ctg1_1788"
                     /locus_tag="ctg1_1788"
                     /protein_end="114"
                     /protein_start="0"
                     /score="44.7"
                     /tool="antismash"
                     /translation="MKKLIYTLIASIMIICIILFTMKNIDEKLDVVNPFVKRGWSYAKV
                     PYSSDAEHLSKQEIINIQDYKDIESYDENGHKNNYLLDFKGHSPSEQYVKIDHKGKWVY
                     FIEYISKSEY"
     CDS             complement(2972..4975)
                     /locus_tag="ctg1_1789"
                     /transl_table=11
                     /translation="MKKITKITIFLIFCIITFIFLNFYNYIDDIKLPGYNKALVIEKWD
                     KKHNKEEINRLLVKLSTEHNISMIRVNGNYDDNGKTKYLSQYNLNEKLNFNEKAFNRNK
                     KYQIIKPDNKILGKLNLVGTTFFIKENPKSDFYETLEEKGLTTKDYEFPLHLIILEYIS
                     THQLPSTFIILLVIIFIAILYDQLASVKEMSIKRIHGFTSAKIIALQLLKITKIFVSHF
                     IIITLIVTIGLYLYNQLAQIRYIFWSYLICVVIFYIILIMVSLMSYWLVSKQTFNIQKY
                     IKFEGVGNRFQYLPNIIKLIVTLTLLNVISISIHNYIEAFDIVNSEKHWFKNKDLYIAE
                     LTTNEIETSKKQFKYSDQEVINLLNKIPEKNWMLTFHRHYNWKKSGEKYDLDNAIYVNK
                     TFIDRNKISIENKESVDFSKITALIPDKGFSKENINKIKEDLQEEIEFYDEIEKVPNKQ
                     RYLDIKVHKIKNNYNLFNYSTGVYSKEVISYNPVIIILPKGYYPISFYSSATSQGLLLF
                     NDYDLIKSKLDNNKFDTEIQGLTNAYSSVLTEYNKIKRNLFVSVTTSILGIIILISVYL
                     FIINIYCDKEKKVIFVRTIHGDSFFKKHISFVINSLVSTFIALFIVNFFDIVEISFKLM
                     ISIILFELLTVMIFINRYEYHLLKDARRGETQ"
     CDS             complement(5001..5294)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: Lactococcin_972"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg1_1790"
                     /sec_met_domain="Lactococcin_972 (E-value: 1.1e-18,
                     bitscore: 64.8, seeds: 6, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKKFFITLLLTIIIASGAGIVKAYQVNVDGGTWNYGVSSQYVWSN
                     YYHGKKTHYTSVRGRYWATSGYTPKGRWSKVSAQKRPGWQIWKVNKAYYGFY"
     PFAM_domain     complement(5013..5210)
                     /aSDomain="Lactococcin_972"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF09683.12"
                     /description="Bacteriocin (Lactococcin_972)"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_1790_0026"
                     /evalue="8.20E-12"
                     /label="ctg1_1790"
                     /locus_tag="ctg1_1790"
                     /protein_end="94"
                     /protein_start="28"
                     /score="45.6"
                     /tool="antismash"
                     /translation="DGGTWNYGVSSQYVWSNYYHGKKTHYTSVRGRYWATSGYTPKGRW
                     SKVSAQKRPGWQIWKVNKAYY"
     aSDomain        complement(5043..5294)
                     /aSDomain="TIGR01653"
                     /aSTool="tigrfam"
                     /description="lactococcin_972: bacteriocin, lactococcin 972
                     family"
                     /detection="hmmscan"
                     /domain_id="TIGRFam_ctg1_1790_0005"
                     /evalue="1.10E-11"
                     /identifier="TIGR01653"
                     /label="ctg1_1790"
                     /locus_tag="ctg1_1790"
                     /protein_end="84"
                     /protein_start="0"
                     /score="42.9"
                     /tool="antismash"
                     /translation="MKKFFITLLLTIIIASGAGIVKAYQVNVDGGTWNYGVSSQYVWSN
                     YYHGKKTHYTSVRGRYWATSGYTPKGRWSKVSAQKRPGW"
     CDS             complement(5549..6802)
                     /locus_tag="ctg1_1791"
                     /transl_table=11
                     /translation="MLTAITYLTKKGWEISSDPRTYDQYPKNYGYRNYTEDGINYDAYC
                     SGYHRAFDVYSNETNQIPAVTSGTVILSEPFGNFGGTIEIRDNNGNDWIYGHMQRDTLQ
                     FSKGDKVIQGDIIGLQGNSNYDNNPMSEHLHIQLRQKGEDISKEVTRVCSGMPIENYDI
                     SKLNQKLDQSNNKGAVKMSRKIMIVAGHGYNDPGAVGNGTNERDFIRTNIVDRVANYLK
                     QAGHKVAVYGKDQDMYQDTAYGDQVGNKKDYGLYWVKSQGYEIVVEFHLDSAAASATGG
                     HVIIPSGLAADSIDKALQAAVKKHVGTIRGITERSDLLHCNVAKAEYINYRLVELGFIT
                     STKDMNYIKNNLNAYTKSLAEAINGGAINTNPTTYTVVAGDTLWSISQKTGVTVATLKK
                     LNGLTSDVIQIGQVLKLK"
     PFAM_domain     complement(5555..5680)
                     /aSDomain="LysM"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF01476.22"
                     /description="LysM domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_1791_0029"
                     /evalue="7.70E-15"
                     /label="ctg1_1791"
                     /locus_tag="ctg1_1791"
                     /protein_end="416"
                     /protein_start="374"
                     /score="54.8"
                     /tool="antismash"
                     /translation="YTVVAGDTLWSISQKTGVTVATLKKLNGLTSDVIQIGQVLKL"
     PFAM_domain     complement(5714..6250)
                     /aSDomain="Amidase_3"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF01520.20"
                     /description="N-acetylmuramoyl-L-alanine amidase"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_1791_0028"
                     /evalue="5.20E-29"
                     /label="ctg1_1791"
                     /locus_tag="ctg1_1791"
                     /protein_end="363"
                     /protein_start="184"
                     /score="101.6"
                     /tool="antismash"
                     /translation="IMIVAGHGYNDPGAVGNGTNERDFIRTNIVDRVANYLKQAGHKVA
                     VYGKDQDMYQDTAYGDQVGNKKDYGLYWVKSQGYEIVVEFHLDSAAASATGGHVIIPSG
                     LAADSIDKALQAAVKKHVGTIRGITERSDLLHCNVAKAEYINYRLVELGFITSTKDMNY
                     IKNNLNAYTKSLAEAI"
     PFAM_domain     complement(6368..6661)
                     /aSDomain="Peptidase_M23"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF01551.24"
                     /description="Peptidase family M23"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_1791_0027"
                     /evalue="3.00E-16"
                     /label="ctg1_1791"
                     /locus_tag="ctg1_1791"
                     /protein_end="145"
                     /protein_start="47"
                     /score="59.5"
                     /tool="antismash"
                     /translation="YHRAFDVYSNETNQIPAVTSGTVILSEPFGNFGGTIEIRDNNGND
                     WIYGHMQRDTLQFSKGDKVIQGDIIGLQGNSNYDNNPMSEHLHIQLRQKGEDI"
     CDS             complement(6823..7143)
                     /locus_tag="ctg1_1792"
                     /transl_table=11
                     /translation="MVKMNFKTDKVNLNYSEEDNRIPIEPDKVKQFIAMIGGFLGALYL
                     ALNASGFSVEWLNPQKLNAWMNVLNTGIPIVFVLYGIWKNTFIFTNQSREQEKFLKQSG
                     KK"
     PFAM_domain     complement(6838..7065)
                     /aSDomain="Holin_SPP1"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF04688.15"
                     /description="SPP1 phage holin"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_1792_0030"
                     /evalue="9.70E-09"
                     /label="ctg1_1792"
                     /locus_tag="ctg1_1792"
                     /protein_end="102"
                     /protein_start="26"
                     /score="35.4"
                     /tool="antismash"
                     /translation="DKVKQFIAMIGGFLGALYLALNASGFSVEWLNPQKLNAWMNVLNT
                     GIPIVFVLYGIWKNTFIFTNQSREQEKFLKQ"
     CDS             7286..7615
                     /locus_tag="ctg1_1793"
                     /transl_table=11
                     /translation="MVSQNKLSEQISLLRTKNGWTQQKLADALQVSKQSISYWETGRKA
                     PKMKKIEEMAKLFDVSVSYILDGEAKQTYNSTAETIAAHLDGELTEEELKKVLEYVDFL
                     KHQNK"
     PFAM_domain     7322..7480
                     /aSDomain="HTH_3"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF01381.24"
                     /description="Helix-turn-helix"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_1793_0031"
                     /evalue="1.00E-14"
                     /label="ctg1_1793"
                     /locus_tag="ctg1_1793"
                     /protein_end="65"
                     /protein_start="12"
                     /score="54.4"
                     /tool="antismash"
                     /translation="LLRTKNGWTQQKLADALQVSKQSISYWETGRKAPKMKKIEEMAKL
                     FDVSVSYI"
     CDS             7647..8111
                     /locus_tag="ctg1_1794"
                     /transl_table=11
                     /translation="LNRYEKTLINNEHIVIKETSNLPNQLKGLYVDGLILLKDDLSNKE
                     KLEVLGEELAHHDISYGDILDTSELWKWKFEHKARRLGFEKIIPLKSIVQAYQSGVHNK
                     FELSNYLDVSEGYIDEALEHYKQKYGLSTWYDHYLIKFNPLQVYEYREIN"
     CDS             complement(8166..9314)
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1268:mandelate racemase/muconate lactonizing enzyme
                     (Score: 326; E-value: 3.9e-99)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg1_1795"
                     /transl_table=11
                     /translation="MKIVDYELFQVPPRWLFLKITTDEGIVGWGEPVIEGKAQTVGAAV
                     DEFMQQLIGKNPLNIEDHWNMMYRSSFYRGGPILMSAISGIDQALWDIKGKYYNAPVHE
                     LLGGACRESMKVYSWVGGDRPQDTANAAKKAFENGFEAIKMNATEELQYIDSYDKIESV
                     VQRVAGIREAVGNQLGIGIDFHGRVHKPMAKVLAKELEPYNPMFIEEPVLSENIEAVRE
                     ISQTTTIPIALGERLFSRWDFKPILESGFVDIIQPDLSHAGGITECKKIISMGEAYDVG
                     AAPHCPLGPIALASCLQVDATCHNAFIQEQSLGIHYNKDSDILDYITNKEVFEFKDGYV
                     DIPKKPGLGVEIDEAHVRKMAEVGHDWHNPIWRHKDGSIAEW"
     PFAM_domain     complement(8250..8930)
                     /aSDomain="MR_MLE_C"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF13378.8"
                     /description="Enolase C-terminal domain-like"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_1795_0033"
                     /evalue="1.30E-61"
                     /label="ctg1_1795"
                     /locus_tag="ctg1_1795"
                     /protein_end="355"
                     /protein_start="128"
                     /score="208.1"
                     /tool="antismash"
                     /translation="ANAAKKAFENGFEAIKMNATEELQYIDSYDKIESVVQRVAGIREA
                     VGNQLGIGIDFHGRVHKPMAKVLAKELEPYNPMFIEEPVLSENIEAVREISQTTTIPIA
                     LGERLFSRWDFKPILESGFVDIIQPDLSHAGGITECKKIISMGEAYDVGAAPHCPLGPI
                     ALASCLQVDATCHNAFIQEQSLGIHYNKDSDILDYITNKEVFEFKDGYVDIPKKPGLGV
                     EIDEA"
     PFAM_domain     complement(8994..9269)
                     /aSDomain="MR_MLE_N"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF02746.18"
                     /description="Mandelate racemase / muconate lactonizing
                     enzyme, N-terminal domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_1795_0032"
                     /evalue="4.30E-25"
                     /label="ctg1_1795"
                     /locus_tag="ctg1_1795"
                     /protein_end="107"
                     /protein_start="15"
                     /score="88.3"
                     /tool="antismash"
                     /translation="LFLKITTDEGIVGWGEPVIEGKAQTVGAAVDEFMQQLIGKNPLNI
                     EDHWNMMYRSSFYRGGPILMSAISGIDQALWDIKGKYYNAPVHELLG"
     CDS             complement(9329..9829)
                     /locus_tag="ctg1_1796"
                     /transl_table=11
                     /translation="MNSPKALESIELISNEMKGKVVVGAGTVLDAESARLAILSGATFI
                     LSPTVDKDTIRMSKKYGTVSIPGAMTPTEILEAYEYGGDIIKVFPTTSLGPEYIKDLQG
                     PLPHIPLLPTGGVSIDNVTDFIEAGAVGVGLGSALVNTKVETNKAYFEELEQKAQAFYN
                     KVH"
     PFAM_domain     complement(9392..9826)
                     /aSDomain="Aldolase"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF01081.21"
                     /description="KDPG and KHG aldolase"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_1796_0034"
                     /evalue="3.20E-31"
                     /label="ctg1_1796"
                     /locus_tag="ctg1_1796"
                     /protein_end="146"
                     /protein_start="1"
                     /score="108.4"
                     /tool="antismash"
                     /translation="NSPKALESIELISNEMKGKVVVGAGTVLDAESARLAILSGATFIL
                     SPTVDKDTIRMSKKYGTVSIPGAMTPTEILEAYEYGGDIIKVFPTTSLGPEYIKDLQGP
                     LPHIPLLPTGGVSIDNVTDFIEAGAVGVGLGSALVNTKVET"
ORIGIN
        1 tataaaacac tttttataat caaatatata cctaagatta acattgtaaa tcttaaaatt
       61 aaaacgacag tgtctgactt cattctacta tttattctta caccaatttt tgcaccaaag
      121 taacttgaaa taatcaatac aatcgcatgt acccaaagta cattaccttg cacaatgtgg
      181 ctgacagaac ttgataaact tgagaagaat atcatcatca tacttgtacc aacagcaaca
      241 tgtggtggga atctaaatac aataatcatt aaaggtgtca tcagtgcacc cccaccgata
      301 ccgaataaac cagtcgttat accaacaata aatgatgaaa caatagcgac aaacggtgga
      361 acaccgtatt tatgatgttc accatatcta tctgtaaatg attttaaata cttttctcgt
      421 tggaagtact ttattggttt cacatgatta cgtatcatta atacgataga aataaagatt
      481 aagaaaatac caaagtacaa attaaatgaa tctaaagtaa aatacttact taaatatgca
      541 ccaagtaaag cccctggaat aataccaatc aagaatatta atccattttt tacatcaact
      601 tgcttcgttt tcaaatagcc taatgttgct gttaaacccg ttgtaattaa tataacagat
      661 gatgtaccaa tcgctctttg tggtgtcata ccagacaata attgatggtc tataccaaag
      721 tatacgagtg aaggaacaat aataattccg ccaccaattc caactagcgc ccctaatatt
      781 gcagacgata cacctataat aattaacact aaatatgcca tacctgtcac ctctaaaata
      841 atttaagttg cttaggcgct aaaccttcgt attctatatc taataacttt tggtaagttt
      901 tggcattttg tgcagcatgt ccaccagaat tattattaaa tactacataa acatctttcg
      961 ctttatgctc taaaatttta actttatcag ctaactcttt aagttctgct tcattataat
     1021 tatataaata tctgacatca cgccactctt gatctgtcat atctttcttc gtccatccgt
     1081 ttacatttct accatggtaa cggacgaaag caacatcatg cgtaatacga tttataagtg
     1141 gtatagaccc ttctccactc tgcggttcat cacaaacgct atgaataaat ttcatttcgg
     1201 ttaaaaattc caacgtatac tctttaacat cttctttaaa ccaagtacga ttacggaatt
     1261 cgatacaaac atcaaaatct tttaattgct cacgtacata acgtaaataa ttaatatttt
     1321 gaggttgtaa atcaaaccaa ggtggaaact gtacgagaat catcgctaac tttcctgatg
     1381 cttttaacgg tgccatcgaa tctttaaata aattaaacaa tgtcattttg tcttcagcaa
     1441 aatcagttat ctcagcatga cctgttaacg cctgatgaat cttaacaaca aacttaaaat
     1501 tattaggcgt ttcccgaatc catttttcaa tatttcgttg cggttgaatc gcataataag
     1561 ttgcatctaa ttccacaata ggaaaatgag cagcatatgc ttttaactta tcttttttat
     1621 tagacaggtc ttcatataaa gaatcatgat ctccccatcc agttaggcca atttttatca
     1681 tatctcatca ccatactcat cataccacac agagtattta tagttcagtt tgtttgatta
     1741 aaattatgta aaactatgaa tgagcagtaa agaattgtat gtcgttcgtt acacttctta
     1801 tgcgttttgt aattataggc tgccttagtt acacttcgta cgatttttgt tactatggac
     1861 ctccttagtt acacttccta cgacttttgt tactaaatcc accattcttt tcaactcata
     1921 aaaaataacg gcaatgacaa ataataatgt cctagccgtt ttatatgtgt atcaactcat
     1981 tcatgtagca agttgtatat ttctatcaca atatttcata acttcctcgt catgcgtaac
     2041 aattaatata gtagatttac ctttaaattc tgataaaagt tcaagtattt tatatttatt
     2101 atcattgtct aaagcacctg ttggctcatc tgcaaaaatt attagaggtt cttttaatag
     2161 taacctagca attgcgactc tttgttgttc tcctccgctt aacgtataaa tcttagtatt
     2221 aagtggttta tttaatccta cttttttcat gacatcattt ttcaatactt ttttctgaga
     2281 tttactcaat tttttataag ttagtacgat gtccaaatta tgttcaatcg tttcatgtgt
     2341 gataagtgcg tagttttgaa acaaatagcc taacttattt cgatacaata gcatcttatg
     2401 tttacgtttc atcttagtta tgtcatcacc atcaatataa atagtaccac catcattttt
     2461 ttctaagcca cacatacaac ccaataaagt agattttccc gaaccacttc tcccagttat
     2521 ggcgaccatt tcacctttgt taatattcaa actcaaatca ctaaataaat taacaccatt
     2581 aaattgtttt cttaaattat ttaaacggat cattgtttaa tcatcttctc atactcagat
     2641 ttactaatat attctataaa ataaacccat ttacctttgt gatcgatttt gacatattgt
     2701 tcagaaggac tatgaccttt aaagtccaat aagtagttat ttttatgacc attttcatca
     2761 taagattcaa tatctttata atcttggata tttataattt cttgcttact taaatgttca
     2821 gcatcgctac tgtatggaac cttagcataa ctccaacctc ttttaacaaa gggatttact
     2881 acatccaatt tttcatcaat atttttcatc gtaaataaaa ttatacaaat tatcataatg
     2941 cttgctatta atgtataaat taactttttc attattgagt ctcacctctt cttgcatctt
     3001 tcaacaaatg atattcatat cgattaataa aaatcatgac agtaagtaat tcgaatagaa
     3061 taattgaaat cattaatttg aatgaaattt ctacaatatc aaaaaaattc acaataaata
     3121 atgctataaa agtagaaact aaactattta tcacaaaact tatatgcttt ttaaaaaaag
     3181 aatctccatg aatagttctt acaaatatca cttttttctc tttatcacaa taaatattaa
     3241 taataaatag atatactgaa attaatatta tgattcctag tatagaggta gtaacagaaa
     3301 caaatagatt acgttttatt ttattatatt cagtcaatac actactataa gcattagtca
     3361 aaccttgaat ttctgtatca aacttattat tatctagttt acttttaatt agatcataat
     3421 cattaaagag caataaccct tgtgatgtag cagaactata gaaagaaatt ggataataac
     3481 ctttaggtaa tattattatt actggattat aagatataac ctctttacta tatacacctg
     3541 tactatagtt aaataaatta taattatttt ttattttatg aactttgata tctagatacc
     3601 tttgtttatt aggaactttc tcaatttcat cataaaattc aatctcttct tgtaaatctt
     3661 cttttatttt atttatattc tctttggaaa atcctttatc aggaattagt gctgtaattt
     3721 ttgaaaaatc tactgattct ttgttttcta tactaatttt atttctatca ataaaagtct
     3781 tatttacata gatagcatta tctaaatcat atttctcccc agattttttc caattataat
     3841 gtctatgaaa tgtaagcatc caattctttt caggaatttt gtttaataaa tttatcactt
     3901 cttgatctga atatttaaac tgtttcttac ttgtttctat ttcatttgtt gtcaattcag
     3961 caatatataa atctttattc ttaaaccaat gcttttcact gttcacaatg tcaaacgctt
     4021 ctatgtagtt atgtattgaa atcgatataa cattgagtaa agttaaagtt actattaact
     4081 taattatatt tggcaagtat tgaaacctat tgccgacacc ttcaaatttt atatattttt
     4141 gaatattaaa agtttgttta gatactagcc agtaagacat tagcgatacc ataatcaaaa
     4201 taatataaaa aattactaca caaattaaat atgaccaaaa aatatatcta atttgtgcca
     4261 attgattata taaatataat ccaatagtta ctattaaagt tattattatg aaatgtgaaa
     4321 caaagatttt tgtaattttt aataattgta aagctataat ttttgccgat gtgaatccat
     4381 gtattcgttt aatagacatt tctttcactg aagcaagttg atcatataaa atagctatga
     4441 aaattattac taataaaatt atgaaagtag aaggtaattg atgggtactt atatattcca
     4501 atattattaa atgtaatgga aattcataat ctttagtagt taaacctttt tcttctaatg
     4561 tttcataaaa atcactcttg ggattctctt ttataaaaaa agttgttcca accaaattta
     4621 atttacccaa aattttatta tctggtttta taatttgata tttcttgtta cgattaaatg
     4681 ctttttcatt aaaattaagt ttctcgttca aattatattg agataaatat ttagttttac
     4741 cattatcatc ataattccca tttactcgaa tcatcgaaat attatgttca gtagaaagct
     4801 taactaataa cctatttatt tcttctttat tatgtttctt gtcccacttt tctatgacta
     4861 atgccttgtt gtatcctggc aatttaatat catctatata attataaaaa tttaagaata
     4921 taaaagttat aatacagaat ataagaaata tagttatctt tgtaattttc ttcatttaat
     4981 agcctcatta ataaaattca ttaatagaag ccgtaatatg ctttatttac tttccaaatt
     5041 tgccaacctg gtcgtttttg agccgatacc ttagaccatc ttcctttagg tgtataacct
     5101 gaagtagccc aataacgccc tcttacactc gtataatgtg ttttctttcc atggtaataa
     5161 ttagaccata catattgact tgaaacacca taattccatg taccaccatc aacattaact
     5221 tggtatgctt taacaatccc tgcaccagaa gcaattataa ttgttaataa taatgttata
     5281 aaaaattttt tcattaataa acactcccat ttttcaaaat tcaagacgtc ttaagaataa
     5341 tatatttaat tcataatatt ctgtcaatta ctttttatac aattttttac atttaaaacc
     5401 ctcgctattt gtttgttgat agcgagggtt ttgtgttata tttaatttat tcggatacct
     5461 tacataattt tatttaatga tggccgtcat tgtataattt ttatggttaa ggtatttttt
     5521 tctgcgtttt tattcattat tttgtctcct attttaattt caatacttgt ccgatttgta
     5581 tgacatctga tgttaatccg ttcaatttct ttaatgttgc tacggtaacg cctgtttttt
     5641 gactgatact ccatagtgta tctccggcta cgactgtata ggttgttgga ttcgtattga
     5701 tggctcctcc attgatggct tctgctagtg attttgtata tgcatttaaa ttatttttaa
     5761 tgtaattcat atcttttgtt gaggtaataa atcctaactc tactaatcga taattgatat
     5821 attctgcttt agctacgtta caatgtaata ggtcacttct ttctgtaatg cctctaatag
     5881 tacctacatg ttttttcacg gctgcttgta atgctttatc aatactgtct gctgctaatc
     5941 cacttggaat aataacatga cctcctgtag ctgatgcggc tgctgaatct aaatgaaatt
     6001 ctactacaat ttcataacct tgtgatttaa cccagtataa tccgtaatct tttttatttc
     6061 cgacctgatc accgtatgct gtatcttgat acatatcttg gtctttgccg tatactgcaa
     6121 ctttatggcc tgcttgtttt aaataatttg ctactctgtc tacgatattc gttctaataa
     6181 aatctctttc atttgttcca tttcctactg cgcctggatc attatacccg tgccctgcta
     6241 caatcataat ttttctactc attttaacgg ctcctttatt gttagattga tctaattttt
     6301 gattgagttt ggatatgtca taattttcaa ttggcatacc actacacact cttgttactt
     6361 ctttagaaat gtcttcacct ttttgacgta attggatatg caaatgttca ctcatcggat
     6421 tattgtcata attactattg ccttgtaatc caataatgtc accttgaatg actttatcac
     6481 ctttagaaaa ttgcaatgta tctctttgca tatgcccgta aatccaatca ttgccattat
     6541 tatctctaat ttcaattgtg cctccgaaat taccaaatgg ttcacttaat ataactgttc
     6601 cactagtaac tgctggaatt tgattcgttt cattactata gacatcaaat gctctatgat
     6661 aaccactaca ataggcatca taatttatgc catcttctgt gtaatttcta tatccatagt
     6721 tttttggata ttgatcgtac gttcttgggt ctgatgaaat ttcccatcct tttttagtta
     6781 aatatgttat agctgttaac attcaatcat cctttctcat ttttattttt taccagattg
     6841 ttttaagaac ttttcttgtt cacgtgattg atttgtaaaa atgaatgtgt ttttccaaat
     6901 accataaagc acaaatacaa taggtatccc tgtgtttaat acgttcatcc atgcatttaa
     6961 cttttgaggg ttcaaccatt ctaccgaaaa accagatgca ttcaatgcta aatatagtgc
     7021 acctaagaac ccacctatca ttgcgataaa ttgtttaact ttgtctggtt caattgggat
     7081 tctgttatct tcttcggaat aattcaaatt cactttatct gttttgaagt tcattttaac
     7141 catgtgtatc acctccttgg ttacactata atataacttt cggttgacgt caataacttt
     7201 tagttatatt tttctgcaaa attattgata aaatataact ataggttata ataatagtat
     7261 caatcatata aggagcggga aacttatggt gtctcaaaat aaactctctg aacaaataag
     7321 tttattaaga acgaaaaatg gatggacgca acaaaaatta gcagatgcgt tacaagtttc
     7381 aaaacaatcc atttcatatt gggaaacagg aagaaaagca ccaaagatga agaaaataga
     7441 agaaatggca aagttatttg atgtaagtgt cagttatatt ttagacgggg aagctaaaca
     7501 aacttataac tctactgcag aaacgattgc cgcacattta gatggagaat taacagaaga
     7561 agaattgaag aaagtattag aatatgttga ttttctaaag catcaaaaca aatgatttat
     7621 taaacggaaa atatggtggg gataatttga atagatatga aaaaacactt atcaataatg
     7681 aacacatcgt gattaaagaa acaagtaacc ttccgaatca actgaaaggt ttatatgtag
     7741 atggattaat tttattgaaa gatgatttat ctaacaaaga aaagttagaa gtgctaggag
     7801 aagagttagc ccatcatgat atatcttatg gagatattct cgatacaagt gaattatgga
     7861 aatggaaatt tgagcataaa gcaagaagat taggatttga aaaaattata cctctaaaaa
     7921 gtattgtgca agcgtaccaa tcaggcgtcc ataataaatt tgaactgagt aattatttag
     7981 acgtatctga agggtatata gatgaagctt tagaacatta caaacaaaaa tatggattaa
     8041 gcacatggta tgatcattat ttaataaagt tcaacccact tcaagtttat gaatatagag
     8101 aaatcaatta aaggctgaga cgtcattgtc tcagccttta atcatgttat gcacaaacgt
     8161 tatatttacc attctgcaat gcttccatct ttatgtctcc aaattgggtt atgccaatca
     8221 tgcccgactt ccgccatttt tctaacatgt gcttcatcaa tttctacacc aaggccaggc
     8281 tttttaggaa tatctacata tccatcttta aactcaaata cttctttgtt cgtaatataa
     8341 tctagaatat cactgtcttt attataatga atgcctaagc tttgttcttg tataaaagca
     8401 ttgtgacaag ttgcatccac ttgtaaacat gatgctaaag caataggtcc aagtggacaa
     8461 tgaggtgcag cacctacatc ataagcttct cccatagaaa taattttttt acattccgtt
     8521 ataccaccag catgtgataa atcaggttga atgatatcga caaatccact ttctaaaata
     8581 ggtttgaaat cccatctaga aaatagcctt tcaccaagcg ctattggaat agttgtcgtt
     8641 tgactaattt ctctaaccgc ttctatattt tcacttaata caggttcttc tataaacatt
     8701 ggattgtatg gctctaattc tttagctaat actttagcca ttggtttatg aacacgcccg
     8761 tgaaaatcaa ttccaatacc taactgattg ccaaccgctt ctctaatacc agcaacacgt
     8821 tgaacaacac tttctatctt gtcataacta tctatatact gtaattcttc agttgcattc
     8881 attttgattg cttcaaaacc attttcaaaa gcttttttag cagcgtttgc agtatcttga
     8941 ggtctatcac caccaaccca tgaatatact ttcatagatt ctctacatgc cccacctaat
     9001 aattcatgaa caggcgcgtt gtaatattta cctttaatat cccacaatgc ttggtctata
     9061 cctgaaatgg cactcattaa aattggacca cctctataaa agctacttct atacatcatg
     9121 ttccaatgat cttcaatatt taaaggattt ttgccaatca actgctgcat aaattcatca
     9181 accgctgcac caacagtctg agctttacct tcaattacag gttcgcccca tccgacgata
     9241 ccttcatccg ttgtaatttt tagaaacaac caacgcggtg gtacttgaaa caactcatag
     9301 tctacaatct tcatgttagc actcctcttt aatgtacttt gttataaaat gcttgtgctt
     9361 tttgttctag ttcctcaaaa tacgctttat tcgtttctac tttcgtattt actaaagcac
     9421 ttcctaaacc gacgccaaca gctcccgctt caataaagtc tgtaacattg tctatactta
     9481 caccacctgt tggtaaaagt gggatatgcg gtagtggacc ttgtaaatct ttaatatatt
     9541 caggacctaa acttgttgtt ggaaagactt taataatatc tccaccgtat tcataagctt
     9601 ctagaatttc tgttggtgtc atagcacctg gtatacttac ggtaccatat tttttactca
     9661 tgcgaatcgt atctttatct accgttggcg acagtataaa cgttgcacca cttaaaatag
     9721 ctaaccttgc cgattccgca tctaagactg tacctgctcc gactacaact tttcccttca
     9781 tttcattaga gatcagttca atagattcta acgctttagg tgaattcatc gtaacctcta
     9841 tcgcacgaat acctgcttta tataatgttt ctacgattgg taaaatatca ttgggatttg
     9901 catttcgtaa aattgcgatt aatttagttt ctttgattgt ttgtaatgta tctattttag
     9961 acgcctcctt atctaatcac atcatctaca tgacctgtat gtttcatttg ttcaatttct
    10021 tctttagttg gtaagccttc aacatcccct ttaaccgttg tcacgagtgc tcctgcattg
    10081 caagcttgtt ctgatgcttc atgaatggat aatccttcga taatacctgc aattaaacct
    10141 gccgcaaagc catctccagc accaacagga tcaacgactt ctatttcttt tgaagctttt
    10201 gcataacctg aaatatcttc atgtacatag taagcacctt tacttcctaa tttaacaact
    10261 actgttgatg cacctaaatt tataatcttt tgag
//
