LOCUS       c00035_NZ_FYAX..       10837 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  NZ_FYAX01000014.1 Cupriavidus metallidurans isolate NDB4MOL1, whole
            genome shotgun sequence.
ACCESSION   NZ_FYAX01000014
VERSION     NZ_FYAX01000014
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 6.1.1
            Run date     :: 2024-03-14 14:40:38
            Original ID  :: NZ_FYAX01000014.1
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 135651
            Orig. end    :: 146488
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..10837
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[140651:141488](+)"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193)"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      5001..5837
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193)"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
     cand_cluster    1..10837
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193)"
                     /kind="single"
                     /product="RiPP-like"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..10837
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="RiPP-like"
                     /region_number="1"
                     /rules="(strepbact or Antimicrobial14 or Bacteriocin_IId or
                     BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or
                     Lactococcin or Antimicrobial17 or Lactococcin_972 or
                     Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or
                     TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or
                     TIGR03975 or DUF692 or TIGR01193)"
                     /tool="antismash"
     CDS             complement(3136..3777)
                     /locus_tag="ctg35_124"
                     /transl_table=11
                     /translation="MKTDDLISLLATGIRPVDPHIMRRAFVRALCAGAAGALLLLTMTY
                     GVRPDIRVMLVTPIFWLKVAFPLSLAIGAFVVLKRLVVPGAQVGTRWAVPGVPVLAVWI
                     GALAVLANVPATERLSLMLGMTWRTCPFNIVFLSLPLCVAVVWAVRQMAPTNLRAAGAL
                     AGLLAGSVATIVYCLHCPEMEVPFWAIWYLAGMLIPAALGWLLGPRLLRW"
     PFAM_domain     complement(3139..3750)
                     /aSDomain="NrsF"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF06532.13"
                     /description="Negative regulator of sigma F"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg35_124_0001"
                     /evalue="1.20E-73"
                     /label="ctg35_124"
                     /locus_tag="ctg35_124"
                     /protein_end="213"
                     /protein_start="9"
                     /score="247.4"
                     /tool="antismash"
                     /translation="LATGIRPVDPHIMRRAFVRALCAGAAGALLLLTMTYGVRPDIRVM
                     LVTPIFWLKVAFPLSLAIGAFVVLKRLVVPGAQVGTRWAVPGVPVLAVWIGALAVLANV
                     PATERLSLMLGMTWRTCPFNIVFLSLPLCVAVVWAVRQMAPTNLRAAGALAGLLAGSVA
                     TIVYCLHCPEMEVPFWAIWYLAGMLIPAALGWLLGPRLLRW"
     CDS             complement(3774..4358)
                     /gene_functions="regulatory (smcogs) SMCOG1032:RNA
                     polymerase, sigma-24 subunit, ECF subfamily (Score: 114.8;
                     E-value: 5.7e-35)"
                     /gene_kind="regulatory"
                     /locus_tag="ctg35_125"
                     /transl_table=11
                     /translation="MKPAPERAGMEAMDAVEQRLRALLLAGLGGDQAAYHAFLTELTGR
                     LRAFVRRRLYQLQDEVEDIVQETLLAVHNARHTYRADEPLTAWVYAIARYKLLDFLRSR
                     SRHGETESLDDVADILCHSDDAPAHDARLDLSGLLEQLPDKQRLPILHVKLEGLSVAET
                     ARLTGLSESAVKVGIHRGLKALAAKARLFTS"
     aSDomain        complement(3801..4259)
                     /aSDomain="TIGR02937"
                     /aSTool="tigrfam"
                     /description="sigma70-ECF: RNA polymerase sigma factor,
                     sigma-70 family"
                     /detection="hmmscan"
                     /domain_id="TIGRFam_ctg35_125_0001"
                     /evalue="1.90E-20"
                     /identifier="TIGR02937"
                     /label="ctg35_125"
                     /locus_tag="ctg35_125"
                     /protein_end="186"
                     /protein_start="33"
                     /score="71.1"
                     /tool="antismash"
                     /translation="AYHAFLTELTGRLRAFVRRRLYQLQDEVEDIVQETLLAVHNARHT
                     YRADEPLTAWVYAIARYKLLDFLRSRSRHGETESLDDVADILCHSDDAPAHDARLDLSG
                     LLEQLPDKQRLPILHVKLEGLSVAETARLTGLSESAVKVGIHRGLKALA"
     PFAM_domain     complement(3804..3956)
                     /aSDomain="Sigma70_r4_2"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF08281.14"
                     /description="Sigma-70, region 4"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg35_125_0003"
                     /evalue="1.50E-13"
                     /label="ctg35_125"
                     /locus_tag="ctg35_125"
                     /protein_end="185"
                     /protein_start="134"
                     /score="50.3"
                     /tool="antismash"
                     /translation="LSGLLEQLPDKQRLPILHVKLEGLSVAETARLTGLSESAVKVGIH
                     RGLKAL"
     PFAM_domain     complement(4041..4229)
                     /aSDomain="Sigma70_r2"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF04542.16"
                     /description="Sigma-70 region 2"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg35_125_0002"
                     /evalue="1.90E-12"
                     /label="ctg35_125"
                     /locus_tag="ctg35_125"
                     /protein_end="106"
                     /protein_start="43"
                     /score="46.9"
                     /tool="antismash"
                     /translation="GRLRAFVRRRLYQLQDEVEDIVQETLLAVHNARHTYRADEPLTAW
                     VYAIARYKLLDFLRSRSR"
     CDS             4685..4969
                     /locus_tag="ctg35_126"
                     /transl_table=11
                     /translation="MNTIKLAAAVTLAALTSGVALAQNSTMQQSKDKPAMEKCYGVAMA
                     GQNDCKAGAGTTCAGTQKTDYERDHFKSVPVGTCATIKTPHGMGTLKPM"
     PFAM_domain     4790..4945
                     /aSDomain="DUF2282"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF10048.11"
                     /description="Predicted integral membrane protein
                     (DUF2282)"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg35_126_0004"
                     /evalue="7.10E-24"
                     /label="ctg35_126"
                     /locus_tag="ctg35_126"
                     /protein_end="87"
                     /protein_start="35"
                     /score="83.7"
                     /tool="antismash"
                     /translation="MEKCYGVAMAGQNDCKAGAGTTCAGTQKTDYERDHFKSVPVGTCA
                     TIKTPHG"
     CDS             5001..5837
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: DUF692"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg35_127"
                     /sec_met_domain="DUF692 (E-value: 2.6e-101, bitscore:
                     331.4, seeds: 7, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTATPRAGLGLKPQHFEQALQCAEPGLWFEVHPENYLMAGGPRLA
                     WLTAIRERHPVALHGVSLSLAGDAPPDEAHLDRLHALLRRIEPVLVSEHLAWSTLDGRY
                     VPDLLPVARTTARLAQVAANISRVQDRLGCAIALENPSHYLRMDEHDWSETDFLAELVR
                     RTGCGLLLDINNVYVSARNMGYDAWDYLTRVPAEAVREIHLAGHSFDDEFGASLLIDSH
                     DAPVAEAVWSLYRRFVARVGERPTLIERDDNIPEFADLLDERNHAQSILDAEVATS"
     PFAM_domain     5019..5813
                     /aSDomain="DUF692"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF05114.15"
                     /description="Protein of unknown function (DUF692)"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg35_127_0005"
                     /evalue="1.60E-100"
                     /label="ctg35_127"
                     /locus_tag="ctg35_127"
                     /protein_end="271"
                     /protein_start="6"
                     /score="335.8"
                     /tool="antismash"
                     /translation="AGLGLKPQHFEQALQCAEPGLWFEVHPENYLMAGGPRLAWLTAIR
                     ERHPVALHGVSLSLAGDAPPDEAHLDRLHALLRRIEPVLVSEHLAWSTLDGRYVPDLLP
                     VARTTARLAQVAANISRVQDRLGCAIALENPSHYLRMDEHDWSETDFLAELVRRTGCGL
                     LLDINNVYVSARNMGYDAWDYLTRVPAEAVREIHLAGHSFDDEFGASLLIDSHDAPVAE
                     AVWSLYRRFVARVGERPTLIERDDNIPEFADLLDERNHAQSIL"
     CDS             5834..6595
                     /locus_tag="ctg35_128"
                     /transl_table=11
                     /translation="MNANGHRFQDDFLRAILAPPGIAPPWTPITPLTQQPGFKVYRNTV
                     LKGCVDALAANFPTVLRLVGEDWFRAAALIHVCAEPPRSVCLIEYGQEFADFLSGFEPA
                     AALPYLPDVARLDRLWTESHLAADDEALDAAALATLNGGELLGAALRPCASVRWRWFET
                     PAFTIWRANREQRDLEGELDWIGEGALLTRPEGAVVWQHATQGMCAFLDACAAGASLQI
                     ACQSATIAEPGIDIARLLATLLGTRVFADIH"
     PFAM_domain     5855..6127
                     /aSDomain="DUF2063"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF09836.11"
                     /description="Putative DNA-binding domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg35_128_0006"
                     /evalue="2.00E-21"
                     /label="ctg35_128"
                     /locus_tag="ctg35_128"
                     /protein_end="98"
                     /protein_start="7"
                     /score="76.1"
                     /tool="antismash"
                     /translation="FQDDFLRAILAPPGIAPPWTPITPLTQQPGFKVYRNTVLKGCVDA
                     LAANFPTVLRLVGEDWFRAAALIHVCAEPPRSVCLIEYGQEFADFL"
     CDS             6621..7091
                     /locus_tag="ctg35_129"
                     /transl_table=11
                     /translation="MSNVSHTDSPVRADTTLWSNLTTRASRLISDSFLALLARLAIASV
                     FFLSGRTKVTGLLTIKDSTYSLFEQEYNLPLIPPELAAHLAAYAEHLFPVLLVLGLFTR
                     FSAFALLGMTLVIEIFVYPDAWPTHLTWAALQLFLIGRGAGAFSLDRRFGIK"
     PFAM_domain     6723..6986
                     /aSDomain="DoxX"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF07681.14"
                     /description="DoxX"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg35_129_0007"
                     /evalue="2.20E-20"
                     /label="ctg35_129"
                     /locus_tag="ctg35_129"
                     /protein_end="122"
                     /protein_start="34"
                     /score="73.1"
                     /tool="antismash"
                     /translation="ALLARLAIASVFFLSGRTKVTGLLTIKDSTYSLFEQEYNLPLIPP
                     ELAAHLAAYAEHLFPVLLVLGLFTRFSAFALLGMTLVIEIFVY"
     PFAM_domain     7476..8789
                     /aSDomain="SCFA_trans"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF02667.16"
                     /description="Short chain fatty acid transporter"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg35_130_0008"
                     /evalue="1.10E-125"
                     /label="ctg35_130"
                     /locus_tag="ctg35_130"
                     /protein_end="438"
                     /protein_start="0"
                     /score="420.2"
                     /tool="antismash"
                     /translation="LSKVAGFFTELMRRYLPDPFVFAIGLTLLTMVMAMLVEGQAAQAV
                     ITNWGKGFWNLLSFTTQMAVILAMGYVLATAPLVDRFLNAIVARVQTPRGAIIVATLVG
                     GIGSYLNWGFGLVIGGIIARKLALKVKGVHYPLIIASAYSGFTMYGLGLSASIPVLIST
                     PGHPMEKLMGVIGLKETIFSTPMLLTSLAVIVTLPLLNAMLHPRDAKEVVEIREENTAE
                     DHAAGHGHSMGIENTLATRMNNSRLLSLIIGLCGLAYAGLHFSQGGSLDLNLINFLILF
                     IGVLLLGTPANYVAKLNEGIKTISGIILQYPFYAGIMAVMAGSGLVDSISRVFVDIATP
                     QTLPFWGLVSSFVINFFAPSGGGHWVIQGPFMIDAAKAINSSVAQTSMSVMLGNAWNDL
                     VQPFWILPALALSKLKLKDVMGYTVIMMFWVGAIYIVAM"
     CDS             7476..8813
                     /locus_tag="ctg35_130"
                     /transl_table=11
                     /translation="LSKVAGFFTELMRRYLPDPFVFAIGLTLLTMVMAMLVEGQAAQAV
                     ITNWGKGFWNLLSFTTQMAVILAMGYVLATAPLVDRFLNAIVARVQTPRGAIIVATLVG
                     GIGSYLNWGFGLVIGGIIARKLALKVKGVHYPLIIASAYSGFTMYGLGLSASIPVLIST
                     PGHPMEKLMGVIGLKETIFSTPMLLTSLAVIVTLPLLNAMLHPRDAKEVVEIREENTAE
                     DHAAGHGHSMGIENTLATRMNNSRLLSLIIGLCGLAYAGLHFSQGGSLDLNLINFLILF
                     IGVLLLGTPANYVAKLNEGIKTISGIILQYPFYAGIMAVMAGSGLVDSISRVFVDIATP
                     QTLPFWGLVSSFVINFFAPSGGGHWVIQGPFMIDAAKAINSSVAQTSMSVMLGNAWNDL
                     VQPFWILPALALSKLKLKDVMGYTVIMMFWVGAIYIVAMLAWGAQI"
     PFAM_domain     8836..9099
                     /aSDomain="YCII"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF03795.16"
                     /description="YCII-related domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg35_131_0009"
                     /evalue="7.90E-19"
                     /label="ctg35_131"
                     /locus_tag="ctg35_131"
                     /protein_end="88"
                     /protein_start="0"
                     /score="68.0"
                     /tool="antismash"
                     /translation="MPYLIETFDKPEHQHVRQANRPAHLEFLAENSKLLLACGAKLNDD
                     GSDGGGGIYIVDVDTREAARALIEADPFFTAGLFADIRIVRWR"
     CDS             8836..9132
                     /locus_tag="ctg35_131"
                     /transl_table=11
                     /translation="MPYLIETFDKPEHQHVRQANRPAHLEFLAENSKLLLACGAKLNDD
                     GSDGGGGIYIVDVDTREAARALIEADPFFTAGLFADIRIVRWRKAYLDGVCHL"
     CDS             9155..10213
                     /locus_tag="ctg35_132"
                     /transl_table=11
                     /translation="MKRWKQRPEGANWGDFGDDDQLGRLNLITADRVRAAAREIRSGKT
                     FCLSLPLDLPGGNVLNPRRHPPVLRPTFRDDVAYVNFPLAKVDPNALDVLSDDQVLLSM
                     QYSTQWDSLAHVGALFDADGDGVAERVYYNGFRPNTDIVGPVDYAEGDDFSAHPCGHDH
                     SHADALGIETFAAHGIQARGVLVDLAAHYGRECRTVGYDDLMRVIEADGIVVEPGDILV
                     LRTGFAEMVMEMAGQPDAEVLHHSCCALDGRDERLLQWITDSGIAAIAADNYAVERYPA
                     RPAPEGAGPVPMLPLHHHCLFKLGLPLGELWYLRDLAAWLRAEGRHHFFLSAPPLRLPG
                     AMGSPVTPVATV"
     PFAM_domain     9419..9985
                     /aSDomain="Cyclase"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF04199.15"
                     /description="Putative cyclase"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg35_132_0010"
                     /evalue="1.40E-12"
                     /label="ctg35_132"
                     /locus_tag="ctg35_132"
                     /protein_end="277"
                     /protein_start="88"
                     /score="48.2"
                     /tool="antismash"
                     /translation="PNALDVLSDDQVLLSMQYSTQWDSLAHVGALFDADGDGVAERVYY
                     NGFRPNTDIVGPVDYAEGDDFSAHPCGHDHSHADALGIETFAAHGIQARGVLVDLAAHY
                     GRECRTVGYDDLMRVIEADGIVVEPGDILVLRTGFAEMVMEMAGQPDAEVLHHSCCALD
                     GRDERLLQWITDSGIAAIAADNYAVE"
     PFAM_domain     10242..10508
                     /aSDomain="MIase"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF02426.18"
                     /description="Muconolactone delta-isomerase"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg35_133_0011"
                     /evalue="1.20E-39"
                     /label="ctg35_133"
                     /locus_tag="ctg35_133"
                     /protein_end="89"
                     /protein_start="0"
                     /score="134.4"
                     /tool="antismash"
                     /translation="MLFMVEMTVRIPQSLDPEVADAIKAKEKAYSQQLQRDGKWRHLWR
                     VAGLYANVSIFDVKDADELHTLLTGLPLYPYMEMKVTALAQHGS"
     CDS             10242..10526
                     /locus_tag="ctg35_133"
                     /transl_table=11
                     /translation="MLFMVEMTVRIPQSLDPEVADAIKAKEKAYSQQLQRDGKWRHLWR
                     VAGLYANVSIFDVKDADELHTLLTGLPLYPYMEMKVTALAQHGSAIAQN"
     aSDomain        10245..10514
                     /aSDomain="TIGR03221"
                     /aSTool="tigrfam"
                     /description="muco_delta: muconolactone delta-isomerase"
                     /detection="hmmscan"
                     /domain_id="TIGRFam_ctg35_133_0002"
                     /evalue="1.10E-44"
                     /identifier="TIGR03221"
                     /label="ctg35_133"
                     /locus_tag="ctg35_133"
                     /protein_end="91"
                     /protein_start="1"
                     /score="148.4"
                     /tool="antismash"
                     /translation="LFMVEMTVRIPQSLDPEVADAIKAKEKAYSQQLQRDGKWRHLWRV
                     AGLYANVSIFDVKDADELHTLLTGLPLYPYMEMKVTALAQHGSAI"
ORIGIN
        1 gcgcgttctg cacggccttg aggtgggcaa aaagcgcatc cgaatcgctc aggagggcct
       61 ggaacgcctt cgagtcgccg aggatcgcat cgagcgcggc gaacagcgcc ttgccttcgg
      121 ccaccagcgc ggccaccgtg ccgaggtcgc cagcaagcgc cgaggcgacg ttggcggcct
      181 gaaccagcga ctgacgcagg ccagagggta gcgagacacc agcgaccgtc gcacccgcgg
      241 tggcgcgcaa ttgatccgag gcgctctgca cagccgtgat cgccgtggcg agattgggca
      301 gagcaggcgc tgcgtcgatc gacgtgttga ccagtggcgc gatagcgttg ctgagcgcgg
      361 tcagcgcggc ttgcagggcg tccagtcgcg cctgcgcatc ggcaacgagc cccggtgcgt
      421 aggtggcggc ctgctgtttc aggtctgcca ccgtcgagcc gatggcgctc accccgcccg
      481 tggcggcgct gccggtctgc ccggccagcc caggcaaggc ggcataaagc tgcgccagac
      541 cgttcaggaa tagttcggcc tggctgccgc actccgagac gaagcgcggc acctgctcgg
      601 gcgtgtccac caacgacgtc actgtctcga tgaccgcgcc aagtggaatg catccgaaca
      661 gcaacggaag gttgggcagc ccggcgctgg ggaaggcatc cgagccggtc atgcttccgc
      721 ccacgaaatc ggccacagtg ccggtgaccg gccccgtcag gcgagacacc gcgctcggat
      781 tgaggttcgg ctggacgaag ccgccggcgc gatccccctg tgcggagaaa tcgagccggg
      841 ccttgttctt cggatcgttt ggcacgatgt tgacgaacac ctgccccttg ttatccgcgc
      901 cgaactcgct ggtcaggtag gtgttgttcc attccaccac gttggcgtcg ccgctgcccg
      961 taagctgcgc caatgcagga atgcgcaccg tggcccgaac caccttcgga tagaaggcag
     1021 gacgctgctg ggtctggccg tacgccttca gcgttggatt gccggtgcca gcttccgcgc
     1081 cgaagcgtag ctcgcgcacc tccagcatcg tgtcaccggg ctgggcgctg cgtgccagcg
     1141 tcatcgattg cggcgccatc gtcgcgccac gtcccgtgcc ggggacctcg ccaggtggca
     1201 gcccttgatc ccaaagcgtc tgcgccttgg cgaacgtgtc gttcgcagtg ctcgggtcca
     1261 tggcgatgga ttcatacatg aacaccatcg gcaggtcgaa gcggatagcg cgcccgtcga
     1321 gatccgtgcc ttcgcagcgg aatggaaacg gcacgccgcc gaccaggggc cagatcgggg
     1381 ccgtcgtcgg cgtcaccggg ctcaggtccg gcgtcaccag gctcaggatg cgcacgctgg
     1441 tcaggggcat ctgcagatgc agttgcgtgc gaccatcggt atcgctgcgc agatcggtct
     1501 ccgtgaagga ccgctcgcgt tcgcgcacga tgatgaacgt gcgcttgcgc agcaccgccg
     1561 cattgccggg cacgccgcca tgctggaatt ttcgctcggt gacttcgacc agcaccgccc
     1621 ggtgcccgaa gggccataga aacccacgct tgaccgtgcg cacgtagtgg tcacgcccca
     1681 tgctgccgcg atgggtccag gcgacgagat cgatcgactg ggggccgtcc catatgccac
     1741 gcacgttgat ccacgcgccc agcgcggaga gcatcaactg atcggcagga atcgcggcgg
     1801 gggtgtagcc cgagcgcgag aagttggacg acagatggac aatgctgtag cggtccatgt
     1861 cgttgagtgc tgccttgaac ggcatgtccg cgggattggg cagttccccg acggcggccg
     1921 gaaacttggc ctgcatcggc ttcgacgtcc cttcacccgc cagcgcccag accgcgcgca
     1981 cgatgcggtt ggggtcgggg tgcgggggca cgatggtgcc ctgatcggtg ggtgccgcga
     2041 gctgggtgtg ccatagctcc gtatgtccgt ccggcgtggt gactggcgcc accgcgtgat
     2101 gccagcgctc atcggcatcg gggctcagga tcaggcgcca gggtacctcc agcgcggtct
     2161 gctgggcagt aggctcggcg ggacggggtt tcaggcccga caggatcgga cccagcccga
     2221 cgtccgtggt aacgccccgg cgaacgtcga tggccggcag ggccgcacgg cgccgtgccg
     2281 tagccggggc cacctgccgc cgctcaagcg tcgacgtatc gcgctggacc gacgcgagct
     2341 tcaggttgcg tagcgtgacg ctcggcaggg cggcgcgctg ggccagcgtc aggctgccgg
     2401 ttgcctgcgc gatcagcccg ccgagccatt cgggaaaaga caggggcggt tgcgcggccg
     2461 tgggcggcag ggcgttggcg cccacggcca gcggcagatc gcgcacggcc gtgagcacgc
     2521 cttcgagcgt gtaagggata tcgaagccat caggcacggc aaacgcgatc cgcgattcgc
     2581 ccgcgatacg ggcgcgcgcc ggcagcgtga cggggggatc aacggctggt ggggaggatt
     2641 cggcgaacgc ctgctcgaag atcgattgag gcggaaaatg caggaccagc gtggccacgc
     2701 cgctgccggt cttgcgcagc cgtggcgggc tgcctcgctg cacggtcaga ttgttcagtt
     2761 ccacccgcag cacgagcagg tcgtcctgcc ggaccaccgg ctgaccgggg cggcccgcgt
     2821 cgaagaaatt ctgattggga tcgggcgcga cagggagcgg gatcgggatc ggaatcggcc
     2881 ggattaccac ggggccatcg acacgcgttt tgactgaagc tgtcttgccg gcggccggcg
     2941 tcggcctgcg cgggactctg ctgaccatcg cagccccctt tcagagaatg ttctgattgt
     3001 ttgcaagaaa cggggtcacg ggcagcgtcc cgggacacag ccaatatatt cagtccgcgc
     3061 gtttgcggaa ttcgatatct tgcagatcag atctgagacg ggccacgcgc gggggcaggg
     3121 tgtggccgcg gggtctcacc agcgaagcag gcgtggaccg agcagccagc ccagcgccgc
     3181 cggaatcagc atcccggcca gataccagat tgcccagaac gggacctcca tttccgggca
     3241 atgcaggcaa tagacgatag ttgccaccga accggcgagc agccccgcca gggcgccggc
     3301 ggcgcggagg ttcgttgggg ccatctgccg aaccgcccag accaccgcga cgcacagcgg
     3361 caaggacagg aacacgatat tgaacgggca ggtcctccac gtcatgccga gcatcagtga
     3421 cagccgctcg gttgccggca cattggccag taccgccagg gcgccgatcc acaccgccag
     3481 caccggcacg cccggcaccg cccaacgggt acccacctgc gcgccgggca ccaccagccg
     3541 tttcagcaca acgaatgcgc cgattgccag cgacagcgga aacgccacct tgagccagaa
     3601 gatcggcgtg accagcatca cgcggatgtc tgggcgcacc ccatacgtca tggtcagcag
     3661 caggagcgcg ccggcggcac cggcgcagag cgcccggacg aacgcccggc gcatgatgtg
     3721 cgggtccacc gggcggatgc cggtggccag cagggagatg agatcgtctg tcttcatgat
     3781 gtgaacaggc gcgctttggc ggccaatgcc ttaagcccgc gatgaatacc taccttgacc
     3841 gccgattcgg acagccccgt cagccgtgcg gtctccgcca ccgacaggcc ctcaagcttc
     3901 acatgcagga tgggtaaccg ctgtttgtcc ggcagttgct cgagcaggcc gctcagatcg
     3961 agtcgtgcat cgtgcgccgg cgcatcgtcg ctatggcaga ggatgtccgc gacatcgtcc
     4021 agcgactccg tctccccgtg acgggaacgg ctacgcagga agtccagcag cttgtagcgg
     4081 gcaatcgcgt aaacccacgc cgtcagcggt tcatcggcgc ggtaggtgtg ccgggcgttg
     4141 tgcaccgcca gaagcgtttc ctggacgatg tcctcgactt catcctgcaa ctgataaagc
     4201 cgccgccgga caaaggcgcg cagccggccg gtcagttcgg tcaggaatgc atgataggcg
     4261 gcctgatcgc cacccaggcc ggccaggagc agcgcgcgca ggcgctgctc caccgcatcc
     4321 atggcctcca tgccggcgcg ctcgggagcg ggcttcatgc aagcgacgac tgcgcggaga
     4381 tttgatcgat caacatcgtc acgaggttca ggggtgatcg cttcgaaatg atatgtgagt
     4441 gcacccatgg cgacaatccg cgtgcatgtg cttctccgtt attcgtcggc aggcgccatc
     4501 cggttacagc ggaccacaaa aaaatattct cccgggcggc tgtaaccggt ggcggatccc
     4561 ccgcgaattg acagtcagat catccgacca ccgggcccag caacccagcg ccgcgaggcc
     4621 ggccagacgg gaccacggat atctgacttc ctttcacatt gattcgctct caaggagtat
     4681 cgccatgaac accatcaagc tcgccgccgc cgtgaccctg gccgccctga cttcgggcgt
     4741 cgccctggcg cagaacagca ccatgcagca gtccaaggac aagcccgcca tggagaagtg
     4801 ctacggcgtg gccatggccg gccagaacga ttgcaaggcg ggggcgggca cgacgtgcgc
     4861 cggcacccag aagaccgatt acgagcgcga ccacttcaag tccgtgcccg ttggtacctg
     4921 cgcgacgatc aagacgccgc acggcatggg cacgctgaag ccgatgtaag ccggatagca
     4981 gcccgttgga gacgtcaatc atgacagcga caccacgcgc ggggcttgga ctcaagccgc
     5041 aacacttcga gcaggcgctg caatgcgccg agccgggcct gtggttcgag gtccacccgg
     5101 agaactacct gatggccggc ggtccgcgcc tggcgtggct gacggctatc agggagcgcc
     5161 atccggtggc actgcacggc gtgtcgctgt cattggcggg cgatgccccg ccggacgagg
     5221 cgcatctcga tcggcttcac gcacttttgc ggcggatcga gccggtgctg gtttccgagc
     5281 atctggcgtg gtcgacgctg gacgggcgct acgtgcccga tctgctgccg gtggcgcgga
     5341 ccacggcccg actggcgcag gtggcggcca atatctcccg ggttcaggac cgccttggat
     5401 gtgccatcgc gctggagaac ccgtcgcact acctgcgcat ggacgagcac gactggagcg
     5461 agaccgattt tctggccgaa ctggtgcggc gcaccggctg cgggttgctg ctcgacatca
     5521 acaatgttta cgtcagcgcc cgaaacatgg gttacgacgc gtgggactac ctgacacgcg
     5581 tgccggccga agccgtgcgg gagattcatc tggccggaca cagcttcgac gacgagttcg
     5641 gcgcgtcact gctgatcgat tcgcacgatg cgccggtggc ggaggccgtc tggtcgctat
     5701 atcgccgctt cgtggcgcgg gtcggtgagc gtccgacgct gatcgaacgg gacgacaaca
     5761 ttcccgaatt cgccgacttg ctcgacgagc gcaatcacgc gcagtccatc ctggacgcgg
     5821 aggtcgccac atcatgaacg ccaacggaca tcgctttcag gacgacttcc tgcgcgccat
     5881 tctggcgccg ccgggcatcg cgccgccgtg gaccccaatc acgccgctga cgcagcagcc
     5941 tggcttcaag gtctatcgca acaccgtgct caagggctgt gtggatgcgc tggccgcgaa
     6001 tttcccgacg gtcctgcggc tggtagggga ggactggttt cgcgcggcgg cactgatcca
     6061 cgtctgcgcg gagcccccgc gcagcgtctg cctgatcgag tatgggcagg aattcgcgga
     6121 cttcctgtcg ggattcgagc ctgccgcggc actgccatac ctgccagacg tggcacgtct
     6181 ggatcgcctc tggaccgagt cccacctggc cgccgatgat gaggcgctgg acgcggcggc
     6241 actggccacg ctgaacgggg gtgagctcct tggcgcggcg ctacggccat gcgccagcgt
     6301 gcgttggcgc tggttcgaaa cgcctgcgtt cacgatctgg cgggcaaatc gggagcagcg
     6361 tgacctcgaa ggcgaactgg attggatcgg ggagggcgcc ttgctgacgc ggccagaagg
     6421 tgccgtggtc tggcaacacg ccacgcaggg catgtgcgcc tttctggatg cctgcgctgc
     6481 cggcgccagc cttcagatcg cctgccagtc cgccacgatt gccgagcccg gcatcgacat
     6541 cgcccgcctg ctggccacgc tgcttggcac gcgggttttc gcagacattc actgagccta
     6601 tccagcttgc cgaggtagcc atgtcaaacg tatctcatac cgattcccca gtgcgggccg
     6661 ataccacgct ctggtcgaac cttacaacgc gggcctcgcg gctgatcagc gactcgtttc
     6721 tggcattgct ggcacggctg gcgatcgcct cggtgttctt tctgtcgggc cgcaccaagg
     6781 tcaccgggct gctgacgatc aaggacagca cctattcgct gttcgagcag gagtacaacc
     6841 tgccgctgat cccgcccgaa ctcgcggccc atctggccgc gtacgccgag cacctgtttc
     6901 cggtgctgct ggtgctcggc ctgttcacgc gattttcggc attcgcgctg ctggggatga
     6961 cgctggtcat cgaaatcttt gtctatcccg atgcctggcc cacgcacctg acctgggccg
     7021 cgctgcaact cttcctgatt ggccggggtg cgggcgcctt ctcgctcgac cggagattcg
     7081 gcatcaagta gccctcaagt ggacctcaac ctggcccgag aatcctctcg ggtcttttcc
     7141 ttccgccccg gcacgctcgt tggccggggc attccccttt ctgcatagcg gttctgtgcg
     7201 gatatcggcc agatcgaggc cgtctgtccg cacgtcaatg ctgcactgcg caatcgcatt
     7261 cccggcgtat tcacaaggcc gaaagcccca ggcgtggccg accatgtcgc gctgcgatgc
     7321 agcatcggat cattgtgact tccgcactaa ttaagcaatt cattaacttg actttgcgca
     7381 ttcggacttt tacgctcccg atcttcatac aagacgttcg catgtagaac gctagttcga
     7441 tatgcgttca tttcggcttt cgtaggagac agatcttgag taaggtcgcc gggttcttta
     7501 ctgaactgat gcgccggtat ttgccggacc cctttgtatt cgccatcggc ctgacgttgc
     7561 tgacgatggt catggcaatg ctggtagaag gacaggccgc ccaggcggtc atcacgaact
     7621 ggggcaaggg gttctggaac ctgctctcgt tcaccaccca gatggcggtg attctggcga
     7681 tgggctacgt gctggccacc gcgccgctgg tcgaccgctt cctcaacgcc atcgtcgccc
     7741 gcgtgcagac gccgcgcggc gccatcatcg tggccacgct ggtaggcggt atcggcagct
     7801 acctgaactg gggcttcggc ctggtgatcg gcggcatcat cgcccgcaag ctggcactga
     7861 aggtcaaggg tgtgcattac cccctgatca tcgcctcggc ctacagcggc ttcacgatgt
     7921 atggcctggg cctgtccgcc agcatccccg tactgatctc caccccgggt cacccgatgg
     7981 aaaagctgat gggcgtgatc ggtctcaagg agacgatctt ctccacgccg atgctgctga
     8041 cgagccttgc cgtcatcgtc acgctgccgc tgctcaacgc aatgctgcac ccgcgtgatg
     8101 ccaaggaagt ggtggaaatc cgcgaggaga acaccgccga ggaccacgcc gccgggcacg
     8161 gccacagcat gggcatcgag aacacgcttg ccacgcgcat gaacaacagc cgcctgctga
     8221 gcctgatcat cggcctgtgc gggctggcct acgccggtct gcatttctcg cagggcggtt
     8281 cgctggacct gaacctgatc aacttcctga tcctgttcat cggcgtgctg ctgctgggca
     8341 ccccggccaa ctacgtggcc aagctgaacg aaggcatcaa gacgatctcc ggcatcatcc
     8401 tgcagtatcc gttctacgca ggcatcatgg cggtcatggc cggctccggg ctggtggaca
     8461 gcatctcgcg cgtgttcgtc gatatcgcca cgccgcagac gctgccgttc tggggtctgg
     8521 tcagctcgtt cgtgatcaac ttcttcgcgc cgtccggcgg tggccactgg gtgatccagg
     8581 gtccgttcat gatcgacgcg gccaaggcca tcaacagctc ggtggcgcag acgtcgatgt
     8641 cggtcatgct cggcaacgcc tggaatgacc tggtgcagcc gttctggatt ctgccagcgc
     8701 tggcgctgtc gaagctgaag ctcaaggacg tgatgggcta caccgtgatc atgatgttct
     8761 gggtcggcgc gatctacatc gtcgccatgc tggcctgggg cgcgcagatc tgacaaccga
     8821 tacaggagac attcgatgcc gtacctcatt gagaccttcg acaagcccga acaccagcac
     8881 gtacgccagg ccaaccggcc cgcgcacctg gagttcctgg cggagaacag caagctgctg
     8941 ctggcctgcg gggccaagct caatgatgac ggcagcgatg gcggcggtgg catctacatc
     9001 gtcgacgtgg atacacgcga ggccgcgcga gcactgatcg aggccgatcc gttcttcacg
     9061 gccggcctgt tcgccgacat tcggatcgtg cgctggcgca aggcgtatct ggatggcgtc
     9121 tgccatctct gaacgccagt ccggagcgcc agccatgaaa cgatggaagc aacgtcccga
     9181 aggcgccaac tggggcgact tcggcgatga cgaccaactc ggccgcctga acctgattac
     9241 cgcggaccgc gtgcgtgccg ccgcgcgcga aatccgcagc ggcaagacgt tctgcctgtc
     9301 cctgccactc gatctgccgg gcggcaatgt tctcaatcca cgccggcatc cgccggtgct
     9361 gcgacccacg ttccgtgacg acgtggcgta cgtcaacttt ccgctggcca aggtcgaccc
     9421 aaacgcgctt gatgtcctga gcgacgacca ggtactgctg tcgatgcagt actcgacgca
     9481 gtgggattcc ctggcccacg tcggcgcgct gttcgatgcc gacggcgacg gcgtggccga
     9541 gcgggtctac tacaacggct ttcgccccaa taccgacatc gtcgggccgg tcgactacgc
     9601 ggaaggcgac gatttctccg cgcacccgtg cggccatgac cacagccacg ccgacgcgct
     9661 cggcatcgag accttcgccg cgcacggtat ccaggcgcgt ggcgtgctgg tcgatctggc
     9721 cgcgcattac gggcgcgagt gccgcacggt cggatacgac gacctgatgc gcgtgatcga
     9781 ggccgatggc atcgtggtcg aacccggcga catccttgtg ctgcgcaccg ggtttgccga
     9841 gatggtgatg gagatggccg gccaacccga cgccgaggtg ctgcaccaca gttgctgcgc
     9901 gctggacggc cgcgacgaac gcctgctgca atggatcacc gattccggca tcgccgcgat
     9961 cgccgcggac aactacgccg tggaacgcta tccggcacgg cccgcgccgg agggagcagg
    10021 gccggtgccg atgctgccgc tgcatcatca ttgcctgttc aagctcggcc tgccgctggg
    10081 cgagctgtgg tacctgcgcg atctcgccgc atggctgcgt gccgagggtc gccatcactt
    10141 tttcctgtcg gcgccgccgc tgcggctgcc gggtgcgatg gggtcgccgg tgacgcccgt
    10201 cgccaccgtc tgatttcgcc ggattcacaa ggagccccca catgctgttc atggtggaaa
    10261 tgaccgtccg catcccccaa tcgctcgacc cggaagtggc cgacgcaatc aaggccaagg
    10321 aaaaagccta ttcgcagcaa ctgcagcgcg acggcaagtg gcgccatctg tggcgcgtgg
    10381 ctggccttta tgccaacgtc agcatcttcg acgtaaagga tgccgacgaa ctgcacacgc
    10441 tgctgaccgg cctgccgctg tatccgtaca tggaaatgaa ggtcaccgcg ctggcgcagc
    10501 acggctcggc catcgcgcag aactgaacca cgggagccgt catgcctttc gccgacctct
    10561 ccgacgtccg gatccattac cgcctggatg gcgccgagca cctgccagtg ctggtgctct
    10621 ccaactcgct cggcaccacc gccgacatgt ggcagccgca gatcgccgcg ctgtcccaac
    10681 acttccgcgt gctgcgctat gacacgcgcg gccatggcga gtcgggcgtg acgcccggcc
    10741 cgtacagcat cgcgcagctt ggcggcgatg tgatcgggtt gctcgaccat ctgggtctgc
    10801 agcgcgtgca tttctgcggg ttgtcgatgg gcggcat
//
