GCF_000295095.1_ASM29509v1_genomic - 3 region(s)

Identified secondary metabolite regions using strictness 'relaxed'

NZ_JH806632.1

Region	Type	From	To	Most similar known cluster		Similarity
Region 1.1	thiopeptide	1,094,324	1,121,785
Region 1.2	thiopeptide	1,193,498	1,223,329	berninamycin A	RiPP	13%

NZ_JH806633.1

Region	Type	From	To	Most similar known cluster		Similarity
Region 2.1	transAT-PKS,NRPS-like	601,794	733,997	BE-7585A	Polyketide	19%

Region	Type	From	To	Most similar known cluster	Similarity
Region 1.1	thiopeptide	1,094,324	1,121,785
Region 1.2	thiopeptide	1,193,498	1,223,329	berninamycin A	RiPP	13%
Region 2.1	transAT-PKS,NRPS-like	601,794	733,997	BE-7585A	Polyketide	19%

No secondary metabolite regions were found in these records:: NZ_JH806634.1; NZ_JH806635.1

Compact view

NZ_JH806632.1 - Region 1 - thiopeptide

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Location: 1,094,324 - 1,121,785 nt. (total: 27,462 nt) Show pHMM detection rules used

thiopeptide: ((YcaO or TIGR03882) and ((thio_amide and (PF06968 or PF04055 or PF07366)) or Lant_dehydr_C or Lant_dehydr_N or PF07366 or PF06968 or PF04055) or thiostrepton)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

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Gene details

Select a gene to view the details available for it

MIBiG comparison

KnownClusterBlast

Thiopeptides

Pfam domains

TIGRFAM domains

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000386.1	0.17	NRP	malleobactin A, malleobactin B, malleobactin C, malleobactin D	Burkholderia thailandensis E264
BGC0001472.1	0.13	RiPP	berninamycin A	Streptomyces bernensis
BGC0000565.1	0.12	RiPP	goadsporin	Streptomyces sp. TP-A0584
BGC0000615.1	0.11	RiPP	TP-1161	Nocardiopsis sp. TFS65-07
BGC0000471.1	0.11	RiPP	viridisamide A	Oscillatoria nigro-viridis PCC 7112
BGC0001753.1	0.10	RiPP	radamycin, globimycin	Streptomyces globisporus subsp. globisporus
BGC0000475.1	0.10	RiPP	patellamide A, patellamide C	Prochloron didemni
BGC0000474.1	0.10	RiPP	microcyclamide	Microcystis aeruginosa PCC 7806
BGC0000473.1	0.10	RiPP	microcyclamide	Microcystis aeruginosa NIES-298
BGC0000480.1	0.10	RiPP	tenuecyclamide A, tenuecyclamide C	Nostoc spongiaeforme var. tenue str. Carmeli

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000386.1	0.48	NRP	malleobactin A, malleobactin B, malleobactin C, malleobactin D	Burkholderia thailandensis E264
BGC0001472.1	0.41	RiPP	berninamycin A	Streptomyces bernensis
BGC0000565.1	0.40	RiPP	goadsporin	Streptomyces sp. TP-A0584
BGC0000615.1	0.38	RiPP	TP-1161	Nocardiopsis sp. TFS65-07
BGC0000471.1	0.38	RiPP	viridisamide A	Oscillatoria nigro-viridis PCC 7112
BGC0001753.1	0.35	RiPP	radamycin, globimycin	Streptomyces globisporus subsp. globisporus
BGC0000475.1	0.35	RiPP	patellamide A, patellamide C	Prochloron didemni
BGC0000474.1	0.35	RiPP	microcyclamide	Microcystis aeruginosa PCC 7806
BGC0000473.1	0.35	RiPP	microcyclamide	Microcystis aeruginosa NIES-298
BGC0000480.1	0.35	RiPP	tenuecyclamide A, tenuecyclamide C	Nostoc spongiaeforme var. tenue str. Carmeli

Similar known gene clusters

No matches found.

Thiopeptide predictions

No core peptides found.

Detailed Pfam domain annotation

Selected features only

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Detailed TIGRFAM domain annotation

Selected features only

Expand to show all names

Thiopeptides

Core peptide predictions

No core peptides found.

NZ_JH806632.1 - Region 2 - thiopeptide

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Location: 1,193,498 - 1,223,329 nt. (total: 29,832 nt) Show pHMM detection rules used

thiopeptide: ((YcaO or TIGR03882) and ((thio_amide and (PF06968 or PF04055 or PF07366)) or Lant_dehydr_C or Lant_dehydr_N or PF07366 or PF06968 or PF04055) or thiostrepton)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

MIBiG comparison

KnownClusterBlast

Thiopeptides

Pfam domains

TIGRFAM domains

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000896.1	0.17	Other	cycloserine	Streptomyces lavendulae subsp. lavendulae
BGC0000556.1	0.16	RiPP	streptin	Streptococcus pyogenes
BGC0000506.1	0.16	RiPP	entianin	Bacillus subtilis subsp. spizizenii
BGC0000515.1	0.16	RiPP	geobacillin I	Geobacillus thermodenitrificans NG80-2
BGC0001173.1	0.16	RiPP	plantazolicin	Bacillus pumilus ATCC 7061
BGC0000569.1	0.16	RiPP	plantazolicin	Bacillus velezensis FZB42
BGC0000528.1	0.16	RiPP	michiganin A	Clavibacter michiganensis subsp. michiganensis NCPPB 382
BGC0001374.1	0.16	Other	thienodolin	Streptomyces albogriseolus
BGC0000537.1	0.16	RiPP	nisin U	Streptococcus uberis
BGC0000616.1	0.16	RiPP	amylocyclicin	Bacillus velezensis FZB42

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000896.1	0.48	Other	cycloserine	Streptomyces lavendulae subsp. lavendulae
BGC0000556.1	0.47	RiPP	streptin	Streptococcus pyogenes
BGC0000506.1	0.47	RiPP	entianin	Bacillus subtilis subsp. spizizenii
BGC0000515.1	0.47	RiPP	geobacillin I	Geobacillus thermodenitrificans NG80-2
BGC0001173.1	0.47	RiPP	plantazolicin	Bacillus pumilus ATCC 7061
BGC0000569.1	0.47	RiPP	plantazolicin	Bacillus velezensis FZB42
BGC0000528.1	0.47	RiPP	michiganin A	Clavibacter michiganensis subsp. michiganensis NCPPB 382
BGC0001374.1	0.46	Other	thienodolin	Streptomyces albogriseolus
BGC0000537.1	0.46	RiPP	nisin U	Streptococcus uberis
BGC0000616.1	0.46	RiPP	amylocyclicin	Bacillus velezensis FZB42

Similar known gene clusters

Thiopeptide predictions

No core peptides found.

Detailed Pfam domain annotation

Selected features only

Expand to show all names

Detailed TIGRFAM domain annotation

Selected features only

Expand to show all names

Thiopeptides

Core peptide predictions

No core peptides found.

NZ_JH806633.1 - Region 1 - NRPS-like,transAT-PKS

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Location: 601,794 - 733,997 nt. (total: 132,204 nt) Show pHMM detection rules used

transAT-PKS: (cds(PKS_AT and not (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS)) and (cds(ATd and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS)) or cds(tra_KS and PP-binding)))
NRPS-like: cds((PP-binding or NAD_binding_4) and (AMP-binding or A-OX))

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

Pfam domains

TIGRFAM domains

Detailed domain annotation

Selected features only

Show module domains

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001909.1	0.64	Polyketide	strobilurin	Strobilurus tenacellus
BGC0001264.1	0.53	Polyketide	betaenone A, betaenone B, betaenone C	Phoma betae
BGC0001280.1	0.53	Polyketide	betaenone C, betaenone A	Phoma betae
BGC0000041.1	0.45	Polyketide	oronofacic acid	Pseudomonas syringae
BGC0001606.1	0.44	Polyketide	gibepyrone-A	Fusarium fujikuroi IMI 58289
BGC0000046.1	0.44	Polyketide	depudecin	Alternaria brassicicola
BGC0001124.1	0.44	Polyketide	pyranonigrin E	Aspergillus niger ATCC 1015
BGC0001340.1	0.44	Polyketide	byssochlamic acid	Byssochlamys fulva
BGC0001276.1	0.44	Polyketide	6-methylsalicyclic acid	Aspergillus terreus
BGC0001254.1	0.44	Polyketide	ACT-Toxin II	Alternaria alternata

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001909.1	0.66	Polyketide	strobilurin	Strobilurus tenacellus
BGC0001730.1	0.62	Polyketide	paramagnetoquinone 1, paramagnetoquinone 2	Actinoallomurus sp.
BGC0001264.1	0.60	Polyketide	betaenone A, betaenone B, betaenone C	Phoma betae
BGC0001280.1	0.60	Polyketide	betaenone C, betaenone A	Phoma betae
BGC0002008.1	0.60	Other	aryl polyenes	Xenorhabdus doucetiae
BGC0000836.1	0.60	Other	APE Ec	Escherichia coli CFT073
BGC0000041.1	0.60	Polyketide	oronofacic acid	Pseudomonas syringae
BGC0002010.1	0.59	NRP, Polyketide	streptophenazine B, streptophenazine C, streptophenazine F, streptophenazine G, streptophenazine H	Streptomyces sp. CNB091
BGC0000837.1	0.59	Other	APE Vf	Aliivibrio fischeri ES114
BGC0000220.1	0.57	Polyketide	enterocin	Streptomyces maritimus

Similar known gene clusters

Module view

Legend

Detailed Pfam domain annotation

Selected features only

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Detailed TIGRFAM domain annotation

Selected features only

Expand to show all names

NRPS/PKS products

NRPS/PKS monomers

Predicted core structure(s)

For candidate cluster 1, location 601793 - 733997:

Rough prediction of core scaffold based on assumed PKS linker matching; tailoring reactions not taken into account

Polymer prediction:: (ccmal - mal - mal - mal) + (mal - ccmal - ccmal) + (ccmal - ccmal)
Non-colinear ordering:: ctg2_577 + ctg2_542 + ctg2_575 + ctg2_543 + ctg2_582 + ctg2_580 + ctg2_583 + ctg2_584 + ctg2_573 + ctg2_574 + ctg2_572

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS monomer predictions

ctg2_543

PKS_AT (62..403): mxmal

ATSignature: (unknown)

No matches above 50%

minowa: Methoxymalonyl-CoA

Prediction, score:

Methoxymalonyl-CoA: 12.2
Benzoyl-CoA: 11.6
2-Methylbutyryl-CoA: 11.4
Methylmalonyl-CoA: 7.9
Propionyl-CoA: 7.7
CHC-CoA: 7.5
Malonyl-CoA: 1.5
trans-1,2-CPDA: 0.0
inactive: 0.0
fatty_acid: 0.0
Isobutyryl-CoA: 0.0
Acetyl-CoA: 0.0
3-Methylbutyryl-CoA: 0.0
Ethylmalonyl-CoA: -0.6

PKS_AT (1412..1670): mal

ATSignature: (unknown)

No matches above 50%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 30.6
Methoxymalonyl-CoA: 18.2
inactive: 12.9
Methylmalonyl-CoA: 12.2
trans-1,2-CPDA: 0.0
fatty_acid: 0.0
Propionyl-CoA: 0.0
Isobutyryl-CoA: 0.0
Ethylmalonyl-CoA: 0.0
CHC-CoA: 0.0
Benzoyl-CoA: 0.0
Acetyl-CoA: 0.0
3-Methylbutyryl-CoA: 0.0
2-Methylbutyryl-CoA: 0.0

ctg2_577

CAL_domain (44..461): pk

minowa: Acetyl-CoA

Prediction, score:

Acetyl-CoA: 27.5
NH2: 8.7
AHBA: 3.9
shikimic_acid: 0.0
fatty_acid: 0.0

ctg2_582

PKS_AT (4..277): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 75.0%; inactive: 62.5%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 122.8
Methoxymalonyl-CoA: 49.5
inactive: 39.3
Propionyl-CoA: 36.8
Methylmalonyl-CoA: 34.7
Benzoyl-CoA: 11.3
2-Methylbutyryl-CoA: 11.0
Isobutyryl-CoA: 7.6
trans-1,2-CPDA: 0.0
fatty_acid: 0.0
Ethylmalonyl-CoA: 0.0
CHC-CoA: 0.0
Acetyl-CoA: 0.0
3-Methylbutyryl-CoA: 0.0

ctg2_584

PKS_AT (7..280): mxmal

ATSignature: (unknown)

No matches above 50%

minowa: Methoxymalonyl-CoA

Prediction, score:

Methoxymalonyl-CoA: 25.3
Propionyl-CoA: 10.6
Isobutyryl-CoA: 10.6
fatty_acid: 10.0
Malonyl-CoA: 5.6
trans-1,2-CPDA: 0.0
inactive: 0.0
Methylmalonyl-CoA: 0.0
Ethylmalonyl-CoA: 0.0
CHC-CoA: 0.0
Benzoyl-CoA: 0.0
Acetyl-CoA: 0.0
3-Methylbutyryl-CoA: 0.0
2-Methylbutyryl-CoA: 0.0