Select genomic region:
Overview
1.1
1.2
1.3

### Identified secondary metabolite regions using strictness 'relaxed'

NC_014319.1

Region | Type | From | To | Most similar known cluster | Similarity
--- | --- | --- | --- | --- | ---
Region 1 | furan | 46,659 | 67,597 | methylenomycin A | Other | 9%
Region 2 | T3PKS | 895,294 | 936,454 |
Region 3 | hglE-KS | 1,848,497 | 1,890,977 |

NC_014319.1 - Region 1 - furan
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 46,659 - 67,597 nt. (total: 20,939 nt) Show pHMM detection rules used
furan: (mmyO or AvrD)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
MIBiG comparison
KnownClusterBlast
Pfam domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | furan | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000487.1 |  | 0.17 | RiPP | carnocyclin | Carnobacterium maltaromaticum
BGC0001526.1 |  | 0.17 | Other | bartolosides E, bartolosides F, bartolosides G, bartolosides H, bartolosides I, bartolosides J, bartolosides K | Synechocystis salina LEGE 06099
BGC0001525.1 |  | 0.16 | Other | bartoloside 2, bartoloside 3, bartoloside 4 | Synechocystis salina LEGE 06155
BGC0000502.1 |  | 0.16 | RiPP | cerecidin, cerecidin A1, cerecidin A2, cerecidin A3, cerecidin A4, cerecidin A5, cerecidin A6, cerecidin A7 | Bacillus cereus
BGC0001407.1 |  | 0.16 | RiPP | bicereucin | Bacillus cereus SJ1
BGC0000554.1 |  | 0.16 | RiPP | SRO15-3108 | Streptomyces filamentosus NRRL 15998
BGC0001210.1 |  | 0.16 | RiPP | pseudomycoicidin | Bacillus pseudomycoides DSM 12442
BGC0000516.1 |  | 0.16 | RiPP | geobacillin II | Geobacillus thermodenitrificans
BGC0001660.1 |  | 0.16 | RiPP | mathermycin | Marinactinospora thermotolerans
BGC0001579.1 |  | 0.16 | RiPP | duramycin | Streptomyces cinnamoneus

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000487.1 |  | 0.48 | RiPP | carnocyclin | Carnobacterium maltaromaticum
BGC0001526.1 |  | 0.48 | Other | bartolosides E, bartolosides F, bartolosides G, bartolosides H, bartolosides I, bartolosides J, bartolosides K | Synechocystis salina LEGE 06099
BGC0001525.1 |  | 0.47 | Other | bartoloside 2, bartoloside 3, bartoloside 4 | Synechocystis salina LEGE 06155
BGC0000502.1 |  | 0.47 | RiPP | cerecidin, cerecidin A1, cerecidin A2, cerecidin A3, cerecidin A4, cerecidin A5, cerecidin A6, cerecidin A7 | Bacillus cereus
BGC0001407.1 |  | 0.47 | RiPP | bicereucin | Bacillus cereus SJ1
BGC0000554.1 |  | 0.47 | RiPP | SRO15-3108 | Streptomyces filamentosus NRRL 15998
BGC0001210.1 |  | 0.47 | RiPP | pseudomycoicidin | Bacillus pseudomycoides DSM 12442
BGC0000516.1 |  | 0.46 | RiPP | geobacillin II | Geobacillus thermodenitrificans
BGC0001660.1 |  | 0.46 | RiPP | mathermycin | Marinactinospora thermotolerans
BGC0001579.1 |  | 0.46 | RiPP | duramycin | Streptomyces cinnamoneus

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.
Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
NC_014319.1 - Region 2 - T3PKS
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 895,294 - 936,454 nt. (total: 41,161 nt) Show pHMM detection rules used
T3PKS: (Chal_sti_synt_C or Chal_sti_synt_N)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
NRPS/PKS domains
MIBiG comparison
KnownClusterBlast
Pfam domains
TIGRFAM domains
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
A glossary is available here.
Selected features only
Show module domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | T3PKS | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000286.1 |  | 0.22 | Polyketide | viguiepinol | Streptomyces sp. KO-3988
BGC0000255.1 |  | 0.20 | Polyketide | pederin | Uncultured bacterium
BGC0001120.1 |  | 0.16 | NRP, Polyketide | burkholderic acid | Burkholderia thailandensis E264
BGC0000720.1 |  | 0.16 | Saccharide | tobramycin | Streptoalloteichus tenebrarius
BGC0001104.1 |  | 0.16 | NRP, Polyketide | myxovirescin A1 | Myxococcus xanthus DK 1622
BGC0000719.1 |  | 0.16 | Saccharide | tobramycin | Streptoalloteichus hindustanus
BGC0000880.1 |  | 0.15 | Other (Nucleoside) | tunicamycin B1 | Streptomyces chartreusis NRRL 3882
BGC0000874.1 |  | 0.15 | Other | blasticidin S | Streptomyces griseochromogenes
BGC0001591.1 |  | 0.14 | Other | fatty acid enol ester | uncultured bacterium CSLC2
BGC0001688.1 |  | 0.14 | Other | N-tetradecanoyl tyrosine | uncultured bacterium CSLC2

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000286.1 |  | 0.55 | Polyketide | viguiepinol | Streptomyces sp. KO-3988
BGC0000255.1 |  | 0.53 | Polyketide | pederin | Uncultured bacterium
BGC0001120.1 |  | 0.47 | NRP, Polyketide | burkholderic acid | Burkholderia thailandensis E264
BGC0000720.1 |  | 0.46 | Saccharide | tobramycin | Streptoalloteichus tenebrarius
BGC0001104.1 |  | 0.46 | NRP, Polyketide | myxovirescin A1 | Myxococcus xanthus DK 1622
BGC0000719.1 |  | 0.46 | Saccharide | tobramycin | Streptoalloteichus hindustanus
BGC0000880.1 |  | 0.46 | Other (Nucleoside) | tunicamycin B1 | Streptomyces chartreusis NRRL 3882
BGC0000874.1 |  | 0.44 | Other | blasticidin S | Streptomyces griseochromogenes
BGC0001591.1 |  | 0.44 | Other | fatty acid enol ester | uncultured bacterium CSLC2
BGC0001688.1 |  | 0.44 | Other | N-tetradecanoyl tyrosine | uncultured bacterium CSLC2

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.

No matches found.

Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
NC_014319.1 - Region 3 - hglE-KS
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 1,848,497 - 1,890,977 nt. (total: 42,481 nt) Show pHMM detection rules used
hglE-KS: (hglE or hglD)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
NRPS/PKS domains
MIBiG comparison
KnownClusterBlast
NRPS/PKS modules
Pfam domains
TIGRFAM domains
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
A glossary is available here.
Selected features only
Show module domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | hglE-KS | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000044.1 |  | 0.18 | Polyketide | dawenol | Stigmatella aurantiaca DW4/3-1
BGC0000410.1 |  | 0.17 | NRP | pseudomonine | Pseudomonas fluorescens
BGC0001579.1 |  | 0.17 | RiPP | duramycin | Streptomyces cinnamoneus
BGC0001364.1 |  | 0.17 | RiPP | cinnamycin B | Actinomadura atramentaria DSM 43919
BGC0001660.1 |  | 0.17 | RiPP | mathermycin | Marinactinospora thermotolerans
BGC0001258.1 |  | 0.17 | Polyketide | 1,3,6,8-tetrahydroxynaphthalene | Glarea lozoyensis
BGC0000626.1 |  | 0.17 | RiPP | thuricin | Bacillus thuringiensis
BGC0000616.1 |  | 0.17 | RiPP | amylocyclicin | Bacillus velezensis FZB42
BGC0000539.1 |  | 0.16 | RiPP | nukacin ISK-1 | Staphylococcus warneri
BGC0001779.1 |  | 0.16 | RiPP | siamycin | Streptomyces nodosus

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000044.1 |  | 0.49 | Polyketide | dawenol | Stigmatella aurantiaca DW4/3-1
BGC0000410.1 |  | 0.49 | NRP | pseudomonine | Pseudomonas fluorescens
BGC0001579.1 |  | 0.48 | RiPP | duramycin | Streptomyces cinnamoneus
BGC0001364.1 |  | 0.48 | RiPP | cinnamycin B | Actinomadura atramentaria DSM 43919
BGC0001660.1 |  | 0.48 | RiPP | mathermycin | Marinactinospora thermotolerans
BGC0001258.1 |  | 0.48 | Polyketide | 1,3,6,8-tetrahydroxynaphthalene | Glarea lozoyensis
BGC0000626.1 |  | 0.48 | RiPP | thuricin | Bacillus thuringiensis
BGC0000616.1 |  | 0.48 | RiPP | amylocyclicin | Bacillus velezensis FZB42
BGC0000539.1 |  | 0.47 | RiPP | nukacin ISK-1 | Staphylococcus warneri
BGC0001779.1 |  | 0.47 | RiPP | siamycin | Streptomyces nodosus

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.

No matches found.

Module view
Shows module structures for each candidate in NRPS- and PKS regions. Genes are shown in predicted order, and are only present when containing at least one complete module. A domain glossary is available here.
Legend
Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
NRPS/PKS products
NRPS/PKS monomers
Predicted core structure(s)
Shows estimated product structure and polymer for each candidate cluster in the region. To show the product, click on the expander or the candidate cluster feature drawn in the overview.
For candidate cluster 3, location 1848496 - 1890977:
Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:
  (mal)

Direct lookup in NORINE database: strict or relaxed
Link to NORINE database query form
NRPS/PKS monomer predictions
Shows the predicted monomers for each adynelation domain and acyltransferase within genes. Each gene prediction can be expanded to view detailed predictions of each domain. Each prediction can be expanded to view the predictions by tool (and, for some tools, further expanded for extra details).

ctg1_1829: mal
  PKS_AT (30..321): mal
  ATSignature: (unknown)
  No matches above 50%
  minowa: Malonyl-CoA
  Prediction, score:
    Malonyl-CoA: 27.5
    Methoxymalonyl-CoA: 21.9
    Methylmalonyl-CoA: 18.4
    trans-1,2-CPDA: 0.0
    inactive: 0.0
    fatty_acid: 0.0
    Propionyl-CoA: 0.0
    Isobutyryl-CoA: 0.0
    Ethylmalonyl-CoA: 0.0
    CHC-CoA: 0.0
    Benzoyl-CoA: 0.0
    Acetyl-CoA: 0.0
    3-Methylbutyryl-CoA: 0.0
    2-Methylbutyryl-CoA: 0.0