GCF_000621485.1_ASM62148v1_genomic - 6 region(s)

Identified secondary metabolite regions using strictness 'relaxed'

NZ_JHYF01000001 (original name was: NZ_JHYF01000001.1)

Region	Type	From	To	Most similar known cluster		Similarity
Region 1.1	ranthipeptide	52,073	73,696
Region 1.2	transAT-PKS,NRPS-like,NRPS	131,825	199,455	chondrochloren A	NRP + Polyketide:Modular type I	22%
Region 1.3	NRPS	227,319	302,594

NZ_JHYF01000002 (original name was: NZ_JHYF01000002.1)

Region	Type	From	To	Most similar known cluster		Similarity
Region 2.1	RiPP-like	13,872	24,708

NZ_JHYF01000003 (original name was: NZ_JHYF01000003.1)

Region	Type	From	To	Most similar known cluster		Similarity
Region 3.1	resorcinol	83,950	125,062	S-layer glycan	Saccharide	20%

NZ_JHYF01000017 (original name was: NZ_JHYF01000017.1)

Region	Type	From	To	Most similar known cluster		Similarity
Region 14.1	NRPS	17,740	88,588	zwittermicin A	NRP + Polyketide	7%

Region	Type	From	To	Most similar known cluster	Similarity
Region 1.1	ranthipeptide	52,073	73,696
Region 1.2	transAT-PKS,NRPS-like,NRPS	131,825	199,455	chondrochloren A	NRP + Polyketide:Modular type I	22%
Region 1.3	NRPS	227,319	302,594
Region 2.1	RiPP-like	13,872	24,708
Region 3.1	resorcinol	83,950	125,062	S-layer glycan	Saccharide	20%
Region 14.1	NRPS	17,740	88,588	zwittermicin A	NRP + Polyketide	7%

No secondary metabolite regions were found in these records:: NZ_KK211286.1; NZ_JHYF01000006 (original name was: NZ_JHYF01000006.1); NZ_KK211287.1; NZ_JHYF01000009 (original name was: NZ_JHYF01000009.1); NZ_KK211288.1; NZ_JHYF01000012 (original name was: NZ_JHYF01000012.1); NZ_JHYF01000013 (original name was: NZ_JHYF01000013.1); NZ_JHYF01000014 (original name was: NZ_JHYF01000014.1); NZ_JHYF01000015 (original name was: NZ_JHYF01000015.1); NZ_JHYF01000016 (original name was: NZ_JHYF01000016.1); NZ_JHYF01000018 (original name was: NZ_JHYF01000018.1); NZ_JHYF01000019 (original name was: NZ_JHYF01000019.1); NZ_JHYF01000020 (original name was: NZ_JHYF01000020.1); NZ_JHYF01000021 (original name was: NZ_JHYF01000021.1); NZ_JHYF01000022 (original name was: NZ_JHYF01000022.1); NZ_JHYF01000023 (original name was: NZ_JHYF01000023.1); NZ_JHYF01000024 (original name was: NZ_JHYF01000024.1); NZ_JHYF01000025 (original name was: NZ_JHYF01000025.1); NZ_JHYF01000026 (original name was: NZ_JHYF01000026.1); NZ_JHYF01000027 (original name was: NZ_JHYF01000027.1); NZ_JHYF01000028 (original name was: NZ_JHYF01000028.1); NZ_JHYF01000029 (original name was: NZ_JHYF01000029.1); NZ_JHYF01000030 (original name was: NZ_JHYF01000030.1); NZ_JHYF01000031 (original name was: NZ_JHYF01000031.1); NZ_JHYF01000032 (original name was: NZ_JHYF01000032.1); NZ_JHYF01000033 (original name was: NZ_JHYF01000033.1); NZ_JHYF01000034 (original name was: NZ_JHYF01000034.1); NZ_JHYF01000035 (original name was: NZ_JHYF01000035.1); NZ_JHYF01000036 (original name was: NZ_JHYF01000036.1); NZ_JHYF01000037 (original name was: NZ_JHYF01000037.1); NZ_JHYF01000038 (original name was: NZ_JHYF01000038.1); NZ_JHYF01000039 (original name was: NZ_JHYF01000039.1); NZ_JHYF01000040 (original name was: NZ_JHYF01000040.1); NZ_JHYF01000041 (original name was: NZ_JHYF01000041.1); NZ_JHYF01000042 (original name was: NZ_JHYF01000042.1); NZ_JHYF01000043 (original name was: NZ_JHYF01000043.1); NZ_JHYF01000044 (original name was: NZ_JHYF01000044.1); NZ_JHYF01000045 (original name was: NZ_JHYF01000045.1); NZ_JHYF01000046 (original name was: NZ_JHYF01000046.1); NZ_JHYF01000047 (original name was: NZ_JHYF01000047.1)

Compact view

c00001_NZ_JHYF.. - Region 1 - ranthipeptide

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Location: 52,073 - 73,696 nt. (total: 21,624 nt) Show pHMM detection rules used

ranthipeptide: (TIGR03973 or SCIFF or (cds(PF04055 and (TIGR04085 or SPASM)) and minimum(1, [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE, Cytolysin_C_RRE, Goadsporin_CD_RRE, Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE, Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE, Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE, Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE, Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE, Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE, Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE, Thiaglutamate_B_RRE, Thiaglutamate_G_RRE, Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE, Thurincin_rSAM_RRE, Trifolitoxin_RRE]) and not (TIGR01716 or subtilosin or TIGR02111 or TIGR03966 or TIGR04103 or YcaO or TIGR03882)))

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

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Gene details

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MIBiG comparison

KnownClusterBlast

Pfam domains

TIGRFAM domains

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001387.1	0.18	Other	nucleocidin	Streptomyces calvus
BGC0000695.1	0.09	Saccharide	fortimicin	Micromonospora olivasterospora
BGC0001935.1	0.07	Other	3,7-dihydroxytropolone	Streptomyces cyaneofuscatus
BGC0001487.1	0.07	Other	3,7-dihydroxytropolone	Streptomyces cyaneofuscatus
BGC0001943.1	0.04	NRP	vioprolides A, vioprolides B, vioprolides C, vioprolides D	Cystobacter sp.
BGC0001822.1	0.04	NRP	vioprolide A	Cystobacter sp.
BGC0001704.1	0.04	Other	nocuolin A	Nodularia sp. HBU26
BGC0001358.1	0.03	Polyketide	leucinostatin A, leucinostatin B	Purpureocillium lilacinum
BGC0001591.1	0.03	Other	fatty acid enol ester	uncultured bacterium CSLC2
BGC0001688.1	0.03	Other	N-tetradecanoyl tyrosine	uncultured bacterium CSLC2

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001387.1	0.49	Other	nucleocidin	Streptomyces calvus
BGC0000695.1	0.32	Saccharide	fortimicin	Micromonospora olivasterospora
BGC0001935.1	0.27	Other	3,7-dihydroxytropolone	Streptomyces cyaneofuscatus
BGC0001487.1	0.27	Other	3,7-dihydroxytropolone	Streptomyces cyaneofuscatus
BGC0001943.1	0.19	NRP	vioprolides A, vioprolides B, vioprolides C, vioprolides D	Cystobacter sp.
BGC0001822.1	0.19	NRP	vioprolide A	Cystobacter sp.
BGC0001704.1	0.18	Other	nocuolin A	Nodularia sp. HBU26
BGC0001358.1	0.17	Polyketide	leucinostatin A, leucinostatin B	Purpureocillium lilacinum
BGC0001591.1	0.16	Other	fatty acid enol ester	uncultured bacterium CSLC2
BGC0001688.1	0.16	Other	N-tetradecanoyl tyrosine	uncultured bacterium CSLC2

Similar known gene clusters

No matches found.

Detailed Pfam domain annotation

Selected features only

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Detailed TIGRFAM domain annotation

Selected features only

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c00001_NZ_JHYF.. - Region 2 - NRPS,NRPS-like,transAT-PKS

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Location: 131,825 - 199,455 nt. (total: 67,631 nt) Show pHMM detection rules used

transAT-PKS: (cds(PKS_AT and not (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS)) and (cds(ATd and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS)) or cds(tra_KS and PP-binding)))
NRPS-like: cds((PP-binding or NAD_binding_4) and (AMP-binding or A-OX))
NRPS: cds(Condensation and (AMP-binding or A-OX))

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

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Gene details

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NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

Pfam domains

TIGRFAM domains

Detailed domain annotation

Selected features only

Show module domains

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001909.1	0.95	Polyketide	strobilurin	Strobilurus tenacellus
BGC0001831.1	0.68	Polyketide	alkylpyrone-407, alkylpyrone-393	Myxococcus xanthus DK 1622
BGC0001264.1	0.59	Polyketide	betaenone A, betaenone B, betaenone C	Phoma betae
BGC0001280.1	0.59	Polyketide	betaenone C, betaenone A	Phoma betae
BGC0001524.1	0.59	NRP, Polyketide	barnesin A	Sulfurospirillum barnesii SES-3
BGC0001203.1	0.59	NRP, Polyketide	clarexpoxcin	uncultured bacterium AR_456
BGC0001897.1	0.59	Polyketide	cepacin A	Burkholderia ambifaria IOP40-10
BGC0001458.1	0.58	Other (Aminocoumarin)	salinipostin G	Salinispora tropica CNB-440
BGC0001161.1	0.58	Polyketide	1-heptadecene	Moorea bouillonii PNG
BGC0000999.1	0.58	NRP, Polyketide	heat-stable antifungal factor	Lysobacter enzymogenes

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001909.1	0.65	Polyketide	strobilurin	Strobilurus tenacellus
BGC0001796.1	0.63	NRP	tauramamide	Brevibacillus laterosporus DSM 25
BGC0001671.1	0.62	NRP	monobactam	Agrobacterium tumefaciens
BGC0001502.1	0.61	NRP	amonabactin P 750	Aeromonas hydrophila subsp. hydrophila ATCC 7966
BGC0000349.1	0.61	NRP	erythrochelin	Saccharopolyspora erythraea NRRL 2338
BGC0000297.1	0.60	NRP, Polyketide, Saccharide	aeruginoside 126B, aeruginoside 126A	Planktothrix agardhii NIVA-CYA 126
BGC0001479.1	0.60	NRP	anabaenopeptin NZ857, nostamide A	Nostoc punctiforme PCC 73102
BGC0000298.1	0.59	NRP	aeruginosin 98-A, aeruginosin 98-B, aeruginosin 98-C	Microcystis aeruginosa NIES-98
BGC0000426.1	0.58	NRP	sevadicin	Paenibacillus larvae
BGC0000335.1	0.58	NRP	cystomanamide A, cystomanamide B, cystomanamide C, cystomanamide D	Cystobacter fuscus

Similar known gene clusters

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Detailed Pfam domain annotation

Selected features only

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Detailed TIGRFAM domain annotation

Selected features only

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NRPS/PKS products

NRPS/PKS monomers

Predicted core structure(s)

For candidate cluster 2, location 131824 - 199455:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (D-ile - D-phe - lys)

Direct lookup in NORINE database: strict or relaxed

For candidate cluster 3, location 131824 - 177000:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (D-ile - D-phe - lys)

Direct lookup in NORINE database: strict or relaxed

For candidate cluster 4, location 142369 - 199455:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (D-ile - D-phe - lys)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS monomer predictions

ctg1_145

CAL_domain (33..475): pk

minowa: fatty_acid

Prediction, score:

fatty_acid: 218.5
NH2: 18.8
shikimic_acid: 0.0
Acetyl-CoA: 0.0
AHBA: 0.0

ctg1_146

PKS_AT (39..321): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 66.7%; inactive: 58.3%; 2-Rhyd-Malonyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 67.6
inactive: 35.1
Methoxymalonyl-CoA: 20.4
Methylmalonyl-CoA: 14.6
Propionyl-CoA: 10.5
trans-1,2-CPDA: 0.0
fatty_acid: 0.0
Isobutyryl-CoA: 0.0
Ethylmalonyl-CoA: 0.0
CHC-CoA: 0.0
Benzoyl-CoA: 0.0
Acetyl-CoA: 0.0
3-Methylbutyryl-CoA: 0.0
2-Methylbutyryl-CoA: 0.0

ctg1_152

Search NORINE for peptide: strict or relaxed

AMP-binding (1873..2268): ile

NRPSPredictor2: ile

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic
Large clusters prediction:: gly, ala, val, leu, ile, abu, iva
Small clusters prediction:: val, leu, ile, abu, iva
Single AA prediction:: ile

Stachelhaus prediction details:

Stachelhaus sequence:: DGFFLGVVYK
Nearest Stachelhaus code:: ile
Stachelhaus code match:: 100% (strong)

AMP-binding (3391..3780): phe

NRPSPredictor2: phe

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aromatic
Large clusters prediction:: phe, trp, phg, tyr, bht
Small clusters prediction:: phe, trp
Single AA prediction:: phe

Stachelhaus prediction details:

Stachelhaus sequence:: DAWTIAAICK
Nearest Stachelhaus code:: phe
Stachelhaus code match:: 100% (strong)

AMP-binding (4900..5290): lys

NRPSPredictor2: lys

SVM prediction details:

Predicted physicochemical class:: hydrophilic
Large clusters prediction:: orn, lys, arg
Small clusters prediction:: N/A
Single AA prediction:: lys

Stachelhaus prediction details:

Stachelhaus sequence:: DtESIGSVCK
Nearest Stachelhaus code:: lys
Stachelhaus code match:: 90% (moderate)

c00001_NZ_JHYF.. - Region 3 - NRPS

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Location: 227,319 - 302,594 nt. (total: 75,276 nt) Show pHMM detection rules used

NRPS: cds(Condensation and (AMP-binding or A-OX))

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

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Gene details

Select a gene to view the details available for it

NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

Pfam domains

TIGRFAM domains

Detailed domain annotation

Selected features only

Show module domains

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001050.1	0.39	NRP, Polyketide	thalassospiramide A	Tistrella bauzanensis
BGC0000427.1	0.35	NRP	shinorine, 4-deoxygadusol, mycosporine glycine	Trichormus variabilis ATCC 29413
BGC0001479.1	0.35	NRP	anabaenopeptin NZ857, nostamide A	Nostoc punctiforme PCC 73102
BGC0000426.1	0.34	NRP	sevadicin	Paenibacillus larvae
BGC0001615.1	0.33	NRP	hexose-palythine-serine, hexose-shinorine	Heteroscytonema crispum UCFS10
BGC0001135.1	0.33	NRP	bicornutin A1, bicornutin A2	Xenorhabdus budapestensis
BGC0001833.1	0.33	NRP	icosalide A, icosalide B	Burkholderia gladioli
BGC0001128.1	0.32	NRP	luminmide	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001132.1	0.32	NRP	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0000389.1	0.32	NRP	massetolide A	Pseudomonas fluorescens SS101

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001050.1	0.71	NRP, Polyketide	thalassospiramide A	Tistrella bauzanensis
BGC0000427.1	0.68	NRP	shinorine, 4-deoxygadusol, mycosporine glycine	Trichormus variabilis ATCC 29413
BGC0001479.1	0.68	NRP	anabaenopeptin NZ857, nostamide A	Nostoc punctiforme PCC 73102
BGC0000426.1	0.67	NRP	sevadicin	Paenibacillus larvae
BGC0001615.1	0.66	NRP	hexose-palythine-serine, hexose-shinorine	Heteroscytonema crispum UCFS10
BGC0001135.1	0.66	NRP	bicornutin A1, bicornutin A2	Xenorhabdus budapestensis
BGC0001833.1	0.66	NRP	icosalide A, icosalide B	Burkholderia gladioli
BGC0001128.1	0.66	NRP	luminmide	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001132.1	0.65	NRP	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0000389.1	0.65	NRP	massetolide A	Pseudomonas fluorescens SS101

Similar known gene clusters

No matches found.

Module view

Legend

Detailed Pfam domain annotation

Selected features only

Expand to show all names

Detailed TIGRFAM domain annotation

Selected features only

Expand to show all names

NRPS/PKS products

NRPS/PKS monomers

Predicted core structure(s)

For candidate cluster 5, location 227318 - 302594:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (his) + (mal) + (X - X) + (D-asn - leu - ile - X)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS monomer predictions

ctg1_221

Search NORINE for peptide: strict or relaxed

AMP-binding (465..858): his

NRPSPredictor2: his

SVM prediction details:

Predicted physicochemical class:: N/A
Large clusters prediction:: phe, trp, phg, tyr, bht
Small clusters prediction:: tyr, bht
Single AA prediction:: tyr

Stachelhaus prediction details:

Stachelhaus sequence:: DSELTAEVCK
Nearest Stachelhaus code:: his
Stachelhaus code match:: 100% (strong)

ctg1_223

Search NORINE for peptide: strict or relaxed

AMP-binding (276..685): X

NRPSPredictor2: (unknown)

SVM prediction details:

Predicted physicochemical class:: N/A
Large clusters prediction:: N/A
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: DVtaFGyIyK
Nearest Stachelhaus code:: glu
Stachelhaus code match:: 60% (weak)

AMP-binding (1327..1723): X

NRPSPredictor2: phe, trp, phg, tyr, bht

SVM prediction details:

Predicted physicochemical class:: N/A
Large clusters prediction:: phe, trp, phg, tyr, bht
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: DgfLVgIiCK
Nearest Stachelhaus code:: 4ppro
Stachelhaus code match:: 60% (weak)

ctg1_230

Search NORINE for peptide: strict or relaxed

AMP-binding (897..1291): asn

NRPSPredictor2: asn

SVM prediction details:

Predicted physicochemical class:: hydrophilic
Large clusters prediction:: asp, asn, glu, gln, aad
Small clusters prediction:: asp, asn
Single AA prediction:: asn

Stachelhaus prediction details:

Stachelhaus sequence:: DLTKIGEVGK
Nearest Stachelhaus code:: asn
Stachelhaus code match:: 100% (strong)

AMP-binding (2408..2790): leu

NRPSPredictor2: leu

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic
Large clusters prediction:: gly, ala, val, leu, ile, abu, iva
Small clusters prediction:: val, leu, ile, abu, iva
Single AA prediction:: leu

Stachelhaus prediction details:

Stachelhaus sequence:: DAWyLGNVVK
Nearest Stachelhaus code:: leu
Stachelhaus code match:: 90% (moderate)

AMP-binding (3434..3828): ile

NRPSPredictor2: ile

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic
Large clusters prediction:: gly, ala, val, leu, ile, abu, iva
Small clusters prediction:: val, leu, ile, abu, iva
Single AA prediction:: ile

Stachelhaus prediction details:

Stachelhaus sequence:: DGFFLGVVYK
Nearest Stachelhaus code:: ile
Stachelhaus code match:: 100% (strong)

AMP-binding (4473..4862): X

NRPSPredictor2: orn, lys, arg

SVM prediction details:

Predicted physicochemical class:: hydrophilic
Large clusters prediction:: orn, lys, arg
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: DVeqtGhVDK
Nearest Stachelhaus code:: orn
Stachelhaus code match:: 60% (weak)

c00002_NZ_JHYF.. - Region 1 - RiPP-like

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Location: 13,872 - 24,708 nt. (total: 10,837 nt) Show pHMM detection rules used

RiPP-like: (strepbact or Antimicrobial14 or Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or Lactococcin or Antimicrobial17 or Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or TIGR03975 or DUF692 or TIGR01193)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

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Gene details

Select a gene to view the details available for it

MIBiG comparison

KnownClusterBlast

Pfam domains

TIGRFAM domains

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001565.1	0.08	NRP	cyclosporin C	Beauveria felina
BGC0000306.1	0.07	NRP	arylomycin	Streptomyces filamentosus NRRL 11379
BGC0001190.1	0.06	Polyketide	fusaric acid	Fusarium verticillioides 7600
BGC0000260.1	0.05	Polyketide	prodigiosin	Hahella chejuensis KCTC 2396
BGC0000395.1	0.05	NRP	nocardicin A	Nocardia uniformis subsp. tsuyamanensis
BGC0000721.1	0.05	Saccharide	tobramycin	Streptoalloteichus tenebrarius
BGC0000326.1	0.04	NRP	isocomplestatin	Streptomyces lavendulae
BGC0000299.1	0.04	NRP	alterochromide A, bromoalterochromide A, dibromoalterochromide A, alterochromide B, bromoalterochromide B, dibromoalterochromide B, alterochromide A', bromoalterochromide A', dibromoalterochromide A', alterochromide B', bromoalterochromide B', dibromoalterochromide B', alterochromide A'', bromoalterochromide A'', alterochromide B'', bromoalterochromide B''	Pseudoalteromonas piscicida JCM 20779
BGC0001230.1	0.04	NRP, Polyketide	salinamide A, salinamide B, salinamide C, salinamide D, salinamide E, salinamide F, desmethylsalinamide C, desmethylsalinamide E	Streptomyces sp. CNB091
BGC0001766.1	0.04	NRP	salinamide A	Streptomyces sp. CNB091

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001565.1	0.31	NRP	cyclosporin C	Beauveria felina
BGC0000306.1	0.28	NRP	arylomycin	Streptomyces filamentosus NRRL 11379
BGC0001190.1	0.24	Polyketide	fusaric acid	Fusarium verticillioides 7600
BGC0000260.1	0.24	Polyketide	prodigiosin	Hahella chejuensis KCTC 2396
BGC0000395.1	0.22	NRP	nocardicin A	Nocardia uniformis subsp. tsuyamanensis
BGC0000721.1	0.22	Saccharide	tobramycin	Streptoalloteichus tenebrarius
BGC0000326.1	0.21	NRP	isocomplestatin	Streptomyces lavendulae
BGC0000299.1	0.20	NRP	alterochromide A, bromoalterochromide A, dibromoalterochromide A, alterochromide B, bromoalterochromide B, dibromoalterochromide B, alterochromide A', bromoalterochromide A', dibromoalterochromide A', alterochromide B', bromoalterochromide B', dibromoalterochromide B', alterochromide A'', bromoalterochromide A'', alterochromide B'', bromoalterochromide B''	Pseudoalteromonas piscicida JCM 20779
BGC0001230.1	0.20	NRP, Polyketide	salinamide A, salinamide B, salinamide C, salinamide D, salinamide E, salinamide F, desmethylsalinamide C, desmethylsalinamide E	Streptomyces sp. CNB091
BGC0001766.1	0.20	NRP	salinamide A	Streptomyces sp. CNB091

Similar known gene clusters

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Detailed TIGRFAM domain annotation

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c00003_NZ_JHYF.. - Region 1 - resorcinol

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Location: 83,950 - 125,062 nt. (total: 41,113 nt) Show pHMM detection rules used

resorcinol: DarB

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MIBiG comparison

KnownClusterBlast

Pfam domains

TIGRFAM domains

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000907.1	0.25	Other	lincomycin	Streptomyces lincolnensis
BGC0000880.1	0.23	Other (Nucleoside)	tunicamycin B1	Streptomyces chartreusis NRRL 3882
BGC0001526.1	0.23	Other	bartolosides E, bartolosides F, bartolosides G, bartolosides H, bartolosides I, bartolosides J, bartolosides K	Synechocystis salina LEGE 06099
BGC0001591.1	0.23	Other	fatty acid enol ester	uncultured bacterium CSLC2
BGC0001688.1	0.23	Other	N-tetradecanoyl tyrosine	uncultured bacterium CSLC2
BGC0000938.1	0.22	Other (Aminocoumarin)	fosfomycin	Streptomyces fradiae
BGC0001525.1	0.21	Other	bartoloside 2, bartoloside 3, bartoloside 4	Synechocystis salina LEGE 06155
BGC0001369.1	0.20	Polyketide	metatricycloene	uncultured bacterium
BGC0001730.1	0.20	Polyketide	paramagnetoquinone 1, paramagnetoquinone 2	Actinoallomurus sp.
BGC0000692.1	0.20	Saccharide	apramycin	Streptoalloteichus hindustanus

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000907.1	0.59	Other	lincomycin	Streptomyces lincolnensis
BGC0000880.1	0.57	Other (Nucleoside)	tunicamycin B1	Streptomyces chartreusis NRRL 3882
BGC0001526.1	0.56	Other	bartolosides E, bartolosides F, bartolosides G, bartolosides H, bartolosides I, bartolosides J, bartolosides K	Synechocystis salina LEGE 06099
BGC0001591.1	0.56	Other	fatty acid enol ester	uncultured bacterium CSLC2
BGC0001688.1	0.56	Other	N-tetradecanoyl tyrosine	uncultured bacterium CSLC2
BGC0000938.1	0.55	Other (Aminocoumarin)	fosfomycin	Streptomyces fradiae
BGC0001525.1	0.54	Other	bartoloside 2, bartoloside 3, bartoloside 4	Synechocystis salina LEGE 06155
BGC0001369.1	0.53	Polyketide	metatricycloene	uncultured bacterium
BGC0001730.1	0.52	Polyketide	paramagnetoquinone 1, paramagnetoquinone 2	Actinoallomurus sp.
BGC0000692.1	0.52	Saccharide	apramycin	Streptoalloteichus hindustanus

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c00014_NZ_JHYF.. - Region 1 - NRPS

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Location: 17,740 - 88,588 nt. (total: 70,849 nt) Show pHMM detection rules used

NRPS: cds(Condensation and (AMP-binding or A-OX))

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NRPS/PKS domains

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NRPS/PKS modules

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Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001615.1	0.34	NRP	hexose-palythine-serine, hexose-shinorine	Heteroscytonema crispum UCFS10
BGC0001844.1	0.34	NRP	holrhizin	Paraburkholderia rhizoxinica HKI 454
BGC0000426.1	0.34	NRP	sevadicin	Paenibacillus larvae
BGC0000389.1	0.33	NRP	massetolide A	Pseudomonas fluorescens SS101
BGC0001131.1	0.32	NRP	ambactin	Xenorhabdus miraniensis
BGC0001833.1	0.32	NRP	icosalide A, icosalide B	Burkholderia gladioli
BGC0000417.1	0.32	NRP	rhodochelin	Rhodococcus jostii RHA1
BGC0001758.1	0.31	NRP	rhizomide A, rhizomide B, rhizomide C	Paraburkholderia rhizoxinica HKI 454
BGC0001185.1	0.31	NRP	bacillibactin	Bacillus velezensis FZB42
BGC0000396.1	0.30	NRP	nodularin	Nostoc sp. 73.1

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001615.1	0.67	NRP	hexose-palythine-serine, hexose-shinorine	Heteroscytonema crispum UCFS10
BGC0001844.1	0.67	NRP	holrhizin	Paraburkholderia rhizoxinica HKI 454
BGC0000426.1	0.67	NRP	sevadicin	Paenibacillus larvae
BGC0000389.1	0.66	NRP	massetolide A	Pseudomonas fluorescens SS101
BGC0001131.1	0.66	NRP	ambactin	Xenorhabdus miraniensis
BGC0001833.1	0.65	NRP	icosalide A, icosalide B	Burkholderia gladioli
BGC0000417.1	0.65	NRP	rhodochelin	Rhodococcus jostii RHA1
BGC0001758.1	0.64	NRP	rhizomide A, rhizomide B, rhizomide C	Paraburkholderia rhizoxinica HKI 454
BGC0001185.1	0.64	NRP	bacillibactin	Bacillus velezensis FZB42
BGC0000396.1	0.64	NRP	nodularin	Nostoc sp. 73.1

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NRPS/PKS products

NRPS/PKS monomers

Predicted core structure(s)

For candidate cluster 1, location 17739 - 88588:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (D-asn) + (ser - X - cys - asp - X - gly)

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Link to NORINE database query form

NRPS/PKS monomer predictions

ctg14_39

Search NORINE for peptide: strict or relaxed

AMP-binding (485..889): ser

NRPSPredictor2: ser

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic
Large clusters prediction:: ser, thr, dhpg, hpg
Small clusters prediction:: ser
Single AA prediction:: ser

Stachelhaus prediction details:

Stachelhaus sequence:: DVWHFSLVDK
Nearest Stachelhaus code:: ser
Stachelhaus code match:: 100% (strong)

AMP-binding (1533..1930): X

NRPSPredictor2: hydrophobic-aliphatic

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic
Large clusters prediction:: N/A
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: DVinIGiIyK
Nearest Stachelhaus code:: orn
Stachelhaus code match:: 60% (weak)

AMP-binding (2570..2969): cys

NRPSPredictor2: cys

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic
Large clusters prediction:: cys
Small clusters prediction:: cys
Single AA prediction:: cys

Stachelhaus prediction details:

Stachelhaus sequence:: DLYNLSgIWK
Nearest Stachelhaus code:: cys
Stachelhaus code match:: 90% (moderate)

AMP-binding (3612..4012): asp

NRPSPredictor2: asp

SVM prediction details:

Predicted physicochemical class:: hydrophilic
Large clusters prediction:: asp, asn, glu, gln, aad
Small clusters prediction:: asp, asn
Single AA prediction:: asp

Stachelhaus prediction details:

Stachelhaus sequence:: DLTKiGHIGK
Nearest Stachelhaus code:: asp
Stachelhaus code match:: 90% (moderate)

AMP-binding (4654..5048): X

NRPSPredictor2: orn, lys, arg

SVM prediction details:

Predicted physicochemical class:: hydrophilic
Large clusters prediction:: orn, lys, arg
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: DVeqIGntDK
Nearest Stachelhaus code:: orn
Stachelhaus code match:: 60% (weak)

AMP-binding (5692..6091): gly

NRPSPredictor2: gly

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic
Large clusters prediction:: gly, ala, val, leu, ile, abu, iva
Small clusters prediction:: N/A
Single AA prediction:: gly

Stachelhaus prediction details:

Stachelhaus sequence:: DILQmGMIWK
Nearest Stachelhaus code:: gly
Stachelhaus code match:: 90% (moderate)

ctg14_44

Search NORINE for peptide: strict or relaxed

CAL_domain (38..483): pk

minowa: fatty_acid

Prediction, score:

fatty_acid: 202.2
NH2: 26.8
shikimic_acid: 0.0
Acetyl-CoA: 0.0
AHBA: 0.0

AMP-binding (1120..1514): asn

NRPSPredictor2: asn

SVM prediction details:

Predicted physicochemical class:: hydrophilic
Large clusters prediction:: asp, asn, glu, gln, aad
Small clusters prediction:: asp, asn
Single AA prediction:: asn

Stachelhaus prediction details:

Stachelhaus sequence:: DLTKIGEVGK
Nearest Stachelhaus code:: asn
Stachelhaus code match:: 100% (strong)