LOCUS       NZ_CP016337.1          10624 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  NZ_CP016337.1 Kosakonia sacchari strain BO-1 chromosome, complete
            genome.
ACCESSION   NZ_CP016337
VERSION     NZ_CP016337.1
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 6.1.1
            Run date     :: 2024-03-14 15:34:12
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 3170694
            Orig. end    :: 3181318
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..10624
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[3175694:3176318](+)"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193)"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      5001..5624
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193)"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
     cand_cluster    1..10624
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193)"
                     /kind="single"
                     /product="RiPP-like"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..10624
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="RiPP-like"
                     /region_number="4"
                     /rules="(strepbact or Antimicrobial14 or Bacteriocin_IId or
                     BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or
                     Lactococcin or Antimicrobial17 or Lactococcin_972 or
                     Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or
                     TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or
                     TIGR03975 or DUF692 or TIGR01193)"
                     /tool="antismash"
     CDS             2379..2555
                     /locus_tag="ctg1_3008"
                     /transl_table=11
                     /translation="MAFLRFYAVKFMPAMLVFCFMFQASTLHVKQAVSTSKLIHLPNPA
                     HNKRDYLLNIIQV"
     CDS             complement(2490..2999)
                     /locus_tag="ctg1_3009"
                     /transl_table=11
                     /translation="MIPLLAIAAWSGTGKTTLLKKLIPALCEQGIRPGLIKHTHHDMDV
                     DKPGKDSYELRKAGAAQTLVASSQRWALMTETPDEAELDLAYLISRMDATKLDLVLIEG
                     FKHEPVPKILLWRHDCGHDLAELVLDEHVIAIASDIPLMHGVPVLNLNDIEQIVTFIMR
                     WIRQVD"
     aSDomain        complement(2508..2987)
                     /aSDomain="TIGR00176"
                     /aSTool="tigrfam"
                     /description="mobB: molybdopterin-guanine dinucleotide
                     biosynthesis protein B"
                     /detection="hmmscan"
                     /domain_id="TIGRFam_ctg1_3009_0034"
                     /evalue="1.40E-51"
                     /identifier="TIGR00176"
                     /label="ctg1_3009"
                     /locus_tag="ctg1_3009"
                     /protein_end="164"
                     /protein_start="4"
                     /score="172.6"
                     /tool="antismash"
                     /translation="LAIAAWSGTGKTTLLKKLIPALCEQGIRPGLIKHTHHDMDVDKPG
                     KDSYELRKAGAAQTLVASSQRWALMTETPDEAELDLAYLISRMDATKLDLVLIEGFKHE
                     PVPKILLWRHDCGHDLAELVLDEHVIAIASDIPLMHGVPVLNLNDIEQIVTFIMRW"
     PFAM_domain     complement(2583..2987)
                     /aSDomain="MobB"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF03205.16"
                     /description="Molybdopterin guanine dinucleotide synthesis
                     protein B"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_3009_0134"
                     /evalue="1.60E-49"
                     /label="ctg1_3009"
                     /locus_tag="ctg1_3009"
                     /protein_end="139"
                     /protein_start="4"
                     /score="167.4"
                     /tool="antismash"
                     /translation="LAIAAWSGTGKTTLLKKLIPALCEQGIRPGLIKHTHHDMDVDKPG
                     KDSYELRKAGAAQTLVASSQRWALMTETPDEAELDLAYLISRMDATKLDLVLIEGFKHE
                     PVPKILLWRHDCGHDLAELVLDEHVIAIASD"
     CDS             complement(2996..3583)
                     /locus_tag="ctg1_3010"
                     /transl_table=11
                     /translation="VTDSSAVTGVVLAGGKASRMGGKDKGLQELNGKPLWQHVAERLAP
                     QVTSLVISANRNLEIYRTSGLPVLTDTLDDFPGPLAGILSVMQQSNEEWFLFCPCDTPR
                     IPTDLMTRLQKNRQHNAPAMWVNDGERDHPAIALVHRSVLPFLQDYLTSGERRVMVFMR
                     RAGGHAVDFSDVKSAFANVNTPDDLAHWQERI"
     aSDomain        complement(3017..3565)
                     /aSDomain="TIGR02665"
                     /aSTool="tigrfam"
                     /description="molyb_mobA: molybdenum cofactor
                     guanylyltransferase"
                     /detection="hmmscan"
                     /domain_id="TIGRFam_ctg1_3010_0035"
                     /evalue="1.00E-71"
                     /identifier="TIGR02665"
                     /label="ctg1_3010"
                     /locus_tag="ctg1_3010"
                     /protein_end="189"
                     /protein_start="6"
                     /score="238.8"
                     /tool="antismash"
                     /translation="VTGVVLAGGKASRMGGKDKGLQELNGKPLWQHVAERLAPQVTSLV
                     ISANRNLEIYRTSGLPVLTDTLDDFPGPLAGILSVMQQSNEEWFLFCPCDTPRIPTDLM
                     TRLQKNRQHNAPAMWVNDGERDHPAIALVHRSVLPFLQDYLTSGERRVMVFMRRAGGHA
                     VDFSDVKSAFANVNTPDDLA"
     PFAM_domain     complement(3104..3559)
                     /aSDomain="NTP_transf_3"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF12804.9"
                     /description="MobA-like NTP transferase domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_3010_0135"
                     /evalue="8.10E-32"
                     /label="ctg1_3010"
                     /locus_tag="ctg1_3010"
                     /protein_end="160"
                     /protein_start="8"
                     /score="110.8"
                     /tool="antismash"
                     /translation="GVVLAGGKASRMGGKDKGLQELNGKPLWQHVAERLAPQVTSLVIS
                     ANRNLEIYRTSGLPVLTDTLDDFPGPLAGILSVMQQSNEEWFLFCPCDTPRIPTDLMTR
                     LQKNRQHNAPAMWVNDGERDHPAIALVHRSVLPFLQDYLTSGERRVMV"
     PFAM_domain     3653..3910
                     /aSDomain="DUF1040"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF06288.15"
                     /description="Protein of unknown function (DUF1040)"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_3011_0136"
                     /evalue="2.90E-45"
                     /label="ctg1_3011"
                     /locus_tag="ctg1_3011"
                     /protein_end="86"
                     /protein_start="0"
                     /score="152.6"
                     /tool="antismash"
                     /translation="MKCKRLNEVIELLQPAWQKEPELNLVQFLQKLAQESGYQGDLVDL
                     SDDILIYHLKMRDSSKDAVIPGIQKDYEEDFKTALLRARGV"
     CDS             3653..3922
                     /locus_tag="ctg1_3011"
                     /transl_table=11
                     /translation="MKCKRLNEVIELLQPAWQKEPELNLVQFLQKLAQESGYQGDLVDL
                     SDDILIYHLKMRDSSKDAVIPGIQKDYEEDFKTALLRARGVIKE"
     CDS             3998..4984
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) APH"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg1_3012"
                     /sec_met_domain="APH (E-value: 5.6e-43, bitscore: 145.7,
                     seeds: 156, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTCNAFTFQTLHPDTIMDALFEQGIRVDSGLTPLNSYENRVYQFQ
                     DEDRKRYVVKFYRPERWSAEQIREEHEFALDLQRDDVPVAAPLAFNNETLLTHQDFFFA
                     VFPSVGGRQFEADNLDQMEWVGRYLGRMHQTGSKKHFTSRPEIGVQEYLIEPRQLFETS
                     TLIPSGFKDEFLRAADKLIDAVMAQWHNRFNLLRLHGDCHAGNILWRDGPMFVDLDDAR
                     NGPAIQDLWMLLHGDKAEQRMQLEMIVEAYEEFSEFNVAELALIEPLRAMRLVYYLAWL
                     IRRWDDPAFPKNFPWLSSEDHWHRQTLIFLEQVKVLQEPPLALTPMY"
     PFAM_domain     4091..4759
                     /aSDomain="APH"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF01636.25"
                     /description="Phosphotransferase enzyme family"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_3012_0137"
                     /evalue="4.50E-43"
                     /label="ctg1_3012"
                     /locus_tag="ctg1_3012"
                     /protein_end="254"
                     /protein_start="31"
                     /score="147.9"
                     /tool="antismash"
                     /translation="TPLNSYENRVYQFQDEDRKRYVVKFYRPERWSAEQIREEHEFALD
                     LQRDDVPVAAPLAFNNETLLTHQDFFFAVFPSVGGRQFEADNLDQMEWVGRYLGRMHQT
                     GSKKHFTSRPEIGVQEYLIEPRQLFETSTLIPSGFKDEFLRAADKLIDAVMAQWHNRFN
                     LLRLHGDCHAGNILWRDGPMFVDLDDARNGPAIQDLWMLLHGDKAEQRMQLEMIVEAYE
                     E"
     CDS             5001..5624
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: TIGR03651"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg1_3013"
                     /sec_met_domain="TIGR03651 (E-value: 5.9e-05, bitscore:
                     21.4, seeds: 9, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKKIWLALAGMILAFSASAAQPTDGKQFITLDKPVAGEPQVLEFF
                     SFYCPHCYDFEQVWHIADAVKKKLPEGTKMTKYHVEFLGPLGKEMTQAWAVAMALGVED
                     KITSPLFEAVQKTQTVQSVADIRDVFISAGVKGEEYDAAWNSFVVKSLVAQQEKAAADL
                     QLQGVPAMFVNGKYQVNQQGMDGSSLDAFVQDYANTVKYLVEKK"
     PFAM_domain     5118..5588
                     /aSDomain="DSBA"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF01323.22"
                     /description="DSBA-like thioredoxin domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_3013_0138"
                     /evalue="3.00E-27"
                     /label="ctg1_3013"
                     /locus_tag="ctg1_3013"
                     /protein_end="196"
                     /protein_start="39"
                     /score="95.8"
                     /tool="antismash"
                     /translation="QVLEFFSFYCPHCYDFEQVWHIADAVKKKLPEGTKMTKYHVEFLG
                     PLGKEMTQAWAVAMALGVEDKITSPLFEAVQKTQTVQSVADIRDVFISAGVKGEEYDAA
                     WNSFVVKSLVAQQEKAAADLQLQGVPAMFVNGKYQVNQQGMDGSSLDAFVQDY"
     CDS             complement(5637..6545)
                     /locus_tag="ctg1_3014"
                     /transl_table=11
                     /translation="MSRFLAVATLILSVLLTILVTIFCSVPIIIAGMLKLLIPLPAVWR
                     AISTFCNFMMYCWCEGLSLLLHLNPYLKWDVEGLEGLDKKNWYLLICNHHSWADIVVLC
                     VLFRKHIPMNKYFLKQQLAWVPFIGLACWALDMPFMRRYSRSYLLRHPERRGKDVETTR
                     RSCEKFRFHPTTIVNFVEGSRFTEEKRQQTRSSFKNLLSPKAAGVAMALNVLGKQFDKL
                     LDVTLCYPENDRTPFFDMLSGKLTRIVVRVNLLPVDEALHGDYVNDKNFKRSFQQWLNK
                     LWLGKDELIDTIKAEYKNAGQ"
     PFAM_domain     complement(5862..6323)
                     /aSDomain="Acyltransferase"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF01553.23"
                     /description="Acyltransferase"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_3014_0139"
                     /evalue="1.60E-12"
                     /label="ctg1_3014"
                     /locus_tag="ctg1_3014"
                     /protein_end="228"
                     /protein_start="74"
                     /score="47.3"
                     /tool="antismash"
                     /translation="DVEGLEGLDKKNWYLLICNHHSWADIVVLCVLFRKHIPMNKYFLK
                     QQLAWVPFIGLACWALDMPFMRRYSRSYLLRHPERRGKDVETTRRSCEKFRFHPTTIVN
                     FVEGSRFTEEKRQQTRSSFKNLLSPKAAGVAMALNVLGKQFDKLLDVTLC"
     CDS             6968..9754
                     /locus_tag="ctg1_3015"
                     /transl_table=11
                     /translation="MVQIPENPLILVDGSSYLYRAYHAFPPLTNSAGEPTGAMYGVLNM
                     LRSLILQYQPTHAAVVFDAKGKTFRDELFEHYKSHRPPMPDDLRAQIEPLHTMVKAMGL
                     PLLAVSGVEADDVIGTLAREAEKAGRPVLISTGDKDMAQLVTPHITLINTMTNTILGPD
                     EVVTKYGVPPELIIDFLALMGDSSDNIPGVPGVGEKTAQALLQGLGGLDTLYAESDKIA
                     GLTFRGAKTMAAKLEQNKEVAYLSYQLATIKTDVELELTCEQLEVQQPAAQTLLELFKK
                     YEFKRWSADVEAGKWLQAKGSKPAVKPQETIEIEAEADIPAAALSAENYVTILDEETLQ
                     TWIGKLKSAPLFAFDTETDSLDNISANLVGLSFATEPGIAAYVPVAHDYLDAPDQIPRE
                     RVLELLKPLLEDENARKVGQNLKYDRGVLENYGIELRGIAFDTMLESYTLDSVAGRHDM
                     DSLSERWLKHKTITFEEIAGKGKNQLTFNQIDLEQAGRYAAEDADVTLQLHLKMWPELQ
                     NNAGPLNVFQNIEMPLVPVISRIERNGVNIDPAVLHKHSEELTLRLAELEKKAHEIAGE
                     PFNLSSTKQLQTILFEKQGIKPLKKTPGGAPSTSEEVLEELALDYPLPKVILEHRGLAK
                     LKSTYTDKLPLMINPKTGRVHTSYHQAVTATGRLSSTDPNLQNIPVRNEEGRRIRQAFI
                     APKDYVIVSADYSQIELRIMAHLSRDKGLLSAFAEGKDIHRATAAEVFGLPLESVSNEQ
                     RRSAKAINFGLIYGMSAFGLSRQLNIPRKESQKYMDLYFERYPGVLEYMERTRAQAKDR
                     GYVETLDGRRLYLPDIKSSNGARRAGAERAAINAPMQGTAADIIKRAMIAVDSWLQSEK
                     PRVRLIMQVHDELVFEVHKDDVEAVSKKIHELMESSTKLDVPLLVEVGSGQNWDQAH"
     PFAM_domain     6992..7477
                     /aSDomain="5_3_exonuc_N"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF02739.18"
                     /description="5'-3' exonuclease, N-terminal resolvase-like
                     domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_3015_0140"
                     /evalue="3.70E-55"
                     /label="ctg1_3015"
                     /locus_tag="ctg1_3015"
                     /protein_end="170"
                     /protein_start="8"
                     /score="186.2"
                     /tool="antismash"
                     /translation="LILVDGSSYLYRAYHAFPPLTNSAGEPTGAMYGVLNMLRSLILQY
                     QPTHAAVVFDAKGKTFRDELFEHYKSHRPPMPDDLRAQIEPLHTMVKAMGLPLLAVSGV
                     EADDVIGTLAREAEKAGRPVLISTGDKDMAQLVTPHITLINTMTNTILGPDEVVTKYG"
     aSDomain        6992..9751
                     /aSDomain="TIGR00593"
                     /aSTool="tigrfam"
                     /description="pola: DNA polymerase I"
                     /detection="hmmscan"
                     /domain_id="TIGRFam_ctg1_3015_0036"
                     /evalue="1.20E-286"
                     /identifier="TIGR00593"
                     /label="ctg1_3015"
                     /locus_tag="ctg1_3015"
                     /protein_end="928"
                     /protein_start="8"
                     /score="951.6"
                     /tool="antismash"
                     /translation="LILVDGSSYLYRAYHAFPPLTNSAGEPTGAMYGVLNMLRSLILQY
                     QPTHAAVVFDAKGKTFRDELFEHYKSHRPPMPDDLRAQIEPLHTMVKAMGLPLLAVSGV
                     EADDVIGTLAREAEKAGRPVLISTGDKDMAQLVTPHITLINTMTNTILGPDEVVTKYGV
                     PPELIIDFLALMGDSSDNIPGVPGVGEKTAQALLQGLGGLDTLYAESDKIAGLTFRGAK
                     TMAAKLEQNKEVAYLSYQLATIKTDVELELTCEQLEVQQPAAQTLLELFKKYEFKRWSA
                     DVEAGKWLQAKGSKPAVKPQETIEIEAEADIPAAALSAENYVTILDEETLQTWIGKLKS
                     APLFAFDTETDSLDNISANLVGLSFATEPGIAAYVPVAHDYLDAPDQIPRERVLELLKP
                     LLEDENARKVGQNLKYDRGVLENYGIELRGIAFDTMLESYTLDSVAGRHDMDSLSERWL
                     KHKTITFEEIAGKGKNQLTFNQIDLEQAGRYAAEDADVTLQLHLKMWPELQNNAGPLNV
                     FQNIEMPLVPVISRIERNGVNIDPAVLHKHSEELTLRLAELEKKAHEIAGEPFNLSSTK
                     QLQTILFEKQGIKPLKKTPGGAPSTSEEVLEELALDYPLPKVILEHRGLAKLKSTYTDK
                     LPLMINPKTGRVHTSYHQAVTATGRLSSTDPNLQNIPVRNEEGRRIRQAFIAPKDYVIV
                     SADYSQIELRIMAHLSRDKGLLSAFAEGKDIHRATAAEVFGLPLESVSNEQRRSAKAIN
                     FGLIYGMSAFGLSRQLNIPRKESQKYMDLYFERYPGVLEYMERTRAQAKDRGYVETLDG
                     RRLYLPDIKSSNGARRAGAERAAINAPMQGTAADIIKRAMIAVDSWLQSEKPRVRLIMQ
                     VHDELVFEVHKDDVEAVSKKIHELMESSTKLDVPLLVEVGSGQNWDQAH"
     PFAM_domain     7478..7780
                     /aSDomain="5_3_exonuc"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF01367.22"
                     /description="5'-3' exonuclease, C-terminal SAM fold"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_3015_0141"
                     /evalue="4.70E-31"
                     /label="ctg1_3015"
                     /locus_tag="ctg1_3015"
                     /protein_end="271"
                     /protein_start="170"
                     /score="107.4"
                     /tool="antismash"
                     /translation="VPPELIIDFLALMGDSSDNIPGVPGVGEKTAQALLQGLGGLDTLY
                     AESDKIAGLTFRGAKTMAAKLEQNKEVAYLSYQLATIKTDVELELTCEQLEVQQPA"
     PFAM_domain     7955..8518
                     /aSDomain="DNA_pol_A_exo1"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF01612.22"
                     /description="3'-5' exonuclease"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_3015_0142"
                     /evalue="1.00E-41"
                     /label="ctg1_3015"
                     /locus_tag="ctg1_3015"
                     /protein_end="517"
                     /protein_start="329"
                     /score="142.7"
                     /tool="antismash"
                     /translation="YVTILDEETLQTWIGKLKSAPLFAFDTETDSLDNISANLVGLSFA
                     TEPGIAAYVPVAHDYLDAPDQIPRERVLELLKPLLEDENARKVGQNLKYDRGVLENYGI
                     ELRGIAFDTMLESYTLDSVAGRHDMDSLSERWLKHKTITFEEIAGKGKNQLTFNQIDLE
                     QAGRYAAEDADVTLQLHLKMWPELQ"
     PFAM_domain     8621..9742
                     /aSDomain="DNA_pol_A"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00476.22"
                     /description="DNA polymerase family A"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_3015_0143"
                     /evalue="2.30E-157"
                     /label="ctg1_3015"
                     /locus_tag="ctg1_3015"
                     /protein_end="925"
                     /protein_start="551"
                     /score="524.0"
                     /tool="antismash"
                     /translation="LHKHSEELTLRLAELEKKAHEIAGEPFNLSSTKQLQTILFEKQGI
                     KPLKKTPGGAPSTSEEVLEELALDYPLPKVILEHRGLAKLKSTYTDKLPLMINPKTGRV
                     HTSYHQAVTATGRLSSTDPNLQNIPVRNEEGRRIRQAFIAPKDYVIVSADYSQIELRIM
                     AHLSRDKGLLSAFAEGKDIHRATAAEVFGLPLESVSNEQRRSAKAINFGLIYGMSAFGL
                     SRQLNIPRKESQKYMDLYFERYPGVLEYMERTRAQAKDRGYVETLDGRRLYLPDIKSSN
                     GARRAGAERAAINAPMQGTAADIIKRAMIAVDSWLQSEKPRVRLIMQVHDELVFEVHKD
                     DVEAVSKKIHELMESSTKLDVPLLVEVGSGQNWD"
ORIGIN
        1 gctgggggtg aaaggccaat caaaccggga gatagctggt tctccccgaa agctatttag
       61 gtagcgcctc gtgaattcat ctccgggggt agagcactgt ttcggctagg gggccatccc
      121 ggcttaccaa cccgatgcaa actacgaata ccggagaatg ttatcacggg agacacacgg
      181 cgggtgctaa cgtccgtcgt gaagagggaa acaacccaga ccgccagcta aggtcccaaa
      241 gtcatggtta agtgggaaac gatgtgggaa ggcccagaca gccaggatgt tggcttagaa
      301 gcagccatca tttaaagaaa gcgtaatagc tcactggtcg agtcggcctg cgcggaagat
      361 gtaacggggc taaaccatgc accgaagctg cggcagcgac actgtgtgtt gttgggtagg
      421 ggagcgttct gtaagcctgc gaaggtggcc tgtgagggtt gctggaggta tcagaagtgc
      481 gaatgctgac ataagtaacg ataaagcggg tgaaaagccc gctcgccgga agaccaaggg
      541 ttcctgtcca acgttaatcg gggcagggtg agtcgacccc taaggcgagg ccgaaaggcg
      601 tagtcgatgg gaaacaggtt aatattcctg tacttggtgt tactgcgaag gggggacgga
      661 gaaggctatg ttagccgggc gacggttgtc ccggtttaag cgtgaaggtg tgtgctccag
      721 gcaaatccgg agtgctttaa cactgaggcg tgatgacgag gcactacggt gctgaagtaa
      781 caaatgccct gcttccagga aaagcctcta agcatcaggt aacacgaaat cgtaccccaa
      841 accgacacag gtggtcaggt agagaatacc aaggcgcttg agagaactcg ggtgaaggaa
      901 ctaggcaaaa tggtgccgta acttcgggag aaggcacgct gatatgtagg tgaagcgact
      961 tgctcgtgga gctgaaatca gtcgaagata ccagctggct gcaactgttt attaaaaaca
     1021 cagcactgtg caaacacgaa agtggacgta tacggtgtga cgcctgcccg gtgccggaag
     1081 gttaattgat ggggtcatcc gtaaggagaa gctcttgatc gaagccccgg taaacggcgg
     1141 ccgtaactat aacggtccta aggtagcgaa attccttgtc gggtaagttc cgacctgcac
     1201 gaatggcgta atgatggcca ggctgtctcc acccgagact cagtgaaatt gaactcgctg
     1261 tgaagatgca gtgtacccgc ggcaagacgg aaagaccccg tgaaccttta ctatagcttg
     1321 acactgaaca ctggtccttg atgtgtagga taggtgggag gctttgaagc gtggacgcca
     1381 gtctgcgtgg agccatcctt gaaataccac cctttaatgg ctggtgttct aacgtggacc
     1441 cgtaatccgg gttgcggaca gtgtctggtg ggtagtttga ctggggcggt ctcctcctaa
     1501 agcgtaacgg aggagcacga aggtcagcta atcctggtcg gacatcagga ggttagtgca
     1561 atggcataag ctggcttgac tgcgagcgtg acggcgcgag caggtgcgaa agcaggtcat
     1621 agtgatccgg tggttctgaa tggaagggcc atcgctcaac ggataaaagg tactccgggg
     1681 ataacaggct gataccgccc aagagttcat atcgacggcg gtgtttggca cctcgatgtc
     1741 ggctcatcac atcctggggc tgaagtaggt cccaagggta tggctgttcg ccatttaaag
     1801 tggtacgcga gctgggttta gaacgtcgtg agacagttcg gtccctatct gccgtgggcg
     1861 ctggagaatt gaggggggct gctcctagta cgagaggacc ggagtggacg catcactggt
     1921 gttcgggttg tcatgccaat ggcactgccc ggtagctaaa tgcggaagag ataagtgctg
     1981 aaagcatcta agcacgaaac ttgccccgag atgagttctc cctgagactt taagtctcct
     2041 gaaggaacgt tgaagacgac gacgttgata ggccgggtgt gtaagcgcag cgatgcgttg
     2101 agctaaccgg tactaatgaa ccgtgaggct taaccttaca acgccgaaga tgttttggcg
     2161 gtgagagaca tgaaatcagc ttgatgacag attaagtcga cagacctgag ggtgtgttga
     2221 taacagaatt tgcctggcgg cactagcgcg gtggtcccac ctgaccccat gccgaactca
     2281 gaagtgaaac gccgtagcgc cgatggtagt gtggggtctc cccatgcgag agtagggaac
     2341 tgccaggcat caaaccagtg aagaggccat cctgacggat ggcctttttg cgtttttatg
     2401 cagtgaaatt catgcctgcg atgctggttt tttgttttat gttccaggcc agcacgcttc
     2461 atgttaaaca ggcagtaagt accagcaaat taatccactt gcctaatcca gcgcataata
     2521 aacgtgacta tctgctcaat atcattcagg tttagtaccg gcacaccatg cattagaggg
     2581 atatcactgg caatggcgat aacatgctcg tccagcacca gctccgctaa atcatgacca
     2641 cagtcatgcc gccagagcag gattttgggc acaggctcgt gtttaaaacc ctcgataagt
     2701 accagatcca gttttgttgc atccattctg ctaatcagat atgccaaatc caactcggcc
     2761 tcatccggcg tttctgtcat taatgcccag cgttgcgaac tggcaaccaa tgtttgcgcc
     2821 gcacctgctt tacgtaattc gtagctgtct ttaccaggct tatcaacatc catatcgtga
     2881 tgggtatgtt tgattaaccc agggcgaata ccttgttcac agagagctgg aatcaacttc
     2941 ttaagcagcg tcgttttccc tgttccgctc caggcggcaa tggcaagtaa tgggatcata
     3001 ttctctcctg ccagtgcgcg agatcatctg gggtgttcac attggcgaag gcggatttca
     3061 catcactaaa atccaccgca tgccctcctg ctcgtcgcat aaataccatc acccgacgtt
     3121 cgccgctggt gagatagtcc tgcaaaaatg gtaaaacgct gcgatgtacc agagcaattg
     3181 ccgggtgatc tctctcgcca tcattaaccc acattgctgg cgcattatgc tgccggttct
     3241 tttgtaaccg cgtcataaga tccgttggta tacgtggcgt atcgcacggg caaaacagaa
     3301 accactcctc attactttgc tgcataacgg agagaattcc cgccagcggg ccaggaaaat
     3361 catccagcgt atctgtgagg acgggtaagc cactggtgcg ataaatttca aggtttcgat
     3421 tggcgctaat aactaagctg gttacctgtg gtgccagccg ttcggcaaca tgttgccaca
     3481 gcggtttgcc atttaattcc tgcagccctt tatcttttcc acccatccgc gaggcttttc
     3541 ctcccgccag taccacacct gttactgcac tactgtctgt cacccttatc gcctctttta
     3601 ttgtgggttt taccctgcta acgtgtctgt acccagagta aggagcacga ttatgaaatg
     3661 taaacgcctg aatgaagtta tcgaacttct ccagcctgca tggcaaaaag agccagagct
     3721 taatttagtg caatttttgc agaaactggc gcaagagtca ggttatcaag gcgaccttgt
     3781 ggatttaagt gatgacatcc tgatctatca tctgaaaatg cgcgactcct cgaaagatgc
     3841 ggtgatccca ggcattcaga aagattatga agaggatttt aaaaccgcgc tgttgcgcgc
     3901 gcgtggcgta attaaagagt aaaagcttgt aagcggcgca accgaatacg ctacgaaatg
     3961 atatcctgaa ttattcgtcg tattttcgga tcccaggatg acctgcaacg cctttacctt
     4021 ccagacatta cacccggata ccattatgga tgcgctgttt gagcagggga tccgggtgga
     4081 ttccgggctt accccgctca acagctatga aaaccgcgtt tatcaatttc aggatgaaga
     4141 tcgcaaacgt tatgtggtga agttttaccg tccggagcgt tggtctgcag aacaaatccg
     4201 tgaagagcat gaatttgctt tagatttgca gcgtgatgac gtgccagtcg cggcgccgct
     4261 cgctttcaac aatgaaacct tactcaccca tcaggacttc tttttcgccg tttttccaag
     4321 cgttggtggc cgtcagtttg aagccgacaa cctggatcaa atggagtggg taggtcgcta
     4381 ccttggccgt atgcatcaaa ccggcagtaa gaagcatttt acaagccgtc cggaaatcgg
     4441 cgttcaagaa tatctgattg agccacgcca actctttgaa acatcaacgc tcattccttc
     4501 tggttttaag gatgaatttt tgcgcgcagc cgataagctt atcgatgctg taatggcgca
     4561 atggcataac cgttttaatc ttttgcgtct gcatggtgat tgccatgcag ggaatattct
     4621 ctggcgagac gggccaatgt ttgttgattt agacgatgcc cgtaacggtc ctgccataca
     4681 ggatctgtgg atgttgctac acggtgataa agccgagcag cgtatgcagc tggagatgat
     4741 cgtcgaggcc tacgaagaat tcagtgaatt caacgtggct gagttggcgt taatcgagcc
     4801 gctacgcgcc atgcgtctgg tttactatct agcatggctg attcgtcgct gggacgatcc
     4861 ggcatttccc aaaaattttc cgtggctaag cagtgaagat cactggcaca gacagacatt
     4921 gatttttctt gaacaggtga aagttcttca agaaccacct ttagcattaa caccaatgta
     4981 ttaaatggag agagttaacc atgaagaaga tttggctggc gctggcagga atgattctgg
     5041 cttttagcgc ctcagcagca caaccgacag acggtaagca attcattaca cttgataagc
     5101 cagtagcggg cgagccgcag gtgcttgagt tcttctcgtt ttattgccca cactgctacg
     5161 acttcgagca agtttggcat attgctgacg cggtgaagaa gaagctgcca gagggcacaa
     5221 aaatgaccaa ataccacgtg gaattcttag gtccactggg taaagagatg acgcaggcgt
     5281 gggctgtagc catggcactt ggtgtggaag ataaaatcac ctctccgctg tttgaagcgg
     5341 tgcagaaaac gcaaaccgtg cagtctgttg ctgatattcg cgatgtcttc atcagcgcgg
     5401 gtgtgaaagg cgaagagtat gatgctgcat ggaacagctt cgtggtgaaa tcgctggttg
     5461 ctcagcaaga aaaagcggca gcggatttac aacttcaggg cgttccggcc atgtttgtta
     5521 acgggaaata tcaggttaac cagcagggca tggacggcag cagcctggat gccttcgttc
     5581 aggactacgc aaacaccgtg aaatatctgg ttgagaagaa ataaaaataa cgccggtcac
     5641 tgaccggcgt ttttgtattc tgctttgatg gtatcaatca gttcgtcttt cccaagccac
     5701 agtttattca gccactgctg gaaactccgt ttaaaattct tatcgttaac gtagtctcca
     5761 tgtaacgctt catccaccgg caataaattg actcgcacga caatacgcgt cagcttaccg
     5821 ctgagcatat caaagaatgg cgtccggtcg ttttccgggt aacagagcgt aacatcaagc
     5881 aatttatcga actgtttacc caatacattc agcgccatgg caacacctgc tgcttttggc
     5941 gacagcaggt ttttgaaaga agagcgtgtc tgctggcgct tttcttccgt aaagcgtgag
     6001 ccctcaacaa agttcacaat ggtggttggg tgaaagcgaa atttctcgca tgaacggcgc
     6061 gtggtttcga catctttacc ccgacgctca gggtggcgaa gcaaataact tctggagtaa
     6121 cggcgcataa aaggcatatc cagcgcccag caagcaagac caataaaagg tacccacgcc
     6181 agttgctgtt taaggaaata tttgttcatg ggaatatgtt tacgaaacaa aacgcataac
     6241 accacaatat ccgcccagct atgatgattg cagatcagca aataccagtt tttcttatcc
     6301 agcccttcca gcccctcaac atcccatttt aaataagggt tgagatgcaa tagtaatgaa
     6361 agcccttcgc accagcaata catcataaaa ttgcaaaacg ttgagatcgc gcgccatacc
     6421 gcaggaaggg gaattaacag cttgagcatt ccggcgataa taatgggcac ggagcaaaaa
     6481 atggtaacca atatggttag caggacactc aaaattagag tggctaccgc aaggaatctc
     6541 gacatagtta tattattcag aaagttagct gctaaaagca cactaaaaca agcgcaaggc
     6601 gcagatctta acagaaaaca gttatcagga atgcttaaac cttgctggta atacctgagc
     6661 aattattggc aataaatcaa atcaaaatta cttatatcca cacagcgtaa attgccagca
     6721 aatagcaata atgatcagct tttatagtat aactaattga atataaataa tttgtataat
     6781 cctacgatcg gcgaaatggc acaaaagtcc agcctgacaa aaactattca caaacttatc
     6841 cacaggatgt ttatgcgagc gatcccgacg atcgcgaaat cttttcggca ttttccgcga
     6901 aaaactcatg ttttctccct gtctgtggca tcctttaacc ataatttgat aaacaggcat
     6961 ggacatcatg gttcagatcc cagaaaaccc acttatcctt gttgacggct cgtcttacct
     7021 ttatcgcgcg tatcatgcgt ttccgccgct gaccaatagc gccggtgagc ctactggcgc
     7081 tatgtacggc gtgctcaaca tgttgcgcag cctgattttg caataccagc cgacacacgc
     7141 tgcggtggtg tttgatgcga aaggcaaaac cttccgtgat gaactgtttg agcattacaa
     7201 atctcatcgc ccgccaatgc cggacgattt gcgtgcgcaa attgagccgc tgcacaccat
     7261 ggtaaaagcg atgggactgc cgttactggc ggtctccggc gttgaagcgg atgatgtcat
     7321 cggcacgctg gcgcgtgaag ccgaaaaagc gggtcgaccc gtgttgataa gcactggcga
     7381 taaagatatg gcgcaactgg tgacgccgca tattacgctt atcaacacta tgaccaacac
     7441 gattcttggc ccggatgaag tcgtcacaaa atatggcgtc ccgccggagt taattatcga
     7501 tttcctcgcc ctgatggggg actcctcaga taacattcct ggggtgccgg gcgttggcga
     7561 gaaaacggcg caggcgctgc tacaagggct aggtggcctg gatacgctct atgccgaatc
     7621 ggataaaatc gccgggctca ccttccgcgg tgccaaaacc atggcggcaa aactagagca
     7681 gaataaagag gtggcctacc tctcttacca gctggccacg attaaaacag atgtcgaact
     7741 ggaactgacc tgcgaacaac tggaagttca gcagcctgcg gcgcagacgc tccttgagct
     7801 gtttaagaaa tatgaattca aacgctggag cgcagatgta gaagcgggca agtggctcca
     7861 ggcgaaaggc agtaaaccgg cggtgaaacc gcaggaaact attgagattg aggcagaagc
     7921 ggatattccc gcagctgcgc tgtcggcgga aaattacgtc accattctcg atgaagagac
     7981 gttgcaaaca tggatcggca aactgaaaag cgcaccgctc tttgctttcg atactgaaac
     8041 cgacagcctc gataatatca gcgccaatct ggttggcctc tcctttgcga ccgaaccggg
     8101 tatcgcggct tatgtgccag ttgcgcatga ttatcttgat gcgccggatc aaatcccgcg
     8161 tgagcgcgta ctggaattac tgaaaccgct gctggaagat gaaaatgccc gtaaagtggg
     8221 gcagaacctc aaatatgatc gcggtgtgct ggaaaattac ggcattgaac tacgcggcat
     8281 tgccttcgat accatgctgg aatcctacac gctggatagc gtcgctggcc gtcatgatat
     8341 ggacagcctc tccgagcgct ggctgaagca caaaaccatt acttttgaag agattgccgg
     8401 caaaggtaaa aaccaactga cgtttaatca gattgatctc gagcaggccg ggcgttatgc
     8461 ggcggaagat gccgatgtca cactgcaact gcatttgaag atgtggccgg agctgcaaaa
     8521 taatgccggg ccgctgaacg tcttccagaa cattgaaatg ccgctggtgc cggtaatttc
     8581 gcgtatcgag cgtaacggcg tcaatatcga tcccgccgtg ttacacaagc actccgaaga
     8641 gttgacgctg cgcctggcag agctggagaa aaaggcgcat gaaattgcgg gtgagccgtt
     8701 taatctctcg tcaaccaagc agctgcaaac cattctcttt gagaagcagg gcattaagcc
     8761 gttaaagaaa acgcctggcg gtgcgccgtc gacgtcggaa gaggtgctcg aagagctagc
     8821 gctggattac ccgctgccaa aagttattct cgaacatcgt gggctggcga agctgaaatc
     8881 gacctacacc gataagctgc cgctgatgat taacccgaaa accgggcgtg tgcatacctc
     8941 gtatcatcag gctgtgacgg caacgggccg tttatcttcg accgatccga acctgcaaaa
     9001 tattccggtg cgtaatgagg aaggccgccg tatccgccag gcctttatcg cgccgaaaga
     9061 ttacgtcatt gtctcggcgg actactcgca aattgagctg cgtattatgg cgcacctgtc
     9121 acgcgacaaa ggtctgctat ctgcatttgc agaaggtaaa gacattcacc gcgcaacggc
     9181 ggcagaagtg tttggtttgc cactggaaag cgtcagtaac gagcagcgcc gcagcgcgaa
     9241 agcgatcaac tttgggctga tttacggcat gagcgccttt ggcttatcgc gtcagctcaa
     9301 tatcccgcgt aaagagtcgc agaagtacat ggatctctac ttcgagcgtt accctggtgt
     9361 gctggaatat atggagcgca ctcgcgcaca ggctaaagat cgtggctatg ttgaaaccct
     9421 cgacgggcgt cgtctttacc tgccggacat caaatccagc aatggtgcca gacgagccgg
     9481 tgcggaacgt gcggcgatca atgccccaat gcaaggcacg gcagccgata tcattaaacg
     9541 cgccatgatt gctgtagata gctggttgca aagtgagaaa ccgcgcgtgc ggttgatcat
     9601 gcaggtgcac gatgaactgg tgtttgaagt gcacaaagat gatgttgagg ccgtatcgaa
     9661 aaagatccat gaactgatgg agagcagcac caaactggat gtaccgttgc tggtggaagt
     9721 cggaagtggt caaaactggg atcaagcgca ctaagtgttc ggtggataaa gggctttttc
     9781 tgtaagtaag caacaaatag ccgtcagttt tgtgacaatc attagaattc cctatgtaaa
     9841 aattgaaaag aaattacaaa aagtgctttg tccggatcta aaaagggagt agagttattc
     9901 gcgtagggta cagaggtaag atgttctatc tttcagacct tttacttcac gtaatcggat
     9961 ttggctgaat atttagccgc cccagtcaga aatgactggg gcgtttttta ttgtgcaaaa
    10021 taaataaaga aaaaagcgcg gcgaatgcca cgcttgatat gaaggttact cgcccgtttc
    10081 ttcttccact ggcggcaggt tattgaacca gccatccagt ttctcacgta acttgtccac
    10141 gccctgtttc ttcagcgacg agaaagtttc cacctgtatg tcgccgttaa aagcaagcac
    10201 ggcttcacgc accatattca gttgcgcttt ccgcgcgccg ctggccagtt tatccgcctt
    10261 ggtcagcagc accagcactt gcagattgct ctcgactgcc cacaggatca tctgctgatc
    10321 aagatctttc agcggatgac gaatatccat cagcactacc aaaccttgca ggcactggcg
    10381 tttttcgagg tattcaccca gcgcgcgttg ccatttgagt ttcatctctt ccggcacttc
    10441 cgcataaccg taacccggca agtcgacaag acgtttgcct tcagcgactt caaacaagtt
    10501 gatcagctgc gtacggccgg gcgttttcga ggtccgcgcc aggtttttct ggtgggtcag
    10561 ggtattaagt gcgctcgatt tacctgcgtt ggagcggcca gcaaaagcca cttcaatgcc
    10621 agta
//
