GCF_000179635.2_ASM17963v2_genomic - 4 region(s)

Identified secondary metabolite regions using strictness 'relaxed'

NC_014833.1

Region	Type	From	To
Region 1.1	NRPS	950,621	1,029,899
Region 1.2	cyclic-lactone-autoinducer	1,754,537	1,775,363
Region 1.3	RRE-containing	1,972,671	1,992,738
Region 1.4	ranthipeptide	2,251,605	2,273,261

Region	Type	From	To	Similarity
Region 1.1	NRPS	950,621	1,029,899
Region 1.2	cyclic-lactone-autoinducer	1,754,537	1,775,363
Region 1.3	RRE-containing	1,972,671	1,992,738
Region 1.4	ranthipeptide	2,251,605	2,273,261

No secondary metabolite regions were found in these records:: NC_014824.1; NC_014825.1; NC_014826.1; NC_014827.1

Compact view

NC_014833.1 - Region 1 - NRPS

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Location: 950,621 - 1,029,899 nt. (total: 79,279 nt) Show pHMM detection rules used

NRPS: cds(Condensation and (AMP-binding or A-OX))

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

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Gene details

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NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

Pfam domains

TIGRFAM domains

Detailed domain annotation

Selected features only

Show module domains

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000427.1	0.33	NRP	shinorine, 4-deoxygadusol, mycosporine glycine	Trichormus variabilis ATCC 29413
BGC0001249.1	0.33	NRP	dimethylcoprogen	Alternaria alternata
BGC0000900.1	0.32	Other	ferrichrome	Aspergillus oryzae
BGC0000375.1	0.32	NRP	indigoidine	Streptomyces chromofuscus
BGC0000348.1	0.31	NRP	ergovaline	Epichloe festucae var. lolii
BGC0001479.1	0.29	NRP	anabaenopeptin NZ857, nostamide A	Nostoc punctiforme PCC 73102
BGC0001591.1	0.28	Other	fatty acid enol ester	uncultured bacterium CSLC2
BGC0001688.1	0.28	Other	N-tetradecanoyl tyrosine	uncultured bacterium CSLC2
BGC0001718.1	0.28	NRP	okaramine D	Aspergillus aculeatus ATCC 16872
BGC0000373.1	0.28	NRP	holomycin	Streptomyces clavuligerus ATCC 27064

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000427.1	0.67	NRP	shinorine, 4-deoxygadusol, mycosporine glycine	Trichormus variabilis ATCC 29413
BGC0001249.1	0.66	NRP	dimethylcoprogen	Alternaria alternata
BGC0000900.1	0.65	Other	ferrichrome	Aspergillus oryzae
BGC0000375.1	0.65	NRP	indigoidine	Streptomyces chromofuscus
BGC0000348.1	0.64	NRP	ergovaline	Epichloe festucae var. lolii
BGC0001479.1	0.62	NRP	anabaenopeptin NZ857, nostamide A	Nostoc punctiforme PCC 73102
BGC0001591.1	0.62	Other	fatty acid enol ester	uncultured bacterium CSLC2
BGC0001688.1	0.62	Other	N-tetradecanoyl tyrosine	uncultured bacterium CSLC2
BGC0001718.1	0.62	NRP	okaramine D	Aspergillus aculeatus ATCC 16872
BGC0000373.1	0.61	NRP	holomycin	Streptomyces clavuligerus ATCC 27064

Similar known gene clusters

No matches found.

Module view

Legend

Detailed Pfam domain annotation

Selected features only

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Detailed TIGRFAM domain annotation

Selected features only

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NRPS/PKS products

NRPS/PKS monomers

Predicted core structure(s)

For candidate cluster 1, location 950620 - 1029899:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (cys - cys) + (Me-mal) + (mal) + (leu) + (X) + (cys)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS monomer predictions

ctg1_881

Search NORINE for peptide: strict or relaxed

AMP-binding (20..424): pip

NRPSPredictor2: pip

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic
Large clusters prediction:: N/A
Small clusters prediction:: dhb, sal
Single AA prediction:: pip

Stachelhaus prediction details:

Stachelhaus sequence:: PwPAQGVitK
Nearest Stachelhaus code:: dhb
Stachelhaus code match:: 70% (weak)

ctg1_882

Search NORINE for peptide: strict or relaxed

AMP-binding (546..941): cys

NRPSPredictor2: cys

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic
Large clusters prediction:: cys
Small clusters prediction:: cys
Single AA prediction:: cys

Stachelhaus prediction details:

Stachelhaus sequence:: DLYNLSLIWK
Nearest Stachelhaus code:: cys
Stachelhaus code match:: 100% (strong)

AMP-binding (1608..1996): cys

NRPSPredictor2: cys

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic
Large clusters prediction:: cys
Small clusters prediction:: cys
Single AA prediction:: cys

Stachelhaus prediction details:

Stachelhaus sequence:: DLYNLSLIWK
Nearest Stachelhaus code:: cys
Stachelhaus code match:: 100% (strong)

ctg1_890

Search NORINE for peptide: strict or relaxed

AMP-binding (663..924): leu

NRPSPredictor2: leu

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic
Large clusters prediction:: gly, ala, val, leu, ile, abu, iva
Small clusters prediction:: val, leu, ile, abu, iva
Single AA prediction:: leu

Stachelhaus prediction details:

Stachelhaus sequence:: DAWFLGNVVK
Nearest Stachelhaus code:: leu
Stachelhaus code match:: 100% (strong)

ctg1_893

Search NORINE for peptide: strict or relaxed

AMP-binding (209..601): X

NRPSPredictor2: hydrophobic-aliphatic

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic
Large clusters prediction:: N/A
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: DAKnIGVsvK
Nearest Stachelhaus code:: glu
Stachelhaus code match:: 70% (weak)

ctg1_895

CAL_domain (296..587): pk

minowa: fatty_acid

Prediction, score:

fatty_acid: 31.7
NH2: 12.7
shikimic_acid: 0.0
Acetyl-CoA: 0.0
AHBA: 0.0

ctg1_897

Search NORINE for peptide: strict or relaxed

AMP-binding (522..918): cys

NRPSPredictor2: cys

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic
Large clusters prediction:: cys
Small clusters prediction:: cys
Single AA prediction:: cys

Stachelhaus prediction details:

Stachelhaus sequence:: DLYNLSLIWK
Nearest Stachelhaus code:: cys
Stachelhaus code match:: 100% (strong)

NC_014833.1 - Region 2 - cyclic-lactone-autoinducer

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Location: 1,754,537 - 1,775,363 nt. (total: 20,827 nt) Show pHMM detection rules used

cyclic-lactone-autoinducer: (TIGR04223 or AgrB)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

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Gene details

Select a gene to view the details available for it

MIBiG comparison

KnownClusterBlast

Pfam domains

TIGRFAM domains

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000323.1	0.09	NRP	cichofactin A, cichofactin B	Pseudomonas cichorii
BGC0000463.1	0.09	NRP	xantholysin A, xantholysin B, xantholysin C	Pseudomonas putida
BGC0000435.1	0.09	NRP	syringafactin	Pseudomonas syringae pv. tomato str. DC3000
BGC0000398.1	0.08	NRP	orfamide B	Pseudomonas sp. CMR12a
BGC0001838.1	0.08	NRP	WLIP	Pseudomonas putida
BGC0001842.1	0.08	NRP	gacamide A	Pseudomonas fluorescens Pf0-1
BGC0000399.1	0.07	NRP	orfamide A, orfamide C	Pseudomonas protegens Pf-5
BGC0000425.1	0.07	NRP	sessilin A	Pseudomonas sp. CMR12a
BGC0001980.1	0.07	NRP	lokisin	Pseudomonas sp.
BGC0001509.1	0.07	NRP	anikasin	Pseudomonas fluorescens

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000323.1	0.34	NRP	cichofactin A, cichofactin B	Pseudomonas cichorii
BGC0000463.1	0.34	NRP	xantholysin A, xantholysin B, xantholysin C	Pseudomonas putida
BGC0000435.1	0.34	NRP	syringafactin	Pseudomonas syringae pv. tomato str. DC3000
BGC0000398.1	0.32	NRP	orfamide B	Pseudomonas sp. CMR12a
BGC0001838.1	0.32	NRP	WLIP	Pseudomonas putida
BGC0001842.1	0.30	NRP	gacamide A	Pseudomonas fluorescens Pf0-1
BGC0000399.1	0.29	NRP	orfamide A, orfamide C	Pseudomonas protegens Pf-5
BGC0000425.1	0.28	NRP	sessilin A	Pseudomonas sp. CMR12a
BGC0001980.1	0.28	NRP	lokisin	Pseudomonas sp.
BGC0001509.1	0.28	NRP	anikasin	Pseudomonas fluorescens

Similar known gene clusters

No matches found.

Detailed Pfam domain annotation

Selected features only

Expand to show all names

Detailed TIGRFAM domain annotation

Selected features only

Expand to show all names

NC_014833.1 - Region 3 - RRE-containing

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Location: 1,972,671 - 1,992,738 nt. (total: 20,068 nt) Show pHMM detection rules used

RRE-containing: minimum(1, [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE, Cytolysin_C_RRE, Goadsporin_CD_RRE, Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE, Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE, Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE, Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE, Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE, Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE, Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE, Thiaglutamate_B_RRE, Thiaglutamate_G_RRE, Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE, Thurincin_rSAM_RRE, Trifolitoxin_RRE])

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

MIBiG comparison

KnownClusterBlast

Pfam domains

TIGRFAM domains

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001914.1	0.17	Other	benzastatin J, 7-hydroxyl benzastatin B, 7-hydroxyl O-demethylbenzastatin A, JBIR-67, 7-hydroxyl benzastatin F, 7-hydroxyl O-demethylbenzastatin D, O-demethylvirantmycin, 7-hydroxyl benzastatin D, virantmycin, benzastatin K, methylbenzastatin K	Streptomyces sp. RI18
BGC0001529.1	0.17	Alkaloid	bezastatin derivates	Streptomyces sp. RI18
BGC0000551.1	0.16	RiPP	SapB	Streptomyces coelicolor A3(2)
BGC0000554.1	0.16	RiPP	SRO15-3108	Streptomyces filamentosus NRRL 15998
BGC0001550.1	0.16	RiPP	citrulassin D	Streptomyces katrae
BGC0001549.1	0.16	RiPP	citrulassin B	Streptomyces aurantiacus JA 4570
BGC0000501.1	0.16	RiPP	catenulipeptin	Catenulispora acidiphila DSM 44928
BGC0000802.1	0.16	Saccharide	succinoglycan	Sinorhizobium meliloti
BGC0001552.1	0.16	RiPP	citrulassin F	Streptomyces avermitilis MA-4680 = NBRC 14893
BGC0000504.1	0.16	RiPP	cytolysin ClyLl, cytolysin ClyLs	Plasmid pAD1

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001914.1	0.48	Other	benzastatin J, 7-hydroxyl benzastatin B, 7-hydroxyl O-demethylbenzastatin A, JBIR-67, 7-hydroxyl benzastatin F, 7-hydroxyl O-demethylbenzastatin D, O-demethylvirantmycin, 7-hydroxyl benzastatin D, virantmycin, benzastatin K, methylbenzastatin K	Streptomyces sp. RI18
BGC0001529.1	0.48	Alkaloid	bezastatin derivates	Streptomyces sp. RI18
BGC0000551.1	0.47	RiPP	SapB	Streptomyces coelicolor A3(2)
BGC0000554.1	0.47	RiPP	SRO15-3108	Streptomyces filamentosus NRRL 15998
BGC0001550.1	0.47	RiPP	citrulassin D	Streptomyces katrae
BGC0001549.1	0.46	RiPP	citrulassin B	Streptomyces aurantiacus JA 4570
BGC0000501.1	0.46	RiPP	catenulipeptin	Catenulispora acidiphila DSM 44928
BGC0000802.1	0.46	Saccharide	succinoglycan	Sinorhizobium meliloti
BGC0001552.1	0.46	RiPP	citrulassin F	Streptomyces avermitilis MA-4680 = NBRC 14893
BGC0000504.1	0.46	RiPP	cytolysin ClyLl, cytolysin ClyLs	Plasmid pAD1

Similar known gene clusters

No matches found.

Detailed Pfam domain annotation

Selected features only

Expand to show all names

Detailed TIGRFAM domain annotation

Selected features only

Expand to show all names

NC_014833.1 - Region 4 - ranthipeptide

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Location: 2,251,605 - 2,273,261 nt. (total: 21,657 nt) Show pHMM detection rules used

ranthipeptide: (TIGR03973 or SCIFF or (cds(PF04055 and (TIGR04085 or SPASM)) and minimum(1, [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE, Cytolysin_C_RRE, Goadsporin_CD_RRE, Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE, Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE, Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE, Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE, Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE, Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE, Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE, Thiaglutamate_B_RRE, Thiaglutamate_G_RRE, Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE, Thurincin_rSAM_RRE, Trifolitoxin_RRE]) and not (TIGR01716 or subtilosin or TIGR02111 or TIGR03966 or TIGR04103 or YcaO or TIGR03882)))

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

MIBiG comparison

KnownClusterBlast

Pfam domains

TIGRFAM domains

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001909.1	0.16	Polyketide	strobilurin	Strobilurus tenacellus
BGC0000761.1	0.16	Saccharide	exopolysaccharide	Methylobacillus sp. 12S
BGC0001591.1	0.07	Other	fatty acid enol ester	uncultured bacterium CSLC2
BGC0001688.1	0.07	Other	N-tetradecanoyl tyrosine	uncultured bacterium CSLC2
BGC0001940.1	0.06	Polyketide	pyxidicycline A, pyxidicycline B	Pyxidicoccus fallax
BGC0001281.1	0.04	Polyketide	ustilagic acid	Ustilago maydis 521
BGC0000026.1	0.04	Saccharide	avilamycin A, avilamycin C	Streptomyces viridochromogenes Tue57

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001909.1	0.47	Polyketide	strobilurin	Strobilurus tenacellus
BGC0000761.1	0.46	Saccharide	exopolysaccharide	Methylobacillus sp. 12S
BGC0001591.1	0.27	Other	fatty acid enol ester	uncultured bacterium CSLC2
BGC0001688.1	0.27	Other	N-tetradecanoyl tyrosine	uncultured bacterium CSLC2
BGC0001940.1	0.26	Polyketide	pyxidicycline A, pyxidicycline B	Pyxidicoccus fallax
BGC0001281.1	0.19	Polyketide	ustilagic acid	Ustilago maydis 521
BGC0000026.1	0.17	Saccharide	avilamycin A, avilamycin C	Streptomyces viridochromogenes Tue57

Similar known gene clusters

No matches found.

Detailed Pfam domain annotation

Selected features only

Expand to show all names

Detailed TIGRFAM domain annotation

Selected features only

Expand to show all names