LOCUS       NZ_HF545616.1          18898 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  NZ_HF545616.1 Ruminococcus bicirculans (ex Wegman et al. 2014)
            strain 80/3 chromosome I, complete sequence.
ACCESSION   NZ_HF545616
VERSION     NZ_HF545616.1
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 6.1.1
            Run date     :: 2024-03-14 13:29:56
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 257367
            Orig. end    :: 276265
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     CDS             complement(1..942)
                     /locus_tag="ctg1_226"
                     /transl_table=11
                     /translation="MPKNRTIPFGYCMKNGEITTEPKEVYAVVAIFDEYLKGRSLSEIA
                     KLMQSEKIRYNAISDKWNKNMVKRIIENERYLGTEKYPQLIAEDIFRQANEKRVKKATT
                     LNLISDDLQEIRNVTYCAECGHKLSRIGGNSKYEHWDCKNHDCYKLEYRITDQMIIGAV
                     LNVINSAIANPSLLESGGEISTYSPTADVIRKQNEINQMTDSPQVDFDRVKSEIFKLAE
                     MKYDCCTYNDSPQKTEEIKALLENHKQLNTLDIGLFKACVSRIWISHFCVIEVELINGI
                     RIKNITERNEKNVHSAECNDNSCESANSGKQG"
     protocluster    1..18898
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[266290:266866](+)"
                     /cutoff="20000"
                     /detection_rule="(TIGR04223 or AgrB)"
                     /neighbourhood="10000"
                     /product="cyclic-lactone-autoinducer"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      8924..9499
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(TIGR04223 or AgrB)"
                     /neighbourhood="10000"
                     /product="cyclic-lactone-autoinducer"
                     /protocluster_number="1"
     cand_cluster    1..18898
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(TIGR04223 or AgrB)"
                     /kind="single"
                     /product="cyclic-lactone-autoinducer"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..18898
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="cyclic-lactone-autoinducer"
                     /region_number="2"
                     /rules="(TIGR04223 or AgrB)"
                     /tool="antismash"
     PFAM_domain     complement(607..879)
                     /aSDomain="Recombinase"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF07508.15"
                     /description="Recombinase"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_226_0021"
                     /evalue="3.90E-12"
                     /label="ctg1_226"
                     /locus_tag="ctg1_226"
                     /protein_end="112"
                     /protein_start="21"
                     /score="46.6"
                     /tool="antismash"
                     /translation="PKEVYAVVAIFDEYLKGRSLSEIAKLMQSEKIRYNAISDKWNKNM
                     VKRIIENERYLGTEKYPQLIAEDIFRQANEKRVKKATTLNLISDDL"
     CDS             complement(1054..1362)
                     /locus_tag="ctg1_227"
                     /transl_table=11
                     /translation="MYTIEYLPIARRDMVDIAKYIGVKLANPDAAERLAEKMVESAEDL
                     ANMPYKCPMYIPVKPLKHEYRKLIVHNYIMFYWIDEDKKLVTIARVVYSGRDYEKLL"
     PFAM_domain     complement(1069..1353)
                     /aSDomain="ParE_toxin"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF05016.17"
                     /description="ParE toxin of type II toxin-antitoxin system,
                     parDE"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_227_0022"
                     /evalue="2.50E-12"
                     /label="ctg1_227"
                     /locus_tag="ctg1_227"
                     /protein_end="98"
                     /protein_start="3"
                     /score="47.4"
                     /tool="antismash"
                     /translation="IEYLPIARRDMVDIAKYIGVKLANPDAAERLAEKMVESAEDLANM
                     PYKCPMYIPVKPLKHEYRKLIVHNYIMFYWIDEDKKLVTIARVVYSGRDY"
     CDS             complement(1362..1637)
                     /locus_tag="ctg1_228"
                     /transl_table=11
                     /translation="MDMNMIRPVSDLRNNFADISKTVHETAQPVFLTKNGYGDMVVMSM
                     EAFEKMQFESDVYFKLAEAEREAEETGERFSSKDVLSAMKAAARGE"
     PFAM_domain     complement(1425..1622)
                     /aSDomain="PhdYeFM_antitox"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF02604.21"
                     /description="Antitoxin Phd_YefM, type II toxin-antitoxin
                     system"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_228_0023"
                     /evalue="1.80E-11"
                     /label="ctg1_228"
                     /locus_tag="ctg1_228"
                     /protein_end="71"
                     /protein_start="5"
                     /score="43.8"
                     /tool="antismash"
                     /translation="IRPVSDLRNNFADISKTVHETAQPVFLTKNGYGDMVVMSMEAFEK
                     MQFESDVYFKLAEAEREAEET"
     aSDomain        complement(1482..1616)
                     /aSDomain="TIGR01552"
                     /aSTool="tigrfam"
                     /description="phd_fam: prevent-host-death family protein"
                     /detection="hmmscan"
                     /domain_id="TIGRFam_ctg1_228_0003"
                     /evalue="1.60E-08"
                     /identifier="TIGR01552"
                     /label="ctg1_228"
                     /locus_tag="ctg1_228"
                     /protein_end="52"
                     /protein_start="7"
                     /score="31.7"
                     /tool="antismash"
                     /translation="PVSDLRNNFADISKTVHETAQPVFLTKNGYGDMVVMSMEAFEKMQ
                     "
     CDS             complement(1693..3219)
                     /locus_tag="ctg1_229"
                     /transl_table=11
                     /translation="MTTVTIIQPTISEEQNHKLRCAAYCRVSSNSEDQLNSFMAQTRYY
                     EKAFEKSDREQLVDIYADEGITGTREDKRDEFQRMISDCRKGKIDRIYTKSISRFARNT
                     KDCLKNIRELKSLGITVFFEKENIDTAKLTDEMMITIMGGLAQEESVSISKNLKWSYQK
                     RFEKGIVNVFSAPFGFKLNNGALIIDKIQAQIVEEIFDMFLNGIGYQRISEICQSKYKV
                     YKDKFSYYGIRYILSNEKYIGDSVYQKTFTTNNLPYRKIQNNGQLNKYCIQNTHEAIIS
                     IEIFEKAQKLIESRKHKNIVSESPFRGKLICANCGTKYKRKDSRNKIYWVCRKHDNLAE
                     LCMNKRVEEKFIKQSFIRLYNKLLFNYKQILVPLQTSLQDLKLKKFNGKTQVMDIHKEI
                     AKLREQTHVLARLKTKGFLDEAKYIEQTTELTAKINKLQAELKKLTRLDDEDETLDQIE
                     MLIDFFERRDKPITEFEESAFESIVEKIVVIDQHELEFHLIGGIKFKENI"
     PFAM_domain     complement(2146..2307)
                     /aSDomain="Zn_ribbon_recom"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF13408.8"
                     /description="Recombinase zinc beta ribbon domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_229_0026"
                     /evalue="6.40E-09"
                     /label="ctg1_229"
                     /locus_tag="ctg1_229"
                     /protein_end="358"
                     /protein_start="304"
                     /score="36.3"
                     /tool="antismash"
                     /translation="PFRGKLICANCGTKYKRKDSRNKIYWVCRKHDNLAELCMNKRVEE
                     KFIKQSFIR"
     PFAM_domain     complement(2335..2646)
                     /aSDomain="Recombinase"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF07508.15"
                     /description="Recombinase"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_229_0025"
                     /evalue="8.50E-15"
                     /label="ctg1_229"
                     /locus_tag="ctg1_229"
                     /protein_end="295"
                     /protein_start="191"
                     /score="55.1"
                     /tool="antismash"
                     /translation="QAQIVEEIFDMFLNGIGYQRISEICQSKYKVYKDKFSYYGIRYIL
                     SNEKYIGDSVYQKTFTTNNLPYRKIQNNGQLNKYCIQNTHEAIISIEIFEKAQKLIESR
                     "
     PFAM_domain     complement(2716..3156)
                     /aSDomain="Resolvase"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00239.23"
                     /description="Resolvase, N terminal domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_229_0024"
                     /evalue="1.90E-30"
                     /label="ctg1_229"
                     /locus_tag="ctg1_229"
                     /protein_end="168"
                     /protein_start="21"
                     /score="105.9"
                     /tool="antismash"
                     /translation="AAYCRVSSNSEDQLNSFMAQTRYYEKAFEKSDREQLVDIYADEGI
                     TGTREDKRDEFQRMISDCRKGKIDRIYTKSISRFARNTKDCLKNIRELKSLGITVFFEK
                     ENIDTAKLTDEMMITIMGGLAQEESVSISKNLKWSYQKRFEKG"
     CDS             complement(3291..3410)
                     /locus_tag="ctg1_230"
                     /transl_table=11
                     /translation="MLGFIIGLIIGGTVGVFAMALCITAGQADKRENCTDSDK"
     PFAM_domain     complement(3321..3410)
                     /aSDomain="DUF3789"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF12664.9"
                     /description="Protein of unknown function (DUF3789)"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_230_0027"
                     /evalue="8.50E-10"
                     /label="ctg1_230"
                     /locus_tag="ctg1_230"
                     /protein_end="30"
                     /protein_start="0"
                     /score="38.2"
                     /tool="antismash"
                     /translation="MLGFIIGLIIGGTVGVFAMALCITAGQADK"
     CDS             complement(3423..3581)
                     /locus_tag="ctg1_231"
                     /transl_table=11
                     /translation="MTKFGQAEYNDFMARIFADKLDKLLKESEKHNYINRNTEDIYKEF
                     ASSKDAA"
     CDS             complement(3574..3921)
                     /locus_tag="ctg1_232"
                     /transl_table=11
                     /translation="MLIKRGDIFYADLDPVVGSEQGGIRPVLIVQNNVGNKYSPTLVVL
                     PLSTAQKNHLPTHIHIKGSKALPKDSIVLAEQIRTIDRYRLKNYVGSVDLELMEKVEKA
                     MKISIGVDFDD"
     PFAM_domain     complement(3598..3912)
                     /aSDomain="PemK_toxin"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF02452.19"
                     /description="PemK-like, MazF-like toxin of type II
                     toxin-antitoxin system"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_232_0028"
                     /evalue="1.50E-31"
                     /label="ctg1_232"
                     /locus_tag="ctg1_232"
                     /protein_end="108"
                     /protein_start="3"
                     /score="109.1"
                     /tool="antismash"
                     /translation="KRGDIFYADLDPVVGSEQGGIRPVLIVQNNVGNKYSPTLVVLPLS
                     TAQKNHLPTHIHIKGSKALPKDSIVLAEQIRTIDRYRLKNYVGSVDLELMEKVEKAMKI
                     S"
     CDS             complement(3902..4138)
                     /locus_tag="ctg1_233"
                     /transl_table=11
                     /translation="MSEKVKPEKSDFRYEYNKFGVYIPAPTIRLSDKHPCCGCVWYVRD
                     TNVLFCPFHSCIRNKKVFETLKKKVKENADQTR"
     CDS             4193..4654
                     /locus_tag="ctg1_234"
                     /transl_table=11
                     /translation="VQTAFNSFCLRPIHFVSDVFRNIYPRYPLRRNSAGNRQRIDLMGV
                     SPALLAPTGKYHYPHTFHRLFGKLFRILKRHIYRSSFRSLGVWFLWLPRFHTSRVINVL
                     AELIFYCQVTWSFYSPYTCIGVEVWYLTTVFYCDLKSLLSLHKILRFFL"
     CDS             complement(4597..5031)
                     /locus_tag="ctg1_235"
                     /transl_table=11
                     /translation="MSKNIVSVYDTITKRYVEIEVSEKIRTYYNRTQWNIDDNNKSFYK
                     HEIQFSALKGNINGELENFQEFRTENDDVERRVIQNIKCEKLYSCLNELSEDERRLIFA
                     IYFENKTENEVACFLHTTQQNIHKKKRRILCKLNKLLRSQ"
     PFAM_domain     complement(4630..4779)
                     /aSDomain="Sigma70_r4_2"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF08281.14"
                     /description="Sigma-70, region 4"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_235_0029"
                     /evalue="1.10E-06"
                     /label="ctg1_235"
                     /locus_tag="ctg1_235"
                     /protein_end="134"
                     /protein_start="84"
                     /score="28.3"
                     /tool="antismash"
                     /translation="EKLYSCLNELSEDERRLIFAIYFENKTENEVACFLHTTQQNIHKK
                     KRRIL"
     CDS             complement(5517..5879)
                     /locus_tag="ctg1_236"
                     /transl_table=11
                     /translation="MTDKLRFGQFISEKRIQHSMTKQELARQIGISTAYLSQLESGARS
                     NPTIEVLDRMINKLHLDEAETHKIYDLYAASNDTISPDIITYLKSNNIVTKAIRKAQEN
                     SATEKDWLDFIDQLQK"
     PFAM_domain     complement(5688..5849)
                     /aSDomain="HTH_3"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF01381.24"
                     /description="Helix-turn-helix"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_236_0030"
                     /evalue="1.20E-12"
                     /label="ctg1_236"
                     /locus_tag="ctg1_236"
                     /protein_end="64"
                     /protein_start="10"
                     /score="47.8"
                     /tool="antismash"
                     /translation="ISEKRIQHSMTKQELARQIGISTAYLSQLESGARSNPTIEVLDRM
                     INKLHLDEA"
     CDS             complement(5892..5996)
                     /locus_tag="ctg1_237"
                     /transl_table=11
                     /translation="MTINAWRASNVKNFDQYTELYDFAGVSVFKIVVQ"
     CDS             complement(6206..6601)
                     /locus_tag="ctg1_238"
                     /transl_table=11
                     /translation="MKKQVKSSNVFGEKQKRIIAKTLINLRELNFLTQTDIAKQLHLFS
                     STISHYEKGLTVPPTEVVYRLADFYNVTTDYILGKSASRTNLNDTYAIKLTNKMTIGDA
                     VEIMAKMDNAEREHLAYFIEVIGKSKK"
     PFAM_domain     complement(6371..6526)
                     /aSDomain="HTH_3"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF01381.24"
                     /description="Helix-turn-helix"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_238_0031"
                     /evalue="1.80E-09"
                     /label="ctg1_238"
                     /locus_tag="ctg1_238"
                     /protein_end="77"
                     /protein_start="25"
                     /score="37.6"
                     /tool="antismash"
                     /translation="LRELNFLTQTDIAKQLHLFSSTISHYEKGLTVPPTEVVYRLADFY
                     NVTTDYI"
     CDS             6769..7497
                     /locus_tag="ctg1_239"
                     /transl_table=11
                     /translation="MLRVAICDDNNVFVNKMSQAVKSEFTRQNNEDIELETYVSSELMF
                     QHHLIKPFDVIFLDIDMPELDGFQLAAKISGSNDCYIIFVTSHPELVYDSLYFRPLNFI
                     TKSNDSFFTDKLHSVVNQLYNEMKQNTIIILENKEVGRVPLQIKSIYYIESSKHYVIYH
                     SEHNEPIKIRGNIGELEIHFSQYDFARIHKSFLVNLRHIFNIDRNKDEIIFKQGFRLNM
                     SKNYKQTVDEKLTQYLRKTK"
     PFAM_domain     6778..7047
                     /aSDomain="Response_reg"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00072.26"
                     /description="Response regulator receiver domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_239_0032"
                     /evalue="1.20E-10"
                     /label="ctg1_239"
                     /locus_tag="ctg1_239"
                     /protein_end="93"
                     /protein_start="3"
                     /score="41.7"
                     /tool="antismash"
                     /translation="VAICDDNNVFVNKMSQAVKSEFTRQNNEDIELETYVSSELMFQHH
                     LIKPFDVIFLDIDMPELDGFQLAAKISGSNDCYIIFVTSHPELVY"
     PFAM_domain     7195..7470
                     /aSDomain="LytTR"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF04397.17"
                     /description="LytTr DNA-binding domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_239_0033"
                     /evalue="2.10E-18"
                     /label="ctg1_239"
                     /locus_tag="ctg1_239"
                     /protein_end="234"
                     /protein_start="142"
                     /score="66.5"
                     /tool="antismash"
                     /translation="VPLQIKSIYYIESSKHYVIYHSEHNEPIKIRGNIGELEIHFSQYD
                     FARIHKSFLVNLRHIFNIDRNKDEIIFKQGFRLNMSKNYKQTVDEKL"
     CDS             7494..8801
                     /locus_tag="ctg1_240"
                     /transl_table=11
                     /translation="MKNLLWKCFELVINYYQGFIMTWFVYRFLNPKSLKQAKTFLSIFS
                     IIFGTTITLLNHITLYEGFTSTLYLVILLVYAIIAFNDSIIKKLLSTIIPNIILLLITS
                     VELNLLSSLNRISVKDLITNDNSVRFMTLIVIQISLWISLKIIIKLFKFSDSYTISDWS
                     PIITVLISSFILVSLLHVLSLNADDTQRIYINLSYLVIIILNFLMFYVIYSLFFKNAQI
                     KNMKVLSVKEQYMEQYVNNAETQYEMIRKIRHDIKDQLTTVYELLTSGKTEDALEFIEQ
                     SNGIVKATMTFVQTNNPVANAIINSKLSTASTLGIKVSCITVNDFVGINELDLCDLLSN
                     TLENAITACEAMPPDLNKFIYLEISKENNIYTFIVKNSLDKSVISENPKLKTTKKDIIN
                     HGLGTSIIRDIVNKYSGRYDYYEIDNAFCCSIILET"
     PFAM_domain     8478..8792
                     /aSDomain="HATPase_c_5"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF14501.8"
                     /description="GHKL domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_240_0034"
                     /evalue="6.40E-21"
                     /label="ctg1_240"
                     /locus_tag="ctg1_240"
                     /protein_end="433"
                     /protein_start="328"
                     /score="74.2"
                     /tool="antismash"
                     /translation="INELDLCDLLSNTLENAITACEAMPPDLNKFIYLEISKENNIYTF
                     IVKNSLDKSVISENPKLKTTKKDIINHGLGTSIIRDIVNKYSGRYDYYEIDNAFCCSII
                     L"
     CDS             8924..9499
                     /gene_functions="biosynthetic (rule-based-clusters)
                     cyclic-lactone-autoinducer: AgrB"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg1_241"
                     /sec_met_domain="AgrB (E-value: 1.7e-39, bitscore: 132.1,
                     seeds: 181, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNYLVSQIVNFITEQDVISDESDVQDFYRYGIEISISSLLNIVLV
                     VIAGILIHHIIESIVFLTLFILIRSFTGGYHADTYFRCNLLMCTTFILTALANSIFSNK
                     FSLLIIIVLICVTELIVSILGPIENKNKPIDDSKRIKLKIIGIVITLIINCTGLFLSRS
                     YLGTMIILTTFLIALLMIAAKIKERGSD"
     PFAM_domain     8942..9466
                     /aSDomain="AgrB"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF04647.17"
                     /description="Accessory gene regulator B"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_241_0035"
                     /evalue="1.40E-38"
                     /label="ctg1_241"
                     /locus_tag="ctg1_241"
                     /protein_end="181"
                     /protein_start="6"
                     /score="132.2"
                     /tool="antismash"
                     /translation="QIVNFITEQDVISDESDVQDFYRYGIEISISSLLNIVLVVIAGIL
                     IHHIIESIVFLTLFILIRSFTGGYHADTYFRCNLLMCTTFILTALANSIFSNKFSLLII
                     IVLICVTELIVSILGPIENKNKPIDDSKRIKLKIIGIVITLIINCTGLFLSRSYLGTMI
                     ILTTFLIALLMI"
     CDS             9899..10303
                     /locus_tag="ctg1_242"
                     /transl_table=11
                     /translation="MKLKKKIAAMGAAVMIMASMSAIGASAYQASYEDSYRIILAYTSY
                     TPSETDSVGTVTNLSTTKTNYSVQSTLYYKTSAAKIGSYTPSGWKKGTLSKGQLLKATT
                     THNRNTSYKYSARTLVMKDNRVFKDIQSDY"
     CDS             10510..11655
                     /locus_tag="ctg1_243"
                     /transl_table=11
                     /translation="MYTLKNLRNMMKNHTGMLVLLVISMFVSFGVLFFGVGLYYQYSKN
                     IEDGEIDSYAVGFSINDIITKKNFCEFVKNMPNKLMGDVSYITCFSSTQVSGIDEEIPV
                     AFYLQYSEGKFEYSDKVFQPMIDDLVIKDGSFFTQEQYSNGEKKAVVMGSGNVNQPTSA
                     PEYTNSVTAFGQSYDVIGTINPANSSYFFYSIYVPFSSVPDDTIMNDGVYLALNNKITK
                     SEYDDFTAYISEFFKDKITLYEPAFDLASNTSYYITVVLISVIIAILSALNISILYNYI
                     IISRTRQLTIMRICGGLTSNLSISTANEIILIMLPVSIISALCYDKFILTVLSAKFPLM
                     KAAYNPYVYAEIILIYSAISYLLNLFLLHHNLGKKIKEGLK"
     CDS             11652..12980
                     /locus_tag="ctg1_244"
                     /transl_table=11
                     /translation="MRIKLYGRVIGIFLKKHSFINVLISLQLIAVFVIGIIMTSIIDEK
                     ASSYEAVKPLLNGEGLYCGGYFLKDNENGGLLENTDEIKTQLKDVDFISSVNFASLQTG
                     VDTQTNEVKTAYALVYDDYSANLFRPTIEKGSWITDSKQSDDIPQAVITRNYQGYNVND
                     IAEFETENGTLKVRIIGVIGDNEKYLGANSEYESNEPSYQLMLSTHFNCLNDQLKNKGF
                     TNEEIALKLESLGYSADSIVYNEPVLFFTDKEWNKTDLDSVMSDSLFIKYNRNISDDEK
                     LYNRKYINENLSVLSFAIQFSQLNNNSQTIVYRELYTLMPIMCAIYLLVLIASVSVNAI
                     NCKNNIRNEAILYLGGAKRKQLLTINVIYNGLICIVSLIISIAGSLIFYKAGLFSKTVI
                     TLGWKPITICLIVCAVYILVSCIISCIILTPKALKKAIILSEE"
     CDS             12983..13654
                     /gene_functions="transport (smcogs) SMCOG1000:ABC
                     transporter ATP-binding protein (Score: 205.2; E-value:
                     2e-62)"
                     /gene_kind="transport"
                     /locus_tag="ctg1_245"
                     /transl_table=11
                     /translation="MVKLNNIVKIYNSKKANEFKALHGVSAEIRDGELIAIIGKSGAGK
                     STLLHILACIDNYQEGEYYIDDVLVKDLSESQYAKIRNEKIGMVMQDFALVEDFTALEN
                     VMIPLNFSKKKVSDKKEKALAALKSVGIEELAKKLCSKLSGGQKQRVAIARAIVNEPSM
                     ILADEPTGALDTKTSAEIMELFKSLNKQGRTVVIVTHDPKIAEQCGRVIEISDGNIVTA
                     K"
     PFAM_domain     13046..13492
                     /aSDomain="ABC_tran"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00005.29"
                     /description="ABC transporter"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_245_0036"
                     /evalue="5.40E-33"
                     /label="ctg1_245"
                     /locus_tag="ctg1_245"
                     /protein_end="170"
                     /protein_start="21"
                     /score="114.5"
                     /tool="antismash"
                     /translation="LHGVSAEIRDGELIAIIGKSGAGKSTLLHILACIDNYQEGEYYID
                     DVLVKDLSESQYAKIRNEKIGMVMQDFALVEDFTALENVMIPLNFSKKKVSDKKEKALA
                     ALKSVGIEELAKKLCSKLSGGQKQRVAIARAIVNEPSMILADEPT"
     CDS             13672..14550
                     /locus_tag="ctg1_246"
                     /transl_table=11
                     /translation="MKITDYVDLFYPSAEAEEYAKKRQKKYENYPQDFMVNLETDNIAK
                     LIAPMNFAVATSKMKEFTDDIETLDYRLDCLEDFMNVPELNGRFRQLINELAGNRIDFS
                     DVDCVNSFMQIKTHMDSLEEFLGCIENINRFFAKYNHAIKSVAVKRLAQFFEKLPKSEN
                     IFEIAYSISQLKDTFSKTIRSVKIGVNFDSAMNPDSAGLLEIGYDKIYPKGNILEKLVF
                     KSFAGREQFIGEEHFNSATRHTPIDIDTALFRELSKYTKEFALRIAAALKSYRSSVFSD
                     LSELESQYNVP"
     PFAM_domain     14622..14828
                     /aSDomain="HTH_Tnp_1"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF01527.22"
                     /description="Transposase"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_247_0037"
                     /evalue="2.80E-12"
                     /label="ctg1_247"
                     /locus_tag="ctg1_247"
                     /protein_end="69"
                     /protein_start="0"
                     /score="46.8"
                     /tool="antismash"
                     /translation="MAKRNTYTPEYKAKIVIEILEGEQTISEIASREGINVNQLKNWKK
                     EFLENASRAFNGSKSEKEAKRAAE"
     CDS             14622..14960
                     /locus_tag="ctg1_247"
                     /transl_table=11
                     /translation="MAKRNTYTPEYKAKIVIEILEGEQTISEIASREGINVNQLKNWKK
                     EFLENASRAFNGSKSEKEAKRAAENSKKREEKLMQKIGHLTVQVDWLKKKSEEVLGPDW
                     KEKSGYEE"
     CDS             14950..15783
                     /gene_functions="other (smcogs) SMCOG1026:transposase
                     (Score: 245.2; E-value: 1.2e-74)"
                     /gene_kind="other"
                     /locus_tag="ctg1_248"
                     /transl_table=11
                     /translation="MKNDRLNIKEQCELLEINRTSMYYQPVEPAEKALEREEYIKSRID
                     YWHTKFCYIGHRKIKEKLVQEDGIAIGRKLVRRYMAEMNICPVYPKSNLSKPGKNSLKF
                     PYLLKNLKIDRPNQVWSIDITYIKMGRSHMYLTAIIDWYSRFIVGYELSDTLDTAPVLA
                     AVTNAMEQYGNPEIINSDQGSQFTSNDYIEFLKAKNIRQSMDGKARWVDNVVIERWFRS
                     LKTELIYINEYSNPRELRQQIGSYIKDYNNERPHQALGYKLPVQVYQAKSVCNAA"
     PFAM_domain     15094..15222
                     /aSDomain="HTH_21"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF13276.8"
                     /description="HTH-like domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_248_0038"
                     /evalue="3.10E-07"
                     /label="ctg1_248"
                     /locus_tag="ctg1_248"
                     /protein_end="91"
                     /protein_start="48"
                     /score="30.5"
                     /tool="antismash"
                     /translation="TKFCYIGHRKIKEKLVQEDGIAIGRKLVRRYMAEMNICPVYPK"
     PFAM_domain     15292..15564
                     /aSDomain="rve"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00665.28"
                     /description="Integrase core domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_248_0039"
                     /evalue="3.20E-22"
                     /label="ctg1_248"
                     /locus_tag="ctg1_248"
                     /protein_end="205"
                     /protein_start="114"
                     /score="78.8"
                     /tool="antismash"
                     /translation="RPNQVWSIDITYIKMGRSHMYLTAIIDWYSRFIVGYELSDTLDTA
                     PVLAAVTNAMEQYGNPEIINSDQGSQFTSNDYIEFLKAKNIRQSMD"
     PFAM_domain     15550..15741
                     /aSDomain="rve_3"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF13683.8"
                     /description="Integrase core domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_248_0040"
                     /evalue="2.30E-14"
                     /label="ctg1_248"
                     /locus_tag="ctg1_248"
                     /protein_end="264"
                     /protein_start="200"
                     /score="53.0"
                     /tool="antismash"
                     /translation="RQSMDGKARWVDNVVIERWFRSLKTELIYINEYSNPRELRQQIGS
                     YIKDYNNERPHQALGYKLP"
     CDS             15804..16673
                     /locus_tag="ctg1_249"
                     /transl_table=11
                     /translation="MAIQSFRCHDNFFHLCLDKGDIIQLDFYGGAAQFISSVRARGMKM
                     CRPKFLPSEKRVTRLKNVFDLNFYRQLVTQNPQEILTEKIVANDIDMSDYARFYMVTGA
                     NNGGKTTFARAVGVCHLMAQMGLYVPAESAEISPADYIFTHFPKEEAVGINSSRFTTEI
                     KELKKICEYMTDRSLVILNESIQSTTPVECLNIAKIHLEIIAAVGVRGFYVTHLTELYN
                     EIQRINNKNYPTKVGSLVSCTDSEGKRMYKMKAAKPPIESLAYTVYEKFGAKLEDVLAK
                     SGDKNGQA"
     PFAM_domain     16101..16490
                     /aSDomain="MutS_V"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00488.23"
                     /description="MutS domain V"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_249_0041"
                     /evalue="7.50E-27"
                     /label="ctg1_249"
                     /locus_tag="ctg1_249"
                     /protein_end="229"
                     /protein_start="99"
                     /score="94.6"
                     /tool="antismash"
                     /translation="MVTGANNGGKTTFARAVGVCHLMAQMGLYVPAESAEISPADYIFT
                     HFPKEEAVGINSSRFTTEIKELKKICEYMTDRSLVILNESIQSTTPVECLNIAKIHLEI
                     IAAVGVRGFYVTHLTELYNEIQRINN"
     CDS             16627..17262
                     /locus_tag="ctg1_250"
                     /transl_table=11
                     /translation="LKTYLQSRVIRMDKRENLLQFLDYGGNELFSSLMESDSDRPQALD
                     RMCILLRKAVIFGKLKGRAAAYQYMISKANQMGFIKSKKIHAYRLTAAERERITEKVCK
                     STGAKYFFKKYGKNVIIYSALLGAAVILVVLIYNYMHSEKYLKRMYQAAEETVIIESAY
                     KTDYGIKLTIHNNSLADYYICDLPTLKYTDEYDDRAIGTYYHCKNAKL"
     CDS             complement(17386..17700)
                     /locus_tag="ctg1_251"
                     /transl_table=11
                     /translation="MADLKCVYPAVDVPSAHDAIDEFASIWDKKYPKISKSWYENRANL
                     STYFKFLQELRKLTYTTNAIEGINSKLRKVTKTKSLFPTDERLFKMLYLAQNTFMKICR
                     "
     PFAM_domain     complement(17419..17697)
                     /aSDomain="Transposase_mut"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00872.20"
                     /description="Transposase, Mutator family"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_251_0042"
                     /evalue="6.50E-19"
                     /label="ctg1_251"
                     /locus_tag="ctg1_251"
                     /protein_end="94"
                     /protein_start="1"
                     /score="68.1"
                     /tool="antismash"
                     /translation="ADLKCVYPAVDVPSAHDAIDEFASIWDKKYPKISKSWYENRANLS
                     TYFKFLQELRKLTYTTNAIEGINSKLRKVTKTKSLFPTDERLFKMLYL"
     CDS             complement(18035..18664)
                     /gene_functions="other (smcogs) SMCOG1130:transposase
                     (Score: 260.1; E-value: 4.3e-79)"
                     /gene_kind="other"
                     /locus_tag="ctg1_252"
                     /transl_table=11
                     /translation="LTGHKEVLSIHIGENESAKYWLGVLNELKNRGVKDVLVICADGLS
                     GMKEAVNTAFPQTELQRCIVHQVRNTLKYVGAKNKKEFSNDLKTIYHAPSEDAALEQLE
                     RVTEKWEKDYPNAMKSWYKNWDVISPIFKFSADVRKVIYTTIAIESLNSGYRRLNKQRS
                     VFPSDTALLKVLYLATHEIAKKWTIPLRNWGIVLGELEIMYLDRLS"
     PFAM_domain     complement(18104..18658)
                     /aSDomain="Transposase_mut"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00872.20"
                     /description="Transposase, Mutator family"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_252_0043"
                     /evalue="5.20E-55"
                     /label="ctg1_252"
                     /locus_tag="ctg1_252"
                     /protein_end="187"
                     /protein_start="2"
                     /score="186.9"
                     /tool="antismash"
                     /translation="GHKEVLSIHIGENESAKYWLGVLNELKNRGVKDVLVICADGLSGM
                     KEAVNTAFPQTELQRCIVHQVRNTLKYVGAKNKKEFSNDLKTIYHAPSEDAALEQLERV
                     TEKWEKDYPNAMKSWYKNWDVISPIFKFSADVRKVIYTTIAIESLNSGYRRLNKQRSVF
                     PSDTALLKVLYLATHEIAKKWT"
     CDS             complement(18737..18898)
                     /locus_tag="ctg1_253"
                     /transl_table=11
                     /translation="MARRKREPMSEGKKNIIAELIEEYDIRYHRPPSSADRGLAETSSG
                     RGLSHCIY"
ORIGIN
        1 ttatccctgc tttccgctgt ttgcactttc gcaggaatta tcgttacatt cggcgctgtg
       61 gacatttttc tcattccttt ccgtaatatt cttaatacgt attccgttaa taagctcaac
      121 ctctatgaca caaaaatggc ttatccaaat tcgtgaaaca cacgctttaa ataagccaat
      181 atcgagtgta tttaattgtt tgtgattctc aagcaaagcc ttgatttcct ctgttttctg
      241 cgggctgtca ttgtaagtgc agcaatcata tttcatctcg gcaagtttga aaatttcgga
      301 ttttactctg tcaaaatcca cttgcggaga atctgtcatc tgattgatct cattctgttt
      361 tcgtatcaca tccgcagtag gtgaatatgt gcttatctcg ccgcccgatt ccaacagact
      421 tggatttgct attgccgaat taataacatt aagtacagca cctatgatca tttgatctgt
      481 aatccgatat tcaagcttgt aacaatcgtg atttttgcaa tcccaatgct catactttga
      541 attgccgcct atccttgaaa gtttgtgacc gcattcggcg cagtatgtaa catttctaat
      601 ttcctgtaaa tcatcggata tcagattaag cgtggttgct tttttaaccc gcttttcatt
      661 tgcttgtctg aaaatgtcct cggcgatcaa ttgcggatat ttctcagttc caagatatct
      721 ctcattttcg attattcgct tgaccatgtt tttgttccac ttatccgaaa tagcattgta
      781 acgaattttc tctgactgca taagctttgc aatctcagac aaacttctgc ctttcagata
      841 ctcgtcaaat attgcaacaa cggcgtatac ttcttttggc tcggttgtta tctcaccgtt
      901 tttcatacag tatccgaacg ggattgtacg attctttggc attattttca ctcctttcag
      961 actacaataa tatcacattt tcttctcaaa agctattacc aatagcaaca aaaaaatgcc
     1021 ttgcaatttt acctgcaaag catttagatt cagttataac aacttttcat aatctcgtcc
     1081 ggaatacaca actctcgcta tcgttacaag ctttttatct tcgtctatcc agtaaaacat
     1141 aatataatta tgaactataa gcttacgata ctcatgcttc aaaggcttga ccggaatata
     1201 catcggacac ttatacggca tatttgccaa atcttcggca gattcaacca ttttctccgc
     1261 aagtctttca gcggcatccg gatttgcaag ctttacgccg atatattttg caatatcgac
     1321 catatcgcgt ctggcaatcg gtaaatattc aatcgtatac attattctcc tctcgccgcc
     1381 gctttcattg cgctgagaac atcctttgaa gaaaaacgtt cgcctgtttc ctcagcttct
     1441 ctttcggctt ctgcaagctt gaaatacacg tcgctttcaa actgcatttt ctcaaaagcc
     1501 tccatactca tgacaaccat atcaccgtaa ccgtttttgg taaggaaaac gggttgtgct
     1561 gtttcatgaa cggtttttga aatatccgca aaattgtttc ttagatccga aacgggtctt
     1621 atcatattca tgtccatgct catcgcctcc taaatatatt ttatcataat tatgctaaat
     1681 tgtcaatgcg ttttatatat tttctttaaa ctttattccg cctatcaagt gaaactccaa
     1741 ctcatgctga tctataacca cgatcttctc aactatactt tcaaatgccg attcttcaaa
     1801 ctcggttatc ggcttatcac gcctttcaaa aaagtctatt aacatttcga tctgatccag
     1861 agtttcgtcc tcgtcgtcta agcgtgtaag ctttttcagt tctgcttgca gcttattgat
     1921 ctttgccgta agctcagtag tctgctcaat atacttagcc tcgtccagaa aacctttagt
     1981 tttcagtctt gcaaggacgt gagtttgttc tcgaagcttg gcgatttctt tgtgaatgtc
     2041 cattacttgt gttttaccgt tgaacttttt aagtttcaaa tcctgcaatg atgtttgaag
     2101 aggtacaaga atttgcttat aattgaataa tagtttgttg tatagtctta taaaactttg
     2161 cttgataaac ttttcctcaa ctcgtttatt catgcacaat tctgctaaat tatcgtgttt
     2221 gcggcaaacc cagtatattt tatttctact atctttgcgt ttgtattttg ttccacagtt
     2281 ggcacatatc agttttcctc tgaacggtga ttcagacact atatttttat gttttctgct
     2341 ttcaatcaat ttttgagctt tttcaaatat ttctatcgaa attattgctt catgagtatt
     2401 ctgaatacaa tatttgttta attgtccatt gttttgaatc tttctatatg gaagattatt
     2461 tgttgtaaat gttttttgat agactgaatc gccaatatat ttttcgttgg aaagaatata
     2521 tcgaatgccg taataactaa atttatcttt atacactttg tacttgctct gacagatttc
     2581 tgaaattcgc tgataaccaa taccattcaa aaacatatca aaaatttctt ccacaatctg
     2641 agcttgaatt ttgtcaataa tcaatgcgcc attatttaac ttaaaaccaa atggtgcaga
     2701 aaaaacattt acaattcctt tttcaaatct tttttgataa ctccatttca agttttttga
     2761 aatggatacc gattcctcct gagccagacc gcccataatg gttatcatca tttcatcagt
     2821 cagttttgcg gtatcaatgt tttctttctc aaagaatact gttattccaa ggcttttaag
     2881 ctcccttata tttttcagac aatccttagt gtttcgggca aatcggctga tagactttgt
     2941 gtatatcctg tctatcttac ctttccgaca gtcgcttatc attcgctgaa actcatcacg
     3001 cttgtcctca cgagtacctg ttattccctc atctgcatat atgtcaacaa gctgttctct
     3061 gtcagacttt tcgaaagctt tctcgtaata tcttgtctga gccataaagg aattaagctg
     3121 atcttcgctg tttgatgaca cacggcagta tgccgcacag cggagcttat ggttttgttc
     3181 ttctgatatt gtcggctgta ttatcgttac cgttgtcatt ttctcacctc cgttttacca
     3241 acaatgatac cacaaatctt tatggaatgg tatcactata cttgataaaa ttacttatcc
     3301 gaatctgtgc agttttcacg tttgtcggct tgtcctgcgg ttatgcacaa agccattgca
     3361 aatacgccga ctgtaccgcc tatgattaat ccgataataa atcctaacat ttcaatttct
     3421 ccttaagctg cgtcttttga tgacgcaaat tctttgtata tatcttctgt atttctgttg
     3481 atgtaattat gcttttcgct ttctttaaga agtttatcaa gcttatctgc gaatatcctt
     3541 gccataaagt cgttatactc tgcctgtccg aacttagtca tcaaaatcca ctcctatgct
     3601 tattttcatc gctttttcta ctttttccat aagttcaaga tcaaccgaac ccacataatt
     3661 tttcagacga tatctgtcta tggtccgtat ctgctctgca agaacgatcg aatctttggg
     3721 caatgctttt gaacccttga tatggatatg cgtgggaaga tgattctttt gggctgtgga
     3781 cagcggaaga accacgaggg tggggctgta cttgtttccc acattattct gcactatcag
     3841 cacaggccgt atacctcctt gttccgaacc gacaacggga tcaaggtctg cgtaaaagat
     3901 atcacctcgt ttgatcagca ttttccttca cctttttctt tagagtttca aaaactttct
     3961 tattccttat acagctatga aacggacaga acagcacatt tgtatctctg acataccaca
     4021 cgcagccgca gcatggatgc ttgtccgata atctgattgt aggagcagga atatatactc
     4081 caaatttatt atattcgtac cgaaaatctg atttttcagg cttaactttt tcgctcatat
     4141 atcagcctcc tgacttttgt taatttatat gtaacaggcg gtctgcaaaa gtgtgcaaac
     4201 cgcctttaat tcgttttgcc ttcgtccgat ccattttgtt tcggacgttt tccgcaatat
     4261 ttatccccga tacccgttgc ggcggaactc tgcaggcaat cgacagcgta tcgatctcat
     4321 gggcgtttca cccgctcttt tagcccctac tgggaagtat cattatcctc acacgtttca
     4381 tcgccttttc ggaaagctgt tccgaatttt gaaacgtcac atttatcgct catcctttcg
     4441 gagtcttggc gtgtggtttc tttggctgcc gagatttcat accagccgtg tgatcaacgt
     4501 acttgcagag ttgatattct attgtcaagt tacttggagc ttttattctc cttacacttg
     4561 tataggggta gaagtctggt atttaacaac cgttttttat tgtgatctca aaagtttgtt
     4621 aagcttgcac aaaatcctac gtttcttttt gtgaatattt tgctgagtgg tatgtagaaa
     4681 acaagcgacc tcgttttccg ttttattttc aaaatatatt gcaaagatca accttcgttc
     4741 atcctctgaa agttcattca gacagctata cagcttttcg catttaatat tttgtatcac
     4801 tcttctttcg acgtcgtcat tttctgttcg gaactcctga aagttttcaa gttctccgtt
     4861 aatgtttcct ttcaacgcag agaactggat ctcgtgctta tagaacgatt tattgttgtc
     4921 atcaatattc cattgggttc tattgtaata tgtgcggatc ttttcgctta cttcaatttc
     4981 aacgtatctt ttggttatag tgtcataaac acttactatg tttttgctca ttttttattc
     5041 ctccgttttg attttcttgt tctgaatcaa aacgaaggct tatggatatt tggctatgta
     5101 ttgctgccag tatttaaaaa tgggcataaa aaaactccat ttctgctctt aaagcaaaaa
     5161 tggagttaac aaaaataaaa aaatagaaac cgacactagc tttaaaagct acttgtcagg
     5221 cttctactcc gattttaaac aaacgtgtga tgcttgtact aagtaattaa tattatttaa
     5281 tggttttaac gttattgttt ctcggcattt ccaacacttg atcataactg caaagtttgt
     5341 accgaaataa ctattctcgc cttttcctgt tattacatca aaaagtctgc caccacatat
     5401 tgggcagcgt atatgatgta tattatctat tgtcaatcta tcaatcctcc gacgtttagc
     5461 tggtaagcta aactgatgct aaataaattt gcggcataaa ccgcaaaatt atttgttcat
     5521 ttttgaagtt ggtctatgaa atcaagccaa tctttttctg ttgcactatt ttcctgtgct
     5581 ttacgaatcg cttttgttac aatattattg ctctttagat atgtaataat gtccggacta
     5641 attgtatcat ttgatgctgc atagagatca tatattttat gtgtttccgc ttcgtccaag
     5701 tgcaatttat taatcattcg gtcaagcact tcaatagttg gattgcttct tgctccgctt
     5761 tcaagttgac tgagatatgc tgtagatatc ccaatctgtc ttgcgagttc ttgcttggtc
     5821 atagagtgtt gtattcgttt ctcggatatg aactgaccga atctgagttt gtcagtcatg
     5881 ttttgtgttc tttactgaac tacgatttta aaaacagaaa cacctgcaaa atcgtacaat
     5941 tcagtatatt gatcaaaatt ttttacattt gaagctctcc aagcatttat agtcataaaa
     6001 attctcctta ttaaatttca tatgatgcat gagtcttatt taattatacg ttttacatta
     6061 tcgatgtcaa caaaattggc ataaggtgaa gatgtttagc acgaaatgca aagatcagaa
     6121 aactaacata atatgcttga ccttgttgtt ttattatggt aaaataaaaa agaaccctga
     6181 tacaaattca gagttctaaa ttgaattatt tttttgactt tcctataacc tcaatgaaat
     6241 acgctaaatg ctcacgttct gcgttgtcca tctttgccat tatttctaca gcgtcgccta
     6301 tagtcatttt atttgttagc tttattgcat aagtgtcatt aagatttgtc ctgcttgcac
     6361 ttttgccgag aatataatct gtagtaacgt tataaaagtc ggcaagtcga tacacaactt
     6421 ctgtaggtgg gacagttaaa cctttttcat agtgagaaat agtgctggaa aacagatgaa
     6481 gctgctttgc tatatctgtt tgtgttaaga aattgagttc tcgcagattg atcaatgttt
     6541 tagctataat gcgtttttgc ttttcgccaa aaacatttga actttttact tgctttttca
     6601 taatatatgc tccgcctctc tttccggttc caacactttt attatagtat aaatatagtc
     6661 cgaagtcata aatctgtatt atttataaaa atcagcgaat tttgtcgtaa aattatatca
     6721 caaatacaat tgttgtgatt tatactacat tttaaggagg aaatacatat gctcagagtg
     6781 gcaatatgtg atgataataa cgtatttgtt aataaaatgt cacaagctgt aaaatctgaa
     6841 tttacaaggc agaataatga agatattgag ttagagacct atgtttcaag cgaattaatg
     6901 ttccagcacc acttaataaa gccatttgat gtgatttttc tcgatattga tatgccggag
     6961 ctcgacggat ttcaattagc ggctaagatt tccggttcaa acgactgcta cataattttt
     7021 gttaccagtc atcccgagtt ggtttatgat agtctttatt tccgaccact taattttatt
     7081 accaaaagca atgattcttt tttcacagat aaactgcaca gtgttgttaa tcagctttac
     7141 aatgaaatga aacaaaacac aattattatt ttggaaaata aagaagtcgg aagagttccg
     7201 ctgcaaataa agagcattta ttatattgag agcagtaaac attatgttat ctatcattca
     7261 gaacataacg aaccgataaa gatcagaggt aatattggtg aattggagat tcatttttct
     7321 caatatgatt ttgctcggat acacaagagt tttctagtta atcttcgtca catttttaat
     7381 atagatagaa ataaagacga gataattttt aagcaaggct ttagattaaa tatgagtaaa
     7441 aactacaaac aaactgttga tgagaaatta acacagtatt tgaggaagac aaaatgaaga
     7501 acttgctatg gaaatgcttt gagcttgtga ttaattatta tcagggcttt attatgacat
     7561 ggtttgtgta tagatttcta aatcctaaat ctctcaaaca ggcaaaaaca tttctttcga
     7621 tttttagtat catatttgga acaaccataa ccctgttaaa tcacatcact ttatatgagg
     7681 gatttacaag tactttatat ttagttatat tgttggtata tgccattatt gcctttaacg
     7741 acagtattat taaaaaacta ctatcaacga tcattcccaa tattattctg ctgcttatca
     7801 cttctgttga acttaattta ttatcatctc taaatagaat aagcgtcaag gacttgatta
     7861 caaatgataa tagcgtaaga ttcatgactt tgattgtaat ccagatttct ctttggatct
     7921 ccttgaaaat tataatcaag ctgttcaaat tctctgacag ttatacaata tcagattggt
     7981 ctccgattat cacagtatta atatcttcct ttattctagt atcacttctc catgtacttt
     8041 cactcaatgc ggatgatacg caaagaatat acatcaattt atcatacctg gttatcatta
     8101 tactgaattt cctaatgttt tacgttattt attcactctt cttcaagaat gctcagataa
     8161 agaatatgaa ggtactatcc gtaaaagaac agtatatgga acagtatgtt aataatgcgg
     8221 agactcaata cgagatgatc agaaaaataa ggcacgatat aaaggatcaa cttaccaccg
     8281 tttatgaatt gctcacaagt ggcaaaaccg aagatgcttt ggaatttatt gaacaatcca
     8341 acggcattgt taaagctaca atgacatttg ttcaaaccaa taatccagtt gcaaatgcaa
     8401 taatcaactc taaattgtct actgcatcaa ctttaggaat aaaggtgtca tgtattacgg
     8461 taaatgactt tgtaggtatc aatgagcttg atctatgtga cttattgagc aatactttgg
     8521 aaaatgcgat cacagcctgt gaagctatgc cgccagattt aaacaagttt atctatttgg
     8581 aaatcagtaa agaaaacaac atttatacat ttatagtgaa aaattctcta gataagtctg
     8641 ttattagcga aaatccaaaa ttaaaaacca caaagaaaga tatcataaac catggacttg
     8701 gcacttctat tattagggac atagtaaata aatacagtgg aagatatgat tactatgaaa
     8761 ttgacaatgc tttctgctgc tctataatct tagaaactta actcatatga tagctcggct
     8821 tatgccgagt tatttttttg tgcctgaaaa ctgcacaata tgccaaaacg cttgacgaaa
     8881 gatattttat attgtaaaat tcaaaaaaag caaggtgaaa attatgaatt acttggtatc
     8941 tcagattgtt aattttatta cggaacaaga tgtaatcagt gatgaatcag atgtacaaga
     9001 cttttataga tatggaatag aaataagtat ttcatcgtta cttaacatag ttcttgttgt
     9061 aatagcaggt atccttattc atcatataat cgaaagtatt gtttttctta cactatttat
     9121 acttatcaga tcattcaccg gaggctatca tgccgacaca tactttaggt gcaatctatt
     9181 gatgtgtact acattcatat taaccgcttt agccaatagt atattttcta ataaattctc
     9241 cctattgatt attattgttt taatctgtgt tactgaactg atagtttcta tcttgggtcc
     9301 tatagagaat aagaataaac caattgatga ttcgaaaaga ataaagctta aaataatagg
     9361 gatagttata actttaataa ttaattgtac cggattgttt ctttcgagaa gttatctagg
     9421 tacaatgatt atattaacaa cttttttaat tgccttgctc atgattgcag caaagattaa
     9481 agagagagga agtgattaat gtgaaaagtt taaaaaaact actagctgaa atgattcaga
     9541 agattgcaaa acatacagca attttggctt gtggagcagc ttcggcatac ggtggatatc
     9601 agactaaaga gccaaagaac atctacaaga gataagcatc aaaaaacaca attcaaaaga
     9661 ttggcatatt cgactattac gatctacact agtatagttt tgagctgaat taatcatttt
     9721 gtgcaggaag aagattgatt caaaggtttt caaagtactg taatacttgt catagcaagt
     9781 atagaaattg tcttttactt tgcttaaaga tggttttttt agaatacaga ctttaggtcg
     9841 ggagtattgc gtttgtctta tgatgaaagc aataaaaaat ttcaaggagg ttttcaatat
     9901 gaaacttaag aagaaaattg cggctatggg tgctgctgtt atgataatgg cttctatgag
     9961 tgctataggt gctagtgcgt atcaagcatc atatgaggat agttatcgaa ttatacttgc
    10021 atatacgtct tatactccaa gcgagacaga ttcagtggga acggtaacga atctttcaac
    10081 tacaaaaaca aattactctg tacagtcaac cctttattac aagacttctg cagcaaaaat
    10141 cggttcttat actccttctg gatggaaaaa aggtacgctg tccaaaggtc agcttttgaa
    10201 agcaacaaca acccataacc gtaatactag ttataagtat tctgccagaa ctctagtcat
    10261 gaaagataat agagttttta aggatattca gtctgattac taatatataa ccctgaggag
    10321 ctaaagctcc tgcggcaagc ttgcttcgtc gcagccgatg aaaagctacg cttacatcgg
    10381 gctttgctcc gaattaaata tgcattaaag aaattttaat aaaaatcaat tgaacatttt
    10441 acaaaggcaa tgcattatct gaataacatc agataatgca ttgccttaat gggtttgaag
    10501 gaggaaagaa tgtacacgct gaaaaatctt agaaatatga tgaaaaatca taccggtatg
    10561 ctggttctac ttgtgatttc tatgtttgtt tcattcgggg ttttgttttt cggtgttgga
    10621 ttgtactatc agtacagcaa aaatattgag gacggcgaaa ttgacagcta tgctgtcggt
    10681 ttttccataa atgacattat tacaaaaaaa aatttttgtg agtttgtgaa gaatatgccg
    10741 aataagctta tgggtgatgt ttcatatatt acctgttttt cgtccacgca ggtaagcgga
    10801 attgatgagg aaatacctgt cgcattctat cttcagtatt ctgaaggaaa atttgaatat
    10861 tccgataaag tatttcagcc aatgattgat gaccttgtaa ttaaggacgg cagttttttc
    10921 acgcaggagc aatattcaaa cggagaaaaa aaggctgttg taatgggcag cggaaatgta
    10981 aatcagccga cttcagcacc cgaatataca aattcggtta cagcattcgg tcagagctat
    11041 gatgttatcg gcacaataaa ccctgctaac agcagctatt ttttttacag tatctatgtt
    11101 ccgttcagct cagtccccga cgatacaatt atgaacgacg gggtttatct tgcactcaac
    11161 aataaaatca ctaaatctga atatgatgat tttaccgcat atatcagcga atttttcaaa
    11221 gataaaatca ctctttatga accggcattc gacttggcat caaacacttc ctactacata
    11281 acagttgtac tgatttcggt aatcattgcc attctttcgg cattgaacat ttccattctg
    11341 tataattaca tcattatcag cagaacaaga caactgacca ttatgcgtat ctgcggaggg
    11401 ttaacctcaa atctgagcat atcaaccgca aatgagatta ttcttattat gcttcctgta
    11461 agcattattt cagctttgtg ctatgataaa tttattctta ctgtactttc agctaaattt
    11521 ccgcttatga aagctgcata taatccatat gtttacgcag aaataatttt gatttactct
    11581 gcaatatcgt atcttcttaa tctgtttttg cttcatcata atctcggcaa aaaaattaag
    11641 gagggattga aatgagaatt aagttatacg gcagggttat cggtatattc ctgaaaaagc
    11701 actcgtttat caatgtttta ataagcctcc agctgattgc tgtttttgtt atcggaataa
    11761 ttatgacatc gataatagac gaaaaggctt cctcatatga ggctgtcaaa ccgctgctta
    11821 atggcgaggg attgtattgt ggtggatatt ttttgaaaga taatgaaaat ggcggacttt
    11881 tggaaaacac agatgaaatc aaaactcagc tgaaagatgt tgattttatc tcgtctgtaa
    11941 actttgcgtc cctgcaaaca ggcgttgata cacaaactaa cgaggttaag accgcatatg
    12001 cacttgtata tgatgattat tctgcaaatc tttttcgccc gacaatagaa aaaggttcgt
    12061 ggataactga ttccaagcaa tccgatgata taccgcaggc tgtaattacc cgaaattatc
    12121 aaggctataa tgttaatgat attgctgaat ttgaaactga aaatggaacg ttgaaggtca
    12181 gaataatcgg tgtaattggt gataatgaaa aataccttgg agcaaactcg gaatatgaat
    12241 caaatgaacc atcctatcag ttaatgcttt ctacacattt caactgtctg aatgaccagc
    12301 ttaaaaacaa aggctttaca aacgaggaga ttgctttgaa actcgaatct cttgggtatt
    12361 cagcggacag cattgtatat aatgaacctg tattgttttt tacagataag gagtggaata
    12421 aaaccgattt ggattcagta atgtcagact ccctttttat aaagtacaac cggaatattt
    12481 ccgatgatga aaagctttac aacagaaaat atatcaacga gaatctttct gtattatcat
    12541 ttgcgataca gttttctcag ttgaacaaca acagtcagac cattgtttat agagagttgt
    12601 acacattgat gccaataatg tgtgcaatat acctgcttgt actgattgcg tcagtgagcg
    12661 ttaatgcgat taactgcaaa aataatataa gaaacgaagc catactgtat ttgggtggtg
    12721 caaaaagaaa acagttgctt acaatcaatg taatttacaa tgggctgatt tgcattgtgt
    12781 ctttgataat ttcaatagca ggatcgttga ttttctacaa ggcaggattg ttcagcaaaa
    12841 cagtaattac attgggctgg aaaccgatca ccatttgcct gattgtgtgt gctgtatata
    12901 tcttggtatc ctgtatcatt tcctgcatta tcctcacacc aaaggctttg aaaaaagcaa
    12961 taatattatc ggaggaatag taatggtaaa acttaataac atagtaaaaa tatataattc
    13021 aaagaaagcc aacgaattca aggctctcca cggtgtttcg gcagaaattc gggacggtga
    13081 gcttattgcg attatcggaa aatcgggtgc aggaaaatca acgcttctgc atattttagc
    13141 ctgcattgac aactatcagg agggcgaata ctacattgat gatgtgcttg tgaaagacct
    13201 ttccgaaagt cagtatgcaa aaatcagaaa cgagaaaatc gggatggtta tgcaggattt
    13261 tgcactggtt gaggatttca cggcactgga aaacgtgatg ataccgctga atttttccaa
    13321 aaagaaagtc agtgacaaga aagaaaaagc ccttgcggca ctgaaatcgg taggcattga
    13381 ggagcttgcc aaaaagctat gcagcaaact ttcgggcgga cagaagcagc gtgtggcaat
    13441 tgccagagcg atagtcaatg aaccgtcaat gattttggcg gacgaaccga cgggagcgct
    13501 ggacacaaag acttccgctg agattatgga gcttttcaag tccctgaaca aacagggcag
    13561 gacggttgtt atagttaccc acgacccgaa gattgcggag caatgcggca gggttattga
    13621 gattagtgac gggaatattg ttacagcaaa ataaattgtg gagtgaaaac aatgaaaatt
    13681 accgattatg tagatctgtt ctatccgtcg gcggaggctg aggagtatgc aaaaaagcgg
    13741 cagaaaaaat atgaaaatta tccgcaggat tttatggtca atcttgaaac ggataacata
    13801 gcaaaactta ttgcacctat gaattttgct gtcgcaacat ctaaaatgaa agagtttaca
    13861 gatgacattg aaacccttga ttacaggctg gattgtcttg aggactttat gaatgtcccc
    13921 gaacttaacg gaagatttcg acagctgata aatgaactcg caggaaacag aattgacttt
    13981 tcagatgttg attgtgtcaa ctcgtttatg cagattaaga cccatatgga cagccttgaa
    14041 gaatttctcg gctgcattga aaacatcaac aggttctttg caaagtataa tcacgcaatt
    14101 aagtcggtag cggtaaaaag gcttgcacag ttttttgaaa aactgccaaa aagcgagaac
    14161 attttcgaaa tagcatacag catttcacag ctgaaagata ccttttcaaa aaccatacgg
    14221 agcgtaaaaa tcggtgttaa ttttgattcg gctatgaatc ccgacagtgc aggactgctt
    14281 gaaatcggat atgacaaaat ttatcccaag ggaaatattc ttgaaaagct tgtgttcaaa
    14341 agttttgcag gcagagagca gtttattggc gaggagcatt tcaactcggc aacaaggcac
    14401 actcctattg atatagacac tgcccttttc cgtgaactga gcaaatacac aaaggagttc
    14461 gccctgcgga ttgccgcagc acttaaaagc tatcgttcct cggttttttc agacctttcg
    14521 gagctggaat cacagtataa tgtaccctag aaactgaaca caaaattgcc aaaacatcgt
    14581 gacagtggta taataaaaga aagaaacagg aggacacgat aatggcgaag aggaacacat
    14641 acacaccgga gtacaaggca aaaatcgtaa tagaaatact ggagggagag cagacgatca
    14701 gcgagatagc aagtcgtgaa ggaatcaacg tcaatcagct gaaaaattgg aaaaaggaat
    14761 ttcttgagaa tgcatcccgt gcctttaatg gttcaaaatc agaaaaggaa gcaaaaagag
    14821 cagctgagaa ctcaaaaaag cgggaagaaa agcttatgca gaaaatcggt cacctgacag
    14881 ttcaggtgga ctggctcaaa aaaaaatctg aagaagtgct cggacctgac tggaaggaaa
    14941 agtctggtta tgaagaatga taggctgaac attaaggaac agtgtgaact gcttgaaatc
    15001 aaccgcactt cgatgtacta tcagcctgtt gaaccggcag aaaaagcctt ggagcgtgag
    15061 gaatacatca aatcacgtat tgactactgg cacacaaaat tctgctacat tggtcatcgg
    15121 aaaatcaaag aaaagcttgt acaggaagac gggattgcaa tcggcagaaa gcttgtcaga
    15181 cgttatatgg cggaaatgaa tatctgtccg gtttatccga aatccaatct ttcaaagccc
    15241 ggaaagaaca gtttaaaatt tccgtatctg ctgaaaaatc taaaaattga ccgaccaaat
    15301 caggtatggt caattgacat cacctatatc aaaatggggc gtagccatat gtatctgaca
    15361 gcgattattg attggtacag ccgttttatc gtgggctatg aattgtctga tacgctggat
    15421 actgcaccgg ttttagcagc agtcacaaat gccatggaac aatacggcaa tcctgaaatt
    15481 atcaattctg atcagggcag ccagtttaca agcaatgact atattgaatt tctgaaagcg
    15541 aagaatatcc gccagagtat ggacggaaaa gctagatggg tggataatgt ggtaattgaa
    15601 cgctggtttc gcagcttgaa aacggagttg atttatatca atgaatacag caatcccaga
    15661 gagctgcgcc agcagattgg tagttacatc aaggattaca acaacgaaag accccatcag
    15721 gcgcttggct acaagttgcc tgtgcaggtt taccaagcca agtctgtatg caatgctgca
    15781 taaattttgc ttacgttttt tggatggcta tacaaagttt tcgctgtcac gataattttt
    15841 ttcatttgtg tcttgacaag ggggacatta tacagcttga cttctatggc ggagcggcac
    15901 agtttatatc aagtgttagg gcaaggggaa tgaaaatgtg ccgaccgaaa tttctcccct
    15961 ctgagaagcg tgttacaagg ctgaaaaacg tctttgacct caacttctac aggcagcttg
    16021 ttacgcaaaa tccgcaggaa attctgaccg aaaaaattgt tgcaaacgat attgatatgt
    16081 cagattacgc acggttttat atggtgacgg gagcaaacaa cggcggaaaa accactttcg
    16141 caagagcggt gggagtatgt catttaatgg cacaaatggg attgtacgtt cctgcggaaa
    16201 gtgcagagat ttcccctgcc gattacatat tcacccattt tccaaaggaa gaagctgtcg
    16261 gaataaattc aagccgattt accacggaaa tcaaggagct gaaaaaaatc tgcgaatata
    16321 tgaccgacag aagtcttgtt attctcaacg aatccattca gtcaaccacg ccagttgagt
    16381 gcttaaacat tgcaaaaatt catcttgaaa ttatagcggc agtgggggta aggggatttt
    16441 atgtcactca tctaacagaa ctttataatg aaattcagcg gataaacaac aaaaactatc
    16501 ccacaaaggt gggaagtctg gtatcctgca cagacagtga gggcaagcgt atgtacaaga
    16561 tgaaagccgc aaagccgcct attgaaagtc ttgcatacac ggtttacgaa aaattcggag
    16621 caaagcttga agacgtactt gcaaagtcgg gtgataagaa tggacaagcg tgaaaacctt
    16681 ttgcagtttc ttgattacgg tggaaacgag ctgttttcaa gccttatgga aagtgacagc
    16741 gacagaccgc aggcgttgga cagaatgtgc attttacttc gcaaggctgt gattttcggg
    16801 aaactgaaag gcagagctgc ggcataccaa tatatgattt caaaggcaaa ccaaatggga
    16861 tttataaagt caaaaaaaat acatgcctac aggctgacag ctgccgaacg ggagcggatt
    16921 acagaaaaag tctgcaagtc aacaggtgcg aaatattttt tcaaaaagta tggaaagaac
    16981 gtgataattt attctgcact gcttggggcg gctgtgattt tggttgtgct gatatataat
    17041 tatatgcact cggaaaaata tctgaaaaga atgtaccagg cggctgagga aactgtaatt
    17101 atagagtcgg catacaaaac cgattacggc ataaagctta ccatacacaa caattcactt
    17161 gcggactatt acatctgcga tttgccgacc ttgaaatata ctgacgaata tgatgaccgg
    17221 gcaatcggaa catattatca ttgtaaaaat gcaaaacttt aagattgtgt tatatacaag
    17281 tttgacaaaa aatgacctga ttctaaattc tgtatagctg cggaatggca tatcaaaatt
    17341 aaagagcaaa tctatttgat gagatcgtcg aaaccaccgt cggtcttatc tgcatatttt
    17401 cataaaagta ttctgtgcaa gatacagcat tttgaacagt ctctcatcgg ttggaaataa
    17461 cgactttgtt ttggtgacct ttcgcagctt actgttaatt ccctcaatcg cattggtagt
    17521 gtaagtcagc tttctcagtt cctgcagaaa cttgaagtaa gtgcttagat tcgcccgatt
    17581 ttcataccat gactttgaaa tctttggata cttcttgtcc catattgatg caaattcgtc
    17641 aatggcatca tgcgcagaag gcacatcaac agcgggataa acacatttta aatcagccat
    17701 aagttctttc tgacacgctc agacctaaat attgcggata tgctcttcaa tgtcagcagt
    17761 tgacacacct tttgcgtaac attgagatga ttttattctc catgtccgaa gaaattttgg
    17821 gctgattttt ccaaataagc tgcagctctg gccctgcgaa aaaatctctg taaattcaac
    17881 aacagtgata aaaaacgata ttgtggagcg gcttgaaaaa cagccgctca tttttttaca
    17941 gtatacaata aataccgtaa tttgtcaagg ttcttcaaca gtcagtctgc tggaatggag
    18001 cgtagcggaa tggaagcaga ctgactgtgc cggctcagct tagcctgtcg agatacatga
    18061 tctccagctc gccaagaact atgccccagt ttctcagcgg tatagtccat tttttcgcta
    18121 tttcatgcgt tgcaagatac agtaccttca ggagcgccgt atcgctcgga aatacgcttc
    18181 tctgcttgtt cagacgacga tagccgctgt taaggctttc gatcgcaatg gtggtgtaaa
    18241 tgacctttct cacatcagcg gaaaacttga agatcggtga gatcacatcc cagtttttgt
    18301 accagctctt catggcgttt ggataatctt tctcccactt ctccgtcaca cgctcaagct
    18361 gttcaagcgc agcgtcctca gacggtgcgt gataaatggt tttcaaatcg ttggaaaatt
    18421 ctttcttgtt ttttgcacca acatatttca gcgtgtttct tacttgatga acgatacaac
    18481 gctgtaattc tgtctgtgga aatgccgtat ttacggcttc tttcataccc gaaagaccat
    18541 cggcacatat cacgaggaca tcctttacgc cgcgattttt cagctcattc aggactccaa
    18601 gccaatattt tgcactttcg ttttctccga tatgtatgga taaaacttcc ttgtgacctg
    18661 tcaaacttac tgcaaggatt acatatgctg caagtttttt atctgtccgt tttctcgtac
    18721 agaaaaatgt acagcatcaa taaatacaat gagataaacc tcgcccagag gacgtttctg
    18781 ccagtcctct atctgcggaa gaaggcggtc tgtgatatcg gatatcatac tcctcgatca
    18841 gctctgcgat gatattcttc ttcccctcgc tcattggttc tctttttctt cttgccat
//
