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Overview
1.1
1.2
1.3
1.4

### Identified secondary metabolite regions using strictness 'relaxed'

NZ_CP035288.1

Region | Type | From | To | Most similar known cluster | Similarity
--- | --- | --- | --- | --- | ---
Region 1.1 | NRPS | 226,771 | 273,934 |
Region 1.2 | T3PKS | 445,930 | 487,096 |
Region 1.3 | siderophore | 783,633 | 798,625 | staphyloferrin A | Other:Non-NRP siderophore | 100%
Region 1.4 | cyclic-lactone-autoinducer | 919,783 | 940,491 |

Region | Type | From | To | Most similar known cluster | Similarity
--- | --- | --- | --- | --- | ---
Region 1.1 | NRPS | 226,771 | 273,934 |
Region 1.2 | T3PKS | 445,930 | 487,096 |
Region 1.3 | siderophore | 783,633 | 798,625 | staphyloferrin A | Other:Non-NRP siderophore | 100%
Region 1.4 | cyclic-lactone-autoinducer | 919,783 | 940,491 |

No secondary metabolite regions were found in these records:
  NZ_CP035289.1
  NZ_CP035290.1

Compact view
NZ_CP035288.1 - Region 1 - NRPS
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 226,771 - 273,934 nt. (total: 47,164 nt) Show pHMM detection rules used
NRPS: cds(Condensation and (AMP-binding or A-OX))

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
NRPS/PKS domains
MIBiG comparison
KnownClusterBlast
NRPS/PKS modules
Pfam domains
TIGRFAM domains
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
A glossary is available here.
Selected features only
Show module domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | NRPS | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000308.1 |  | 0.51 | NRP | aureusimine | Staphylococcus aureus subsp. aureus str. JKD6008
BGC0001479.1 |  | 0.27 | NRP | anabaenopeptin NZ857, nostamide A | Nostoc punctiforme PCC 73102
BGC0001132.1 |  | 0.23 | NRP | xenotetrapeptide | Xenorhabdus nematophila ATCC 19061
BGC0001128.1 |  | 0.23 | NRP | luminmide | Photorhabdus laumondii subsp. laumondii TTO1
BGC0001135.1 |  | 0.22 | NRP | bicornutin A1, bicornutin A2 | Xenorhabdus budapestensis
BGC0001641.1 |  | 0.22 | NRP | kolossin | Photorhabdus laumondii subsp. laumondii TTO1
BGC0001636.1 |  | 0.21 | NRP | KK-1 | Curvularia clavata
BGC0001825.1 |  | 0.21 | NRP | xenematide | Xenorhabdus nematophila AN6/1
BGC0001844.1 |  | 0.21 | NRP | holrhizin | Paraburkholderia rhizoxinica HKI 454
BGC0000307.1 |  | 0.21 | NRP | AbT1 | Aureobasidium pullulans

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000308.1 |  | 0.79 | NRP | aureusimine | Staphylococcus aureus subsp. aureus str. JKD6008
BGC0001479.1 |  | 0.61 | NRP | anabaenopeptin NZ857, nostamide A | Nostoc punctiforme PCC 73102
BGC0001132.1 |  | 0.57 | NRP | xenotetrapeptide | Xenorhabdus nematophila ATCC 19061
BGC0001128.1 |  | 0.56 | NRP | luminmide | Photorhabdus laumondii subsp. laumondii TTO1
BGC0001135.1 |  | 0.55 | NRP | bicornutin A1, bicornutin A2 | Xenorhabdus budapestensis
BGC0001641.1 |  | 0.55 | NRP | kolossin | Photorhabdus laumondii subsp. laumondii TTO1
BGC0001636.1 |  | 0.54 | NRP | KK-1 | Curvularia clavata
BGC0001825.1 |  | 0.54 | NRP | xenematide | Xenorhabdus nematophila AN6/1
BGC0001844.1 |  | 0.54 | NRP | holrhizin | Paraburkholderia rhizoxinica HKI 454
BGC0000307.1 |  | 0.54 | NRP | AbT1 | Aureobasidium pullulans

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.

No matches found.

Module view
Shows module structures for each candidate in NRPS- and PKS regions. Genes are shown in predicted order, and are only present when containing at least one complete module. A domain glossary is available here.
Legend
Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
NRPS/PKS products
NRPS/PKS monomers
Predicted core structure(s)
Shows estimated product structure and polymer for each candidate cluster in the region. To show the product, click on the expander or the candidate cluster feature drawn in the overview.
For candidate cluster 1, location 226770 - 273934:
Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:
  (val - X)

Direct lookup in NORINE database: strict or relaxed
Link to NORINE database query form
NRPS/PKS monomer predictions
Shows the predicted monomers for each adynelation domain and acyltransferase within genes. Each gene prediction can be expanded to view detailed predictions of each domain. Each prediction can be expanded to view the predictions by tool (and, for some tools, further expanded for extra details).

ctg1_225: val - X
  Search NORINE for peptide: strict or relaxed
  AMP-binding (427..817): val
  NRPSPredictor2: val
  SVM prediction details:
    Predicted physicochemical class:
      hydrophobic-aliphatic
    Large clusters prediction:
      gly, ala, val, leu, ile, abu, iva
    Small clusters prediction:
      val, leu, ile, abu, iva
    Single AA prediction:
      val
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DAfWLGGTFK
    Nearest Stachelhaus code:
      val
    Stachelhaus code match:
      90% (moderate)
  AMP-binding (1453..1833): X
  NRPSPredictor2: hydrophobic-aliphatic
  SVM prediction details:
    Predicted physicochemical class:
      hydrophobic-aliphatic
    Large clusters prediction:
      N/A
    Small clusters prediction:
      N/A
    Single AA prediction:
      N/A
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DAtSIGaViK
    Nearest Stachelhaus code:
      lys
    Stachelhaus code match:
      70% (weak)

NZ_CP035288.1 - Region 2 - T3PKS
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 445,930 - 487,096 nt. (total: 41,167 nt) Show pHMM detection rules used
T3PKS: (Chal_sti_synt_C or Chal_sti_synt_N)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
NRPS/PKS domains
MIBiG comparison
KnownClusterBlast
Pfam domains
TIGRFAM domains
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
A glossary is available here.
Selected features only
Show module domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | T3PKS | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000286.1 |  | 0.23 | Polyketide | viguiepinol | Streptomyces sp. KO-3988
BGC0001848.1 |  | 0.22 | Other | diazaquinomycin H, diazaquinomycin J | Micromonospora sp. B006
BGC0000679.1 |  | 0.22 | Terpene | diazepinomicin | Micromonospora sp. M42
BGC0001184.1 |  | 0.21 | Other | bacilysin | Bacillus velezensis FZB42
BGC0000218.1 |  | 0.16 | Polyketide | doxorubicin | Streptomyces peucetius
BGC0000509.1 |  | 0.16 | RiPP | epilancin 15x | Staphylococcus epidermidis
BGC0000205.1 |  | 0.16 | Polyketide | bryostatin | Candidatus Endobugula sertula
BGC0000922.1 |  | 0.16 | Other | pseudomonas quinolone signal (PQS) | Pseudomonas aeruginosa PAO1
BGC0001104.1 |  | 0.16 | NRP, Polyketide | myxovirescin A1 | Myxococcus xanthus DK 1622
BGC0000839.1 |  | 0.15 | Other | flexirubin | Chitinophaga pinensis DSM 2588

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000286.1 |  | 0.56 | Polyketide | viguiepinol | Streptomyces sp. KO-3988
BGC0001848.1 |  | 0.55 | Other | diazaquinomycin H, diazaquinomycin J | Micromonospora sp. B006
BGC0000679.1 |  | 0.54 | Terpene | diazepinomicin | Micromonospora sp. M42
BGC0001184.1 |  | 0.54 | Other | bacilysin | Bacillus velezensis FZB42
BGC0000218.1 |  | 0.47 | Polyketide | doxorubicin | Streptomyces peucetius
BGC0000509.1 |  | 0.47 | RiPP | epilancin 15x | Staphylococcus epidermidis
BGC0000205.1 |  | 0.46 | Polyketide | bryostatin | Candidatus Endobugula sertula
BGC0000922.1 |  | 0.46 | Other | pseudomonas quinolone signal (PQS) | Pseudomonas aeruginosa PAO1
BGC0001104.1 |  | 0.46 | NRP, Polyketide | myxovirescin A1 | Myxococcus xanthus DK 1622
BGC0000839.1 |  | 0.46 | Other | flexirubin | Chitinophaga pinensis DSM 2588

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.

No matches found.

Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
NZ_CP035288.1 - Region 3 - siderophore
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 783,633 - 798,625 nt. (total: 14,993 nt) Show pHMM detection rules used
siderophore: IucA_IucC

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
MIBiG comparison
KnownClusterBlast
Pfam domains
TIGRFAM domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | siderophore | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000944.1 |  | 0.56 | Other (Non-NRP siderophore) | staphyloferrin A | Staphylococcus aureus subsp. aureus NCTC 8325
BGC0001870.1 |  | 0.23 | Other | putrebactin, avaroferrin | Xenorhabdus budapestensis
BGC0000939.1 |  | 0.22 | Other | aerobactin | Grimontia hollisae
BGC0000947.1 |  | 0.19 | Other | vibrioferrin | Vibrio alginolyticus
BGC0000943.1 |  | 0.16 | Other | staphylobactin | Staphylococcus aureus subsp. aureus NCTC 8325
BGC0000883.1 |  | 0.15 | Other | arginomycin | Streptomyces arginensis
BGC0000666.1 |  | 0.14 | Terpene | xiamycin A | Streptomyces sp. SCSIO 02999
BGC0001767.1 |  | 0.10 | NRP | salinichelins | Salinispora pacifica CNY331
BGC0001211.1 |  | 0.10 | NRP | albachelin | Amycolatopsis alba DSM 44262
BGC0000423.1 |  | 0.10 | NRP | scabichelin | Streptomyces scabiei 87.22

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000944.1 |  | 0.82 | Other (Non-NRP siderophore) | staphyloferrin A | Staphylococcus aureus subsp. aureus NCTC 8325
BGC0001870.1 |  | 0.56 | Other | putrebactin, avaroferrin | Xenorhabdus budapestensis
BGC0000939.1 |  | 0.55 | Other | aerobactin | Grimontia hollisae
BGC0000947.1 |  | 0.51 | Other | vibrioferrin | Vibrio alginolyticus
BGC0000943.1 |  | 0.47 | Other | staphylobactin | Staphylococcus aureus subsp. aureus NCTC 8325
BGC0000883.1 |  | 0.45 | Other | arginomycin | Streptomyces arginensis
BGC0000666.1 |  | 0.43 | Terpene | xiamycin A | Streptomyces sp. SCSIO 02999
BGC0001767.1 |  | 0.36 | NRP | salinichelins | Salinispora pacifica CNY331
BGC0001211.1 |  | 0.36 | NRP | albachelin | Amycolatopsis alba DSM 44262
BGC0000423.1 |  | 0.35 | NRP | scabichelin | Streptomyces scabiei 87.22

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.
Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
NZ_CP035288.1 - Region 4 - cyclic-lactone-autoinducer
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 919,783 - 940,491 nt. (total: 20,709 nt) Show pHMM detection rules used
cyclic-lactone-autoinducer: (TIGR04223 or AgrB)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
MIBiG comparison
KnownClusterBlast
Pfam domains
TIGRFAM domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | cyclic-lactone-autoinducer | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000540.1 |  | 0.12 | RiPP | paenibacillin | Paenibacillus polymyxa OSY-DF
BGC0001687.1 |  | 0.11 | Other | N-tetradecanoyl tyrosine | uncultured bacterium CSL12
BGC0001872.1 |  | 0.08 | Polyketide | fabclavine-polyamine | Xenorhabdus bovienii SS-2004
BGC0000433.1 |  | 0.08 | NRP | surfactin | Bacillus velezensis FZB42
BGC0001053.1 |  | 0.07 | NRP, Polyketide | tubulysin A | Archangium disciforme
BGC0001836.1 |  | 0.07 | Polyketide | tartrolon D, tartrolon F, tartrolon G | Gynuella sunshinyii YC6258
BGC0001130.1 |  | 0.07 | NRP, Polyketide | fabclavine Ia | Xenorhabdus budapestensis
BGC0000082.1 |  | 0.04 | Polyketide | kijanimicin | Actinomadura kijaniata
BGC0000163.1 |  | 0.03 | Polyketide | tetronasin | Streptomyces longisporoflavus

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000540.1 |  | 0.41 | RiPP | paenibacillin | Paenibacillus polymyxa OSY-DF
BGC0001687.1 |  | 0.37 | Other | N-tetradecanoyl tyrosine | uncultured bacterium CSL12
BGC0001872.1 |  | 0.31 | Polyketide | fabclavine-polyamine | Xenorhabdus bovienii SS-2004
BGC0000433.1 |  | 0.30 | NRP | surfactin | Bacillus velezensis FZB42
BGC0001053.1 |  | 0.29 | NRP, Polyketide | tubulysin A | Archangium disciforme
BGC0001836.1 |  | 0.29 | Polyketide | tartrolon D, tartrolon F, tartrolon G | Gynuella sunshinyii YC6258
BGC0001130.1 |  | 0.27 | NRP, Polyketide | fabclavine Ia | Xenorhabdus budapestensis
BGC0000082.1 |  | 0.20 | Polyketide | kijanimicin | Actinomadura kijaniata
BGC0000163.1 |  | 0.17 | Polyketide | tetronasin | Streptomyces longisporoflavus

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.

No matches found.

Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names